A systems medicine network

e:Med

Four new Demonstrators started

Four new interdisciplinary demonstrator research networks started in the middle/end of 2019 in the e:Med Module II Demonstrators for Individualised Medicine. They are initially funded by the BMBF with 8.3 million EUR. The concrete goal of the new demonstrators is the system-oriented (further) development of innovative methods and models in order to use them directly in the individualised prevention, diagnostics and therapy of human diseases such as chronic kidney disease (NephrESA), B-cell lymphoma (SeneSys), chronic inflammatory bowel diseases (GUIDE-IBD) and addictions such as alcohol dependence (Target-OXY).

e:Med

e:Med Kick-off Meeting 2020 in Bonn

Registration and abstract submission are open for the e:Med Kick-off meeting on Systems Medicine. The conference will take place March 8 -10, 2020 at the Biomedical Center in Bonn (Venusberg). Abstract submission deadline is November 4, 2019.
 

e:Med

Researcher`s Night

On Friday, September 27, 2019, the European Researchers‘ Night, an EU-funded initiative took place in Heidelberg / Mannheim. The e:Med Systems Medicine office was particularly well received by young visitors with their offer: their own name could be converted into the DNA code to make a very personal pearl bracelet.

Consortia

From basic research to drug precursors

Scientists from the e:Med alliance SMOOSE at the Technical University of Dortmund, in cooperation with physicians from Essen and Bochum, succeeded in producing a new AKT inhibitor, which is already showing initial efficacy against pancreatic cancer. The scientists succeeded in determining the first crystal structure of the complex of AKT1 with the new covalent alllosteric AKT inhibitor Borussertib, which provided important insights into the structural basis of the inhibition.

e:Med

Newsletter e:Medium 3

With this newsletter we would like to inform you about the results and activities of systems medical research in e:Med. Read about news on the development of anti-cancer agents, models for optimized drug delivery, the recurrence of glioblastomas, alcohol addiction in adolescence and the separation of relevant from irrelevant information in the brain.

Consortia and Demonstrators

Understanding Brain Tumors - Mathematical Model of Evolutionary Development

Glioblastomas frequently relapse despite subsequent radiation- and chemotherapy. Are there specific mutations that enable glioblastoma cells to evade therapy? To answer this question, scientists of the e:Med alliances SYS-GLIO and SYSMED-NB jointly investigated glioblastoma tissue samples of 50 affected persons.

Summer Schools

Interdisciplinary summer school ConISyM: Converging Imaging and Systems Medicine

The BMBF funded ConISyM Summer School 2019 under direction of Prof. Dr. med. Bernd Pichler focused on image processing in systems medicine. ConISyM aimed to strengthen methodological skills of young scientists and to open up new perspectives on their own projects. The young scientists were inspired to think beyond their own research field and learned new techniques that can be applied in combination to optimize their use in answering various scientific questions.

Junior Research Group

Hamid Noori receives animal welfare award

The Deutsche Forschungsgemeinschaft awarded the Ursula M. Händel Animal Welfare Prize of to PD Dr. Dr. Hamid Noori. The e: Med Junior Research Group Leader is a scientist at the Max Planck Institute for Biological Cybernetics in Tübingen, where he and his team have developed a database and computer models that can predict the effects of novel substances on the rat brain. As a result, new studies can be designed more purposefully, avoiding unnecessary animal experiments.

e:Med project groups - overlapping issues in focus

Scientists discuss new technologies and latest scientific contents and launch comprehensive initiatives in four e:Med project groups (PG) regarding substantially and methodologically overlapping systems medicine issues. The objective of the PG is to promote interactions between members and handle relevant issues across the research group.