Fassoni, A.C., Baldow, C., Roeder, I., Glauche, I., 2018. Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: A simulation study based on phase 3 trial data. Haematologica. doi.org/10.3324/haematol.2018.194522

Glauche, I., Kuhn, M., Baldow, C., Schulze, P., Rothe, T., Liebscher, H., Roy, A., Wang, X., Roeder, I., 2018. Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison. Sci Rep 8, 12330. doi.org/10.1038/s41598-018-29923-4

Gunes, C., Avila, A.I., Rudolph, K.L., 2018. Telomeres in cancer. Differentiation 99, 41–50. doi.org/10.1016/j.diff.2017.12.004

Schirm, S., Engel, C., Loibl, S., Loeffler, M., Scholz, M., 2018. Model-based optimization of G-CSF treatment during cytotoxic chemotherapy. J. Cancer Res. Clin. Oncol. 144, 343–358. doi.org/10.1007/s00432-017-2540-1

Stasik, S., Schuster, C., Ortlepp, C., Platzbecker, U., Bornhäuser, M., Schetelig, J., Ehninger, G., Folprecht, G., Thiede, C., 2018. An optimized targeted Next-Generation Sequencing approach for sensitive detection of single nucleotide variants. Biomol Detect Quantif 15, 6–12. doi.org/10.1016/j.bdq.2017.12.001

Suttorp, M., Schulze, P., Glauche, I., Göhring, G., von Neuhoff, N., Metzler, M., Sedlacek, P., de Bont, E.S.J.M., Balduzzi, A., Lausen, B., Aleinikova, O., Sufliarska, S., Henze, G., Strauss, G., Eggert, A., Kremens, B., Groll, A.H., Berthold, F., Klein, C., Groß-Wieltsch, U., Sykora, K.W., Borkhardt, A., Kulozik, A.E., Schrappe, M., Nowasz, C., Krumbholz, M., Tauer, J.T., Claviez, A., Harbott, J., Kreipe, H.H., Schlegelberger, B., Thiede, C., 2018. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Leukemia. https://doi.org/10.1038/s41375-018-0179-9


Baldow, C., Salentin, S., Schroeder, M., Roeder, I., Glauche, I., 2017. MAGPIE: Simplifying access and execution of computational models in the life sciences. PLoS Comput. Biol. 13, e1005898. doi.org/10.1371/journal.pcbi.1005898

Herold, S., Kuhn, M., Bonin, M.V., Stange, T., Platzbecker, U., Radke, J., Lange, T., Sockel, K., Gutsche, K., Schetelig, J., Röllig, C., Schuster, C., Roeder, I., Dahl, A., Mohr, B., Serve, H., Brandts, C., Ehninger, G., Bornhäuser, M., Thiede, C., 2017a. Donor cell leukemia-Evidence for multiple pre-leukemic clones and parallel long term clonal evolution in donor and recipient. Leukemia. doi.org/10.1038/leu.2017.104

Herold, S., Sockel, K., Sayehli, C., Herbst, R., Dührsen, U., Oelschlägel, U., Böttner, A., Hindahl, H., Kullmer, J., Helas, S., Sauer, M., Mohr, B., Mies, A., Bornhäuser, M., Ehninger, G., Röllig, C., Thiede, C., Platzbecker, U., 2017b. Evolution of NPM1-negative therapy-related myelodysplastic syndromes following curative treatment of NPM1-mutant AML. Leukemia 31, 2247–2251. doi.org/10.1038/leu.2017.217

Proschmann, R., Baldow, C., Rothe, T., Suttorp, M., Thiede, C., Tauer, J.T., Müller, M.C., Hochhaus, A., Roeder, I., Glauche, I., 2017. Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy. Haematologica 102, e39–e42. doi.org/10.3324/haematol.2016.154138

Zerjatke, T., Gak, I.A., Kirova, D., Fuhrmann, M., Daniel, K., Gonciarz, M., Mueller, D., Glauche, I., Mansfeld, J., 2017. Quantitative Cell Cycle Analysis Based on an Endogenous All-in-One Reporter for Cell Tracking and Classification. Cell Reports 19, 1953–1966. doi.org/10.1016/j.celrep.2017.05.022



Kuhn, M., Stange, T., Herold, S., Thiede, C., Roeder, I., 2016. Finding small somatic structural variants in exome sequencing data: a machine learning approach. Comput Stat 1–14. doi.org/10.1007/s00180-016-0674-2

Schoedel, K.B., Morcos, M.N.F., Zerjatke, T., Roeder, I., Grinenko, T., Voehringer, D., Göthert, J.R., Waskow, C., Roers, A., Gerbaulet, A., 2016. The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood. doi.org/10.1182/blood-2016-03-706010

Wang, J., Morita, Y., Han, B., Niemann, S., Löffler, B., Rudolph, K.L., 2016. Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Nat. Cell Biol. 18, 480–490. doi.org/10.1038/ncb3342


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