PANC-STRAT

Brindl, N., H. Boekhoff, A. S. Bauer, M. M. Gaida, H. T. Dang, J. Kaiser, J. D. Hoheisel, and K. Felix (2022). "Use of Autoreactive Antibodies in Blood of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN) for Grade Distinction and Detection of Malignancy." Cancers 14(15): 3562. doi.org/10.3390/cancers14153562.

Krebs, N., L. Klein, F. Wegwitz, E. Espinet, H. C. Maurer, M. Tu, F. Penz, S. Küffer, X. Xu, H. Bohnenberger, S. Cameron, M. Brunner, A. Neesse, U. Kishore, E. Hessmann, A. Trumpp, P. Ströbel, R. A. Brekken, V. Ellenrieder, and S. K. Singh (2022). "Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer." JCI Insight 7(16). doi.org/10.1172/jci.insight.154475.

Schuth, S., S. Le Blanc, T. G. Krieger, J. Jabs, M. Schenk, N. A. Giese, M. W. Büchler, R. Eils, C. Conrad, and O. Strobel (2022). "Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system." J Exp Clin Cancer Res 41(1): 1–14. doi.org/10.1186/s13046-022-02519-7.

Corradi, C., M. Gentiluomo, L. Gajdán, G. M. Cavestro, E. Kreivenaite, G. Di Franco, C. Sperti, M. Giaccherini, M. C. Petrone, F. Tavano, D. Gioffreda, L. Morelli, P. Soucek, A. Andriulli, J. R. Izbicki, N. Napoli, E. Małecka-Panas, P. Hegyi, J. P. Neoptolemos, S. Landi, Y. Vashist, C. Pasquali, Y. Lu, K. Cervena, G. E. Theodoropoulos, S. Moz, G. Capurso, O. Strobel, S. Carrara, T. Hackert, V. Hlavac, L. Archibugi, M. Oliverius, G. Vanella, P. Vodicka, P. G. Arcidiacono, R. Pezzilli, A. C. Milanetto, R. T. Lawlor, A. Ivanauskas, A. Szentesi, J. Kupcinskas, S. G. G. Testoni, M. Lovecek, M. Nentwich, M. Gazouli, C. Luchini, R. A. Zuppardo, E. Darvasi, H. Brenner, C. Gheorghe, K. Jamroziak, F. Canzian, and D. Campa (2021). "Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility." Int. J. Cancer 148(11): 2779-2788. doi.org/10.1002/ijc.33475.

Espinet, E., Z. Gu, C. D. Imbusch, N. A. Giese, M. Büscher, M. Safavi, S. Weisenburger, C. Klein, V. Vogel, M. Falcone, J. Insua-Rodríguez, M. Reitberger, V. Thiel, S. O. Kossi, A. Muckenhuber, K. Sarai, A. Y. L. Lee, E. Backx, S. Zarei, M. M. Gaida, M. Rodríguez-Paredes, E. Donato, H.-Y. Yen, R. Eils, M. Schlesner, N. Pfarr, T. Hackert, C. Plass, B. Brors, K. Steiger, D. Weichenhan, H. E. Arda, I. Rooman, J. L. Kopp, O. Strobel, W. Weichert, M. R. Sprick, and A. Trumpp (2021). "Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin." Cancer Discov. 11(3): 638–659. doi.org/10.1158/2159-8290.CD-20-1202.

Peduzzi, G., M. Gentiluomo, F. Tavano, P. G. Arcidiacono, S. Ermini, P. Vodicka, U. Boggi, G. M. Cavestro, G. Capurso, L. Morelli, A. C. Milanetto, R. Pezzilli, R. T. Lawlor, S. Carrara, M. Lovecek, P. Souček, F. Guo, T. Hackert, F. G. Uzunoğlu, M. Gazouli, A. Párniczky, J. Kupcinskas, M. F. Bijlsma, B. Bueno-de-Mesquita, R. Vermeulen, C. H. J. van Eijck, K. Jamroziak, R. Talar-Wojnarowska, W. Greenhalf, D. Gioffreda, M. C. Petrone, S. Landi, L. Archibugi, M. Puzzono, N. Funel, C. Sperti, M. L. Piredda, B. Mohelnikova-Duchonova, Y. Lu, V. Hlaváč, X. Gao, M. Schneider, J. R. Izbicki, G. Theodoropoulos, S. Bunduc, E. Kreivenaite, O. R. Busch, E. Małecka-Panas, E. Costello, F. Perri, S. G. G. Testoni, G. Vanella, C. Pasquali, M. Oliverius, H. Brenner, M. Loos, M. Götz, K. Georgiou, B. Erőss, E. Maiello, A. Szentesi, F. Bazzocchi, D. Basso, J. P. Neoptolemos, P. Hegyi, V. Kiudelis, F. Canzian, and D. Campa (2021). "Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk." Cancer Epidemiol Biomarkers Prev 30(12): 2342–2345. doi.org/10.1158/1055-9965.EPI-21-0353.

Tu, M., L. Klein, E. Espinet, T. Georgomanolis, F. Wegwitz, X. Li, L. Urbach, A. Danieli-Mackay, S. Küffer, K. Bojarczuk, A. Mizi, U. Günesdogan, B. Chapuy, Z. Gu, A. Neesse, U. Kishore, P. Ströbel, E. Hessmann, S. A. Hahn, A. Trumpp, A. Papantonis, V. Ellenrieder, and S. K. Singh (2021). "TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer." Nat Cancer 2: 1185–1203. doi.org/10.1038/s43018-021-00258-w.

Antwi, E. B., A. Olins, V. B. Teif, M. Bieg, T. Bauer, Z. Gu, B. Brors, R. Eils, D. Olins, and N. Ishaque (2020). "Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4." Biol. Open 9(2). www.ncbi.nlm.nih.gov/pubmed/31988093.

Ghassem-Zadeh, S., K. Hufnagel, A. Bauer, J.-L. Frossard, M. Yoshida, H. Kutsumi, H. Acha-Orbea, M. Neulinger-Munoz, J. Vey, C. Eckert, O. Strobel, J. D. Hoheisel, and K. Felix (2020). "Novel Autoantibody Signatures in Sera of Patients with Pancreatic Cancer, Chronic Pancreatitis and Autoimmune Pancreatitis: A Protein Microarray Profiling Approach." Int J Mol Sci 21(7). doi.org/10.3390/ijms21072403.

Hirth, M., J. Gandla, C. Hoeper, M. M. Gaida, N. Agarwal, M. Simonetti, A. Demir, Y. Xie, C. Weiss, C. W. Michalski, and R. Kuner (2020). "CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients." GASTROENTEROLOGY 159(2): 665–+. doi.org/10.1053/j.gastro.2020.04.037.

Manoochehri, M., Y. Wu, N. A. Giese, O. Strobel, S. Kutschmann, F. Haller, J. D. Hoheisel, E. A. Moskalev, T. Hackert, and A. S. Bauer (2020). "SST gene hypermethylation acts as a pan-cancer marker for pancreatic ductal adenocarcinoma and multiple other tumors: toward its use for blood-based diagnosis." Mol Oncol. doi.org/10.1002/1878-0261.12684EarlyAccess:APR2020DocumentType:Article;EarlyAccess.

Poschke, I. C., J. C. Hassel, A. Rodriguez-Ehrenfried, K. A. M. Lindner, I. Heras-Murillo, L. M. Appel, J. Lehmann, T. Lovgren, S. L. Wickstrom, C. Lauenstein, J. Roth, A.-K. Koenig, J. B. A. G. Haanen, J. van den Berg, R. Kiessling, F. Bergmann, M. Flossdorf, O. Strobel, and R. Offringa (2020). "The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones." CLINICAL CANCER RESEARCH 26(16): 4289–4301. doi.org/10.1158/1078-0432.CCR-19-3845.

Xia, L., Z. Xu, X. Zhou, F. Bergmann, N. Grabe, M. W. Büchler, J. P. Neoptolemos, T. Hackert, G. Kroemer, and F. Fortunato (2020). "Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis." Cell Death Dis 11(889): 1–15. doi.org/10.1038/s41419-020-03050-3.

Xu, X., K. Honda, N. Miura, S. Hori, S. Le Blanc, F. Bergmann, M. M. Gaida, M. Volkmar, S. Schimmack, T. Hackert, O. Strobel, and K. Felix (2020). "Actinin-4 splice variant - a complementary diagnostic and prognostic marker of pancreatic neuroendocrine neoplasms." J. Cancer 11(8): 2318–2328. doi.org/10.7150/jca.37503.

Bauer, A.S., Nazarov, P.V., Giese, N.A., Beghelli, S., Heller, A., Greenhalf, W., Costello, E., Muller, A., Bier, M., Strobel, O., Hackert, T., Vallar, L., Scarpa, A., Büchler, M.W., Neoptolemos, J.P., Kreis, S., Hoheisel, J.D., 2018. Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer. Int. J. Cancer 142, 1010–1021. doi.org/10.1002/ijc.31087

Felix, K., Hinz, U., Dobiasch, S., Hackert, T., Bergmann, F., Neumüller, M., Gronowitz, S., Bergqvist, M., Strobel, O., 2018. Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer. Pancreas 47, 72–79. doi.org/10.1097/MPA.0000000000000966

Heining, C., Horak, P., Uhrig, S., Codo, P.L., Klink, B., Hutter, B., Fröhlich, M., Bonekamp, D., Richter, D., Steiger, K., Penzel, R., Endris, V., Ehrenberg, K.R., Frank, S., Kleinheinz, K., Toprak, U.H., Schlesner, M., Mandal, R., Schulz, L., Lambertz, H., Fetscher, S., Bitzer, M., Malek, N.P., Horger, M.S., Giese, N.A., Strobel, O., Hackert, T., Springfeld, C., Feuerbach, L., Bergmann, F., Schröck, E., von Kalle, C., Weichert, W., Scholl, C., Ball, C.R., Stenzinger, A., Brors, B., Fröhling, S., Glimm, H., 2018. NRG1 Fusions in KRAS Wild-type Pancreatic Cancer. Cancer Discov. doi.org/10.1158/2159-8290.CD-18-0036

Jahreis, S., Trump, S., Bauer, M., Bauer, T., Thürmann, L., Feltens, R., Wang, Q., Gu, L., Grützmann, K., Röder, S., Averbeck, M., Weichenhan, D., Plass, C., Sack, U., Borte, M., Dubourg, V., Schüürmann, G., Simon, J.C., von Bergen, M., Hackermüller, J., Eils, R., Lehmann, I., Polte, T., 2018. Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications. J. Allergy Clin. Immunol. 141, 741–753. doi.org/10.1016/j.jaci.2017.03.017

Junge, K.M., Leppert, B., Jahreis, S., Wissenbach, D.K., Feltens, R., Grützmann, K., Thürmann, L., Bauer, T., Ishaque, N., Schick, M., Bewerunge-Hudler, M., Röder, S., Bauer, M., Schulz, A., Borte, M., Landgraf, K., Körner, A., Kiess, W., von Bergen, M., Stangl, G.I., Trump, S., Eils, R., Polte, T., Lehmann, I., 2018. MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development. Clin Epigenetics 10, 58. doi.org/10.1186/s13148-018-0478-z

Maier, L.J., Kallenberger, S.M., Jechow, K., Waschow, M., Eils, R., Conrad, C., 2018. Unraveling mitotic protein networks by 3D multiplexed epitope drug screening. Mol. Syst. Biol. 14, e8238.

Muckenhuber, A., Berger, A.K., Schlitter, A.M., Steiger, K., Konukiewitz, B., Trumpp, A., Eils, R., Werner, J., Friess, H., Esposito, I., Klöppel, G., Ceyhan, G.O., Jesinghaus, M., Denkert, C., Bahra, M., Stenzinger, A., Sprick, M.R., Jäger, D., Springfeld, C., Weichert, W., 2018. Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response. Clin. Cancer Res. 24, 351–359. doi.org/10.1158/1078-0432.CCR-17-2180

Reichert, M., Bakir, B., Moreira, L., Pitarresi, J.R., Feldmann, K., Simon, L., Suzuki, K., Maddipati, R., Rhim, A.D., Schlitter, A.M., Kriegsmann, M., Weichert, W., Wirth, M., Schuck, K., Schneider, G., Saur, D., Reynolds, A.B., Klein-Szanto, A.J., Pehlivanoglu, B., Memis, B., Adsay, N.V., Rustgi, A.K., 2018. Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev. Cell 45, 696-711.e8. doi.org/10.1016/j.devcel.2018.05.025

Schlereth, K., Weichenhan, D., Bauer, T., Heumann, T., Giannakouri, E., Lipka, D., Jaeger, S., Schlesner, M., Aloy, P., Eils, R., Plass, C., Augustin, H.G., 2018. The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife 7. doi.org/10.7554/eLife.34423

Gress, T. M., Lausser, L., Schirra, L.-R., Ortmüller, L., Diels, R., Kong, B., Michalski, C. W., Hackert, T., Strobel, O., Giese, N. A., Schenk, M., Lawlor, R. T., Scarpa, A., Kestler, H. A. and Buchholz, M. (2017). "Combined microRNA and mRNA microfluidic TaqMan array cards for the diagnosis of malignancy of multiple types of pancreatico-biliary tumors in fine-needle aspiration material." Oncotarget 8(64): 108223-108237. www.ncbi.nlm.nih.gov/pmc/articles/PMC5746138/.

Jabs, J., Zickgraf, F. M., Park, J., Wagner, S., Jiang, X., Jechow, K., Kleinheinz, K., Toprak, U. H., Schneider, M. A., Meister, M., Spaich, S., Sütterlin, M., Schlesner, M., Trumpp, A., Sprick, M., Eils, R. and Conrad, C. (2017). "Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations." Molecular Systems Biology 13(11): 955. www.ncbi.nlm.nih.gov/pubmed/29180611.

Kaistha, B. P., Krattenmacher, A., Fredebohm, J., Schmidt, H., Behrens, D., Widder, M., Hackert, T., Strobel, O., Hoheisel, J. D., Gress, T. M., Buchholz, M., Kaistha, B. P., Krattenmacher, A., Fredebohm, J., Schmidt, H., Behrens, D., Widder, M., Hackert, T., Strobel, O., Hoheisel, J. D., Gress, T. M. and Buchholz, M. (2017). "The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators." Oncotarget 8(39): 66215-66225. www.ncbi.nlm.nih.gov/pubmed/29029505

Kuhlmann, L., Nadler, W. M., Kerner, A., Hanke, S. A., Noll, E. M., Eisen, C., Espinet, E., Vogel, V., Trumpp, A., Sprick, M. R. and Roesli, C. P. (2017). "Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma." Pancreas 46(3): 311-322. www.ncbi.nlm.nih.gov/pubmed/27846146.

Reisinger, E., Genthner, L., Kerssemakers, J., Kensche, P., Borufka, S., Jugold, A., Kling, A., Prinz, M., Scholz, I., Zipprich, G., Eils, R., Lawerenz, C. and Eils, J. (2017). "OTP: An automatized system for managing and processing NGS data." Journal of Biotechnology. www.ncbi.nlm.nih.gov/pubmed/28803971.

Schlitter, A. M., Jesinghaus, M., Jäger, C., Konukiewitz, B., Muckenhuber, A., Demir, I. E., Bahra, M., Denkert, C., Friess, H., Kloeppel, G., Ceyhan, G. O. and Weichert, W. (2017). "pT but not pN stage of the 8th TNM classification significantly improves prognostication in pancreatic ductal adenocarcinoma." Eur. J. Cancer 84: 121–129. www.ncbi.nlm.nih.gov/pubmed/28802189.

Senís, E., Mockenhaupt, S., Rupp, D., Bauer, T., Paramasivam, N., Knapp, B., Gronych, J., Grosse, S., Windisch, M. P., Schmidt, F., Theis, F. J., Eils, R., Lichter, P., Schlesner, M., Bartenschlager, R. and Grimm, D. (2017). "TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus." Nucleic Acids Research 45(1): e3. www.ncbi.nlm.nih.gov/pubmed/27614072.

Bauer, T., Trump, S., Ishaque, N., Thürmann, L., Gu, L., Bauer, M., Bieg, M., Gu, Z., Weichenhan, D., Mallm, J.-P., Röder, S., Herberth, G., Takada, E., Mücke, O., Winter, M., Junge, K.M., Grützmann, K., Rolle-Kampczyk, U., Wang, Q., Lawerenz, C., Borte, M., Polte, T., Schlesner, M., Schanne, M., Wiemann, S., Geörg, C., Stunnenberg, H.G., Plass, C., Rippe, K., Mizuguchi, J., Herrmann, C., Eils, R., Lehmann, I., 2016. Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol. Syst. Biol. 12, 861. doi.org/10.15252/msb.20156520

Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel, V., Klaus, B., Nadler, W., Rösli, C., Lutz, C., Kulke, M., Engelhardt, J., Zickgraf, F.M., Espinosa, O., Schlesner, M., Jiang, X., Kopp-Schneider, A., Neuhaus, P., Bahra, M., Sinn, B.V., Eils, R., Giese, N.A., Hackert, T., Strobel, O., Werner, J., Büchler, M.W., Weichert, W., Trumpp, A., Sprick, M.R., 2016. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nat. Med. 22, 278–287. doi.org/10.1038/nm.4038

Poschke, I., Faryna, M., Bergmann, F., Flossdorf, M., Lauenstein, C., Hermes, J., Hinz, U., Hank, T., Ehrenberg, R., Volkmar, M., Loewer, M., Glimm, H., Hackert, T., Sprick, M.R., Höfer, T., Trumpp, A., Halama, N., Hassel, J.C., Strobel, O., Büchler, M., Sahin, U., Offringa, R., 2016. Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma. OncoImmunology 5, e1240859. doi.org/10.1080/2162402X.2016.1240859