CLIOMMICS

Publikationen

2020

Schrodt, J., Dudchenko, A., Knaup-Gregori, P. and Ganzinger, M. (2020). "Graph-Representation of Patient Data: a Systematic Literature Review." J Med Syst 44(4): 86. www.ncbi.nlm.nih.gov/pubmed/32166501.

2019

Chattopadhyay, S., Thomsen, H., Yadav, P., da Silva Filho, M. I., Weinhold, N., Nothen, M. M., Hoffman, P., Bertsch, U., Huhn, S., Morgan, G. J., Goldschmidt, H., Houlston, R., Hemminki, K. and Forsti, A. (2019). "Genome-wide interaction and pathway-based identification of key regulators in multiple myeloma." Commun Biol 2: 89. www.ncbi.nlm.nih.gov/pubmed/30854481.

Karmen, C., Gietzelt, M., Knaup-Gregori, P. and Ganzinger, M. (2019). "Methods for a similarity measure for clinical attributes based on survival data analysis." BMC Med Inform Decis Mak 19(1): 195. www.ncbi.nlm.nih.gov/pubmed/31638963.

Khoo, W. H., Ledergor, G., Weiner, A., Roden, D. L., Terry, R. L., McDonald, M. M., Chai, R. C., De Veirman, K., Owen, K. L., Opperman, K. S., Vandyke, K., Clark, J. R., Seckinger, A., Kovacic, N., Nguyen, A., Mohanty, S. T., Pettitt, J. A., Xiao, Y., Corr, A. P., Seeliger, C., Novotny, M., Lasken, R. S., Nguyen, T. V., Oyajobi, B. O., Aftab, D., Swarbrick, A., Parker, B., Hewett, D. R., Hose, D., Vanderkerken, K., Zannettino, A. C. W., Amit, I., Phan, T. G. and Croucher, P. I. (2019). "A niche-dependent myeloid transcriptome signature defines dormant myeloma cells." Blood 134(1): 30-43. www.ncbi.nlm.nih.gov/pubmed/31023703.

Merz, M., Hielscher, T., Schult, D., Mai, E. K., Raab, M. S., Hillengass, J., Seckinger, A., Hose, D., Granzow, M., Jauch, A. and Goldschmidt, H. (2019). "Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma." Leukemia. www.ncbi.nlm.nih.gov/pubmed/31712777.

Schmidt, A. F., Holmes, M. V., Preiss, D., Swerdlow, D. I., Denaxas, S., Fatemifar, G., Faraway, R., Finan, C., Valentine, D., Fairhurst-Hunter, Z., Hartwig, F. P., Horta, B. L., Hypponen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Lill, C. M., Coassin, S., Willeit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., van der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R. A., Luan, J., Bobak, M., Malyutina, S., Pajak, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Jess, T., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Lester, K. H., Larson, E. B., Crosslin, D. R., de Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., Scott, R., Schofield, P., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., van der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Lifelines Cohort, a., Christen, T., Mook-Kanamori, D. O., Consortium, I., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dorr, M., Lerch, M. M., Volker, U., Volzke, H., Ward, J., Pell, J. P., Meade, T., Christophersen, I. E., Maitland-van der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Roussel, R., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Hopewell, J. C., Seshadri, S., ISGC, M. C. o. t., Dale, C., Costa, R. P. E., Ridker, P. M., Chasman, D. I., Reiner, A. P., Ritchie, M. D., Lange, L. A., Cornish, A. J., Dobbins, S. E., Hemminki, K., Kinnersley, B., Sanson, M., Labreche, K., Simon, M., Bondy, M., Law, P., Speedy, H., Allan, J., Li, N., Went, M., Weinhold, N., Morgan, G., Sonneveld, P., Nilsson, B., Goldschmidt, H., Sud, A., Engert, A., Hansson, M., Hemingway, H., Asselbergs, F. W., Patel, R. S., Keating, B. J., Sattar, N., Houlston, R., Casas, J. P. and Hingorani, A. D. (2019). "Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9." BMC Cardiovasc Disord 19(1): 240. www.ncbi.nlm.nih.gov/pubmed/31664920.

Thomsen, H., Chattopadhyay, S., Weinhold, N., Vodicka, P., Vodickova, L., Hoffmann, P., Nothen, M. M., Jockel, K. H., Langer, C., Hajek, R., Hallmans, G., Pettersson-Kymmer, U., Ohlsson, C., Spath, F., Houlston, R., Goldschmidt, H., Hemminki, K. and Forsti, A. (2019). "Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma." Leukemia 33(7): 1817-1821. www.ncbi.nlm.nih.gov/pubmed/30737484.

2018

Ali, M., Ajore, R., Wihlborg, A.-K., Niroula, A., Swaminathan, B., Johnsson, E., Stephens, O. W., Morgan, G., Meissner, T., Turesson, I., Goldschmidt, H., Mellqvist, U.-H., Gullberg, U., Hansson, M., Hemminki, K., Nahi, H., Waage, A., Weinhold, N. and Nilsson, B. (2018). "The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression." Nature Communications 9(1): 1649. www.ncbi.nlm.nih.gov/pubmed/29695719.

Bruyer, A., Maes, K., Herviou, L., Kassambara, A., Seckinger, A., Cartron, G., Rème, T., Robert, N., Requirand, G., Boireau, S., Müller-Tidow, C., Veyrune, J.-L., Vincent, L., Bouhya, S., Goldschmidt, H., Vanderkerken, K., Hose, D., Klein, B., De Bruyne, E. and Moreaux, J. (2018). "DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells." British Journal of Cancer 118(8): 1062-1073. www.ncbi.nlm.nih.gov/pubmed/29500406.

Campo, C., da Silva Filho, M. I., Weinhold, N., Mahmoudpour, S. H., Goldschmidt, H., Hemminki, K., Merz, M. and Försti, A. (2018). "Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients." Hematological Oncology 36(1): 232-237. www.ncbi.nlm.nih.gov/pubmed/28317148.

Chattopadhyay, S., Thomsen, H., da Silva Filho, M. I., Weinhold, N., Hoffmann, P., Nöthen, M. M., Marina, A., Jöckel, K.-H., Schmidt, B., Pechlivanis, S., Langer, C., Goldschmidt, H., Hemminki, K. and Försti, A. (2018). "Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study." Molecular Medicine (Cambridge, Mass.) 24(1): 30. www.ncbi.nlm.nih.gov/pubmed/30134812.

Chattopadhyay, S., Yu, H., Sud, A., Sundquist, J., Försti, A., Hemminki, A. and Hemminki, K. (2018). "Multiple myeloma: family history and mortality in second primary cancers." Blood Cancer Journal 8(8): 75. www.ncbi.nlm.nih.gov/pubmed/30087319.

Ganzinger, M., Gietzelt, M., Karmen, C., Flores, B. and Knaup, P. (2018). "Implementing Systems Medicine: A Medical Informatics Perspective." Studies in Health Technology and Informatics 247: 875-879. www.ncbi.nlm.nih.gov/pubmed/29678086.

Gu, C., Holman, C., Sompallae, R., Jing, X., Tomasson, M., Hose, D., Seckinger, A., Zhan, F., Tricot, G., Goldschmidt, H., Yang, Y. and Janz, S. (2018). "Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome." Blood Cancer Journal 8(2): 22. www.ncbi.nlm.nih.gov/pubmed/29449574.

Herviou, L., Kassambara, A., Boireau, S., Robert, N., Requirand, G., Müller-Tidow, C., Vincent, L., Seckinger, A., Goldschmidt, H., Cartron, G., Hose, D., Cavalli, G. and Moreaux, J. (2018). "PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs." Clinical Epigenetics 10(1): 121. www.ncbi.nlm.nih.gov/pubmed/30285865.

Lehners, N., Becker, N., Benner, A., Pritsch, M., Löpprich, M., Mai, E. K., Hillengass, J., Goldschmidt, H. and Raab, M.-S. (2018). "Analysis of long-term survival in multiple myeloma after first-line autologous stem cell transplantation: impact of clinical risk factors and sustained response." Cancer Medicine 7(2): 307-316. www.ncbi.nlm.nih.gov/pubmed/29282899.

Mahmoudpour, S. H., Bandapalli, O. R., da Silva Filho, M. I., Campo, C., Hemminki, K., Goldschmidt, H., Merz, M. and Försti, A. (2018). "Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients." BMC cancer 18(1): 820. www.ncbi.nlm.nih.gov/pubmed/30111286.

Mai, E. K., Haas, E.-M., Lücke, S., Löpprich, M., Kunz, C., Pritsch, M., Knaup-Gregori, P., Raab, M. S., Schlenzka, J., Bertsch, U., Hillengass, J. and Goldschmidt, H. (2018). "A systematic classification of death causes in multiple myeloma." Blood Cancer Journal 8(3): 30. www.ncbi.nlm.nih.gov/pubmed/29520024.

Merz, M., Hielscher, T., Hoffmann, K., Seckinger, A., Hose, D., Raab, M. S., Hillengass, J., Jauch, A. and Goldschmidt, H. (2018). "Cytogenetic abnormalities in monoclonal gammopathy of undetermined significance." Leukemia 32(12): 2717-2719. www.ncbi.nlm.nih.gov/pubmed/29977018.

Merz, M., Jauch, A., Hielscher, T., Bochtler, T., Schönland, S. O., Seckinger, A., Hose, D., Bertsch, U., Neben, K., Raab, M. S., Hillengass, J., Salwender, H., Blau, I. W., Lindemann, H.-W., Schmidt-Wolf, I. G. H., Scheid, C., Haenel, M., Weisel, K. C. and Goldschmidt, H. (2018). "Prognostic significance of cytogenetic heterogeneity in patients with newly diagnosed multiple myeloma." Blood Advances 2(1): 1-9. www.ncbi.nlm.nih.gov/pubmed/29344579.

Mohr, M., Hose, D., Seckinger, A. and Marciniak-Czochra, A. (2018). "Quantification of plasma cell dynamics using mathematical modelling." Royal Society Open Science 5(1): 170759. www.ncbi.nlm.nih.gov/pubmed/29410799.

Seckinger, A., Bähr-Ivacevic, T., Benes, V. and Hose, D. (2018). RNA-Sequencing from Low-Input Material in Multiple Myeloma for Application in Clinical Routine. Multiple Myeloma, Humana Press, New York, NY: 97-115. link.springer.com/protocol/10.1007/978-1-4939-7865-6_7

Seckinger, A., Hillengass, J., Emde, M., Beck, S., Kimmich, C., Dittrich, T., Hundemer, M., Jauch, A., Hegenbart, U., Raab, M. S., Ho, A. D., Schonland, S. and Hose, D. (2018). "CD38 as Immunotherapeutic Target in Light Chain Amyloidosis and Multiple Myeloma-Association With Molecular Entities, Risk, Survival, and Mechanisms of Upfront Resistance." Front Immunol 9: 1676. www.ncbi.nlm.nih.gov/pubmed/30079070.

Stoyan, D., Pommerening, A., Hummel, M. and Kopp-Schneider, A. (2018). "Multiple-rater kappas for binary data: Models and interpretation." Biometrical Journal. Biometrische Zeitschrift 60(2): 381-394. www.ncbi.nlm.nih.gov/pubmed/29280179.

Sud, A., Thomsen, H., Orlando, G., Foersti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., Hoffmann, P., Noethen, M. M., Joeckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K. and Houlston, R. S. (2018). "Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma." Blood 132(19): 2040-2052.

Went, M., Sud, A., Försti, A., Halvarsson, B.-M., Weinhold, N., Kimber, S., van Duin, M., Thorleifsson, G., Holroyd, A., Johnson, D. C., Li, N., Orlando, G., Law, P. J., Ali, M., Chen, B., Mitchell, J. S., Gudbjartsson, D. F., Kuiper, R., Stephens, O. W., Bertsch, U., Broderick, P., Campo, C., Bandapalli, O. R., Einsele, H., Gregory, W. A., Gullberg, U., Hillengass, J., Hoffmann, P., Jackson, G. H., Jöckel, K.-H., Johnsson, E., Kristinsson, S. Y., Mellqvist, U.-H., Nahi, H., Easton, D., Pharoah, P., Dunning, A., Peto, J., Canzian, F., Swerdlow, A., Eeles, R. A., Kote-Jarai, Z., Muir, K., Pashayan, N., Nickel, J., Nöthen, M. M., Rafnar, T., Ross, F. M., da Silva Filho, M. I., Thomsen, H., Turesson, I., Vangsted, A., Andersen, N. F., Waage, A., Walker, B. A., Wihlborg, A.-K., Broyl, A., Davies, F. E., Thorsteinsdottir, U., Langer, C., Hansson, M., Goldschmidt, H., Kaiser, M., Sonneveld, P., Stefansson, K., Morgan, G. J., Hemminki, K., Nilsson, B., Houlston, R. S. and consortium, P. (2018). "Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma." Nature Communications 9(1): 3707. www.ncbi.nlm.nih.gov/pubmed/30213928.

Went, M., Sud, A., Speedy, H., Sunter, N. J., Försti, A., Law, P. J., Johnson, D. C., Mirabella, F., Holroyd, A., Li, N., Orlando, G., Weinhold, N., van Duin, M., Chen, B., Mitchell, J. S., Mansouri, L., Juliusson, G., Smedby, K. E., Jayne, S., Majid, A., Dearden, C., Allsup, D. J., Bailey, J. R., Pratt, G., Pepper, C., Fegan, C., Rosenquist, R., Kuiper, R., Stephens, O. W., Bertsch, U., Broderick, P., Einsele, H., Gregory, W. M., Hillengass, J., Hoffmann, P., Jackson, G. H., Jöckel, K.-H., Nickel, J., Nöthen, M. M., da Silva Filho, M. I., Thomsen, H., Walker, B. A., Broyl, A., Davies, F. E., Hansson, M., Goldschmidt, H., Dyer, M. J. S., Kaiser, M., Sonneveld, P., Morgan, G. J., Hemminki, K., Nilsson, B., Catovsky, D., Allan, J. M. and Houlston, R. S. (2018). "Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology." Blood Cancer Journal 9(1): 1. www.ncbi.nlm.nih.gov/pubmed/30602759.

Yadav, P., Merz, M., Mai, E. K., Försti, A., Jauch, A., Goldschmidt, H. and Hemminki, K. (2018). "Cytogenetic aberrations in multiple myeloma are associated with shifts in serum immunoglobulin isotypes distribution and levels." Haematologica 103(4): e162-e164. www.ncbi.nlm.nih.gov/pubmed/29419430.

2017

da Silva Filho, M.I., Försti, A., Weinhold, N., Meziane, I., Campo, C., Huhn, S., Nickel, J., Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Landi, S., Mitchell, J.S., Johnson, D., Morgan, G.J., Houlston, R., Goldschmidt, H., Jauch, A., Milani, P., Merlini, G., Rowcieno, D., Hawkins, P., Hegenbart, U., Palladini, G., Wechalekar, A., Schönland, S.O., Hemminki, K., 2017. Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma. Leukemia 31, 1735–1742. doi.org/10.1038/leu.2016.387

De Veirman, K., De Beule, N., Maes, K., Menu, E., De Bruyne, E., De Raeve, H., Fostier, K., Moreaux, J., Kassambara, A., Hose, D., Heusschen, R., Eriksson, H., Vanderkerken, K., Van Valckenborgh, E., 2017. Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion. Cancer Immunol Res 5, 839–846. doi.org/10.1158/2326-6066.CIR-17-0192

Granzow, M., Hegenbart, U., Hinderhofer, K., Hose, D., Seckinger, A., Bochtler, T., Hemminki, K., Goldschmidt, H., Schönland, S.O., Jauch, A., 2017. Novel recurrent chromosomal aberrations detected in clonal plasma cells of light chain amyloidosis patients show potential adverse prognostic effect: first results from a genome-wide copy number array analysis. Haematologica 102, 1281–1290. doi.org/10.3324/haematol.2016.160721

Hummel, M., Edelmann, D., Kopp-Schneider, A., 2017. Clustering of samples and variables with mixed-type data. PLoS ONE 12, e0188274. doi.org/10.1371/journal.pone.0188274

Law, P.J., Sud, A., Mitchell, J.S., Henrion, M., Orlando, G., Lenive, O., Broderick, P., Speedy, H.E., Johnson, D.C., Kaiser, M., Weinhold, N., Cooke, R., Sunter, N.J., Jackson, G.H., Summerfield, G., Harris, R.J., Pettitt, A.R., Allsup, D.J., Carmichael, J., Bailey, J.R., Pratt, G., Rahman, T., Pepper, C., Fegan, C., von Strandmann, E.P., Engert, A., Försti, A., Chen, B., Filho, M.I. da S., Thomsen, H., Hoffmann, P., Noethen, M.M., Eisele, L., Jöckel, K.-H., Allan, J.M., Swerdlow, A.J., Goldschmidt, H., Catovsky, D., Morgan, G.J., Hemminki, K., Houlston, R.S., 2017. Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci. Sci Rep 7, 41071. doi.org/10.1038/srep41071

Li, N., Johnson, D.C., Weinhold, N., Kimber, S., Dobbins, S.E., Mitchell, J.S., Kinnersley, B., Sud, A., Law, P.J., Orlando, G., Scales, M., Wardell, C.P., Försti, A., Hoang, P.H., Went, M., Holroyd, A., Hariri, F., Pastinen, T., Meissner, T., Goldschmidt, H., Hemminki, K., Morgan, G.J., Kaiser, M., Houlston, R.S., 2017. Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism. Cell Rep 20, 2556–2564. doi.org/10.1016/j.celrep.2017.08.062

McDonald, M.M., Reagan, M.R., Youlten, S.E., Mohanty, S.T., Seckinger, A., Terry, R.L., Pettitt, J.A., Simic, M.K., Cheng, T.L., Morse, A., Le, L.M.T., Abi-Hanna, D., Kramer, I., Falank, C., Fairfield, H., Ghobrial, I.M., Baldock, P.A., Little, D.G., Kneissel, M., Vanderkerken, K., Bassett, J.H.D., Williams, G.R., Oyajobi, B.O., Hose, D., Phan, T.G., Croucher, P.I., 2017. Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood 129, 3452–3464. doi.org/10.1182/blood-2017-03-773341

Merz, M., Jauch, A., Hielscher, T., Mai, E.K., Seckinger, A., Hose, D., Bertsch, U., Neben, K., Raab, M.S., Salwender, H., Blau, I.W., Lindemann, H.-W., Schmidt-Wolf, I., Scheid, C., Haenel, M., Weisel, K., Goldschmidt, H., Hillengass, J., 2017. Longitudinal fluorescence in situ hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation. Haematologica 102, 1432–1438. doi.org/10.3324/haematol.2017.168005

Meziane, I., Huhn, S., Filho, M.I. da S., Weinhold, N., Campo, C., Nickel, J., Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Landi, S., Mitchell, J.S., Johnson, D., Jauch, A., Morgan, G.J., Houlston, R., Goldschmidt, H., Milani, P., Merlini, G., Rowcieno, D., Hawkins, P., Hegenbart, U., Palladini, G., Wechalekar, A., Försti, A., Schönland, S.O., Hemminki, K., 2017. Genome-wide association study of clinical parameters in immunoglobulin light chain amyloidosis in three patient cohorts. Haematologica 102, e411–e414. doi.org/10.3324/haematol.2017.171108

Schmitt, M., Hückelhoven, A.G., Hundemer, M., Schmitt, A., Lipp, S., Emde, M., Salwender, H., Hänel, M., Weisel, K., Bertsch, U., Dürig, J., Ho, A.D., Blau, I.W., Goldschmidt, H., Seckinger, A., Hose, D., 2017. Frequency of expression and generation of T-cell responses against antigens on multiple myeloma cells in patients included in the GMMG-MM5 trial. Oncotarget 8, 84847–84862. doi.org/10.18632/oncotarget.11215

Seckinger, A., Delgado, J.A., Moser, S., Moreno, L., Neuber, B., Grab, A., Lipp, S., Merino, J., Prosper, F., Emde, M., Delon, C., Latzko, M., Gianotti, R., Lüoend, R., Murr, R., Hosse, R.J., Harnisch, L.J., Bacac, M., Fauti, T., Klein, C., Zabaleta, A., Hillengass, J., Cavalcanti-Adam, E.A., Ho, A.D., Hundemer, M., Miguel, J.F.S., Strein, K., Umaña, P., Hose, D., Paiva, B., Vu, M.D., 2017. Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment. Cancer Cell 0. doi.org/10.1016/j.ccell.2017.02.002

Sud, A., Thomsen, H., Law, P.J., Försti, A., Filho, M.I. da S., Holroyd, A., Broderick, P., Orlando, G., Lenive, O., Wright, L., Cooke, R., Easton, D., Pharoah, P., Dunning, A., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Zs., Muir, K., Pashayan, N., PRACTICAL consortium, Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Strandmann, E.P. von, Lightfoot, T., Kane, E., Roman, E., Lake, A., Montgomery, D., Jarrett, R.F., Swerdlow, A.J., Engert, A., Orr, N., Hemminki, K., Houlston, R.S., 2017. Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nat Commun 8, 1892. doi.org/10.1038/s41467-017-00320-1

Thomsen, H., Campo, C., Weinhold, N., da Silva Filho, M.I., Pour, L., Gregora, E., Vodicka, P., Vodickova, L., Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Langer, C., Hajek, R., Goldschmidt, H., Hemminki, K., Försti, A., 2017. Genomewide association study on monoclonal gammopathy of unknown significance (MGUS). Eur. J. Haematol. 99, 70–79. doi.org/10.1111/ejh.12892

Went, M., Sud, A., Law, P.J., Johnson, D.C., Weinhold, N., Försti, A., van Duin, M., Mitchell, J.S., Chen, B., Kuiper, R., Stephens, O.W., Bertsch, U., Campo, C., Einsele, H., Gregory, W.M., Henrion, M., Hillengass, J., Hoffmann, P., Jackson, G.H., Lenive, O., Nickel, J., Nöthen, M.M., da Silva Filho, M.I., Thomsen, H., Walker, B.A., Broyl, A., Davies, F.E., Langer, C., Hansson, M., Kaiser, M., Sonneveld, P., Goldschmidt, H., Hemminki, K., Nilsson, B., Morgan, G.J., Houlston, R.S., 2017. Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach. Blood Cancer J 7, e573. doi.org/10.1038/bcj.2017.48

2016

Frank, C., Fallah, M., Chen, T., Mai, E.K., Sundquist, J., Försti, A., Hemminki, K., 2016. Search for familial clustering of multiple myeloma with any cancer. Leukemia 30, 627–632. doi.org/10.1038/leu.2015.279

Gietzelt, M., Höfer, T., Knaup-Gregori, P., König, R., Löpprich, M., Poos, A., Ganzinger, M., 2016. The Use of Tools, Modelling Methods, Data Types, and Endpoints in Systems Medicine: A Survey on Projects of the German e:Med-Programme. Stud Health Technol Inform 228, 670–674. doi.org/10.3233/978-1-61499-678-1-670

Gietzelt, M., Löpprich, M., Karmen, C., Knaup, P., Ganzinger, M., 2016. Models and Data Sources Used in Systems Medicine. A Systematic Literature Review. Methods Inf Med 55, 107–113. doi.org/10.3414/ME15-01-0151

Gu, C., Yang, Y., Sompallae, R., Xu, H., Tompkins, V.S., Holman, C., Hose, D., Goldschmidt, H., Tricot, G., Zhan, F., Janz, S., 2016. FOXM1 is a therapeutic target for high-risk multiple myeloma. Leukemia 30, 873–882. doi.org/10.1038/leu.2015.334

Johnson, D.C., Weinhold, N., Mitchell, J., Chen, B., Stephens, O.W., Försti, A., Nickel, J., Kaiser, M., Gregory, W.A., Cairns, D., Jackson, G.H., Hoffmann, P., Noethen, M.M., Hillengass, J., Bertsch, U., Barlogie, B., Davis, F.E., Hemminki, K., Goldschmidt, H., Houlston, R.S., Morgan, G.J., 2016. Genetic factors influencing the risk of multiple myeloma bone disease. Leukemia 30, 883–888. doi.org/10.1038/leu.2015.342

Johnson, D.C., Weinhold, N., Mitchell, J.S., Chen, B., Kaiser, M., Begum, D.B., Hillengass, J., Bertsch, U., Gregory, W.A., Cairns, D., Jackson, G.H., Försti, A., Nickel, J., Hoffmann, P., Nöethen, M.M., Stephens, O.W., Barlogie, B., Davis, F.E., Hemminki, K., Goldschmidt, H., Houlston, R.S., Morgan, G.J., 2016. Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma. Nat Commun 7, 10290. doi.org/10.1038/ncomms10290

Mitchell, J.S., Li, N., Weinhold, N., Försti, A., Ali, M., van Duin, M., Thorleifsson, G., Johnson, D.C., Chen, B., Halvarsson, B.-M., Gudbjartsson, D.F., Kuiper, R., Stephens, O.W., Bertsch, U., Broderick, P., Campo, C., Einsele, H., Gregory, W.A., Gullberg, U., Henrion, M., Hillengass, J., Hoffmann, P., Jackson, G.H., Johnsson, E., Jöud, M., Kristinsson, S.Y., Lenhoff, S., Lenive, O., Mellqvist, U.-H., Migliorini, G., Nahi, H., Nelander, S., Nickel, J., Nöthen, M.M., Rafnar, T., Ross, F.M., da Silva Filho, M.I., Swaminathan, B., Thomsen, H., Turesson, I., Vangsted, A., Vogel, U., Waage, A., Walker, B.A., Wihlborg, A.-K., Broyl, A., Davies, F.E., Thorsteinsdottir, U., Langer, C., Hansson, M., Kaiser, M., Sonneveld, P., Stefansson, K., Morgan, G.J., Goldschmidt, H., Hemminki, K., Nilsson, B., Houlston, R.S., 2016. Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Nat Commun 7, 12050. doi.org/10.1038/ncomms12050

Weinhold, N., Kirn, D., Seckinger, A., Hielscher, T., Granzow, M., Bertsch, U., Egerer, G., Salwender, H., Blau, I.W., Weisel, K., Hillengass, J., Raab, M.S., Hose, D., Goldschmidt, H., Jauch, A., 2016. Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma. Haematologica 101, e116-119. doi.org/10.3324/haematol.2015.136929

2015

Bolomsky, A., Hose, D., Schreder, M., Seckinger, A., Lipp, S., Klein, B., Heintel, D., Ludwig, H., Zojer, N., 2015. Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma. J Hematol Oncol 8, 10. doi.org/10.1186/s13045-014-0105-1

Cowan, G., Weston-Bell, N.J., Bryant, D., Seckinger, A., Hose, D., Zojer, N., Sahota, S.S., 2015. Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma. Oncotarget 6, 13229–13240. doi.org/10.18632/oncotarget.3644

Fichtner, S., Hose, D., Engelhardt, M., Meißner, T., Neuber, B., Krasniqi, F., Raab, M., Schönland, S., Ho, A.D., Goldschmidt, H., Hundemer, M., 2015. Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma. Clin. Cancer Res. 21, 1712–1721. doi.org/10.1158/1078-0432.CCR-14-1618

Ganzinger, M., Gietzelt, M., Karmen, C., Firnkorn, D., Knaup, P., 2015a. An IT Architecture for Systems Medicine. Stud Health Technol Inform 210, 185–189. doi.org/10.3233/978-1-61499-512-8-185

Ganzinger, M., Haux, C., Karmen, C., Wetter, T., Knaup, P., 2015b. Systems Medicine for Multiple Myeloma: A Review on Decision Support Systems. Stud Health Technol Inform 216, 951. doi.org/10.3233/978-1-61499-564-7-951

Kuiper, R., van Duin, M., van Vliet, M.H., Broijl, A., van der Holt, B., El Jarari, L., van Beers, E.H., Mulligan, G., Avet-Loiseau, H., Gregory, W.M., Morgan, G., Goldschmidt, H., Lokhorst, H.M., Sonneveld, P., 2015. Prediction of high- and low-risk multiple myeloma based on gene expression and the International Staging System. Blood 126, 1996–2004. doi.org/10.1182/blood-2015-05-644039

Maes, K., De Smedt, E., Kassambara, A., Hose, D., Seckinger, A., Van Valckenborgh, E., Menu, E., Klein, B., Vanderkerken, K., Moreaux, J., De Bruyne, E., 2015. In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma. Oncotarget 6, 3319–3334. doi.org/10.18632/oncotarget.3207

Mai, E.K., Hielscher, T., Kloth, J.K., Merz, M., Shah, S., Raab, M.S., Hillengass, M., Wagner, B., Jauch, A., Hose, D., Weber, M.-A., Delorme, S., Goldschmidt, H., Hillengass, J., 2015. A magnetic resonance imaging-based prognostic scoring system to predict outcome in transplant-eligible patients with multiple myeloma. Haematologica 100, 818–825. doi.org/10.3324/haematol.2015.124115

Meißner, T., Seckinger, A., Hemminki, K., Bertsch, U., Foersti, A., Haenel, M., Duering, J., Salwender, H., Goldschmidt, H., Morgan, G.J., Hose, D., Weinhold, N., 2015. Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells. BMC Med Genomics 8, 85. doi.org/10.1186/s12920-015-0161-6

Weinhold, N., Meissner, T., Johnson, D.C., Seckinger, A., Moreaux, J., Försti, A., Chen, B., Nickel, J., Chubb, D., Rawstron, A.C., Doughty, C., Dahir, N.B., Begum, D.B., Young, K., Walker, B.A., Hoffmann, P., Nöthen, M.M., Davies, F.E., Klein, B., Goldschmidt, H., Morgan, G.J., Houlston, R.S., Hose, D., Hemminki, K., 2015. The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells. Haematologica 100, e110-113. https://doi.org/10.3324/haematol.2014.118786

2014

Ganzinger, M., Gietzelt, M., Karmen, C., Firnkorn, D., Knaup, P., 2015. An IT Architecture for Systems Medicine. Stud Health Technol Inform 210, 185–189. doi.org/10.3233/978-1-61499-512-8-185

Karmen, C., Ganzinger, M., Kohl, C.D., Firnkorn, D., Knaup-Gregori, P., 2014. A framework for integrating heterogeneous clinical data for a disease area into a central data warehouse. Stud Health Technol Inform 205, 1060–1064. doi.org/10.3233/978-1-61499-432-9-1060

Morgan, G.J., Johnson, D.C., Weinhold, N., Goldschmidt, H., Landgren, O., Lynch, H.T., Hemminki, K., Houlston, R.S., 2014. Inherited genetic susceptibility to multiple myeloma. Leukemia 28, 518–524. doi.org/10.1038/leu.2013.344

Weinhold, N., Försti, A., da Silva Filho, M.I., Nickel, J., Campo, C., Hoffmann, P., Nöthen, M.M., Hose, D., Goldschmidt, H., Jauch, A., Langer, C., Hegenbart, U., Schönland, S.O., Hemminki, K., 2014. Immunoglobulin light-chain amyloidosis shares genetic susceptibility with multiple myeloma. Leukemia 28, 2254–2256. doi.org/10.1038/leu.2014.208

Weinhold, N., Johnson, D.C., Rawstron, A.C., Försti, A., Doughty, C., Vijayakrishnan, J., Broderick, P., Dahir, N.B., Begum, D.B., Hosking, F.J., Yong, K., Walker, B.A., Hoffmann, P., Mühleisen, T.W., Langer, C., Dörner, E., Jöckel, K.-H., Eisele, L., Nöthen, M.M., Hose, D., Davies, F.E., Goldschmidt, H., Morgan, G.J., Hemminki, K., Houlston, R.S., 2014. Inherited genetic susceptibility to monoclonal gammopathy of unknown significance. Blood 123, 2513–2517; quiz 2593. doi.org/10.1182/blood-2013-10-532283

2013

Chubb, D., Weinhold, N., Broderick, P., Chen, B., Johnson, D.C., Försti, A., Vijayakrishnan, J., Migliorini, G., Dobbins, S.E., Holroyd, A., Hose, D., Walker, B.A., Davies, F.E., Gregory, W.A., Jackson, G.H., Irving, J.A., Pratt, G., Fegan, C., Fenton, J.A.L., Neben, K., Hoffmann, P., Nöthen, M.M., Mühleisen, T.W., Eisele, L., Ross, F.M., Straka, C., Einsele, H., Langer, C., Dörner, E., Allan, J.M., Jauch, A., Morgan, G.J., Hemminki, K., Houlston, R.S., Goldschmidt, H., 2013. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat. Genet. 45, 1221–1225. doi.org/10.1038/ng.2733

Moehler, T.M., Seckinger, A., Hose, D., Andrulis, M., Moreaux, J., Hielscher, T., Willhauck-Fleckenstein, M., Merling, A., Bertsch, U., Jauch, A., Goldschmidt, H., Klein, B., Schwartz-Albiez, R., 2013. The glycome of normal and malignant plasma cells. PLoS ONE 8, e83719. doi.org/10.1371/journal.pone.0083719

 

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