CancerTelSys

Publikationen

2018

Ansari, S.S., Sharma, A.K., Soni, H., Ali, D.M., Tews, B., König, R., Eibl, H., Berger, M.R., 2018. Induction of ER and mitochondrial stress by the alkylphosphocholine erufosine in oral squamous cell carcinoma cells. Cell Death Dis 9, 296. doi.org/10.1038/s41419-018-0342-2

Bonetti, D., Longhese, M.P., 2018. Analysis of De Novo Telomere Addition by Southern Blot. Methods Mol. Biol. 1672, 363–373. doi.org/10.1007/978-1-4939-7306-4_25

Braun, D.M., Chung, I., Kepper, N., Deeg, K.I., Rippe, K., 2018. TelNet - a database for human and yeast genes involved in telomere maintenance. BMC Genet. 19, 32. https://doi.org/10.1186/s12863-018-0617-8

Chudasama, P., Mughal, S.S., Sanders, M.A., Hübschmann, D., Chung, I., Deeg, K.I., Wong, S.-H., Rabe, S., Hlevnjak, M., Zapatka, M., Ernst, A., Kleinheinz, K., Schlesner, M., Sieverling, L., Klink, B., Schröck, E., Hoogenboezem, R.M., Kasper, B., Heilig, C.E., Egerer, G., Wolf, S., von Kalle, C., Eils, R., Stenzinger, A., Weichert, W., Glimm, H., Gröschel, S., Kopp, H.-G., Omlor, G., Lehner, B., Bauer, S., Schimmack, S., Ulrich, A., Mechtersheimer, G., Rippe, K., Brors, B., Hutter, B., Renner, M., Hohenberger, P., Scholl, C., Fröhling, S., 2018. Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun 9, 144. doi.org/10.1038/s41467-017-02602-0

Kluth, M., Scherzai, S., Büschek, F., Fraune, C., Möller, K., Höflmayer, D., Minner, S., Göbel, C., Möller-Koop, C., Hinsch, A., Neubauer, E., Tsourlakis, M.C., Sauter, G., Heinzer, H., Graefen, M., Wilczak, W., Luebke, A.M., Burandt, E., Steurer, S., Schlomm, T., Simon, R., 2018. 13q deletion is linked to an adverse phenotype and poor prognosis in prostate cancer. Genes Chromosomes Cancer 57, 504–512. https://doi.org/10.1002/gcc.22645

Luke, B., 2018. Telomere regulation. Differentiation 102, 27–29. https://doi.org/10.1016/j.diff.2018.06.002

Michelini, F., Jalihal, A.P., Francia, S., Meers, C., Neeb, Z.T., Rossiello, F., Gioia, U., Aguado, J., Jones-Weinert, C., Luke, B., Biamonti, G., Nowacki, M., Storici, F., Carninci, P., Walter, N.G., Fagagna, F. d’Adda di, 2018. From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond. Chem. Rev. 118, 4365–4403. doi.org/10.1021/acs.chemrev.7b00487

Misino, S., Bonetti, D., Luke-Glaser, S., Luke, B., 2018. Increased TERRA levels and RNase H sensitivity are conserved hallmarks of post-senescent survivors in budding yeast. Differentiation 100, 37–45. doi.org/10.1016/j.diff.2018.02.002

Sorokin, D.V., Peterlik, I., Tektonidis, M., Rohr, K., Matula, P., 2018. Non-Rigid Contour-Based Registration of Cell Nuclei in 2-D Live Cell Microscopy Images Using a Dynamic Elasticity Model. IEEE Trans Med Imaging 37, 173–184. doi.org/10.1109/TMI.2017.2734169

2017

Braun, D.M., Chung, I., Kepper, N., Rippe, K., 2017. TelNet - a database for human and yeast genes involved in telomere maintenance. bioRxiv 130153. doi.org/10.1101/130153

Graf, M., Bonetti, D., Lockhart, A., Serhal, K., Kellner, V., Maicher, A., Jolivet, P., Teixeira, M.T., Luke, B., 2017. Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle. Cell 170, 72–85.e14. doi.org/10.1016/j.cell.2017.06.006

Gunkel, M., Chung, I., Wörz, S., Deeg, K.I., Simon, R., Sauter, G., Jones, D.T.W., Korshunov, A., Rohr, K., Erfle, H., Rippe, K., 2017a. Quantification of telomere features in tumor tissue sections by an automated 3D imaging-based workflow. Methods 114, 60–73. doi.org/10.1016/j.ymeth.2016.09.014

Gunkel, M., Eberle, J.P., Erfle, H., 2017b. Fluorescence-Based High-Throughput and Targeted Image Acquisition and Analysis for Phenotypic Screening. Methods Mol. Biol. 1563, 269–280. doi.org/10.1007/978-1-4939-6810-7_17

Kluth, M., Jung, S., Habib, O., Eshagzaiy, M., Heinl, A., Amschler, N., Masser, S., Mader, M., Runte, F., Barow, P., Frogh, S., Omari, J., Möller-Koop, C., Hube-Magg, C., Weischenfeldt, J., Korbel, J., Steurer, S., Krech, T., Huland, H., Graefen, M., Minner, S., Sauter, G., Schlomm, T., Simon, R., 2017. Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer. Oncotarget 8, 108923–108935. doi.org/10.18632/oncotarget.22408

Lafuente-Barquero, J., Luke-Glaser, S., Graf, M., Silva, S., Gómez-González, B., Lockhart, A., Lisby, M., Aguilera, A., Luke, B., 2017. The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. PLoS Genet. 13, e1007136. doi.org/10.1371/journal.pgen.1007136

Saraiva, J.P., Oswald, M., Biering, A., Röll, D., Assmann, C., Klassert, T., Blaess, M., Czakai, K., Claus, R., Löffler, J., Slevogt, H., König, R., 2017. Fungal biomarker discovery by integration of classifiers. BMC Genomics 18, 601. doi.org/10.1186/s12864-017-4006-x

Saraiva, L.F., P, J., Zubiria-Barrera, C., Klassert, T.E., Lautenbach, M.J., Blaess, M., Claus, R.A., Slevogt, H., König, R., 2017. Combination of Classifiers Identifies Fungal-Specific Activation of Lysosome Genes in Human Monocytes. Front. Microbiol. 8. doi.org/10.3389/fmicb.2017.02366

Tektonidis, M., Rohr, K., 2017. Diffeomorphic Multi-Frame Non-Rigid Registration of Cell Nuclei in 2D and 3D Live Cell Images. IEEE Trans Image Process 26, 1405–1417. doi.org/10.1109/TIP.2017.2653360

2016

Deeg, K.I., Chung, I., Bauer, C., Rippe, K., 2016. Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition. Front Oncol 6, 186. doi.org/10.3389/fonc.2016.00186

Dieckmann, A.K., Babin, V., Harari, Y., Eils, R., König, R., Luke, B., Kupiec, M., 2016. Role of the ESCRT Complexes in Telomere Biology. MBio 7. doi.org/10.1128/mBio.01793-16

Eck, S., Wörz, S., Müller-Ott, K., Hahn, M., Biesdorf, A., Schotta, G., Rippe, K., Rohr, K., 2016. A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci. Med Image Anal 32, 18–31. doi.org/10.1016/j.media.2016.03.001

Ernst, A., Jones, D.T.W., Maass, K.K., Rode, A., Deeg, K.I., Jebaraj, B.M.C., Korshunov, A., Hovestadt, V., Tainsky, M.A., Pajtler, K.W., Bender, S., Brabetz, S., Gröbner, S., Kool, M., Devens, F., Edelmann, J., Zhang, C., Castelo-Branco, P., Tabori, U., Malkin, D., Rippe, K., Stilgenbauer, S., Pfister, S.M., Zapatka, M., Lichter, P., 2016. Telomere dysfunction and chromothripsis. Int. J. Cancer 138, 2905–2914. doi.org/10.1002/ijc.30033

Gietzelt, M., Höfer, T., Knaup-Gregori, P., König, R., Löpprich, M., Poos, A., Ganzinger, M., 2016. The Use of Tools, Modelling Methods, Data Types, and Endpoints in Systems Medicine: A Survey on Projects of the German e:Med-Programme. Stud Health Technol Inform 228, 670–674. doi.org/10.3233/978-1-61499-678-1-670

International Cancer Genome Consortium PedBrain Tumor Project, 2016. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. Nat. Med. 22, 1314–1320. doi.org/10.1038/nm.4204

Kordaß, T., Weber, C.E.M., Oswald, M., Ast, V., Bernhardt, M., Novak, D., Utikal, J., Eichmüller, S.B., König, R., 2016. SOX5 is involved in balanced MITF regulation in human melanoma cells. BMC Med Genomics 9, 10. doi.org/10.1186/s12920-016-0170-0

Poos, A.M., Maicher, A., Dieckmann, A.K., Oswald, M., Eils, R., Kupiec, M., Luke, B., König, R., 2016. Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast. Nucleic Acids Res. doi.org/10.1093/nar/gkw111

Sharma, A.K., Eils, R., König, R., 2016. Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism. Cancer Res. 76, 4058–4067. http://doi.org/10.1158/0008-5472.CAN-15-2350

2015

Mallm, J.-P., Rippe, K., 2015. Aurora Kinase B Regulates Telomerase Activity via a Centromeric RNA in Stem Cells. Cell Rep 11, 1667–1678. doi.org/10.1016/j.celrep.2015.05.015

Melling, N., Thomsen, E., Tsourlakis, M.C., Kluth, M., Hube-Magg, C., Minner, S., Koop, C., Graefen, M., Heinzer, H., Wittmer, C., Sauter, G., Wilczak, W., Huland, H., Simon, R., Schlomm, T., Steurer, S., Krech, T., 2015. Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters. Carcinogenesis 36, 1333–1340. doi.org/10.1093/carcin/bgv137

Osterwald, S., Deeg, K.I., Chung, I., Parisotto, D., Wörz, S., Rohr, K., Erfle, H., Rippe, K., 2015. PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening. J. Cell. Sci. 128, 1887–1900. doi.org/10.1242/jcs.148296

Rippe, K., Luke, B., 2015. TERRA and the state of the telomere. Nat. Struct. Mol. Biol. 22, 853–858. http://doi.org/10.1038/nsmb.3078

2014

Schacht, T., Oswald, M., Eils, R., Eichmüller, S.B., König, R., 2014. Estimating the activity of transcription factors by the effect on their target genes. Bioinformatics 30, i401-407. doi.org/10.1093/bioinformatics/btu446