CAPSyS

Publications

2019

Regier, Y., Komma, K., Weigel, M., Kraiczy, P., Laisi, A., Pulliainen, A. T., Hain, T.Kempf, V. A. J., 2019. Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany. Parasit Vectors, 12(1), 11. doi.org/10.1186/s13071-018-3240-7

Schulte, L. N., Bertrams, W., Stielow, C.Schmeck, B., 2019. ncRNAs in Inflammatory and Infectious Diseases. Methods Mol Biol, 1912, 3-32. doi.org/10.1007/978-1-4939-8982-9_1

2018

Berger, S., Goekeri, C., Gupta, S. K., Vera, J., Dietert, K., Behrendt, U., Lienau, J., Wienhold, S.-M., Gruber, A. D., Suttorp, N., Witzenrath, M.Nouailles, G., 2018. Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia. Crit Care, 22(1), 287. doi.org/10.1186/s13054-018-2224-5

Dietert, K., Nouailles, G., Gutbier, B., Reppe, K., Berger, S., Jiang, X., Schauer, A. E., Hocke, A. C., Herold, S., Slevogt, H., Witzenrath, M., Suttorp, N.Gruber, A. D., 2018. Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia. Am. J. Respir. Cell Mol. Biol., 58(4), 440-448. doi.org/10.1165/rcmb.2017-0337MA

Gutbier, B., Neuhauß, A.-K., Reppe, K., Ehrler, C., Santel, A., Kaufmann, J., Scholz, M., Weissmann, N., Morawietz, L., Mitchell, T. J., Aliberti, S., Hippenstiel, S., Suttorp, N., Witzenrath, M., Capnetz‡, P. S. G., 2018. Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia. Am. J. Respir. Crit. Care Med., 198(2), 220-231. doi.org/10.1164/rccm.201708-1733OC

Gutbier, B., Schönrock, S. M., Ehrler, C., Haberberger, R., Dietert, K., Gruber, A. D., Kummer, W., Michalick, L., Kuebler, W. M., Hocke, A. C., Szymanski, K., Letsiou, E., Lüth, A., Schumacher, F., Kleuser, B., Mitchell, T. J., Bertrams, W., Schmeck, B., Treue, D., Klauschen, F., Bauer, T. T., Tönnies, M., Weissmann, N., Hippenstiel, S., Suttorp, N., Witzenrath, M.Group, C. S., 2018. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Crit. Care Med. doi.org/10.1097/CCM.0000000000002916

Hopp, L., Loeffler-Wirth, H., Nersisyan, L., Arakelyan, A.Binder, H., 2018. Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome. Front. Immunol., 9, 1620. doi.org/10.3389/fimmu.2018.01620

Kaplonek, P., Khan, N., Reppe, K., Schumann, B., Emmadi, M., Lisboa, M. P., Xu, F.-F., Calow, A. D. J., Parameswarappa, S. G., Witzenrath, M., Pereira, C. L.Seeberger, P. H., 2018. Improving vaccines against Streptococcus pneumoniae using synthetic glycans. Proc. Natl. Acad. Sci. U.S.A., 115(52), 13353-13358. doi.org/10.1073/pnas.1811862115

Marin-Sanguino, A., Vera, J.Alves, R., 2018. Editorial: Foundations of Theoretical Approaches in Systems Biology. Front Genet, 9, 290. doi.org/10.3389/fgene.2018.00290

Regier, Y., Komma, K., Weigel, M., Pulliainen, A. T., Goettig, S., Hein, T.Kempf, V. A. J., 2018. Microbiome Analysis Reveals the Presence of Bartonella spp. and Acinetobacter spp. in Deer Keds (Lipoptena cervi). Front Microbiol, 9, 3100. doi.org/10.3389/fmicb.2018.03100

Ruiz-Moreno, J. S., Hamann, L., Jin, L., Sander, L. E., Puzianowska-Kuznicka, M., Cambier, J., Witzenrath, M., Schumann, R. R., Suttorp, N.Opitz, B., 2018. The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infect. Immun., 86(3). doi.org/10.1128/IAI.00849-17

Ruiz-Moreno, J. S., Hamann, L., Shah, J. A., Verbon, A., Mockenhaupt, F. P., Puzianowska-Kuznicka, M., Naujoks, J., Sander, L. E., Witzenrath, M., Cambier, J. C., Suttorp, N., Schumann, R. R., Jin, L., Hawn, T. R., Opitz, B.Group, C. S., 2018. The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. PLoS Pathog., 14(1), e1006829. doi.org/10.1371/journal.ppat.1006829

Santos, G., Lai, X., Eberhardt, M.Vera, J., 2018. Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling. Front Cell Infect Microbiol, 8. doi.org/10.3389/fcimb.2018.00159

Scheller, N., Herold, S., Kellner, R., Bertrams, W., Jung, A. L., Janga, H., Greulich, T., Schulte, L. N., Vogelmeier, C. F., Lohmeyer, J.Schmeck, B., 2018. Pro-viral miRNAs detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS. J Infect Dis. doi.org/10.1093/infdis/jiy554

Schumann, B., Reppe, K., Kaplonek, P., Wahlbrink, A., Anish, C., Witzenrath, M., Pereira, C. L.Seeberger, P. H., 2018. Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1. ACS Cent Sci, 4(3), 357-361. doi.org/10.1021/acscentsci.7b00504

Vera, J.Santos, G., 2018. Can Gamification Contribute to Computer Modeling-Driven Biomedical Research? Front Physiol, 9, 908. doi.org/10.3389/fphys.2018.00908

Wienhold, S.-M., Macrì, M., Nouailles, G., Dietert, K., Gurtner, C., Gruber, A. D., Heimesaat, M. M., Lienau, J., Schumacher, F., Kleuser, B., Opitz, B., Suttorp, N., Witzenrath, M.Müller-Redetzky, H. C., 2018. Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice. Crit Care, 22(1), 282. doi.org/10.1186/s13054-018-2213-8

2017

Arakelyan, A., Nersisyan, L., Poghosyan, D., Khondkaryan, L., Hakobyan, A., Löffler-Wirth, H., Melanitou, E., Binder, H., 2017. Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles. PLoS ONE 12, e0187572. doi.org/10.1371/journal.pone.0187572

Cantone, M., Santos, G., Wentker, P., Lai, X., Vera, J., 2017. Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection. Front Physiol 8, 645. doi.org/10.3389/fphys.2017.00645

Emmadi, M., Khan, N., Lykke, L., Reppe, K., G Parameswarappa, S., Lisboa, M.P., Wienhold, S.-M., Witzenrath, M., Pereira, C.L., Seeberger, P.H., 2017. A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease. J. Am. Chem. Soc. 139, 14783–14791. doi.org/10.1021/jacs.7b07836

Gutbier, B., Jiang, X., Dietert, K., Ehrler, C., Lienau, J., Van Slyke, P., Kim, H., Hoang, V.C., Maynes, J.T., Dumont, D.J., Gruber, A.D., Weissmann, N., Mitchell, T.J., Suttorp, N., Witzenrath, M., 2017. Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia. Crit Care 21, 274. doi.org/10.1186/s13054-017-1851-6

Jensen, A.V., Faurholt-Jepsen, D., Egelund, G.B., Andersen, S.B., Petersen, P.T., Benfield, T., Witzenrath, M., Rohde, G., Ravn, P., German Community-Acquired Pneumonia Competence Network (CAPNETZ), German Community-Acquired Pneumonia Competence Network (CAPNETZ), 2017. Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study. Clin. Infect. Dis. 65, 2091–2098. doi.org/10.1093/cid/cix703

Jentho, E., Bodden, M., Schulz, C., Jung, A.-L., Seidel, K., Schmeck, B., Bertrams, W., 2017. microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1. PLoS ONE 12, e0176204. doi.org/10.1371/journal.pone.0176204

Jung, A.L., Herkt, C.E., Schulz, C., Bolte, K., Seidel, K., Scheller, N., Sittka-Stark, A., Bertrams, W., Schmeck, B., 2017a. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep 7, 6301. doi.org/10.1038/s41598-017-06443-1

Jung, A.L., Hoffmann, K., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2017b. Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages. J Vis Exp. doi.org/10.3791/55146

Lisboa, M.P., Khan, N., Martin, C., Xu, F.-F., Reppe, K., Geissner, A., Govindan, S., Witzenrath, M., Pereira, C.L., Seeberger, P.H., 2017. Semisynthetic glycoconjugate vaccine candidate againstStreptococcus pneumoniaeserotype 5. Proc. Natl. Acad. Sci. U.S.A. 114, 11063–11068. doi.org/10.1073/pnas.1706875114

Ruiz-Moreno, J.S., Hamann, L., Jin, L., Sander, L.E., Puzianowska-Kuznicka, M., Cambier, J., Witzenrath, M., Schumann, R.R., Suttorp, N., Opitz, B., CAPNETZ Study Group, 2017. The cGAS/STING pathway detects Streptococcus pneumoniae but appears dispensable for anti-pneumococcal defense in mice and humans. Infect. Immun. doi.org/10.1128/IAI.00849-17

Schulz, C., Lai, X., Bertrams, W., Jung, A.L., Sittka-Stark, A., Herkt, C.E., Janga, H., Zscheppang, K., Stielow, C., Schulte, L., Hippenstiel, S., Vera, J., Schmeck, B., 2017. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study. Sci Rep 7, 11988. doi.org/10.1038/s41598-017-12154-4

Schumann, B., Hahm, H.S., Parameswarappa, S.G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L.-A., Witzenrath, M., Anish, C., Pereira, C.L., Seeberger, P.H., 2017. A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine. Sci Transl Med 9. doi.org/10.1126/scitranslmed.aaf5347

Seeberger, P.H., Pereira, C.L., Khan, N., Xiao, G., Diago-Navarro, E., Reppe, K., Opitz, B., Fries, B.C., Witzenrath, M., 2017. A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae. Angew. Chem. Int. Ed. Engl. 56, 13973–13978. doi.org/10.1002/anie.201700964

Wentker, P., Eberhardt, M., Dreyer, F.S., Bertrams, W., Cantone, M., Griss, K., Schmeck, B., Vera, J., 2017. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J. Immunol. 198, 2191–2201. https://doi.org/10.4049/jimmunol.1502513

2016

Arakelyan, A., Nersisyan, L., Petrek, M., Löffler-Wirth, H., Binder, H., 2016. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet 7, 79. doi.org/10.3389/fgene.2016.00079

Du Bois, I., Marsico, A., Bertrams, W., Schweiger, M.R., Caffrey, B.E., Sittka-Stark, A., Eberhardt, M., Vera, J., Vingron, M., Schmeck, B.T., 2016. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J. Infect. Dis. 214, 454–463. doi.org/10.1093/infdis/jiw171

Eberhardt, M., Lai, X., Tomar, N., Gupta, S., Schmeck, B., Steinkasserer, A., Schuler, G., Vera, J., 2016. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol. Biol. 1386, 135–179. doi.org/10.1007/978-1-4939-3283-2_9

Garn, H., Bahn, S., Baune, B.T., Binder, E.B., Bisgaard, H., Chatila, T.A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Müller-Ladner, U., Neurath, M.F., Preissner, K.T., Reinhardt, C., Rook, G., Russell, S., Schmeck, B., Stappenbeck, T., Steinhoff, U., van Os, J., Weiss, S., Zemlin, M., Renz, H., 2016. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J. Allergy Clin. Immunol. 138, 47–56. doi.org/10.1016/j.jaci.2016.02.046

Griss, K., Bertrams, W., Sittka-Stark, A., Seidel, K., Stielow, C., Hippenstiel, S., Suttorp, N., Eberhardt, M., Wilhelm, J., Vera, J., Schmeck, B., 2016. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J. Infect. Dis. 214, 288–299. doi.org/10.1093/infdis/jiw109

Jung, A.L., Stoiber, C., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2016. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 12, e1005592. doi.org/10.1371/journal.ppat.1005592

Kirschner, F., Reppe, K., Andresen, N., Witzenrath, M., Ebstein, F., Kloetzel, P.-M., 2016. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS ONE 11, e0153847. doi.org/10.1371/journal.pone.0153847

Lai, X., Wolkenhauer, O., Vera, J., 2016. Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res. 44, 6019–6035. doi.org/10.1093/nar/gkw550

Parameswarappa, S.G., Reppe, K., Geissner, A., Ménová, P., Govindan, S., Calow, A.D.J., Wahlbrink, A., Weishaupt, M.W., Monnanda, B.P., Bell, R.L., Pirofski, L.-A., Suttorp, N., Sander, L.E., Witzenrath, M., Pereira, C.L., Anish, C., Seeberger, P.H., 2016. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection. Cell Chem Biol 23, 1407–1416. doi.org/10.1016/j.chembiol.2016.09.016

Santos, G., Nikolov, S., Lai, X., Eberhardt, M., Dreyer, F.S., Paul, S., Schuler, G., Vera, J., 2016. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis. Sci Rep 6, 24967. doi.org/10.1038/srep24967

Schirm, S., Ahnert, P., Wienhold, S., Mueller-Redetzky, H., Nouailles-Kursar, G., Loeffler, M., Witzenrath, M., Scholz, M., 2016. A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice. PLoS ONE 11, e0156047. doi.org/10.1371/journal.pone.0156047

Schmeck, B., Bertrams, W., Lai, X., Vera, J., 2016. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol. Biol. 1386, 119–133. http://doi.org/10.1007/978-1-4939-3283-2_8

2015

Lienau, J., Müller-Redetzky, H., Suttorp, N., Witzenrath, M., 2015. [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia]. Pneumologie. doi.org/10.1055/s-0035-1563788

Müller-Redetzky, H., Lienau, J., Suttorp, N., Witzenrath, M., 2015. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev 24, 516–524. doi.org/10.1183/16000617.0034-2015

Reppe, K., Radünzel, P., Dietert, K., Tschernig, T., Wolff, T., Hammerschmidt, S., Gruber, A.D., Suttorp, N., Witzenrath, M., 2015. Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. Infect. Immun. 83, 4617–4629. http://doi.org/10.1128/IAI.00948-15

2014

Witzenrath, M., 2014. Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff! Am. J. Respir. Crit. Care Med. 189, 1452–1455. doi.org/10.1164/rccm.201405-0827ED