Multiscale HCC

Publications

2018

Frey, N., Venturelli, S., Zender, L.Bitzer, M., 2018. Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics. Nat Rev Gastroenterol Hepatol, 15(2), 81-95. doi.org/10.1038/nrgastro.2017.146

Mohr, C., Friedrich, A., Wojnar, D., Kenar, E., Polatkan, A. C., Codrea, M. C., Czemmel, S., Kohlbacher, O.Nahnsen, S., 2018. qPortal: A platform for data-driven biomedical research. PLoS ONE, 13(1), e0191603. doi.org/10.1371/journal.pone.0191603

Seehawer, M., Heinzmann, F., D'Artista, L., Harbig, J., Roux, P.-F., Hoenicke, L., Dang, H., Klotz, S., Robinson, L., Doré, G., Rozenblum, N., Kang, T.-W., Chawla, R., Buch, T., Vucur, M., Roth, M., Zuber, J., Luedde, T., Sipos, B., Longerich, T., Heikenwälder, M., Wang, X. W., Bischof, O.Zender, L., 2018. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature. doi.org/10.1038/s41586-018-0519-y

Thaiss, W. M., Haberland, U., Kaufmann, S., Hepp, T., Schulze, M., Blum, A. C., Ketelsen, D., Nikolaou, K., Horger, M.Sauter, A. W., 2018. Dose Optimization of Perfusion-derived Response Assessment in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: Comparison of Volume Perfusion CT and Iodine Concentration. Academic Radiology. doi.org/10.1016/j.acra.2018.09.026

 

2017

Kurucay, M., Kloth, C., Kaufmann, S., Nikolaou, K., Bösmüller, H., Horger, M., Thaiss, W.M., 2017. Multiparametric imaging for detection and characterization of hepatocellular carcinoma using gadoxetic acid-enhanced MRI and perfusion-CT: which parameters work best? Cancer Imaging 17, 18. doi.org/10.1186/s40644-017-0121-9

Perfahl, H., Hughes, B.D., Alarcón, T., Maini, P.K., Lloyd, M.C., Reuss, M., Byrne, H.M., 2017. 3D hybrid modelling of vascular network formation. Journal of Theoretical Biology 414, 254–268. doi.org/10.1016/j.jtbi.2016.11.013

Schroeder, C.M., Hilke, F.J., Löffler, M.W., Bitzer, M., Lenz, F., Sturm, M., 2017. A comprehensive quality control workflow for paired tumor-normal NGS experiments. Bioinformatics 33, 1721–1722. doi.org/10.1093/bioinformatics/btx032

2016

Dauch, D., Rudalska, R., Cossa, G., Nault, J.-C., Kang, T.-W., Wuestefeld, T., Hohmeyer, A., Imbeaud, S., Yevsa, T., Hoenicke, L., Pantsar, T., Bozko, P., Malek, N.P., Longerich, T., Laufer, S., Poso, A., Zucman-Rossi, J., Eilers, M., Zender, L., 2016. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat. Med. 22, 744–753. doi.org/10.1038/nm.4107

Eggert, T., Wolter, K., Ji, J., Ma, C., Yevsa, T., Klotz, S., Medina-Echeverz, J., Longerich, T., Forgues, M., Reisinger, F., Heikenwalder, M., Wang, X.W., Zender, L., Greten, T.F., 2016. Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. Cancer Cell 30, 533–547. doi.org/10.1016/j.ccell.2016.09.003

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M.P., Matheson, N.J., Patten, D.A., Shetty, S., Parry, A.J., Menon, S., Salama, R., Antrobus, R., Tomimatsu, K., Howat, W., Lehner, P.J., Zender, L., Narita, M., 2016. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat. Cell Biol. 18, 979–992. doi.org/10.1038/ncb3397

Syha, R., Grözinger, G., Grosse, U., Maurer, M., Zender, L., Horger, M., Nikolaou, K., Ketelsen, D., 2016. Parenchymal Blood Volume Assessed by C-Arm-Based Computed Tomography in Immediate Posttreatment Evaluation of Drug-Eluting Bead Transarterial Chemoembolization in Hepatocellular Carcinoma. Invest Radiol 51, 121–126. doi.org/10.1097/RLI.0000000000000215

Thaiss, W.M., Kaufmann, S., Kloth, C., Nikolaou, K., Bösmüller, H., Horger, M., 2016. VEGFR-2 expression in HCC, dysplastic and regenerative liver nodules, and correlation with pre-biopsy Dynamic Contrast Enhanced CT. Eur J Radiol 85, 2036–2041. https://doi.org/10.1016/j.ejrad.2016.09.012

2015

Kaufmann, S., Horger, T., Oelker, A., Beck, S., Schulze, M., Nikolaou, K., Ketelsen, D., Horger, M., 2015a. Volume perfusion computed tomography (VPCT)-based evaluation of response to TACE using two different sized drug eluting beads in patients with nonresectable hepatocellular carcinoma: Impact on tumor and liver parenchymal vascularisation. Eur J Radiol 84, 2548–2554. doi.org/10.1016/j.ejrad.2015.09.009

Kaufmann, S., Horger, T., Oelker, A., Kloth, C., Nikolaou, K., Schulze, M., Horger, M., 2015b. Characterization of hepatocellular carcinoma (HCC) lesions using a novel CT-based volume perfusion (VPCT) technique. Eur J Radiol 84, 1029–1035. doi.org/10.1016/j.ejrad.2015.02.020

Schneeweiß, S., Horger, M., Ketelsen, D., Ioanoviciu, S.D., 2015. [Complications after TACE in HCC]. Rofo 36, 79–82. https://doi.org/10.1055/s-0034-1369532

2014

Dengel, B.-S., Perfahl, H., Galliani, S., Reuss, M., 2015. The VasCan Project: Simulation of Vascular Tumour Growth and Angiogenesis Using a Multiscale Model, in: High Performance Computing in Science and Engineering ‘14. Springer, Cham, pp. 683–691. https://doi.org/10.1007/978-3-319-10810-0_45