Multiscale HCC

Publikationen

2019

Griessinger, C. M., Schmid, A. M., Sonanini, D., Schorg, B. F., Jarboui, M. A., Bukala, D., Mucha, N., Fehrenbacher, B., Steinhilber, J., Martella, M., Kohlhofer, U., Schaller, M., Zender, L., Rammensee, H. G., Quintanilla-Martinez, L., Rocken, M., Kneilling, M.Pichler, B. J., 2019. The administration route of tumor-antigen-specific T-helper cells differentially modulates the tumor microenvironment and senescence. Carcinogenesis. doi.org/10.1093/carcin/bgy161

2018

Frey, N., Venturelli, S., Zender, L.Bitzer, M., 2018. Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics. Nat Rev Gastroenterol Hepatol, 15(2), 81-95. doi.org/10.1038/nrgastro.2017.146

Mohr, C., Friedrich, A., Wojnar, D., Kenar, E., Polatkan, A. C., Codrea, M. C., Czemmel, S., Kohlbacher, O.Nahnsen, S., 2018. qPortal: A platform for data-driven biomedical research. PLoS ONE, 13(1), e0191603. doi.org/10.1371/journal.pone.0191603

Seehawer, M., Heinzmann, F., D'Artista, L., Harbig, J., Roux, P.-F., Hoenicke, L., Dang, H., Klotz, S., Robinson, L., Doré, G., Rozenblum, N., Kang, T.-W., Chawla, R., Buch, T., Vucur, M., Roth, M., Zuber, J., Luedde, T., Sipos, B., Longerich, T., Heikenwälder, M., Wang, X. W., Bischof, O.Zender, L., 2018. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature. doi.org/10.1038/s41586-018-0519-y

Thaiss, W. M., Haberland, U., Kaufmann, S., Hepp, T., Schulze, M., Blum, A. C., Ketelsen, D., Nikolaou, K., Horger, M.Sauter, A. W., 2018. Dose Optimization of Perfusion-derived Response Assessment in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: Comparison of Volume Perfusion CT and Iodine Concentration. Academic Radiology. doi.org/10.1016/j.acra.2018.09.026

 

2017

Kurucay, M., Kloth, C., Kaufmann, S., Nikolaou, K., Bösmüller, H., Horger, M., Thaiss, W.M., 2017. Multiparametric imaging for detection and characterization of hepatocellular carcinoma using gadoxetic acid-enhanced MRI and perfusion-CT: which parameters work best? Cancer Imaging 17, 18. doi.org/10.1186/s40644-017-0121-9

Perfahl, H., Hughes, B.D., Alarcón, T., Maini, P.K., Lloyd, M.C., Reuss, M., Byrne, H.M., 2017. 3D hybrid modelling of vascular network formation. Journal of Theoretical Biology 414, 254–268. doi.org/10.1016/j.jtbi.2016.11.013

Schroeder, C.M., Hilke, F.J., Löffler, M.W., Bitzer, M., Lenz, F., Sturm, M., 2017. A comprehensive quality control workflow for paired tumor-normal NGS experiments. Bioinformatics 33, 1721–1722. doi.org/10.1093/bioinformatics/btx032

2016

Dauch, D., Rudalska, R., Cossa, G., Nault, J.-C., Kang, T.-W., Wuestefeld, T., Hohmeyer, A., Imbeaud, S., Yevsa, T., Hoenicke, L., Pantsar, T., Bozko, P., Malek, N.P., Longerich, T., Laufer, S., Poso, A., Zucman-Rossi, J., Eilers, M., Zender, L., 2016. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat. Med. 22, 744–753. doi.org/10.1038/nm.4107

Eggert, T., Wolter, K., Ji, J., Ma, C., Yevsa, T., Klotz, S., Medina-Echeverz, J., Longerich, T., Forgues, M., Reisinger, F., Heikenwalder, M., Wang, X.W., Zender, L., Greten, T.F., 2016. Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. Cancer Cell 30, 533–547. doi.org/10.1016/j.ccell.2016.09.003

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M.P., Matheson, N.J., Patten, D.A., Shetty, S., Parry, A.J., Menon, S., Salama, R., Antrobus, R., Tomimatsu, K., Howat, W., Lehner, P.J., Zender, L., Narita, M., 2016. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat. Cell Biol. 18, 979–992. doi.org/10.1038/ncb3397

Syha, R., Grözinger, G., Grosse, U., Maurer, M., Zender, L., Horger, M., Nikolaou, K., Ketelsen, D., 2016. Parenchymal Blood Volume Assessed by C-Arm-Based Computed Tomography in Immediate Posttreatment Evaluation of Drug-Eluting Bead Transarterial Chemoembolization in Hepatocellular Carcinoma. Invest Radiol 51, 121–126. doi.org/10.1097/RLI.0000000000000215

Thaiss, W.M., Kaufmann, S., Kloth, C., Nikolaou, K., Bösmüller, H., Horger, M., 2016. VEGFR-2 expression in HCC, dysplastic and regenerative liver nodules, and correlation with pre-biopsy Dynamic Contrast Enhanced CT. Eur J Radiol 85, 2036–2041. http://doi.org/10.1016/j.ejrad.2016.09.012

2015

Kaufmann, S., Horger, T., Oelker, A., Beck, S., Schulze, M., Nikolaou, K., Ketelsen, D., Horger, M., 2015a. Volume perfusion computed tomography (VPCT)-based evaluation of response to TACE using two different sized drug eluting beads in patients with nonresectable hepatocellular carcinoma: Impact on tumor and liver parenchymal vascularisation. Eur J Radiol 84, 2548–2554. doi.org/10.1016/j.ejrad.2015.09.009

Kaufmann, S., Horger, T., Oelker, A., Kloth, C., Nikolaou, K., Schulze, M., Horger, M., 2015b. Characterization of hepatocellular carcinoma (HCC) lesions using a novel CT-based volume perfusion (VPCT) technique. Eur J Radiol 84, 1029–1035. doi.org/10.1016/j.ejrad.2015.02.020

Schneeweiß, S., Horger, M., Ketelsen, D., Ioanoviciu, S.D., 2015. [Complications after TACE in HCC]. Rofo 36, 79–82. http://doi.org/10.1055/s-0034-1369532

2014

Dengel, B.-S., Perfahl, H., Galliani, S., Reuss, M., 2015. The VasCan Project: Simulation of Vascular Tumour Growth and Angiogenesis Using a Multiscale Model, in: High Performance Computing in Science and Engineering ‘14. Springer, Cham, pp. 683–691. http://doi.org/10.1007/978-3-319-10810-0_45

 

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