SYSIMIT

Publications

2018

Danisch, S., Slabik, C., Cornelius, A., Albanese, M., Tagawa, T., Chen, Y. A., Kronke, N., Eiz-Vesper, B., Lienenklaus, S., Bleich, A., Theobald, S. J., Schneider, A., Ganser, A., von Kaisenberg, C., Zeidler, R., Hammerschmidt, W., Feuerhake, F.Stripecke, R., 2018. Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1-Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice. Am J Pathol. doi.org/10.1016/j.ajpath.2018.11.014

Lopez Alfonso, J. C., Parsai, S., Joshi, N., Godley, A., Shah, C., Koyfman, S. A., Caudell, J. J., Fuller, C. D., Enderling, H.Scott, J. G., 2018. Temporally feathered intensity-modulated radiation therapy: A planning technique to reduce normal tissue toxicity. Med Phys, 45(7), 3466-3474. doi.org/10.1002/mp.12988

Meyer-Hermann, M., 2018. Estimation of the cancer risk induced by therapies targeting stem cell replication and treatment recommendations. Sci Rep, 8(1), 11776. doi.org/10.1038/s41598-018-29967-6

Meyer-Hermann, M., Binder, S. C., Mesin, L.Victora, G. D., 2018. Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers. Front. Immunol., 9. doi.org/10.3389/fimmu.2018.02020

Montaseri, G., Boianelli, A., Hernandez-Vargas, E. A.Meyer-Hermann, M., 2018. PK/PD-based adaptive tailoring of oseltamivir doses to treat within-host influenza viral infections. Prog. Biophys. Mol. Biol., 139, 31-42. doi.org/10.1016/j.pbiomolbio.2018.07.007

Theobald, S. J., Khailaie, S., Meyer-Hermann, M., Volk, V., Olbrich, H., Danisch, S., Gerasch, L., Schneider, A., Sinzger, C., Schaudien, D., Lienenklaus, S., Riese, P., Guzman, C. A., Figueiredo, C., von Kaisenberg, C., Spineli, L. M., Glaesener, S., Meyer-Bahlburg, A., Ganser, A., Schmitt, M., Mach, M., Messerle, M.Stripecke, R., 2018. Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells. Front. Immunol., 9. doi.org/10.3389/fimmu.2018.02734

2017

Alfonso, J.C.L., Talkenberger, K., Seifert, M., Klink, B., Hawkins-Daarud, A., Swanson, K.R., Hatzikirou, H., Deutsch, A., 2017. The biology and mathematical modelling of glioma invasion: a review. J R Soc Interface 14. doi.org/10.1098/rsif.2017.0490

Hatzikirou, H., López Alfonso, J.C., Leschner, S., Weiss, S., Meyer-Hermann, M., 2017. Therapeutic Potential of Bacteria against Solid Tumors. Cancer Res. 77, 1553–1563. doi.org/10.1158/0008-5472.CAN-16-1621

Khailaie, S., Rowshanravan, B., Robert, P.A., Walker, L.S.K., Sansom, D.M., Meyer-Hermann, M., 2017. Quantitative characterization of CTLA4 trafficking and turnover using a combined in vitro and in silico approach. bioRxiv 106898. doi.org/10.1101/106898

Nava-Sedeño, J.M., Hatzikirou, H., Klages, R., Deutsch, A., 2017a. Cellular automaton models for time-correlated random walks: derivation and analysis. Sci Rep 7, 16952. doi.org/10.1038/s41598-017-17317-x

Nava-Sedeño, J.M., Hatzikirou, H., Peruani, F., Deutsch, A., 2017b. Extracting cellular automaton rules from physical Langevin equation models for single and collective cell migration. J Math Biol. doi.org/10.1007/s00285-017-1106-9

Schaadt, N.S., Alfonso, J.C.L., Schönmeyer, R., Grote, A., Forestier, G., Wemmert, C., Krönke, N., Stoeckelhuber, M., Kreipe, H.H., Hatzikirou, H., Feuerhake, F., 2017. Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis. Breast Cancer Res Treat 1–11. doi.org/10.1007/s10549-017-4239-z

Volk, V., Reppas, A.I., Robert, P.A., Spineli, L.M., Sundarasetty, B.S., Theobald, S.J., Schneider, A., Gerasch, L., Deves Roth, C., Klöss, S., Koehl, U., von Kaisenberg, C., Figueiredo, C., Hatzikirou, H., Meyer-Hermann, M., Stripecke, R., 2017. Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization. Front Immunol 8, 1709. doi.org/10.3389/fimmu.2017.01709

2016

Alfonso, J.C.L., Köhn-Luque, A., Stylianopoulos, T., Feuerhake, F., Deutsch, A., Hatzikirou, H., 2016a. Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights. Sci Rep 6, 37283. doi.org/10.1038/srep37283

Alfonso, J.C.L., Schaadt, N.S., Schönmeyer, R., Brieu, N., Forestier, G., Wemmert, C., Feuerhake, F., Hatzikirou, H., 2016b. In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium. Sci Rep 6, 33322. doi.org/10.1038/srep33322

Binder, S.C., Eckweiler, D., Schulz, S., Bielecka, A., Nicolai, T., Franke, R., Häussler, S., Meyer-Hermann, M., 2016. Functional modules of sigma factor regulons guarantee adaptability and evolvability. Sci Rep 6, 22212. doi.org/10.1038/srep22212

Boianelli, A., Sharma-Chawla, N., Bruder, D., Hernandez-Vargas, E.A., 2016. Oseltamivir PK/PD Modeling and Simulation to Evaluate Treatment Strategies against Influenza-Pneumococcus Coinfection. Front Cell Infect Microbiol 6, 60. doi.org/10.3389/fcimb.2016.00060

Ghanbari, A., Dehghany, J., Schwebs, T., Müsken, M., Häussler, S., Meyer-Hermann, M., 2016. Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms. Sci Rep 6, 32097. doi.org/10.1038/srep32097

2015

Apou, G., Feuerhake, F., Forestier, G., Naegel, B., Wemmert, C., 2015. Synthesizing whole slide images, in: 2015 9th International Symposium on Image and Signal Processing and Analysis (ISPA). Presented at the 2015 9th International Symposium on Image and Signal Processing and Analysis (ISPA), pp. 154–159. doi.org/10.1109/ISPA.2015.7306050

Binder, S.C., Hernandez-Vargas, E.A., Meyer-Hermann, M., 2015. Reducing complexity: An iterative strategy for parameter determination in biological networks. Computer Physics Communications 190, 15–22. doi.org/10.1016/j.cpc.2015.01.001

Boianelli, A., Nguyen, V.K., Ebensen, T., Schulze, K., Wilk, E., Sharma, N., Stegemann-Koniszewski, S., Bruder, D., Toapanta, F.R., Guzmán, C.A., Meyer-Hermann, M., Hernandez-Vargas, E.A., 2015. Modeling Influenza Virus Infection: A Roadmap for Influenza Research. Viruses 7, 5274–5304. doi.org/10.3390/v7102875

Hatzikirou, H., Alfonso, J.C.L., Mühle, S., Stern, C., Weiss, S., Meyer-Hermann, M., 2015. Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions. J R Soc Interface 12. doi.org/10.1098/rsif.2015.0439

Kempf, H., Bleicher, M., Meyer-Hermann, M., 2015. Spatio-Temporal Dynamics of Hypoxia during Radiotherapy. PLoS ONE 10, e0133357. doi.org/10.1371/journal.pone.0133357

Nguyen, V.K., Binder, S.C., Boianelli, A., Meyer-Hermann, M., Hernandez-Vargas, E.A., 2015. Ebola virus infection modeling and identifiability problems. Front Microbiol 6, 257. doi.org/10.3389/fmicb.2015.00257

Sukhorukov, V.M., Meyer-Hermann, M., 2015. Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton. Sci Rep 5, 13924. doi.org/10.1038/srep13924

2014

 

 

Haering, M., Hördt, A., Meyer-Hermann, M., Hernandez-Vargas, E.A., 2014. Computational study to determine when to initiate and alternate therapy in HIV infection. Biomed Res Int 2014, 472869. doi.org/10.1155/2014/472869

Meyer-Hermann, M., 2014. Overcoming the dichotomy of quantity and quality in antibody responses. J. Immunol. 193, 5414–5419. doi.org/10.4049/jimmunol.1401828

Zhao, G., Dharmadhikari, G., Maedler, K., Meyer-Hermann, M., 2014. Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies. PLoS Comput. Biol. 10, e1003798. doi.org/10.1371/journal.pcbi.1003798

2013

 

 

Kempf, H., Hatzikirou, H., Bleicher, M., Meyer-Hermann, M., 2013. In silico analysis of cell cycle synchronisation effects in radiotherapy of tumour spheroids. PLoS Comput. Biol. 9, e1003295. doi.org/10.1371/journal.pcbi.1003295