SysINFLAME

Publikationen

2018

Bauer, C., le Saux, O., Pomozi, V., Aherrahrou, R., Kriesen, R., Stölting, S., Liebers, A., Kessler, T., Schunkert, H., Erdmann, J., Aherrahrou, Z., 2018. Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation. Sci Rep 8, 5812. doi.org/10.1038/s41598-018-24228-y

Baurecht, H., Rühlemann, M.C., Rodríguez, E., Thielking, F., Harder, I., Erkens, A.-S., Stölzl, D., Ellinghaus, E., Hotze, M., Lieb, W., Wang, S., Heinsen-Groth, F.-A., Franke, A., Weidinger, S., 2018. Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration. J. Allergy Clin. Immunol. 141, 1668-1676.e16. doi.org/10.1016/j.jaci.2018.01.019

Béziat, V., Li, J., Lin, J.-X., Ma, C.S., Li, P., Bousfiha, A., Pellier, I., Zoghi, S., Baris, S., Keles, S., Gray, P., Du, N., Wang, Y., Zerbib, Y., Lévy, R., Leclercq, T., About, F., Lim, A.I., Rao, G., Payne, K., Pelham, S.J., Avery, D.T., Deenick, E.K., Pillay, B., Chou, J., Guery, R., Belkadi, A., Guérin, A., Migaud, M., Rattina, V., Ailal, F., Benhsaien, I., Bouaziz, M., Habib, T., Chaussabel, D., Marr, N., El-Benna, J., Grimbacher, B., Wargon, O., Bustamante, J., Boisson, B., Müller-Fleckenstein, I., Fleckenstein, B., Chandesris, M.-O., Titeux, M., Fraitag, S., Alyanakian, M.-A., Leruez-Ville, M., Picard, C., Meyts, I., Di Santo, J.P., Hovnanian, A., Somer, A., Ozen, A., Rezaei, N., Chatila, T.A., Abel, L., Leonard, W.J., Tangye, S.G., Puel, A., Casanova, J.-L., 2018. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol 3. doi.org/10.1126/sciimmunol.aat4956

Egg, D., Schwab, C., Gabrysch, A., Arkwright, P.D., Cheesman, E., Giulino-Roth, L., Neth, O., Snapper, S., Okada, S., Moutschen, M., Delvenne, P., Pecher, A.-C., Wolff, D., Kim, Y.-J., Seneviratne, S., Kim, K.-M., Kang, J.-M., Ojaimi, S., McLean, C., Warnatz, K., Seidl, M., Grimbacher, B., 2018. Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers. Front Immunol 9, 2012. doi.org/10.3389/fimmu.2018.02012

Fangmann, D., Theismann, E.-M., Türk, K., Schulte, D.M., Relling, I., Hartmann, K., Keppler, J.K., Knipp, J.-R., Rehman, A., Heinsen, F.-A., Franke, A., Lenk, L., Freitag-Wolf, S., Appel, E., Gorb, S., Brenner, C., Seegert, D., Waetzig, G.H., Rosenstiel, P., Schreiber, S., Schwarz, K., Laudes, M., 2018. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans. Diabetes Care 41, 398–405. doi.org/10.2337/dc17-1967

Fliegauf, M., Grimbacher, B., 2018. NFkB mutations in humans: The devil is in the details. J. Allergy Clin. Immunol. doi.org/10.1016/j.jaci.2018.06.050

Frey-Jakobs, S., Hartberger, J.M., Fliegauf, M., Bossen, C., Wehmeyer, M.L., Neubauer, J.C., Bulashevska, A., Proietti, M., Fröbel, P., Nöltner, C., Yang, L., Rojas-Restrepo, J., Langer, N., Winzer, S., Engelhardt, K.R., Glocker, C., Pfeifer, D., Klein, A., Schäffer, A.A., Lagovsky, I., Lachover-Roth, I., Béziat, V., Puel, A., Casanova, J.-L., Fleckenstein, B., Weidinger, S., Kilic, S.S., Garty, B.-Z., Etzioni, A., Grimbacher, B., 2018. ZNF341 controls STAT3 expression and thereby immunocompetence. Sci Immunol 3. doi.org/10.1126/sciimmunol.aat4941

Häsler, R., Kautz, C., Rehman, A., Podschun, R., Gassling, V., Brzoska, P., Sherlock, J., Gräsner, J.-T., Hoppenstedt, G., Schubert, S., Ferlinz, A., Lieb, W., Laudes, M., Heinsen, F.-A., Scholz, J., Harmsen, D., Franke, A., Eisend, S., Kunze, T., Fickenscher, H., Ott, S., Rosenstiel, P., Schreiber, S., 2018. The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany. Microbiome 6, 37. doi.org/10.1186/s40168-018-0414-7

Howell, K.J., Kraiczy, J., Nayak, K.M., Gasparetto, M., Ross, A., Lee, C., Mak, T.N., Koo, B.-K., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M., 2018. DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology 154, 585–598. doi.org/10.1053/j.gastro.2017.10.007

Jacobs, G., Wolf, A., Krawczak, M., Lieb, W., 2018. Biobanks in the Era of Digital Medicine. Clin. Pharmacol. Ther. 103, 761–762. doi.org/10.1002/cpt.968

Jung, S., Gamez-Diaz, L., Proietti, M., Grimbacher, B., 2018. “Immune TOR-opathies,” a Novel Disease Entity in Clinical Immunology. Front. Immunol. 9, 966. doi.org/10.3389/fimmu.2018.00966

Kachroo, P., Szymczak, S., Heinsen, F.-A., Forster, M., Bethune, J., Hemmrich-Stanisak, G., Baker, L., Schrappe, M., Stanulla, M., Franke, A., 2018. NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia. Epigenomics 10, 133–147. doi.org/10.2217/epi-2017-0080

Nikolaus, S., Waetzig, G.H., Butzin, S., Ziolkiewicz, M., Al-Massad, N., Thieme, F., Lövgren, U., Rasmussen, B.B., Reinheimer, T.M., Seegert, D., Rosenstiel, P., Szymczak, S., Schreiber, S., 2018. Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases. Int J Colorectal Dis. doi.org/10.1007/s00384-018-3069-8

Oliver, A.L.-S., Baumgart, S., Bremser, W., Flemig, S., Wittke, D., Gruetzkau, A., Luch, A., Haase, A., Jakubowski, N., 2018. Quantification of silver nanoparticles taken up by single cells using inductively coupled plasma mass spectrometry in the single cell measurement mode. J. Anal. At. Spectrom. 33, 1256–1263. doi.org/10.1039/c7ja00395a

Schubert, D., Klein, M.-C., Hassdenteufel, S., Caballero-Oteyza, A., Yang, L., Proietti, M., Bulashevska, A., Kemming, J., Kühn, J., Winzer, S., Rusch, S., Fliegauf, M., Schäffer, A.A., Pfeffer, S., Geiger, R., Cavalié, A., Cao, H., Yang, F., Li, Y., Rizzi, M., Eibel, H., Kobbe, R., Marks, A.L., Peppers, B.P., Hostoffer, R.W., Puck, J.M., Zimmermann, R., Grimbacher, B., 2018. Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1). J. Allergy Clin. Immunol. 141, 1427–1438. doi.org/10.1016/j.jaci.2017.06.042

Schulte-Wrede, U., Sörensen, T., Grün, J.R., Häupl, T., Hirseland, H., Steinbrich-Zöllner, M., Wu, P., Radbruch, A., Poddubnyy, D., Sieper, J., Syrbe, U., Grützkau, A., 2018. An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus. Arthritis Res. Ther. 20, 191. doi.org/10.1186/s13075-018-1692-y

Schultze, J.L., SYSCID consortium, Rosenstiel, P., 2018. Systems Medicine in Chronic Inflammatory Diseases. Immunity 48, 608–613. doi.org/10.1016/j.immuni.2018.03.022

Thingholm, L., Rühlemann, M., Wang, J., Hübenthal, M., Lieb, W., Laudes, M., Franke, A., D’Amato, M., 2018. Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. Gut. doi.org/10.1136/gutjnl-2017-315841

Worth, L., Michel, S., Gaertner, V.D., Kabesch, M., Schieck, M., 2018. Asthma- and IgE-associated polymorphisms affect expression of TH 17 genes. Allergy 73, 1342–1347. doi.org/10.1111/all.13422

Zeissig, S., Rosati, E., Dowds, C.M., Aden, K., Bethge, J., Schulte, B., Pan, W.H., Mishra, N., Zuhayra, M., Marx, M., Paulsen, M., Strigli, A., Conrad, C., Schuldt, D., Sinha, A., Ebsen, H., Kornell, S.-C., Nikolaus, S., Arlt, A., Kabelitz, D., Ellrichmann, M., Lützen, U., Rosenstiel, P.C., Franke, A., Schreiber, S., 2018. Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease. Gut. doi.org/10.1136/gutjnl-2018-316023

Zhu, C., Miller, M., Marpaka, S., Vaysberg, P., Rühlemann, M.C., Wu, G., Heinsen, F.-A., Tempel, M., Zhao, L., Lieb, W., Franke, A., Bromberg, Y., 2018. Functional sequencing read annotation for high precision microbiome analysis. Nucleic Acids Res. 46, e23. doi.org/10.1093/nar/gkx1209

2017

Bauer, C.R., Knecht, C., Fretter, C., Baum, B., Jendrossek, S., Rühlemann, M., Heinsen, F.-A., Umbach, N., Grimbacher, B., Franke, A., Lieb, W., Krawczak, M., Hütt, M.-T., Sax, U., 2017. Interdisciplinary approach towards a systems medicine toolbox using the example of inflammatory diseases. Brief. Bioinformatics 18, 479–487. doi.org/10.1093/bib/bbw024

Baum, B., Bauer, C., Franke, T., Kusch, H., Parciak, M., Rottmann, T., Umbach, N., Sax, U., 2017. Opinion paper: Data provenance challenges in biomedical research. it - Information Technology.

Baumgart, S., Peddinghaus, A., Schulte-Wrede, U., Mei, H.E., Grützkau, A., 2017a. OMIP-034: Comprehensive immune phenotyping of human peripheral leukocytes by mass cytometry for monitoring immunomodulatory therapies. Cytometry A 91, 34–38. doi.org/10.1002/cyto.a.22894

Baumgart, S., Schulz, A.R., Peddinghaus, A., Stanislawiak, S., Gillert, S., Hirseland, H., Krauthäuser, S., Dose, C., Mei, H.E., Grützkau, A., 2017b. Dual-labelled antibodies for flow and mass cytometry: A new tool for cross-platform comparison and enrichment of target cells for mass cytometry. Eur. J. Immunol. doi.org/10.1002/eji.201747031

Brænne, I., Zeng, L., Willenborg, C., Tragante, V., Kessler, T., CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer, C.J., Laakso, M., Wallentin, L., Franks, P.W., Salomaa, V., Dehghan, A., Meitinger, T., Samani, N.J., Asselbergs, F.W., Erdmann, J., Schunkert, H., 2017. Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. PLoS ONE 12, e0182999. doi.org/10.1371/journal.pone.0182999

Cavallari, J.F., Fullerton, M.D., Duggan, B.M., Foley, K.P., Denou, E., Smith, B.K., Desjardins, E.M., Henriksbo, B.D., Kim, K.J., Tuinema, B.R., Stearns, J.C., Prescott, D., Rosenstiel, P., Coombes, B.K., Steinberg, G.R., Schertzer, J.D., 2017. Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. Cell Metab. doi.org/10.1016/j.cmet.2017.03.021

Claussen, J.C., Skiecevičienė, J., Wang, J., Rausch, P., Karlsen, T.H., Lieb, W., Baines, J.F., Franke, A., Hütt, M.-T., 2017. Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome. PLoS Comput. Biol. 13, e1005361. doi.org/10.1371/journal.pcbi.1005361

Dand, N., Mucha, S., Tsoi, L.C., Mahil, S.K., Stuart, P.E., Arnold, A., Baurecht, H., Burden, A.D., Callis Duffin, K., Chandran, V., Curtis, C.J., Das, S., Ellinghaus, D., Ellinghaus, E., Enerback, C., Esko, T., Gladman, D.D., Griffiths, C.E.M., Gudjonsson, J.E., Hoffman, P., Homuth, G., Hüffmeier, U., Krueger, G.G., Laudes, M., Lee, S.H., Lieb, W., Lim, H.W., Löhr, S., Mrowietz, U., Müller-Nurayid, M., Nöthen, M., Peters, A., Rahman, P., Reis, A., Reynolds, N.J., Rodriguez, E., Schmidt, C.O., Spain, S.L., Strauch, K., Tejasvi, T., Voorhees, J.J., Warren, R.B., Weichenthal, M., Weidinger, S., Zawistowski, M., Nair, R.P., Capon, F., Smith, C.H., Trembath, R.C., Abecasis, G.R., Elder, J.T., Franke, A., Simpson, M.A., Barker, J.N., 2017. Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling. Hum. Mol. Genet. 26, 4301–4313. doi.org/10.1093/hmg/ddx328

Ellinghaus, E., Ellinghaus, D., Krusche, P., Greiner, A., Schreiber, C., Nikolaus, S., Gieger, C., Strauch, K., Lieb, W., Rosenstiel, P., Frings, N., Fiebig, A., Schreiber, S., Franke, A., 2017. Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci. Sci Rep 7, 45652. doi.org/10.1038/srep45652

Fangmann, D., Theismann, E.-M., Türk, K., Schulte, D.M., Relling, I., Hartmann, K., Keppler, J.K., Knipp, J.-R., Rehman, A., Heinsen, F.-A., Franke, A., Lenk, L., Freitag-Wolf, S., Appel, E., Gorb, S., Brenner, C., Seegert, D., Waetzig, G.H., Rosenstiel, P., Schreiber, S., Schwarz, K., Laudes, M., 2017. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans. Diabetes Care. doi.org/10.2337/dc17-1967

Gámez-Díaz, L., Neumann, J., Jäger, F., Proietti, M., Felber, F., Soulas-Sprauel, P., Perruzza, L., Grassi, F., Kögl, T., Aichele, P., Kilimann, M., Grimbacher, B., Jung, S., 2017. Immunological phenotype of the murine Lrba knockout. Immunol. Cell Biol. 95, 789–802. doi.org/10.1038/icb.2017.52

Guo, Y., Baumgart, S., Stärk, H.-J., Harms, H., Müller, S., 2017. Mass Cytometry for Detection of Silver at the Bacterial Single Cell Level. Front Microbiol 8, 1326. doi.org/10.3389/fmicb.2017.01326

Hermann, H., Runnel, T., Aab, A., Baurecht, H., Rodriguez, E., Magilnick, N., Urgard, E., Šahmatova, L., Prans, E., Maslovskaja, J., Abram, K., Karelson, M., Kaldvee, B., Reemann, P., Haljasorg, U., Rückert, B., Wawrzyniak, P., Weichenthal, M., Mrowietz, U., Franke, A., Gieger, C., Barker, J., Trembath, R., Tsoi, L.C., Elder, J.T., Tkaczyk, E.R., Kisand, K., Peterson, P., Kingo, K., Boldin, M., Weidinger, S., Akdis, C.A., Rebane, A., 2017. miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. J. Invest. Dermatol. 137, 1945–1954. doi.org/10.1016/j.jid.2017.05.012

Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C.A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D’Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K.K.-H., Franke, A., Gori, A.-S., Goyette, P., Halfvarson, J., Haritunians, T., Knight, J., Lawrance, I.C., Lees, C.W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S.L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R.J., International Inflammatory Bowel Disease Genetics Consortium, Weersma, R.K., Duerr, R.H., Mathew, C.G., Rioux, J.D., McGovern, D.P.B., Cho, J.H., Georges, M., Daly, M.J., Barrett, J.C., 2017. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature 547, 173–178. doi.org/10.1038/nature22969

Ji, S.-G., Juran, B.D., Mucha, S., Folseraas, T., Jostins, L., Melum, E., Kumasaka, N., Atkinson, E.J., Schlicht, E.M., Liu, J.Z., Shah, T., Gutierrez-Achury, J., Boberg, K.M., Bergquist, A., Vermeire, S., Eksteen, B., Durie, P.R., Farkkila, M., Müller, T., Schramm, C., Sterneck, M., Weismüller, T.J., Gotthardt, D.N., Ellinghaus, D., Braun, F., Teufel, A., Laudes, M., Lieb, W., Jacobs, G., Beuers, U., Weersma, R.K., Wijmenga, C., Marschall, H.-U., Milkiewicz, P., Pares, A., Kontula, K., Chazouillères, O., Invernizzi, P., Goode, E., Spiess, K., Moore, C., Sambrook, J., Ouwehand, W.H., Roberts, D.J., Danesh, J., Floreani, A., Gulamhusein, A.F., Eaton, J.E., Schreiber, S., Coltescu, C., Bowlus, C.L., Luketic, V.A., Odin, J.A., Chopra, K.B., Kowdley, K.V., Chalasani, N., Manns, M.P., Srivastava, B., Mells, G., Sandford, R.N., Alexander, G., Gaffney, D.J., Chapman, R.W., Hirschfield, G.M., de Andrade, M., UK-PSC Consortium, International IBD Genetics Consortium, International PSC Study Group, Rushbrook, S.M., Franke, A., Karlsen, T.H., Lazaridis, K.N., Anderson, C.A., 2017. Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nat. Genet. 49, 269–273. doi.org/10.1038/ng.3745

Knecht, C., Mort, M., Junge, O., Cooper, D.N., Krawczak, M., Caliebe, A., 2017. IMHOTEP-a composite score integrating popular tools for predicting the functional consequences of non-synonymous sequence variants. Nucleic Acids Res. 45, e13. doi.org/10.1093/nar/gkw886

Koch, M., Freitag-Wolf, S., Schlesinger, S., Borggrefe, J., Hov, J.R., Jensen, M.K., Pick, J., Markus, M.R.P., Höpfner, T., Jacobs, G., Siegert, S., Artati, A., Kastenmüller, G., Römisch-Margl, W., Adamski, J., Illig, T., Nothnagel, M., Karlsen, T.H., Schreiber, S., Franke, A., Krawczak, M., Nöthlings, U., Lieb, W., 2017. Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. Eur J Clin Nutr 71, 995–1001. doi.org/10.1038/ejcn.2017.43

Luedde, M., Winkler, T., Heinsen, F.-A., Rühlemann, M.C., Spehlmann, M.E., Bajrovic, A., Lieb, W., Franke, A., Ott, S.J., Frey, N., 2017. Heart failure is associated with depletion of core intestinal microbiota. ESC Heart Failure n/a-n/a. doi.org/10.1002/ehf2.12155

Meißner, T., Mark, A., Williams, C., Berdel, W.E., Wiebe, S., Kerkhoff, A., Wardelmann, E., Gaiser, T., Müller-Tidow, C., Rosenstiel, P., Arnold, N., Leyland-Jones, B., Franke, A., Stanulla, M., Forster, M., 2017. Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events. Cold Spring Harb Mol Case Stud 3. doi.org/10.1101/mcs.a001677

Petersen, B.-S., Fredrich, B., Hoeppner, M.P., Ellinghaus, D., Franke, A., 2017. Opportunities and challenges of whole-genome and -exome sequencing. BMC Genet. 18, 14. doi.org/10.1186/s12863-017-0479-5

Pomozi, V., Brampton, C., van de Wetering, K., Zoll, J., Calio, B., Pham, K., Owens, J.B., Marh, J., Moisyadi, S., Váradi, A., Martin, L., Bauer, C., Erdmann, J., Aherrahrou, Z., Le Saux, O., 2017. Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice. Am. J. Pathol. doi.org/10.1016/j.ajpath.2017.02.009

Rühlemann, M.C., Heinsen, F.-A., Zenouzi, R., Lieb, W., Franke, A., Schramm, C., 2017. Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis. Gut 66, 753–754. doi.org/10.1136/gutjnl-2016-312180

Schepp, J., Chou, J., Skrabl-Baumgartner, A., Arkwright, P.D., Engelhardt, K.R., Hambleton, S., Morio, T., Röther, E., Warnatz, K., Geha, R., Grimbacher, B., 2017a. 14 Years after Discovery: Clinical Follow-up on 15 Patients with Inducible Co-Stimulator Deficiency. Front. Immunol. 8. doi.org/10.3389/fimmu.2017.00964

Schepp, J., Proietti, M., Frede, N., Buchta, M., Hübscher, K., Rojas Restrepo, J., Goldacker, S., Warnatz, K., Pachlopnik Schmid, J., Duppenthaler, A., Lougaris, V., Uriarte, I., Kelly, S., Hershfield, M., Grimbacher, B., 2017b. Screening of 181 Patients With Antibody Deficiency for Deficiency of Adenosine Deaminase 2 Sheds New Light on the Disease in Adulthood. Arthritis & Rheumatology (Hoboken, N.J.) 69, 1689–1700. doi.org/10.1002/art.40147

Schubert, D., Klein, M.-C., Hassdenteufel, S., Caballero-Oteyza, A., Yang, L., Proietti, M., Bulashevska, A., Kemming, J., Kühn, J., Winzer, S., Rusch, S., Fliegauf, M., Schäffer, A.A., Pfeffer, S., Geiger, R., Cavalié, A., Cao, H., Yang, F., Li, Y., Rizzi, M., Eibel, H., Kobbe, R., Marks, A.L., Peppers, B.P., Hostoffer, R.W., Puck, J.M., Zimmermann, R., Grimbacher, B., 2017. Plasma cell deficiency in humans with heterozygous mutations in SEC61A1. J. Allergy Clin. Immunol. doi.org/10.1016/j.jaci.2017.06.042

Schulz, A.R., Stanislawiak, S., Baumgart, S., Grützkau, A., Mei, H.E., 2017. Silver nanoparticles for the detection of cell surface antigens in mass cytometry. Cytometry A 91, 25–33. doi.org/10.1002/cyto.a.22904

Sommer, F., Anderson, J.M., Bharti, R., Raes, J., Rosenstiel, P., 2017. The resilience of the intestinal microbiota influences health and disease. Nat. Rev. Microbiol. doi.org/10.1038/nrmicro.2017.58

Standl, M., Tesch, F., Baurecht, H., Rodríguez, E., Müller-Nurasyid, M., Gieger, C., Peters, A., Wang-Sattler, R., Prehn, C., Adamski, J., Kronenberg, F., Schulz, H., Koletzko, S., Schikowski, T., von Berg, A., Lehmann, I., Berdel, D., Heinrich, J., Schmitt, J., Weidinger, S., 2017. Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases. J. Invest. Dermatol. 137, 1074–1081. doi.org/10.1016/j.jid.2016.11.031

Tsoi, L.C., Stuart, P.E., Tian, C., Gudjonsson, J.E., Das, S., Zawistowski, M., Ellinghaus, E., Barker, J.N., Chandran, V., Dand, N., Duffin, K.C., Enerbäck, C., Esko, T., Franke, A., Gladman, D.D., Hoffmann, P., Kingo, K., Kõks, S., Krueger, G.G., Lim, H.W., Metspalu, A., Mrowietz, U., Mucha, S., Rahman, P., Reis, A., Tejasvi, T., Trembath, R., Voorhees, J.J., Weidinger, S., Weichenthal, M., Wen, X., Eriksson, N., Kang, H.M., Hinds, D.A., Nair, R.P., Abecasis, G.R., Elder, J.T., 2017. Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nat Commun 8, 15382. doi.org/10.1038/ncomms15382

Webb, T.R., Erdmann, J., Stirrups, K.E., Stitziel, N.O., Masca, N.G.D., Jansen, H., Kanoni, S., Nelson, C.P., Ferrario, P.G., König, I.R., Eicher, J.D., Johnson, A.D., Hamby, S.E., Betsholtz, C., Ruusalepp, A., Franzén, O., Schadt, E.E., Björkegren, J.L.M., Weeke, P.E., Auer, P.L., Schick, U.M., Lu, Y., Zhang, H., Dube, M.-P., Goel, A., Farrall, M., Peloso, G.M., Won, H.-H., Do, R., van Iperen, E., Kruppa, J., Mahajan, A., Scott, R.A., Willenborg, C., Braund, P.S., van Capelleveen, J.C., Doney, A.S.F., Donnelly, L.A., Asselta, R., Merlini, P.A., Duga, S., Marziliano, N., Denny, J.C., Shaffer, C., El-Mokhtari, N.E., Franke, A., Heilmann, S., Hengstenberg, C., Hoffmann, P., Holmen, O.L., Hveem, K., Jansson, J.-H., Jöckel, K.-H., Kessler, T., Kriebel, J., Laugwitz, K.L., Marouli, E., Martinelli, N., McCarthy, M.I., Van Zuydam, N.R., Meisinger, C., Esko, T., Mihailov, E., Escher, S.A., Alver, M., Moebus, S., Morris, A.D., Virtamo, J., Nikpay, M., Olivieri, O., Provost, S., AlQarawi, A., Robertson, N.R., Akinsansya, K.O., Reilly, D.F., Vogt, T.F., Yin, W., Asselbergs, F.W., Kooperberg, C., Jackson, R.D., Stahl, E., Müller-Nurasyid, M., Strauch, K., Varga, T.V., Waldenberger, M., Zeng, L., Chowdhury, R., Salomaa, V., Ford, I., Jukema, J.W., Amouyel, P., Kontto, J., Nordestgaard, B.G., Ferrières, J., Saleheen, D., Sattar, N., Surendran, P., Wagner, A., Young, R., Howson, J.M.M., Butterworth, A.S., Danesh, J., Ardissino, D., Bottinger, E.P., Erbel, R., Franks, P.W., Girelli, D., Hall, A.S., Hovingh, G.K., Kastrati, A., Lieb, W., Meitinger, T., Kraus, W.E., Shah, S.H., McPherson, R., Orho-Melander, M., Melander, O., Metspalu, A., Palmer, C.N.A., Peters, A., Rader, D.J., Reilly, M.P., Loos, R.J.F., Reiner, A.P., Roden, D.M., Tardif, J.-C., Thompson, J.R., Wareham, N.J., Watkins, H., Willer, C.J., Samani, N.J., Schunkert, H., Deloukas, P., Kathiresan, S., 2017. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology 69, 823–836. doi.org/10.1016/j.jacc.2016.11.056

Witoelar, A., Jansen, I.E., Wang, Y., Desikan, R.S., Gibbs, J.R., Blauwendraat, C., Thompson, W.K., Hernandez, D.G., Djurovic, S., Schork, A.J., Bettella, F., Ellinghaus, D., Franke, A., Lie, B.A., McEvoy, L.K., Karlsen, T.H., Lesage, S., Morris, H.R., Brice, A., Wood, N.W., Heutink, P., Hardy, J., Singleton, A.B., Dale, A.M., Gasser, T., Andreassen, O.A., Sharma, M., International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators, 2017. Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. JAMA Neurol 74, 780–792. doi.org/10.1001/jamaneurol.2017.0469

Yadav, P., Ellinghaus, D., Rémy, G., Freitag-Wolf, S., Cesaro, A., Degenhardt, F., Boucher, G., Delacre, M., International IBD Genetics Consortium, Peyrin-Biroulet, L., Pichavant, M., Rioux, J.D., Gosset, P., Franke, A., Schumm, L.P., Krawczak, M., Chamaillard, M., Dempfle, A., Andersen, V., 2017. Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice. Gastroenterology 153, 550–565. doi.org/10.1053/j.gastro.2017.05.010

2016

Aherrahrou, Z., Schlossarek, S., Stoelting, S., Klinger, M., Geertz, B., Weinberger, F., Kessler, T., Aherrahrou, R., Moreth, K., Bekeredjian, R., Hrabě de Angelis, M., Just, S., Rottbauer, W., Eschenhagen, T., Schunkert, H., Carrier, L., Erdmann, J., 2016. Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis. Basic Res. Cardiol. 111, 6. doi.org/10.1007/s00395-015-0522-5

Bauer, C.R.K.D., Ganslandt, T., Baum, B., Christoph, J., Engel, I., Löbe, M., Mate, S., Stäubert, S., Drepper, J., Prokosch, H.-U., Winter, A., Sax, U., 2016. Integrated Data Repository Toolkit (IDRT). A Suite of Programs to Facilitate Health Analytics on Heterogeneous Medical Data. Methods Inf Med 55, 125–135. doi.org/10.3414/ME15-01-0082

Baurecht, H., Hotze, M., Rodríguez, E., Manz, J., Weidinger, S., Cordell, H.J., Augustin, T., Strauch, K., 2016. Compare and Contrast Meta Analysis (CCMA): A Method for Identification of Pleiotropic Loci in Genome-Wide Association Studies. PLoS ONE 11, e0154872. doi.org/10.1371/journal.pone.0154872

Beber, M.E., Muskhelishvili, G., Hütt, M.-T., 2016. Effect of database drift on network topology and enrichment analyses: a case study for RegulonDB. Database (Oxford) 2016. doi.org/10.1093/database/baw003

Depner, M., Fuchs, S., Raabe, J., Frede, N., Glocker, C., Doffinger, R., Gkrania-Klotsas, E., Kumararatne, D., Atkinson, T.P., Schroeder, H.W., Niehues, T., Dückers, G., Stray-Pedersen, A., Baumann, U., Schmidt, R., Franco, J.L., Orrego, J., Ben-Shoshan, M., McCusker, C., Jacob, C.M.A., Carneiro-Sampaio, M., Devlin, L.A., Edgar, J.D.M., Henderson, P., Russell, R.K., Skytte, A.-B., Seneviratne, S.L., Wanders, J., Stauss, H., Meyts, I., Moens, L., Jesenak, M., Kobbe, R., Borte, S., Borte, M., Wright, D.A., Hagin, D., Torgerson, T.R., Grimbacher, B., 2016. The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1. J. Clin. Immunol. 36, 73–84. doi.org/10.1007/s10875-015-0214-9

Ellinghaus, D., Jostins, L., Spain, S.L., Cortes, A., Bethune, J., Han, B., Park, Y.R., Raychaudhuri, S., Pouget, J.G., Hübenthal, M., Folseraas, T., Wang, Y., Esko, T., Metspalu, A., Westra, H.-J., Franke, L., Pers, T.H., Weersma, R.K., Collij, V., D’Amato, M., Halfvarson, J., Jensen, A.B., Lieb, W., Degenhardt, F., Forstner, A.J., Hofmann, A., International IBD Genetics Consortium (IIBDGC), International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Genetic Analysis of Psoriasis Consortium (GAPC), Psoriasis Association Genetics Extension (PAGE), Schreiber, S., Mrowietz, U., Juran, B.D., Lazaridis, K.N., Brunak, S., Dale, A.M., Trembath, R.C., Weidinger, S., Weichenthal, M., Ellinghaus, E., Elder, J.T., Barker, J.N.W.N., Andreassen, O.A., McGovern, D.P., Karlsen, T.H., Barrett, J.C., Parkes, M., Brown, M.A., Franke, A., 2016. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat. Genet. 48, 510–518. doi.org/10.1038/ng.3528

Flachsbart, F., Ellinghaus, D., Gentschew, L., Heinsen, F.-A., Caliebe, A., Christiansen, L., Nygaard, M., Christensen, K., Blanché, H., Deleuze, J.-F., Derbois, C., Galan, P., Büning, C., Brand, S., Peters, A., Strauch, K., Müller-Nurasyid, M., Hoffmann, P., Nöthen, M.M., Lieb, W., Franke, A., Schreiber, S., Nebel, A., 2016. Immunochip analysis identifies association of the RAD50/IL13 region with human longevity. Aging Cell 15, 585–588. doi.org/10.1111/acel.12471

Gámez-Díaz, L., August, D., Stepensky, P., Revel-Vilk, S., Seidel, M.G., Noriko, M., Morio, T., Worth, A.J.J., Blessing, J., Van de Veerdonk, F., Feuchtinger, T., Kanariou, M., Schmitt-Graeff, A., Jung, S., Seneviratne, S., Burns, S., Belohradsky, B.H., Rezaei, N., Bakhtiar, S., Speckmann, C., Jordan, M., Grimbacher, B., 2016. The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency. J. Allergy Clin. Immunol. 137, 223–230. doi.org/10.1016/j.jaci.2015.09.025

Häsler, R., Sheibani-Tezerji, R., Sinha, A., Barann, M., Rehman, A., Esser, D., Aden, K., Knecht, C., Brandt, B., Nikolaus, S., Schäuble, S., Kaleta, C., Franke, A., Fretter, C., Müller, W., Hütt, M.-T., Krawczak, M., Schreiber, S., Rosenstiel, P., 2016. Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease. Gut. doi.org/10.1136/gutjnl-2016-311651

Heinsen, F.-A., Fangmann, D., Müller, N., Schulte, D.M., Rühlemann, M.C., Türk, K., Settgast, U., Lieb, W., Baines, J.F., Schreiber, S., Franke, A., Laudes, M., 2016. Beneficial Effects of a Dietary Weight Loss Intervention on Human Gut Microbiome Diversity and Metabolism Are Not Sustained during Weight Maintenance. Obes Facts 9, 379–391. doi.org/10.1159/000449506

Knecht, C., Fretter, C., Rosenstiel, P., Krawczak, M., Hütt, M.-T., 2016a. Distinct metabolic network states manifest in the gene expression profiles of pediatric inflammatory bowel disease patients and controls. Sci Rep 6, 32584. doi.org/10.1038/srep32584

Lacour, A., Ellinghaus, D., Schreiber, S., Franke, A., Becker, T., 2016. Haplotype synthesis analysis reveals functional variants underlying known genome-wide associated susceptibility loci. Bioinformatics 32, 2136–2142. doi.org/10.1093/bioinformatics/btw125

Manz, J., Rodríguez, E., ElSharawy, A., Oesau, E.-M., Petersen, B.-S., Baurecht, H., Mayr, G., Weber, S., Harder, J., Reischl, E., Schwarz, A., Novak, N., Franke, A., Weidinger, S., 2016. Targeted Resequencing and Functional Testing Identifies Low-Frequency Missense Variants in the Gene Encoding GARP as Significant Contributors to Atopic Dermatitis Risk. J. Invest. Dermatol. 136, 2380–2386. doi.org/10.1016/j.jid.2016.07.009

Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, 2016. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N. Engl. J. Med. 374, 1134–1144. doi.org/10.1056/NEJMoa1507652

Rivera, N.V., Ronninger, M., Shchetynsky, K., Franke, A., Nöthen, M.M., Müller-Quernheim, J., Schreiber, S., Adrianto, I., Karakaya, B., van Moorsel, C.H.M., Navratilova, Z., Kolek, V., Rybicki, B.A., Iannuzzi, M.C., Petrek, M., Grutters, J.C., Montgomery, C., Fischer, A., Eklund, A., Padyukov, L., Grunewald, J., 2016. High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences. Am. J. Respir. Crit. Care Med. 193, 1008–1022. doi.org/10.1164/rccm.201507-1372OC

Rühlemann, M.C., Heinsen, F.-A., Zenouzi, R., Lieb, W., Franke, A., Schramm, C., 2016. Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis. Gut. doi.org/10.1136/gutjnl-2016-312180

Schepp, J., Bulashevska, A., Mannhardt-Laakmann, W., Cao, H., Yang, F., Seidl, M., Kelly, S., Hershfield, M., Grimbacher, B., 2016. Deficiency of Adenosine Deaminase 2 Causes Antibody Deficiency. J. Clin. Immunol. 36, 179–186. doi.org/10.1007/s10875-016-0245-x

Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Fölster-Holst, R., Rodríguez, E., Lee, Y.A.E., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nöthen, M.M., Irvine, A.D., McLean, W.H.I., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N., Weidinger, S., 2016. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J. Allergy Clin. Immunol. 137, 130–136. doi.org/10.1016/j.jaci.2015.06.029

Schreiner, F., Plamper, M., Dueker, G., Schoenberger, S., Gámez-Díaz, L., Grimbacher, B., Hilger, A.C., Gohlke, B., Reutter, H., Woelfle, J., 2016. Infancy-Onset T1DM, Short Stature, and Severe Immunodysregulation in Two Siblings With a Homozygous LRBA Mutation. J. Clin. Endocrinol. Metab. 101, 898–904. doi.org/10.1210/jc.2015-3382

Wang, J., Thingholm, L.B., Skiecevičienė, J., Rausch, P., Kummen, M., Hov, J.R., Degenhardt, F., Heinsen, F.-A., Rühlemann, M.C., Szymczak, S., Holm, K., Esko, T., Sun, J., Pricop-Jeckstadt, M., Al-Dury, S., Bohov, P., Bethune, J., Sommer, F., Ellinghaus, D., Berge, R.K., Hübenthal, M., Koch, M., Schwarz, K., Rimbach, G., Hübbe, P., Pan, W.-H., Sheibani-Tezerji, R., Häsler, R., Rosenstiel, P., D’Amato, M., Cloppenborg-Schmidt, K., Künzel, S., Laudes, M., Marschall, H.-U., Lieb, W., Nöthlings, U., Karlsen, T.H., Baines, J.F., Franke, A., 2016. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nat. Genet. 48, 1396–1406. doi.org/10.1038/ng.3695

Weidinger, S., Rodríguez, E., Kabesch, M., 2016. Genetik und Epigenetik von allergischen Erkrankungen und Asthma, in: Biedermann, T., Heppt, W., Renz, H., Röcken, M. (Eds.), Allergologie. Springer Berlin Heidelberg, pp. 23–36. doi.org/10.1007/978-3-642-37203-2_3

Westerlind, H., Bonfiglio, F., Mellander, M.-R., Hìbenthal, M., Brynedal, B., Björk, J., Törkvist, L., Padyukov, L., Ohlsson, B., Löfberg, R., Hultcrantz, R., Franke, A., Bresso, F., D’Amato, M., 2016. HLA Associations Distinguish Collagenous From Lymphocytic Colitis. Am. J. Gastroenterol. 111, 1211–1213. http://doi.org/10.1038/ajg.2016.215

2015

Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A.D., Kabesch, M., Lee, Y.A.E., Lieb, W., Marenholz, I., McLean, W.H.I., Morris, D.W., Mrowietz, U., Nair, R., Nöthen, M.M., Novak, N., O’Regan, G.M., Psoriasis Association Genetics Extension, Schreiber, S., Smith, C., Strauch, K., Stuart, P.E., Trembath, R., Tsoi, L.C., Weichenthal, M., Barker, J., Elder, J.T., Weidinger, S., Cordell, H.J., Brown, S.J., 2015. Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am. J. Hum. Genet. 96, 104–120. doi.org/10.1016/j.ajhg.2014.12.004

Brænne, I., Civelek, M., Vilne, B., Di Narzo, A., Johnson, A.D., Zhao, Y., Reiz, B., Codoni, V., Webb, T.R., Foroughi Asl, H., Hamby, S.E., Zeng, L., Trégouët, D.-A., Hao, K., Topol, E.J., Schadt, E.E., Yang, X., Samani, N.J., Björkegren, J.L.M., Erdmann, J., Schunkert, H., Lusis, A.J., Leducq Consortium CAD Genomics‡, 2015. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler. Thromb. Vasc. Biol. 35, 2207–2217. doi.org/10.1161/ATVBAHA.115.306108

Buch, S., Stickel, F., Trépo, E., Way, M., Herrmann, A., Nischalke, H.D., Brosch, M., Rosendahl, J., Berg, T., Ridinger, M., Rietschel, M., McQuillin, A., Frank, J., Kiefer, F., Schreiber, S., Lieb, W., Soyka, M., Semmo, N., Aigner, E., Datz, C., Schmelz, R., Brückner, S., Zeissig, S., Stephan, A.-M., Wodarz, N., Devière, J., Clumeck, N., Sarrazin, C., Lammert, F., Gustot, T., Deltenre, P., Völzke, H., Lerch, M.M., Mayerle, J., Eyer, F., Schafmayer, C., Cichon, S., Nöthen, M.M., Nothnagel, M., Ellinghaus, D., Huse, K., Franke, A., Zopf, S., Hellerbrand, C., Moreno, C., Franchimont, D., Morgan, M.Y., Hampe, J., 2015. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat. Genet. 47, 1443–1448. doi.org/10.1038/ng.3417

Fischer, A., Ellinghaus, D., Nutsua, M., Hofmann, S., Montgomery, C.G., Iannuzzi, M.C., Rybicki, B.A., Petrek, M., Mrazek, F., Pabst, S., Grohé, C., Grunewald, J., Ronninger, M., Eklund, A., Padyukov, L., Mihailovic-Vucinic, V., Jovanovic, D., Sterclova, M., Homolka, J., Nöthen, M.M., Herms, S., Gieger, C., Strauch, K., Winkelmann, J., Boehm, B.O., Brand, S., Büning, C., Schürmann, M., Ellinghaus, E., Baurecht, H., Lieb, W., Nebel, A., Müller-Quernheim, J., Franke, A., Schreiber, S., GenPhenReSa Consortium, 2015. Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk. Am. J. Respir. Crit. Care Med. 192, 727–736. doi.org/10.1164/rccm.201503-0418OC

Fliegauf, M., Bryant, V.L., Frede, N., Slade, C., Woon, S.-T., Lehnert, K., Winzer, S., Bulashevska, A., Scerri, T., Leung, E., Jordan, A., Keller, B., de Vries, E., Cao, H., Yang, F., Schäffer, A.A., Warnatz, K., Browett, P., Douglass, J., Ameratunga, R.V., van der Meer, J.W.M., Grimbacher, B., 2015. Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency. Am. J. Hum. Genet. 97, 389–403. doi.org/10.1016/j.ajhg.2015.07.008

Goyette, P., Boucher, G., Mallon, D., Ellinghaus, E., Jostins, L., Huang, H., Ripke, S., Gusareva, E.S., Annese, V., Hauser, S.L., Oksenberg, J.R., Thomsen, I., Leslie, S., International Inflammatory Bowel Disease Genetics Consortium, Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium, Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium, United Kingdom IBDGC, Wellcome Trust Case Control Consortium, Quebec IBD Genetics Consortium, Daly, M.J., Van Steen, K., Duerr, R.H., Barrett, J.C., McGovern, D.P.B., Schumm, L.P., Traherne, J.A., Carrington, M.N., Kosmoliaptsis, V., Karlsen, T.H., Franke, A., Rioux, J.D., 2015. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat. Genet. 47, 172–179. doi.org/10.1038/ng.3176

Koch, M., Baurecht, H., Ried, J.S., Rodriguez, E., Schlesinger, S., Volks, N., Gieger, C., Rückert, I.-M., Heinrich, L., Willenborg, C., Smith, C., Peters, A., Thorand, B., Koenig, W., Lamina, C., Jansen, H., Kronenberg, F., Seissler, J., Thiery, J., Rathmann, W., Schunkert, H., Erdmann, J., Barker, J., Nair, R.P., Tsoi, L.C., Elder, J.T., Mrowietz, U., Weichenthal, M., Mucha, S., Schreiber, S., Franke, A., Schmitt, J., Lieb, W., Weidinger, S., 2015. Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures. J. Invest. Dermatol. 135, 1283–1293. doi.org/10.1038/jid.2015.8

Kunz, M., König, I.R., Schillert, A., Kruppa, J., Ziegler, A., Grallert, H., Müller-Nurasyid, M., Lieb, W., Franke, A., Ranki, A., Panelius, J., Koskenmies, S., Hasan, T., Kere, J., Rönn, A.-C., Simon, J.C., Schmidt, E., Wenzel, J., Tüting, T., Landsberg, J., Zeller, T., Blankenberg, S., Gläser, R., Patsinakidis, N., Kuhn, A., Ibrahim, S.M., 2015. Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus. Exp. Dermatol. 24, 510–515. doi.org/10.1111/exd.12708

Li, J., Jørgensen, S.F., Maggadottir, S.M., Bakay, M., Warnatz, K., Glessner, J., Pandey, R., Salzer, U., Schmidt, R.E., Perez, E., Resnick, E., Goldacker, S., Buchta, M., Witte, T., Padyukov, L., Videm, V., Folseraas, T., Atschekzei, F., Elder, J.T., Nair, R.P., Winkelmann, J., Gieger, C., Nöthen, M.M., Büning, C., Brand, S., Sullivan, K.E., Orange, J.S., Fevang, B., Schreiber, S., Lieb, W., Aukrust, P., Chapel, H., Cunningham-Rundles, C., Franke, A., Karlsen, T.H., Grimbacher, B., Hakonarson, H., Hammarström, L., Ellinghaus, E., 2015. Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nat Commun 6, 6804. doi.org/10.1038/ncomms7804

Lindner, C., Thomsen, I., Wahl, B., Ugur, M., Sethi, M.K., Friedrichsen, M., Smoczek, A., Ott, S., Baumann, U., Suerbaum, S., Schreiber, S., Bleich, A., Gaboriau-Routhiau, V., Cerf-Bensussan, N., Hazanov, H., Mehr, R., Boysen, P., Rosenstiel, P., Pabst, O., 2015. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat. Immunol. 16, 880–888. doi.org/10.1038/ni.3213

Nikpay, M., Goel, A., Won, H.-H., Hall, L.M., Willenborg, C., Kanoni, S., Saleheen, D., Kyriakou, T., Nelson, C.P., Hopewell, J.C., Webb, T.R., Zeng, L., Dehghan, A., Alver, M., Armasu, S.M., Auro, K., Bjonnes, A., Chasman, D.I., Chen, S., Ford, I., Franceschini, N., Gieger, C., Grace, C., Gustafsson, S., Huang, J., Hwang, S.-J., Kim, Y.K., Kleber, M.E., Lau, K.W., Lu, X., Lu, Y., Lyytikäinen, L.-P., Mihailov, E., Morrison, A.C., Pervjakova, N., Qu, L., Rose, L.M., Salfati, E., Saxena, R., Scholz, M., Smith, A.V., Tikkanen, E., Uitterlinden, A., Yang, X., Zhang, W., Zhao, W., de Andrade, M., de Vries, P.S., van Zuydam, N.R., Anand, S.S., Bertram, L., Beutner, F., Dedoussis, G., Frossard, P., Gauguier, D., Goodall, A.H., Gottesman, O., Haber, M., Han, B.-G., Huang, J., Jalilzadeh, S., Kessler, T., König, I.R., Lannfelt, L., Lieb, W., Lind, L., Lindgren, C.M., Lokki, M.-L., Magnusson, P.K., Mallick, N.H., Mehra, N., Meitinger, T., Memon, F.-R., Morris, A.P., Nieminen, M.S., Pedersen, N.L., Peters, A., Rallidis, L.S., Rasheed, A., Samuel, M., Shah, S.H., Sinisalo, J., Stirrups, K.E., Trompet, S., Wang, L., Zaman, K.S., Ardissino, D., Boerwinkle, E., Borecki, I.B., Bottinger, E.P., Buring, J.E., Chambers, J.C., Collins, R., Cupples, L.A., Danesh, J., Demuth, I., Elosua, R., Epstein, S.E., Esko, T., Feitosa, M.F., Franco, O.H., Franzosi, M.G., Granger, C.B., Gu, D., Gudnason, V., Hall, A.S., Hamsten, A., Harris, T.B., Hazen, S.L., Hengstenberg, C., Hofman, A., Ingelsson, E., Iribarren, C., Jukema, J.W., Karhunen, P.J., Kim, B.-J., Kooner, J.S., Kullo, I.J., Lehtimäki, T., Loos, R.J.F., Melander, O., Metspalu, A., März, W., Palmer, C.N., Perola, M., Quertermous, T., Rader, D.J., Ridker, P.M., Ripatti, S., Roberts, R., Salomaa, V., Sanghera, D.K., Schwartz, S.M., Seedorf, U., Stewart, A.F., Stott, D.J., Thiery, J., Zalloua, P.A., O’Donnell, C.J., Reilly, M.P., Assimes, T.L., Thompson, J.R., Erdmann, J., Clarke, R., Watkins, H., Kathiresan, S., McPherson, R., Deloukas, P., Schunkert, H., Samani, N.J., Farrall, M., CARDIoGRAMplusC4D Consortium, 2015. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47, 1121–1130. doi.org/10.1038/ng.3396

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D.P., Curtin, J.A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A.C., Thyssen, J.P., den Dekker, H.T., Ferreira, M.A., Altmaier, E., Sleiman, P.M.A., Xiao, F.L., Gonzalez, J.R., Marenholz, I., Kalb, B., Pino-Yanes, M., Xu, C.-J., Carstensen, L., Groen-Blokhuis, M.M., Venturini, C., Pennell, C.E., Barton, S.J., Levin, A.M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G.A., Bacelis, J., Bunyavanich, S., Myers, R.A., Matanovic, A., Kumar, A., Tung, J.Y., Hirota, T., Kubo, M., McArdle, W.L., Henderson, A.J., Kemp, J.P., Zheng, J., Smith, G.D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M.A., Arnold, A., Homuth, G., Schmidt, C.O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L.L., Grarup, N., de Jongste, J.C., Rivadeneira, F., Hofman, A., Jaddoe, V.W.V., Pasmans, S.G.M.A., Elbert, N.J., Uitterlinden, A.G., Marks, G.B., Thompson, P.J., Matheson, M.C., Robertson, C.F., Australian Asthma Genetics Consortium (AAGC), Ried, J.S., Li, J., Zuo, X.B., Zheng, X.D., Yin, X.Y., Sun, L.D., McAleer, M.A., O’Regan, G.M., Fahy, C.M.R., Campbell, L.E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D.S., Feenstra, B., Geller, F., Hottenga, J.J., Middeldorp, C.M., Hysi, P., Bataille, V., Spector, T., Tiesler, C.M.T., Thiering, E., Pahukasahasram, B., Yang, J.J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C.L., Myhre, R., Nystad, W., Custovic, A., Weiss, S.T., Meyers, D.A., Söderhäll, C., Melén, E., Ober, C., Raby, B.A., Simpson, A., Jacobsson, B., Holloway, J.W., Bisgaard, H., Sunyer, J., Probst-Hensch, N.M., Williams, L.K., Godfrey, K.M., Wang, C.A., Boomsma, D.I., Melbye, M., Koppelman, G.H., Jarvis, D., McLean, W.H.I., Irvine, A.D., Zhang, X.J., Hakonarson, H., Gieger, C., Burchard, E.G., Martin, N.G., Duijts, L., Linneberg, A., Jarvelin, M.-R., Nöthen, M.M., Lau, S., Hübner, N., Lee, Y.-A., Tamari, M., Hinds, D.A., Glass, D., Brown, S.J., Heinrich, J., Evans, D.M., Weidinger, S., EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, 2015. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat. Genet. 47, 1449–1456. doi.org/10.1038/ng.3424

Schaarschmidt, H., Ellinghaus, D., Rodríguez, E., Kretschmer, A., Baurecht, H., Lipinski, S., Meyer-Hoffert, U., Harder, J., Lieb, W., Novak, N., Fölster-Holst, R., Esparza-Gordillo, J., Marenholz, I., Ruschendorf, F., Hubner, N., Reischl, E., Waldenberger, M., Gieger, C., Illig, T., Kabesch, M., Zhang, X.-J., Xiao, F.-L., Lee, Y.-A., Franke, A., Weidinger, S., 2015. A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis. J. Allergy Clin. Immunol. 136, 802–806. doi.org/10.1016/j.jaci.2015.01.047

Seidel, M.G., Hirschmugl, T., Gamez-Diaz, L., Schwinger, W., Serwas, N., Deutschmann, A., Gorkiewicz, G., Zenz, W., Windpassinger, C., Grimbacher, B., Urban, C., Boztug, K., 2015. Long-term remission after allogeneic hematopoietic stem cell transplantation in LPS-responsive beige-like anchor (LRBA) deficiency. J. Allergy Clin. Immunol. 135, 1384-1390–8. doi.org/10.1016/j.jaci.2014.10.048

Stuart, P.E., Nair, R.P., Tsoi, L.C., Tejasvi, T., Das, S., Kang, H.M., Ellinghaus, E., Chandran, V., Callis-Duffin, K., Ike, R., Li, Y., Wen, X., Enerbäck, C., Gudjonsson, J.E., Kõks, S., Kingo, K., Esko, T., Mrowietz, U., Reis, A., Wichmann, H.E., Gieger, C., Hoffmann, P., Nöthen, M.M., Winkelmann, J., Kunz, M., Moreta, E.G., Mease, P.J., Ritchlin, C.T., Bowcock, A.M., Krueger, G.G., Lim, H.W., Weidinger, S., Weichenthal, M., Voorhees, J.J., Rahman, P., Gregersen, P.K., Franke, A., Gladman, D.D., Abecasis, G.R., Elder, J.T., 2015. Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. Am. J. Hum. Genet. 97, 816–836. doi.org/10.1016/j.ajhg.2015.10.019

Tsoi, L.C., Spain, S.L., Ellinghaus, E., Stuart, P.E., Capon, F., Knight, J., Tejasvi, T., Kang, H.M., Allen, M.H., Lambert, S., Stoll, S.W., Weidinger, S., Gudjonsson, J.E., Koks, S., Kingo, K., Esko, T., Das, S., Metspalu, A., Weichenthal, M., Enerback, C., Krueger, G.G., Voorhees, J.J., Chandran, V., Rosen, C.F., Rahman, P., Gladman, D.D., Reis, A., Nair, R.P., Franke, A., Barker, J.N.W.N., Abecasis, G.R., Trembath, R.C., Elder, J.T., 2015. Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nat Commun 6, 7001. doi.org/10.1038/ncomms8001

Wehr, C., Gennery, A.R., Lindemans, C., Schulz, A., Hoenig, M., Marks, R., Recher, M., Gruhn, B., Holbro, A., Heijnen, I., Meyer, D., Grigoleit, G., Einsele, H., Baumann, U., Witte, T., Sykora, K.-W., Goldacker, S., Regairaz, L., Aksoylar, S., Ardeniz, Ö., Zecca, M., Zdziarski, P., Meyts, I., Matthes-Martin, S., Imai, K., Kamae, C., Fielding, A., Seneviratne, S., Mahlaoui, N., Slatter, M.A., Güngör, T., Arkwright, P.D., van Montfrans, J., Sullivan, K.E., Grimbacher, B., Cant, A., Peter, H.-H., Finke, J., Gaspar, H.B., Warnatz, K., Rizzi, M., Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiency, 2015. Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency. J. Allergy Clin. Immunol. 135, 988–997.e6. doi.org/10.1016/j.jaci.2014.11.029

Yin, X., Low, H.Q., Wang, L., Li, Y., Ellinghaus, E., Han, J., Estivill, X., Sun, L., Zuo, X., Shen, C., Zhu, C., Zhang, A., Sanchez, F., Padyukov, L., Catanese, J.J., Krueger, G.G., Duffin, K.C., Mucha, S., Weichenthal, M., Weidinger, S., Lieb, W., Foo, J.N., Li, Y., Sim, K., Liany, H., Irwan, I., Teo, Y., Theng, C.T.S., Gupta, R., Bowcock, A., De Jager, P.L., Qureshi, A.A., de Bakker, P.I.W., Seielstad, M., Liao, W., Ståhle, M., Franke, A., Zhang, X., Liu, J., 2015. Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun 6, 6916. doi.org/10.1038/ncomms7916

2014

 

 

Schubert, D., Bode, C., Kenefeck, R., Hou, T.Z., Wing, J.B., Kennedy, A., Bulashevska, A., Petersen, B.-S., Schäffer, A.A., Grüning, B.A., Unger, S., Frede, N., Baumann, U., Witte, T., Schmidt, R.E., Dueckers, G., Niehues, T., Seneviratne, S., Kanariou, M., Speckmann, C., Ehl, S., Rensing-Ehl, A., Warnatz, K., Rakhmanov, M., Thimme, R., Hasselblatt, P., Emmerich, F., Cathomen, T., Backofen, R., Fisch, P., Seidl, M., May, A., Schmitt-Graeff, A., Ikemizu, S., Salzer, U., Franke, A., Sakaguchi, S., Walker, L.S.K., Sansom, D.M., Grimbacher, B., 2014. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat. Med. 20, 1410–1416. doi.org/10.1038/nm.3746