CAPSyS

Publikationen

2023

Asmus, E., W. Karle, M. C. Brack, C. Wittig, F. Behrens, L. Reinshagen, M. Pfeiffer, S. Schulz, B. Mandzimba-Maloko, L. Erfinanda, P. L. Perret, L. Michalick, P. J. Smeele, E. H. T. Lim, C. E. van den Brom, A. B. A. Vonk, T. Kaiser, N. Suttorp, S. Hippenstiel, L. E. Sander, F. Kurth, U. Rauch, U. Landmesser, A. Haghikia, R. Preissner, H. J. Bogaard, M. Witzenrath, W. M. Kuebler, R. Szulcek, and S. Simmons (2023). "Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients." European Respiratory Journal 61(3). SYMPATH_ & CAPSyS  doi.org/10.1183/13993003.02009-2022.

Bierwagen, J., M. Wiegand, K. Laakmann, O. Danov, H. Limburg, S. M. Herbel, T. Heimerl, J. Dorna, D. Jonigk, C. Preußer, W. Bertrams, A. Braun, K. Sewald, L. N. Schulte, S. Bauer, E. Pogge von Strandmann, E. Böttcher-Friebertshäuser, B. Schmeck, and A. L. Jung (2023). "Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis." Cell Commun Signal 21(1): 1–15. CAPSyS  doi.org/10.1186/s12964-023-01086-4.

Felten, M., C. Dame, G. Lachmann, C. Spies, K. Rubarth, F. Balzer, A. Kramer, and M. Witzenrath (2023). "Circadian Rhythm Disruption in Critically Ill Patients." Acta Physiol n/a(n/a): e13962. CAPSyS & SYMPATH_  doi.org/10.1111/apha.13962.

Goekeri, C., P. Pennitz, W. Groenewald, U. Behrendt, H. Kirsten, C. M. Zobel, S. Berger, G. A. Heinz, M.-F. Mashreghi, S.-M. Wienhold, K. Dietert, A. Dorhoi, A. D. Gruber, M. Scholz, G. Rohde, N. Suttorp, C. S. Group, M. Witzenrath, and G. Nouailles (2023). "MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia." Cells 12(6): 959. CAPSyS & SYMPATH_  doi.org/10.3390/cells12060959.

Jung, A. L., M. Han, K. Griss, W. Bertrams, C. Nell, T. Greulich, A. Klemmer, H. Pott, D. Heider, C. F. Vogelmeier, S. Hippenstiel, N. Suttorp, and B. Schmeck (2023). "Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study." Front Med 10: 1180746. CAPSyS  doi.org/10.3389/fmed.2023.1180746.

Jung, A. L., M. Møller Jørgensen, R. Bæk, M. Artho, K. Griss, M. Han, W. Bertrams, T. Greulich, R. Koczulla, S. Hippenstiel, D. Heider, N. Suttorp, and B. Schmeck (2023). "Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria." Infection: 1–11. CAPSyS  doi.org/10.1007/s15010-023-02022-x.

Klabunde, B., A. Wesener, W. Bertrams, I. Beinborn, N. Paczia, K. Surmann, S. Blankenburg, J. Wilhelm, J. Serrania, K. Knoops, E. M. Elsayed, K. Laakmann, A. L. Jung, A. Kirschbaum, S. Hammerschmidt, B. Alshaar, N. Gisch, M. Abu Mraheil, A. Becker, U. Voelker, E. Vollmeister, B. J. Benedikter, and B. Schmeck (2023). "NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections." Nature Communications 14(1). CAPSYS  doi.org/10.1038/s41467-023-41372-w.

Nouailles, G., J. M. Adler, P. Pennitz, S. Peidli, L. G. Teixeira Alves, M. Baumgardt, J. Bushe, A. Voss, A. Langenhagen, C. Langner, R. Martin Vidal, F. Pott, J. Kazmierski, A. Ebenig, M. V. Lange, M. D. Mühlebach, C. Goekeri, S. Simmons, N. Xing, A. Abdelgawad, S. Herwig, G. Cichon, D. Niemeyer, C. Drosten, C. Goffinet, M. Landthaler, N. Blüthgen, H. Wu, M. Witzenrath, A. D. Gruber, S. D. Praktiknjo, N. Osterrieder, E. Wyler, D. Kunec, and J. Trimpert (2023). "Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters." Nat Microbiol: 1–15. CAPSyS & SYMPATH_  doi.org/10.1038/s41564-023-01352-8.

Pennitz, P., C. Goekeri, J. Trimpert, E. Wyler, A. Ebenig, C. Weissfuss, M. D. Mühlebach, M. Witzenrath, and G. Nouailles (2023). "Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis." STAR Protocols 4(1): 101957. CAPSyS & SYMPATH_  doi.org/10.1016/j.xpro.2022.101957.

Schwerdtner, M., A. Skalik, H. Limburg, J. Bierwagen, A. L. Jung, J. Dorna, A. Kaufmann, S. Bauer, B. Schmeck, and E. Böttcher-Friebertshäuser (2023). "Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells." Life Sci Alliance 6(8). CAPSyS  doi.org/10.26508/lsa.202201813.

Weissfuss, C., S.-M. Wienhold, M. Bürkle, B. Gaborieau, J. Bushe, U. Behrendt, R. Bischoff, I. H. E. Korf, S. Wienecke, A. Dannheim, H. Ziehr, C. Rohde, A. D. Gruber, J.-D. Ricard, L. Debarbieux, M. Witzenrath, and G. Nouailles (2023). "Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice." Viruses 15(2): 387. SYMPATH_ & CAPSyS  doi.org/10.3390/v15020387.

2022

Bahrs, C., M. Kesselmeier, M. Kolditz, S. Ewig, G. Rohde, G. Barten-Neiner, J. Rupp, M. Witzenrath, T. Welte and M. W. Pletz (2022). "A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany." European Respiratory Journal 59(2): 2102432. CAPSyS & SYMPATH_ doi.org/10.1183/13993003.02432-2021.

Bertrams, W., K. Hönzke, B. Obermayer, M. Tönnies, T. T. Bauer, P. Schneider, J. Neudecker, J. C. Rückert, T. Stiewe, A. Nist, S. Eggeling, N. Suttorp, T. Wolff, S. Hippenstiel, B. Schmeck and A. C. Hocke (2022). "Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus." Sci Rep 12(20608): 1–11. CAPSyS doi.org/10.1038/s41598-022-24792-4.

Conrad, C., D. Yildiz, S. J. Cleary, A. Margraf, L. Cook, U. Schlomann, B. Panaretou, J. L. Bowser, H. Karmouty-Quintana, J. Li, N. K. Berg, S. C. Martin, A. Aljohmani, S. F. Moussavi-Harami, K. M. Wang, J. J. Tian, M. Magnen, C. Valet, L. Qiu, J. P. Singer, H. K. Eltzschig, C. A. S. Group, W. Bertrams, S. Herold, N. Suttorp, B. Schmeck, Z. T. Ball, A. Zarbock, M. R. Looney and J. W. Bartsch (2022). "ADAM8 signaling drives neutrophil migration and ARDS severity." JCI Insight 7(3). CAPSyS www.ncbi.nlm.nih.gov/pubmed/35132956.

Dannebaum, R., P. Suwalski, H. Asgharian, G. Du Zhipei, H. Lin, J. Weiner, M. Holtgrewe, C. Thibeault, M. Müller, X. Wang, Z. Karadeniz, J. Saccomanno, J.-M. Doehn, R.-H. Hübner, B. Hinzmann, A. Blüher, S. Siemann, D. Telman, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, W. Poller, L. E. Sander, D. Beule, F. Kurth, T. Guettouche, U. Landmesser, J. Berka, K. Luong, F. Rubelt and B. Heidecker (2022). "Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19." eClinicalMedicine 48: 101438. CAPSyS & SYMPATH_ doi.org/10.1016/j.eclinm.2022.101438.

Felten, M., S. Ferencik, L.-G. T. Alves, E. Letsiou, J. Lienau, H. C. Müller-Redetzky, A. K. Langenhagen, A. Voß, K. Dietert, O. Kershaw, A. D. Gruber, L. Michalick, W. M. Kuebler, B. Ananthasubramaniam, B. Maier, H. Uhlenhaut, A. Kramer and M. Witzenrath (2022). "Ventilator-induced Lung Injury Is Modulated by the Circadian Clock." American Journal of Respiratory and Critical Care Medicine. CAPSYS doi.org/10.1164/rccm.202202-0320OC.

Hollenhorst, M. I., R. Nandigama, S. B. Evers, I. Gamayun, N. A. Wadood, A. Salah, M. Pieper, A. Wyatt, A. Stukalov, A. Gebhardt, W. Nadolni, W. Burow, C. Herr, C. Beisswenger, S. Kusumakshi, F. Ectors, T. I. Kichko, L. Hübner, P. Reeh, A. Munder, S.-M. Wienhold, M. Witzenrath, R. Bals, V. Flockerzi, T. Gudermann, M. Bischoff, P. Lipp, S. Zierler, V. Chubanov, A. Pichlmair, P. König, U. Boehm and G. Krasteva-Christ (2022). "Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection." J Clin Invest 132(13). CAPSyS & SYMPATH_ doi.org/10.1172/JCI150951.

Kheifetz, Y., H. Kirsten and M. Scholz (2022). "On the Parametrization of Epidemiologic Models—Lessons from Modelling COVID-19 Epidemic." Viruses 14(7): 1468. CAPSyS doi.org/10.3390/v14071468.

Kühnapfel, A., K. Horn, U. Klotz, M. Kiehntopf, M. Rosolowski, M. Loeffler, P. Ahnert, N. Suttorp, M. Witzenrath and M. Scholz (2022). "Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia." Genes 13(1). CAPSyS doi.org/10.3390/genes13010111.

Lask, A., B. Gutbier, O. Kershaw, G. Nouailles, A. D. Gruber, H. C. Müller-Redetzky, S. Chackowicz, D. A. Hamilton, P. Van Slyke and M. Witzenrath (2022). "Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice." Sci Rep 12(15531): 1–13. CAPSyS & SYMPATH_ doi.org/10.1038/s41598-022-19560-3.

Lingscheid, T., M. Kinzig, A. Krüger, N. Müller, G. Bölke, P. Tober-Lau, F. Münn, H. Kriedemann, M. Witzenrath, L. E. Sander, F. Sörgel and F. Kurth (2022). "Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis." Antimicrob Agents Chemother. CAPSyS & SYMPATH_ journals.asm.org/doi/10.1128/aac.01229-22.

Lingscheid, T., L. J. Lippert, D. Hillus, T. Kruis, C. Thibeault, E. T. Helbig, P. Tober-Lau, F. Pfäfflin, H. Müller-Redetzky, M. Witzenrath, T. Zoller, A. Uhrig, B. Opitz, N. Suttorp, T. S. Kramer, L. E. Sander, M. S. Stegemann and F. Kurth (2022). "Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study." Infection. CAPSyS & SYMPATH_ doi.org/10.1007/s15010-022-01796-w.

Ni, B., S. Chen, K. A. Ryan, M. L. Maitland, J. S. Farrar, M. Witzenrath, B. Gubier, C. Serdjebi, K. Bertotti, R. Wang, F. N. Salloum, L. Marino, B. D. Mitchell and F. S. Celi (2022). "Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome." Molecular Metabolism: 101588. CAPSYS & SYMPATH_ doi.org/10.1016/j.molmet.2022.101588.

Pennitz, P., H. Kirsten, V. D. Friedrich, E. Wyler, C. Goekeri, B. Obermayer, G. A. Heinz, M.-F. Mashreghi, M. Büttner, J. Trimpert, M. Landthaler, N. Suttorp, A. C. Hocke, S. Hippenstiel, M. Tönnies, M. Scholz, W. M. Kuebler, M. Witzenrath, K. Hoenzke and G. Nouailles (2022). "A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics." European Respiratory Review 31(165). CAPSyS & SYMPATH_ doi.org/10.1183/16000617.0056-2022.

Steinbeis, F., P. Knape, M. Mittermaier, E. T. Helbig, P. Tober-Lau, C. Thibeault, L. J. Lippert, W. Xiang, M. Müller-Plathe, S. Steinbrecher, H.-J. Meyer, R. M. Ring, C. Ruwwe-Glösenkamp, F. Alius, Y. Li, H. Müller-Redetzky, A. Uhrig, T. Lingscheid, D. Grund, B. Temmesfeld-Wollbrück, N. Suttorp, L. E. Sander, F. Kurth, M. Witzenrath and T. Zoller (2022). "Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents." Respiratory Medicine: 106968. CAPSyS & SYMPATH_ doi.org/10.1016/j.rmed.2022.106968.

Vlaar, A. P. J., M. Witzenrath, P. van Paassen, L. M. A. Heunks, B. Mourvillier, S. de Bruin, E. H. T. Lim, M. C. Brouwer, P. R. Tuinman, J. F. K. Saraiva, G. Marx, S. M. Lobo, R. Boldo, J. A. Simon-Campos, A. D. Cornet, A. Grebenyuk, J. M. Engelbrecht, M. Mukansi, P. G. Jorens, R. Zerbib, S. Rückinger, K. Pilz, R. Guo, D. van de Beek, N. C. Riedemann, A. P. J. Vlaar, M. Witzenrath, P. van Paassen, L. M. A. Heunks, B. Mourvillier, S. de Bruin, E. H. T. Lim, M. C. Brouwer, P. R. Tuinman, J. F. K. Saraiva, G. Marx, S. Lobo, R. Boldo, J. Simon-Campos, A. D. Cornet, A. Grebenyuk, J. Engelbrecht, M. Mukansi, P. G. Jorens, R. Zerbib, S. Rückinger, K. Pilz, R. Guo, D. van de Beek, N. C. Riedemann, P. Bulpa, F. S. Taccone, G. Hermans, M. Diltoer, M. Piagnerelli, N. De Neve, A. T. Freire, F. D. Pizzol, A. K. Marinho, V. H. Sato, C. Arns da Cunha, M. Neuville, J. Dellamonica, D. Annane, A. Roquilly, J. L. Diehl, F. Schneider, J. P. Mira, J. B. Lascarrou, L. Desmedt, C. Dupuis, C. Schwebel, G. Thiéry, M. Gründling, M. Berger, T. Welte, M. Bauer, U. Jaschinski, K. Matschke, R. Mercado-Longoria, B. Gomez Quintana, J. A. Zamudio-Lerma, J. Moreno Hoyos Abril, A. Aleman Marquez, P. Pickkers, L. Otterspoor, L. Hercilla Vásquez, C. R. Seas Ramos, A. Peña Villalobos, G. Gianella Malca, V. Chávez, V. Filimonov, V. Kulabukhov, P. Acharya, S. A. M. E. G. Timmermans, M. H. Busch, F. L. F. van Baarle, R. Koning, L. ter Horst, N. Chekrouni, T. M. van Soest, M. A. Slim, L. A. van Vught, R. B. E. van Amstel, S. E. Olie, I. E. van Zeggeren, M. C. G. van de Poll, C. Thielert and D. Neukirchen (2022). "Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial." Lancet Respiratory Medicine. CAPSYS & SYMPATH_ doi.org/10.1016/S2213-2600(22)00297-1.

Wyler, E., J. M. Adler, K. Eschke, G. Teixeira Alves, S. Peidli, F. Pott, J. Kazmierski, L. Michalick, O. Kershaw, J. Bushe, S. Andreotti, P. Pennitz, A. Abdelgawad, D. Postmus, C. Goffinet, J. Kreye, S. M. Reincke, H. Prüss, N. Blüthgen, A. D. Gruber, W. M. Kuebler, M. Witzenrath, M. Landthaler, G. Nouailles and J. Trimpert (2022). "Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics." Mol Ther 30(5): 1952–1965. CAPSyS & SYMPATH_ doi.org/10.1016/j.ymthe.2022.03.014.

2021

Bertrams, W., K. Griss, M. Han, K. Seidel, S. Hippenstiel, N. Suttorp, F. Finkernagel, J. Wilhelm, C. F. Vogelmeier and B. Schmeck (2021). "Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection." Life Sci 270: 119158. CAPSyS doi.org/10.1016/j.lfs.2021.119158.

Chillappagari, S., V. Garapati, P. Mahavadi, L. Naehrlich, B. T. Schmeck, M. L. Schmitz and A. Guenther (2021). "Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells." J. Cyst. Fibros. 20(1): 140–148. CAPSYS doi.org/10.1016/j.jcf.2020.05.006.

Demichev, V., P. Tober-Lau, O. Lemke, T. Nazarenko, C. Thibeault, H. Whitwell, A. Rohl, A. Freiwald, L. Szyrwiel, D. Ludwig, C. Correia-Melo, S. K. Aulakh, E. T. Helbig, P. Stubbemann, L. J. Lippert, N. M. Gruning, O. Blyuss, S. Vernardis, M. White, C. B. Messner, M. Joannidis, T. Sonnweber, S. J. Klein, A. Pizzini, Y. Wohlfarter, S. Sahanic, R. Hilbe, B. Schaefer, S. Wagner, M. Mittermaier, F. Machleidt, C. Garcia, C. Ruwwe-Glosenkamp, T. Lingscheid, L. Bosquillon de Jarcy, M. S. Stegemann, M. Pfeiffer, L. Jurgens, S. Denker, D. Zickler, P. Enghard, A. Zelezniak, A. Campbell, C. Hayward, D. J. Porteous, R. E. Marioni, A. Uhrig, H. Muller-Redetzky, H. Zoller, J. Loffler-Ragg, M. A. Keller, I. Tancevski, J. F. Timms, A. Zaikin, S. Hippenstiel, M. Ramharter, M. Witzenrath, N. Suttorp, K. Lilley, M. Mulleder, L. E. Sander, P.-C.-S. group, M. Ralser and F. Kurth (2021). "A time-resolved proteomic and prognostic map of COVID-19." Cell Syst 12(8): 780-794 e787. SYMPATH_ & CAPSyS www.ncbi.nlm.nih.gov/pubmed/34139154.

Doehn, J.-M., C. Tabeling, R. Biesen, J. Saccomanno, E. Madlung, E. Pappe, F. Gabriel, F. Kurth, C. Meisel, V. M. Corman, L. G. Hanitsch, S. Treskatsch, K. Heim, M. S. Stegemann, C. Ruwwe-Glösenkamp, H. C. Müller-Redetzky, A. Uhrig, R. Somasundaram, C. Spies, H. von Bernuth, J. Hofmann, C. Drosten, N. Suttorp, M. Witzenrath, L. E. Sander and R.-H. Hübner (2021). "CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity." Infection 49(4): 757–762. CAPSyS doi.org/10.1007/s15010-021-01606-9.

Hadzibegovic, S., A. Lena, T. W. Churchill, J. E. Ho, S. Potthoff, C. Denecke, L. Rösnick, K. M. Heim, M. Kleinschmidt, L. E. Sander, M. Witzenrath, N. Suttorp, A. Krannich, J. Porthun, T. Friede, J. Butler, U. Wilkenshoff, B. Pieske, U. Landmesser, S. D. Anker, G. D. Lewis, C. Tschöpe and M. S. Anker (2021). "Heart Failure with preserved ejection fraction according to the HFA‐PEFF score in COVID‐19 patients: clinical correlates and echocardiographic findings." European Journal of Heart Failure. CAPSyS & SYMPATH_ doi.org/10.1002/ejhf.2210.

Jagdmann, S., D. Berchtold, B. Gutbier, M. Witzenrath, A. Meisel, C. Meisel and C. Dames (2021). "Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections." Journal of Neuroimmunology 355: 577568. CAPSyS & SYMPATH_ doi.org/10.1016/j.jneuroim.2021.577568.

Jung, A. L., B. Schmeck, M. Wiegand, K. Bedenbender and B. J. Benedikter (2021). "The clinical role of host and bacterial-derived extracellular vesicles in pneumonia." Adv Drug Delivery Rev 176: 113811. CAPSyS doi.org/10.1016/j.addr.2021.05.021.

Letsiou, E., L. G. Teixeira Alves, D. Fatykhova, M. Felten, T. J. Mitchell, H. C. Müller-Redetzky, A. C. Hocke and M. Witzenrath (2021). "Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst - Scientific Reports." Sci Rep 11(9529): 1–13. CAPSyS & SYMPATH_ doi.org/10.1038/s41598-021-88897-y.

Letsiou, E., L. G. Teixeira Alves, M. Felten, T. J. Mitchell, H. C. Müller-Redetzky, S. M. Dudek and M. Witzenrath (2021). "Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure." Cells 10(12): 3581. CAPSyS & SYMPATH_ doi.org/10.3390/cells10123581.

Linden, G., H. Janga, M. Franz, A. Nist, T. Stiewe, B. Schmeck, O. Vázquez and L. N. Schulte (2021). "Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes." RNA Biol.: 1–15. CAPSys doi.org/10.1080/15476286.2021.1885209.

Messner, C. B., V. Demichev, N. Bloomfield, J. S. L. Yu, M. White, M. Kreidl, A.-S. Egger, A. Freiwald, G. Ivosev, F. Wasim, A. Zelezniak, L. Jürgens, N. Suttorp, L. E. Sander, F. Kurth, K. S. Lilley, M. Mülleder, S. Tate and M. Ralser (2021). "Ultra-fast proteomics with Scanning SWATH." Nat. Biotechnol. 39(7): 846-854. CAPSyS doi.org/10.1038/s41587-021-00860-4.

Michalick, L., S. Weidenfeld, B. Grimmer, D. Fatykhova, P. D. Solymosi, F. Behrens, M. Dohmen, M. C. Brack, S. Schulz, E. Thomasch, S. Simmons, H. Müller-Redetzky, N. Suttorp, F. Kurth, J. Neudecker, M. Toennies, T. T. Bauer, S. Eggeling, V. M. Corman, A. C. Hocke, M. Witzenrath, S. Hippenstiel and W. M. Kuebler (2021). "Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure." European Respiratory Journal 57(3). CAPSyS & SYMPATH_ doi.org/10.1183/13993003.02384-2020.

Nouailles, G., E. Wyler, P. Pennitz, D. Postmus, D. Vladimirova, J. Kazmierski, F. Pott, K. Dietert, M. Muelleder, V. Farztdinov, B. Obermayer, S.-M. Wienhold, S. Andreotti, T. Hoefler, B. Sawitzki, C. Drosten, L. E. Sander, N. Suttorp, M. Ralser, D. Beule, A. D. Gruber, C. Goffinet, M. Landthaler, J. Trimpert and M. Witzenrath (2021). "Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19." Nat Commun 12. CAPSyS & SYMPATH_ doi.org/10.1038/s41467-021-25030-7.

Ochs, M., S. Timm, S. Elezkurtaj, D. Horst, J. Meinhardt, F. L. Heppner, S. Weber-Carstens, A. C. Hocke and M. Witzenrath (2021). "Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient." European Respiratory Journal 57(5). CAPSyS & SYMPATH_ doi.org/10.1183/13993003.04165-2020.

Roessler, F. K., B. J. Benedikter, B. Schmeck and N. Bar (2021). "Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samples - Scientific Reports." Sci Rep 11(10258): 1–13. CAPSyS doi.org/10.1038/s41598-021-89762-8.

Tabeling, C., S.-M. Wienhold, A. Birnhuber, M. C. Brack, G. Nouailles, O. Kershaw, T. C. Firsching, A. D. Gruber, J. Lienau, L. M. Marsh, A. Olschewski, G. Kwapiszewska and M. Witzenrath (2021). "Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia." American Journal of Physiology-Lung Cellular and Molecular Physiology. CAPSyS doi.org/10.1152/ajplung.00505.2020.

Vera, J., C. Lischer, M. Nenov, S. Nikolov, X. Lai and M. Eberhardt (2021). "Mathematical Modelling in Biomedicine: A Primer for the Curious and the Skeptic." Int J Mol Sci 22(2): 547. CAPSYS & MelAutim doi.org/10.3390/ijms22020547.

Weiner, J., P. Suwalski, M. Holtgrewe, A. Rakitko, C. Thibeault, M. Müller, D. Patriki, C. Quedenau, U. Krüger, V. Ilinsky, I. Popov, J. Balnis, A. Jaitovich, E. T. Helbig, L. J. Lippert, P. Stubbemann, L. M. Real, J. Macías, J. A. Pineda, M. Fernandez-Fuertes, X. Wang, Z. Karadeniz, J. Saccomanno, J.-M. Doehn, R.-H. Hübner, B. Hinzmann, M. Salvo, A. Blueher, S. Siemann, S. Jurisic, J. H. Beer, J. Rutishauser, B. Wiggli, H. Schmid, K. Danninger, R. Binder, V. M. Corman, B. Mühlemann, R. Arjun Arkal, G. K. Fragiadakis, E. Mick, C. COMET, C. S. Calfee, D. J. Erle, C. M. Hendrickson, K. N. Kangelaris, M. F. Krummel, P. G. Woodruff, C. R. Langelier, U. Venkataramani, F. García, J. Zyla, C. Drosten, B. Alice, T. C. Jones, N. Suttorp, M. Witzenrath, S. Hippenstiel, T. Zemojtel, C. Skurk, W. Poller, T. Borodina, S. G. Pa-COVID, S. Ripke, L. E. Sander, D. Beule, U. Landmesser, T. Guettouche, F. Kurth and B. Heidecker (2021). "Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01." EClinicalMedicine 40: 101099. CAPSyS & SYMPATH_ doi.org/10.1016/j.eclinm.2021.101099.

Wendisch, D., O. Dietrich, T. Mari, S. von Stillfried, I. L. Ibarra, M. Mittermaier, C. Mache, R. L. Chua, R. Knoll, S. Timm, S. Brumhard, T. Krammer, H. Zauber, A. L. Hiller, A. Pascual-Reguant, R. Mothes, R. D. Bulow, J. Schulze, A. M. Leipold, S. Djudjaj, F. Erhard, R. Geffers, F. Pott, J. Kazmierski, J. Radke, P. Pergantis, K. Bassler, C. Conrad, A. C. Aschenbrenner, B. Sawitzki, M. Landthaler, E. Wyler, D. Horst, C.-O. I. Deutsche, S. Hippenstiel, A. Hocke, F. L. Heppner, A. Uhrig, C. Garcia, F. Machleidt, S. Herold, S. Elezkurtaj, C. Thibeault, M. Witzenrath, C. Cochain, N. Suttorp, C. Drosten, C. Goffinet, F. Kurth, J. L. Schultze, H. Radbruch, M. Ochs, R. Eils, H. Muller-Redetzky, A. E. Hauser, M. D. Luecken, F. J. Theis, C. Conrad, T. Wolff, P. Boor, M. Selbach, A. E. Saliba and L. E. Sander (2021). "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis." Cell 184(26): 6243-6261 e6227. CAPSyS www.ncbi.nlm.nih.gov/pubmed/34914922.

Wienhold, S. M., M. C. Brack, G. Nouailles, G. Krishnamoorthy, I. H. E. Korf, C. Seitz, S. Wienecke, K. Dietert, C. Gurtner, O. Kershaw, A. D. Gruber, A. Ross, H. Ziehr, M. Rohde, J. Neudecker, J. Lienau, N. Suttorp, S. Hippenstiel, A. C. Hocke, C. Rohde and M. Witzenrath (2021). "Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection." Viruses 14(1). CAPSyS & SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/35062236.

Witzenrath, M. and W. M. Kuebler (2021). "The CypA-netics of Ventilator-induced Lung Injury." Am J Respir Crit Care Med 204(4): 385-387. CAPSyS & SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34033522.

2020

Aznaourova, M., H. Janga, S. Sefried, A. Kaufmann, J. Dorna, S. M. Volkers, P. Georg, M. Lechner, J. Hoppe, S. Dökel, N. Schmerer, A. D. Gruber, U. Linne, S. Bauer, L. E. Sander, B. Schmeck and L. N. Schulte (2020). "Noncoding RNA MaIL1 is an integral component of the TLR4–TRIF pathway." Proc Natl Acad Sci U.S.A: 201920393. CAPSyS doi.org/10.1073/pnas.1920393117.

Bertrams, W., K. Griss, M. Han, K. Seidel, A. Klemmer, A. Sittka-Stark, S. Hippenstiel, N. Suttorp, F. Finkernagel, J. Wilhelm, T. Greulich, C. F. Vogelmeier, J. Vera and B. Schmeck (2020). "Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation." Sci Rep 10(1): 241. CAPSyS doi.org/10.1038/s41598-019-57108-0.

Braun, J., L. Loyal, M. Frentsch, D. Wendisch, P. Georg, F. Kurth, S. Hippenstiel, M. Dingeldey, B. Kruse, F. Fauchere, E. Baysal, M. Mangold, L. Henze, R. Lauster, M. A. Mall, K. Beyer, J. Röhmel, S. Voigt, J. Schmitz, S. Miltenyi, I. Demuth, M. A. Müller, A. Hocke, M. Witzenrath, N. Suttorp, F. Kern, U. Reimer, H. Wenschuh, C. Drosten, V. M. Corman, C. Giesecke-Thiel, L. E. Sander and A. Thiel (2020). "SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19." Nature: 1–8. CAPSyS doi.org/10.1038/s41586-020-2598-9.

Chua, R. L., S. Lukassen, S. Trump, B. P. Hennig, D. Wendisch, F. Pott, O. Debnath, L. Thürmann, F. Kurth, M. T. Völker, J. Kazmierski, B. Timmermann, S. Twardziok, S. Schneider, F. Machleidt, H. Müller-Redetzky, M. Maier, A. Krannich, S. Schmidt, F. Balzer, J. Liebig, J. Loske, N. Suttorp, J. Eils, N. Ishaque, U. G. Liebert, C. von Kalle, A. Hocke, M. Witzenrath, C. Goffinet, C. Drosten, S. Laudi, I. Lehmann, C. Conrad, L.-E. Sander and R. Eils (2020). "COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis." Nat Biotechnol: 1–10. CAPSyS doi.org/10.1038/s41587-020-0602-4.

Herkt, C. E., B. E. Caffrey, K. Surmann, S. Blankenburg, M. G. Salazar, A. L. Jung, S. M. Herbel, K. Hoffmann, L. N. Schulte, W. Chen, A. Sittka-Stark, U. Voelker, M. Vingron, A. Marsico, W. Bertrams and B. Schmeck (2020). "A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1." MBIO 11(2). CAPSyS doi.org/10.1128/mBio.03155-19.

Hübner, K., D. Karwelat, E. Pietsch, I. Beinborn, S. Winterberg, K. Bedenbender, B. J. Benedikter, B. Schmeck and E. Vollmeister (2020). "NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells." Cell. Signalling 67: 109498. CAPSyS doi.org/10.1016/j.cellsig.2019.109498.

Jung, A. L., M. M. Jorgensen, R. Baek, K. Griss, M. Han, K. A. D. Brinke, N. Timmesfeld, W. Bertrams, T. Greulich, R. Koczulla, S. Hippenstiel, N. Suttorp and B. Schmeck (2020). "Surface Proteome of Plasma Extracellular Vesicles as Biomarkers for Pneumonia and Acute Exacerbation of Chronic Obstructive Pulmonary Disease." J Infect Dis 221(2): 325–335. CAPSyS doi.org/10.1093/infdis/jiz460.

Karwelat, D., B. Schmeck, M. Ringel, B. J. Benedikter, K. Huebner, I. Beinborn, A. Maisner, L. N. Schulte and E. Vollmeister (2020). "Influenza virus-mediated suppression of bronchial Chitinase-3-like 1 secretion promotes secondary pneumococcal infection." FASEB J. CAPSyS doi.org/10.1096/fj.201902988RR.

Korfhage, N., M. Mühling, S. Ringshandl, A. Becker, B. Schmeck and B. Freisleben (2020). "Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion." PLoS Comput Biol 16(9): e1008179. CAPSyS doi.org/10.1371/journal.pcbi.1008179.

Messner, C. B., V. Demichev, D. Wendisch, L. Michalick, M. White, A. Freiwald, K. Textoris-Taube, S. Vernardis, A.-S. Egger, M. Kreidl, D. Ludwig, C. Kilian, F. Agostini, A. Zelezniak, C. Thibeault, M. Pfeiffer, S. Hippenstiel, A. Hocke, C. von Kalle, A. Campbell, C. Hayward, D. J. Porteous, R. E. Marioni, C. Langenberg and K. S. Lilley (2020). "Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection." CELL SYSTEMS 11(1): 11–+. CAPSyS & SYMPATH_ doi.org/10.1016/j.cels.2020.05.012.

Mikolajewska, A. and M. Witzenrath (2020). "Ambulant erworbene Pneumonie bei Erwachsenen." Dtsch med Wochenschr 145(06): 359–370. CAPSyS doi.org/10.1055/a-0993-0874.

Mittermaier, M., P. Pickerodt, F. Kurth, L. B. de Jarcy, A. Uhrig, C. Garcia, F. Machleidt, P. Pergantis, S. Weber, Y. Li, A. Breitbart, F. Bremer, P. Knape, M. Dewey, F. Doellinger, S. Weber-Carstens, A. S. Slutsky, W. M. Kuebler, N. Suttorp and H. Müller-Redetzky (2020). "Evaluation of PEEP and prone positioning in early COVID-19 ARDS." EClinicalMedicine 28: 100579. SYMPATH_ & CAPSyS doi.org/10.1016/j.eclinm.2020.100579.

Mueller-Redetzky, H., U. Kellermann, S.-M. Wienhold, B. Gutbier, J. Lienau, K. Hellwig, K. Reppe, E. Letsiou, T. Tschernig, M. Scholz, P. Ahnert, C. Maasch, K. Hoehlig, S. Klussmann, A. Vater, T. C. Firsching, J. Hoppe, N. Suttorp and M. Witzenrath (2020). "Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis." ANESTHESIOLOGY 132(4): 795–807. CAPSyS doi.org/10.1097/ALN.0000000000003149.

Nikoghosyan, M., M. Schmidt, K. Margaryan, H. Loeffler-Wirth, A. Arakelyan and H. Binder (2020). "SOMmelier-Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks." GENES 11(7). CAPSyS doi.org/10.3390/genes11070817.

Ochs, M., J. Hegermann, E. Lopez-Rodriguez, S. Timm, G. Nouailles, J. Matuszak, S. Simmons, M. Witzenrath and W. M. Kuebler (2020). "On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx." Int J Mol Sci 21(9). CAPSyS doi.org/10.3390/ijms21093075.

Przybilla, J., P. Ahnert, H. Bogatsch, F. Bloos, F. M. Brunkhorst, M. Bauer, M. Loeffler, M. Witzenrath, N. Suttorp and M. Scholz (2020). "Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia." JOURNAL OF CLINICAL MEDICINE 9(2). CAPSyS doi.org/10.3390/jcm9020393.

Sanapala, S. R., B. M. S. Seco, J. Y. Baek, S. Awan, C. L. Pereira and P. H. Seeberger (2020). "Chimeric oligosaccharide conjugate induces opsonic antibodies againstStreptococcus pneumoniaeserotypes 19A and 19F." Chem Sci 11(28): 7401–7407. CAPSyS doi.org/10.1039/d0sc02230f.

Santos, G. and J. Vera (2020). "The Role of Age, Neutrophil Infiltration and Antibiotics Timing in the Severity of Streptococcus pneumoniae Pneumonia. Insights from a Multi-Level Mathematical Model Approach." Int J Mol Sci 21(22): 8428. CAPSyS doi.org/10.3390/ijms21228428.

Schirm, S., P. Ahnert, S. Berger, G. Nouailles, S.-M. Wienhold, H. Müller-Redetzky, N. Suttorp, M. Loeffler, M. Witzenrath and M. Scholz (2020). "A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection." PLoS One 15(12): e0243147. CAPSyS & SYMPATH_ doi.org/10.1371/journal.pone.0243147.

Schmidt, M., L. Hopp, A. Arakelyan, H. Kirsten, C. Engel, K. Wirkner, K. Krohn, R. Burkhardt, J. Thiery, M. Loeffler, H. Loeffler-Wirth and H. Binder (2020). "The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health." Front Big Data 3. CAPSyS doi.org/10.3389/fdata.2020.548873.

Thalheim, T., L. Hopp, M. Herberg, S. Siebert, C. Kerner, M. Quaas, M. R. Schweiger, G. Aust and J. Galle (2020). "Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells." Int J Mol Sci 21(6). CAPSyS doi.org/10.3390/ijms21061941.

2019

Blankenburg, S., Hentschker, C., Nagel, A., Hildebrandt, P., Michalik, S., Dittmar, D., Surmann, K. and Volker, U. (2019). "Improving Proteome Coverage for Small Sample Amounts: An Advanced Method for Proteomics Approaches with Low Bacterial Cell Numbers." Proteomics 19(23): e1900192. www.ncbi.nlm.nih.gov/pubmed/31532911.

Brack, M. C., Lienau, J., Kuebler, W. M. and Witzenrath, M. (2019). "Cardiovascular sequelae of pneumonia." Curr Opin Pulm Med 25(3): 257-262. www.ncbi.nlm.nih.gov/pubmed/30893107.

Dabrowski, A. N., Shrivastav, A., Conrad, C., Komma, K., Weigel, M., Dietert, K., Gruber, A. D., Bertrams, W., Wilhelm, J., Schmeck, B., Reppe, K., N'Guessan, P. D., Aly, S., Suttorp, N., Hain, T. and Zahlten, J. (2019). "Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and Inflammation in Lungs by Control of the Gut Microbiota." Front Immunol 10: 2106. www.ncbi.nlm.nih.gov/pubmed/31616404.

Franssen, F. M., Alter, P., Bar, N., Benedikter, B. J., Iurato, S., Maier, D., Maxheim, M., Roessler, F. K., Spruit, M. A., Vogelmeier, C. F., Wouters, E. F. and Schmeck, B. (2019). "Personalized medicine for patients with COPD: where are we?" Int J Chron Obstruct Pulmon Dis 14: 1465-1484. www.ncbi.nlm.nih.gov/pubmed/31371934.

Jensen, A. V., Baunbaek Egelund, G., Bang Andersen, S., Petersen, P. T., Benfield, T., Witzenrath, M., Rohde, G., Ravn, P., Faurholt-Jepsen, D. and Members of the, C. s. g. e. t. a. (2019). "The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia. A Prospective Cohort Study." Ann Am Thorac Soc 16(12): 1518-1526. www.ncbi.nlm.nih.gov/pubmed/31437014.

Limburg, H., Harbig, A., Bestle, D., Stein, D. A., Moulton, H. M., Jaeger, J., Janga, H., Hardes, K., Koepke, J., Schulte, L., Koczulla, A. R., Schmeck, B., Klenk, H. D. and Bottcher-Friebertshauser, E. (2019). "TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes." J Virol. www.ncbi.nlm.nih.gov/pubmed/31391268.

Lindhauer, N. S., Bertrams, W., Poppel, A., Herkt, C. E., Wesener, A., Hoffmann, K., Greene, B., Van Der Linden, M., Vilcinskas, A., Seidel, K. and Schmeck, B. (2019). "Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae." Virulence 10(1): 902-909. www.ncbi.nlm.nih.gov/pubmed/31657264.

Loeffler-Wirth, H., Kreuz, M., Hopp, L., Arakelyan, A., Haake, A., Cogliatti, S. B., Feller, A. C., Hansmann, M. L., Lenze, D., Moller, P., Muller-Hermelink, H. K., Fortenbacher, E., Willscher, E., Ott, G., Rosenwald, A., Pott, C., Schwaenen, C., Trautmann, H., Wessendorf, S., Stein, H., Szczepanowski, M., Trumper, L., Hummel, M., Klapper, W., Siebert, R., Loeffler, M., Binder, H. and German Cancer Aid consortium Molecular Mechanisms for Malignant, L. (2019). "A modular transcriptome map of mature B cell lymphomas." Genome Med 11(1): 27. www.ncbi.nlm.nih.gov/pubmed/31039827.

Lückel, C., Picard, F., Raifer, H., Carrascosa, L. C., Guralnik, A., Zhang, Y., Klein, M., Bittner, S., Steffen, F., Moos, S., Marini, F., Gloury, R., Kurschus, F. C., Chao, Y.-Y., Bertrams, W., Sexl, V., Schmeck, B., Bonetti, L., Grusdat, M., Lohoff, M., Zielinski, C. E., Zipp, F., Kallies, A., Brenner, D., Berger, M., Bopp, T., Tackenberg, B. and Huber, M. (2019). "IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis." Nat Commun 10(1): 1--15. www.nature.com/articles/s41467-019-13731-z.

Nikoghosyan, M., Hakobyan, S., Hovhannisyan, A., Loeffler-Wirth, H., Binder, H. and Arakelyan, A. (2019). "Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians - A Machine Learning Approach." Front Genet 10: 394. www.ncbi.nlm.nih.gov/pubmed/31105750.

Regier, Y., Komma, K., Weigel, M., Kraiczy, P., Laisi, A., Pulliainen, A. T., Hain, T. and Kempf, V. A. J. (2019). "Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany." Parasites & Vectors 12(1): 11. www.ncbi.nlm.nih.gov/pubmed/30616666.

Scheller, N., Herold, S., Kellner, R., Bertrams, W., Jung, A. L., Janga, H., Greulich, T., Schulte, L. N., Vogelmeier, C. F., Lohmeyer, J. and Schmeck, B. (2019). "Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome." J Infect Dis 219(4): 540-543. www.ncbi.nlm.nih.gov/pubmed/30239899.

Schulte, L. N., Bertrams, W., Stielow, C. and Schmeck, B. (2019). "ncRNAs in Inflammatory and Infectious Diseases." Methods Mol Biol 1912: 3-32. www.ncbi.nlm.nih.gov/pubmed/30635888.

Wienhold, S. M., Lienau, J. and Witzenrath, M. (2019). "Towards Inhaled Phage Therapy in Western Europe." Viruses 11(3). www.ncbi.nlm.nih.gov/pubmed/30909579.

2018

Berger, S., Goekeri, C., Gupta, S. K., Vera, J., Dietert, K., Behrendt, U., Lienau, J., Wienhold, S.-M., Gruber, A. D., Suttorp, N., Witzenrath, M. and Nouailles, G. (2018). "Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia." Critical Care (London, England) 22(1): 287. www.ncbi.nlm.nih.gov/pubmed/30382866.

Dietert, K., Nouailles, G., Gutbier, B., Reppe, K., Berger, S., Jiang, X., Schauer, A. E., Hocke, A. C., Herold, S., Slevogt, H., Witzenrath, M., Suttorp, N. and Gruber, A. D. (2018). "Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia." American Journal of Respiratory Cell and Molecular Biology 58(4): 440-448. www.ncbi.nlm.nih.gov/pubmed/29361238.

Gutbier, B., Neuhauß, A.-K., Reppe, K., Ehrler, C., Santel, A., Kaufmann, J., Scholz, M., Weissmann, N., Morawietz, L., Mitchell, T. J., Aliberti, S., Hippenstiel, S., Suttorp, N., Witzenrath, M., Capnetz and ‡, P. S. G. (2018). "Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia." American Journal of Respiratory and Critical Care Medicine 198(2): 220-231. www.ncbi.nlm.nih.gov/pubmed/29447449.

Gutbier, B., Schönrock, S. M., Ehrler, C., Haberberger, R., Dietert, K., Gruber, A. D., Kummer, W., Michalick, L., Kuebler, W. M., Hocke, A. C., Szymanski, K., Letsiou, E., Lüth, A., Schumacher, F., Kleuser, B., Mitchell, T. J., Bertrams, W., Schmeck, B., Treue, D., Klauschen, F., Bauer, T. T., Tönnies, M., Weissmann, N., Hippenstiel, S., Suttorp, N., Witzenrath, M. and Group, C. S. (2018). "Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2." Critical Care Medicine. www.ncbi.nlm.nih.gov/pubmed/29298188.

Hopp, L., Loeffler-Wirth, H., Nersisyan, L., Arakelyan, A. and Binder, H. (2018). "Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome." Frontiers in Immunology 9: 1620. www.ncbi.nlm.nih.gov/pubmed/30065722.

Kaplonek, P., Khan, N., Reppe, K., Schumann, B., Emmadi, M., Lisboa, M. P., Xu, F.-F., Calow, A. D. J., Parameswarappa, S. G., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2018). "Improving vaccines against Streptococcus pneumoniae using synthetic glycans." Proceedings of the National Academy of Sciences of the United States of America 115(52): 13353-13358. www.ncbi.nlm.nih.gov/pubmed/30530654.

Marin-Sanguino, A., Vera, J. and Alves, R. (2018). "Editorial: Foundations of Theoretical Approaches in Systems Biology." Frontiers in Genetics 9: 290.

Regier, Y., Komma, K., Weigel, M., Pulliainen, A. T., Goettig, S., Hein, T. and Kempf, V. A. J. (2018). "Microbiome Analysis Reveals the Presence of Bartonella spp. and Acinetobacter spp. in Deer Keds (Lipoptena cervi)." Frontiers in Microbiology 9: 3100. www.ncbi.nlm.nih.gov/pubmed/30619179.

Ruiz-Moreno, J. S., Hamann, L., Jin, L., Sander, L. E., Puzianowska-Kuznicka, M., Cambier, J., Witzenrath, M., Schumann, R. R., Suttorp, N. and Opitz, B. (2018). "The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans." Infection and Immunity 86(3). www.ncbi.nlm.nih.gov/pubmed/29263110.

Ruiz-Moreno, J. S., Hamann, L., Shah, J. A., Verbon, A., Mockenhaupt, F. P., Puzianowska-Kuznicka, M., Naujoks, J., Sander, L. E., Witzenrath, M., Cambier, J. C., Suttorp, N., Schumann, R. R., Jin, L., Hawn, T. R., Opitz, B. and Group, C. S. (2018). "The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans." PLoS pathogens 14(1): e1006829. www.ncbi.nlm.nih.gov/pubmed/29298342.

Santos, G., Lai, X., Eberhardt, M. and Vera, J. (2018). "Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling." Frontiers in Cellular and Infection Microbiology 8. www.ncbi.nlm.nih.gov/pubmed/29868515.

Schumann, B., Reppe, K., Kaplonek, P., Wahlbrink, A., Anish, C., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2018). "Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1." ACS central science 4(3): 357-361. www.ncbi.nlm.nih.gov/pubmed/29632881.

Vera, J. and Santos, G. (2018). "Can Gamification Contribute to Computer Modeling-Driven Biomedical Research?" Frontiers in Physiology 9: 908. www.ncbi.nlm.nih.gov/pubmed/30072911.

Wienhold, S.-M., Macrì, M., Nouailles, G., Dietert, K., Gurtner, C., Gruber, A. D., Heimesaat, M. M., Lienau, J., Schumacher, F., Kleuser, B., Opitz, B., Suttorp, N., Witzenrath, M. and Müller-Redetzky, H. C. (2018). "Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice." Critical Care (London, England) 22(1): 282. www.ncbi.nlm.nih.gov/pubmed/30373626.

2017

Arakelyan, A., Nersisyan, L., Poghosyan, D., Khondkaryan, L., Hakobyan, A., Löffler-Wirth, H., Melanitou, E. and Binder, H. (2017). "Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles." PloS One 12(11): e0187572. www.ncbi.nlm.nih.gov/pubmed/29099860.

Cantone, M., Santos, G., Wentker, P., Lai, X. and Vera, J. (2017). "Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection." Frontiers in Physiology 8: 645. www.ncbi.nlm.nih.gov/pubmed/28912729.

Emmadi, M., Khan, N., Lykke, L., Reppe, K., G Parameswarappa, S., Lisboa, M. P., Wienhold, S.-M., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2017). "A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease." Journal of the American Chemical Society 139(41): 14783-14791. www.ncbi.nlm.nih.gov/pubmed/28945368.

Gutbier, B., Jiang, X., Dietert, K., Ehrler, C., Lienau, J., Van Slyke, P., Kim, H., Hoang, V. C., Maynes, J. T., Dumont, D. J., Gruber, A. D., Weissmann, N., Mitchell, T. J., Suttorp, N. and Witzenrath, M. (2017). "Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia." Critical Care (London, England) 21(1): 274. www.ncbi.nlm.nih.gov/pubmed/29132435.

Jensen, A. V., Faurholt-Jepsen, D., Egelund, G. B., Andersen, S. B., Petersen, P. T., Benfield, T., Witzenrath, M., Rohde, G., Ravn, P., German Community-Acquired Pneumonia Competence, N. and German Community-Acquired Pneumonia Competence, N. (2017). "Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study." Clinical Infectious Diseases 65(12): 2091-2098. www.ncbi.nlm.nih.gov/pubmed/29095981.

Jentho, E., Bodden, M., Schulz, C., Jung, A.-L., Seidel, K., Schmeck, B. and Bertrams, W. (2017). "microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1." PloS One 12(4): e0176204. www.ncbi.nlm.nih.gov/pubmed/28445535.

Jung, A. L., Herkt, C. E., Schulz, C., Bolte, K., Seidel, K., Scheller, N., Sittka-Stark, A., Bertrams, W. and Schmeck, B. (2017). "Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles." Scientific Reports 7(1): 6301. www.ncbi.nlm.nih.gov/pubmed/28740179.

Jung, A. L., Hoffmann, K., Herkt, C. E., Schulz, C., Bertrams, W. and Schmeck, B. (2017). "Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages." Journal of Visualized Experiments: JoVE(120). www.ncbi.nlm.nih.gov/pubmed/28287548.

Lisboa, M. P., Khan, N., Martin, C., Xu, F.-F., Reppe, K., Geissner, A., Govindan, S., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2017). "Semisynthetic glycoconjugate vaccine candidate againstStreptococcus pneumoniaeserotype 5." Proceedings of the National Academy of Sciences of the United States of America 114(42): 11063-11068. www.ncbi.nlm.nih.gov/pubmed/28973947.

Schulz, C., Lai, X., Bertrams, W., Jung, A. L., Sittka-Stark, A., Herkt, C. E., Janga, H., Zscheppang, K., Stielow, C., Schulte, L., Hippenstiel, S., Vera, J. and Schmeck, B. (2017). "THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study." Scientific Reports 7(1): 11988. www.ncbi.nlm.nih.gov/pubmed/28931863.

Schumann, B., Hahm, H. S., Parameswarappa, S. G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L.-A., Witzenrath, M., Anish, C., Pereira, C. L. and Seeberger, P. H. (2017). "A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine." Science Translational Medicine 9(380). www.ncbi.nlm.nih.gov/pubmed/28275152.

Seeberger, P. H., Pereira, C. L., Khan, N., Xiao, G., Diago-Navarro, E., Reppe, K., Opitz, B., Fries, B. C. and Witzenrath, M. (2017). "A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae." Angewandte Chemie (International Ed. in English) 56(45): 13973-13978. www.ncbi.nlm.nih.gov/pubmed/28815890.

Wentker, P., Eberhardt, M., Dreyer, F. S., Bertrams, W., Cantone, M., Griss, K., Schmeck, B. and Vera, J. (2017). "An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data." Journal of Immunology (Baltimore, Md.: 1950) 198(5): 2191-2201. www.ncbi.nlm.nih.gov/pubmed/28137890.

2016

Arakelyan, A., Nersisyan, L., Petrek, M., Löffler-Wirth, H., Binder, H., 2016. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet 7, 79. doi.org/10.3389/fgene.2016.00079

Du Bois, I., Marsico, A., Bertrams, W., Schweiger, M.R., Caffrey, B.E., Sittka-Stark, A., Eberhardt, M., Vera, J., Vingron, M., Schmeck, B.T., 2016. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J. Infect. Dis. 214, 454–463. doi.org/10.1093/infdis/jiw171

Eberhardt, M., Lai, X., Tomar, N., Gupta, S., Schmeck, B., Steinkasserer, A., Schuler, G., Vera, J., 2016. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol. Biol. 1386, 135–179. doi.org/10.1007/978-1-4939-3283-2_9

Garn, H., Bahn, S., Baune, B.T., Binder, E.B., Bisgaard, H., Chatila, T.A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Müller-Ladner, U., Neurath, M.F., Preissner, K.T., Reinhardt, C., Rook, G., Russell, S., Schmeck, B., Stappenbeck, T., Steinhoff, U., van Os, J., Weiss, S., Zemlin, M., Renz, H., 2016. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J. Allergy Clin. Immunol. 138, 47–56. doi.org/10.1016/j.jaci.2016.02.046

Griss, K., Bertrams, W., Sittka-Stark, A., Seidel, K., Stielow, C., Hippenstiel, S., Suttorp, N., Eberhardt, M., Wilhelm, J., Vera, J., Schmeck, B., 2016. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J. Infect. Dis. 214, 288–299. doi.org/10.1093/infdis/jiw109

Jung, A.L., Stoiber, C., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2016. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 12, e1005592. doi.org/10.1371/journal.ppat.1005592

Kirschner, F., Reppe, K., Andresen, N., Witzenrath, M., Ebstein, F., Kloetzel, P.-M., 2016. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS ONE 11, e0153847. https://doi.org/10.1371/journal.pone.0153847

Lienau, J., Müller-Redetzky, H., Suttorp, N., Witzenrath, M., 2016. [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia]. Pneumologie 70, 372–378. doi.org/10.1055/s-0035-1563788

Lai, X., Wolkenhauer, O., Vera, J., 2016. Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res. 44, 6019–6035. doi.org/10.1093/nar/gkw550

Parameswarappa, S.G., Reppe, K., Geissner, A., Ménová, P., Govindan, S., Calow, A.D.J., Wahlbrink, A., Weishaupt, M.W., Monnanda, B.P., Bell, R.L., Pirofski, L.-A., Suttorp, N., Sander, L.E., Witzenrath, M., Pereira, C.L., Anish, C., Seeberger, P.H., 2016. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection. Cell Chem Biol 23, 1407–1416. doi.org/10.1016/j.chembiol.2016.09.016

Santos, G., Nikolov, S., Lai, X., Eberhardt, M., Dreyer, F.S., Paul, S., Schuler, G., Vera, J., 2016. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis. Sci Rep 6, 24967. doi.org/10.1038/srep24967

Schirm, S., Ahnert, P., Wienhold, S., Mueller-Redetzky, H., Nouailles-Kursar, G., Loeffler, M., Witzenrath, M., Scholz, M., 2016. A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice. PLoS ONE 11, e0156047. doi.org/10.1371/journal.pone.0156047

Schmeck, B., Bertrams, W., Lai, X., Vera, J., 2016. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol. Biol. 1386, 119–133. https://doi.org/10.1007/978-1-4939-3283-2_8

2015

Müller-Redetzky, H., Lienau, J., Suttorp, N., Witzenrath, M., 2015. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev 24, 516–524. doi.org/10.1183/16000617.0034-2015

Reppe, K., Radünzel, P., Dietert, K., Tschernig, T., Wolff, T., Hammerschmidt, S., Gruber, A.D., Suttorp, N., Witzenrath, M., 2015. Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. Infect. Immun. 83, 4617–4629. https://doi.org/10.1128/IAI.00948-15

2014

Witzenrath, M., 2014. Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff! Am. J. Respir. Crit. Care Med. 189, 1452–1455. doi.org/10.1164/rccm.201405-0827ED

 

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