SP 1

Mathematisches Modell zur Entstehung ektopischer Lymphfollikel im Kontext von Nierentransplantationen

After renal transplantation there is a risk of induction of a host immune response against the graft, which may lead to rejection and loss of function of the transplanted organ. Currently available prognostic factors are not always sufficient to predict a developing rejection early enough to adapt the immunosuppressive therapy in time. In order to utilize the full predictive potential of routinely obtained tissue samples (so-called "protocol biopsies"), we investigate early indications of newly formed lymphatic structures. Potentially, these structures develop long time before detection of antibodies directed against the graft (the donor-specific antibodies). With the help of dynamic mathematical models we aim at determining early signs of the formation of such displaced (ectopic) lymphoid structures.

Three-dimensional simulation of the formation of lymphoid B cell follicles using the Delaunay-Object-Dynamics methodology.

The generated knowledge on early signs of ectopic lymph structures and on their relevance for graft rejection are integrated in computer-assisted analysis workflows to evaluate microscopic images from clinically collected biopsies. We expect insights into the underlying immunological processes enabling  innovative and individually tailored therapy approaches for patients in need.