PANC-STRAT

Publcations

2018

Bauer, A.S., Nazarov, P.V., Giese, N.A., Beghelli, S., Heller, A., Greenhalf, W., Costello, E., Muller, A., Bier, M., Strobel, O., Hackert, T., Vallar, L., Scarpa, A., Büchler, M.W., Neoptolemos, J.P., Kreis, S., Hoheisel, J.D., 2018. Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer. Int. J. Cancer 142, 1010–1021. doi.org/10.1002/ijc.31087

Felix, K., Hinz, U., Dobiasch, S., Hackert, T., Bergmann, F., Neumüller, M., Gronowitz, S., Bergqvist, M., Strobel, O., 2018. Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer. Pancreas 47, 72–79. doi.org/10.1097/MPA.0000000000000966

Heining, C., Horak, P., Uhrig, S., Codo, P.L., Klink, B., Hutter, B., Fröhlich, M., Bonekamp, D., Richter, D., Steiger, K., Penzel, R., Endris, V., Ehrenberg, K.R., Frank, S., Kleinheinz, K., Toprak, U.H., Schlesner, M., Mandal, R., Schulz, L., Lambertz, H., Fetscher, S., Bitzer, M., Malek, N.P., Horger, M.S., Giese, N.A., Strobel, O., Hackert, T., Springfeld, C., Feuerbach, L., Bergmann, F., Schröck, E., von Kalle, C., Weichert, W., Scholl, C., Ball, C.R., Stenzinger, A., Brors, B., Fröhling, S., Glimm, H., 2018. NRG1 Fusions in KRAS Wild-type Pancreatic Cancer. Cancer Discov. doi.org/10.1158/2159-8290.CD-18-0036

Jahreis, S., Trump, S., Bauer, M., Bauer, T., Thürmann, L., Feltens, R., Wang, Q., Gu, L., Grützmann, K., Röder, S., Averbeck, M., Weichenhan, D., Plass, C., Sack, U., Borte, M., Dubourg, V., Schüürmann, G., Simon, J.C., von Bergen, M., Hackermüller, J., Eils, R., Lehmann, I., Polte, T., 2018. Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications. J. Allergy Clin. Immunol. 141, 741–753. doi.org/10.1016/j.jaci.2017.03.017

Junge, K.M., Leppert, B., Jahreis, S., Wissenbach, D.K., Feltens, R., Grützmann, K., Thürmann, L., Bauer, T., Ishaque, N., Schick, M., Bewerunge-Hudler, M., Röder, S., Bauer, M., Schulz, A., Borte, M., Landgraf, K., Körner, A., Kiess, W., von Bergen, M., Stangl, G.I., Trump, S., Eils, R., Polte, T., Lehmann, I., 2018. MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development. Clin Epigenetics 10, 58. doi.org/10.1186/s13148-018-0478-z

Maier, L.J., Kallenberger, S.M., Jechow, K., Waschow, M., Eils, R., Conrad, C., 2018. Unraveling mitotic protein networks by 3D multiplexed epitope drug screening. Mol. Syst. Biol. 14, e8238.

Muckenhuber, A., Berger, A.K., Schlitter, A.M., Steiger, K., Konukiewitz, B., Trumpp, A., Eils, R., Werner, J., Friess, H., Esposito, I., Klöppel, G., Ceyhan, G.O., Jesinghaus, M., Denkert, C., Bahra, M., Stenzinger, A., Sprick, M.R., Jäger, D., Springfeld, C., Weichert, W., 2018. Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response. Clin. Cancer Res. 24, 351–359. doi.org/10.1158/1078-0432.CCR-17-2180

Reichert, M., Bakir, B., Moreira, L., Pitarresi, J.R., Feldmann, K., Simon, L., Suzuki, K., Maddipati, R., Rhim, A.D., Schlitter, A.M., Kriegsmann, M., Weichert, W., Wirth, M., Schuck, K., Schneider, G., Saur, D., Reynolds, A.B., Klein-Szanto, A.J., Pehlivanoglu, B., Memis, B., Adsay, N.V., Rustgi, A.K., 2018. Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev. Cell 45, 696-711.e8. doi.org/10.1016/j.devcel.2018.05.025

Schlereth, K., Weichenhan, D., Bauer, T., Heumann, T., Giannakouri, E., Lipka, D., Jaeger, S., Schlesner, M., Aloy, P., Eils, R., Plass, C., Augustin, H.G., 2018. The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife 7. doi.org/10.7554/eLife.34423

2017

Jabs, J., Zickgraf, F.M., Park, J., Wagner, S., Jiang, X., Jechow, K., Kleinheinz, K., Toprak, U.H., Schneider, M.A., Meister, M., Spaich, S., Sütterlin, M., Schlesner, M., Trumpp, A., Sprick, M., Eils, R., Conrad, C., 2017. Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. Mol. Syst. Biol. 13, 955.

Kaistha, B.P., Krattenmacher, A., Fredebohm, J., Schmidt, H., Behrens, D., Widder, M., Hackert, T., Strobel, O., Hoheisel, J.D., Gress, T.M., Buchholz, M., Kaistha, B.P., Krattenmacher, A., Fredebohm, J., Schmidt, H., Behrens, D., Widder, M., Hackert, T., Strobel, O., Hoheisel, J.D., Gress, T.M., Buchholz, M., 2017. The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators. Oncotarget 8, 66215–66225. doi.org/10.18632/oncotarget.19882

Kuhlmann, L., Nadler, W.M., Kerner, A., Hanke, S.A., Noll, E.M., Eisen, C., Espinet, E., Vogel, V., Trumpp, A., Sprick, M.R., Roesli, C.P., 2017. Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma. Pancreas 46, 311–322. doi.org/10.1097/MPA.0000000000000743

Reisinger, E., Genthner, L., Kerssemakers, J., Kensche, P., Borufka, S., Jugold, A., Kling, A., Prinz, M., Scholz, I., Zipprich, G., Eils, R., Lawerenz, C., Eils, J., 2017. OTP: An automatized system for managing and processing NGS data. J. Biotechnol. doi.org/10.1016/j.jbiotec.2017.08.006

Senís, E., Mockenhaupt, S., Rupp, D., Bauer, T., Paramasivam, N., Knapp, B., Gronych, J., Grosse, S., Windisch, M.P., Schmidt, F., Theis, F.J., Eils, R., Lichter, P., Schlesner, M., Bartenschlager, R., Grimm, D., 2017. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res. 45, e3. doi.org/10.1093/nar/gkw805

2016

Bauer, T., Trump, S., Ishaque, N., Thürmann, L., Gu, L., Bauer, M., Bieg, M., Gu, Z., Weichenhan, D., Mallm, J.-P., Röder, S., Herberth, G., Takada, E., Mücke, O., Winter, M., Junge, K.M., Grützmann, K., Rolle-Kampczyk, U., Wang, Q., Lawerenz, C., Borte, M., Polte, T., Schlesner, M., Schanne, M., Wiemann, S., Geörg, C., Stunnenberg, H.G., Plass, C., Rippe, K., Mizuguchi, J., Herrmann, C., Eils, R., Lehmann, I., 2016. Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol. Syst. Biol. 12, 861. doi.org/10.15252/msb.20156520

Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel, V., Klaus, B., Nadler, W., Rösli, C., Lutz, C., Kulke, M., Engelhardt, J., Zickgraf, F.M., Espinosa, O., Schlesner, M., Jiang, X., Kopp-Schneider, A., Neuhaus, P., Bahra, M., Sinn, B.V., Eils, R., Giese, N.A., Hackert, T., Strobel, O., Werner, J., Büchler, M.W., Weichert, W., Trumpp, A., Sprick, M.R., 2016. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nat. Med. 22, 278–287. doi.org/10.1038/nm.4038

Poschke, I., Faryna, M., Bergmann, F., Flossdorf, M., Lauenstein, C., Hermes, J., Hinz, U., Hank, T., Ehrenberg, R., Volkmar, M., Loewer, M., Glimm, H., Hackert, T., Sprick, M.R., Höfer, T., Trumpp, A., Halama, N., Hassel, J.C., Strobel, O., Büchler, M., Sahin, U., Offringa, R., 2016. Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma. OncoImmunology 5, e1240859. doi.org/10.1080/2162402X.2016.1240859