MitoPD

Publikationen

2020

Garrett, L., Chang, Y. J., Niedermeier, K. M., Heermann, T., Enard, W., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., Huttner, W. B., Wurst, W. and Hölter, S. M. (2020). "A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons." Transl Psychiatry 10(1): 1--14. www.nature.com/articles/s41398-020-0686-0.

2019

Blauwendraat, C., Heilbron, K., Vallerga, C. L., Bandres-Ciga, S., von Coelln, R., Pihlstrom, L., Simon-Sanchez, J., Schulte, C., Sharma, M., Krohn, L., Siitonen, A., Iwaki, H., Leonard, H., Noyce, A. J., Tan, M., Gibbs, J. R., Hernandez, D. G., Scholz, S. W., Jankovic, J., Shulman, L. M., Lesage, S., Corvol, J. C., Brice, A., van Hilten, J. J., Marinus, J., andMe Research, T., Eerola-Rautio, J., Tienari, P., Majamaa, K., Toft, M., Grosset, D. G., Gasser, T., Heutink, P., Shulman, J. M., Wood, N., Hardy, J., Morris, H. R., Hinds, D. A., Gratten, J., Visscher, P. M., Gan-Or, Z., Nalls, M. A., Singleton, A. B. and International Parkinson's Disease Genomics, C. (2019). "Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and alpha-synuclein mechanisms." Mov Disord 34(6): 866-875. www.ncbi.nlm.nih.gov/pubmed/30957308.

Fecher, C., Trovo, L., Muller, S. A., Snaidero, N., Wettmarshausen, J., Heink, S., Ortiz, O., Wagner, I., Kuhn, R., Hartmann, J., Karl, R. M., Konnerth, A., Korn, T., Wurst, W., Merkler, D., Lichtenthaler, S. F., Perocchi, F. and Misgeld, T. (2019). "Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity." Nat Neurosci 22(10): 1731-1742. www.ncbi.nlm.nih.gov/pubmed/31501572.

Glaab, E., Trezzi, J. P., Greuel, A., Jager, C., Hodak, Z., Drzezga, A., Timmermann, L., Tittgemeyer, M., Diederich, N. J. and Eggers, C. (2019). "Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease." Neurobiol Dis 124: 555-562. www.ncbi.nlm.nih.gov/pubmed/30639291.

Grossmann, D., Berenguer-Escuder, C., Bellet, M. E., Scheibner, D., Bohler, J., Massart, F., Rapaport, D., Skupin, A., Fouquier d'Herouel, A., Sharma, M., Ghelfi, J., Rakovic, A., Lichtner, P., Antony, P., Glaab, E., May, P., Dimmer, K. S., Fitzgerald, J. C., Gruenewald, A. and Kruger, R. (2019). "Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease." Antioxid Redox Signal. www.ncbi.nlm.nih.gov/pubmed/31303019.

Heermann, T., Garrett, L., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Graw, J. and Hölter, S. M. (2019). "Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice." Molecular Neurobiology 56(6): 4215-4230. www.ncbi.nlm.nih.gov/pubmed/30291584.

Hollerhage, M., Fussi, N., Rosler, T. W., Wurst, W., Behrends, C. and Hoglinger, G. U. (2019). "Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons." Neuropharmacology 149: 13-26. www.ncbi.nlm.nih.gov/pubmed/30731136.

van Well, E. M., Bader, V., Patra, M., Sanchez-Vicente, A., Meschede, J., Furthmann, N., Schnack, C., Blusch, A., Longworth, J., Petrasch-Parwez, E., Mori, K., Arzberger, T., Trumbach, D., Angersbach, L., Showkat, C., Sehr, D. A., Berlemann, L. A., Goldmann, P., Clement, A. M., Behl, C., Woerner, A. C., Saft, C., Wurst, W., Haass, C., Ellrichmann, G., Gold, R., Dittmar, G., Hipp, M. S., Hartl, F. U., Tatzelt, J. and Winklhofer, K. F. (2019). "A protein quality control pathway regulated by linear ubiquitination." EMBO J 38(9). www.ncbi.nlm.nih.gov/pubmed/30886048.

2018

Fussi, N., Höllerhage, M., Chakroun, T., Nykänen, N.-P., Rösler, T. W., Koeglsperger, T., Wurst, W., Behrends, C. and Höglinger, G. U. (2018). "Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy." Cell Death & Disease 9(7): 757. www.ncbi.nlm.nih.gov/pubmed/29988147.

Garrett, L., Becker, L., Rozman, J., Puk, O., Stoeger, T., Yildirim, A. Ö., Bohla, A., Eickelberg, O., Hans, W., Prehn, C., Adamski, J., Klopstock, T., Rácz, I., Zimmer, A., Klingenspor, M., Fuchs, H., Gailus-Durner, V., Wurst, W., Hrabě de Angelis, M., Graw, J. and Hölter, S. M. (2018). "Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice." Molecular Neurobiology 55(6): 4580-4595. www.ncbi.nlm.nih.gov/pubmed/28695538.

Glaab, E. (2018). "Computational systems biology approaches for Parkinson's disease." Cell and Tissue Research 373(1): 91-109. www.ncbi.nlm.nih.gov/pubmed/29185073.

Jung, P. P., Zhang, Z., Paczia, N., Jaeger, C., Ignac, T., May, P. and Linster, C. L. (2018). "Natural variation of chronological aging in theSaccharomyces cerevisiaespecies reveals diet-dependent mechanisms of life span control." NPJ aging and mechanisms of disease 4: 3. www.ncbi.nlm.nih.gov/pubmed/29560271.

Rotermund, C., Machetanz, G. and Fitzgerald, J. C. (2018). "The Therapeutic Potential of Metformin in Neurodegenerative Diseases." Frontiers in Endocrinology 9. www.frontiersin.org/articles/10.3389/fendo.2018.00400/full.

Zimprich, A., Östereicher, M. A., Becker, L., Dirscherl, P., Ernst, L., Fuchs, H., Gailus-Durner, V., Garrett, L., Giesert, F., Glasl, L., Hummel, A., Rozman, J., de Angelis, M. H., Vogt-Weisenhorn, D., Wurst, W. and Hölter, S. M. (2018). "Analysis of locomotor behavior in the German Mouse Clinic." Journal of Neuroscience Methods 300: 77-91. www.ncbi.nlm.nih.gov/pubmed/28483715.

2017

Ashrafi, A., Garcia, P., Kollmus, H., Schughart, K., Del Sol, A., Buttini, M., Glaab, E., 2017. Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson’s disease. Neurobiol. Aging 58, 30–33. doi.org/10.1016/j.neurobiolaging.2017.06.008

Garrett, L., Becker, L., Rozman, J., Puk, O., Stoeger, T., Yildirim, A.Ö., Bohla, A., Eickelberg, O., Hans, W., Prehn, C., Adamski, J., Klopstock, T., Rácz, I., Zimmer, A., Klingenspor, M., Fuchs, H., Gailus-Durner, V., Wurst, W., Hrabě de Angelis, M., Graw, J., Hölter, S.M., 2017. Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice. Mol. Neurobiol. doi.org/10.1007/s12035-017-0659-3

Giesert, F., Glasl, L., Zimprich, A., Ernst, L., Piccoli, G., Stautner, C., Zerle, J., Hölter, S.M., Vogt Weisenhorn, D.M., Wurst, W., 2017. The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson’s disease in the mouse. Neurobiol. Dis. 105, 179–193. doi.org/10.1016/j.nbd.2017.05.013

Jansen, I.E., Gibbs, J.R., Nalls, M.A., Price, T.R., Lubbe, S., van Rooij, J., Uitterlinden, A.G., Kraaij, R., Williams, N.M., Brice, A., Hardy, J., Wood, N.W., Morris, H.R., Gasser, T., Singleton, A.B., Heutink, P., Sharma, M., 2017a. Establishing the role of rare coding variants in known Parkinson’s disease risk loci. Neurobiology of Aging. doi.org/10.1016/j.neurobiolaging.2017.07.009

Jansen, I.E., Ye, H., Heetveld, S., Lechler, M.C., Michels, H., Seinstra, R.I., Lubbe, S.J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J.R., Nalls, M.A., Ryten, M., Botia, J.A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., Chouhan, A.K., Li, Y., Yogi, P., Amin, N., van Duijn, C.M., International Parkinson’s Disease Genetics Consortium (IPGDC), Morris, H.R., Brice, A., Singleton, A.B., David, D.C., Nollen, E.A., Jain, S., Shulman, J.M., Heutink, P., 2017b. Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing. Genome Biol. 18, 22. doi.org/10.1186/s13059-017-1147-9

Pfeuffer, J., Sachsenberg, T., Alka, O., Walzer, M., Fillbrunn, A., Nilse, L., Schilling, O., Reinert, K., Kohlbacher, O., 2017. OpenMS - A platform for reproducible analysis of mass spectrometry data. J. Biotechnol. 261, 142–148. doi.org/10.1016/j.jbiotec.2017.05.016

Salminen, A.V., Garrett, L., Schormair, B., Rozman, J., Giesert, F., Niedermeier, K.M., Becker, L., Rathkolb, B., Rácz, I., German Mouse Clinic Consortium, Klingenspor, M., Klopstock, T., Wolf, E., Zimmer, A., Gailus-Durner, V., Torres, M., Fuchs, H., Hrabě de Angelis, M., Wurst, W., Hölter, S.M., Winkelmann, J., 2017. Meis1: effects on motor phenotypes and the sensorimotor system in mice. Dis Model Mech 10, 981–991. doi.org/10.1242/dmm.030080

Zanon, A., Kalvakuri, S., Rakovic, A., Foco, L., Guida, M., Schwienbacher, C., Serafin, A., Rudolph, F., Trilck, M., Gruenewald, A., Stanslowsky, N., Wegner, F., Giorgio, V., Lavdas, A.A., Bodmer, R., Pramstaller, P.P., Klein, C., Hicks, A.A., Pichler, I., Seibler, P., 2017. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum. Mol. Genet. 26, 2412–2425. doi.org/10.1093/hmg/ddx132

 

2016

Vogt Weisenhorn, D.M., Giesert, F., Wurst, W., 2016. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson’s Disease. J. Neurochem. 139 Suppl 1, 8–26. doi.org/10.1111/jnc.13670

Wüst, R., Maurer, B., Hauser, K., Woitalla, D., Sharma, M., Krüger, R., 2016. Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson’s disease. Neurobiol. Aging 39, 217.e13-15. doi.org/10.1016/j.neurobiolaging.2015.11.025

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