SYMBOL-HF

Publikationen

2018

Brockmann, S.J., Freischmidt, A., Oeckl, P., Müller, K., Ponna, S.K., Helferich, A.M., Paone, C., Reinders, J., Kojer, K., Orth, M., Jokela, M., Auranen, M., Udd, B., Hermann, A., Danzer, K.M., Lichtner, P., Walther, P., Ludolph, A.C., Andersen, P.M., Otto, M., Kursula, P., Just, S., Weishaupt, J.H., 2018. CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum. Mol. Genet. 27, 706–715. doi.org/10.1093/hmg/ddx436

Keßler, M., Kieltsch, A., Kayvanpour, E., Katus, H.A., Schoser, B., Schessl, J., Just, S., Rottbauer, W., 2018. A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations. Neuromuscul. Disord. doi.org/10.1016/j.nmd.2018.03.001

Kramer, F., Just, S., Zeller, T., 2018. New perspectives: systems medicine in cardiovascular disease. BMC Syst Biol 12, 57. doi.org/10.1186/s12918-018-0579-5

Kraus, J.M., Lausser, L., Kuhn, P., Jobst, F., Bock, M., Halanke, C., Hummel, M., Heuschmann, P., Kestler, H.A., 2018. Big data and precision medicine: challenges and strategies with healthcare data. Int J Data Sci Anal 1–9. doi.org/10.1007/s41060-018-0095-0

Neupane, B., Zhou, Q., Gawaz, M., Gramlich, M., 2018. Personalized medicine in inflammatory cardiomyopathy. Pers. Med. 15, 127–136. doi.org/10.2217/pme-2017-0074

Paone, C., Rudeck, S., Etard, C., Strähle, U., Rottbauer, W., Just, S., 2018. Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response. Biochem. Biophys. Res. Commun. 496, 339–345. doi.org/10.1016/j.bbrc.2018.01.060

Pott, A., Bock, S., Berger, I.M., Frese, K., Dahme, T., Kessler, M., Rinné, S., Decher, N., Just, S., Rottbauer, W., 2018. Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish. J. Mol. Cell. Cardiol. doi.org/10.1016/j.yjmcc.2018.05.005

Schwab, J.D., Kestler, H.A., 2018. Automatic Screening for Perturbations in Boolean Networks. Front Physiol 9, 431. doi.org/10.3389/fphys.2018.00431

Siegle, L., Schwab, J.D., Kühlwein, S.D., Lausser, L., Tümpel, S., Pfister, A.S., Kühl, M., Kestler, H.A., 2018. A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells. PLoS ONE 13, e0195126. doi.org/10.1371/journal.pone.0195126

2017

Lausser, L., Szekely, R., Schirra, L.-R., Kestler, H.A., 2017. The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes. Neural Process Lett 1–18. doi.org/10.1007/s11063-017-9706-3

Meyer, P., Maity, P., Burkovski, A., Schwab, J., Müssel, C., Singh, K., Ferreira, F.F., Krug, L., Maier, H.J., Wlaschek, M., Wirth, T., Kestler, H.A., Scharffetter-Kochanek, K., 2017. A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence. PLoS Comput. Biol. 13, e1005741. doi.org/10.1371/journal.pcbi.1005741

Rangrez, A.Y., Hoppe, P., Kuhn, C., Zille, E., Frank, J., Frey, N., Frank, D., 2017a. MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2. PLoS ONE 12, e0183901. doi.org/10.1371/journal.pone.0183901

Rangrez, A.Y., Pott, J., Kluge, A., Frauen, R., Stiebeling, K., Hoppe, P., Sossalla, S., Frey, N., Frank, D., 2017b. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochim. Biophys. Acta 1864, 634–644. doi.org/10.1016/j.bbamcr.2017.01.004

Schwab, J., Burkovski, A., Siegle, L., Müssel, C., Kestler, H.A., 2017. ViSiBooL-visualization and simulation of Boolean networks with temporal constraints. Bioinformatics 33, 601–604. doi.org/10.1093/bioinformatics/btw661

Zhou, Q., Schötterl, S., Backes, D., Brunner, E., Hahn, J.K., Ionesi, E., Aidery, P., Sticht, C., Labeit, S., Kandolf, R., Gawaz, M., Gramlich, M., 2017. Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy. Int. J. Cardiol. 230, 634–641. doi.org/10.1016/j.ijcard.2016.12.171

 

2016

Bühler, A., Kustermann, M., Bummer, T., Rottbauer, W., Sandri, M., Just, S., 2016. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci 17. doi.org/10.3390/ijms17020187

Hirth, S., Bühler, A., Bührdel, J.B., Rudeck, S., Dahme, T., Rottbauer, W., Just, S., 2016. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE 11, e0150323. doi.org/10.1371/journal.pone.0150323

Hoffmann, S., Clauss, S., Berger, I.M., Weiß, B., Montalbano, A., Röth, R., Bucher, M., Klier, I., Wakili, R., Seitz, H., Schulze-Bahr, E., Katus, H.A., Flachsbart, F., Nebel, A., Guenther, S.P., Bagaev, E., Rottbauer, W., Kääb, S., Just, S., Rappold, G.A., 2016. Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. Basic Res. Cardiol. 111, 36. doi.org/10.1007/s00395-016-0557-2

Just, S., Hirth, S., Berger, I.M., Fishman, M.C., Rottbauer, W., 2016a. The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation. Biochem. Biophys. Res. Commun. 477, 581–588. doi.org/10.1016/j.bbrc.2016.06.088

Just, S., Raphel, L., Berger, I.M., Bühler, A., Keßler, M., Rottbauer, W., 2016b. Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. PLoS ONE 11, e0167306. doi.org/10.1371/journal.pone.0167306

Lausser, L., Schmid, F., Schirra, L.-R., Wilhelm, A.F.X., Kestler, H.A., 2016. Rank-based classifiers for extremely high-dimensional gene expression data. Adv Data Anal Classif 1–20. doi.org/10.1007/s11634-016-0277-3


2015

Keßler, M., Rottbauer, W., Just, S., 2015. Recent progress in the use of zebrafish for novel cardiac drug discovery. Expert Opin Drug Discov 10, 1231–1241. http://doi.org/10.1517/17460441.2015.1078788