Multiscale HCC



Frey, N., Venturelli, S., Zender, L.Bitzer, M., 2018. Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics. Nat Rev Gastroenterol Hepatol, 15(2), 81-95.

Mohr, C., Friedrich, A., Wojnar, D., Kenar, E., Polatkan, A. C., Codrea, M. C., Czemmel, S., Kohlbacher, O.Nahnsen, S., 2018. qPortal: A platform for data-driven biomedical research. PLoS ONE, 13(1), e0191603.

Seehawer, M., Heinzmann, F., D'Artista, L., Harbig, J., Roux, P.-F., Hoenicke, L., Dang, H., Klotz, S., Robinson, L., Doré, G., Rozenblum, N., Kang, T.-W., Chawla, R., Buch, T., Vucur, M., Roth, M., Zuber, J., Luedde, T., Sipos, B., Longerich, T., Heikenwälder, M., Wang, X. W., Bischof, O.Zender, L., 2018. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature.

Thaiss, W. M., Haberland, U., Kaufmann, S., Hepp, T., Schulze, M., Blum, A. C., Ketelsen, D., Nikolaou, K., Horger, M.Sauter, A. W., 2018. Dose Optimization of Perfusion-derived Response Assessment in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: Comparison of Volume Perfusion CT and Iodine Concentration. Academic Radiology.



Kurucay, M., Kloth, C., Kaufmann, S., Nikolaou, K., Bösmüller, H., Horger, M., Thaiss, W.M., 2017. Multiparametric imaging for detection and characterization of hepatocellular carcinoma using gadoxetic acid-enhanced MRI and perfusion-CT: which parameters work best? Cancer Imaging 17, 18.

Perfahl, H., Hughes, B.D., Alarcón, T., Maini, P.K., Lloyd, M.C., Reuss, M., Byrne, H.M., 2017. 3D hybrid modelling of vascular network formation. Journal of Theoretical Biology 414, 254–268.

Schroeder, C.M., Hilke, F.J., Löffler, M.W., Bitzer, M., Lenz, F., Sturm, M., 2017. A comprehensive quality control workflow for paired tumor-normal NGS experiments. Bioinformatics 33, 1721–1722.


Dauch, D., Rudalska, R., Cossa, G., Nault, J.-C., Kang, T.-W., Wuestefeld, T., Hohmeyer, A., Imbeaud, S., Yevsa, T., Hoenicke, L., Pantsar, T., Bozko, P., Malek, N.P., Longerich, T., Laufer, S., Poso, A., Zucman-Rossi, J., Eilers, M., Zender, L., 2016. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat. Med. 22, 744–753.

Eggert, T., Wolter, K., Ji, J., Ma, C., Yevsa, T., Klotz, S., Medina-Echeverz, J., Longerich, T., Forgues, M., Reisinger, F., Heikenwalder, M., Wang, X.W., Zender, L., Greten, T.F., 2016. Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. Cancer Cell 30, 533–547.

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M.P., Matheson, N.J., Patten, D.A., Shetty, S., Parry, A.J., Menon, S., Salama, R., Antrobus, R., Tomimatsu, K., Howat, W., Lehner, P.J., Zender, L., Narita, M., 2016. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat. Cell Biol. 18, 979–992.

Syha, R., Grözinger, G., Grosse, U., Maurer, M., Zender, L., Horger, M., Nikolaou, K., Ketelsen, D., 2016. Parenchymal Blood Volume Assessed by C-Arm-Based Computed Tomography in Immediate Posttreatment Evaluation of Drug-Eluting Bead Transarterial Chemoembolization in Hepatocellular Carcinoma. Invest Radiol 51, 121–126.

Thaiss, W.M., Kaufmann, S., Kloth, C., Nikolaou, K., Bösmüller, H., Horger, M., 2016. VEGFR-2 expression in HCC, dysplastic and regenerative liver nodules, and correlation with pre-biopsy Dynamic Contrast Enhanced CT. Eur J Radiol 85, 2036–2041.


Kaufmann, S., Horger, T., Oelker, A., Beck, S., Schulze, M., Nikolaou, K., Ketelsen, D., Horger, M., 2015a. Volume perfusion computed tomography (VPCT)-based evaluation of response to TACE using two different sized drug eluting beads in patients with nonresectable hepatocellular carcinoma: Impact on tumor and liver parenchymal vascularisation. Eur J Radiol 84, 2548–2554.

Kaufmann, S., Horger, T., Oelker, A., Kloth, C., Nikolaou, K., Schulze, M., Horger, M., 2015b. Characterization of hepatocellular carcinoma (HCC) lesions using a novel CT-based volume perfusion (VPCT) technique. Eur J Radiol 84, 1029–1035.

Schneeweiß, S., Horger, M., Ketelsen, D., Ioanoviciu, S.D., 2015. [Complications after TACE in HCC]. Rofo 36, 79–82.


Dengel, B.-S., Perfahl, H., Galliani, S., Reuss, M., 2015. The VasCan Project: Simulation of Vascular Tumour Growth and Angiogenesis Using a Multiscale Model, in: High Performance Computing in Science and Engineering ‘14. Springer, Cham, pp. 683–691.