CKDNapp

Ben Guebila, M., T. Wang, C. M. Lopes-Ramos, V. Fanfani, D. Weighill, R. Burkholz, D. Schlauch, J. N. Paulson, M. Altenbuchinger, K. H. Shutta, A. R. Sonawane, J. Lim, G. Calderer, D. G. P. van IJzendoorn, D. Morgan, A. Marin, C.-Y. Chen, Q. Song, E. Saha, D. L. DeMeo, M. Padi, J. Platig, M. L. Kuijjer, K. Glass, and J. Quackenbush (2023). "The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks." Genome Biol 24(1): 1–23. CKDNapp  doi.org/10.1186/s13059-023-02877-1.

Buck, L., T. Schmidt, M. Feist, P. Schwarzfischer, D. Kube, P. J. Oefner, H. U. Zacharias, M. Altenbuchinger, K. Dettmer, W. Gronwald, and R. Spang (2023). "Anomaly detection in mixed high-dimensional molecular data." Bioinformatics 39(8). CKDNapp  doi.org/10.1093/bioinformatics/btad501.

Cejka, V., S. Störk, J. Nadal, M. Schmid, C. Sommerer, T. Sitter, H. Meiselbach, M. Busch, M. P. Schneider, T. Saritas, U. T. Schultheiss, F. Kotsis, C. Wanner, K.-U. Eckardt, V. Krane, K.-U. Eckardt, H. Meiselbach, M. P. Schneider, M. Schiffer, H.-U. Prokosch, B. Bärthlein, A. Beck, A. Reis, A. B. Ekici, S. Becker, D. Becker-Grosspitsch, U. Alberth-Schmidt, B. Hausknecht, A. Weigel, G. Walz, A. Köttgen, U. T. Schultheiß, F. Kotsis, S. Meder, E. Mitsch, U. Reinhard, J. Floege, T. Saritas, E. Schaeffner, S. Baid-Agrawal, K. Theisen, H. Haller, M. Zeier, C. Sommerer, J. Theilinger, G. Wolf, M. Busch, R. Paul, T. Sitter, C. Wanner, V. Krane, A. Börner-Klein, B. Bauer, F. Kronenberg, J. Raschenberger, B. Kollerits, L. Forer, S. Schönherr, H. Weissensteiner, P. Oefner, W. Gronwald, M. Schmid, and J. Nadal (2023). "Differential prognostic utility of adiposity measures in chronic kidney disease." Journal of Renal Nutrition 0(0). CKDNapp  doi.org/10.1053/j.jrn.2023.04.006.

Funer, F., W. Liedtke, S. Tinnemeyer, A. D. Klausen, D. Schneider, H. U. Zacharias, M. Langanke, and S. Salloch (2023). "Responsibility and decision-making authority in using clinical decision support systems: an empirical-ethical exploration of German prospective professionals’ preferences and concerns." J Med Ethics: 2022–108814. CKDNapp  doi.org/10.1136/jme-2022-108814.

Kosch, R., K. Limm, A. M. Staiger, N. S. Kurz, N. Seifert, B. Oláh, S. Solbrig, M. Ziepert, E. Chteinberg, R. S. Spang, Reiner, H. U. Zacharias, G. Ott, P. J. Oefner, and M. Altenbuchinger (2023). "PriOmics: integration of high-throughput proteomic data with complementary omics layers using mixed graphical modeling with group priors." bioRxiv: 2023.2011. 2010.566517. CKDNapp  doi.org/10.1101/2023.11.10.566517.

Kotsis, F., H. Bächle, M. Altenbuchinger, J. Dönitz, Y. A. Njipouombe Nsangou, H. Meiselbach, R. Kosch, S. Salloch, T. Bratan, H. U. Zacharias, and U. T. Schultheiss (2023). "Expectation of clinical decision support systems: a survey study among nephrologist end-users." BMC Medical Informatics and Decision Making 23(1): 239. CKDNapp  doi.org/10.1186/s12911-023-02317-x.

Reimer, K. C., J. Nadal, H. Meiselbach, M. Schmid, U. T. Schultheiss, F. Kotsis, H. Stockmann, N. Friedrich, M. Nauck, V. Krane, K. U. Eckardt, M. P. Schneider, R. Kramann, J. Floege, T. Saritas, and G. S. Investigators (2023). "Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort." Bone Research 11(1). CKDNapp  doi.org/10.1038/s41413-023-00291-8.

Ruhe, J., J. Nadal, B. Bärthlein, H. Meiselbach, U. T. Schultheiss, F. Kotsis, H. Stockmann, V. Krane, C. Sommerer, I. Löffler, T. Saritas, J. T. Kielstein, T. Sitter, M. P. Schneider, M. Schmid, C. Wanner, K.-U. Eckardt, G. Wolf, and M. Busch (2023). "Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease—prospective data from the German Chronic Kidney Disease cohort." Clinical Kidney Journal 16(11): 2032-2040. CKDNapp  doi.org/10.1093/ckj/sfad194.

Schlosser, P., N. Scherer, F. Grundner-Culemann, S. Monteiro-Martins, S. Haug, I. Steinbrenner, B. Uluvar, M. Wuttke, Y. Cheng, A. B. Ekici, G. Gyimesi, E. D. Karoly, F. Kotsis, J. Mielke, M. F. Gomez, B. Yu, M. E. Grams, J. Coresh, E. Boerwinkle, M. Köttgen, F. Kronenberg, H. Meiselbach, R. P. Mohney, S. Akilesh, M. Schmidts, M. A. Hediger, U. T. Schultheiss, K.-U. Eckardt, P. J. Oefner, P. Sekula, Y. Li, and A. Köttgen (2023). "Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine." Nat Genet 55: 995–1008. CKDNapp  doi.org/10.1038/s41588-023-01409-8.

Schumann, A., U. T. Schultheiss, C. R. Ferreira, and N. Blau (2023). "Clinical and biochemical footprints of inherited metabolic diseases. XIV. Metabolic kidney diseases." Molecular Genetics and Metabolism 140(3): 107683. CKDNapp  doi.org/10.1016/j.ymgme.2023.107683.

Sommerer, C., S. Müller-Krebs, J. Nadal, U. T. Schultheiss, N. Friedrich, M. Nauck, M. Schmid, C. Nußhag, J. Reiser, K.-U. Eckardt, M. Zeier, and S. S. Hayek (2023). "Prospective cohort study of soluble urokinase plasminogen activation receptor and cardiovascular events in patients with CKD." Kidney International Reports 8(11): 2265-2275. CKDNapp  doi.org/10.1016/j.ekir.2023.08.038.

Sood, M., U. Suenkel, A.-K. von Thaler, H. U. Zacharias, K. Brockmann, G. W. Eschweiler, W. Maetzler, D. Berg, H. Fröhlich, and S. Heinzel (2023). "Bayesian network modeling of risk and prodromal markers of Parkinson’s disease." PLoS One 18(2): e0280609. CKDNapp  doi.org/10.1371/journal.pone.0280609.

von Samson-Himmelstjerna, F. A., B. Kolbrink, N. Kakavand, H. U. Zacharias, and K. Schulte (2023). "The German Transplantation Registry Reveals Deficiencies in the Listing Process for Kidney Transplantation." Kidney International Reports. CKDNapp  doi.org/10.1016/j.ekir.2023.09.031.

Altenbuchinger, M., H. Berndt, R. Kosch, I. Lang, J. Dönitz, P. J. Oefner, W. Gronwald, H. U. Zacharias and I. G. Study (2022). "Bucket Fuser: Statistical Signal Extraction for 1D 1H NMR Metabolomic Data." Metabolites 12(9): 812. CKDNapp doi.org/10.3390/metabo12090812.

Bächle, H., P. Sekula, P. Schlosser, I. Steinbrenner, Y. Cheng, F. Kotsis, H. Meiselbach, H. Stockmann, S. Schönherr, G. investigators, K.-U. Eckardt, O. Devuyst, J. Scherberich, A. Köttgen and U. T. Schultheiss (2022). "Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study." Nephrology Dialysis Transplantation. CKDNapp doi.org/10.1093/ndt/gfac187.

Ben Guebila, M., D. Weighill, C. M. Lopes-Ramos, R. Burkholz, R. T. Pop, K. Palepu, M. Shapoval, M. Fagny, D. Schlauch, K. Glass, M. Altenbuchinger, M. L. Kuijjer, J. Platig and J. Quackenbush (2022). "An online notebook resource for reproducible inference, analysis and publication of gene regulatory networks." Nature Methods 19(5): 511-513. CKDNapp doi.org/10.1038/s41592-022-01479-2.

Cheng, Y., Y. Li, N. Scherer, F. Grundner-Culemann, T. Lehtimäki, B. H. Mishra, O. T. Raitakari, M. Nauck, K.-U. Eckardt, P. Sekula, U. T. Schultheiss and G. i. on behalf of the (2022). "Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study." PLOS Genetics 18(4): e1010139. CKDNapp doi.org/10.1371/journal.pgen.1010139.

Kheirkhah, A., C. Lamina, B. Kollerits, J. F. Schachtl-Riess, U. T. Schultheiss, L. Forer, P. Sekula, F. Kotsis, K.-U. Eckardt and F. Kronenberg (2022). "PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function." CJASN 17(6): 809–818. CKDNapp doi.org/10.2215/CJN.01230122.

Li, Y., Y. Cheng, F. Consolato, G. Schiano, M. R. Chong, M. Pietzner, N. Q. H. Nguyen, N. Scherer, M. L. Biggs, M. E. Kleber, S. Haug, B. Göçmen, M. Pigeyre, P. Sekula, I. Steinbrenner, P. Schlosser, C. B. Joseph, J. A. Brody, M. E. Grams, C. Hayward, U. T. Schultheiss, B. K. Krämer, F. Kronenberg, A. Peters, J. Seissler, D. Steubl, C. Then, M. Wuttke, W. März, K.-U. Eckardt, C. Gieger, E. Boerwinkle, B. M. Psaty, J. Coresh, P. J. Oefner, G. Pare, C. Langenberg, J. E. Scherberich, B. Yu, S. Akilesh, O. Devuyst, L. Rampoldi and A. Köttgen (2022). "Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases." JCI Insight 7(10). CKDNapp doi.org/10.1172/jci.insight.157035.

Lück, N., R. Lohmayer, S. Solbrig, S. Schrod, T. Wipfler, K. H. Shutta, M. B. Guebila, A. Schäfer, T. Beißbarth, H. U. Zacharias, P. J. Oefner, J. Quackenbush and M. Altenbuchinger (2022). "SpaCeNet: Spatial Cellular Networks from omics data." bioRxiv: 2022.2009.2001.506219. CKDNapp doi.org/10.1101/2022.09.01.506219.

Mielke, J., H. Trucks-Jansen, C. Schurmann, F. Kotsis, A. Kottgen, M. P. Schneider, K. U. Eckardt, G. Investigators, D. F. Freitag, F. Eitner and M. S. Becker (2022). "Prevalence, phenotypic characteristics and prognostic role of apparent treatment resistant hypertension in the German Chronic Kidney Disease (GCKD) study." J Hum Hypertens. CKDNapp www.ncbi.nlm.nih.gov/pubmed/35534618.

Schrod, S., A. Schäfer, S. Solbrig, R. Lohmayer, W. Gronwald, P. J. Oefner, T. Beißbarth, R. Spang, H. U. Zacharias and M. Altenbuchinger (2022). "BITES: balanced individual treatment effect for survival data." Bioinformatics 38(Supplement_1): i60–i67. CKDNapp doi.org/10.1093/bioinformatics/btac221.

Schultheiss, U. T., H. Bächle, M. Altenbuchinger, H. Meiselbach, R. Kosch, S. Salloch, T. Bratan, H. U. Zacharias and F. Kotsis (2022). MO474: Expectation and Acceptance of a Clinical Decision Support Software by Nephrologist End-Users: The Ckdnapp Survey. 59th ERA Congress. Paris & Virtual, Nephrol Dial Transplant. 37.

Shutta, K. H., D. Weighill, R. Burkholz, M. B. Guebila, D. L. DeMeo, H. U. Zacharias, J. Quackenbush and M. Altenbuchinger (2022). "DRAGON: Determining Regulatory Associations using Graphical models on multi-Omic Networks." Nucleic Acids Res. CKDNapp doi.org/10.1093/nar/gkac1157.

Steinbrenner, I., P. Sekula, F. Kotsis, M. von Cube, Y. Cheng, J. Nadal, M. Schmid, M. P. Schneider, V. Krane, M. Nauck, K.-U. Eckardt, U. T. Schultheiss and t. G. investigators (2022). "Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study." Nephrology Dialysis Transplantation. CKDNapp doi.org/10.1093/ndt/gfac173.

Surendran, P., I. D. Stewart, V. P. W. Au Yeung, M. Pietzner, J. Raffler, M. A. Wörheide, C. Li, R. F. Smith, L. B. L. Wittemans, L. Bomba, C. Menni, J. Zierer, N. Rossi, P. A. Sheridan, N. A. Watkins, M. Mangino, P. G. Hysi, E. Di Angelantonio, M. Falchi, T. D. Spector, N. Soranzo, G. A. Michelotti, W. Arlt, L. A. Lotta, S. Denaxas, H. Hemingway, E. R. Gamazon, J. M. M. Howson, A. M. Wood, J. Danesh, N. J. Wareham, G. Kastenmüller, E. B. Fauman, K. Suhre, A. S. Butterworth and C. Langenberg (2022). "Rare and common genetic determinants of metabolic individuality and their effects on human health." Nat Med: 1–12. CKDNapp doi.org/10.1038/s41591-022-02046-0.

Winitzki, D., H. U. Zacharias, J. Nadal, S. Baid-Agrawal, E. Schaeffner, M. Schmid, M. Busch, M. M. Bergmann, U. Schultheiss, F. Kotsis, H. Stockmann, H. Meiselbach, G. Wolf, V. Krane, C. Sommerer, K.-U. Eckardt, M. P. Schneider, G. Schlieper, J. Floege and T. Saritas (2022). "Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort." Kidney International Reports 7(5): 1004–1015. CKDNapp doi.org/10.1016/j.ekir.2022.02.001.

Zacharias, H. U., M. Altenbuchinger, U. T. Schultheiss, J. Raffler, F. Kotsis, S. Ghasemi, I. Ali, B. Kollerits, M. Metzger, I. Steinbrenner, P. Sekula, Z. A. Massy, C. Combe, P. A. Kalra, F. Kronenberg, B. Stengel, K. U. Eckardt, A. Kottgen, M. Schmid, W. Gronwald, P. J. Oefner and G. Investigators (2022). "A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests." Am J Kidney Dis 79(2): 217-230 e211. CKDNapp www.ncbi.nlm.nih.gov/pubmed/34298143.

Zacharias, H. U., C. Kaleta, F. Cossais, E. Schaeffer, H. Berndt, L. Best, T. Dost, S. Glüsing, M. Groussin, M. Poyet, S. Heinzel, C. Bang, L. Siebert, T. Demetrowitsch, F. Leypoldt, R. Adelung, T. Bartsch, A. Bosy-Westphal, K. Schwarz and D. Berg (2022). "Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Targets." Metabolites 12(12): 1222. CKDNapp doi.org/10.3390/metabo12121222.

Kotsis, F., U. T. Schultheiss, M. Wuttke, P. Schlosser, J. Mielke, M. S. Becker, P. J. Oefner, E. D. Karoly, R. P. Mohney, K. U. Eckardt, P. Sekula, A. Kottgen and G. Investigators (2021). "Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study." J Am Soc Nephrol 32(9): 2315-2329. CKDNapp www.ncbi.nlm.nih.gov/pubmed/34140400.

Lotta, L. A., M. Pietzner, I. D. Stewart, L. B. L. Wittemans, C. Li, R. Bonelli, J. Raffler, E. K. Biggs, C. Oliver-Williams, V. P. W. Auyeung, J. a. Luan, E. Wheeler, E. Paige, P. Surendran, G. A. Michelotti, R. A. Scott, S. Burgess, V. Zuber, E. Sanderson, A. Koulman, F. Imamura, N. G. Forouhi, K.-T. Khaw, M. Bahlo, J. L. Griffin, A. M. Wood, G. Kastenmüller, J. Danesh, A. S. Butterworth, F. M. Gribble, F. Reimann, M. Bahlo, E. Fauman, N. J. Wareham, C. Langenberg and M. Consortium (2021). "A cross-platform approach identifies genetic regulators of human metabolism and health." Nat Genet 53(1): 54–64. CKDNapp doi.org/10.1038/s41588-020-00751-5.

Pammer, L. M., C. Lamina, U. T. Schultheiss, F. Kotsis, B. Kollerits, H. Stockmann, J. Lipovsek, H. Meiselbach, M. Busch, K.-U. Eckardt and F. Kronenberg (2021). "Association of the metabolic syndrome with mortality and major adverse cardiac events: A large chronic kidney disease cohort." J Intern Med 290(6): 1219–1232. CKDNapp doi.org/10.1111/joim.13355.

Pietzner, M., I. D. Stewart, J. Raffler, K.-T. Khaw, G. A. Michelotti, G. Kastenmüller, N. J. Wareham and C. Langenberg (2021). "Plasma metabolites to profile pathways in noncommunicable disease multimorbidity." Nat. Med. 27(3): 471–479. CKDNapp doi.org/10.1038/s41591-021-01266-0.

Schultheiss, U. T., R. Kosch, F. Kotsis, M. Altenbuchinger and H. U. Zacharias (2021). "Chronic Kidney Disease Cohort Studies: A Guide to Metabolome Analyses." Metabolites 11(7). CKDNapp doi.org/10.3390/metabo11070460.

Schultheiss, U. T. and P. Sekula (2021). "The Promise of Metabolomics in Decelerating CKD Progression in Children." CJASN 16(8): 1152–1154. CKDNapp doi.org/10.2215/CJN.07400521.

Schultheiss, U. T., I. Steinbrenner, M. Nauck, M. P. Schneider, F. Kotsis, S. Baid-Agrawal, E. Schaeffner, K.-U. Eckardt, A. Köttgen, P. Sekula, K.-U. Eckardt, H. Meiselbach, M. P. Schneider, M. Schiffer, H.-U. Prokosch, B. Bärthlein, A. Beck, D. Kraska, A. Reis, A. B. Ekici, S. Becker, D. Becker-Grosspitsch, U. Alberth-Schmidt, B. Hausknecht, A. Weigel, G. Walz, A. Köttgen, U. T. Schultheiß, F. Kotsis, S. Meder, G. Schlieper, E. Schaeffner, S. Baid-Agrawal, K. Theisen, H. Haller, J. Menne, M. Zeier, C. Sommerer, R. Woitke, G. Wolf, M. Busch, R. Paul, T. Sitter, C. Wanner, V. Krane, A. Börner-Klein, B. Bauer, J. Raschenberger, B. Kollerits, L. Forer, S. Schönherr, H. Weissensteiner, P. Oefner, W. Gronwald, M. Schmid and J. Nadal (2021). "Thyroid function, renal events and mortality in chronic kidney disease patients: the German Chronic Kidney Disease study." Clin Kidney J 14(3): 959-968. CKDNapp doi.org/10.1093/ckj/sfaa052.

Steinbrenner, I., U. T. Schultheiss, F. Kotsis, P. Schlosser, H. Stockmann, R. P. Mohney, M. Schmid, P. J. Oefner, K. U. Eckardt, A. Kottgen, P. Sekula and I. German Chronic Kidney Disease (2021). "Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study." Am J Kidney Dis 78(5): 669-677 e661. CKDNapp www.ncbi.nlm.nih.gov/pubmed/33839201.

Zacharias, H. U., J. Hertel, H. Johar, M. Pietzner, K. Lukaschek, S. Atasoy, S. Kunze, H. Volzke, M. Nauck, N. Friedrich, G. Kastenmuller, H. J. Grabe, C. Gieger, J. Krumsiek and K. H. Ladwig (2021). "A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression." Mol Psychiatry 26(12): 7372-7383. CKDNapp doi.org/10.1038/s41380-021-01176-0.

Bonk, S., J. Hertel, H. U. Zacharias, J. Terock, D. Janowitz, G. Homuth, M. Nauck, H. Völzke, H. Meyer zu Schwabedissen, S. Van der Auwera and H. J. Grabe (2020). "Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders." Sci Rep 10(22394): 1–9. IntegraMent & CKDNapp doi.org/10.1038/s41598-020-79388-7.

Fazzini, F., C. Lamina, J. Raschenberger, U. T. Schultheiss, F. Kotsis, S. Schönherr, H. Weissensteiner, L. Forer, I. Steinbrenner, H. Meiselbach, B. Bärthlein, C. Wanner, K.-U. Eckardt, A. Köttgen, F. Kronenberg and G. Investigators (2020). "Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease." Kidney International. CKDNapp doi.org/10.1016/j.kint.2020.02.034.

Pietzner, M., E. Wheeler, J. Carrasco-Zanini, J. Raffler, N. Kerrison, E. Oerton, V. Au Yeung, J. Luan, C. Finan, J. Casas, R. Ostroff, S. Williams, G. Kastenmüller, M. Ralser, E. Gamazon, N. Wareham, A. Hingorani and C. Langenberg (2020). "Genetic architecture of host proteins involved in SARS-CoV-2 infection." Nature Communications. CKDNapp doi.org/10.17863/CAM.59991.

Sekula, P., A. Tin, U. T. Schultheiss, S. Baid-Agrawal, R. P. Mohney, I. Steinbrenner, B. Yu, S. Luo, E. Boerwinkle, K.-U. Eckardt, J. Coresh, M. E. Grams and A. Kӧttgen (2020). "Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease." Sci Rep 10(10018): 1–11. CKDNapp doi.org/10.1038/s41598-020-66334-w.