Publications

 

Enter a keyword and click on the buttons below to see the results.

July 2018

Konsortium CAPSyS

Hopp, L., Loeffler-Wirth, H., Nersisyan, L., Arakelyan, A., Binder, H., 2018. Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome. Front Immunol 9, 1620. doi.org/10.3389/fimmu.2018.01620

 

Konsortium CLIOMMICS

Merz, M., Hielscher, T., Hoffmann, K., Seckinger, A., Hose, D., Raab, M.S., Hillengass, J., Jauch, A., Goldschmidt, H., 2018. Cytogenetic abnormalities in monoclonal gammopathy of undetermined significance. Leukemia. doi.org/10.1038/s41375-018-0202-1

Seckinger, A., Hillengass, J., Emde, M., Beck, S., Kimmich, C., Dittrich, T., Hundemer, M., Jauch, A., Hegenbart, U., Raab, M.-S., Ho, A.D., Schönland, S., Hose, D., 2018. CD38 as Immunotherapeutic Target in Light Chain Amyloidosis and Multiple Myeloma-Association With Molecular Entities, Risk, Survival, and Mechanisms of Upfront Resistance. Front Immunol 9, 1676. doi.org/10.3389/fimmu.2018.01676

 

Juniorverbund DeCaRe

He, Y., Thriene, K., Boerries, M., Hausser, I., Franzke, C.-W., Busch, H., Dengjel, J., Has, C., 2018. Constitutional absence of epithelial integrin α3 impacts the composition of the cellular microenvironment of ILNEB keratinocytes. Matrix Biology. doi.org/10.1016/j.matbio.2018.07.001

 

Konsortium e:Athero-Sysmed

Malik, R., Dichgans, M., 2018. Challenges and opportunities in stroke genetics. Cardiovasc. Res. 114, 1226–1240. doi.org/10.1093/cvr/cvy068

Konsortium e:Athero-Sysmed & Vernetzungsfond AbCD-Net

Erdmann, J., Kessler, T., Munoz Venegas, L., Schunkert, H., 2018. A decade of genome-wide association studies for coronary artery disease: the challenges ahead. Cardiovasc. Res. 114, 1241–1257. doi.org/10.1093/cvr/cvy084

Schunkert, H., Samani, N.J., 2018. Into the great wide open: 10 years of genome-wide association studies. Cardiovasc. Res. 114, 1189–1191. doi.org/10.1093/cvr/cvy100

Schunkert, H., von Scheidt, M., Kessler, T., Stiller, B., Zeng, L., Vilne, B., 2018. Genetics of coronary artery disease in the light of genome-wide association studies. Clin Res Cardiol 107, 2–9. doi.org/10.1007/s00392-018-1324-1

 

Konsortium e:Kid

Blazquez-Navarro, A., Dang-Heine, C., Wittenbrink, N., Bauer, C., Wolk, K., Sabat, R., Westhoff, T.H., Sawitzki, B., Reinke, P., Thomusch, O., Hugo, C., Or-Guil, M., Babel, N., 2018. BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study. EBioMedicine. doi.org/10.1016/j.ebiom.2018.07.017

 

Demonstrator HER2Low

Breunig, C., Erdem, N., Bott, A., Greiwe, J.F., Reinz, E., Bernhardt, S., Giacomelli, C., Wachter, A., Kanthelhardt, E.J., Beißbarth, T., Vetter, M., Wiemann, S., 2018. TGFβ1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer. Mol Oncol 12, 1447–1463. doi.org/10.1002/1878-0261.12355

 

Konsortium IntegraMent

Trepte, P., Kruse, S., Kostova, S., Hoffmann, S., Buntru, A., Tempelmeier, A., Secker, C., Diez, L., Schulz, A., Klockmeier, K., Zenkner, M., Golusik, S., Rau, K., Schnoegl, S., Garner, C.C., Wanker, E.E., 2018. LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Mol. Syst. Biol. 14, e8071.

 

Juniorverbund MILES

Gao, F., Thiebes, S., Sunyaev, A., 2018. Rethinking the Meaning of Cloud Computing for Health Care: A Taxonomic Perspective and Future Research Directions. J. Med. Internet Res. 20, e10041. doi.org/10.2196/10041

 

Juniorverbund mitOmics

Yépez, V.A., Kremer, L.S., Iuso, A., Gusic, M., Kopajtich, R., Koňaříková, E., Nadel, A., Wachutka, L., Prokisch, H., Gagneur, J., 2018. OCR-Stats: Robust estimation and statistical testing of mitochondrial respiration activities using Seahorse XF Analyzer. PLoS ONE 13, e0199938. https://doi.org/10.1371/journal.pone.0199938

Gregor, A., Sadleir, L.G., Asadollahi, R., Azzarello-Burri, S., Battaglia, A., Ousager, L.B., Boonsawat, P., Bruel, A.-L., Buchert, R., Calpena, E., Cogné, B., Dallapiccola, B., Distelmaier, F., Elmslie, F., Faivre, L., Haack, T.B., Harrison, V., Henderson, A., Hunt, D., Isidor, B., Joset, P., Kumada, S., Lachmeijer, A.M.A., Lees, M., Lynch, S.A., Martinez, F., Matsumoto, N., McDougall, C., Mefford, H.C., Miyake, N., Myers, C.T., Moutton, S., Nesbitt, A., Novelli, A., Orellana, C., Rauch, A., Rosello, M., Saida, K., Santani, A.B., Sarkar, A., Scheffer, I.E., Shinawi, M., Steindl, K., Symonds, J.D., Zackai, E.H., University of Washington Center for Mendelian Genomics, DDD Study, Reis, A., Sticht, H., Zweier, C., 2018. De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder. Am. J. Hum. Genet. 103, 305–316. doi.org/10.1016/j.ajhg.2018.07.003

Demonstrator MitoPD

Fussi, N., Höllerhage, M., Chakroun, T., Nykänen, N.-P., Rösler, T.W., Koeglsperger, T., Wurst, W., Behrends, C., Höglinger, G.U., 2018. Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy. Cell Death Dis 9, 757. doi.org/10.1038/s41419-018-0816-2

 

Juniorverbund PsychoSys

Messer, M., Albert, S., Schneider, G., 2018. The multiple filter test for change point detection in time series. Metrika 81, 589–607. doi.org/10.1007/s00184-018-0672-1

Jacob, S.N., Nienborg, H., 2018. Monoaminergic Neuromodulation of Sensory Processing. Front Neural Circuits 12, 51. doi.org/10.3389/fncir.2018.00051

 

Konsortium SMOOSE

Knittel, G., Rehkämper, T., Nieper, P., Schmitt, A., Flümann, R., Reinhardt, H.C., 2018. DNA damage pathways and B-cell lymphomagenesis. Curr. Opin. Hematol. 25, 315–322. doi.org/10.1097/MOH.0000000000000433

Wiedemann, B., Weisner, J., Rauh, D., 2018. Chemical modulation of transcription factors. Medchemcomm 9, 1249–1272. https://doi.org/10.1039/c8md00273h

Juniorverbund SYMBOL-HF

Helferich, A.M., Brockmann, S.J., Reinders, J., Deshpande, D., Holzmann, K., Brenner, D., Andersen, P.M., Petri, S., Thal, D.R., Michaelis, J., Otto, M., Just, S., Ludolph, A.C., Danzer, K.M., Freischmidt, A., Weishaupt, J.H., 2018. Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS. Cell. Mol. Life Sci. doi.org/10.1007/s00018-018-2873-1

Kustermann, M., Manta, L., Paone, C., Kustermann, J., Lausser, L., Wiesner, C., Eichinger, L., Clemen, C.S., Schröder, R., Kestler, H.A., Sandri, M., Rottbauer, W., Just, S., 2018. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy. doi.org/10.1080/15548627.2018.1491491

Segert, J., Schneider, I., Berger, I.M., Rottbauer, W., Just, S., 2018. Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish. Progress in Biophysics and Molecular Biology. doi.org/10.1016/j.pbiomolbio.2018.07.010

August 2018

Konsortium CancerTelSys

Kluth, M., Scherzai, S., Büschek, F., Fraune, C., Möller, K., Höflmayer, D., Minner, S., Göbel, C., Möller-Koop, C., Hinsch, A., Neubauer, E., Tsourlakis, M.C., Sauter, G., Heinzer, H., Graefen, M., Wilczak, W., Luebke, A.M., Burandt, E., Steurer, S., Schlomm, T., Simon, R., 2018. 13q deletion is linked to an adverse phenotype and poor prognosis in prostate cancer. Genes Chromosomes Cancer 57, 504–512. doi.org/10.1002/gcc.22645

Konsortium CAPSyS

Marin-Sanguino, A., Vera, J., Alves, R., 2018. Editorial: Foundations of Theoretical Approaches in Systems Biology. Front. Genet. 9, 290. doi.org/10.3389/fgene.2018.00290

Konsortium CLIOMMICS

Chattopadhyay, S., Yu, H., Sud, A., Sundquist, J., Försti, A., Hemminki, A., Hemminki, K., 2018. Multiple myeloma: family history and mortality in second primary cancers. Blood Cancer J 8, 75. doi.org/10.1038/s41408-018-0108-1

Mahmoudpour, S.H., Bandapalli, O.R., da Silva Filho, M.I., Campo, C., Hemminki, K., Goldschmidt, H., Merz, M., Försti, A., 2018. Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients. BMC Cancer 18, 820. doi.org/10.1186/s12885-018-4728-4

Konsortium e:Kid

Baron, U., Werner, J., Schildknecht, K., Schulze, J.J., Mulu, A., Liebert, U.-G., Sack, U., Speckmann, C., Gossen, M., Wong, R.J., Stevenson, D.K., Babel, N., Schürmann, D., Baldinger, T., Bacchetta, R., Grützkau, A., Borte, S., Olek, S., 2018. Epigenetic immune cell counting in human blood samples for immunodiagnostics. Sci Transl Med 10. doi.org/10.1126/scitranslmed.aan3508

Demonstrator HaematoOpt

Glauche, I., Kuhn, M., Baldow, C., Schulze, P., Rothe, T., Liebscher, H., Roy, A., Wang, X., Roeder, I., 2018. Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison. Sci Rep 8, 12330. doi.org/10.1038/s41598-018-29923-4

Konsortium IntegraMent

Foo, J.C., Streit, F., Treutlein, J., Ripke, S., Witt, S.H., Strohmaier, J., Degenhardt, F., Forstner, A.J., Hoffmann, P., Soyka, M., Dahmen, N., Scherbaum, N., Wodarz, N., Heilmann-Heimbach, S., Herms, S., Cichon, S., Preuss, U., Gaebel, W., Ridinger, M., Hoffmann, S., Schulze, T.G., Maier, W., Zill, P., Müller-Myhsok, B., Ising, M., Lucae, S., Nöthen, M.M., Mann, K., Kiefer, F., Rietschel, M., Frank, J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 2018. Shared genetic etiology between alcohol dependence and major depressive disorder. Psychiatr. Genet. 28, 66–70. doi.org/10.1097/YPG.0000000000000201

Chen, J., Cao, H., Meyer-Lindenberg, A., Schwarz, E., 2018. Male increase in brain gene expression variability is linked to genetic risk for schizophrenia. Transl Psychiatry 8, 140. doi.org/10.1038/s41398-018-0200-0

Papanastasiou, E., Mouchlianitis, E., Joyce, D.W., McGuire, P., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Spechler, P., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Millenet, S., Fröhner, J.H., Smolka, M.N., Walter, H., Whelan, R., Schumann, G., Shergill, S., IMAGEN Consortium, 2018. Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing. JAMA Psychiatry. doi.org/10.1001/jamapsychiatry.2018.1973

Deussing, J.M., Arzt, E., 2018. P2X7 Receptor: A Potential Therapeutic Target for Depression? Trends Mol Med 24, 736–747. doi.org/10.1016/j.molmed.2018.07.005

Deussing, J.M., Chen, A., 2018. The Corticotropin-Releasing Factor Family: Physiology of the Stress Response. Physiol. Rev. 98, 2225–2286. doi.org/10.1152/physrev.00042.2017

Corominas, J., Klein, M., Zayats, T., Rivero, O., Ziegler, G.C., Pauper, M., Neveling, K., Poelmans, G., Jansch, C., Svirin, E., Geissler, J., Weber, H., Reif, A., Arias Vasquez, A., Galesloot, T.E., Kiemeney, L.A.L.M., Buitelaar, J.K., Ramos-Quiroga, J.-A., Cormand, B., Ribasés, M., Hveem, K., Gabrielsen, M.E., Hoffmann, P., Cichon, S., Haavik, J., Johansson, S., Jacob, C.P., Romanos, M., Franke, B., Lesch, K.-P., 2018. Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing. Mol. Psychiatry. doi.org/10.1038/s41380-018-0210-6

Comes, A.L., Papiol, S., Mueller, T., Geyer, P.E., Mann, M., Schulze, T.G., 2018. Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future. Transl Psychiatry 8, 160. doi.org/10.1038/s41398-018-0219-2

Demonstrator MMML-Demonstrator

Zacharias, H.U., Altenbuchinger, M., Gronwald, W., 2018. Statistical Analysis of NMR Metabolic Fingerprints: Established Methods and Recent Advances. Metabolites 8. doi.org/10.3390/metabo8030047

Konsortium PANC-STRAT

Maier, L.J., Kallenberger, S.M., Jechow, K., Waschow, M., Eils, R., Conrad, C., 2018. Unraveling mitotic protein networks by 3D multiplexed epitope drug screening. Mol. Syst. Biol. 14, e8238.

Juniorverbund PsychoSys

Jacob, S.N., Hähnke, D., Nieder, A., 2018. Structuring of Abstract Working Memory Content by Fronto-parietal Synchrony in Primate Cortex. Neuron 99, 588-597.e5. doi.org/10.1016/j.neuron.2018.07.025

Konsortium SMOOSE

Wolle, P., Weisner, J., Keul, M., Landel, I., Lategahn, J., Rauh, D., 2018. RASPELD to Perform High-End Screening in an Academic Environment Toward the Development of Cancer Therapeutics. ChemMedChem. doi.org/10.1002/cmdc.201800477

Konsortium SysINFLAME

Fliegauf, M., Grimbacher, B., 2018. NFkB mutations in humans: The devil is in the details. J. Allergy Clin. Immunol. doi.org/10.1016/j.jaci.2018.06.050

Schulte-Wrede, U., Sörensen, T., Grün, J.R., Häupl, T., Hirseland, H., Steinbrich-Zöllner, M., Wu, P., Radbruch, A., Poddubnyy, D., Sieper, J., Syrbe, U., Grützkau, A., 2018. An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus. Arthritis Res. Ther. 20, 191. doi.org/10.1186/s13075-018-1692-y

Konsortium SysMedAlcoholism

Bayard, F., Nymberg Thunell, C., Abé, C., Almeida, R., Banaschewski, T., Barker, G., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Martinot, M.-L.P., Nees, F., Orfanos, D.P., Paus, T., Poustka, L., Conrod, P., Stringaris, A., Struve, M., Penttilä, J., Kappel, V., Grimmer, Y., Fadai, T., van Noort, B., Smolka, M.N., Vetter, N.C., Walter, H., Whelan, R., Schumann, G., Petrovic, P., IMAGEN Consortium, 2018. Distinct brain structure and behavior related to ADHD and conduct disorder traits. Mol. Psychiatry. doi.org/10.1038/s41380-018-0202-6

Macare, C., Ducci, F., Zhang, Y., Ruggeri, B., Jia, T., Kaakinen, M., Kalsi, G., Charoen, P., Casoni, F., Peters, J., Bromberg, U., Hill, M., Buxton, J., Blakemore, A., Veijola, J., Büchel, C., Banaschewski, T., Bokde, A.L.W., Conrod, P., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P.A., Heinz, A., Ittermann, B., Lathrop, M., Martinot, J.-L., Paus, T., Desrivières, S., Munafò, M., Järvelin, M.-R., Schumann, G., 2018. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. European Neuropsychopharmacology. doi.org/10.1016/j.euroneuro.2018.07.101

Patel, Y., Shin, J., Gowland, P.A., Pausova, Z., Paus, T., IMAGEN consortium, 2018. Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor? Cereb. Cortex. doi.org/10.1093/cercor/bhy204

June 2018

Konsortium CancerTelSys

Luke, B., 2018. Telomere regulation. Differentiation 102, 27–29. doi.org/10.1016/j.diff.2018.06.002

 

Konsortium CAPSyS

Vera González, J., Santos-Rosales, G., 2018. Can gamification contribute to computer modeling-driven biomedical research? Front. Physiol. 9. doi.org/10.3389/fphys.2018.00908

 

Konsortium CLIOMMICS

Chattopadhyay, S., Thomsen, H., da Silva Filho, M.I., Weinhold, N., Hoffmann, P., Nöthen, M.M., Marina, A., Jöckel, K.-H., Schmidt, B., Pechlivanis, S., Langer, C., Goldschmidt, H., Hemminki, K., Försti, A., 2018. Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study. Molecular Medicine 24, 30. doi.org/10.1186/s10020-018-0031-8

 

Juniorverbund DeCaRe

Dvornikov, D., Schneider, M.A., Ohse, S., Szczygieł, M., Titkova, I., Rosenblatt, M., Muley, T., Warth, A., Herth, F.J., Dienemann, H., Thomas, M., Timmer, J., Schilling, M., Busch, H., Boerries, M., Meister, M., Klingmüller, U., 2018. Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response. Sci Rep 8, 9517. doi.org/10.1038/s41598-018-27912-1

Viau, A., Bienaimé, F., Lukas, K., Todkar, A.P., Knoll, M., Yakulov, T.A., Hofherr, A., Kretz, O., Helmstädter, M., Reichardt, W., Braeg, S., Aschman, T., Merkle, A., Pfeifer, D., Dumit, V.I., Gubler, M.-C., Nitschke, R., Huber, T.B., Terzi, F., Dengjel, J., Grahammer, F., Köttgen, M., Busch, H., Boerries, M., Walz, G., Triantafyllopoulou, A., Kuehn, E.W., 2018. Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney. EMBO J. 37. doi.org/10.15252/embj.201798615

Koszinowski, S., La Padula, V., Edlich, F., Krieglstein, K., Busch, H., Boerries, M., 2018. Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development. Front Physiol 9, 797. doi.org/10.3389/fphys.2018.00797

 

Demonstrator HaematoOpt

Fassoni, A.C., Baldow, C., Roeder, I., Glauche, I., 2018. Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: A simulation study based on phase 3 trial data. Haematologica. doi.org/10.3324/haematol.2018.194522

Suttorp, M., Schulze, P., Glauche, I., Göhring, G., von Neuhoff, N., Metzler, M., Sedlacek, P., de Bont, E.S.J.M., Balduzzi, A., Lausen, B., Aleinikova, O., Sufliarska, S., Henze, G., Strauss, G., Eggert, A., Kremens, B., Groll, A.H., Berthold, F., Klein, C., Groß-Wieltsch, U., Sykora, K.W., Borkhardt, A., Kulozik, A.E., Schrappe, M., Nowasz, C., Krumbholz, M., Tauer, J.T., Claviez, A., Harbott, J., Kreipe, H.H., Schlegelberger, B., Thiede, C., 2018. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Leukemia. doi.org/10.1038/s41375-018-0179-9

 

Konsortium IntegraMent

Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., …., Nöthen, M.M., ..., Muller-Myhsok, B., Schreiber, S., ... Gasser, T., Gibbs, R., Heutink, P., …., Banaschewski, T., …, Schulze, T.G…, Cichon, S., Mühleisen, T.W., Degenhardt, F., …., Forstner, A.J., Streit, F., Baune, B.T., …., Dichgans, M., et al.,2018. Analysis of shared heritability in common disorders of the brain. Science 360. doi.org/10.1126/science.aap8757

Kalman, J.L., Papiol, S., Forstner, A.J., Heilbronner, U., Degenhardt, F., Strohmaier, J., Adli, M., Adorjan, K., Akula, N., Alda, M., Anderson-Schmidt, H., Andlauer, T.F., Anghelescu, I.-G., Ardau, R., Arias, B., Arolt, V., Aubry, J.-M., Backlund, L., Bartholdi, K., Bauer, M., Baune, B.T., Becker, T., Bellivier, F., Benabarre, A., Bengesser, S., Bhattacharjee, A.K., Biernacka, J.M., Birner, A., Brichant-Petitjean, C., Budde, M., Cervantes, P., Chillotti, C., Cichon, S., Clark, S.R., Colom, F., Comes, A.L., Cruceanu, C., Czerski, P.M., Dannlowski, U., Dayer, A., Del Zompo, M., DePaulo, J.R., Dietrich, D.E., Étain, B., Ethofer, T., Falkai, P., Fallgatter, A., Figge, C., Flatau, L., Folkerts, H., Frisen, L., Frye, M.A., Fullerton, J.M., Gade, K., Gard, S., Garnham, J.S., Goes, F.S., Grigoroiu-Serbanescu, M., Gryaznova, A., Hake, M., Hauser, J., Herms, S., Hoffmann, P., Hou, L., Jäger, M., Jamain, S., Jiménez, E., Juckel, G., Kahn, J.-P., Kassem, L., Kelsoe, J., Kittel-Schneider, S., Kliwicki, S., Klohn-Sagatholislam, F., Koller, M., König, B., Konrad, C., Lackner, N., Laje, G., Landén, M., Lang, F.U., Lavebratt, C., Leboyer, M., Leckband, S.G., Maj, M., Manchia, M., Martinsson, L., McCarthy, M.J., McElroy, S.L., McMahon, F.J., Mitchell, P.B., Mitjans, M., Mondimore, F.M., Monteleone, P., Nieratschker, V., Nievergelt, C.M., Novák, T., Ösby, U., Pfennig, A., Potash, J.B., Reich-Erkelenz, D., Reif, A., Reimer, J., Reininghaus, E., Reitt, M., Ripke, S., Rouleau, G.A., Rybakowski, J.K., Schalling, M., Scherk, H., Schmauß, M., Schofield, P.R., Schubert, K.O., Schulte, E.C., Schulz, S., Senner, F., Severino, G., Shekhtman, T., Shilling, P.D., Simhandl, C., Slaney, C.M., Spitzer, C., Squassina, A., Stamm, T., Stegmaier, S., Stierl, S., Stopkova, P., Thiel, A., Tighe, S.K., Tortorella, A., Turecki, G., Vieta, E., Veeh, J., von Hagen, M., Wigand, M.E., Wiltfang, J., Witt, S., Wright, A., Zandi, P.P., Zimmermann, J., Nöthen, M., Rietschel, M., Schulze, T.G., 2018. Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study. Bipolar Disord. doi.org/10.1111/bdi.12659

 

Juniorverbund mitOmics

Alhaddad, B., Schossig, A., Haack, T.B., Kovács-Nagy, R., Braunisch, M.C., Makowski, C., Senderek, J., Vill, K., Müller-Felber, W., Strom, T.M., Krabichler, B., Freisinger, P., Deshpande, C., Polster, T., Wolf, N.I., Desguerre, I., Wörmann, F., Rötig, A., Ahting, U., Kopajtich, R., Prokisch, H., Meitinger, T., Feichtinger, R.G., Mayr, J.A., Jungbluth, H., Hubmann, M., Zschocke, J., Distelmaier, F., Koch, J., 2018. PRUNE1 Deficiency: Expanding the Clinical and Genetic Spectrum. Neuropediatrics. doi.org/10.1055/s-0038-1661396

Iuso, A., Alhaddad, B., Weigel, C., Kotzaeridou, U., Mastantuono, E., Schwarzmayr, T., Graf, E., Terrile, C., Prokisch, H., Strom, T.M., Hoffmann, G.F., Meitinger, T., Haack, T.B., 2018. A Homozygous Splice Site Mutation in SLC25A42, Encoding the Mitochondrial Transporter of Coenzyme A, Causes Metabolic Crises and Epileptic Encephalopathy. JIMD Rep. doi.org/10.1007/8904_2018_115

 

Konsortium PANC-STRAT

Reichert, M., Bakir, B., Moreira, L., Pitarresi, J.R., Feldmann, K., Simon, L., Suzuki, K., Maddipati, R., Rhim, A.D., Schlitter, A.M., Kriegsmann, M., Weichert, W., Wirth, M., Schuck, K., Schneider, G., Saur, D., Reynolds, A.B., Klein-Szanto, A.J., Pehlivanoglu, B., Memis, B., Adsay, N.V., Rustgi, A.K., 2018. Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev. Cell 45, 696-711.e8. doi.org/10.1016/j.devcel.2018.05.025

 

Konsortium SMOOSE

Tesch, R., Becker, C., Müller, M.P., Beck, M.E., Quambusch, L., Getlik, M., Lategahn, J., Uhlenbrock, N., Costa, F.N., Polêto, M.D., de Sena Murteira Pinheiro, P., Rodrigues, D.A., Sant’Anna, C.M., Ferreira, F.F., Verli, H., Fraga, C.A.M., Rauh, D., 2018. An Unusual Intramolecular Halogen Bond guides Conformational Selection. Angew. Chem. Int. Ed. Engl. doi.org/10.1002/anie.201804917

 

Juniorverbund SYMBOL-HF

Zhou, Q., Maleck, C., von Ungern-Sternberg, S.N.I., Neupane, B., Heinzmann, D., Marquardt, J., Duckheim, M., Scheckenbach, C., Stimpfle, F., Gawaz, M., Schreieck, J., Seizer, P., Gramlich, M., 2018. Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation. Circ Arrhythm Electrophysiol 11, e006242. doi.org/10.1161/CIRCEP.118.006242

Paone, C., Diofano, F., Park, D.-D., Rottbauer, W., Just, S., 2018. Genetics of Cardiovascular Disease: Fishing for Causality. Front. Cardiovasc. Med. 5. doi.org/10.3389/fcvm.2018.00060

Silbernagel, N., Walecki, M., Schäfer, M.K.-H., Kessler, M., Zobeiri, M., Rinné, S., Kiper, A.K., Komadowski, M.A., Vowinkel, K.S., Wemhöner, K., Fortmüller, L., Schewe, M., Dolga, A.M., Scekic-Zahirovic, J., Matschke, L.A., Culmsee, C., Baukrowitz, T., Monassier, L., Ullrich, N.D., Dupuis, L., Just, S., Budde, T., Fabritz, L., Decher, N., 2018. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. fj201800246R. doi.org/10.1096/fj.201800246R

 

Konsortium SysINFLAME

Frey-Jakobs, S., Hartberger, J.M., Fliegauf, M., Bossen, C., Wehmeyer, M.L., Neubauer, J.C., Bulashevska, A., Proietti, M., Fröbel, P., Nöltner, C., Yang, L., Rojas-Restrepo, J., Langer, N., Winzer, S., Engelhardt, K.R., Glocker, C., Pfeifer, D., Klein, A., Schäffer, A.A., Lagovsky, I., Lachover-Roth, I., Béziat, V., Puel, A., Casanova, J.-L., Fleckenstein, B., Weidinger, S., Kilic, S.S., Garty, B.-Z., Etzioni, A., Grimbacher, B., 2018. ZNF341 controls STAT3 expression and thereby immunocompetence. Sci Immunol 3. doi.org/10.1126/sciimmunol.aat4941

Béziat, V., Li, J., Lin, J.-X., Ma, C.S., Li, P., Bousfiha, A., Pellier, I., Zoghi, S., Baris, S., Keles, S., Gray, P., Du, N., Wang, Y., Zerbib, Y., Lévy, R., Leclercq, T., About, F., Lim, A.I., Rao, G., Payne, K., Pelham, S.J., Avery, D.T., Deenick, E.K., Pillay, B., Chou, J., Guery, R., Belkadi, A., Guérin, A., Migaud, M., Rattina, V., Ailal, F., Benhsaien, I., Bouaziz, M., Habib, T., Chaussabel, D., Marr, N., El-Benna, J., Grimbacher, B., Wargon, O., Bustamante, J., Boisson, B., Müller-Fleckenstein, I., Fleckenstein, B., Chandesris, M.-O., Titeux, M., Fraitag, S., Alyanakian, M.-A., Leruez-Ville, M., Picard, C., Meyts, I., Di Santo, J.P., Hovnanian, A., Somer, A., Ozen, A., Rezaei, N., Chatila, T.A., Abel, L., Leonard, W.J., Tangye, S.G., Puel, A., Casanova, J.-L., 2018. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol 3. doi.org/10.1126/sciimmunol.aat4956

 

Konsortium SysMedAlcoholism

Spechler, P.A., Allgaier, N., Chaarani, B., Whelan, R., Watts, R., Orr, C., Albaugh, M.D., D’Alberto, N., Higgins, S.T., Hudson, K.E., Mackey, S., Potter, A., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Martinot, M.-L.P., Nees, F., Orfanos, D.P., Paus, T., Smolka, M.N., Walter, H., Schumann, G., Althoff, R.R., Garavan, H., IMAGEN Consortium, 2018. The Initiation of Cannabis Use in Adolescence is Predicted by Sex-Specific Psychosocial and Neurobiological Features. Eur. J. Neurosci. doi.org/10.1111/ejn.13989

 

Konsortium SYSMED-NB

Correia, M.P., Stojanovic, A., Bauer, K., Juraeva, D., Tykocinski, L.-O., Lorenz, H.-M., Brors, B., Cerwenka, A., 2018. Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential. Proc. Natl. Acad. Sci. U.S.A. 115, E5980–E5989. doi.org/10.1073/pnas.1720564115

List of all e:Med publications

2018

Adam, I., Dewi, D.L., Mooiweer, J., Sadik, A., Mohapatra, S.R., Berdel, B., Keil, M., Sonner, J.K., Thedieck, K., Rose, A.J., Platten, M., Heiland, I., Trump, S., Opitz, C.A., 2018. Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation. OncoImmunology 0, 1–14. https://doi.org/10.1080/2162402X.2018.1486353

Aichler, M., Kunzke, T., Buck, A., Sun, N., Ackermann, M., Jonigk, D., Gaumann, A., Walch, A., 2018. Molecular similarities and differences from human pulmonary fibrosis and corresponding mouse model: MALDI imaging mass spectrometry in comparative medicine. Lab. Invest. 98, 141–149. https://doi.org/10.1038/labinvest.2017.110

Albaugh, M.D., Potter, A.S., 2018. The ventromedial prefrontal cortex: a putative locus for trait inattention. Neuropsychopharmacology. https://doi.org/10.1038/s41386-018-0193-7

Alhaddad, B., Schossig, A., Haack, T.B., Kovács-Nagy, R., Braunisch, M.C., Makowski, C., Senderek, J., Vill, K., Müller-Felber, W., Strom, T.M., Krabichler, B., Freisinger, P., Deshpande, C., Polster, T., Wolf, N.I., Desguerre, I., Wörmann, F., Rötig, A., Ahting, U., Kopajtich, R., Prokisch, H., Meitinger, T., Feichtinger, R.G., Mayr, J.A., Jungbluth, H., Hubmann, M., Zschocke, J., Distelmaier, F., Koch, J., 2018. PRUNE1 Deficiency: Expanding the Clinical and Genetic Spectrum. Neuropediatrics. https://doi.org/10.1055/s-0038-1661396

Ali, M., Ajore, R., Wihlborg, A.-K., Niroula, A., Swaminathan, B., Johnsson, E., Stephens, O.W., Morgan, G., Meissner, T., Turesson, I., Goldschmidt, H., Mellqvist, U.-H., Gullberg, U., Hansson, M., Hemminki, K., Nahi, H., Waage, A., Weinhold, N., Nilsson, B., 2018. The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression. Nat Commun 9, 1649. https://doi.org/10.1038/s41467-018-04082-2

Ansari, S.S., Sharma, A.K., Soni, H., Ali, D.M., Tews, B., König, R., Eibl, H., Berger, M.R., 2018. Induction of ER and mitochondrial stress by the alkylphosphocholine erufosine in oral squamous cell carcinoma cells. Cell Death Dis 9, 296. https://doi.org/10.1038/s41419-018-0342-2

Apweiler, R., Beissbarth, T., Berthold, M.R., Blüthgen, N., Burmeister, Y., Dammann, O., Deutsch, A., Feuerhake, F., Franke, A., Hasenauer, J., Hoffmann, S., Höfer, T., Jansen, P.L., Kaderali, L., Klingmüller, U., Koch, I., Kohlbacher, O., Kuepfer, L., Lammert, F., Maier, D., Pfeifer, N., Radde, N., Rehm, M., Roeder, I., Saez-Rodriguez, J., Sax, U., Schmeck, B., Schuppert, A., Seilheimer, B., Theis, F.J., Vera, J., Wolkenhauer, O., 2018. Whither systems medicine? Exp. Mol. Med. 50, e453. https://doi.org/10.1038/emm.2017.290

Aramillo Irizar, P., Schäuble, S., Esser, D., Groth, M., Frahm, C., Priebe, S., Baumgart, M., Hartmann, N., Marthandan, S., Menzel, U., Müller, J., Schmidt, S., Ast, V., Caliebe, A., König, R., Krawczak, M., Ristow, M., Schuster, S., Cellerino, A., Diekmann, S., Englert, C., Hemmerich, P., Sühnel, J., Guthke, R., Witte, O.W., Platzer, M., Ruppin, E., Kaleta, C., 2018. Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly. Nat Commun 9, 327. https://doi.org/10.1038/s41467-017-02395-2

Auer, F., Hammoud, Z., Ishkin, A., Pratt, D., Ideker, T., Kramer, F., Kelso, J., 2018. ndexr-an R package to interface with the network data exchange. Bioinformatics 34, 716–717. https://doi.org/10.1093/bioinformatics/btx683

B Schnabel, R., Pecen, L., Engler, D., Lucerna, M., Sellal, J.M., Ojeda, F.M., De Caterina, R., Kirchhof, P., 2018. Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes. Heart. https://doi.org/10.1136/heartjnl-2017-312569

Baron, U., Werner, J., Schildknecht, K., Schulze, J.J., Mulu, A., Liebert, U.-G., Sack, U., Speckmann, C., Gossen, M., Wong, R.J., Stevenson, D.K., Babel, N., Schürmann, D., Baldinger, T., Bacchetta, R., Grützkau, A., Borte, S., Olek, S., 2018. Epigenetic immune cell counting in human blood samples for immunodiagnostics. Sci Transl Med 10. https://doi.org/10.1126/scitranslmed.aan3508

Bauer, A.S., Nazarov, P.V., Giese, N.A., Beghelli, S., Heller, A., Greenhalf, W., Costello, E., Muller, A., Bier, M., Strobel, O., Hackert, T., Vallar, L., Scarpa, A., Büchler, M.W., Neoptolemos, J.P., Kreis, S., Hoheisel, J.D., 2018. Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer. Int. J. Cancer 142, 1010–1021. https://doi.org/10.1002/ijc.31087

Bauer, C., le Saux, O., Pomozi, V., Aherrahrou, R., Kriesen, R., Stölting, S., Liebers, A., Kessler, T., Schunkert, H., Erdmann, J., Aherrahrou, Z., 2018. Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation. Sci Rep 8, 5812. https://doi.org/10.1038/s41598-018-24228-y

Baurecht, H., Rühlemann, M.C., Rodríguez, E., Thielking, F., Harder, I., Erkens, A.-S., Stölzl, D., Ellinghaus, E., Hotze, M., Lieb, W., Wang, S., Heinsen-Groth, F.-A., Franke, A., Weidinger, S., 2018. Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration. J. Allergy Clin. Immunol. 141, 1668-1676.e16. https://doi.org/10.1016/j.jaci.2018.01.019

Bayard, F., Nymberg Thunell, C., Abé, C., Almeida, R., Banaschewski, T., Barker, G., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Martinot, M.-L.P., Nees, F., Orfanos, D.P., Paus, T., Poustka, L., Conrod, P., Stringaris, A., Struve, M., Penttilä, J., Kappel, V., Grimmer, Y., Fadai, T., van Noort, B., Smolka, M.N., Vetter, N.C., Walter, H., Whelan, R., Schumann, G., Petrovic, P., IMAGEN Consortium, 2018. Distinct brain structure and behavior related to ADHD and conduct disorder traits. Mol. Psychiatry. https://doi.org/10.1038/s41380-018-0202-6

Bazov, I., Sarkisyan, D., Kononenko, O., Watanabe, H., Yakovleva, T., Hansson, A.C., Sommer, W.H., Spanagel, R., Bakalkin, G., 2018. Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. Mol. Neurobiol. 55, 7049–7061. https://doi.org/10.1007/s12035-017-0844-4

Bedenk, B.T., Almeida-Corrêa, S., Jurik, A., Dedic, N., Grünecker, B., Genewsky, A.J., Kaltwasser, S.F., Riebe, C.J., Deussing, J.M., Czisch, M., Wotjak, C.T., 2018. Mn2+dynamics in manganese-enhanced MRI (MEMRI): Cav1.2 channel-mediated uptake and preferential accumulation in projection terminals. Neuroimage 169, 374–382. https://doi.org/10.1016/j.neuroimage.2017.12.054

Benito, E., Kerimoglu, C., Ramachandran, B., Pena-Centeno, T., Jain, G., Stilling, R.M., Islam, M.R., Capece, V., Zhou, Q., Edbauer, D., Dean, C., Fischer, A., 2018. RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment. Cell Rep 23, 546–554. https://doi.org/10.1016/j.celrep.2018.03.059

Béziat, V., Li, J., Lin, J.-X., Ma, C.S., Li, P., Bousfiha, A., Pellier, I., Zoghi, S., Baris, S., Keles, S., Gray, P., Du, N., Wang, Y., Zerbib, Y., Lévy, R., Leclercq, T., About, F., Lim, A.I., Rao, G., Payne, K., Pelham, S.J., Avery, D.T., Deenick, E.K., Pillay, B., Chou, J., Guery, R., Belkadi, A., Guérin, A., Migaud, M., Rattina, V., Ailal, F., Benhsaien, I., Bouaziz, M., Habib, T., Chaussabel, D., Marr, N., El-Benna, J., Grimbacher, B., Wargon, O., Bustamante, J., Boisson, B., Müller-Fleckenstein, I., Fleckenstein, B., Chandesris, M.-O., Titeux, M., Fraitag, S., Alyanakian, M.-A., Leruez-Ville, M., Picard, C., Meyts, I., Di Santo, J.P., Hovnanian, A., Somer, A., Ozen, A., Rezaei, N., Chatila, T.A., Abel, L., Leonard, W.J., Tangye, S.G., Puel, A., Casanova, J.-L., 2018. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol 3. https://doi.org/10.1126/sciimmunol.aat4956

Binz, T.M., Rietschel, L., Streit, F., Hofmann, M., Gehrke, J., Herdener, M., Quednow, B.B., Martin, N.G., Rietschel, M., Kraemer, T., Baumgartner, M.R., 2018. Endogenous cortisol in keratinized matrices: Systematic determination of baseline cortisol levels in hair and the influence of sex, age and hair color. Forensic Sci. Int. 284, 33–38. https://doi.org/10.1016/j.forsciint.2017.12.032

Blazquez-Navarro, A., Dang-Heine, C., Wittenbrink, N., Bauer, C., Wolk, K., Sabat, R., Westhoff, T.H., Sawitzki, B., Reinke, P., Thomusch, O., Hugo, C., Or-Guil, M., Babel, N., 2018a. BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study. EBioMedicine. https://doi.org/10.1016/j.ebiom.2018.07.017

Blazquez-Navarro, A., Schachtner, T., Stervbo, U., Sefrin, A., Stein, M., Westhoff, T.H., Reinke, P., Klipp, E., Babel, N., Neumann, A.U., Or-Guil, M., 2018b. Differential T cell response against BK virus regulatory and structural antigens: A viral dynamics modelling approach. PLoS Comput. Biol. 14, e1005998. https://doi.org/10.1371/journal.pcbi.1005998

Bonetti, D., Longhese, M.P., 2018. Analysis of De Novo Telomere Addition by Southern Blot. Methods Mol. Biol. 1672, 363–373. https://doi.org/10.1007/978-1-4939-7306-4_25

Brainstorm Consortium, Anttila, V., Bulik-Sullivan, B., …., Nöthen, M.M., ..., Muller-Myhsok, B., Schreiber, S., ... Gasser, T., Gibbs, R., Heutink, P., …., Banaschewski, T., …, Schulze, T.G…, Cichon, S., Mühleisen, T.W., Degenhardt, F., …., Forstner, A.J., Streit, F., Baune, B.T., …., Dichgans, M., et al.,2018. Analysis of shared heritability in common disorders of the brain. Science 360. doi.org/10.1126/science.aap8757

Braun, D.M., Chung, I., Kepper, N., Deeg, K.I., Rippe, K., 2018. TelNet - a database for human and yeast genes involved in telomere maintenance. BMC Genet. 19, 32. https://doi.org/10.1186/s12863-018-0617-8

Braun, U., Schaefer, A., Betzel, R.F., Tost, H., Meyer-Lindenberg, A., Bassett, D.S., 2018. From Maps to Multi-dimensional Network Mechanisms of Mental Disorders. Neuron 97, 14–31. https://doi.org/10.1016/j.neuron.2017.11.007

Braunisch, M.C., Gallwitz, H., Abicht, A., Diebold, I., Holinski-Feder, E., Van Maldergem, L., Lammens, M., Kovács-Nagy, R., Alhaddad, B., Strom, T.M., Meitinger, T., Senderek, J., Rudnik-Schöneborn, S., Haack, T.B., 2018. Extension of the phenotype of biallelic loss-of-function mutations in SLC25A46 to the severe form of pontocerebellar hypoplasia type I. Clin. Genet. 93, 255–265. https://doi.org/10.1111/cge.13084

Breunig, C., Erdem, N., Bott, A., Greiwe, J.F., Reinz, E., Bernhardt, S., Giacomelli, C., Wachter, A., Kanthelhardt, E.J., Beißbarth, T., Vetter, M., Wiemann, S., 2018. TGFβ1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer. Mol Oncol 12, 1447–1463. https://doi.org/10.1002/1878-0261.12355

Broccoli, L., Uhrig, S., von Jonquieres, G., Schönig, K., Bartsch, D., Justice, N.J., Spanagel, R., Sommer, W.H., Klugmann, M., Hansson, A.C., 2018. Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior. Psychopharmacology (Berl.) 235, 1821–1833. https://doi.org/10.1007/s00213-018-4908-6

Brockmann, S.J., Freischmidt, A., Oeckl, P., Müller, K., Ponna, S.K., Helferich, A.M., Paone, C., Reinders, J., Kojer, K., Orth, M., Jokela, M., Auranen, M., Udd, B., Hermann, A., Danzer, K.M., Lichtner, P., Walther, P., Ludolph, A.C., Andersen, P.M., Otto, M., Kursula, P., Just, S., Weishaupt, J.H., 2018. CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum. Mol. Genet. 27, 706–715. https://doi.org/10.1093/hmg/ddx436

Bruyer, A., Maes, K., Herviou, L., Kassambara, A., Seckinger, A., Cartron, G., Rème, T., Robert, N., Requirand, G., Boireau, S., Müller-Tidow, C., Veyrune, J.-L., Vincent, L., Bouhya, S., Goldschmidt, H., Vanderkerken, K., Hose, D., Klein, B., De Bruyne, E., Moreaux, J., 2018. DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells. Br. J. Cancer 118, 1062–1073. https://doi.org/10.1038/s41416-018-0025-x

Campo, C., da Silva Filho, M.I., Weinhold, N., Mahmoudpour, S.H., Goldschmidt, H., Hemminki, K., Merz, M., Försti, A., 2018. Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients. Hematol Oncol 36, 232–237. https://doi.org/10.1002/hon.2391

Cao, Z., Bennett, M., Orr, C., Icke, I., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Nees, F., Orfanos, D.P., Paus, T., Poustka, L., Hohmann, S., Fröhner, J.H., Smolka, M.N., Walter, H., Schumann, G., Whelan, R., IMAGEN Consortium, 2018. Mapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task. Hum Brain Mapp. https://doi.org/10.1002/hbm.24370

Chang, H., Hoshina, N., Zhang, C., Ma, Y., Cao, H., Wang, Y., Wu, D.-D., Bergen, S.E., Landén, M., Hultman, C.M., Preisig, M., Kutalik, Z., Castelao, E., Grigoroiu-Serbanescu, M., Forstner, A.J., Strohmaier, J., Hecker, J., Schulze, T.G., Müller-Myhsok, B., Reif, A., Mitchell, P.B., Martin, N.G., Schofield, P.R., Cichon, S., Nöthen, M.M., Swedish Bipolar Study Group, MooDS Bipolar Consortium, Walter, H., Erk, S., Heinz, A., Amin, N., van Duijn, C.M., Meyer-Lindenberg, A., Tost, H., Xiao, X., Yamamoto, T., Rietschel, M., Li, M., 2018. The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders. Mol. Psychiatry 23, 400–412. https://doi.org/10.1038/mp.2016.231

Chapuy, B., Stewart, C., Dunford, A.J., Kim, J., Kamburov, A., Redd, R.A., Lawrence, M.S., Roemer, M.G.M., Li, A.J., Ziepert, M., Staiger, A.M., Wala, J.A., Ducar, M.D., Leshchiner, I., Rheinbay, E., Taylor-Weiner, A., Coughlin, C.A., Hess, J.M., Pedamallu, C.S., Livitz, D., Rosebrock, D., Rosenberg, M., Tracy, A.A., Horn, H., van Hummelen, P., Feldman, A.L., Link, B.K., Novak, A.J., Cerhan, J.R., Habermann, T.M., Siebert, R., Rosenwald, A., Thorner, A.R., Meyerson, M.L., Golub, T.R., Beroukhim, R., Wulf, G.G., Ott, G., Rodig, S.J., Monti, S., Neuberg, D.S., Loeffler, M., Pfreundschuh, M., Trümper, L., Getz, G., Shipp, M.A., 2018. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat. Med. 24, 679–690. https://doi.org/10.1038/s41591-018-0016-8

Charif, M., Nasca, A., Thompson, K., Gerber, S., Makowski, C., Mazaheri, N., Bris, C., Goudenège, D., Legati, A., Maroofian, R., Shariati, G., Lamantea, E., Hopton, S., Ardissone, A., Moroni, I., Giannotta, M., Siegel, C., Strom, T.M., Prokisch, H., Vignal-Clermont, C., Derrien, S., Zanlonghi, X., Kaplan, J., Hamel, C.P., Leruez, S., Procaccio, V., Bonneau, D., Reynier, P., White, F.E., Hardy, S.A., Barbosa, I.A., Simpson, M.A., Vara, R., Perdomo Trujillo, Y., Galehdari, H., Deshpande, C., Haack, T.B., Rozet, J.-M., Taylor, R.W., Ghezzi, D., Amati-Bonneau, P., Lenaers, G., 2018. Neurologic Phenotypes Associated With Mutations in RTN4IP1 (OPA10) in Children and Young Adults. JAMA Neurol 75, 105–113. https://doi.org/10.1001/jamaneurol.2017.2065

Charlet, K., Rosenthal, A., Lohoff, F.W., Heinz, A., Beck, A., 2018. Imaging resilience and recovery in alcohol dependence. Addiction. https://doi.org/10.1111/add.14259

Chattopadhyay, S., Thomsen, H., da Silva Filho, M.I., Weinhold, N., Hoffmann, P., Nöthen, M.M., Marina, A., Jöckel, K.-H., Schmidt, B., Pechlivanis, S., Langer, C., Goldschmidt, H., Hemminki, K., Försti, A., 2018a. Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study. Molecular Medicine 24, 30. https://doi.org/10.1186/s10020-018-0031-8

Chattopadhyay, S., Yu, H., Sud, A., Sundquist, J., Försti, A., Hemminki, A., Hemminki, K., 2018b. Multiple myeloma: family history and mortality in second primary cancers. Blood Cancer J 8, 75. https://doi.org/10.1038/s41408-018-0108-1

Chen, J., Cao, H., Meyer-Lindenberg, A., Schwarz, E., 2018. Male increase in brain gene expression variability is linked to genetic risk for schizophrenia. Transl Psychiatry 8, 140. https://doi.org/10.1038/s41398-018-0200-0

Chudasama, P., Mughal, S.S., Sanders, M.A., Hübschmann, D., Chung, I., Deeg, K.I., Wong, S.-H., Rabe, S., Hlevnjak, M., Zapatka, M., Ernst, A., Kleinheinz, K., Schlesner, M., Sieverling, L., Klink, B., Schröck, E., Hoogenboezem, R.M., Kasper, B., Heilig, C.E., Egerer, G., Wolf, S., von Kalle, C., Eils, R., Stenzinger, A., Weichert, W., Glimm, H., Gröschel, S., Kopp, H.-G., Omlor, G., Lehner, B., Bauer, S., Schimmack, S., Ulrich, A., Mechtersheimer, G., Rippe, K., Brors, B., Hutter, B., Renner, M., Hohenberger, P., Scholl, C., Fröhling, S., 2018. Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun 9, 144. https://doi.org/10.1038/s41467-017-02602-0

Clemm von Hohenberg, C., Weber-Fahr, W., Lebhardt, P., Ravi, N., Braun, U., Gass, N., Becker, R., Sack, M., Cosa Linan, A., Gerchen, M.F., Reinwald, J.R., Oettl, L.-L., Meyer-Lindenberg, A., Vollmayr, B., Kelsch, W., Sartorius, A., 2018. Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression. Transl Psychiatry 8, 68. https://doi.org/10.1038/s41398-018-0121-y

Comes, A.L., Papiol, S., Mueller, T., Geyer, P.E., Mann, M., Schulze, T.G., 2018. Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future. Transl Psychiatry 8, 160. https://doi.org/10.1038/s41398-018-0219-2

Corominas, J., Klein, M., Zayats, T., Rivero, O., Ziegler, G.C., Pauper, M., Neveling, K., Poelmans, G., Jansch, C., Svirin, E., Geissler, J., Weber, H., Reif, A., Arias Vasquez, A., Galesloot, T.E., Kiemeney, L.A.L.M., Buitelaar, J.K., Ramos-Quiroga, J.-A., Cormand, B., Ribasés, M., Hveem, K., Gabrielsen, M.E., Hoffmann, P., Cichon, S., Haavik, J., Johansson, S., Jacob, C.P., Romanos, M., Franke, B., Lesch, K.-P., 2018. Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing. Mol. Psychiatry. https://doi.org/10.1038/s41380-018-0210-6

Correia, M.P., Stojanovic, A., Bauer, K., Juraeva, D., Tykocinski, L.-O., Lorenz, H.-M., Brors, B., Cerwenka, A., 2018. Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential. Proc. Natl. Acad. Sci. U.S.A. 115, E5980–E5989. https://doi.org/10.1073/pnas.1720564115

Culverhouse, R.C., Saccone, N.L., Horton, A.C., Ma, Y., Anstey, K.J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H.L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K.J., Mandelli, L., Middeldorp, C.M., Olié, E., Villafuerte, S., Air, T.M., Araya, R., Bowes, L., Burns, R., Byrne, E.M., Coffey, C., Coventry, W.L., Gawronski, K. a. B., Glei, D., Hatzimanolis, A., Hottenga, J.-J., Jaussent, I., Jawahar, C., Jennen-Steinmetz, C., Kramer, J.R., Lajnef, M., Little, K., Zu Schwabedissen, H.M., Nauck, M., Nederhof, E., Petschner, P., Peyrot, W.J., Schwahn, C., Sinnamon, G., Stacey, D., Tian, Y., Toben, C., Van der Auwera, S., Wainwright, N., Wang, J.-C., Willemsen, G., Anderson, I.M., Arolt, V., Åslund, C., Bagdy, G., Baune, B.T., Bellivier, F., Boomsma, D.I., Courtet, P., Dannlowski, U., de Geus, E.J.C., Deakin, J.F.W., Easteal, S., Eley, T., Fergusson, D.M., Goate, A.M., Gonda, X., Grabe, H.J., Holzman, C., Johnson, E.O., Kennedy, M., Laucht, M., Martin, N.G., Munafò, M.R., Nilsson, K.W., Oldehinkel, A.J., Olsson, C.A., Ormel, J., Otte, C., Patton, G.C., Penninx, B.W.J.H., Ritchie, K., Sarchiapone, M., Scheid, J.M., Serretti, A., Smit, J.H., Stefanis, N.C., Surtees, P.G., Völzke, H., Weinstein, M., Whooley, M., Nurnberger, J.I., Breslau, N., Bierut, L.J., 2018. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol. Psychiatry 23, 133–142. https://doi.org/10.1038/mp.2017.44

Cun, Y., Yang, T.-P., Achter, V., Lang, U., Peifer, M., 2018. Copy-number analysis and inference of subclonal populations in cancer genomes using Sclust. Nature Protocols 13, 1488–1501. https://doi.org/10.1038/nprot.2018.033

D’Alberto, N., Chaarani, B., Orr, C.A., Spechler, P.A., Albaugh, M.D., Allgaier, N., Wonnell, A., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Conrod, P.J., Desrivieres, S., Flor, H., Fröhner, J.H., Frouin, V., Gowland, P.A., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Robbins, T.W., Smolka, M.N., Walter, H., Wehlan, R., Schumann, G., Potter, A.S., Garavanh, H., 2018. Individual differences in stop-related activity are inflated by the adaptive algorithm in the stop signal task. - PubMed - NCBI. Human Brain Mapping.

de Boni, L., Gasparoni, G., Haubenreich, C., Tierling, S., Schmitt, I., Peitz, M., Koch, P., Walter, J., Wüllner, U., Brüstle, O., 2018. DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling. Clin Epigenetics 10, 13. https://doi.org/10.1186/s13148-018-0440-0

Dedic, Nina, Chen, A., Deussing, J.M., 2018a. The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response. Curr Mol Pharmacol 11, 4–31. https://doi.org/10.2174/1874467210666170302104053

Dedic, Nina, Kühne, C., Jakovcevski, M., Hartmann, J., Genewsky, A.J., Gomes, K.S., Anderzhanova, E., Pöhlmann, M.L., Chang, S., Kolarz, A., Vogl, A.M., Dine, J., Metzger, M.W., Schmid, B., Almada, R.C., Ressler, K.J., Wotjak, C.T., Grinevich, V., Chen, A., Schmidt, M.V., Wurst, W., Refojo, D., Deussing, J.M., 2018b. Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat. Neurosci. 21, 803–807. https://doi.org/10.1038/s41593-018-0151-z

Dedic, N., Pöhlmann, M.L., Richter, J.S., Mehta, D., Czamara, D., Metzger, M.W., Dine, J., Bedenk, B.T., Hartmann, J., Wagner, K.V., Jurik, A., Almli, L.M., Lori, A., Moosmang, S., Hofmann, F., Wotjak, C.T., Rammes, G., Eder, M., Chen, A., Ressler, K.J., Wurst, W., Schmidt, M.V., Binder, E.B., Deussing, J.M., 2018. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. Mol. Psychiatry 23, 533–543. https://doi.org/10.1038/mp.2017.133

Desbenoit, N., Walch, A., Spengler, B., Brunelle, A., Römpp, A., 2018. Correlative mass spectrometry imaging, applying time-of-flight secondary ion mass spectrometry and atmospheric pressure matrix-assisted laser desorption/ionization to a single tissue section. Rapid Commun. Mass Spectrom. 32, 159–166. https://doi.org/10.1002/rcm.8022

Deussing, J.M., Arzt, E., 2018. P2X7 Receptor: A Potential Therapeutic Target for Depression? Trends Mol Med 24, 736–747. https://doi.org/10.1016/j.molmed.2018.07.005

Deussing, J.M., Chen, A., 2018. The Corticotropin-Releasing Factor Family: Physiology of the Stress Response. Physiol. Rev. 98, 2225–2286. https://doi.org/10.1152/physrev.00042.2017

Dietert, K., Nouailles, G., Gutbier, B., Reppe, K., Berger, S., Jiang, X., Schauer, A.E., Hocke, A.C., Herold, S., Slevogt, H., Witzenrath, M., Suttorp, N., Gruber, A.D., 2018. Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia. Am. J. Respir. Cell Mol. Biol. 58, 440–448. https://doi.org/10.1165/rcmb.2017-0337MA

Dietrich, S., Oleś, M., Lu, J., Sellner, L., Anders, S., Velten, B., Wu, B., Hüllein, J., da Silva Liberio, M., Walther, T., Wagner, L., Rabe, S., Ghidelli-Disse, S., Bantscheff, M., Oleś, A.K., Słabicki, M., Mock, A., Oakes, C.C., Wang, S., Oppermann, S., Lukas, M., Kim, V., Sill, M., Benner, A., Jauch, A., Sutton, L.A., Young, E., Rosenquist, R., Liu, X., Jethwa, A., Lee, K.S., Lewis, J., Putzker, K., Lutz, C., Rossi, D., Mokhir, A., Oellerich, T., Zirlik, K., Herling, M., Nguyen-Khac, F., Plass, C., Andersson, E., Mustjoki, S., von Kalle, C., Ho, A.D., Hensel, M., Dürig, J., Ringshausen, I., Zapatka, M., Huber, W., Zenz, T., 2018. Drug-perturbation-based stratification of blood cancer. J. Clin. Invest. 128, 427–445. https://doi.org/10.1172/JCI93801

Do, K.T., Wahl, S., Raffler, J., Molnos, S., Laimighofer, M., Adamski, J., Suhre, K., Strauch, K., Peters, A., Gieger, C., Langenberg, C., Stewart, I.D., Theis, F.J., Grallert, H., Kastenmüller, G., Krumsiek, J., 2018. Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies. Metabolomics 14, 128. https://doi.org/10.1007/s11306-018-1420-2

Donaghey, J., Thakurela, S., Charlton, J., Chen, J.S., Smith, Z.D., Gu, H., Pop, R., Clement, K., Stamenova, E.K., Karnik, R., Kelley, D.R., Gifford, C.A., Cacchiarelli, D., Rinn, J.L., Gnirke, A., Ziller, M.J., Meissner, A., 2018. Genetic determinants and epigenetic effects of pioneer-factor occupancy. Nat. Genet. 50, 250–258. https://doi.org/10.1038/s41588-017-0034-3

Drapkin, B.J., George, J., Christensen, C.L., Mino-Kenudson, M., Dries, R., Sundaresan, T., Phat, S., Myers, D.T., Zhong, J., Igo, P., Hazar-Rethinam, M.H., Licausi, J.A., Gomez-Caraballo, M., Kem, M., Jani, K.N., Azimi, R., Abedpour, N., Menon, R., Lakis, S., Heist, R.S., Büttner, R., Haas, S., Sequist, L.V., Shaw, A.T., Wong, K.-K., Hata, A.N., Toner, M., Maheswaran, S., Haber, D.A., Peifer, M., Dyson, N., Thomas, R.K., Farago, A.F., 2018. Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts. Cancer Discov 8, 600–615. https://doi.org/10.1158/2159-8290.CD-17-0935

Dvornikov, D., Schneider, M.A., Ohse, S., Szczygieł, M., Titkova, I., Rosenblatt, M., Muley, T., Warth, A., Herth, F.J., Dienemann, H., Thomas, M., Timmer, J., Schilling, M., Busch, H., Boerries, M., Meister, M., Klingmüller, U., 2018. Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response. Sci Rep 8, 9517. https://doi.org/10.1038/s41598-018-27912-1

Egg, D., Schwab, C., Gabrysch, A., Arkwright, P.D., Cheesman, E., Giulino-Roth, L., Neth, O., Snapper, S., Okada, S., Moutschen, M., Delvenne, P., Pecher, A.-C., Wolff, D., Kim, Y.-J., Seneviratne, S., Kim, K.-M., Kang, J.-M., Ojaimi, S., McLean, C., Warnatz, K., Seidl, M., Grimbacher, B., 2018. Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers. Front Immunol 9, 2012. https://doi.org/10.3389/fimmu.2018.02012

Erdmann, J., Kessler, T., Munoz Venegas, L., Schunkert, H., 2018a. A decade of genome-wide association studies for coronary artery disease: The challenges ahead. Cardiovasc Res. https://doi.org/10.1093/cvr/cvy084

Erdmann, J., Kessler, T., Munoz Venegas, L., Schunkert, H., 2018b. A decade of genome-wide association studies for coronary artery disease: the challenges ahead. Cardiovasc. Res. 114, 1241–1257. https://doi.org/10.1093/cvr/cvy084

Fangmann, D., Theismann, E.-M., Türk, K., Schulte, D.M., Relling, I., Hartmann, K., Keppler, J.K., Knipp, J.-R., Rehman, A., Heinsen, F.-A., Franke, A., Lenk, L., Freitag-Wolf, S., Appel, E., Gorb, S., Brenner, C., Seegert, D., Waetzig, G.H., Rosenstiel, P., Schreiber, S., Schwarz, K., Laudes, M., 2018. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans. Diabetes Care 41, 398–405. https://doi.org/10.2337/dc17-1967

Fassoni, A.C., Baldow, C., Roeder, I., Glauche, I., 2018. Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: A simulation study based on phase 3 trial data. Haematologica. https://doi.org/10.3324/haematol.2018.194522

Feist, M., Schwarzfischer, P., Heinrich, P., Sun, X., Kemper, J., von Bonin, F., Perez-Rubio, P., Taruttis, F., Rehberg, T., Dettmer, K., Gronwald, W., Reinders, J., Engelmann, J.C., Dudek, J., Klapper, W., Trümper, L., Spang, R., Oefner, P.J., Kube, D., 2018. Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression. Nat Commun 9, 1514. https://doi.org/10.1038/s41467-018-03803-x

Felix, K., Hinz, U., Dobiasch, S., Hackert, T., Bergmann, F., Neumüller, M., Gronowitz, S., Bergqvist, M., Strobel, O., 2018. Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer. Pancreas 47, 72–79. https://doi.org/10.1097/MPA.0000000000000966

Ferrario, P.G., König, I.R., 2018. Transferring entropy to the realm of GxG interactions. Brief. Bioinformatics 19, 136–147. https://doi.org/10.1093/bib/bbw086

Fliegauf, M., Grimbacher, B., 2018. NFkB mutations in humans: The devil is in the details. J. Allergy Clin. Immunol. https://doi.org/10.1016/j.jaci.2018.06.050

Foo, J.C., Streit, F., Treutlein, J., Ripke, S., Witt, S.H., Strohmaier, J., Degenhardt, F., Forstner, A.J., Hoffmann, P., Soyka, M., Dahmen, N., Scherbaum, N., Wodarz, N., Heilmann-Heimbach, S., Herms, S., Cichon, S., Preuss, U., Gaebel, W., Ridinger, M., Hoffmann, S., Schulze, T.G., Maier, W., Zill, P., Müller-Myhsok, B., Ising, M., Lucae, S., Nöthen, M.M., Mann, K., Kiefer, F., Rietschel, M., Frank, J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 2018. Shared genetic etiology between alcohol dependence and major depressive disorder. Psychiatr. Genet. 28, 66–70. https://doi.org/10.1097/YPG.0000000000000201

Frey, N., Venturelli, S., Zender, L., Bitzer, M., 2018. Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics. Nat Rev Gastroenterol Hepatol 15, 81–95. https://doi.org/10.1038/nrgastro.2017.146

Frey-Jakobs, S., Hartberger, J.M., Fliegauf, M., Bossen, C., Wehmeyer, M.L., Neubauer, J.C., Bulashevska, A., Proietti, M., Fröbel, P., Nöltner, C., Yang, L., Rojas-Restrepo, J., Langer, N., Winzer, S., Engelhardt, K.R., Glocker, C., Pfeifer, D., Klein, A., Schäffer, A.A., Lagovsky, I., Lachover-Roth, I., Béziat, V., Puel, A., Casanova, J.-L., Fleckenstein, B., Weidinger, S., Kilic, S.S., Garty, B.-Z., Etzioni, A., Grimbacher, B., 2018. ZNF341 controls STAT3 expression and thereby immunocompetence. Sci Immunol 3. https://doi.org/10.1126/sciimmunol.aat4941

Fulterer, A., Andlauer, T.F.M., Ender, A., Maglione, M., Eyring, K., Woitkuhn, J., Lehmann, M., Matkovic-Rachid, T., Geiger, J.R.P., Walter, A.M., Nagel, K.I., Sigrist, S.J., 2018. Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses. Cell Rep 23, 1259–1274. https://doi.org/10.1016/j.celrep.2018.03.126

Fussi, N., Höllerhage, M., Chakroun, T., Nykänen, N.-P., Rösler, T.W., Koeglsperger, T., Wurst, W., Behrends, C., Höglinger, G.U., 2018. Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy. Cell Death Dis 9, 757. https://doi.org/10.1038/s41419-018-0816-2

Ganzinger, M., Gietzelt, M., Karmen, C., Flores, B., Knaup, P., 2018. Implementing Systems Medicine: A Medical Informatics Perspective. Stud Health Technol Inform 247, 875–879.

Gao, F., Thiebes, S., Sunyaev, A., 2018. Rethinking the Meaning of Cloud Computing for Health Care: A Taxonomic Perspective and Future Research Directions. J. Med. Internet Res. 20, e10041. https://doi.org/10.2196/10041

Garrett, L., Becker, L., Rozman, J., Puk, O., Stoeger, T., Yildirim, A.Ö., Bohla, A., Eickelberg, O., Hans, W., Prehn, C., Adamski, J., Klopstock, T., Rácz, I., Zimmer, A., Klingenspor, M., Fuchs, H., Gailus-Durner, V., Wurst, W., Hrabě de Angelis, M., Graw, J., Hölter, S.M., 2018. Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice. Mol. Neurobiol. 55, 4580–4595. https://doi.org/10.1007/s12035-017-0659-3

Geiger, L.S., Moessnang, C., Schäfer, A., Zang, Z., Zangl, M., Cao, H., van Raalten, T.R., Meyer-Lindenberg, A., Tost, H., 2018. Novelty modulates human striatal activation and prefrontal-striatal effective connectivity during working memory encoding. Brain Struct Funct. https://doi.org/10.1007/s00429-018-1679-0

George, J., Walter, V., Peifer, M., Alexandrov, L.B., Seidel, D., Leenders, F., Maas, L., Müller, C., Dahmen, I., Delhomme, T.M., Ardin, M., Leblay, N., Byrnes, G., Sun, R., De Reynies, A., McLeer-Florin, A., Bosco, G., Malchers, F., Menon, R., Altmüller, J., Becker, C., Nürnberg, P., Achter, V., Lang, U., Schneider, P.M., Bogus, M., Soloway, M.G., Wilkerson, M.D., Cun, Y., McKay, J.D., Moro-Sibilot, D., Brambilla, C.G., Lantuejoul, S., Lemaitre, N., Soltermann, A., Weder, W., Tischler, V., Brustugun, O.T., Lund-Iversen, M., Helland, Å., Solberg, S., Ansén, S., Wright, G., Solomon, B., Roz, L., Pastorino, U., Petersen, I., Clement, J.H., Sänger, J., Wolf, J., Vingron, M., Zander, T., Perner, S., Travis, W.D., Haas, S.A., Olivier, M., Foll, M., Büttner, R., Hayes, D.N., Brambilla, E., Fernandez-Cuesta, L., Thomas, R.K., 2018. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. Nat Commun 9, 1048. https://doi.org/10.1038/s41467-018-03099-x

Glaab, E., 2018. Computational systems biology approaches for Parkinson’s disease. Cell Tissue Res. 373, 91–109. https://doi.org/10.1007/s00441-017-2734-5

Glauche, I., Kuhn, M., Baldow, C., Schulze, P., Rothe, T., Liebscher, H., Roy, A., Wang, X., Roeder, I., 2018. Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison. Sci Rep 8, 12330. https://doi.org/10.1038/s41598-018-29923-4

Gonzalez, D.A., Jia, T., Pinzón, J.H., Acevedo, S.F., Ojelade, S.A., Xu, B., Tay, N., Desrivières, S., Hernandez, J.L., Banaschewski, T., Büchel, C., Bokde, A.L.W., Conrod, P.J., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P.A., Heinz, A., Ittermann, B., Lathrop, M., Martinot, J.-L., Paus, T., Smolka, M.N., IMAGEN Consortium, Rodan, A.R., Schumann, G., Rothenfluh, A., 2018. The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Mol. Psychiatry 23, 621–628. https://doi.org/10.1038/mp.2017.112

Gregor, A., Sadleir, L.G., Asadollahi, R., Azzarello-Burri, S., Battaglia, A., Ousager, L.B., Boonsawat, P., Bruel, A.-L., Buchert, R., Calpena, E., Cogné, B., Dallapiccola, B., Distelmaier, F., Elmslie, F., Faivre, L., Haack, T.B., Harrison, V., Henderson, A., Hunt, D., Isidor, B., Joset, P., Kumada, S., Lachmeijer, A.M.A., Lees, M., Lynch, S.A., Martinez, F., Matsumoto, N., McDougall, C., Mefford, H.C., Miyake, N., Myers, C.T., Moutton, S., Nesbitt, A., Novelli, A., Orellana, C., Rauch, A., Rosello, M., Saida, K., Santani, A.B., Sarkar, A., Scheffer, I.E., Shinawi, M., Steindl, K., Symonds, J.D., Zackai, E.H., University of Washington Center for Mendelian Genomics, DDD Study, Reis, A., Sticht, H., Zweier, C., 2018. De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder. Am. J. Hum. Genet. 103, 305–316. https://doi.org/10.1016/j.ajhg.2018.07.003

Gu, C., Holman, C., Sompallae, R., Jing, X., Tomasson, M., Hose, D., Seckinger, A., Zhan, F., Tricot, G., Goldschmidt, H., Yang, Y., Janz, S., 2018. Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome. Blood Cancer J 8, 22. https://doi.org/10.1038/s41408-018-0060-0

Guggenmos, M., Scheel, M., Sekutowicz, M., Garbusow, M., Sebold, M., Sommer, C., Charlet, K., Beck, A., Wittchen, H.-U., Zimmermann, U.S., Smolka, M.N., Heinz, A., Sterzer, P., Schmack, K., 2018. Decoding diagnosis and lifetime consumption in alcohol dependence from grey-matter pattern information. Acta Psychiatr Scand 137, 252–262. https://doi.org/10.1111/acps.12848

Gunes, C., Avila, A.I., Rudolph, K.L., 2018. Telomeres in cancer. Differentiation 99, 41–50. https://doi.org/10.1016/j.diff.2017.12.004

Gutbier, B., Neuhauß, A.-K., Reppe, K., Ehrler, C., Santel, A., Kaufmann, J., Scholz, M., Weissmann, N., Morawietz, L., Mitchell, T.J., Aliberti, S., Hippenstiel, S., Suttorp, N., Witzenrath, M., CAPNETZ and PROGRESS Study Groups ‡, 2018a. Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia. Am. J. Respir. Crit. Care Med. 198, 220–231. https://doi.org/10.1164/rccm.201708-1733OC

Gutbier, B., Schönrock, S.M., Ehrler, C., Haberberger, R., Dietert, K., Gruber, A.D., Kummer, W., Michalick, L., Kuebler, W.M., Hocke, A.C., Szymanski, K., Letsiou, E., Lüth, A., Schumacher, F., Kleuser, B., Mitchell, T.J., Bertrams, W., Schmeck, B., Treue, D., Klauschen, F., Bauer, T.T., Tönnies, M., Weissmann, N., Hippenstiel, S., Suttorp, N., Witzenrath, M., CAPNETZ Study Group, 2018b. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Crit. Care Med. https://doi.org/10.1097/CCM.0000000000002916

Hansson, A.C., Gründer, G., Hirth, N., Noori, H.R., Spanagel, R., Sommer, W.H., 2018a. Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. Neurosci Biobehav Rev. https://doi.org/10.1016/j.neubiorev.2018.09.010

Hansson, A.C., Koopmann, A., Uhrig, S., Bühler, S., Domi, E., Kiessling, E., Ciccocioppo, R., Froemke, R.C., Grinevich, V., Kiefer, F., Sommer, W.H., Vollstädt-Klein, S., Spanagel, R., 2018b. Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans. Neuropsychopharmacology 43, 1235–1246. https://doi.org/10.1038/npp.2017.257

Häsler, R., Kautz, C., Rehman, A., Podschun, R., Gassling, V., Brzoska, P., Sherlock, J., Gräsner, J.-T., Hoppenstedt, G., Schubert, S., Ferlinz, A., Lieb, W., Laudes, M., Heinsen, F.-A., Scholz, J., Harmsen, D., Franke, A., Eisend, S., Kunze, T., Fickenscher, H., Ott, S., Rosenstiel, P., Schreiber, S., 2018. The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany. Microbiome 6, 37. https://doi.org/10.1186/s40168-018-0414-7

He, Y., Thriene, K., Boerries, M., Hausser, I., Franzke, C.-W., Busch, H., Dengjel, J., Has, C., 2018. Constitutional absence of epithelial integrin α3 impacts the composition of the cellular microenvironment of ILNEB keratinocytes. Matrix Biology. https://doi.org/10.1016/j.matbio.2018.07.001

Heermann, T., Garrett, L., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Graw, J., Hölter, S.M., 2018. Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice. Mol. Neurobiol. https://doi.org/10.1007/s12035-018-1365-5

Heiland, D.H., Gaebelein, A., Börries, M., Wörner, J., Pompe, N., Franco, P., Heynckes, S., Bartholomae, M., hAilín, D.Ó., Carro, M.S., Prinz, M., Weber, S., Mader, I., Delev, D., Schnell, O., 2018. Microenvironment-Derived Regulation of HIF Signaling Drives Transcriptional Heterogeneity in Glioblastoma Multiforme. Mol. Cancer Res. 16, 655–668. https://doi.org/10.1158/1541-7786.MCR-17-0680

Heining, C., Horak, P., Uhrig, S., Codo, P.L., Klink, B., Hutter, B., Fröhlich, M., Bonekamp, D., Richter, D., Steiger, K., Penzel, R., Endris, V., Ehrenberg, K.R., Frank, S., Kleinheinz, K., Toprak, U.H., Schlesner, M., Mandal, R., Schulz, L., Lambertz, H., Fetscher, S., Bitzer, M., Malek, N.P., Horger, M.S., Giese, N.A., Strobel, O., Hackert, T., Springfeld, C., Feuerbach, L., Bergmann, F., Schröck, E., von Kalle, C., Weichert, W., Scholl, C., Ball, C.R., Stenzinger, A., Brors, B., Fröhling, S., Glimm, H., 2018. NRG1 Fusions in KRAS Wild-type Pancreatic Cancer. Cancer Discov. https://doi.org/10.1158/2159-8290.CD-18-0036

Helferich, A.M., Brockmann, S.J., Reinders, J., Deshpande, D., Holzmann, K., Brenner, D., Andersen, P.M., Petri, S., Thal, D.R., Michaelis, J., Otto, M., Just, S., Ludolph, A.C., Danzer, K.M., Freischmidt, A., Weishaupt, J.H., 2018. Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS. Cell. Mol. Life Sci. https://doi.org/10.1007/s00018-018-2873-1

Herling, C.D., Abedpour, N., Weiss, J., Schmitt, A., Jachimowicz, R.D., Merkel, O., Cartolano, M., Oberbeck, S., Mayer, P., Berg, V., Thomalla, D., Kutsch, N., Stiefelhagen, M., Cramer, P., Wendtner, C.-M., Persigehl, T., Saleh, A., Altmüller, J., Nürnberg, P., Pallasch, C., Achter, V., Lang, U., Eichhorst, B., Castiglione, R., Schäfer, S.C., Büttner, R., Kreuzer, K.-A., Reinhardt, H.C., Hallek, M., Frenzel, L.P., Peifer, M., 2018. Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Nat Commun 9, 727. https://doi.org/10.1038/s41467-018-03170-7

Herr, R., Halbach, S., Heizmann, M., Busch, H., Boerries, M., Brummer, T., 2018. BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines. Oncogene. https://doi.org/10.1038/s41388-017-0063-5

Herviou, L., Kassambara, A., Boireau, S., Robert, N., Requirand, G., Müller-Tidow, C., Vincent, L., Seckinger, A., Goldschmidt, H., Cartron, G., Hose, D., Cavalli, G., Moreaux, J., 2018. PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs. Clin Epigenetics 10, 121. https://doi.org/10.1186/s13148-018-0554-4

Hoffmann, A., Sportelli, V., Ziller, M., Spengler, D., 2018. From the Psychiatrist’s Couch to Induced Pluripotent Stem Cells: Bipolar Disease in a Dish. Int J Mol Sci 19. https://doi.org/10.3390/ijms19030770

Hopewell, J.C., Malik, R., Valdés-Márquez, E., Worrall, B.B., Collins, R., METASTROKE Collaboration of the ISGC, 2018. Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke. Eur. Heart J. 39, 354–359. https://doi.org/10.1093/eurheartj/ehx373

Hopp, L., Loeffler-Wirth, H., Nersisyan, L., Arakelyan, A., Binder, H., 2018. Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome. Front Immunol 9, 1620. https://doi.org/10.3389/fimmu.2018.01620

Howell, K.J., Kraiczy, J., Nayak, K.M., Gasparetto, M., Ross, A., Lee, C., Mak, T.N., Koo, B.-K., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M., 2018. DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology 154, 585–598. https://doi.org/10.1053/j.gastro.2017.10.007

Hughes, T., Sønderby, I.E., Polushina, T., Hansson, L., Holmgren, A., Athanasiu, L., Melbø-Jørgensen, C., Hassani, S., Hoeffding, L.K., Herms, S., Bergen, S.E., Karlsson, R., Song, J., Rietschel, M., Nöthen, M.M., Forstner, A.J., Hoffmann, P., Hultman, C.M., Landén, M., Cichon, S., Werge, T., Andreassen, O.A., Le Hellard, S., Djurovic, S., 2018. Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder. Transl Psychiatry 8, 210. https://doi.org/10.1038/s41398-018-0175-x

International Consortium on Lithium Genetics (ConLi+Gen), Amare, A.T., Schubert, K.O., Hou, L., Clark, S.R., Papiol, S., Heilbronner, U., Degenhardt, F., Tekola-Ayele, F., Hsu, Y.-H., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J.-M., Backlund, L., Bhattacharjee, A.K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J.M., Birner, A., Brichant-Petitjean, C., Cervantes, P., Chen, H.-C., Chillotti, C., Cichon, S., Cruceanu, C., Czerski, P.M., Dalkner, N., Dayer, A., Del Zompo, M., DePaulo, J.R., Étain, B., Falkai, P., Forstner, A.J., Frisen, L., Frye, M.A., Fullerton, J.M., Gard, S., Garnham, J.S., Goes, F.S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hauser, J., Herms, S., Hoffmann, P., Hofmann, A., Jamain, S., Jiménez, E., Kahn, J.-P., Kassem, L., Kuo, P.-H., Kato, T., Kelsoe, J., Kittel-Schneider, S., Kliwicki, S., König, B., Kusumi, I., Laje, G., Landén, M., Lavebratt, C., Leboyer, M., Leckband, S.G., Tortorella, A., Manchia, M., Martinsson, L., McCarthy, M.J., McElroy, S., Colom, F., Mitjans, M., Mondimore, F.M., Monteleone, P., Nievergelt, C.M., Nöthen, M.M., Novák, T., O’Donovan, C., Ozaki, N., Ösby, U., Pfennig, A., Potash, J.B., Reif, A., Reininghaus, E., Rouleau, G.A., Rybakowski, J.K., Schalling, M., Schofield, P.R., Schweizer, B.W., Severino, G., Shilling, P.D., Shimoda, K., Simhandl, C., Slaney, C.M., Squassina, A., Stamm, T., Stopkova, P., Maj, M., Turecki, G., Vieta, E., Volkert, J., Witt, S., Wright, A., Zandi, P.P., Mitchell, P.B., Bauer, M., Alda, M., Rietschel, M., McMahon, F.J., Schulze, T.G., Baune, B.T., 2018. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. JAMA Psychiatry 75, 65–74. https://doi.org/10.1001/jamapsychiatry.2017.3433

International Stem Cell Initiative, 2018. Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. Nat Commun 9, 1925. https://doi.org/10.1038/s41467-018-04011-3

Iuso, A., Alhaddad, B., Weigel, C., Kotzaeridou, U., Mastantuono, E., Schwarzmayr, T., Graf, E., Terrile, C., Prokisch, H., Strom, T.M., Hoffmann, G.F., Meitinger, T., Haack, T.B., 2018. A Homozygous Splice Site Mutation in SLC25A42, Encoding the Mitochondrial Transporter of Coenzyme A, Causes Metabolic Crises and Epileptic Encephalopathy. JIMD Rep. https://doi.org/10.1007/8904_2018_115

Jacob, S.N., Hähnke, D., Nieder, A., 2018. Structuring of Abstract Working Memory Content by Fronto-parietal Synchrony in Primate Cortex. Neuron 99, 588-597.e5. https://doi.org/10.1016/j.neuron.2018.07.025

Jacob, S.N., Nienborg, H., 2018. Monoaminergic Neuromodulation of Sensory Processing. Front Neural Circuits 12, 51. https://doi.org/10.3389/fncir.2018.00051

Jacobs, G., Wolf, A., Krawczak, M., Lieb, W., 2018. Biobanks in the Era of Digital Medicine. Clin. Pharmacol. Ther. 103, 761–762. https://doi.org/10.1002/cpt.968

Jahreis, S., Trump, S., Bauer, M., Bauer, T., Thürmann, L., Feltens, R., Wang, Q., Gu, L., Grützmann, K., Röder, S., Averbeck, M., Weichenhan, D., Plass, C., Sack, U., Borte, M., Dubourg, V., Schüürmann, G., Simon, J.C., von Bergen, M., Hackermüller, J., Eils, R., Lehmann, I., Polte, T., 2018. Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications. J. Allergy Clin. Immunol. 141, 741–753. https://doi.org/10.1016/j.jaci.2017.03.017

Jung, P.P., Zhang, Z., Paczia, N., Jaeger, C., Ignac, T., May, P., Linster, C.L., 2018. Natural variation of chronological aging in theSaccharomyces cerevisiaespecies reveals diet-dependent mechanisms of life span control. NPJ Aging Mech Dis 4, 3. https://doi.org/10.1038/s41514-018-0022-6

Jung, S., Gamez-Diaz, L., Proietti, M., Grimbacher, B., 2018. “Immune TOR-opathies,” a Novel Disease Entity in Clinical Immunology. Front. Immunol. 9, 966. https://doi.org/10.3389/fimmu.2018.00966

Junge, K.M., Leppert, B., Jahreis, S., Wissenbach, D.K., Feltens, R., Grützmann, K., Thürmann, L., Bauer, T., Ishaque, N., Schick, M., Bewerunge-Hudler, M., Röder, S., Bauer, M., Schulz, A., Borte, M., Landgraf, K., Körner, A., Kiess, W., von Bergen, M., Stangl, G.I., Trump, S., Eils, R., Polte, T., Lehmann, I., 2018. MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development. Clin Epigenetics 10, 58. https://doi.org/10.1186/s13148-018-0478-z

Kachroo, P., Szymczak, S., Heinsen, F.-A., Forster, M., Bethune, J., Hemmrich-Stanisak, G., Baker, L., Schrappe, M., Stanulla, M., Franke, A., 2018. NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia. Epigenomics 10, 133–147. https://doi.org/10.2217/epi-2017-0080

Kalman, J.L., Papiol, S., Forstner, A.J., Heilbronner, U., Degenhardt, F., Strohmaier, J., Adli, M., Adorjan, K., Akula, N., Alda, M., Anderson-Schmidt, H., Andlauer, T.F., Anghelescu, I.-G., Ardau, R., Arias, B., Arolt, V., Aubry, J.-M., Backlund, L., Bartholdi, K., Bauer, M., Baune, B.T., Becker, T., Bellivier, F., Benabarre, A., Bengesser, S., Bhattacharjee, A.K., Biernacka, J.M., Birner, A., Brichant-Petitjean, C., Budde, M., Cervantes, P., Chillotti, C., Cichon, S., Clark, S.R., Colom, F., Comes, A.L., Cruceanu, C., Czerski, P.M., Dannlowski, U., Dayer, A., Del Zompo, M., DePaulo, J.R., Dietrich, D.E., Étain, B., Ethofer, T., Falkai, P., Fallgatter, A., Figge, C., Flatau, L., Folkerts, H., Frisen, L., Frye, M.A., Fullerton, J.M., Gade, K., Gard, S., Garnham, J.S., Goes, F.S., Grigoroiu-Serbanescu, M., Gryaznova, A., Hake, M., Hauser, J., Herms, S., Hoffmann, P., Hou, L., Jäger, M., Jamain, S., Jiménez, E., Juckel, G., Kahn, J.-P., Kassem, L., Kelsoe, J., Kittel-Schneider, S., Kliwicki, S., Klohn-Sagatholislam, F., Koller, M., König, B., Konrad, C., Lackner, N., Laje, G., Landén, M., Lang, F.U., Lavebratt, C., Leboyer, M., Leckband, S.G., Maj, M., Manchia, M., Martinsson, L., McCarthy, M.J., McElroy, S.L., McMahon, F.J., Mitchell, P.B., Mitjans, M., Mondimore, F.M., Monteleone, P., Nieratschker, V., Nievergelt, C.M., Novák, T., Ösby, U., Pfennig, A., Potash, J.B., Reich-Erkelenz, D., Reif, A., Reimer, J., Reininghaus, E., Reitt, M., Ripke, S., Rouleau, G.A., Rybakowski, J.K., Schalling, M., Scherk, H., Schmauß, M., Schofield, P.R., Schubert, K.O., Schulte, E.C., Schulz, S., Senner, F., Severino, G., Shekhtman, T., Shilling, P.D., Simhandl, C., Slaney, C.M., Spitzer, C., Squassina, A., Stamm, T., Stegmaier, S., Stierl, S., Stopkova, P., Thiel, A., Tighe, S.K., Tortorella, A., Turecki, G., Vieta, E., Veeh, J., von Hagen, M., Wigand, M.E., Wiltfang, J., Witt, S., Wright, A., Zandi, P.P., Zimmermann, J., Nöthen, M., Rietschel, M., Schulze, T.G., 2018. Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study. Bipolar Disord. https://doi.org/10.1111/bdi.12659

Kamp, D., Engelke, C., Wobrock, T., Wölwer, W., Winterer, G., Schmidt-Kraepelin, C., Gaebel, W., Langguth, B., Landgrebe, M., Eichhammer, P., Frank, E., Hajak, G., Ohmann, C., Verde, P.E., Rietschel, M., Raees, A., Honer, W.G., Malchow, B., Schneider-Axmann, T., Falkai, P., Hasan, A., Cordes, J., 2018. Left prefrontal high-frequency rTMS may improve movement disorder in schizophrenia patients with predominant negative symptoms - A secondary analysis of a sham-controlled, randomized multicenter trial. Schizophr. Res. https://doi.org/10.1016/j.schres.2018.09.017

Keller, S., Zwingenberger, G., Ebert, K., Hasenauer, J., Wasmuth, J., Maier, D., Haffner, I., Schierle, K., Weirich, G., Luber, B., 2018. Effects of trastuzumab and afatinib on kinase activity in gastric cancer cell lines. Mol Oncol 12, 441–462. https://doi.org/10.1002/1878-0261.12170

Keßler, M., Kieltsch, A., Kayvanpour, E., Katus, H.A., Schoser, B., Schessl, J., Just, S., Rottbauer, W., 2018. A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations. Neuromuscul. Disord. 28, 521–531. https://doi.org/10.1016/j.nmd.2018.03.001

Khayal, L.A., Grünhagen, J., Provazník, I., Mundlos, S., Kornak, U., Robinson, P.N., Ott, C.-E., 2018. Transcriptional profiling of murine osteoblast differentiation based on RNA-seq expression analyses. Bone 113, 29–40. https://doi.org/10.1016/j.bone.2018.04.006

Klett, H., Balavarca, Y., Toth, R., Gigic, B., Habermann, N., Scherer, D., Schrotz-King, P., Ulrich, A., Schirmacher, P., Herpel, E., Brenner, H., Ulrich, C.M., Michels, K.B., Busch, H., Boerries, M., 2018a. Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles. Epigenetics 13, 386–397. https://doi.org/10.1080/15592294.2018.1460034

Klett, H., Fuellgraf, H., Levit-Zerdoun, E., Hussung, S., Kowar, S., Küsters, S., Bronsert, P., Werner, M., Wittel, U., Fritsch, R., Busch, H., Boerries, M., 2018b. Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet 9, 108. https://doi.org/10.3389/fgene.2018.00108

Kluth, M., Scherzai, S., Büschek, F., Fraune, C., Möller, K., Höflmayer, D., Minner, S., Göbel, C., Möller-Koop, C., Hinsch, A., Neubauer, E., Tsourlakis, M.C., Sauter, G., Heinzer, H., Graefen, M., Wilczak, W., Luebke, A.M., Burandt, E., Steurer, S., Schlomm, T., Simon, R., 2018. 13q deletion is linked to an adverse phenotype and poor prognosis in prostate cancer. Genes Chromosomes Cancer 57, 504–512. https://doi.org/10.1002/gcc.22645

Knittel, G., Rehkämper, T., Nieper, P., Schmitt, A., Flümann, R., Reinhardt, H.C., 2018. DNA damage pathways and B-cell lymphomagenesis. Curr. Opin. Hematol. 25, 315–322. https://doi.org/10.1097/MOH.0000000000000433

Knüppel, R., Christensen, R.H., Gray, F.C., Esser, D., Strauß, D., Medenbach, J., Siebers, B., MacNeill, S.A., LaRonde, N., Ferreira-Cerca, S., 2018. Insights into the evolutionary conserved regulation of Rio ATPase activity. Nucleic Acids Res. 46, 1441–1456. https://doi.org/10.1093/nar/gkx1236

Koszinowski, S., La Padula, V., Edlich, F., Krieglstein, K., Busch, H., Boerries, M., 2018. Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development. Front Physiol 9, 797. https://doi.org/10.3389/fphys.2018.00797

Kramer, F., Just, S., Zeller, T., 2018. New perspectives: systems medicine in cardiovascular disease. BMC Syst Biol 12, 57. https://doi.org/10.1186/s12918-018-0579-5

Kraus, J.M., Lausser, L., Kuhn, P., Jobst, F., Bock, M., Halanke, C., Hummel, M., Heuschmann, P., Kestler, H.A., 2018. Big data and precision medicine: challenges and strategies with healthcare data. Int J Data Sci Anal 1–9. https://doi.org/10.1007/s41060-018-0095-0

Krause, J., Löser, A., Lemoine, M.D., Christ, T., Scherschel, K., Meyer, C., Blankenberg, S., Zeller, T., Eschenhagen, T., Stenzig, J., 2018. Rat atrial engineered heart tissue: a new in vitro model to study atrial biology. Basic Res. Cardiol. 113, 41. https://doi.org/10.1007/s00395-018-0701-2

Krug, A., Dietsche, B., Zöllner, R., Yüksel, D., Nöthen, M.M., Forstner, A.J., Rietschel, M., Dannlowski, U., Baune, B.T., Maier, R., Witt, S.H., Kircher, T., 2018. Polygenic risk for schizophrenia affects working memory and its neural correlates in healthy subjects. Schizophr. Res. https://doi.org/10.1016/j.schres.2018.01.013

Kustermann, M., Manta, L., Paone, C., Kustermann, J., Lausser, L., Wiesner, C., Eichinger, L., Clemen, C.S., Schröder, R., Kestler, H.A., Sandri, M., Rottbauer, W., Just, S., 2018. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy. https://doi.org/10.1080/15548627.2018.1491491

Lausser, L., Szekely, R., Kessler, V., Schwenker, F., Kestler, H.A., 2018. Selecting Features from Foreign Classes, in: Pancioni, L., Schwenker, F., Trentin, E. (Eds.), Artificial Neural Networks in Pattern Recognition, Lecture Notes in Computer Science. Springer International Publishing, pp. 66–77.

Lehners, N., Becker, N., Benner, A., Pritsch, M., Löpprich, M., Mai, E.K., Hillengass, J., Goldschmidt, H., Raab, M.-S., 2018. Analysis of long-term survival in multiple myeloma after first-line autologous stem cell transplantation: impact of clinical risk factors and sustained response. Cancer Med 7, 307–316. https://doi.org/10.1002/cam4.1283

Lenz, D., McClean, P., Kansu, A., Bonnen, P.E., Ranucci, G., Thiel, C., Straub, B.K., Harting, I., Alhaddad, B., Dimitrov, B., Kotzaeridou, U., Wenning, D., Iorio, R., Himes, R.W., Kuloğlu, Z., Blakely, E.L., Taylor, R.W., Meitinger, T., Kölker, S., Prokisch, H., Hoffmann, G.F., Haack, T.B., Staufner, C., 2018. SCYL1 variants cause a syndrome with low γ-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). Genet. Med. https://doi.org/10.1038/gim.2017.260

Leseva, M.N., Grand, R.J., Klett, H., Boerries, M., Busch, H., Binder, A.M., Michels, K.B., 2018. Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals. Sci Rep 8, 5649. https://doi.org/10.1038/s41598-018-23957-4

Leuchs, L., Schneider, M., Spoormaker, V.I., 2018. Measuring the conditioned response: A comparison of pupillometry, skin conductance, and startle electromyography. Psychophysiology e13283. https://doi.org/10.1111/psyp.13283

Luke, B., 2018. Telomere regulation. Differentiation 102, 27–29. https://doi.org/10.1016/j.diff.2018.06.002

Macare, C., Ducci, F., Zhang, Y., Ruggeri, B., Jia, T., Kaakinen, M., Kalsi, G., Charoen, P., Casoni, F., Peters, J., Bromberg, U., Hill, M., Buxton, J., Blakemore, A., Veijola, J., Büchel, C., Banaschewski, T., Bokde, A.L.W., Conrod, P., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P.A., Heinz, A., Ittermann, B., Lathrop, M., Martinot, J.-L., Paus, T., Desrivières, S., Munafò, M., Järvelin, M.-R., Schumann, G., 2018. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. European Neuropsychopharmacology. https://doi.org/10.1016/j.euroneuro.2018.07.101

Macheleidt, I.F., Dalvi, P.S., Lim, S.-Y., Meemboor, S., Meder, L., Käsgen, O., Müller, M., Kleemann, K., Wang, L., Nürnberg, P., Rüsseler, V., Schäfer, S.C., Mahabir, E., Büttner, R., Odenthal, M., 2018. Preclinical studies reveal that LSD1 inhibition results in tumor growth arrest in lung adenocarcinoma independently of driver mutations. Mol Oncol. https://doi.org/10.1002/1878-0261.12382

Magnussen, C., Ojeda, F.M., Wild, P.S., Sörensen, N., Rostock, T., Hoffmann, B.A., Prochaska, J., Lackner, K.J., Beutel, M.E., Blettner, M., Pfeiffer, N., Rzayeva, N., Sinning, C.R., Blankenberg, S., Münzel, T., Zeller, T., Schnabel, R.B., 2018. Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). Am. J. Cardiol. 122, 76–82. https://doi.org/10.1016/j.amjcard.2018.03.028

Mahmoudpour, S.H., Bandapalli, O.R., da Silva Filho, M.I., Campo, C., Hemminki, K., Goldschmidt, H., Merz, M., Försti, A., 2018. Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients. BMC Cancer 18, 820. https://doi.org/10.1186/s12885-018-4728-4

Mai, E.K., Haas, E.-M., Lücke, S., Löpprich, M., Kunz, C., Pritsch, M., Knaup-Gregori, P., Raab, M.S., Schlenzka, J., Bertsch, U., Hillengass, J., Goldschmidt, H., 2018. A systematic classification of death causes in multiple myeloma. Blood Cancer J 8, 30. https://doi.org/10.1038/s41408-018-0068-5

Maier, L.J., Kallenberger, S.M., Jechow, K., Waschow, M., Eils, R., Conrad, C., 2018. Unraveling mitotic protein networks by 3D multiplexed epitope drug screening. Mol. Syst. Biol. 14, e8238.

Malik, R., Dichgans, M., 2018. Challenges and opportunities in stroke genetics. Cardiovasc. Res. 114, 1226–1240. https://doi.org/10.1093/cvr/cvy068

Marin-Sanguino, A., Vera, J., Alves, R., 2018. Editorial: Foundations of Theoretical Approaches in Systems Biology. Front. Genet. 9, 290. https://doi.org/10.3389/fgene.2018.00290

Meder, L., König, K., Dietlein, F., Macheleidt, I., Florin, A., Ercanoglu, M.S., Rommerscheidt-Fuss, U., Koker, M., Schön, G., Odenthal, M., Klein, F., Büttner, R., Schulte, J.H., Heukamp, L.C., Ullrich, R.T., 2018a. LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model. Oncogene 37, 2746–2756. https://doi.org/10.1038/s41388-018-0158-7

Meder, L., Schuldt, P., Thelen, M., Schmitt, A., Dietlein, F., Klein, S., Borchmann, S., Wennhold, K., Vlasic, I., Oberbeck, S., Riedel, R., Florin, A., Golfmann, K., Schlößer, H.A., Odenthal, M., Buettner, R., Wolf, J., Hallek, M., Herling, M., von Bergwelt-Baildon, M., Reinhardt, H.C., Ullrich, R.T., 2018b. Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer. Cancer Res. 78, 4270–4281. https://doi.org/10.1158/0008-5472.CAN-17-2176

Merz, M., Hielscher, T., Hoffmann, K., Seckinger, A., Hose, D., Raab, M.S., Hillengass, J., Jauch, A., Goldschmidt, H., 2018a. Cytogenetic abnormalities in monoclonal gammopathy of undetermined significance. Leukemia. https://doi.org/10.1038/s41375-018-0202-1

Merz, M., Jauch, A., Hielscher, T., Bochtler, T., Schönland, S.O., Seckinger, A., Hose, D., Bertsch, U., Neben, K., Raab, M.S., Hillengass, J., Salwender, H., Blau, I.W., Lindemann, H.-W., Schmidt-Wolf, I.G.H., Scheid, C., Haenel, M., Weisel, K.C., Goldschmidt, H., 2018b. Prognostic significance of cytogenetic heterogeneity in patients with newly diagnosed multiple myeloma. Blood Adv 2, 1–9. https://doi.org/10.1182/bloodadvances.2017013334

Messer, M., Albert, S., Schneider, G., 2018. The multiple filter test for change point detection in time series. Metrika 81, 589–607. https://doi.org/10.1007/s00184-018-0672-1

Meyer-Hermann, M., Binder, S.C., Mesin, L., Victora, G.D., 2018. Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers. Front. Immunol. 9. https://doi.org/10.3389/fimmu.2018.02020

Michelini, F., Jalihal, A.P., Francia, S., Meers, C., Neeb, Z.T., Rossiello, F., Gioia, U., Aguado, J., Jones-Weinert, C., Luke, B., Biamonti, G., Nowacki, M., Storici, F., Carninci, P., Walter, N.G., Fagagna, F. d’Adda di, 2018. From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond. Chem. Rev. 118, 4365–4403. https://doi.org/10.1021/acs.chemrev.7b00487

Misino, S., Bonetti, D., Luke-Glaser, S., Luke, B., 2018. Increased TERRA levels and RNase H sensitivity are conserved hallmarks of post-senescent survivors in budding yeast. Differentiation 100, 37–45. https://doi.org/10.1016/j.diff.2018.02.002

Mohr, C., Friedrich, A., Wojnar, D., Kenar, E., Polatkan, A.C., Codrea, M.C., Czemmel, S., Kohlbacher, O., Nahnsen, S., 2018. qPortal: A platform for data-driven biomedical research. PLoS ONE 13, e0191603. https://doi.org/10.1371/journal.pone.0191603

Mohr, M., Hose, D., Seckinger, A., Marciniak-Czochra, A., 2018. Quantification of plasma cell dynamics using mathematical modelling. R Soc Open Sci 5, 170759. https://doi.org/10.1098/rsos.170759

Moschall, R., Strauss, D., García-Beyaert, M., Gebauer, F., Medenbach, J., 2018. Drosophila Sister-of-Sex-lethal is a repressor of translation. RNA 24, 149–158. https://doi.org/10.1261/rna.063776.117

Muckenhuber, A., Berger, A.K., Schlitter, A.M., Steiger, K., Konukiewitz, B., Trumpp, A., Eils, R., Werner, J., Friess, H., Esposito, I., Klöppel, G., Ceyhan, G.O., Jesinghaus, M., Denkert, C., Bahra, M., Stenzinger, A., Sprick, M.R., Jäger, D., Springfeld, C., Weichert, W., 2018. Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response. Clin. Cancer Res. 24, 351–359. https://doi.org/10.1158/1078-0432.CCR-17-2180

Mühleisen, T.W., Reinbold, C.S., Forstner, A.J., Abramova, L.I., Alda, M., Babadjanova, G., Bauer, M., Brennan, P., Chuchalin, A., Cruceanu, C., Czerski, P.M., Degenhardt, F., Fischer, S.B., Fullerton, J.M., Gordon, S.D., Grigoroiu-Serbanescu, M., Grof, P., Hauser, J., Hautzinger, M., Herms, S., Hoffmann, P., Kammerer-Ciernioch, J., Khusnutdinova, E., Kogevinas, M., Krasnov, V., Lacour, A., Laprise, C., Leber, M., Lissowska, J., Lucae, S., Maaser, A., Maier, W., Martin, N.G., Mattheisen, M., Mayoral, F., McKay, J.D., Medland, S.E., Mitchell, P.B., Moebus, S., Montgomery, G.W., Müller-Myhsok, B., Oruc, L., Pantelejeva, G., Pfennig, A., Pojskic, L., Polonikov, A., Reif, A., Rivas, F., Rouleau, G.A., Schenk, L.M., Schofield, P.R., Schwarz, M., Streit, F., Strohmaier, J., Szeszenia-Dabrowska, N., Tiganov, A.S., Treutlein, J., Turecki, G., Vedder, H., Witt, S.H., Schulze, T.G., Rietschel, M., Nöthen, M.M., Cichon, S., 2018. Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder 20–25.

Müller, I., Kulms, D., 2018. A 3D Organotypic Melanoma Spheroid Skin Model. J Vis Exp. https://doi.org/10.3791/57500

Neupane, B., Zhou, Q., Gawaz, M., Gramlich, M., 2018. Personalized medicine in inflammatory cardiomyopathy. Pers. Med. 15, 127–136. https://doi.org/10.2217/pme-2017-0074

Nikolaus, S., Waetzig, G.H., Butzin, S., Ziolkiewicz, M., Al-Massad, N., Thieme, F., Lövgren, U., Rasmussen, B.B., Reinheimer, T.M., Seegert, D., Rosenstiel, P., Szymczak, S., Schreiber, S., 2018. Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases. Int J Colorectal Dis. https://doi.org/10.1007/s00384-018-3069-8

Nürnberg, E., Horschitz, S., Schloss, P., Meyer-Lindenberg, A., 2018. Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells. J. Steroid Biochem. Mol. Biol. https://doi.org/10.1016/j.jsbmb.2018.04.017

Obst, E., Schad, D.J., Huys, Q.J., Sebold, M., Nebe, S., Sommer, C., Smolka, M.N., Zimmermann, U.S., 2018. Drunk decisions: Alcohol shifts choice from habitual towards goal-directed control in adolescent intermediate-risk drinkers. J. Psychopharmacol. (Oxford) 32, 855–866. https://doi.org/10.1177/0269881118772454

Oliver, A.L.-S., Baumgart, S., Bremser, W., Flemig, S., Wittke, D., Gruetzkau, A., Luch, A., Haase, A., Jakubowski, N., 2018. Quantification of silver nanoparticles taken up by single cells using inductively coupled plasma mass spectrometry in the single cell measurement mode. J. Anal. At. Spectrom. 33, 1256–1263. https://doi.org/10.1039/c7ja00395a

Paone, C., Diofano, F., Park, D.-D., Rottbauer, W., Just, S., 2018a. Genetics of Cardiovascular Disease: Fishing for Causality. Front. Cardiovasc. Med. 5. https://doi.org/10.3389/fcvm.2018.00060

Paone, C., Rudeck, S., Etard, C., Strähle, U., Rottbauer, W., Just, S., 2018b. Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response. Biochem. Biophys. Res. Commun. 496, 339–345. https://doi.org/10.1016/j.bbrc.2018.01.060

Papanastasiou, E., Mouchlianitis, E., Joyce, D.W., McGuire, P., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Spechler, P., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Millenet, S., Fröhner, J.H., Smolka, M.N., Walter, H., Whelan, R., Schumann, G., Shergill, S., IMAGEN Consortium, 2018. Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2018.1973

Papiol, S., Schulze, T.G., Alda, M., 2018. Genetics of Lithium Response in Bipolar Disorder. Pharmacopsychiatry 51, 206–211. https://doi.org/10.1055/a-0590-4992

Pastor, V.B., Sahoo, S.S., Boklan, J., Schwabe, G.C., Saribeyoglu, E., Strahm, B., Lebrecht, D., Voss, M., Bryceson, Y.T., Erlacher, M., Ehninger, G., Niewisch, M., Schlegelberger, B., Baumann, I., Achermann, J.C., Shimamura, A., Hochrein, J., Tedgård, U., Nilsson, L., Hasle, H., Boerries, M., Busch, H., Niemeyer, C.M., Wlodarski, M.W., 2018. ConstitutionalSAMD9Lmutations cause familial myelodysplastic syndrome and transient monosomy 7. Haematologica 103, 427–437. https://doi.org/10.3324/haematol.2017.180778

Patel, Y., Shin, J., Gowland, P.A., Pausova, Z., Paus, T., IMAGEN consortium, 2018. Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor? Cereb. Cortex. https://doi.org/10.1093/cercor/bhy204

Paul, U., Richter, J., Stuhlmann-Laiesz, C., Kreuz, M., Nagel, I., Horn, H., Staiger, A.M., Aukema, S.M., Hummel, M., Ott, G., Spang, R., Rosenwald, A., Feller, A.C., Cogliatti, S., Stein, H., Hansmann, M.-L., Moller, P., Szczepanowski, M., Burkhardt, B., Pfreundschuh, M., Schmitz, N., Loeffler, M., Trümper, L., Siebert, R., Klapper, W., 2018. Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC. Leuk. Lymphoma 59, 1213–1221. https://doi.org/10.1080/10428194.2017.1365851

Perera-Bel, J., Hutter, B., Heining, C., Bleckmann, A., Fröhlich, M., Fröhling, S., Glimm, H., Brors, B., Beißbarth, T., 2018. From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards. Genome Med 10, 18. https://doi.org/10.1186/s13073-018-0529-2

Piel, J.H., Lett, T.A., Wackerhagen, C., Plichta, M.M., Mohnke, S., Grimm, O., Romanczuk-Seiferth, N., Degenhardt, F., Tost, H., Witt, S., Nöthen, M., Rietschel, M., Heinz, A., Meyer-Lindenberg, A., Walter, H., Erk, S., 2018. The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. Eur Neuropsychopharmacol. https://doi.org/10.1016/j.euroneuro.2017.12.014

Plass, M., Solana, J., Wolf, F.A., Ayoub, S., Misios, A., Glažar, P., Obermayer, B., Theis, F.J., Kocks, C., Rajewsky, N., 2018. Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics. Science 360. https://doi.org/10.1126/science.aaq1723

Plenker, D., Bertrand, M., de Langen, A.J., Riedel, R., Lorenz, C., Scheel, A.H., Müller, J., Brägelmann, J., Daßler-Plenker, J., Kobe, C., Persigehl, T., Kluge, A., Wurdinger, T., Schellen, P., Hartmann, G., Zacherle, T., Menon, R., Thunnissen, E., Büttner, R., Griesinger, F., Wolf, J., Heukamp, L., Sos, M.L., Heuckmann, J.M., 2018. Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients. Clin. Cancer Res. 24, 1337–1343. https://doi.org/10.1158/1078-0432.CCR-17-3001

Pott, A., Bock, S., Berger, I.M., Frese, K., Dahme, T., Keßler, M., Rinné, S., Decher, N., Just, S., Rottbauer, W., 2018. Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish. J. Mol. Cell. Cardiol. 120, 42–52. https://doi.org/10.1016/j.yjmcc.2018.05.005

Prestipino, A., Emhardt, A.J., Aumann, K., O’Sullivan, D., Gorantla, S.P., Duquesne, S., Melchinger, W., Braun, L., Vuckovic, S., Boerries, M., Busch, H., Halbach, S., Pennisi, S., Poggio, T., Apostolova, P., Veratti, P., Hettich, M., Niedermann, G., Bartholomä, M., Shoumariyeh, K., Jutzi, J.S., Wehrle, J., Dierks, C., Becker, H., Schmitt-Graeff, A., Follo, M., Pfeifer, D., Rohr, J., Fuchs, S., Ehl, S., Hartl, F.A., Minguet, S., Miething, C., Heidel, F.H., Kröger, N., Triviai, I., Brummer, T., Finke, J., Illert, A.L., Ruggiero, E., Bonini, C., Duyster, J., Pahl, H.L., Lane, S.W., Hill, G.R., Blazar, B.R., von Bubnoff, N., Pearce, E.L., Zeiser, R., 2018. Oncogenic JAK2V617Fcauses PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Sci Transl Med 10. https://doi.org/10.1126/scitranslmed.aam7729

PubMed entry, n.d.

Puusepp, S., Kovacs-Nagy, R., Alhaddad, B., Braunisch, M., Hoffmann, G.F., Kotzaeridou, U., Lichvarova, L., Liiv, M., Makowski, C., Mandel, M., Meitinger, T., Pajusalu, S., Rodenburg, R.J., Safiulina, D., Strom, T.M., Talvik, I., Vaarmann, A., Wilson, C., Kaasik, A., Haack, T.B., Õunap, K., 2018. Compound heterozygous SPATA5 variants in four families and functional studies of SPATA5 deficiency. Eur. J. Hum. Genet. 26, 407–419. https://doi.org/10.1038/s41431-017-0001-6

Reichert, M., Bakir, B., Moreira, L., Pitarresi, J.R., Feldmann, K., Simon, L., Suzuki, K., Maddipati, R., Rhim, A.D., Schlitter, A.M., Kriegsmann, M., Weichert, W., Wirth, M., Schuck, K., Schneider, G., Saur, D., Reynolds, A.B., Klein-Szanto, A.J., Pehlivanoglu, B., Memis, B., Adsay, N.V., Rustgi, A.K., 2018. Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev. Cell 45, 696-711.e8. https://doi.org/10.1016/j.devcel.2018.05.025

Reinke, S., Richter, J., Fend, F., Feller, A., Hansmann, M.-L., Hüttl, K., Oschlies, I., Ott, G., Möller, P., Rosenwald, A., Stein, H., Altenbuchinger, M., Spang, R., Klapper, W., 2018. Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma-a feasibility study using full slide staining. Virchows Arch. 473, 341–349. https://doi.org/10.1007/s00428-018-2367-4

Rinschen, M.M., Gödel, M., Grahammer, F., Zschiedrich, S., Helmstädter, M., Kretz, O., Zarei, M., Braun, D.A., Dittrich, S., Pahmeyer, C., Schroder, P., Teetzen, C., Gee, H., Daouk, G., Pohl, M., Kuhn, E., Schermer, B., Küttner, V., Boerries, M., Busch, H., Schiffer, M., Bergmann, C., Krüger, M., Hildebrandt, F., Dengjel, J., Benzing, T., Huber, T.B., 2018. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep 23, 2495–2508. https://doi.org/10.1016/j.celrep.2018.04.059

Roeben, B., Schüle, R., Ruf, S., Bender, B., Alhaddad, B., Benkert, T., Meitinger, T., Reich, S., Böhringer, J., Langhans, C.-D., Vaz, F.M., Wortmann, S.B., Marquardt, T., Haack, T.B., Krägeloh-Mann, I., Schöls, L., Synofzik, M., 2018. SERAC1 deficiency causes complicated HSP: evidence from a novel splice mutation in a large family. J. Med. Genet. 55, 39–47. https://doi.org/10.1136/jmedgenet-2017-104622

Rotermund, C., Machetanz, G., Fitzgerald, J.C., 2018. The Therapeutic Potential of Metformin in Neurodegenerative Diseases. Front. Endocrinol. 9. https://doi.org/10.3389/fendo.2018.00400

Ruiz-Moreno, Juan Sebastian, Hamann, L., Jin, L., Sander, L.E., Puzianowska-Kuznicka, M., Cambier, J., Witzenrath, M., Schumann, R.R., Suttorp, N., Opitz, B., 2018. The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infect. Immun. 86. https://doi.org/10.1128/IAI.00849-17

Ruiz-Moreno, Juan S., Hamann, L., Shah, J.A., Verbon, A., Mockenhaupt, F.P., Puzianowska-Kuznicka, M., Naujoks, J., Sander, L.E., Witzenrath, M., Cambier, J.C., Suttorp, N., Schumann, R.R., Jin, L., Hawn, T.R., Opitz, B., CAPNETZ Study Group, 2018. The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans. PLoS Pathog. 14, e1006829. https://doi.org/10.1371/journal.ppat.1006829

Sander, L.E., Garaude, J., 2018. The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses. Mitochondrion 41, 28–36. https://doi.org/10.1016/j.mito.2017.10.008

Santos, G., Lai, X., Eberhardt, M., Vera, J., 2018. Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling. Front. Cell. Infect. Microbiol. 8. https://doi.org/10.3389/fcimb.2018.00159

Saporito-Magriñá, C.M., Sebio, R.N.M., Andrieux, G., Kook, L., Orrego, M.T., Tuttolomondo, M.V., Desimone, M., Boerries, M., Borner, C., Repetto, M.G., 2018. Copper-induced cell death and the protective role of glutathione: implication of impaired protein folding rather than oxidative stress. Metallomics. https://doi.org/10.1039/C8MT00182K

Schäffner, I., Minakaki, G., Khan, M.A., Balta, E.-A., Schlötzer-Schrehardt, U., Schwarz, T.J., Beckervordersandforth, R., Winner, B., Webb, A.E., DePinho, R.A., Paik, J., Wurst, W., Klucken, J., Lie, D.C., 2018. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron 99, 1188-1203.e6. https://doi.org/10.1016/j.neuron.2018.08.017

Schilling, C., Gappa, L., Schredl, M., Streit, F., Treutlein, J., Frank, J., Deuschle, M., Meyer-Lindenberg, A., Rietschel, M., Witt, S.H., 2018. Fast sleep spindle density is associated with rs4680 (Val108/158Met) genotype of catechol-O-methyltransferase (COMT). Sleep 41. https://doi.org/10.1093/sleep/zsy007

Schirm, S., Engel, C., Loibl, S., Loeffler, M., Scholz, M., 2018. Model-based optimization of G-CSF treatment during cytotoxic chemotherapy. J. Cancer Res. Clin. Oncol. 144, 343–358. https://doi.org/10.1007/s00432-017-2540-1

Schlereth, K., Weichenhan, D., Bauer, T., Heumann, T., Giannakouri, E., Lipka, D., Jaeger, S., Schlesner, M., Aloy, P., Eils, R., Plass, C., Augustin, H.G., 2018. The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife 7. https://doi.org/10.7554/eLife.34423

Schmidt, N., Haydn, T., Schneider, I., Busch, H., Boerries, M., Fulda, S., 2018. Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling. Cancer Lett. https://doi.org/10.1016/j.canlet.2018.01.082

Schmitt, A., Feldmann, G., Zander, T., Reinhardt, H.C., 2018. Targeting Defects in the Cellular DNA Damage Response for the Treatment of Pancreatic Ductal Adenocarcinoma. Oncol Res Treat 41, 619–625. https://doi.org/10.1159/000493401

Schnabel, R.B., Pecen, L., Rzayeva, N., Lucerna, M., Purmah, Y., Ojeda, F.M., De Caterina, R., Kirchhof, P., 2018. Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe. J Am Heart Assoc 7. https://doi.org/10.1161/JAHA.117.007559

Schofer, N., Ludwig, S., Rübsamen, N., Schnabel, R., Lackner, K.J., Ruprecht, H.J., Bickel, C., Landmesser, U., Blankenberg, S., Zeller, T., 2018. Prognostic impact of Interleukin-1 receptor antagonist in patients with documented coronary artery disease. Int. J. Cardiol. 257, 24–29. https://doi.org/10.1016/j.ijcard.2018.01.055

Schubert, D., Klein, M.-C., Hassdenteufel, S., Caballero-Oteyza, A., Yang, L., Proietti, M., Bulashevska, A., Kemming, J., Kühn, J., Winzer, S., Rusch, S., Fliegauf, M., Schäffer, A.A., Pfeffer, S., Geiger, R., Cavalié, A., Cao, H., Yang, F., Li, Y., Rizzi, M., Eibel, H., Kobbe, R., Marks, A.L., Peppers, B.P., Hostoffer, R.W., Puck, J.M., Zimmermann, R., Grimbacher, B., 2018. Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1). J. Allergy Clin. Immunol. 141, 1427–1438. https://doi.org/10.1016/j.jaci.2017.06.042

Schulte-Wrede, U., Sörensen, T., Grün, J.R., Häupl, T., Hirseland, H., Steinbrich-Zöllner, M., Wu, P., Radbruch, A., Poddubnyy, D., Sieper, J., Syrbe, U., Grützkau, A., 2018. An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus. Arthritis Res. Ther. 20, 191. https://doi.org/10.1186/s13075-018-1692-y

Schultze, J.L., SYSCID consortium, Rosenstiel, P., 2018. Systems Medicine in Chronic Inflammatory Diseases. Immunity 48, 608–613. https://doi.org/10.1016/j.immuni.2018.03.022

Schumann, B., Reppe, K., Kaplonek, P., Wahlbrink, A., Anish, C., Witzenrath, M., Pereira, C.L., Seeberger, P.H., 2018. Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1. ACS Cent Sci 4, 357–361. https://doi.org/10.1021/acscentsci.7b00504

Schunkert, H., 2018. Genetics of CVD in 2017: Expanding the spectrum of CVD genetics. Nat Rev Cardiol 15, 77–78. https://doi.org/10.1038/nrcardio.2017.209

Schunkert, H., Samani, N.J., 2018. Into the great wide open: 10 years of genome-wide association studies. Cardiovasc. Res. 114, 1189–1191. https://doi.org/10.1093/cvr/cvy100

Schunkert, H., von Scheidt, M., Kessler, T., Stiller, B., Zeng, L., Vilne, B., 2018. Genetics of coronary artery disease in the light of genome-wide association studies. Clin Res Cardiol 107, 2–9. https://doi.org/10.1007/s00392-018-1324-1

Schwab, J.D., Kestler, H.A., 2018. Automatic Screening for Perturbations in Boolean Networks. Front Physiol 9, 431. https://doi.org/10.3389/fphys.2018.00431

Seckinger, A., Bähr-Ivacevic, T., Benes, V., Hose, D., 2018a. RNA-Sequencing from Low-Input Material in Multiple Myeloma for Application in Clinical Routine, in: Multiple Myeloma, Methods in Molecular Biology. Humana Press, New York, NY, pp. 97–115. https://doi.org/10.1007/978-1-4939-7865-6_7

Seckinger, A., Hillengass, J., Emde, M., Beck, S., Kimmich, C., Dittrich, T., Hundemer, M., Jauch, A., Hegenbart, U., Raab, M.-S., Ho, A.D., Schönland, S., Hose, D., 2018b. CD38 as Immunotherapeutic Target in Light Chain Amyloidosis and Multiple Myeloma-Association With Molecular Entities, Risk, Survival, and Mechanisms of Upfront Resistance. Front Immunol 9, 1676. https://doi.org/10.3389/fimmu.2018.01676

Seehawer, M., Heinzmann, F., D’Artista, L., Harbig, J., Roux, P.-F., Hoenicke, L., Dang, H., Klotz, S., Robinson, L., Doré, G., Rozenblum, N., Kang, T.-W., Chawla, R., Buch, T., Vucur, M., Roth, M., Zuber, J., Luedde, T., Sipos, B., Longerich, T., Heikenwälder, M., Wang, X.W., Bischof, O., Zender, L., 2018. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature. https://doi.org/10.1038/s41586-018-0519-y

Segert, J., Schneider, I., Berger, I.M., Rottbauer, W., Just, S., 2018. Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish. Progress in Biophysics and Molecular Biology. https://doi.org/10.1016/j.pbiomolbio.2018.07.010

Seo, S., Beck, A., Matthis, C., Genauck, A., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Flor, H., Frouin, V., Garavan, H., Gowland, P., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Hohmann, S., Fröhner, J.H., Smolka, M.N., Walter, H., Whelan, R., Desrivières, S., Heinz, A., Schumann, G., Obermayer, K., 2018. Risk profiles for heavy drinking in adolescence: differential effects of gender. Addict Biol. https://doi.org/10.1111/adb.12636

Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L.J., Eckert, D., Hebisch, M., Fischer, J., Kesavan, J., Weykopf, B., Schneider, L., Holtkamp, D., Beck, H., Till, A., Wüllner, U., Ziller, M.J., Wagner, W., Peitz, M., Brüstle, O., 2018. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nat Commun 9, 4047. https://doi.org/10.1038/s41467-018-06398-5

Siegemund, M., Schneider, F., Hutt, M., Seifert, O., Müller, I., Kulms, D., Pfizenmaier, K., Kontermann, R.E., 2018. IgG-single-chain TRAIL fusion proteins for tumour therapy. Sci Rep 8, 7808. https://doi.org/10.1038/s41598-018-24450-8

Siegle, L., Schwab, J.D., Kühlwein, S.D., Lausser, L., Tümpel, S., Pfister, A.S., Kühl, M., Kestler, H.A., 2018. A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells. PLoS ONE 13, e0195126. https://doi.org/10.1371/journal.pone.0195126

Silbernagel, N., Walecki, M., Schäfer, M.K.-H., Kessler, M., Zobeiri, M., Rinné, S., Kiper, A.K., Komadowski, M.A., Vowinkel, K.S., Wemhöner, K., Fortmüller, L., Schewe, M., Dolga, A.M., Scekic-Zahirovic, J., Matschke, L.A., Culmsee, C., Baukrowitz, T., Monassier, L., Ullrich, N.D., Dupuis, L., Just, S., Budde, T., Fabritz, L., Decher, N., 2018. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. fj201800246R. https://doi.org/10.1096/fj.201800246R

Sorokin, D.V., Peterlik, I., Tektonidis, M., Rohr, K., Matula, P., 2018. Non-Rigid Contour-Based Registration of Cell Nuclei in 2-D Live Cell Microscopy Images Using a Dynamic Elasticity Model. IEEE Trans Med Imaging 37, 173–184. https://doi.org/10.1109/TMI.2017.2734169

Spechler, P.A., Allgaier, N., Chaarani, B., Whelan, R., Watts, R., Orr, C., Albaugh, M.D., D’Alberto, N., Higgins, S.T., Hudson, K.E., Mackey, S., Potter, A., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Martinot, M.-L.P., Nees, F., Orfanos, D.P., Paus, T., Smolka, M.N., Walter, H., Schumann, G., Althoff, R.R., Garavan, H., IMAGEN Consortium, 2018. The Initiation of Cannabis Use in Adolescence is Predicted by Sex-Specific Psychosocial and Neurobiological Features. Eur. J. Neurosci. https://doi.org/10.1111/ejn.13989

Stapor, P., Weindl, D., Ballnus, B., Hug, S., Loos, C., Fiedler, A., Krause, S., Hroß, S., Fröhlich, F., Hasenauer, J., Wren, J., 2018. PESTO: Parameter EStimation TOolbox. Bioinformatics 34, 705–707. https://doi.org/10.1093/bioinformatics/btx676

Stasik, S., Schuster, C., Ortlepp, C., Platzbecker, U., Bornhäuser, M., Schetelig, J., Ehninger, G., Folprecht, G., Thiede, C., 2018. An optimized targeted Next-Generation Sequencing approach for sensitive detection of single nucleotide variants. Biomol Detect Quantif 15, 6–12. https://doi.org/10.1016/j.bdq.2017.12.001

Stoyan, D., Pommerening, A., Hummel, M., Kopp-Schneider, A., 2018. Multiple-rater kappas for binary data: Models and interpretation. Biom J 60, 381–394. https://doi.org/10.1002/bimj.201600267

Streit, F., Treutlein, J., Frischknecht, U., Hermann, D., Mann, K., Kiefer, F., Sack, M., Hall, A.S.M., Frank, J., Witt, S.H., Foo, J.C., Degenhardt, F., Heilmann-Heimbach, S., Nöthen, M.M., Sommer, W.H., Spanagel, R., Rietschel, M., Ende, G., 2018. Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes. Psychiatr. Genet. 28, 94–95. https://doi.org/10.1097/YPG.0000000000000202

Stuke, H., Weilnhammer, V.A., Sterzer, P., Schmack, K., 2018. Delusion Proneness is Linked to a Reduced Usage of Prior Beliefs in Perceptual Decisions. Schizophr Bull. https://doi.org/10.1093/schbul/sbx189

Sun, N., Wu, Y., Nanba, K., Sbiera, S., Kircher, S., Kunzke, T., Aichler, M., Berezowska, S., Reibetanz, J., Rainey, W.E., Fassnacht, M., Walch, A., Kroiss, M., 2018. High resolution tissue mass spectrometry imaging reveals a refined functional anatomy of the human adult adrenal gland. Endocrinology. https://doi.org/10.1210/en.2018-00064

Suttorp, M., Schulze, P., Glauche, I., Göhring, G., von Neuhoff, N., Metzler, M., Sedlacek, P., de Bont, E.S.J.M., Balduzzi, A., Lausen, B., Aleinikova, O., Sufliarska, S., Henze, G., Strauss, G., Eggert, A., Kremens, B., Groll, A.H., Berthold, F., Klein, C., Groß-Wieltsch, U., Sykora, K.W., Borkhardt, A., Kulozik, A.E., Schrappe, M., Nowasz, C., Krumbholz, M., Tauer, J.T., Claviez, A., Harbott, J., Kreipe, H.H., Schlegelberger, B., Thiede, C., 2018. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial. Leukemia. https://doi.org/10.1038/s41375-018-0179-9

Tesch, R., Becker, C., Müller, M.P., Beck, M.E., Quambusch, L., Getlik, M., Lategahn, J., Uhlenbrock, N., Costa, F.N., Polêto, M.D., de Sena Murteira Pinheiro, P., Rodrigues, D.A., Sant’Anna, C.M.R., Ferreira, F.F., Verli, H., Fraga, C.A.M., Rauh, D., 2018. An Unusual Intramolecular Halogen Bond Guides Conformational Selection. Angew. Chem. Int. Ed. Engl. https://doi.org/10.1002/anie.201804917

Thingholm, L., Rühlemann, M., Wang, J., Hübenthal, M., Lieb, W., Laudes, M., Franke, A., D’Amato, M., 2018. Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. Gut. https://doi.org/10.1136/gutjnl-2017-315841

Thürmann, L., Grützmann, K., Klös, M., Bieg, M., Winter, M., Polte, T., Bauer, T., Schick, M., Bewerunge-Hudler, M., Röder, S., Bauer, M., Wissenbach, D.K., Sack, U., Weichenhan, D., Mücke, O., Plass, C., Borte, M., von Bergen, M., Lehmann, I., Eils, R., Trump, S., 2018. Early-onset childhood atopic dermatitis is related to NLRP2 repression. J. Allergy Clin. Immunol. 141, 1482-1485.e16. https://doi.org/10.1016/j.jaci.2017.11.018

Trepte, P., Kruse, S., Kostova, S., Hoffmann, S., Buntru, A., Tempelmeier, A., Secker, C., Diez, L., Schulz, A., Klockmeier, K., Zenkner, M., Golusik, S., Rau, K., Schnoegl, S., Garner, C.C., Wanker, E.E., 2018. LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Mol. Syst. Biol. 14, e8071.

Treutlein, J., Spanagel, R., 2018. Genetische Aspekte bei Alkoholismus. Biospektrum 24, 260–263. https://doi.org/10.1007/s12268-018-0916-7

Urban, C., Buck, A., Siveke, J.T., Lordick, F., Luber, B., Walch, A., Aichler, M., 2018. PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI. Biochim. Biophys. Acta 1862, 51–60. https://doi.org/10.1016/j.bbagen.2017.10.005

Van der Auwera, S., Peyrot, W.J., Milaneschi, Y., Hertel, J., Baune, B., Breen, G., Byrne, E., Dunn, E.C., Fisher, H., Homuth, G., Levinson, D., Lewis, C., Mills, N., Mullins, N., Nauck, M., Pistis, G., Preisig, M., Rietschel, M., Ripke, S., Sullivan, P., Teumer, A., Völzke, H., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Boomsma, D.I., Wray, N.R., Penninx, B., Grabe, H., 2018. Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD. Am. J. Med. Genet. B Neuropsychiatr. Genet. 177, 40–49. https://doi.org/10.1002/ajmg.b.32593

Velthorst, E., Froudist-Walsh, S., Stahl, E., Ruderfer, D., Ivanov, I., Buxbaum, J., 2018. Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis. Transl Psychiatry 8. https://doi.org/10.1038/s41398-018-0229-0

Vengeliene, V., Takahashi, T.T., Dravolina, O.A., Belozertseva, I., Zvartau, E., Bespalov, A.Y., Spanagel, R., 2018. Efficacy and side effects of baclofen and the novel GABAB receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction. Psychopharmacology (Berl.) 235, 1955–1965. https://doi.org/10.1007/s00213-018-4893-9

Vera, J., Santos, G., 2018. Can Gamification Contribute to Computer Modeling-Driven Biomedical Research? Front Physiol 9, 908. https://doi.org/10.3389/fphys.2018.00908

Viau, A., Bienaimé, F., Lukas, K., Todkar, A.P., Knoll, M., Yakulov, T.A., Hofherr, A., Kretz, O., Helmstädter, M., Reichardt, W., Braeg, S., Aschman, T., Merkle, A., Pfeifer, D., Dumit, V.I., Gubler, M.-C., Nitschke, R., Huber, T.B., Terzi, F., Dengjel, J., Grahammer, F., Köttgen, M., Busch, H., Boerries, M., Walz, G., Triantafyllopoulou, A., Kuehn, E.W., 2018. Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney. EMBO J. 37. https://doi.org/10.15252/embj.201798615

Vieta, E., Berk, M., Schulze, T.G., Carvalho, A.F., Suppes, T., Calabrese, J.R., Gao, K., Miskowiak, K.W., Grande, I., 2018. Bipolar disorders. Nat Rev Dis Primers 4, 18008. https://doi.org/10.1038/nrdp.2018.8

Vogel, B.O., Lett, T.A., Erk, S., Mohnke, S., Wackerhagen, C., Brandl, E.J., Romanczuk-Seiferth, N., Otto, K., Schweiger, J.I., Tost, H., Nöthen, M.M., Rietschel, M., Degenhardt, F., Witt, S.H., Meyer-Lindenberg, A., Heinz, A., Walter, H., 2018. The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis. Schizophr. Res. 195, 190–196. https://doi.org/10.1016/j.schres.2017.09.030

Weilnhammer, V.A., Stuke, H., Sterzer, P., Schmack, K., 2018. The Neural Correlates of Hierarchical Predictions for Perceptual Decisions. J. Neurosci. 38, 5008–5021. https://doi.org/10.1523/JNEUROSCI.2901-17.2018

Went, M., Sud, A., Försti, A., Halvarsson, B.-M., Weinhold, N., Kimber, S., van Duin, M., Thorleifsson, G., Holroyd, A., Johnson, D.C., Li, N., Orlando, G., Law, P.J., Ali, M., Chen, B., Mitchell, J.S., Gudbjartsson, D.F., Kuiper, R., Stephens, O.W., Bertsch, U., Broderick, P., Campo, C., Bandapalli, O.R., Einsele, H., Gregory, W.A., Gullberg, U., Hillengass, J., Hoffmann, P., Jackson, G.H., Jöckel, K.-H., Johnsson, E., Kristinsson, S.Y., Mellqvist, U.-H., Nahi, H., Easton, D., Pharoah, P., Dunning, A., Peto, J., Canzian, F., Swerdlow, A., Eeles, R.A., Kote-Jarai, Zs., Muir, K., Pashayan, N., Nickel, J., Nöthen, M.M., Rafnar, T., Ross, F.M., da Silva Filho, M.I., Thomsen, H., Turesson, I., Vangsted, A., Andersen, N.F., Waage, A., Walker, B.A., Wihlborg, A.-K., Broyl, A., Davies, F.E., Thorsteinsdottir, U., Langer, C., Hansson, M., Goldschmidt, H., Kaiser, M., Sonneveld, P., Stefansson, K., Morgan, G.J., Hemminki, K., Nilsson, B., Houlston, R.S., PRACTICAL consortium, 2018. Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Nat Commun 9, 3707. https://doi.org/10.1038/s41467-018-04989-w

Wiedemann, B., Weisner, J., Rauh, D., 2018. Chemical modulation of transcription factors. Medchemcomm 9, 1249–1272. https://doi.org/10.1039/c8md00273h

Wierer, M., Prestel, M., Schiller, H.B., Yan, G., Schaab, C., Azghandi, S., Werner, J., Kessler, T., Malik, R., Murgia, M., Aherrahrou, Z., Schunkert, H., Dichgans, M., Mann, M., 2018. Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression. Mol. Cell Proteomics 17, 321–334. https://doi.org/10.1074/mcp.RA117.000315

Wirthschaft, P., Bode, J., Simon, A.E.M., Hoffmann, E., van Laack, R., Krüwel, T., Dietrich, F., Bucher, D., Hahn, A., Sahm, F., Breckwoldt, M.O., Kurz, F.T., Hielscher, T., Fischer, B., Dross, N., Ruiz de Almodovar, C., von Deimling, A., Herold-Mende, C., Plass, C., Boulant, S., Wiestler, B., Reifenberger, G., Lichter, P., Wick, W., Tews, B., 2018. A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas. Int. J. Cancer. https://doi.org/10.1002/ijc.31404

Witt, S.H., Frank, J., Gilles, M., Lang, M., Treutlein, J., Streit, F., Wolf, I.A.C., Peus, V., Scharnholz, B., Send, T.S., Heilmann-Heimbach, S., Sivalingam, S., Dukal, H., Strohmaier, J., Sütterlin, M., Arloth, J., Laucht, M., Nöthen, M.M., Deuschle, M., Rietschel, M., 2018. Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation. BMC Genomics 19, 290. https://doi.org/10.1186/s12864-018-4652-7

Wobst, J., Schunkert, H., Kessler, T., 2018. Genetic alterations in the NO-cGMP pathway and cardiovascular risk. Nitric Oxide 76, 105–112. https://doi.org/10.1016/j.niox.2018.03.019

Wolff, A., Bayerlová, M., Gaedcke, J., Kube, D., Beißbarth, T., 2018. A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells. PLoS ONE 13, e0197162. https://doi.org/10.1371/journal.pone.0197162

Wolk, K., Frambach, Y., Jacobi, A., Wilsmann-Theis, D., Phillipp, S., Witte-Händel, E., Wenzel, J., Mössner, R., Sabat, R., 2018. Increased levels of lipocalin 2 in palmoplantar pustular psoriasis. J. Dermatol. Sci. 90, 68–74. https://doi.org/10.1016/j.jdermsci.2017.12.018

Wolle, P., Müller, M.P., Rauh, D., 2018a. Augmented Reality in Scientific Publications-Taking the Visualization of 3D Structures to the Next Level. ACS Chem. Biol. 13, 496–499. https://doi.org/10.1021/acschembio.8b00153

Wolle, P., Weisner, J., Keul, M., Landel, I., Lategahn, J., Rauh, D., 2018b. RASPELD to Perform High-End Screening in an Academic Environment Toward the Development of Cancer Therapeutics. ChemMedChem. https://doi.org/10.1002/cmdc.201800477

Worth, L., Michel, S., Gaertner, V.D., Kabesch, M., Schieck, M., 2018. Asthma- and IgE-associated polymorphisms affect expression of TH 17 genes. Allergy 73, 1342–1347. https://doi.org/10.1111/all.13422

Wray, N.R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E.M., Abdellaoui, A., Adams, M.J., Agerbo, E., Air, T.M., Andlauer, T.M.F., Bacanu, S.-A., Bækvad-Hansen, M., Beekman, A.F.T., Bigdeli, T.B., Binder, E.B., Blackwood, D.R.H., Bryois, J., Buttenschøn, H.N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J.H., Clarke, T.-K., Coleman, J.I.R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G.E., Crowley, C.A., Dashti, H.S., Davies, G., Deary, I.J., Degenhardt, F., Derks, E.M., Direk, N., Dolan, C.V., Dunn, E.C., Eley, T.C., Eriksson, N., Escott-Price, V., Kiadeh, F.H.F., Finucane, H.K., Forstner, A.J., Frank, J., Gaspar, H.A., Gill, M., Giusti-Rodríguez, P., Goes, F.S., Gordon, S.D., Grove, J., Hall, L.S., Hannon, E., Hansen, C.S., Hansen, T.F., Herms, S., Hickie, I.B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J.-J., Hougaard, D.M., Hu, M., Hyde, C.L., Ising, M., Jansen, R., Jin, F., Jorgenson, E., Knowles, J.A., Kohane, I.S., Kraft, J., Kretzschmar, W.W., Krogh, J., Kutalik, Z., Lane, J.M., Li, Yihan, Li, Yun, Lind, P.A., Liu, X., Lu, L., MacIntyre, D.J., MacKinnon, D.F., Maier, R.M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S.E., Mehta, D., Middeldorp, C.M., Mihailov, E., Milaneschi, Y., Milani, L., Mill, J., Mondimore, F.M., Montgomery, G.W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M.G., Nyholt, D.R., O’Reilly, P.F., Oskarsson, H., Owen, M.J., Painter, J.N., Pedersen, C.B., Pedersen, M.G., Peterson, R.E., Pettersson, E., Peyrot, W.J., Pistis, G., Posthuma, D., Purcell, S.M., Quiroz, J.A., Qvist, P., Rice, J.P., Riley, B.P., Rivera, M., Saeed Mirza, S., Saxena, R., Schoevers, R., Schulte, E.C., Shen, L., Shi, J., Shyn, S.I., Sigurdsson, E., Sinnamon, G.B.C., Smit, J.H., Smith, D.J., Stefansson, H., Steinberg, S., Stockmeier, C.A., Streit, F., Strohmaier, J., Tansey, K.E., Teismann, H., Teumer, A., Thompson, W., Thomson, P.A., Thorgeirsson, T.E., Tian, C., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A.G., Umbricht, D., Van der Auwera, S., van Hemert, A.M., Viktorin, A., Visscher, P.M., Wang, Y., Webb, B.T., Weinsheimer, S.M., Wellmann, J., Willemsen, G., Witt, S.H., Wu, Y., Xi, H.S., Yang, J., Zhang, F., eQTLGen, 23andMe, Arolt, V., Baune, B.T., Berger, K., Boomsma, D.I., Cichon, S., Dannlowski, U., de Geus, E.C.J., DePaulo, J.R., Domenici, E., Domschke, K., Esko, T., Grabe, H.J., Hamilton, S.P., Hayward, C., Heath, A.C., Hinds, D.A., Kendler, K.S., Kloiber, S., Lewis, G., Li, Q.S., Lucae, S., Madden, P.F.A., Magnusson, P.K., Martin, N.G., McIntosh, A.M., Metspalu, A., Mors, O., Mortensen, P.B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M.M., O’Donovan, M.C., Paciga, S.A., Pedersen, N.L., Penninx, B.W.J.H., Perlis, R.H., Porteous, D.J., Potash, J.B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T.G., Smoller, J.W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M.M., Werge, T., Winslow, A.R., Lewis, C.M., Levinson, D.F., Breen, G., Børglum, A.D., Sullivan, P.F., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 2018. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. https://doi.org/10.1038/s41588-018-0090-3

Yadav, P., Merz, M., Mai, E.K., Försti, A., Jauch, A., Goldschmidt, H., Hemminki, K., 2018. Cytogenetic aberrations in multiple myeloma are associated with shifts in serum immunoglobulin isotypes distribution and levels. Haematologica 103, e162–e164. https://doi.org/10.3324/haematol.2017.184226

Yakulov, T.A., Todkar, A.P., Slanchev, K., Wiegel, J., Bona, A., Groß, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T.B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., de Tullio, P., Jouret, F., Kramer-Zucker, A., Walz, G., 2018. CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nat Commun 9, 3660. https://doi.org/10.1038/s41467-018-06094-4

Yan, X., Wang, Z., Schmidt, V., Gauert, A., Willnow, T.E., Heinig, M., Poy, M.N., 2018. Cadm2 regulates body weight and energy homeostasis in mice. Mol Metab 8, 180–188. https://doi.org/10.1016/j.molmet.2017.11.010

Yépez, V.A., Kremer, L.S., Iuso, A., Gusic, M., Kopajtich, R., Koňaříková, E., Nadel, A., Wachutka, L., Prokisch, H., Gagneur, J., 2018. OCR-Stats: Robust estimation and statistical testing of mitochondrial respiration activities using Seahorse XF Analyzer. PLoS ONE 13, e0199938. https://doi.org/10.1371/journal.pone.0199938

Zacharias, H.U., Altenbuchinger, M., Gronwald, W., 2018. Statistical Analysis of NMR Metabolic Fingerprints: Established Methods and Recent Advances. Metabolites 8. https://doi.org/10.3390/metabo8030047

Zeissig, S., Rosati, E., Dowds, C.M., Aden, K., Bethge, J., Schulte, B., Pan, W.H., Mishra, N., Zuhayra, M., Marx, M., Paulsen, M., Strigli, A., Conrad, C., Schuldt, D., Sinha, A., Ebsen, H., Kornell, S.-C., Nikolaus, S., Arlt, A., Kabelitz, D., Ellrichmann, M., Lützen, U., Rosenstiel, P.C., Franke, A., Schreiber, S., 2018. Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease. Gut. https://doi.org/10.1136/gutjnl-2018-316023

Zhou, Q., Maleck, C., von Ungern-Sternberg, S.N.I., Neupane, B., Heinzmann, D., Marquardt, J., Duckheim, M., Scheckenbach, C., Stimpfle, F., Gawaz, M., Schreieck, J., Seizer, P., Gramlich, M., 2018. Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation. Circ Arrhythm Electrophysiol 11, e006242. https://doi.org/10.1161/CIRCEP.118.006242

Zhu, C., Miller, M., Marpaka, S., Vaysberg, P., Rühlemann, M.C., Wu, G., Heinsen, F.-A., Tempel, M., Zhao, L., Lieb, W., Franke, A., Bromberg, Y., 2018. Functional sequencing read annotation for high precision microbiome analysis. Nucleic Acids Res. 46, e23. https://doi.org/10.1093/nar/gkx1209

Ziller, M.J., Ortega, J.A., Quinlan, K.A., Santos, D.P., Gu, H., Martin, E.J., Galonska, C., Pop, R., Maidl, S., Di Pardo, A., Huang, M., Meltzer, H.Y., Gnirke, A., Heckman, C.J., Meissner, A., Kiskinis, E., 2018. Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology. Cell Stem Cell. https://doi.org/10.1016/j.stem.2018.02.012

Zimprich, A., Östereicher, M.A., Becker, L., Dirscherl, P., Ernst, L., Fuchs, H., Gailus-Durner, V., Garrett, L., Giesert, F., Glasl, L., Hummel, A., Rozman, J., de Angelis, M.H., Vogt-Weisenhorn, D., Wurst, W., Hölter, S.M., 2018. Analysis of locomotor behavior in the German Mouse Clinic. J. Neurosci. Methods 300, 77–91. https://doi.org/10.1016/j.jneumeth.2017.05.005

2017

Agís-Balboa, R.C., Pinheiro, P.S., Rebola, N., Kerimoglu, C., Benito, E., Gertig, M., Bahari-Javan, S., Jain, G., Burkhardt, S., Delalle, I., Jatzko, A., Dettenhofer, M., Zunszain, P.A., Schmitt, A., Falkai, P., Pape, J.C., Binder, E.B., Mulle, C., Fischer, A., Sananbenesi, F., 2017. Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia. EMBO J. 36, 2815–2828. doi.org/10.15252/embj.201796821

Aichler, M., Borgmann, D., Krumsiek, J., Buck, A., MacDonald, P.E., Fox, J.E.M., Lyon, J., Light, P.E., Keipert, S., Jastroch, M., Feuchtinger, A., Mueller, N.S., Sun, N., Palmer, A., Alexandrov, T., Hrabe de Angelis, M., Neschen, S., Tschöp, M.H., Walch, A., 2017. N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell Metab. 25, 1334–1347.e4. doi.org/10.1016/j.cmet.2017.04.012

Ait-El-Mkadem, S., Dayem-Quere, M., Gusic, M., Chaussenot, A., Bannwarth, S., François, B., Genin, E.C., Fragaki, K., Volker-Touw, C.L.M., Vasnier, C., Serre, V., van Gassen, K.L.I., Lespinasse, F., Richter, S., Eisenhofer, G., Rouzier, C., Mochel, F., De Saint-Martin, A., Abi Warde, M.-T., de Sain-van der Velde, M.G.M., Jans, J.J.M., Amiel, J., Avsec, Z., Mertes, C., Haack, T.B., Strom, T., Meitinger, T., Bonnen, P.E., Taylor, R.W., Gagneur, J., van Hasselt, P.M., Rötig, A., Delahodde, A., Prokisch, H., Fuchs, S.A., Paquis-Flucklinger, V., 2017. Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy. Am. J. Hum. Genet. 100, 151–159. doi.org/10.1016/j.ajhg.2016.11.014

Albaugh, M.D., Orr, C., Chaarani, B., Althoff, R.R., Allgaier, N., D’Alberto, N., Hudson, K., Mackey, S., Spechler, P.A., Banaschewski, T., Brühl, R., Bokde, A.L.W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Goodman, R., Gowland, P., Grimmer, Y., Heinz, A., Kappel, V., Martinot, J.-L., Paillère Martinot, M.-L., Nees, F., Orfanos, D.P., Penttila, J., Poustka, L., Paus, T., Smolka, M.N., Struve, M., Walter, H., Whelan, R., Schumann, G., Garavan, H., Potter, A.S., 2017. Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents. Biol. Psychiatry 82, 660–668. doi.org/10.1016/j.biopsych.2017.01.003

Albert, S., Messer, M., Schiemann, J., Roeper, J., Schneider, G., 2017a. Multi-Scale Detection of Variance Changes in Renewal Processes in the Presence of Rate Change Points. Journal of Time Series Analysis 38, 1028–1052. doi.org/10.1111/jtsa.12254

Albert, S., Schmack, K., Sterzer, P., Schneider, G., 2017b. A hierarchical stochastic model for bistable perception. PLoS Comput. Biol. 13, e1005856. doi.org/10.1371/journal.pcbi.1005856

Alfonso, J.C.L., Talkenberger, K., Seifert, M., Klink, B., Hawkins-Daarud, A., Swanson, K.R., Hatzikirou, H., Deutsch, A., 2017. The biology and mathematical modelling of glioma invasion: a review. J R Soc Interface 14. doi.org/10.1098/rsif.2017.0490

Altenbuchinger, M., Schwarzfischer, P., Rehberg, T., Reinders, J., Kohler, C.W., Gronwald, W., Richter, J., Szczepanowski, M., Masqué-Soler, N., Klapper, W., Oefner, P.J., Spang, R., 2017. Molecular signatures that can be transferred across different omics platforms. Bioinformatics 33, i333–i340. doi.org/10.1093/bioinformatics/btx241

Amer, W., Toth, C., Vassella, E., Meinrath, J., Koitzsch, U., Arens, A., Huang, J., Eischeid, H., Adam, A., Buettner, R., Scheel, A., Schaefer, S.C., Odenthal, M., 2017. Evolution analysis of heterogeneous non-small cell lung carcinoma by ultra-deep sequencing of the mitochondrial genome. Sci Rep 7, 11069. doi.org/10.1038/s41598-017-11345-3

Arakelyan, A., Nersisyan, L., Poghosyan, D., Khondkaryan, L., Hakobyan, A., Löffler-Wirth, H., Melanitou, E., Binder, H., 2017. Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles. PLoS ONE 12, e0187572. doi.org/10.1371/journal.pone.0187572

Ashrafi, A., Garcia, P., Kollmus, H., Schughart, K., Del Sol, A., Buttini, M., Glaab, E., 2017. Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson’s disease. Neurobiol. Aging 58, 30–33. doi.org/10.1016/j.neurobiolaging.2017.06.008

Aukema, S.M., van Pel, R., Nagel, I., Bens, S., Siebert, R., Rosati, S., van den Berg, E., Bosga-Bouwer, A.G., Kibbelaar, R.E., Hoogendoorn, M., van Imhoff, G.W., Kluin-Nelemans, H.C., Kluin, P.M., Nijland, M., 2017. MYC expression and translocation analyses in low-grade and transformed follicular lymphoma. Histopathology 71, 960–971. doi.org/10.1111/his.13316

Bach, P., Zois, V., Vollstädt-Klein, S., Kirsch, M., Hoffmann, S., Jorde, A., Frank, J., Charlet, K., Treutlein, J., Beck, A., Heinz, A., Walter, H., Rietschel, M., Kiefer, F., 2017. Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk. Addict Biol. doi.org/10.1111/adb.12571

Badenes, S.M., Fernandes, T.G., Miranda, C.C., Pusch‐Klein, A., Haupt, S., Rodrigues, C.A., Diogo, M.M., Brüstle, O., Cabral, J.M., 2017. Long‐term expansion of human induced pluripotent stem cells in a microcarrier‐based dynamic system. Journal of Chemical Technology and Biotechnology 92, 492–503. doi.org/10.1002/jctb.5074

Baldow, C., Salentin, S., Schroeder, M., Roeder, I., Glauche, I., 2017. MAGPIE: Simplifying access and execution of computational models in the life sciences. PLoS Comput. Biol. 13, e1005898. doi.org/10.1371/journal.pcbi.1005898

Ballnus, B., Hug, S., Hatz, K., Görlitz, L., Hasenauer, J., Theis, F.J., 2017. Comprehensive benchmarking of Markov chain Monte Carlo methods for dynamical systems. BMC Syst Biol 11, 63. doi.org/10.1186/s12918-017-0433-1

Barrow, T.M., Klett, H., Toth, R., Böhm, J., Gigic, B., Habermann, N., Scherer, D., Schrotz-King, P., Skender, S., Abbenhardt-Martin, C., Zielske, L., Schneider, M., Ulrich, A., Schirmacher, P., Herpel, E., Brenner, H., Busch, H., Boerries, M., Ulrich, C.M., Michels, K.B., 2017. Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study. J. Pathol. 243, 366–375. doi.org/10.1002/path.4955

Bartholdy, S., Allen, K., Hodsoll, J., O’Daly, O.G., Campbell, I.C., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Quinlan, E.B., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Heinz, A., Ittermann, B., Martinot, J.-L., Artiges, E., Nees, F., Orfanos, D.P., Paus, T., Poustka, L., Smolka, M.N., Mennigen, E., Walter, H., Whelan, R., Schumann, G., Schmidt, U., 2017. Identifying disordered eating behaviours in adolescents: how do parent and adolescent reports differ by sex and age? Eur Child Adolesc Psychiatry 26, 691–701. doi.org/10.1007/s00787-016-0935-1

Bauer, C.R., Knecht, C., Fretter, C., Baum, B., Jendrossek, S., Rühlemann, M., Heinsen, F.-A., Umbach, N., Grimbacher, B., Franke, A., Lieb, W., Krawczak, M., Hütt, M.-T., Sax, U., 2017. Interdisciplinary approach towards a systems medicine toolbox using the example of inflammatory diseases. Brief. Bioinformatics 18, 479–487. doi.org/10.1093/bib/bbw024

Baum, B., Bauer, C., Franke, T., Kusch, H., Parciak, M., Rottmann, T., Umbach, N., Sax, U., 2017. Opinion paper: Data provenance challenges in biomedical research. it - Information Technology.

Baumgart, S., Peddinghaus, A., Schulte-Wrede, U., Mei, H.E., Grützkau, A., 2017a. OMIP-034: Comprehensive immune phenotyping of human peripheral leukocytes by mass cytometry for monitoring immunomodulatory therapies. Cytometry A 91, 34–38. doi.org/10.1002/cyto.a.22894

Baumgart, S., Schulz, A.R., Peddinghaus, A., Stanislawiak, S., Gillert, S., Hirseland, H., Krauthäuser, S., Dose, C., Mei, H.E., Grützkau, A., 2017b. Dual-labelled antibodies for flow and mass cytometry: A new tool for cross-platform comparison and enrichment of target cells for mass cytometry. Eur. J. Immunol. 47, 1377–1385. doi.org/10.1002/eji.201747031

Becker, A., Kirsch, M., Gerchen, M.F., Kiefer, F., Kirsch, P., 2017. Striatal activation and frontostriatal connectivity during non-drug reward anticipation in alcohol dependence. Addict Biol 22, 833–843. doi.org/10.1111/adb.12352

Bedenk, B.T., Almeida-Corrêa, S., Jurik, A., Dedic, N., Grünecker, B., Genewsky, A.J., Kaltwasser, S.F., Riebe, C.J., Deussing, J.M., Czisch, M., Wotjak, C.T., 2017. Mn2+ dynamics in manganese-enhanced MRI (MEMRI): Cav1.2 channel-mediated uptake and preferential accumulation in projection terminals. Neuroimage 169, 374–382. doi.org/10.1016/j.neuroimage.2017.12.054

Benary, U., Wolf, E., Wolf, J., 2017. Mathematical modelling of promoter occupancies in MYC-dependent gene regulation. Genomics and Computational Biology 3, 54. doi.org/10.18547/gcb.2017.vol3.iss2.e54

Benedetti, E., Pučić-Baković, M., Keser, T., Wahl, A., Hassinen, A., Yang, J.-Y., Liu, L., Trbojević-Akmačić, I., Razdorov, G., Štambuk, J., Klarić, L., Ugrina, I., Selman, M.H.J., Wuhrer, M., Rudan, I., Polasek, O., Hayward, C., Grallert, H., Strauch, K., Peters, A., Meitinger, T., Gieger, C., Vilaj, M., Boons, G.-J., Moremen, K.W., Ovchinnikova, T., Bovin, N., Kellokumpu, S., Theis, F.J., Lauc, G., Krumsiek, J., 2017. Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Nat Commun 8, 1483. doi.org/10.1038/s41467-017-01525-0

Bernardi, R.E., Broccoli, L., Hirth, N., Justice, N.J., Deussing, J.M., Hansson, A.C., Spanagel, R., 2017. Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior. Front Behav Neurosci 11, 221. doi.org/10.3389/fnbeh.2017.00221

Bernhardt, S., Bayerlová, M., Vetter, M., Wachter, A., Mitra, D., Hanf, V., Lantzsch, T., Uleer, C., Peschel, S., John, J., Buchmann, J., Weigert, E., Bürrig, K.-F., Thomssen, C., Korf, U., Beissbarth, T., Wiemann, S., Kantelhardt, E.J., 2017. Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors. Breast Cancer Res. 19, 112. doi.org/10.1186/s13058-017-0905-7

Beylergil, S.B., Beck, A., Deserno, L., Lorenz, R.C., Rapp, M.A., Schlagenhauf, F., Heinz, A., Obermayer, K., 2017. Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence. NeuroImage: Clinical. doi.org/10.1016/j.nicl.2017.04.010

Bigdeli, T.B., Ripke, S., Peterson, R.E., Trzaskowski, M., Bacanu, S.-A., Abdellaoui, A., Andlauer, T.F.M., Beekman, A.T.F., Berger, K., Blackwood, D.H.R., Boomsma, D.I., Breen, G., Buttenschøn, H.N., Byrne, E.M., Cichon, S., Clarke, T.-K., Couvy-Duchesne, B., Craddock, N., de Geus, E.J.C., Degenhardt, F., Dunn, E.C., Edwards, A.C., Fanous, A.H., Forstner, A.J., Frank, J., Gill, M., Gordon, S.D., Grabe, H.J., Hamilton, S.P., Hardiman, O., Hayward, C., Heath, A.C., Henders, A.K., Herms, S., Hickie, I.B., Hoffmann, P., Homuth, G., Hottenga, J.-J., Ising, M., Jansen, R., Kloiber, S., Knowles, J.A., Lang, M., Li, Q.S., Lucae, S., MacIntyre, D.J., Madden, P. a. F., Martin, N.G., McGrath, P.J., McGuffin, P., McIntosh, A.M., Medland, S.E., Mehta, D., Middeldorp, C.M., Milaneschi, Y., Montgomery, G.W., Mors, O., Müller-Myhsok, B., Nauck, M., Nyholt, D.R., Nöthen, M.M., Owen, M.J., Penninx, B.W.J.H., Pergadia, M.L., Perlis, R.H., Peyrot, W.J., Porteous, D.J., Potash, J.B., Rice, J.P., Rietschel, M., Riley, B.P., Rivera, M., Schoevers, R., Schulze, T.G., Shi, J., Shyn, S.I., Smit, J.H., Smoller, J.W., Streit, F., Strohmaier, J., Teumer, A., Treutlein, J., Van der Auwera, S., van Grootheest, G., van Hemert, A.M., Völzke, H., Webb, B.T., Weissman, M.M., Wellmann, J., Willemsen, G., Witt, S.H., Levinson, D.F., Lewis, C.M., Wray, N.R., Flint, J., Sullivan, P.F., Kendler, K.S., 2017. Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry 7, e1074. doi.org/10.1038/tp.2016.292

Bilek, E., Stößel, G., Schäfer, A., Clement, L., Ruf, M., Robnik, L., Neukel, C., Tost, H., Kirsch, P., Meyer-Lindenberg, A., 2017. State-Dependent Cross-Brain Information Flow in Borderline Personality Disorder. JAMA Psychiatry 74, 949–957. doi.org/10.1001/jamapsychiatry.2017.1682

Bott, A., Erdem, N., Lerrer, S., Hotz-Wagenblatt, A., Breunig, C., Abnaof, K., Wörner, A., Wilhelm, H., Münstermann, E., Ben-Baruch, A., Wiemann, S., 2017. miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget 8, 43897–43914. doi.org/10.18632/oncotarget.14915

Brænne, I., Zeng, L., Willenborg, C., Tragante, V., Kessler, T., CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Willer, C.J., Laakso, M., Wallentin, L., Franks, P.W., Salomaa, V., Dehghan, A., Meitinger, T., Samani, N.J., Asselbergs, F.W., Erdmann, J., Schunkert, H., 2017. Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. PLoS ONE 12, e0182999. doi.org/10.1371/journal.pone.0182999

Brägelmann, J., Böhm, S., Guthrie, M.R., Mollaoglu, G., Oliver, T.G., Sos, M.L., 2017a. Family matters: How MYC family oncogenes impact small cell lung cancer. Cell Cycle 16, 1489–1498. doi.org/10.1080/15384101.2017.1339849

Brägelmann, J., Dammert, M.A., Dietlein, F., Heuckmann, J.M., Choidas, A., Böhm, S., Richters, A., Basu, D., Tischler, V., Lorenz, C., Habenberger, P., Fang, Z., Ortiz-Cuaran, S., Leenders, F., Eickhoff, J., Koch, U., Getlik, M., Termathe, M., Sallouh, M., Greff, Z., Varga, Z., Balke-Want, H., French, C.A., Peifer, M., Reinhardt, H.C., Örfi, L., Kéri, G., Ansén, S., Heukamp, L.C., Büttner, R., Rauh, D., Klebl, B.M., Thomas, R.K., Sos, M.L., 2017b. Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma. Cell Reports 20, 2833–2845. doi.org/10.1016/j.celrep.2017.08.082

Braun, D.M., Chung, I., Kepper, N., Rippe, K., 2017. TelNet - a database for human and yeast genes involved in telomere maintenance. bioRxiv 130153. doi.org/10.1101/130153

Bublitz, S.K., Alhaddad, B., Synofzik, M., Kuhl, V., Lindner, A., Freiberg, C., Schmidt, H., Strom, T.M., Haack, T.B., Deschauer, M., 2017. Expanding the phenotype of DNAJC3 mutations: A case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration. Clin. Genet. 92, 561–562. doi.org/10.1111/cge.13069

Bührmann, M., Wiedemann, B.M., Müller, M.P., Hardick, J., Ecke, M., Rauh, D., 2017. Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK. PLoS ONE 12, e0184627. doi.org/10.1371/journal.pone.0184627

Büttner, R., Wolf, J., Thomas, R.K., Sos, M.L., 2017. Resistance Mechanisms to AZD9291 and Rociletinib-Response. Clin. Cancer Res. 23, 3967–3968. doi.org/10.1158/1078-0432.CCR-17-0948

Café-Mendes, C.C., Ferro, E.S., Torrão, A.S., Crunfli, F., Rioli, V., Schmitt, A., Falkai, P., Britto, L.R., Turck, C.W., Martins-de-Souza, D., 2017. Peptidomic analysis of the anterior temporal lobe and corpus callosum from schizophrenia patients. J Proteomics 151, 97–105. doi.org/10.1016/j.jprot.2016.05.025

Calvo, P.L., Tandoi, F., Haak, T.B., Brunati, A., Pinon, M., Olio, D.D., Romagnoli, R., Spada, M., 2017. NBAS mutations cause acute liver failure: when acetaminophen is not a culprit. Ital J Pediatr 43, 88. doi.org/10.1186/s13052-017-0406-4

Cantone, M., Santos, G., Wentker, P., Lai, X., Vera, J., 2017. Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection. Front Physiol 8, 645. doi.org/10.3389/fphys.2017.00645

Cao, H., Chen, J., Meyer-Lindenberg, A., Schwarz, E., 2017. A polygenic score for schizophrenia predicts glycemic control. Transl Psychiatry 7, 1295. doi.org/10.1038/s41398-017-0044-z

Carecchio, M., Picillo, M., Valletta, L., Elia, A.E., Haack, T.B., Cozzolino, A., Vitale, A., Garavaglia, B., Iuso, A., Bagella, C.F., Pappatà, S., Barone, P., Prokisch, H., Romito, L., Tiranti, V., 2017. Rare causes of early-onset dystonia-parkinsonism with cognitive impairment: a de novo PSEN-1 mutation. Neurogenetics 18, 175–178. doi.org/10.1007/s10048-017-0518-4

Carrillo-Roa, T., Labermaier, C., Weber, P., Herzog, D.P., Lareau, C., Santarelli, S., Wagner, K.V., Rex-Haffner, M., Harbich, D., Scharf, S.H., Nemeroff, C.B., Dunlop, B.W., Craighead, W.E., Mayberg, H.S., Schmidt, M.V., Uhr, M., Holsboer, F., Sillaber, I., Binder, E.B., Müller, M.B., 2017. Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity. PLoS Biol. 15, e2002690. doi.org/10.1371/journal.pbio.2002690

Cavallari, J.F., Fullerton, M.D., Duggan, B.M., Foley, K.P., Denou, E., Smith, B.K., Desjardins, E.M., Henriksbo, B.D., Kim, K.J., Tuinema, B.R., Stearns, J.C., Prescott, D., Rosenstiel, P., Coombes, B.K., Steinberg, G.R., Schertzer, J.D., 2017. Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. Cell Metab. 25, 1063–1074.e3. doi.org/10.1016/j.cmet.2017.03.021

Chan, M.K., Cooper, J.D., Heilmann-Heimbach, S., Frank, J., Witt, S.H., Nöthen, M.M., Steiner, J., Rietschel, M., Bahn, S., 2017. Associations between SNPs and immune-related circulating proteins in schizophrenia. Sci Rep 7, 12586. doi.org/10.1038/s41598-017-12986-0

Chang, H., Li, L., Peng, T., Grigoroiu-Serbanescu, M., Bergen, S.E., Landén, M., Hultman, C.M., Forstner, A.J., Strohmaier, J., Hecker, J., Schulze, T.G., Müller-Myhsok, B., Reif, A., Mitchell, P.B., Martin, N.G., Cichon, S., Nöthen, M.M., Jamain, S., Leboyer, M., Bellivier, F., Etain, B., Kahn, J.-P., Henry, C., Rietschel, M., Swedish Bipolar Study Group, MooDS Consortium, Xiao, X., Li, M., 2017. Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1. Mol. Neurobiol. 54, 5166–5176. doi.org/10.1007/s12035-016-0041-x

Charlet, K., Heinz, A., 2017. Harm reduction-a systematic review on effects of alcohol reduction on physical and mental symptoms. Addict Biol 22, 1119–1159. doi.org/10.1111/adb.12414

Cho, Y.-L., Flossdorf, M., Kretschmer, L., Höfer, T., Busch, D.H., Buchholz, V.R., 2017. TCR Signal Quality Modulates Fate Decisions of Single CD4(+) T Cells in a Probabilistic Manner. Cell Rep 20, 806–818. doi.org/10.1016/j.celrep.2017.07.005

Claussen, J.C., Skiecevičienė, J., Wang, J., Rausch, P., Karlsen, T.H., Lieb, W., Baines, J.F., Franke, A., Hütt, M.-T., 2017. Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome. PLoS Comput. Biol. 13, e1005361. doi.org/10.1371/journal.pcbi.1005361

da Silva Filho, M.I., Försti, A., Weinhold, N., Meziane, I., Campo, C., Huhn, S., Nickel, J., Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Landi, S., Mitchell, J.S., Johnson, D., Morgan, G.J., Houlston, R., Goldschmidt, H., Jauch, A., Milani, P., Merlini, G., Rowcieno, D., Hawkins, P., Hegenbart, U., Palladini, G., Wechalekar, A., Schönland, S.O., Hemminki, K., 2017. Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma. Leukemia 31, 1735–1742. doi.org/10.1038/leu.2016.387

Dand, N., Mucha, S., Tsoi, L.C., Mahil, S.K., Stuart, P.E., Arnold, A., Baurecht, H., Burden, A.D., Callis Duffin, K., Chandran, V., Curtis, C.J., Das, S., Ellinghaus, D., Ellinghaus, E., Enerback, C., Esko, T., Gladman, D.D., Griffiths, C.E.M., Gudjonsson, J.E., Hoffman, P., Homuth, G., Hüffmeier, U., Krueger, G.G., Laudes, M., Lee, S.H., Lieb, W., Lim, H.W., Löhr, S., Mrowietz, U., Müller-Nurayid, M., Nöthen, M., Peters, A., Rahman, P., Reis, A., Reynolds, N.J., Rodriguez, E., Schmidt, C.O., Spain, S.L., Strauch, K., Tejasvi, T., Voorhees, J.J., Warren, R.B., Weichenthal, M., Weidinger, S., Zawistowski, M., Nair, R.P., Capon, F., Smith, C.H., Trembath, R.C., Abecasis, G.R., Elder, J.T., Franke, A., Simpson, M.A., Barker, J.N., 2017. Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling. Hum. Mol. Genet. 26, 4301–4313. doi.org/10.1093/hmg/ddx328

De Landtsheer, S., Trairatphisan, P., Lucarelli, P., Sauter, T., 2017. FALCON: a toolbox for the fast contextualization of logical networks. Bioinformatics 33, 3431–3436. doi.org/10.1093/bioinformatics/btx380

de Sena Cortabitarte, A., Degenhardt, F., Strohmaier, J., Lang, M., Weiss, B., Roeth, R., Giegling, I., Heilmann-Heimbach, S., Hofmann, A., Rujescu, D., Fischer, C., Rietschel, M., Nöthen, M.M., Rappold, G.A., Berkel, S., 2017. Investigation of SHANK3 in schizophrenia. Am. J. Med. Genet. n/a-n/a. doi.org/10.1002/ajmg.b.32528

De Veirman, K., De Beule, N., Maes, K., Menu, E., De Bruyne, E., De Raeve, H., Fostier, K., Moreaux, J., Kassambara, A., Hose, D., Heusschen, R., Eriksson, H., Vanderkerken, K., Van Valckenborgh, E., 2017. Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion. Cancer Immunol Res 5, 839–846. doi.org/10.1158/2326-6066.CIR-17-0192

Degenhardt, F., Seifert, S., Szymczak, S., 2017. Evaluation of variable selection methods for random forests and omics data sets. Brief. Bioinformatics. doi.org/10.1093/bib/bbx124

Deussing, J.M., Jakovcevski, M., 2017. Histone Modifications in Major Depressive Disorder and Related Rodent Models. Adv. Exp. Med. Biol. 978, 169–183. doi.org/10.1007/978-3-319-53889-1_9

Dewi, D.L., Mohapatra, S.R., Cabañes, S.B., Adam, I., Patterson, L.F.S., Berdel, B., Kahloon, M., Thürmann, L., Loth, S., Heilmann, K., Weichenhan, D., Mücke, O., Heiland, I., Wimberger, P., Kuhlmann, J.D., Kellner, K.-H., Schott, S., Plass, C., Platten, M., Gerhäuser, C., Trump, S., Opitz, C.A., 2017. Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. OncoImmunology 0, 00–00. doi.org/10.1080/2162402X.2016.1274477

Doerr, F., George, J., Schmitt, A., Beleggia, F., Rehkämper, T., Hermann, S., Walter, V., Weber, J.-P., Thomas, R.K., Wittersheim, M., Büttner, R., Persigehl, T., Reinhardt, H.C., 2017. Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer. Sci Rep 7, 15511. doi.org/10.1038/s41598-017-15840-5

Doerr, J., Schwarz, M.K., Wiedermann, D., Leinhaas, A., Jakobs, A., Schloen, F., Schwarz, I., Diedenhofen, M., Braun, N.C., Koch, P., Peterson, D.A., Kubitscheck, U., Hoehn, M., Brüstle, O., 2017. Whole-brain 3D mapping of human neural transplant innervation. Nat Commun 8, 14162. doi.org/10.1038/ncomms14162

Du Bois, I., Marsico, A., Bertrams, W., Schweiger, M.R., Caffrey, B.E., Sittka-Stark, A., Eberhardt, M., Vera, J., Vingron, M., Schmeck, B.T., 2016. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J. Infect. Dis. 214, 454–463. doi.org/10.1093/infdis/jiw171

Durstewitz, D., 2017. A state space approach for piecewise-linear recurrent neural networks for identifying computational dynamics from neural measurements. PLoS Comput. Biol. 13, e1005542. doi.org/10.1371/journal.pcbi.1005542

Eberle, J.P., Muranyi, W., Erfle, H., Gunkel, M., 2017. Fully Automated Targeted Confocal and Single-Molecule Localization Microscopy. Methods Mol. Biol. 1663, 139–152. doi.org/10.1007/978-1-4939-7265-4_12

Ellinghaus, E., Ellinghaus, D., Krusche, P., Greiner, A., Schreiber, C., Nikolaus, S., Gieger, C., Strauch, K., Lieb, W., Rosenstiel, P., Frings, N., Fiebig, A., Schreiber, S., Franke, A., 2017. Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci. Sci Rep 7, 45652. doi.org/10.1038/srep45652

Emmadi, M., Khan, N., Lykke, L., Reppe, K., G Parameswarappa, S., Lisboa, M.P., Wienhold, S.-M., Witzenrath, M., Pereira, C.L., Seeberger, P.H., 2017. A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease. J. Am. Chem. Soc. 139, 14783–14791. doi.org/10.1021/jacs.7b07836

Engel, J., Smith, S., Lategahn, J., Tumbrink, H.L., Goebel, L., Becker, C., Hennes, E., Keul, M., Unger, A., Müller, H., Baumann, M., Schultz-Fademrecht, C., Günther, G., Hengstler, J.G., Rauh, D., 2017. Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor. J. Med. Chem. 60, 7725–7744. doi.org/10.1021/acs.jmedchem.7b00515

Erk, S., Mohnke, S., Ripke, S., Lett, T.A., Veer, I.M., Wackerhagen, C., Grimm, O., Romanczuk-Seiferth, N., Degenhardt, F., Tost, H., Mattheisen, M., Mühleisen, T.W., Charlet, K., Skarabis, N., Kiefer, F., Cichon, S., Witt, S.H., Nöthen, M.M., Rietschel, M., Heinz, A., Meyer-Lindenberg, A., Walter, H., 2017. Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains. Transl Psychiatry 7, e997. doi.org/10.1038/tp.2016.272

Falkai, P., Malchow, B., Schmitt, A., 2017. Aerobic exercise and its effects on cognition in schizophrenia. Curr Opin Psychiatry 30, 171–175. doi.org/10.1097/YCO.0000000000000326

Fangmann, D., Theismann, E.-M., Türk, K., Schulte, D.M., Relling, I., Hartmann, K., Keppler, J.K., Knipp, J.-R., Rehman, A., Heinsen, F.-A., Franke, A., Lenk, L., Freitag-Wolf, S., Appel, E., Gorb, S., Brenner, C., Seegert, D., Waetzig, G.H., Rosenstiel, P., Schreiber, S., Schwarz, K., Laudes, M., 2017. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans. Diabetes Care. doi.org/10.2337/dc17-1967

Fichter, C.D., Przypadlo, C.M., Buck, A., Herbener, N., Riedel, B., Schäfer, L., Nakagawa, H., Walch, A., Reinheckel, T., Werner, M., Lassmann, S., 2017. A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion. J. Pathol. 243, 481–495. doi.org/10.1002/path.4987

Flachsbart, F., Dose, J., Gentschew, L., Geismann, C., Caliebe, A., Knecht, C., Nygaard, M., Badarinarayan, N., ElSharawy, A., May, S., Luzius, A., Torres, G.G., Jentzsch, M., Forster, M., Häesler, R., Pallauf, K., Lieb, W., Derbois, C., Galan, P., Drichel, D., Arlt, A., Till, A., Krause-Kyora, B., Rimbach, G., Blanché, H., Deleuze, J.-F., Christiansen, L., Christensen, K., Nothnagel, M., Rosenstiel, P., Schreiber, S., Franke, A., Sebens, S., Nebel, A., 2017. Identification and characterization of two functional variants in the human longevity gene FOXO3. Nat Commun 8, 2063. doi.org/10.1038/s41467-017-02183-y

Foo, J.C., Noori, H.R., Yamaguchi, I., Vengeliene, V., Cosa-Linan, A., Nakamura, T., Morita, K., Spanagel, R., Yamamoto, Y., 2017. Dynamical state transitions into addictive behaviour and their early-warning signals. Proc. Biol. Sci. 284. doi.org/10.1098/rspb.2017.0882

Forstner, A.J., Hecker, J., Hofmann, A., Maaser, A., Reinbold, C.S., Mühleisen, T.W., Leber, M., Strohmaier, J., Degenhardt, F., Treutlein, J., Mattheisen, M., Schumacher, J., Streit, F., Meier, S., Herms, S., Hoffmann, P., Lacour, A., Witt, S.H., Reif, A., Müller-Myhsok, B., Lucae, S., Maier, W., Schwarz, M., Vedder, H., Kammerer-Ciernioch, J., Pfennig, A., Bauer, M., Hautzinger, M., Moebus, S., Schenk, L.M., Fischer, S.B., Sivalingam, S., Czerski, P.M., Hauser, J., Lissowska, J., Szeszenia-Dabrowska, N., Brennan, P., McKay, J.D., Wright, A., Mitchell, P.B., Fullerton, J.M., Schofield, P.R., Montgomery, G.W., Medland, S.E., Gordon, S.D., Martin, N.G., Krasnov, V., Chuchalin, A., Babadjanova, G., Pantelejeva, G., Abramova, L.I., Tiganov, A.S., Polonikov, A., Khusnutdinova, E., Alda, M., Cruceanu, C., Rouleau, G.A., Turecki, G., Laprise, C., Rivas, F., Mayoral, F., Kogevinas, M., Grigoroiu-Serbanescu, M., Becker, T., Schulze, T.G., Rietschel, M., Cichon, S., Fier, H., Nöthen, M.M., 2017a. Identification of shared risk loci and pathways for bipolar disorder and schizophrenia. PLOS ONE 12, e0171595. doi.org/10.1371/journal.pone.0171595

Forstner, A.J., Rambau, S., Friedrich, N., Ludwig, K.U., Böhmer, A.C., Mangold, E., Maaser, A., Hess, T., Kleiman, A., Bittner, A., Nöthen, M.M., Becker, J., Geiser, F., Schumacher, J., Conrad, R., 2017b. Further evidence for genetic variation at the serotonin transporter gene SLC6A4 contributing toward anxiety. Psychiatr. Genet. 27, 96–102. doi.org/10.1097/YPG.0000000000000171

Frischknecht, U., Hermann, D., Tunc-Skarka, N., Wang, G.-Y., Sack, M., van Eijk, J., Demirakca, T., Falfan-Melgoza, C., Krumm, B., Dieter, S., Spanagel, R., Kiefer, F., Mann, K.F., Sommer, W.H., Ende, G., Weber-Fahr, W., 2017. Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats. Alcohol. Clin. Exp. Res. 41, 323–333. doi.org/10.1111/acer.13308

Fritze, S., Spanagel, R., Noori, H.R., 2017. Adaptive dynamics of the 5-HT systems following chronic administration of selective serotonin reuptake inhibitors: a meta-analysis. J. Neurochem. 142, 747–755. doi.org/10.1111/jnc.14114

Fröhlich, F., Kaltenbacher, B., Theis, F.J., Hasenauer, J., 2017a. Scalable Parameter Estimation for Genome-Scale Biochemical Reaction Networks. PLoS Comput. Biol. 13, e1005331. doi.org/10.1371/journal.pcbi.1005331

Fröhlich, F., Theis, F.J., Rädler, J.O., Hasenauer, J., 2017b. Parameter estimation for dynamical systems with discrete events and logical operations. Bioinformatics 33, 1049–1056. doi.org/10.1093/bioinformatics/btw764

Gámez-Díaz, L., Neumann, J., Jäger, F., Proietti, M., Felber, F., Soulas-Sprauel, P., Perruzza, L., Grassi, F., Kögl, T., Aichele, P., Kilimann, M., Grimbacher, B., Jung, S., 2017. Immunological phenotype of the murine Lrba knockout. Immunol. Cell Biol. 95, 789–802. doi.org/10.1038/icb.2017.52

Garrett, L., Becker, L., Rozman, J., Puk, O., Stoeger, T., Yildirim, A.Ö., Bohla, A., Eickelberg, O., Hans, W., Prehn, C., Adamski, J., Klopstock, T., Rácz, I., Zimmer, A., Klingenspor, M., Fuchs, H., Gailus-Durner, V., Wurst, W., Hrabě de Angelis, M., Graw, J., Hölter, S.M., 2017. Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice. Mol. Neurobiol. doi.org/10.1007/s12035-017-0659-3

Gärtner, M., Duvarci, S., Roeper, J., Schneider, G., 2017. Detecting joint pausiness in parallel spike trains. J. Neurosci. Methods 285, 69–81. doi.org/10.1016/j.jneumeth.2017.05.008

George, J., Saito, M., Tsuta, K., Iwakawa, R., Shiraishi, K., Scheel, A.H., Uchida, S., Watanabe, S.-I., Nishikawa, R., Noguchi, M., Peifer, M., Jang, S.J., Petersen, I., Büttner, R., Harris, C.C., Yokota, J., Thomas, R.K., Kohno, T., 2017. Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin. Cancer Res. 23, 1220–1226. doi.org/10.1158/1078-0432.CCR-16-1069

Giesert, F., Glasl, L., Zimprich, A., Ernst, L., Piccoli, G., Stautner, C., Zerle, J., Hölter, S.M., Vogt Weisenhorn, D.M., Wurst, W., 2017. The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson’s disease in the mouse. Neurobiol. Dis. 105, 179–193. doi.org/10.1016/j.nbd.2017.05.013

Gispert, J.D., Figueiras, F.P., Vengeliene, V., Herance, J.R., Rojas, S., Spanagel, R., 2017. Changes in cerebral [(18)F]-FDG uptake induced by acute alcohol administration in a rat model of alcoholism. Behav. Brain Res. 327, 29–33. doi.org/10.1016/j.bbr.2017.03.038

Glasgow, R.I.C., Thompson, K., Barbosa, I.A., He, L., Alston, C.L., Deshpande, C., Simpson, M.A., Morris, A.A.M., Neu, A., Löbel, U., Hall, J., Prokisch, H., Haack, T.B., Hempel, M., McFarland, R., Taylor, R.W., 2017. Novel GFM2 variants associated with early-onset neurological presentations of mitochondrial disease and impaired expression of OXPHOS subunits. Neurogenetics 18, 227–235. doi.org/10.1007/s10048-017-0526-4

Golan-Lavi, R., Giacomelli, C., Fuks, G., Zeisel, A., Sonntag, J., Sinha, S., Köstler, W., Wiemann, S., Korf, U., Yarden, Y., Domany, E., 2017. Coordinated Pulses of mRNA and of Protein Translation or Degradation Produce EGF-Induced Protein Bursts. Cell Rep 18, 3129–3142. doi.org/10.1016/j.celrep.2017.03.014

Graf, M., Bonetti, D., Lockhart, A., Serhal, K., Kellner, V., Maicher, A., Jolivet, P., Teixeira, M.T., Luke, B., 2017. Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle. Cell 170, 72–85.e14. doi.org/10.1016/j.cell.2017.06.006

Granzow, M., Hegenbart, U., Hinderhofer, K., Hose, D., Seckinger, A., Bochtler, T., Hemminki, K., Goldschmidt, H., Schönland, S.O., Jauch, A., 2017. Novel recurrent chromosomal aberrations detected in clonal plasma cells of light chain amyloidosis patients show potential adverse prognostic effect: first results from a genome-wide copy number array analysis. Haematologica 102, 1281–1290. doi.org/10.3324/haematol.2016.160721

Guggenmos, M., Schmack, K., Sekutowicz, M., Garbusow, M., Sebold, M., Sommer, C., Smolka, M.N., Wittchen, H.-U., Zimmermann, U.S., Heinz, A., Sterzer, P., 2017. Quantitative neurobiological evidence for accelerated brain aging in alcohol dependence. Transl Psychiatry 7, 1279. doi.org/10.1038/s41398-017-0037-y

Gunes, C., Avila, A.I., Rudolph, K.L., 2017. Telomeres in cancer. Differentiation 99, 41–50. doi.org/10.1016/j.diff.2017.12.004

Gunkel, M., Chung, I., Wörz, S., Deeg, K.I., Simon, R., Sauter, G., Jones, D.T.W., Korshunov, A., Rohr, K., Erfle, H., Rippe, K., 2017a. Quantification of telomere features in tumor tissue sections by an automated 3D imaging-based workflow. Methods 114, 60–73. doi.org/10.1016/j.ymeth.2016.09.014

Gunkel, M., Eberle, J.P., Erfle, H., 2017b. Fluorescence-Based High-Throughput and Targeted Image Acquisition and Analysis for Phenotypic Screening. Methods Mol. Biol. 1563, 269–280. doi.org/10.1007/978-1-4939-6810-7_17

Guo, Y., Baumgart, S., Stärk, H.-J., Harms, H., Müller, S., 2017. Mass Cytometry for Detection of Silver at the Bacterial Single Cell Level. Front Microbiol 8, 1326. doi.org/10.3389/fmicb.2017.01326

Gutbier, B., Jiang, X., Dietert, K., Ehrler, C., Lienau, J., Van Slyke, P., Kim, H., Hoang, V.C., Maynes, J.T., Dumont, D.J., Gruber, A.D., Weissmann, N., Mitchell, T.J., Suttorp, N., Witzenrath, M., 2017. Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia. Crit Care 21, 274. doi.org/10.1186/s13054-017-1851-6

Habarou, F., Hamel, Y., Haack, T.B., Feichtinger, R.G., Lebigot, E., Marquardt, I., Busiah, K., Laroche, C., Madrange, M., Grisel, C., Pontoizeau, C., Eisermann, M., Boutron, A., Chrétien, D., Chadefaux-Vekemans, B., Barouki, R., Bole-Feysot, C., Nitschke, P., Goudin, N., Boddaert, N., Nemazanyy, I., Delahodde, A., Kölker, S., Rodenburg, R.J., Korenke, G.C., Meitinger, T., Strom, T.M., Prokisch, H., Rotig, A., Ottolenghi, C., Mayr, J.A., Lonlay, P. de, 2017. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. The American Journal of Human Genetics 0. doi.org/10.1016/j.ajhg.2017.07.001

Hadar, R., Voget, M., Vengeliene, V., Haumesser, J.K., van Riesen, C., Avchalumov, Y., Spanagel, R., Winter, C., 2017. Altered neural oscillations and elevated dopamine levels in the reward pathway during alcohol relapse. Behav. Brain Res. 316, 131–135. doi.org/10.1016/j.bbr.2016.08.045

Hatzikirou, H., López Alfonso, J.C., Leschner, S., Weiss, S., Meyer-Hermann, M., 2017. Therapeutic Potential of Bacteria against Solid Tumors. Cancer Res. 77, 1553–1563. doi.org/10.1158/0008-5472.CAN-16-1621

Heinig, M., Adriaens, M.E., Schafer, S., van Deutekom, H.W.M., Lodder, E.M., Ware, J.S., Schneider, V., Felkin, L.E., Creemers, E.E., Meder, B., Katus, H.A., Rühle, F., Stoll, M., Cambien, F., Villard, E., Charron, P., Varro, A., Bishopric, N.H., George, A.L., Dos Remedios, C., Moreno-Moral, A., Pesce, F., Bauerfeind, A., Rüschendorf, F., Rintisch, C., Petretto, E., Barton, P.J., Cook, S.A., Pinto, Y.M., Bezzina, C.R., Hubner, N., 2017. Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. Genome Biol. 18, 170. doi.org/10.1186/s13059-017-1286-z

Henssen, A.G., Odersky, A., Szymansky, A., Seiler, M., Althoff, K., Beckers, A., Speleman, F., Schäfers, S., De Preter, K., Astrahanseff, K., Struck, J., Schramm, A., Eggert, A., Bergmann, A., Schulte, J.H., 2017. Targeting tachykinin receptors in neuroblastoma. Oncotarget 8, 430–443. doi.org/10.18632/oncotarget.13440

Herebian, D., Alhaddad, B., Seibt, A., Schwarzmayr, T., Danhauser, K., Klee, D., Harmsen, S., Meitinger, T., Strom, T.M., Schulz, A., Mayatepek, E., Haack, T.B., Distelmaier, F., 2017. Coexisting variants in OSTM1 and MANEAL cause a complex neurodegenerative disorder with NBIA-like brain abnormalities. Eur. J. Hum. Genet. 25, 1092–1095. doi.org/10.1038/ejhg.2017.96

Hermann, D., Hirth, N., Reimold, M., Batra, A., Smolka, M.N., Hoffmann, S., Kiefer, F., Noori, H.R., Sommer, W.H., Reischl, G., la Fougère, C., Mann, K., Spanagel, R., Hansson, A.C., 2017. Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis. Neuropsychopharmacology 42, 606–614. doi.org/10.1038/npp.2016.145

Hermann, H., Runnel, T., Aab, A., Baurecht, H., Rodriguez, E., Magilnick, N., Urgard, E., Šahmatova, L., Prans, E., Maslovskaja, J., Abram, K., Karelson, M., Kaldvee, B., Reemann, P., Haljasorg, U., Rückert, B., Wawrzyniak, P., Weichenthal, M., Mrowietz, U., Franke, A., Gieger, C., Barker, J., Trembath, R., Tsoi, L.C., Elder, J.T., Tkaczyk, E.R., Kisand, K., Peterson, P., Kingo, K., Boldin, M., Weidinger, S., Akdis, C.A., Rebane, A., 2017. miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. J. Invest. Dermatol. 137, 1945–1954. doi.org/10.1016/j.jid.2017.05.012

Herold, S., Kuhn, M., Bonin, M.V., Stange, T., Platzbecker, U., Radke, J., Lange, T., Sockel, K., Gutsche, K., Schetelig, J., Röllig, C., Schuster, C., Roeder, I., Dahl, A., Mohr, B., Serve, H., Brandts, C., Ehninger, G., Bornhäuser, M., Thiede, C., 2017a. Donor cell leukemia-Evidence for multiple pre-leukemic clones and parallel long term clonal evolution in donor and recipient. Leukemia. doi.org/10.1038/leu.2017.104

Herold, S., Sockel, K., Sayehli, C., Herbst, R., Dührsen, U., Oelschlägel, U., Böttner, A., Hindahl, H., Kullmer, J., Helas, S., Sauer, M., Mohr, B., Mies, A., Bornhäuser, M., Ehninger, G., Röllig, C., Thiede, C., Platzbecker, U., 2017b. Evolution of NPM1-negative therapy-related myelodysplastic syndromes following curative treatment of NPM1-mutant AML. Leukemia 31, 2247–2251. doi.org/10.1038/leu.2017.217

Hertel, J., König, J., Homuth, G., Van der Auwera, S., Wittfeld, K., Pietzner, M., Kacprowski, T., Pfeiffer, L., Kretschmer, A., Waldenberger, M., Kastenmüller, G., Artati, A., Suhre, K., Adamski, J., Langner, S., Völker, U., Völzke, H., Nauck, M., Friedrich, N., Grabe, H.J., 2017. Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives. Sci Rep 7, 14111. doi.org/10.1038/s41598-017-13927-7

Hoffmann, A., Sportelli, V., Ziller, M., Spengler, D., 2017. Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides. Int J Mol Sci 18. doi.org/10.3390/ijms18081711

Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C.A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D’Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K.K.-H., Franke, A., Gori, A.-S., Goyette, P., Halfvarson, J., Haritunians, T., Knight, J., Lawrance, I.C., Lees, C.W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S.L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R.J., International Inflammatory Bowel Disease Genetics Consortium, Weersma, R.K., Duerr, R.H., Mathew, C.G., Rioux, J.D., McGovern, D.P.B., Cho, J.H., Georges, M., Daly, M.J., Barrett, J.C., 2017. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature 547, 173–178. doi.org/10.1038/nature22969

Hummel, M., Edelmann, D., Kopp-Schneider, A., 2017. Clustering of samples and variables with mixed-type data. PLoS ONE 12, e0188274. doi.org/10.1371/journal.pone.0188274

Hutt, M., Marquardt, L., Seifert, O., Siegemund, M., Müller, I., Kulms, D., Pfizenmaier, K., Kontermann, R.E., 2017. Superior Properties of Fc-comprising scTRAIL Fusion Proteins. Mol. Cancer Ther. 16, 2792–2802. doi.org/10.1158/1535-7163.MCT-17-0551

Jabs, J., Zickgraf, F.M., Park, J., Wagner, S., Jiang, X., Jechow, K., Kleinheinz, K., Toprak, U.H., Schneider, M.A., Meister, M., Spaich, S., Sütterlin, M., Schlesner, M., Trumpp, A., Sprick, M., Eils, R., Conrad, C., 2017. Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. Mol. Syst. Biol. 13, 955.

Jagiella, N., Rickert, D., Theis, F.J., Hasenauer, J., 2017. Parallelization and High-Performance Computing Enables Automated Statistical Inference of Multi-scale Models. Cell Syst 4, 194–206.e9. doi.org/10.1016/j.cels.2016.12.002

Jägle, S., Busch, H., Freihen, V., Beyes, S., Schrempp, M., Boerries, M., Hecht, A., 2017. SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells. PLoS Genet. 13, e1007109. doi.org/10.1371/journal.pgen.1007109

Jansen, I.E., Gibbs, J.R., Nalls, M.A., Price, T.R., Lubbe, S., van Rooij, J., Uitterlinden, A.G., Kraaij, R., Williams, N.M., Brice, A., Hardy, J., Wood, N.W., Morris, H.R., Gasser, T., Singleton, A.B., Heutink, P., Sharma, M., International Parkinson’s Disease Genomics Consortium, 2017a. Establishing the role of rare coding variants in known Parkinson’s disease risk loci. Neurobiol. Aging 59, 220.e11-220.e18. doi.org/10.1016/j.neurobiolaging.2017.07.009

Jansen, I.E., Ye, H., Heetveld, S., Lechler, M.C., Michels, H., Seinstra, R.I., Lubbe, S.J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J.R., Nalls, M.A., Ryten, M., Botia, J.A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., Chouhan, A.K., Li, Y., Yogi, P., Amin, N., van Duijn, C.M., International Parkinson’s Disease Genetics Consortium (IPGDC), Morris, H.R., Brice, A., Singleton, A.B., David, D.C., Nollen, E.A., Jain, S., Shulman, J.M., Heutink, P., 2017b. Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing. Genome Biol. 18, 22. doi.org/10.1186/s13059-017-1147-9

Jensen, A.V., Faurholt-Jepsen, D., Egelund, G.B., Andersen, S.B., Petersen, P.T., Benfield, T., Witzenrath, M., Rohde, G., Ravn, P., German Community-Acquired Pneumonia Competence Network (CAPNETZ), German Community-Acquired Pneumonia Competence Network (CAPNETZ), 2017. Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study. Clin. Infect. Dis. 65, 2091–2098. doi.org/10.1093/cid/cix703

Jentho, E., Bodden, M., Schulz, C., Jung, A.-L., Seidel, K., Schmeck, B., Bertrams, W., 2017. microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1. PLoS ONE 12, e0176204. doi.org/10.1371/journal.pone.0176204

Ji, S.-G., Juran, B.D., Mucha, S., Folseraas, T., Jostins, L., Melum, E., Kumasaka, N., Atkinson, E.J., Schlicht, E.M., Liu, J.Z., Shah, T., Gutierrez-Achury, J., Boberg, K.M., Bergquist, A., Vermeire, S., Eksteen, B., Durie, P.R., Farkkila, M., Müller, T., Schramm, C., Sterneck, M., Weismüller, T.J., Gotthardt, D.N., Ellinghaus, D., Braun, F., Teufel, A., Laudes, M., Lieb, W., Jacobs, G., Beuers, U., Weersma, R.K., Wijmenga, C., Marschall, H.-U., Milkiewicz, P., Pares, A., Kontula, K., Chazouillères, O., Invernizzi, P., Goode, E., Spiess, K., Moore, C., Sambrook, J., Ouwehand, W.H., Roberts, D.J., Danesh, J., Floreani, A., Gulamhusein, A.F., Eaton, J.E., Schreiber, S., Coltescu, C., Bowlus, C.L., Luketic, V.A., Odin, J.A., Chopra, K.B., Kowdley, K.V., Chalasani, N., Manns, M.P., Srivastava, B., Mells, G., Sandford, R.N., Alexander, G., Gaffney, D.J., Chapman, R.W., Hirschfield, G.M., de Andrade, M., UK-PSC Consortium, International IBD Genetics Consortium, International PSC Study Group, Rushbrook, S.M., Franke, A., Karlsen, T.H., Lazaridis, K.N., Anderson, C.A., 2017. Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nat. Genet. 49, 269–273. doi.org/10.1038/ng.3745

Jung, A.L., Herkt, C.E., Schulz, C., Bolte, K., Seidel, K., Scheller, N., Sittka-Stark, A., Bertrams, W., Schmeck, B., 2017. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep 7, 6301. doi.org/10.1038/s41598-017-06443-1

Jung, A.L., Hoffmann, K., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2017. Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages. J Vis Exp. doi.org/10.3791/55146

Jünger, E., Javadi, A.-H., Wiers, C.E., Sommer, C., Garbusow, M., Bernhardt, N., Kuitunen-Paul, S., Smolka, M.N., Zimmermann, U.S., 2017. Acute alcohol effects on explicit and implicit motivation to drink alcohol in socially drinking adolescents. J. Psychopharmacol. (Oxford) 31, 893–905. doi.org/10.1177/0269881117691454

Jungverdorben, J., Till, A., Brüstle, O., 2017. Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy. J. Mol. Med. 95, 705–718. doi.org/10.1007/s00109-017-1533-5

Kaistha, B.P., Krattenmacher, A., Fredebohm, J., Schmidt, H., Behrens, D., Widder, M., Hackert, T., Strobel, O., Hoheisel, J.D., Gress, T.M., Buchholz, M., Kaistha, B.P., Krattenmacher, A., Fredebohm, J., Schmidt, H., Behrens, D., Widder, M., Hackert, T., Strobel, O., Hoheisel, J.D., Gress, T.M., Buchholz, M., 2017. The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators. Oncotarget 8, 66215–66225. doi.org/10.18632/oncotarget.19882

Kaitsiotou, H., Keul, M., Hardick, J., Mühlenberg, T., Ketzer, J., Ehrt, C., Krüll, J., Medda, F., Koch, O., Giordanetto, F., Bauer, S., Rauh, D., 2017. Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT. J. Med. Chem. 60, 8801–8815. doi.org/10.1021/acs.jmedchem.7b00841

Keller, S., Kneissl, J., Grabher-Meier, V., Heindl, S., Hasenauer, J., Maier, D., Mattes, J., Winter, P., Luber, B., 2017. Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. BMC Cancer 17, 845. doi.org/10.1186/s12885-017-3822-3

Kelm, M., Goubergrits, L., Bruening, J., Yevtushenko, P., Fernandes, J.F., Sündermann, S.H., Berger, F., Falk,  null, Kuehne, T., CARDIOPROOF group, Nordmeyer, S., 2017. Model-Based Therapy Planning Allows Prediction of Haemodynamic Outcome after Aortic Valve Replacement. Sci Rep 7, 9897. doi.org/10.1038/s41598-017-03693-x

Kessler, T., Wobst, J., Wolf, B., Eckhold, J., Vilne, B., Hollstein, R., von Ameln, S., Dang, T.A., Sager, H.B., Moritz Rumpf, P., Aherrahrou, R., Kastrati, A., Björkegren, J.L.M., Erdmann, J., Lusis, A.J., Civelek, M., Kaiser, F.J., Schunkert, H., 2017. Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus. Circulation 136, 476–489. doi.org/10.1161/CIRCULATIONAHA.116.024152

Khailaie, S., Rowshanravan, B., Robert, P.A., Walker, L.S.K., Sansom, D.M., Meyer-Hermann, M., 2017. Quantitative characterization of CTLA4 trafficking and turnover using a combined in vitro and in silico approach. bioRxiv 106898. doi.org/10.1101/106898

Kluth, M., Jung, S., Habib, O., Eshagzaiy, M., Heinl, A., Amschler, N., Masser, S., Mader, M., Runte, F., Barow, P., Frogh, S., Omari, J., Möller-Koop, C., Hube-Magg, C., Weischenfeldt, J., Korbel, J., Steurer, S., Krech, T., Huland, H., Graefen, M., Minner, S., Sauter, G., Schlomm, T., Simon, R., 2017. Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer. Oncotarget 8, 108923–108935. doi.org/10.18632/oncotarget.22408

Knecht, C., Mort, M., Junge, O., Cooper, D.N., Krawczak, M., Caliebe, A., 2017. IMHOTEP-a composite score integrating popular tools for predicting the functional consequences of non-synonymous sequence variants. Nucleic Acids Res. 45, e13. doi.org/10.1093/nar/gkw886

Kneissl, J., Hartmann, A., Pfarr, N., Erlmeier, F., Lorber, T., Keller, S., Zwingenberger, G., Weichert, W., Luber, B., 2017. Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines. J. Cancer Res. Clin. Oncol. 143, 573–600. doi.org/10.1007/s00432-016-2308-z

Knittel, G., Rehkämper, T., Korovkina, D., Liedgens, P., Fritz, C., Torgovnick, A., Al-Baldawi, Y., Al-Maarri, M., Cun, Y., Fedorchenko, O., Riabinska, A., Beleggia, F., Nguyen, P.-H., Wunderlich, F.T., Ortmann, M., Montesinos-Rongen, M., Tausch, E., Stilgenbauer, S., P Frenzel, L., Herling, M., Herling, C., Bahlo, J., Hallek, M., Peifer, M., Buettner, R., Persigehl, T., Reinhardt, H.C., 2017. Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia. Nat Commun 8, 153. doi.org/10.1038/s41467-017-00210-6

Knüppel, R., Christensen, R.H., Gray, F.C., Esser, D., Strauß, D., Medenbach, J., Siebers, B., MacNeill, S.A., LaRonde, N., Ferreira-Cerca, S., 2017. Insights into the evolutionary conserved regulation of Rio ATPase activity. Nucleic Acids Res. doi.org/10.1093/nar/gkx1236

Ko, D., Rahman, F., Martins, M.A.P., Hylek, E.M., Ellinor, P.T., Schnabel, R.B., Benjamin, E.J., Christophersen, I.E., 2017. Atrial fibrillation in women: treatment. Nat Rev Cardiol 14, 113–124. doi.org/10.1038/nrcardio.2016.171

Koch, J., Mayr, J.A., Alhaddad, B., Rauscher, C., Bierau, J., Kovacs-Nagy, R., Coene, K.L.M., Bader, I., Holzhacker, M., Prokisch, H., Venselaar, H., Wevers, R.A., Distelmaier, F., Polster, T., Leiz, S., Betzler, C., Strom, T.M., Sperl, W., Meitinger, T., Wortmann, S.B., Haack, T.B., 2017. CAD mutations and uridine-responsive epileptic encephalopathy. Brain 140, 279–286. doi.org/10.1093/brain/aww300

Koch, M., Freitag-Wolf, S., Schlesinger, S., Borggrefe, J., Hov, J.R., Jensen, M.K., Pick, J., Markus, M.R.P., Höpfner, T., Jacobs, G., Siegert, S., Artati, A., Kastenmüller, G., Römisch-Margl, W., Adamski, J., Illig, T., Nothnagel, M., Karlsen, T.H., Schreiber, S., Franke, A., Krawczak, M., Nöthlings, U., Lieb, W., 2017. Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. Eur J Clin Nutr 71, 995–1001. doi.org/10.1038/ejcn.2017.43

Konte, B., Leicht, G., Giegling, I., Pogarell, O., Karch, S., Hartmann, A.M., Friedl, M., Hegerl, U., Rujescu, D., Mulert, C., 2017. A genome-wide association study of early gamma-band response in a schizophrenia case-control sample. World J. Biol. Psychiatry 1–8. doi.org/10.1080/15622975.2017.1366054

Koopmann, A., Lippmann, K., Schuster, R., Reinhard, I., Bach, P., Weil, G., Rietschel, M., Witt, S.H., Wiedemann, K., Kiefer, F., 2017. Drinking water to reduce alcohol craving? A randomized controlled study on the impact of ghrelin in mediating the effects of forced water intake in alcohol addiction. Psychoneuroendocrinology 85, 56–62. doi.org/10.1016/j.psyneuen.2017.08.005

Kopczynski, D., Coman, C., Zahedi, R.P., Lorenz, K., Sickmann, A., Ahrends, R., 2017. Multi-OMICS: a critical technical perspective on integrative lipidomics approaches. Biochim. Biophys. Acta 1862, 808–811. doi.org/10.1016/j.bbalip.2017.02.003

Koppe, G., Mallien, A.S., Berger, S., Bartsch, D., Gass, P., Vollmayr, B., Durstewitz, D., 2017. CACNA1C gene regulates behavioral strategies in operant rule learning. PLoS Biol. 15, e2000936. doi.org/10.1371/journal.pbio.2000936

Korshunov, A., Schrimpf, D., Ryzhova, M., Sturm, D., Chavez, L., Hovestadt, V., Sharma, T., Habel, A., Burford, A., Jones, C., Zheludkova, O., Kumirova, E., Kramm, C.M., Golanov, A., Capper, D., von Deimling, A., Pfister, S.M., Jones, D.T.W., 2017. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers. Acta Neuropathol. 134, 507–516. doi.org/10.1007/s00401-017-1710-1

Kossack, M., Hein, S., Juergensen, L., Siragusa, M., Benz, A., Katus, H.A., Most, P., Hassel, D., 2017. Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. J. Mol. Cell. Cardiol. 108, 95–105. doi.org/10.1016/j.yjmcc.2017.05.011

Kraus, M., Niedermeier, J., Jankrift, M., Tietboehl, S., Stachewicz, T., Folkerts, H., Uflacker, M., Neves, M., 2017. Olelo: a web application for intuitive exploration of biomedical literature. Nucleic Acids Res. 45, W478–W483. doi.org/10.1093/nar/gkx363

Kremer, L.S., Bader, D.M., Mertes, C., Kopajtich, R., Pichler, G., Iuso, A., Haack, T.B., Graf, E., Schwarzmayr, T., Terrile, C., Koňaříková, E., Repp, B., Kastenmüller, G., Adamski, J., Lichtner, P., Leonhardt, C., Funalot, B., Donati, A., Tiranti, V., Lombes, A., Jardel, C., Gläser, D., Taylor, R.W., Ghezzi, D., Mayr, J.A., Rötig, A., Freisinger, P., Distelmaier, F., Strom, T.M., Meitinger, T., Gagneur, J., Prokisch, H., 2017. Genetic diagnosis of Mendelian disorders via RNA sequencing. Nat Commun 8, 15824. doi.org/10.1038/ncomms15824

Kuhlmann, L., Nadler, W.M., Kerner, A., Hanke, S.A., Noll, E.M., Eisen, C., Espinet, E., Vogel, V., Trumpp, A., Sprick, M.R., Roesli, C.P., 2017. Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma. Pancreas 46, 311–322. doi.org/10.1097/MPA.0000000000000743

Kunzke, T., Balluff, B., Feuchtinger, A., Buck, A., Langer, R., Luber, B., Lordick, F., Zitzelsberger, H., Aichler, M., Walch, A., Kunzke, T., Balluff, B., Feuchtinger, A., Buck, A., Langer, R., Luber, B., Lordick, F., Zitzelsberger, H., Aichler, M., Walch, A., 2017. Native glycan fragments detected by MALDI-FT-ICR mass spectrometry imaging impact gastric cancer biology and patient outcome. Oncotarget 8, 68012–68025. doi.org/10.18632/oncotarget.19137

Kurucay, M., Kloth, C., Kaufmann, S., Nikolaou, K., Bösmüller, H., Horger, M., Thaiss, W.M., 2017. Multiparametric imaging for detection and characterization of hepatocellular carcinoma using gadoxetic acid-enhanced MRI and perfusion-CT: which parameters work best? Cancer Imaging 17, 18. doi.org/10.1186/s40644-017-0121-9

Lafuente-Barquero, J., Luke-Glaser, S., Graf, M., Silva, S., Gómez-González, B., Lockhart, A., Lisby, M., Aguilera, A., Luke, B., 2017b. The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. PLoS Genet. 13, e1007136. doi.org/10.1371/journal.pgen.1007136

Lang, S., Busch, H., Boerries, M., Brummer, T., Timme, S., Lassmann, S., Aktories, K., Schmidt, G., 2017. Specific role of RhoC in tumor invasion and metastasis. Oncotarget 8, 87364–87378. doi.org/10.18632/oncotarget.20957

Lausser, L., Szekely, R., Schirra, L.-R., Kestler, H.A., 2017. The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes. Neural Process Lett 1–18. doi.org/10.1007/s11063-017-9706-3

Law, P.J., Sud, A., Mitchell, J.S., Henrion, M., Orlando, G., Lenive, O., Broderick, P., Speedy, H.E., Johnson, D.C., Kaiser, M., Weinhold, N., Cooke, R., Sunter, N.J., Jackson, G.H., Summerfield, G., Harris, R.J., Pettitt, A.R., Allsup, D.J., Carmichael, J., Bailey, J.R., Pratt, G., Rahman, T., Pepper, C., Fegan, C., von Strandmann, E.P., Engert, A., Försti, A., Chen, B., Filho, M.I. da S., Thomsen, H., Hoffmann, P., Noethen, M.M., Eisele, L., Jöckel, K.-H., Allan, J.M., Swerdlow, A.J., Goldschmidt, H., Catovsky, D., Morgan, G.J., Hemminki, K., Houlston, R.S., 2017. Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci. Sci Rep 7, 41071. doi.org/10.1038/srep41071

Lehners, N., Becker, N., Benner, A., Pritsch, M., Löpprich, M., Mai, E.K., Hillengass, J., Goldschmidt, H., Raab, M.-S., 2017. Analysis of long-term survival in multiple myeloma after first-line autologous stem cell transplantation: impact of clinical risk factors and sustained response. Cancer Med. doi.org/10.1002/cam4.1283

Lett, T.A., Waller, L., Tost, H., Veer, I.M., Nazeri, A., Erk, S., Brandl, E.J., Charlet, K., Beck, A., Vollstädt-Klein, S., Jorde, A., Kiefer, F., Heinz, A., Meyer-Lindenberg, A., Chakravarty, M.M., Walter, H., 2017. Cortical surface-based threshold-free cluster enhancement and cortexwise mediation. Hum Brain Mapp 38, 2795–2807. doi.org/10.1002/hbm.23563

Li, N., Johnson, D.C., Weinhold, N., Kimber, S., Dobbins, S.E., Mitchell, J.S., Kinnersley, B., Sud, A., Law, P.J., Orlando, G., Scales, M., Wardell, C.P., Försti, A., Hoang, P.H., Went, M., Holroyd, A., Hariri, F., Pastinen, T., Meissner, T., Goldschmidt, H., Hemminki, K., Morgan, G.J., Kaiser, M., Houlston, R.S., 2017. Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism. Cell Rep 20, 2556–2564. doi.org/10.1016/j.celrep.2017.08.062

Lim, S.-Y., Macheleidt, I., Dalvi, P., Schäfer, S.C., Kerick, M., Ozretić, L., Ortiz-Cuaran, S., George, J., Merkelbach-Bruse, S., Wolf, J., Timmermann, B., Thomas, R.K., Schweiger, M.R., Buettner, R., Odenthal, M., 2017. LSD1 modulates the non-canonical integrin β3 signaling pathway in non-small cell lung carcinoma cells. Sci Rep 7, 10292. doi.org/10.1038/s41598-017-09554-x

Linke, F., Harenberg, M., Nietert, M.M., Zaunig, S., von Bonin, F., Arlt, A., Szczepanowski, M., Weich, H.A., Lutz, S., Dullin, C., Janovská, P., Krafčíková, M., Trantírek, L., Ovesná, P., Klapper, W., Beissbarth, T., Alves, F., Bryja, V., Trümper, L., Wilting, J., Kube, D., 2017. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia 31, 361–372. doi.org/10.1038/leu.2016.232

Lisboa, M.P., Khan, N., Martin, C., Xu, F.-F., Reppe, K., Geissner, A., Govindan, S., Witzenrath, M., Pereira, C.L., Seeberger, P.H., 2017. Semisynthetic glycoconjugate vaccine candidate againstStreptococcus pneumoniaeserotype 5. Proc. Natl. Acad. Sci. U.S.A. 114, 11063–11068. doi.org/10.1073/pnas.1706875114

Lubitz, S.A., Parsons, O.E., Anderson, C.D., Benjamin, E.J., Malik, R., Weng, L.-C., Dichgans, M., Sudlow, C.L., Rothwell, P.M., Rosand, J., Ellinor, P.T., Markus, H.S., Traylor, M., WTCCC2, International Stroke Genetics Consortium, and AFGen Consortia, 2017. Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms. Stroke 48, 1451–1456. doi.org/10.1161/STROKEAHA.116.016198

Luedde, M., Winkler, T., Heinsen, F.-A., Rühlemann, M.C., Spehlmann, M.E., Bajrovic, A., Lieb, W., Franke, A., Ott, S.J., Frey, N., 2017. Heart failure is associated with depletion of core intestinal microbiota. ESC Heart Fail 4, 282–290. doi.org/10.1002/ehf2.12155

Mackey, S., Chaarani, B., Kan, K.-J., Spechler, P.A., Orr, C., Banaschewski, T., Barker, G., Bokde, A.L.W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos-Orfanos, D., Poustka, L., Smolka, M.N., Jurk, S., Walter, H., Whelan, R., Schumann, G., Althoff, R.R., Garavan, H., IMAGEN Consortium, 2017. Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior. Biol. Psychiatry 82, 275–282. doi.org/10.1016/j.biopsych.2015.12.027

Magnussen, C., Niiranen, T.J., Ojeda, F.M., Gianfagna, F., Blankenberg, S., Njølstad, I., Vartiainen, E., Sans, S., Pasterkamp, G., Hughes, M., Costanzo, S., Donati, M.B., Jousilahti, P., Linneberg, A., Palosaari, T., de Gaetano, G., Bobak, M., den Ruijter, H.M., Mathiesen, E., Jørgensen, T., Söderberg, S., Kuulasmaa, K., Zeller, T., Iacoviello, L., Salomaa, V., Schnabel, R.B., BiomarCaRE Consortium, 2017a. Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe). Circulation 136, 1588–1597. doi.org/10.1161/CIRCULATIONAHA.117.028981

Magnussen, C., Ojeda, F.M., Rzayeva, N., Zeller, T., Sinning, C.R., Pfeiffer, N., Beutel, M., Blettner, M., Lackner, K.J., Blankenberg, S., Münzel, T., Rabe, K.F., Wild, P.S., Schnabel, R.B., Gutenberg Health Study investigators, 2017b. FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study. Int. J. Cardiol. 234, 64–68. doi.org/10.1016/j.ijcard.2017.02.012

Maier, D., 2017. Applying Systems Medicine in the Clinic. Current Opinion in Systems Biology. doi.org/10.1016/j.coisb.2017.04.014

Malchers, F., Ercanoglu, M., Schütte, D., Castiglione, R., Tischler, V., Michels, S., Dahmen, I., Brägelmann, J., Menon, R., Heuckmann, J.M., George, J., Ansén, S., Sos, M.L., Soltermann, A., Peifer, M., Wolf, J., Büttner, R., Thomas, R.K., 2017. Mechanisms of Primary Drug Resistance inFGFR1-Amplified Lung Cancer. Clin. Cancer Res. 23, 5527–5536. doi.org/10.1158/1078-0432.CCR-17-0478

Martin, J., Streit, F., Treutlein, J., Lang, M., Frank, J., Forstner, A.J., Degenhardt, F., Witt, S.H., Schulze, T.G., Cichon, S., Nöthen, M.M., Rietschel, M., Strohmaier, J., 2017. Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist. Psychiatr. Genet. 27, 187–196. doi.org/10.1097/YPG.0000000000000182

McDonald, M.M., Reagan, M.R., Youlten, S.E., Mohanty, S.T., Seckinger, A., Terry, R.L., Pettitt, J.A., Simic, M.K., Cheng, T.L., Morse, A., Le, L.M.T., Abi-Hanna, D., Kramer, I., Falank, C., Fairfield, H., Ghobrial, I.M., Baldock, P.A., Little, D.G., Kneissel, M., Vanderkerken, K., Bassett, J.H.D., Williams, G.R., Oyajobi, B.O., Hose, D., Phan, T.G., Croucher, P.I., 2017. Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood 129, 3452–3464. doi.org/10.1182/blood-2017-03-773341

Meißner, T., Mark, A., Williams, C., Berdel, W.E., Wiebe, S., Kerkhoff, A., Wardelmann, E., Gaiser, T., Müller-Tidow, C., Rosenstiel, P., Arnold, N., Leyland-Jones, B., Franke, A., Stanulla, M., Forster, M., 2017. Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events. Cold Spring Harb Mol Case Stud 3. doi.org/10.1101/mcs.a001677

Melin, B.S., Barnholtz-Sloan, J.S., Wrensch, M.R., Johansen, C., Il’yasova, D., Kinnersley, B., Ostrom, Q.T., Labreche, K., Chen, Y., Armstrong, G., Liu, Y., Eckel-Passow, J.E., Decker, P.A., Labussière, M., Idbaih, A., Hoang-Xuan, K., Di Stefano, A.-L., Mokhtari, K., Delattre, J.-Y., Broderick, P., Galan, P., Gousias, K., Schramm, J., Schoemaker, M.J., Fleming, S.J., Herms, S., Heilmann, S., Nöthen, M.M., Wichmann, H.-E., Schreiber, S., Swerdlow, A., Lathrop, M., Simon, M., Sanson, M., Andersson, U., Rajaraman, P., Chanock, S., Linet, M., Wang, Z., Yeager, M., GliomaScan Consortium, Wiencke, J.K., Hansen, H., McCoy, L., Rice, T., Kosel, M.L., Sicotte, H., Amos, C.I., Bernstein, J.L., Davis, F., Lachance, D., Lau, C., Merrell, R.T., Shildkraut, J., Ali-Osman, F., Sadetzki, S., Scheurer, M., Shete, S., Lai, R.K., Claus, E.B., Olson, S.H., Jenkins, R.B., Houlston, R.S., Bondy, M.L., 2017. Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nat. Genet. 49, 789–794. doi.org/10.1038/ng.3823

Merz, M., Jauch, A., Hielscher, T., Mai, E.K., Seckinger, A., Hose, D., Bertsch, U., Neben, K., Raab, M.S., Salwender, H., Blau, I.W., Lindemann, H.-W., Schmidt-Wolf, I., Scheid, C., Haenel, M., Weisel, K., Goldschmidt, H., Hillengass, J., 2017. Longitudinal fluorescence in situ hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation. Haematologica 102, 1432–1438. doi.org/10.3324/haematol.2017.168005

Messer, M., Costa, K.M., Roeper, J., Schneider, G., 2017. Multi-scale detection of rate changes in spike trains with weak dependencies. J Comput Neurosci 42, 187–201. doi.org/10.1007/s10827-016-0635-3

Metzger, M.W., Walser, S.M., Aprile-Garcia, F., Dedic, N., Chen, A., Holsboer, F., Arzt, E., Wurst, W., Deussing, J.M., 2017a. Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signal. 13, 153–170. doi.org/10.1007/s11302-016-9546-z

Metzger, M.W., Walser, S.M., Dedic, N., Aprile-Garcia, F., Jakubcakova, V., Adamczyk, M., Webb, K.J., Uhr, M., Refojo, D., Schmidt, M.V., Friess, E., Steiger, A., Kimura, M., Chen, A., Holsboer, F., Arzt, E., Wurst, W., Deussing, J.M., 2017b. Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality. J. Neurosci. 37, 11688–11700. doi.org/10.1523/JNEUROSCI.3487-16.2017

Meyer, P., Maity, P., Burkovski, A., Schwab, J., Müssel, C., Singh, K., Ferreira, F.F., Krug, L., Maier, H.J., Wlaschek, M., Wirth, T., Kestler, H.A., Scharffetter-Kochanek, K., 2017. A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence. PLoS Comput. Biol. 13, e1005741. doi.org/10.1371/journal.pcbi.1005741

Meziane, I., Huhn, S., Filho, M.I. da S., Weinhold, N., Campo, C., Nickel, J., Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Landi, S., Mitchell, J.S., Johnson, D., Jauch, A., Morgan, G.J., Houlston, R., Goldschmidt, H., Milani, P., Merlini, G., Rowcieno, D., Hawkins, P., Hegenbart, U., Palladini, G., Wechalekar, A., Försti, A., Schönland, S.O., Hemminki, K., 2017. Genome-wide association study of clinical parameters in immunoglobulin light chain amyloidosis in three patient cohorts. Haematologica 102, e411–e414. doi.org/10.3324/haematol.2017.171108

Mielenz, D., Reichel, M., Jia, T., Quinlan, E.B., Stöckl, T., Mettang, M., Zilske, D., Kirmizi-Alsan, E., Schönberger, P., Praetner, M., Huber, S.E., Amato, D., Schwarz, M., Purohit, P., Brachs, S., Spranger, J., Hess, A., Büttner, C., Ekici, A.B., Perez-Branguli, F., Winner, B., Rauschenberger, V., Banaschewski, T., Bokde, A.L.W., Büchel, C., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Martinot, J.-L., Lemaitre, H., Nees, F., Paus, T., Smolka, M.N., IMAGEN Consortium, Schambony, A., Bäuerle, T., Eulenburg, V., Alzheimer, C., Lourdusamy, A., Schumann, G., Müller, C.P., 2017. EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction. Mol. Psychiatry. doi.org/10.1038/mp.2017.63

Milaneschi, Y., Lamers, F., Peyrot, W.J., Baune, B.T., Breen, G., Dehghan, A., Forstner, A.J., Grabe, H.J., Homuth, G., Kan, C., Lewis, C., Mullins, N., Nauck, M., Pistis, G., Preisig, M., Rivera, M., Rietschel, M., Streit, F., Strohmaier, J., Teumer, A., Van der Auwera, S., Wray, N.R., Boomsma, D.I., Penninx, B.W.J.H., CHARGE Inflammation Working Group and the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 2017. Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations. JAMA Psychiatry 74, 1214–1225. doi.org/10.1001/jamapsychiatry.2017.3016

Mirdita, M., von den Driesch, L., Galiez, C., Martin, M.J., Söding, J., Steinegger, M., 2017. Uniclust databases of clustered and deeply annotated protein sequences and alignments. Nucleic Acids Res. 45, D170–D176. doi.org/10.1093/nar/gkw1081

Moessnang, C., Otto, K., Bilek, E., Schäfer, A., Baumeister, S., Hohmann, S., Poustka, L., Brandeis, D., Banaschewski, T., Tost, H., Meyer-Lindenberg, A., 2017. Differential responses of the dorsomedial prefrontal cortex and right posterior superior temporal sulcus to spontaneous mentalizing. Hum Brain Mapp 38, 3791–3803. doi.org/10.1002/hbm.23626

Mohme, M., Maire, C.L., Riecken, K., Zapf, S., Aranyossy, T., Westphal, M., Lamszus, K., Fehse, B., 2017. Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity. Mol. Ther. 25, 621–633. doi.org/10.1016/j.ymthe.2016.12.014

Mollaoglu, G., Guthrie, M.R., Böhm, S., Brägelmann, J., Can, I., Ballieu, P.M., Marx, A., George, J., Heinen, C., Chalishazar, M.D., Cheng, H., Ireland, A.S., Denning, K.E., Mukhopadhyay, A., Vahrenkamp, J.M., Berrett, K.C., Mosbruger, T.L., Wang, J., Kohan, J.L., Salama, M.E., Witt, B.L., Peifer, M., Thomas, R.K., Gertz, J., Johnson, J.E., Gazdar, A.F., Wechsler-Reya, R.J., Sos, M.L., Oliver, T.G., 2017. MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell. doi.org/10.1016/j.ccell.2016.12.005

Nava-Sedeño, J.M., Hatzikirou, H., Klages, R., Deutsch, A., 2017a. Cellular automaton models for time-correlated random walks: derivation and analysis. Sci Rep 7, 16952. doi.org/10.1038/s41598-017-17317-x

Nava-Sedeño, J.M., Hatzikirou, H., Peruani, F., Deutsch, A., 2017b. Extracting cellular automaton rules from physical Langevin equation models for single and collective cell migration. J Math Biol 75, 1075–1100. doi.org/10.1007/s00285-017-1106-9

Nees, F., Becker, S., Millenet, S., Banaschewski, T., Poustka, L., Bokde, A., Bromberg, U., Büchel, C., Conrod, P.J., Desrivières, S., Frouin, V., Gallinat, J., Garavan, H., Heinz, A., Ittermann, B., Martinot, J.-L., Papadopoulos Orfanos, D., Paus, T., Smolka, M.N., Walter, H., Whelan, R., Schumann, G., Flor, H., IMAGEN consortium, 2017. Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain? Pain 158, 212–219. doi.org/10.1097/j.pain.0000000000000720

Nelson, C.P., Goel, A., Butterworth, A.S., Kanoni, S., Webb, T.R., Marouli, E., Zeng, L., Ntalla, I., Lai, F.Y., Hopewell, J.C., Giannakopoulou, O., Jiang, T., Hamby, S.E., Di Angelantonio, E., Assimes, T.L., Bottinger, E.P., Chambers, J.C., Clarke, R., Palmer, C.N.A., Cubbon, R.M., Ellinor, P., Ermel, R., Evangelou, E., Franks, P.W., Grace, C., Gu, D., Hingorani, A.D., Howson, J.M.M., Ingelsson, E., Kastrati, A., Kessler, T., Kyriakou, T., Lehtimäki, T., Lu, X., Lu, Y., März, W., McPherson, R., Metspalu, A., Pujades-Rodriguez, M., Ruusalepp, A., Schadt, E.E., Schmidt, A.F., Sweeting, M.J., Zalloua, P.A., AlGhalayini, K., Keavney, B.D., Kooner, J.S., Loos, R.J.F., Patel, R.S., Rutter, M.K., Tomaszewski, M., Tzoulaki, I., Zeggini, E., Erdmann, J., Dedoussis, G., Björkegren, J.L.M., EPIC-CVD Consortium, CARDIoGRAMplusC4D, UK Biobank CardioMetabolic Consortium CHD working group, Schunkert, H., Farrall, M., Danesh, J., Samani, N.J., Watkins, H., Deloukas, P., 2017. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat. Genet. 49, 1385–1391. doi.org/10.1038/ng.3913

Ni, Z., Angelidou, G., Hoffmann, R., Fedorova, M., 2017a. LPPtiger software for lipidome-specific prediction and identification of oxidized phospholipids from LC-MS datasets. Sci Rep 7, 15138. doi.org/10.1038/s41598-017-15363-z

Ni, Z., Angelidou, G., Lange, M., Hoffmann, R., Fedorova, M., 2017b. LipidHunter Identifies Phospholipids by High-Throughput Processing of LC-MS and Shotgun Lipidomics Datasets. Anal. Chem. 89, 8800–8807. doi.org/10.1021/acs.analchem.7b01126

Niessner, H., Sinnberg, T., Kosnopfel, C., Smalley, K.S.M., Beck, D., Praetorius, C., Mai, M., Beissert, S., Kulms, D., Schaller, M., Garbe, C., Flaherty, K.T., Westphal, D., Wanke, I., Meier, F., 2017. BRAF Inhibitors Amplify the Proapoptotic Activity of MEK Inhibitors by Inducing ER Stress in NRAS-Mutant Melanoma. Clin. Cancer Res. 23, 6203–6214. doi.org/10.1158/1078-0432.CCR-17-0098

Nikolaus, S., Schulte, B., Al-Massad, N., Thieme, F., Schulte, D.M., Bethge, J., Rehman, A., Tran, F., Aden, K., Häsler, R., Moll, N., Schütze, G., Schwarz, M.J., Waetzig, G.H., Rosenstiel, P., Krawczak, M., Szymczak, S., Schreiber, S., 2017. Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases. Gastroenterology 153, 1504–1516.e2. doi.org/10.1053/j.gastro.2017.08.028

Noori, H.R., Schöttler, J., Ercsey-Ravasz, M., Cosa-Linan, A., Varga, M., Toroczkai, Z., Spanagel, R., 2017. A multiscale cerebral neurochemical connectome of the rat brain. PLoS Biol. 15, e2002612. doi.org/10.1371/journal.pbio.2002612

Oberhofer, J., Noori, H.R., 2017. Quantitative evaluation of cue-induced reinstatement model for evidence-based experimental optimization. Addict Biol. doi.org/10.1111/adb.12588

Otto, R., Sers, C., Leser, U., 2017. Robust in-silico identification of cancer cell lines based on next generation sequencing. Oncotarget 8, 34310–34320. doi.org/10.18632/oncotarget.16110

Pastor, V.B., Sahoo, S., Boklan, J., Schwabe, G.C., Saribeyoglu, E., Strahm, B., Lebrecht, D., Voss, M., Bryceson, Y.T., Erlacher, M., Ehninger, G., Niewisch, M., Schlegelberger, B., Baumann, I., Achermann, J.C., Shimamura, A., Hochrein, J., Tedgård, U., Nilsson, L., Hasle, H., Boerries, M., Busch, H., Niemeyer, C.M., Wlodarski, M.W., 2017. Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7. Haematologica. doi.org/10.3324/haematol.2017.180778

Peckys, D.B., Korf, U., Wiemann, S., de Jonge, N., 2017. Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers. Mol. Biol. Cell. doi.org/10.1091/mbc.E17-06-0381

Perfahl, H., Hughes, B.D., Alarcón, T., Maini, P.K., Lloyd, M.C., Reuss, M., Byrne, H.M., 2017. 3D hybrid modelling of vascular network formation. Journal of Theoretical Biology 414, 254–268. doi.org/10.1016/j.jtbi.2016.11.013

Petersen, B.-S., Fredrich, B., Hoeppner, M.P., Ellinghaus, D., Franke, A., 2017. Opportunities and challenges of whole-genome and -exome sequencing. BMC Genet. 18, 14. doi.org/10.1186/s12863-017-0479-5

Peyrot, W.J., Van der Auwera, S., Milaneschi, Y., Dolan, C.V., Madden, P.A., Sullivan, P.F., Strohmaier, J., Ripke, S., Rietschel, M., Nivard, M.G., Mullins, N., Montgomery, G.W., Henders, A.K., Heat, A.C., Fisher, H.L., Dunn, E.C., Byrne, E.M., Air, T.A., Baune, B.T., Breen, G., Levinson, D.F., Lewis, C.M., Martin, N.G., Nelson, E.N., Boomsma, D.I., Grabe, H.J., Wray, N.R., Penninx, B.W., 2017. Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5,765 subjects from the Psychiatric Genomics Consortium. Biological Psychiatry. doi.org/10.1016/j.biopsych.2017.09.009

Pfeuffer, J., Sachsenberg, T., Alka, O., Walzer, M., Fillbrunn, A., Nilse, L., Schilling, O., Reinert, K., Kohlbacher, O., 2017. OpenMS - A platform for reproducible analysis of mass spectrometry data. J. Biotechnol. 261, 142–148. doi.org/10.1016/j.jbiotec.2017.05.016

Phuah, C.-L., Dave, T., Malik, R., Raffeld, M.R., Ayres, A.M., Goldstein, J.N., Viswanathan, A., Greenberg, S.M., Jagiella, J.M., Hansen, B.M., Norrving, B., Jimenez-Conde, J., Roquer, J., Pichler, A., Enzinger, C., Montaner, J., Fernandez-Cadenas, I., Lindgren, A., Slowik, A., Schmidt, R., Biffi, A., Rost, N., Langefeld, C.D., Markus, H.S., Mitchell, B.D., Worrall, B.B., Kittner, S.J., Woo, D., Dichgans, M., Rosand, J., Anderson, C.D., METASTROKE, NINDS-SiGN Consortium, International Stroke Genetics Consortium, 2017. Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. Brain 140, 2663–2672. doi.org/10.1093/brain/awx220

Plenker, D., Riedel, M., Brägelmann, J., Dammert, M.A., Chauhan, R., Knowles, P.P., Lorenz, C., Keul, M., Bührmann, M., Pagel, O., Tischler, V., Scheel, A.H., Schütte, D., Song, Y., Stark, J., Mrugalla, F., Alber, Y., Richters, A., Engel, J., Leenders, F., Heuckmann, J.M., Wolf, J., Diebold, J., Pall, G., Peifer, M., Aerts, M., Gevaert, K., Zahedi, R.P., Buettner, R., Shokat, K.M., McDonald, N.Q., Kast, S.M., Gautschi, O., Thomas, R.K., Sos, M.L., 2017. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Sci Transl Med 9. doi.org/10.1126/scitranslmed.aah6144

Pomozi, V., Brampton, C., van de Wetering, K., Zoll, J., Calio, B., Pham, K., Owens, J.B., Marh, J., Moisyadi, S., Váradi, A., Martin, L., Bauer, C., Erdmann, J., Aherrahrou, Z., Le Saux, O., 2017. Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice. Am. J. Pathol. 187, 1258–1272. doi.org/10.1016/j.ajpath.2017.02.009

Power, R.A., Tansey, K.E., Buttenschøn, H.N., Cohen-Woods, S., Bigdeli, T., Hall, L.S., Kutalik, Z., Lee, S.H., Ripke, S., Steinberg, S., Teumer, A., Viktorin, A., Wray, N.R., Arolt, V., Baune, B.T., Boomsma, D.I., Børglum, A.D., Byrne, E.M., Castelao, E., Craddock, N., Craig, I.W., Dannlowski, U., Deary, I.J., Degenhardt, F., Forstner, A.J., Gordon, S.D., Grabe, H.J., Grove, J., Hamilton, S.P., Hayward, C., Heath, A.C., Hocking, L.J., Homuth, G., Hottenga, J.J., Kloiber, S., Krogh, J., Landén, M., Lang, M., Levinson, D.F., Lichtenstein, P., Lucae, S., MacIntyre, D.J., Madden, P., Magnusson, P.K.E., Martin, N.G., McIntosh, A.M., Middeldorp, C.M., Milaneschi, Y., Montgomery, G.W., Mors, O., Müller-Myhsok, B., Nyholt, D.R., Oskarsson, H., Owen, M.J., Padmanabhan, S., Penninx, B.W.J.H., Pergadia, M.L., Porteous, D.J., Potash, J.B., Preisig, M., Rivera, M., Shi, J., Shyn, S.I., Sigurdsson, E., Smit, J.H., Smith, B.H., Stefansson, H., Stefansson, K., Strohmaier, J., Sullivan, P.F., Thomson, P., Thorgeirsson, T.E., Van der Auwera, S., Weissman, M.M., CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium, Breen, G., Lewis, C.M., 2017. Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biol. Psychiatry 81, 325–335. doi.org/10.1016/j.biopsych.2016.05.010

Proschmann, R., Baldow, C., Rothe, T., Suttorp, M., Thiede, C., Tauer, J.T., Müller, M.C., Hochhaus, A., Roeder, I., Glauche, I., 2017. Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy. Haematologica 102, e39–e42. doi.org/10.3324/haematol.2016.154138

Pusch, S., Krausert, S., Fischer, V., Balss, J., Ott, M., Schrimpf, D., Capper, D., Sahm, F., Eisel, J., Beck, A.-C., Jugold, M., Eichwald, V., Kaulfuss, S., Panknin, O., Rehwinkel, H., Zimmermann, K., Hillig, R.C., Guenther, J., Toschi, L., Neuhaus, R., Haegebart, A., Hess-Stumpp, H., Bauser, M., Wick, W., Unterberg, A., Herold-Mende, C., Platten, M., von Deimling, A., 2017. Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo. Acta Neuropathol. 133, 629–644. doi.org/10.1007/s00401-017-1677-y

Rangrez, A.Y., Hoppe, P., Kuhn, C., Zille, E., Frank, J., Frey, N., Frank, D., 2017a. MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2. PLoS ONE 12, e0183901. doi.org/10.1371/journal.pone.0183901

Rangrez, A.Y., Pott, J., Kluge, A., Frauen, R., Stiebeling, K., Hoppe, P., Sossalla, S., Frey, N., Frank, D., 2017b. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochim. Biophys. Acta 1864, 634–644. doi.org/10.1016/j.bbamcr.2017.01.004

Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.-C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.-X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V., Poy, M.N., 2017. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nat. Neurosci. 20, 1096–1103. doi.org/10.1038/nn.4590

Razquin Navas, P., Thedieck, K., 2017. Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network. Essays Biochem. 61, 349–368. doi.org/10.1042/EBC20160086

Reifenberger, G., Wirsching, H.-G., Knobbe-Thomsen, C.B., Weller, M., 2017. Advances in the molecular genetics of gliomas - implications for classification and therapy. Nat. Rev. Clin. Oncol. 14, 434–452. doi.org/10.1038/nrclinonc.2016.204

Reisinger, E., Genthner, L., Kerssemakers, J., Kensche, P., Borufka, S., Jugold, A., Kling, A., Prinz, M., Scholz, I., Zipprich, G., Eils, R., Lawerenz, C., Eils, J., 2017. OTP: An automatized system for managing and processing NGS data. J. Biotechnol. doi.org/10.1016/j.jbiotec.2017.08.006

Rietschel, L., Streit, F., Zhu, G., McAloney, K., Kirschbaum, C., Frank, J., Hansell, N.K., Wright, M.J., McGrath, J.J., Witt, S.H., Rietschel, M., Martin, N.G., 2016. Hair Cortisol and Its Association With Psychological Risk Factors for Psychiatric Disorders: A Pilot Study in Adolescent Twins. Twin Res Hum Genet 19, 438–446. doi.org/10.1017/thg.2016.50

Röeben, B., Marquetand, J., Bender, B., Billing, H., Haack, T.B., Sanchez-Albisua, I., Schöls, L., Blom, H.J., Synofzik, M., 2017. Hemodialysis in MNGIE transiently reduces serum and urine levels of thymidine and deoxyuridine, but not CSF levels and neurological function. Orphanet J Rare Dis 12, 135. doi.org/10.1186/s13023-017-0687-0

Roese-Koerner, B., Stappert, L., Brüstle, O., 2017. Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Neurogenesis 4, e1313647. doi.org/10.1080/23262133.2017.1313647

Rokicki, D., Pajdowska, M., Trubicka, J., Thong, M.-K., Ciara, E., Piekutowska-Abramczuk, D., Pronicki, M., Sikora, R., Haidar, R., Ołtarzewski, M., Jabłońska, E., Muthukumarasamy, P., Sthaneswar, P., Gan, C.-S., Krajewska-Walasek, M., Carrozzo, R., Verrigni, D., Semeraro, M., Rizzo, C., Taurisano, R., Alhaddad, B., Kovacs-Nagy, R., Haack, T.B., Dionisi-Vici, C., Pronicka, E., Wortmann, S.B., 2017. 3-Methylglutaconic aciduria, a frequent but underrecognized finding in carbamoyl phosphate synthetase I deficiency. Clin. Chim. Acta 471, 95–100. doi.org/10.1016/j.cca.2017.05.023

Rosswog, C., Schmidt, R., Oberthuer, A., Juraeva, D., Brors, B., Engesser, A., Kahlert, Y., Volland, R., Bartenhagen, C., Simon, T., Berthold, F., Hero, B., Faldum, A., Fischer, M., 2017. Molecular Classification Substitutes for the Prognostic Variables Stage, Age, and MYCN Status in Neuroblastoma Risk Assessment. Neoplasia 19, 982–990. doi.org/10.1016/j.neo.2017.09.006

Ruf, S., Heberle, A.M., Langelaar-Makkinje, M., Gelino, S., Wilkinson, D., Gerbeth, C., Schwarz, J.J., Holzwarth, B., Warscheid, B., Meisinger, C., van Vugt, M.A.T.M., Baumeister, R., Hansen, M., Thedieck, K., 2017. PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy 13, 486–505. doi.org/10.1080/15548627.2016.1263781

Ruggeri, B., Macare, C., Stopponi, S., Jia, T., Carvalho, F.M., Robert, G., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.L., Martinot, M.-L.P., Nees, F., Papadopoulos-Orfanos, D., Paus, T., Poustka, L., Smolka, M.N., Vetter, N.C., Walter, H., Whelan, R., Sommer, W.H., Bakalkin, G., Ciccocioppo, R., Schumann, G., IMAGEN consortium, 2017. Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. J Child Psychol Psychiatry. doi.org/10.1111/jcpp.12843

Rühlemann, M.C., Heinsen, F.-A., Zenouzi, R., Lieb, W., Franke, A., Schramm, C., 2017. Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis. Gut 66, 753–754. doi.org/10.1136/gutjnl-2016-312180

Ruiz-Moreno, J.S., Hamann, L., Jin, L., Sander, L.E., Puzianowska-Kuznicka, M., Cambier, J., Witzenrath, M., Schumann, R.R., Suttorp, N., Opitz, B., CAPNETZ Study Group, 2017. The cGAS/STING pathway detects Streptococcus pneumoniae but appears dispensable for anti-pneumococcal defense in mice and humans. Infect. Immun. doi.org/10.1128/IAI.00849-17

Ryl, T., Kuchen, E.E., Bell, E., Shao, C., Flórez, A.F., Mönke, G., Gogolin, S., Friedrich, M., Lamprecht, F., Westermann, F., Höfer, T., 2017. Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug. Cell Syst 5, 237–250.e8. doi.org/10.1016/j.cels.2017.07.005

Salminen, A.V., Garrett, L., Schormair, B., Rozman, J., Giesert, F., Niedermeier, K.M., Becker, L., Rathkolb, B., Rácz, I., German Mouse Clinic Consortium, Klingenspor, M., Klopstock, T., Wolf, E., Zimmer, A., Gailus-Durner, V., Torres, M., Fuchs, H., Hrabě de Angelis, M., Wurst, W., Hölter, S.M., Winkelmann, J., 2017. Meis1: effects on motor phenotypes and the sensorimotor system in mice. Dis Model Mech 10, 981–991. doi.org/10.1242/dmm.030080

Saraiva, J.P., Oswald, M., Biering, A., Röll, D., Assmann, C., Klassert, T., Blaess, M., Czakai, K., Claus, R., Löffler, J., Slevogt, H., König, R., 2017. Fungal biomarker discovery by integration of classifiers. BMC Genomics 18, 601. doi.org/10.1186/s12864-017-4006-x

Saraiva, L.F., P, J., Zubiria-Barrera, C., Klassert, T.E., Lautenbach, M.J., Blaess, M., Claus, R.A., Slevogt, H., König, R., 2017. Combination of Classifiers Identifies Fungal-Specific Activation of Lysosome Genes in Human Monocytes. Front. Microbiol. 8. doi.org/10.3389/fmicb.2017.02366

Schaadt, N.S., Alfonso, J.C.L., Schönmeyer, R., Grote, A., Forestier, G., Wemmert, C., Krönke, N., Stoeckelhuber, M., Kreipe, H.H., Hatzikirou, H., Feuerhake, F., 2017. Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis. Breast Cancer Res. Treat. 164, 305–315. doi.org/10.1007/s10549-017-4239-z

Schapranow, M.P., Kraus, M., Danner, M., Plattner, H., 2017. IMDBfs: Bridging the gap between in-memory database technology and file-based tools for life sciences, in: 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). Presented at the 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 1133–1139. doi.org/10.1109/BIBM.2016.7822680

Schäuble, S., Stavrum, A.-K., Bockwoldt, M., Puntervoll, P., Heiland, I., 2017. SBMLmod: a Python-based web application and web service for efficient data integration and model simulation. BMC Bioinformatics 18, 314. doi.org/10.1186/s12859-017-1722-9

Schepp, J., Chou, J., Skrabl-Baumgartner, A., Arkwright, P.D., Engelhardt, K.R., Hambleton, S., Morio, T., Röther, E., Warnatz, K., Geha, R., Grimbacher, B., 2017a. 14 Years after Discovery: Clinical Follow-up on 15 Patients with Inducible Co-Stimulator Deficiency. Front. Immunol. 8. doi.org/10.3389/fimmu.2017.00964

Schepp, J., Proietti, M., Frede, N., Buchta, M., Hübscher, K., Rojas Restrepo, J., Goldacker, S., Warnatz, K., Pachlopnik Schmid, J., Duppenthaler, A., Lougaris, V., Uriarte, I., Kelly, S., Hershfield, M., Grimbacher, B., 2017b. Screening of 181 Patients With Antibody Deficiency for Deficiency of Adenosine Deaminase 2 Sheds New Light on the Disease in Adulthood. Arthritis & Rheumatology (Hoboken, N.J.) 69, 1689–1700. doi.org/10.1002/art.40147

Schmack, K., Rothkirch, M., Priller, J., Sterzer, P., 2017. Enhanced predictive signalling in schizophrenia. Hum Brain Mapp 38, 1767–1779. doi.org/10.1002/hbm.23480

Schmidt, R.E., Grimbacher, B., Witte, T., 2017. Autoimmunity and primary immunodeficiency: two sides of the same coin? Nat Rev Rheumatol 14, 7–18. doi.org/10.1038/nrrheum.2017.198

Schmitt, A., Knittel, G., Welcker, D., Yang, T.-P., George, J., Nowak, M., Leeser, U., Büttner, R., Perner, S., Peifer, M., Reinhardt, H.C., 2017. ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma. Cancer Res. 77, 3040–3056. doi.org/10.1158/0008-5472.CAN-16-3398

Schmitt, A., Martins-de-Souza, D., Akbarian, S., Cassoli, J.S., Ehrenreich, H., Fischer, A., Fonteh, A., Gattaz, W.F., Gawlik, M., Gerlach, M., Grünblatt, E., Halene, T., Hasan, A., Hashimoto, K., Kim, Y.-K., Kirchner, S.-K., Kornhuber, J., Kraus, T.F.J., Malchow, B., Nascimento, J.M., Rossner, M., Schwarz, M., Steiner, J., Talib, L., Thibaut, F., Riederer, P., Falkai, P., Members of the WFSBP Task Force on Biological Markers, 2017. Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms. World J. Biol. Psychiatry 18, 330–356. doi.org/10.1080/15622975.2016.1224929

Schmitt, M., Hückelhoven, A.G., Hundemer, M., Schmitt, A., Lipp, S., Emde, M., Salwender, H., Hänel, M., Weisel, K., Bertsch, U., Dürig, J., Ho, A.D., Blau, I.W., Goldschmidt, H., Seckinger, A., Hose, D., 2017. Frequency of expression and generation of T-cell responses against antigens on multiple myeloma cells in patients included in the GMMG-MM5 trial. Oncotarget 8, 84847–84862. doi.org/10.18632/oncotarget.11215

Schnabel, R.B., Pecen, L., Ojeda, F.M., Lucerna, M., Rzayeva, N., Blankenberg, S., Darius, H., Kotecha, D., Caterina, R.D., Kirchhof, P., 2017. Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation. Heart 103, 1024–1030. doi.org/10.1136/heartjnl-2016-310406

Schneider, M., Walter, H., Moessnang, C., Schäfer, A., Erk, S., Mohnke, S., Romund, L., Garbusow, M., Dixson, L., Heinz, A., Romanczuk-Seiferth, N., Meyer-Lindenberg, A., Tost, H., 2017. Altered DLPFC-Hippocampus Connectivity During Working Memory: Independent Replication and Disorder Specificity of a Putative Genetic Risk Phenotype for Schizophrenia. Schizophr Bull 43, 1114–1122. doi.org/10.1093/schbul/sbx001

Schroeder, C.M., Hilke, F.J., Löffler, M.W., Bitzer, M., Lenz, F., Sturm, M., 2017. A comprehensive quality control workflow for paired tumor-normal NGS experiments. Bioinformatics 33, 1721–1722. doi.org/10.1093/bioinformatics/btx032

Schubert, D., Klein, M.-C., Hassdenteufel, S., Caballero-Oteyza, A., Yang, L., Proietti, M., Bulashevska, A., Kemming, J., Kühn, J., Winzer, S., Rusch, S., Fliegauf, M., Schäffer, A.A., Pfeffer, S., Geiger, R., Cavalié, A., Cao, H., Yang, F., Li, Y., Rizzi, M., Eibel, H., Kobbe, R., Marks, A.L., Peppers, B.P., Hostoffer, R.W., Puck, J.M., Zimmermann, R., Grimbacher, B., 2017. Plasma cell deficiency in humans with heterozygous mutations in SEC61A1. J. Allergy Clin. Immunol. doi.org/10.1016/j.jaci.2017.06.042

Schulz, A.R., Stanislawiak, S., Baumgart, S., Grützkau, A., Mei, H.E., 2017. Silver nanoparticles for the detection of cell surface antigens in mass cytometry. Cytometry A 91, 25–33. doi.org/10.1002/cyto.a.22904

Schulz, C., Lai, X., Bertrams, W., Jung, A.L., Sittka-Stark, A., Herkt, C.E., Janga, H., Zscheppang, K., Stielow, C., Schulte, L., Hippenstiel, S., Vera, J., Schmeck, B., 2017. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study. Sci Rep 7, 11988. doi.org/10.1038/s41598-017-12154-4

Schulz, H., Ruppert, A.-K., Herms, S., Wolf, C., Mirza-Schreiber, N., Stegle, O., Czamara, D., Forstner, A.J., Sivalingam, S., Schoch, S., Moebus, S., Pütz, B., Hillmer, A., Fricker, N., Vatter, H., Müller-Myhsok, B., Nöthen, M.M., Becker, A.J., Hoffmann, P., Sander, T., Cichon, S., 2017. Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus. Nat Commun 8, 1511. doi.org/10.1038/s41467-017-01818-4

Schumann, B., Hahm, H.S., Parameswarappa, S.G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L.-A., Witzenrath, M., Anish, C., Pereira, C.L., Seeberger, P.H., 2017. A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine. Sci Transl Med 9. doi.org/10.1126/scitranslmed.aaf5347

Schwab, J., Burkovski, A., Siegle, L., Müssel, C., Kestler, H.A., 2017. ViSiBooL-visualization and simulation of Boolean networks with temporal constraints. Bioinformatics 33, 601–604. doi.org/10.1093/bioinformatics/btw661

Schwab, J.D., Siegle, L., Kühlwein, S.D., Kühl, M., Kestler, H.A., 2017. Stability of Signaling Pathways during Aging-A Boolean Network Approach. Biology (Basel) 6. doi.org/10.3390/biology6040046

Schwudke, D., Shevchenko, A., Hoffmann, N., Ahrends, R., 2017. Lipidomics informatics for life-science. J. Biotechnol. 261, 131–136. doi.org/10.1016/j.jbiotec.2017.08.010

Seckinger, A., Delgado, J.A., Moser, S., Moreno, L., Neuber, B., Grab, A., Lipp, S., Merino, J., Prosper, F., Emde, M., Delon, C., Latzko, M., Gianotti, R., Lüoend, R., Murr, R., Hosse, R.J., Harnisch, L.J., Bacac, M., Fauti, T., Klein, C., Zabaleta, A., Hillengass, J., Cavalcanti-Adam, E.A., Ho, A.D., Hundemer, M., Miguel, J.F.S., Strein, K., Umaña, P., Hose, D., Paiva, B., Vu, M.D., 2017. Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment. Cancer Cell 0. doi.org/10.1016/j.ccell.2017.02.002

Seeberger, P.H., Pereira, C.L., Khan, N., Xiao, G., Diago-Navarro, E., Reppe, K., Opitz, B., Fries, B.C., Witzenrath, M., 2017. A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae. Angew. Chem. Int. Ed. Engl. 56, 13973–13978. doi.org/10.1002/anie.201700964

Send, T.S., Gilles, M., Codd, V., Wolf, I., Bardtke, S., Streit, F., Strohmaier, J., Frank, J., Schendel, D., Sütterlin, M.W., Denniff, M., Laucht, M., Samani, N.J., Deuschle, M., Rietschel, M., Witt, S.H., 2017. Telomere Length in Newborns is Related to Maternal Stress During Pregnancy. Neuropsychopharmacology 42, 2407–2413. doi.org/10.1038/npp.2017.73

Senís, E., Mockenhaupt, S., Rupp, D., Bauer, T., Paramasivam, N., Knapp, B., Gronych, J., Grosse, S., Windisch, M.P., Schmidt, F., Theis, F.J., Eils, R., Lichter, P., Schlesner, M., Bartenschlager, R., Grimm, D., 2017. TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic Acids Res. 45, e3. doi.org/10.1093/nar/gkw805

Silbernagel, G., Pagel, P., Pfahlert, V., Genser, B., Scharnagl, H., Kleber, M.E., Delgado, G., Ohrui, H., Ritsch, A., Grammer, T.B., Koenig, W., März, W., 2017. High-Density Lipoprotein Subclasses, Coronary Artery Disease, and Cardiovascular Mortality. Clin. Chem. 63, 1886–1896. doi.org/10.1373/clinchem.2017.275636

Silva, L.S., Poschet, G., Nonnenmacher, Y., Becker, H.M., Sapcariu, S., Gaupel, A.-C., Schlotter, M., Wu, Y., Kneisel, N., Seiffert, M., Hell, R., Hiller, K., Lichter, P., Radlwimmer, B., 2017. Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype. EMBO Rep. 18, 2172–2185. doi.org/10.15252/embr.201744154

Sommer, C., Garbusow, M., Jünger, E., Pooseh, S., Bernhardt, N., Birkenstock, J., Schad, D.J., Jabs, B., Glöckler, T., Huys, Q.M., Heinz, A., Smolka, M.N., Zimmermann, U.S., 2017. Strong seduction: impulsivity and the impact of contextual cues on instrumental behavior in alcohol dependence. Transl Psychiatry 7, e1183. doi.org/10.1038/tp.2017.158

Sommer, F., Anderson, J.M., Bharti, R., Raes, J., Rosenstiel, P., 2017. The resilience of the intestinal microbiota influences health and disease. Nat. Rev. Microbiol. 15, 630–638. doi.org/10.1038/nrmicro.2017.58

Standl, M., Tesch, F., Baurecht, H., Rodríguez, E., Müller-Nurasyid, M., Gieger, C., Peters, A., Wang-Sattler, R., Prehn, C., Adamski, J., Kronenberg, F., Schulz, H., Koletzko, S., Schikowski, T., von Berg, A., Lehmann, I., Berdel, D., Heinrich, J., Schmitt, J., Weidinger, S., 2017. Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases. J. Invest. Dermatol. 137, 1074–1081. doi.org/10.1016/j.jid.2016.11.031

Steinegger, M., Söding, J., 2017. MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Nat. Biotechnol. 35, 1026–1028. doi.org/10.1038/nbt.3988

Stoyan, D., Pommerening, A., Hummel, M., Kopp-Schneider, A., 2017. Multiple-rater kappas for binary data: Models and interpretation. Biom J. doi.org/10.1002/bimj.201600267

Streit, F., Akdeniz, C., Haddad, L., Kumsta, R., Entringer, S., Frank, J., Yim, I.S., Zänkert, S., Witt, S.H., Kirsch, P., Rietschel, M., Wüst, S., 2017. Sex-specific association between functional neuropeptide S receptor gene (NPSR1) variants and cortisol and central stress responses. Psychoneuroendocrinology 76, 49–56. doi.org/10.1016/j.psyneuen.2016.10.027

Stricker, G., Engelhardt, A., Schulz, D., Schmid, M., Tresch, A., Gagneur, J., 2017. GenoGAM: Genome-wide generalized additive models for ChIP-seq analysis. Bioinformatics. doi.org/10.1093/bioinformatics/btx150

Strotbek, M., Schmid, S., Sànchez-Gonzàlez, I., Boerries, M., Busch, H., Olayioye, M.A., 2017. miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer. Int. J. Cancer. doi.org/10.1002/ijc.30661

Stuke, H., Stuke, H., Weilnhammer, V.A., Schmack, K., 2017. Psychotic Experiences and Overhasty Inferences Are Related to Maladaptive Learning. PLoS Comput. Biol. 13, e1005328. doi.org/10.1371/journal.pcbi.1005328

Sud, A., Thomsen, H., Law, P.J., Försti, A., Filho, M.I. da S., Holroyd, A., Broderick, P., Orlando, G., Lenive, O., Wright, L., Cooke, R., Easton, D., Pharoah, P., Dunning, A., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Zs., Muir, K., Pashayan, N., PRACTICAL consortium, Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Strandmann, E.P. von, Lightfoot, T., Kane, E., Roman, E., Lake, A., Montgomery, D., Jarrett, R.F., Swerdlow, A.J., Engert, A., Orr, N., Hemminki, K., Houlston, R.S., 2017. Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nat Commun 8, 1892. doi.org/10.1038/s41467-017-00320-1

Sulaimanov, N., Klose, M., Busch, H., Boerries, M., 2017. Understanding the mTOR signaling pathway via mathematical modeling. Wiley Interdiscip Rev Syst Biol Med 9. doi.org/10.1002/wsbm.1379

Takahashi, T.T., Vengeliene, V., Spanagel, R., 2017. Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats. Psychopharmacology (Berl.) 234, 1741–1748. doi.org/10.1007/s00213-017-4576-y

Tektonidis, M., Rohr, K., 2017. Diffeomorphic Multi-Frame Non-Rigid Registration of Cell Nuclei in 2D and 3D Live Cell Images. IEEE Trans Image Process 26, 1405–1417. doi.org/10.1109/TIP.2017.2653360

Thobe, K., Sers, C., Siebert, H., 2017. Unraveling the regulation of mTORC2 using logical modeling. Cell Commun. Signal. 15, 6. doi.org/10.1186/s12964-016-0159-5

Thole, T.M., Lodrini, M., Fabian, J., Wuenschel, J., Pfeil, S., Hielscher, T., Kopp-Schneider, A., Heinicke, U., Fulda, S., Witt, O., Eggert, A., Fischer, M., Deubzer, H.E., 2017. Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival. Cell Death Dis 8, e2635. doi.org/10.1038/cddis.2017.49

Thomsen, H., Campo, C., Weinhold, N., da Silva Filho, M.I., Pour, L., Gregora, E., Vodicka, P., Vodickova, L., Hoffmann, P., Nöthen, M.M., Jöckel, K.-H., Langer, C., Hajek, R., Goldschmidt, H., Hemminki, K., Försti, A., 2017. Genomewide association study on monoclonal gammopathy of unknown significance (MGUS). Eur. J. Haematol. 99, 70–79. doi.org/10.1111/ejh.12892

Tiedt, S., Prestel, M., Malik, R., Schieferdecker, N., Duering, M., Kautzky, V., Stoycheva, I., Böck, J., Northoff, B.H., Klein, M., Dorn, F., Krohn, K., Teupser, D., Liesz, A., Plesnila, N., Holdt, L.M., Dichgans, M., 2017. RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke. Circ. Res. 121, 970–980. doi.org/10.1161/CIRCRESAHA.117.311572

Treutlein, J., Frank, J., Streit, F., Reinbold, C.S., Juraeva, D., Degenhardt, F., Rietschel, L., Witt, S.H., Forstner, A.J., Ridinger, M., Strohmaier, J., Wodarz, N., Dukal, H., Foo, J.C., Hoffmann, P., Herms, S., Heilmann-Heimbach, S., Soyka, M., Maier, W., Gaebel, W., Dahmen, N., Scherbaum, N., Müller-Myhsok, B., Lucae, S., Ising, M., Stickel, F., Berg, T., Roggenbuck, U., Jöckel, K.-H., Scholz, H., Zimmermann, U.S., Buch, S., Sommer, W.H., Spanagel, R., Brors, B., Cichon, S., Mann, K., Kiefer, F., Hampe, J., Rosendahl, J., Nöthen, M.M., Rietschel, M., 2017a. Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. Genes (Basel) 8. doi.org/10.3390/genes8070183

Treutlein, J., Strohmaier, J., Frank, J., Witt, S.H., Rietschel, L., Forstner, A.J., Lang, M., Degenhardt, F., Dukal, H., Herms, S., Streit, F., Hoffmann, P., Cichon, S., Nöthen, M.M., Rietschel, M., 2017b. Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder. Psychiatr. Genet. 27, 34–37. doi.org/10.1097/YPG.0000000000000149

Tsoi, L.C., Stuart, P.E., Tian, C., Gudjonsson, J.E., Das, S., Zawistowski, M., Ellinghaus, E., Barker, J.N., Chandran, V., Dand, N., Duffin, K.C., Enerbäck, C., Esko, T., Franke, A., Gladman, D.D., Hoffmann, P., Kingo, K., Kõks, S., Krueger, G.G., Lim, H.W., Metspalu, A., Mrowietz, U., Mucha, S., Rahman, P., Reis, A., Tejasvi, T., Trembath, R., Voorhees, J.J., Weidinger, S., Weichenthal, M., Wen, X., Eriksson, N., Kang, H.M., Hinds, D.A., Nair, R.P., Abecasis, G.R., Elder, J.T., 2017. Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nat Commun 8, 15382. doi.org/10.1038/ncomms15382

Uhlitz, F., Sieber, A., Wyler, E., Fritsche-Guenther, R., Meisig, J., Landthaler, M., Klinger, B., Blüthgen, N., 2017. An immediate-late gene expression module decodes ERK signal duration. Mol. Syst. Biol. 13, 928.

Uhrig, S., Vandael, D., Marcantoni, A., Dedic, N., Bilbao, A., Vogt, M.A., Hirth, N., Broccoli, L., Bernardi, R.E., Schönig, K., Gass, P., Bartsch, D., Spanagel, R., Deussing, J.M., Sommer, W.H., Carbone, E., Hansson, A.C., 2017. Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence. Neuropsychopharmacology 42, 1058–1069. doi.org/10.1038/npp.2016.266

Van der Auwera, S., Wittfeld, K., Shumskaya, E., Bralten, J., Zwiers, M.P., Onnink, A.M.H., Usberti, N., Hertel, J., Völzke, H., Völker, U., Hosten, N., Franke, B., Grabe, H.J., 2017. Predicting brain structure in population-based samples with biologically informed genetic scores for schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 174, 324–332. doi.org/10.1002/ajmg.b.32519

Vengeliene, V., Bespalov, A., Roßmanith, M., Horschitz, S., Berger, S., Relo, A.L., Noori, H.R., Schneider, P., Enkel, T., Bartsch, D., Schneider, M., Behl, B., Hansson, A.C., Schloss, P., Spanagel, R., 2017. Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene. Dis Model Mech 10, 451–461. doi.org/10.1242/dmm.027623

Vilne, B., Skogsberg, J., Foroughi Asl, H., Talukdar, H.A., Kessler, T., Björkegren, J.L.M., Schunkert, H., 2017. Network analysis reveals a causal role of mitochondrial gene activity in atherosclerotic lesion formation. Atherosclerosis 267, 39–48. doi.org/10.1016/j.atherosclerosis.2017.10.019

Vogel, B.O., Lett, T.A., Erk, S., Mohnke, S., Wackerhagen, C., Brandl, E.J., Romanczuk-Seiferth, N., Otto, K., Schweiger, J.I., Tost, H., Nöthen, M.M., Rietschel, M., Degenhardt, F., Witt, S.H., Meyer-Lindenberg, A., Heinz, A., Walter, H., 2017. The influence of MIR137 on white matter fractional anisotropy and cortical surface area in individuals with familial risk for psychosis. Schizophr. Res. doi.org/10.1016/j.schres.2017.09.030

Volk, V., Reppas, A.I., Robert, P.A., Spineli, L.M., Sundarasetty, B.S., Theobald, S.J., Schneider, A., Gerasch, L., Deves Roth, C., Klöss, S., Koehl, U., von Kaisenberg, C., Figueiredo, C., Hatzikirou, H., Meyer-Hermann, M., Stripecke, R., 2017. Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization. Front Immunol 8, 1709. doi.org/10.3389/fimmu.2017.01709

von Scheidt, M., Zhao, Y., Kurt, Z., Pan, C., Zeng, L., Yang, X., Schunkert, H., Lusis, A.J., 2017. Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis. Cell Metab. 25, 248–261. doi.org/10.1016/j.cmet.2016.11.001

Wachutka, L., Gagneur, J., 2017. Measures of RNA metabolism rates: Toward a definition at the level of single bonds. Transcription 8, 75–80. doi.org/10.1080/21541264.2016.1257972

Wambach, J.A., Stettner, G.M., Haack, T.B., Writzl, K., Škofljanec, A., Maver, A., Munell, F., Ossowski, S., Bosio, M., Wegner, D.J., Shinawi, M., Baldridge, D., Alhaddad, B., Strom, T.M., Grange, D.K., Wilichowski, E., Troxell, R., Collins, J., Warner, B.B., Schmidt, R.E., Pestronk, A., Cole, F.S., Steinfeld, R., 2017. Survival among children with “Lethal” congenital contracture syndrome 11 caused by novel mutations in the gliomedin gene (GLDN). Hum. Mutat. 38, 1477–1484. doi.org/10.1002/humu.23297

Ward-Caviness, C.K., Xu, T., Aspelund, T., Thorand, B., Montrone, C., Meisinger, C., Dunger-Kaltenbach, I., Zierer, A., Yu, Z., Helgadottir, I.R., Harris, T.B., Launer, L.J., Ganna, A., Lind, L., Eiriksdottir, G., Waldenberger, M., Prehn, C., Suhre, K., Illig, T., Adamski, J., Ruepp, A., Koenig, W., Gudnason, V., Emilsson, V., Wang-Sattler, R., Peters, A., 2017. Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers. Heart 103, 1278–1285. doi.org/10.1136/heartjnl-2016-310789

Webb, T.R., Erdmann, J., Stirrups, K.E., Stitziel, N.O., Masca, N.G.D., Jansen, H., Kanoni, S., Nelson, C.P., Ferrario, P.G., König, I.R., Eicher, J.D., Johnson, A.D., Hamby, S.E., Betsholtz, C., Ruusalepp, A., Franzén, O., Schadt, E.E., Björkegren, J.L.M., Weeke, P.E., Auer, P.L., Schick, U.M., Lu, Y., Zhang, H., Dube, M.-P., Goel, A., Farrall, M., Peloso, G.M., Won, H.-H., Do, R., van Iperen, E., Kruppa, J., Mahajan, A., Scott, R.A., Willenborg, C., Braund, P.S., van Capelleveen, J.C., Doney, A.S.F., Donnelly, L.A., Asselta, R., Merlini, P.A., Duga, S., Marziliano, N., Denny, J.C., Shaffer, C., El-Mokhtari, N.E., Franke, A., Heilmann, S., Hengstenberg, C., Hoffmann, P., Holmen, O.L., Hveem, K., Jansson, J.-H., Jöckel, K.-H., Kessler, T., Kriebel, J., Laugwitz, K.L., Marouli, E., Martinelli, N., McCarthy, M.I., Van Zuydam, N.R., Meisinger, C., Esko, T., Mihailov, E., Escher, S.A., Alver, M., Moebus, S., Morris, A.D., Virtamo, J., Nikpay, M., Olivieri, O., Provost, S., AlQarawi, A., Robertson, N.R., Akinsansya, K.O., Reilly, D.F., Vogt, T.F., Yin, W., Asselbergs, F.W., Kooperberg, C., Jackson, R.D., Stahl, E., Müller-Nurasyid, M., Strauch, K., Varga, T.V., Waldenberger, M., Zeng, L., Chowdhury, R., Salomaa, V., Ford, I., Jukema, J.W., Amouyel, P., Kontto, J., Nordestgaard, B.G., Ferrières, J., Saleheen, D., Sattar, N., Surendran, P., Wagner, A., Young, R., Howson, J.M.M., Butterworth, A.S., Danesh, J., Ardissino, D., Bottinger, E.P., Erbel, R., Franks, P.W., Girelli, D., Hall, A.S., Hovingh, G.K., Kastrati, A., Lieb, W., Meitinger, T., Kraus, W.E., Shah, S.H., McPherson, R., Orho-Melander, M., Melander, O., Metspalu, A., Palmer, C.N.A., Peters, A., Rader, D.J., Reilly, M.P., Loos, R.J.F., Reiner, A.P., Roden, D.M., Tardif, J.-C., Thompson, J.R., Wareham, N.J., Watkins, H., Willer, C.J., Samani, N.J., Schunkert, H., Deloukas, P., Kathiresan, S., 2017. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology 69, 823–836. doi.org/10.1016/j.jacc.2016.11.056

Weilnhammer, V., Stuke, H., Hesselmann, G., Sterzer, P., Schmack, K., 2017. A predictive coding account of bistable perception - a model-based fMRI study. PLoS Comput. Biol. 13, e1005536. doi.org/10.1371/journal.pcbi.1005536

Weis, S., Carlos, A.R., Moita, M.R., Singh, S., Blankenhaus, B., Cardoso, S., Larsen, R., Rebelo, S., Schäuble, S., Del Barrio, L., Mithieux, G., Rajas, F., Lindig, S., Bauer, M., Soares, M.P., 2017. Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell 169, 1263–1275.e14. doi.org/10.1016/j.cell.2017.05.031

Weischenfeldt, J., Dubash, T., Drainas, A.P., Mardin, B.R., Chen, Y., Stütz, A.M., Waszak, S.M., Bosco, G., Halvorsen, A.R., Raeder, B., Efthymiopoulos, T., Erkek, S., Siegl, C., Brenner, H., Brustugun, O.T., Dieter, S.M., Northcott, P.A., Petersen, I., Pfister, S.M., Schneider, M., Solberg, S.K., Thunissen, E., Weichert, W., Zichner, T., Thomas, R., Peifer, M., Helland, A., Ball, C.R., Jechlinger, M., Sotillo, R., Glimm, H., Korbel, J.O., 2017. Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Nat. Genet. 49, 65–74. doi.org/10.1038/ng.3722

Went, M., Sud, A., Law, P.J., Johnson, D.C., Weinhold, N., Försti, A., van Duin, M., Mitchell, J.S., Chen, B., Kuiper, R., Stephens, O.W., Bertsch, U., Campo, C., Einsele, H., Gregory, W.M., Henrion, M., Hillengass, J., Hoffmann, P., Jackson, G.H., Lenive, O., Nickel, J., Nöthen, M.M., da Silva Filho, M.I., Thomsen, H., Walker, B.A., Broyl, A., Davies, F.E., Langer, C., Hansson, M., Kaiser, M., Sonneveld, P., Goldschmidt, H., Hemminki, K., Nilsson, B., Morgan, G.J., Houlston, R.S., 2017. Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach. Blood Cancer J 7, e573. doi.org/10.1038/bcj.2017.48

Wentker, P., Eberhardt, M., Dreyer, F.S., Bertrams, W., Cantone, M., Griss, K., Schmeck, B., Vera, J., 2017. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J. Immunol. 198, 2191–2201. doi.org/10.4049/jimmunol.1502513

Wilson, R., Wahl, S., Pfeiffer, L., Ward-Caviness, C.K., Kunze, S., Kretschmer, A., Reischl, E., Peters, A., Gieger, C., Waldenberger, M., 2017. The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers. BMC Genomics 18, 805. doi.org/10.1186/s12864-017-4198-0

Witoelar, A., Jansen, I.E., Wang, Y., Desikan, R.S., Gibbs, J.R., Blauwendraat, C., Thompson, W.K., Hernandez, D.G., Djurovic, S., Schork, A.J., Bettella, F., Ellinghaus, D., Franke, A., Lie, B.A., McEvoy, L.K., Karlsen, T.H., Lesage, S., Morris, H.R., Brice, A., Wood, N.W., Heutink, P., Hardy, J., Singleton, A.B., Dale, A.M., Gasser, T., Andreassen, O.A., Sharma, M., International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators, 2017. Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. JAMA Neurol 74, 780–792. doi.org/10.1001/jamaneurol.2017.0469

Witt, S.H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C.S., Treutlein, J., Degenhardt, F., Forstner, A.J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C.E., Schendel, D., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T.M., Akil, H., Alda, M., Alliey-Rodriguez, N., Andreassen, O.A., Babadjanova, G., Bass, N.J., Bauer, M., Baune, B.T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J.M., Blackwood, D.H.R., Boks, M.P., Boomsma, D.I., Børglum, A.D., Borrmann-Hassenbach, M., Brennan, P., Budde, M., Buttenschøn, H.N., Byrne, E.M., Cervantes, P., Clarke, T.-K., Craddock, N., Cruceanu, C., Curtis, D., Czerski, P.M., Dannlowski, U., Davis, T., de Geus, E.J.C., Di Florio, A., Djurovic, S., Domenici, E., Edenberg, H.J., Etain, B., Fischer, S.B., Forty, L., Fraser, C., Frye, M.A., Fullerton, J.M., Gade, K., Gershon, E.S., Giegling, I., Gordon, S.D., Gordon-Smith, K., Grabe, H.J., Green, E.K., Greenwood, T.A., Grigoroiu-Serbanescu, M., Guzman-Parra, J., Hall, L.S., Hamshere, M., Hauser, J., Hautzinger, M., Heilbronner, U., Herms, S., Hitturlingappa, S., Hoffmann, P., Holmans, P., Hottenga, J.-J., Jamain, S., Jones, I., Jones, L.A., Juréus, A., Kahn, R.S., Kammerer-Ciernioch, J., Kirov, G., Kittel-Schneider, S., Kloiber, S., Knott, S.V., Kogevinas, M., Landén, M., Leber, M., Leboyer, M., Li, Q.S., Lissowska, J., Lucae, S., Martin, N.G., Mayoral-Cleries, F., McElroy, S.L., McIntosh, A.M., McKay, J.D., McQuillin, A., Medland, S.E., Middeldorp, C.M., Milaneschi, Y., Mitchell, P.B., Montgomery, G.W., Morken, G., Mors, O., Mühleisen, T.W., Müller-Myhsok, B., Myers, R.M., Nievergelt, C.M., Nurnberger, J.I., O’Donovan, M.C., Loohuis, L.M.O., Ophoff, R., Oruc, L., Owen, M.J., Paciga, S.A., Penninx, B.W.J.H., Perry, A., Pfennig, A., Potash, J.B., Preisig, M., Reif, A., Rivas, F., Rouleau, G.A., Schofield, P.R., Schulze, T.G., Schwarz, M., Scott, L., Sinnamon, G.C.B., Stahl, E.A., Strauss, J., Turecki, G., Van der Auwera, S., Vedder, H., Vincent, J.B., Willemsen, G., Witt, C.C., Wray, N.R., Xi, H.S., Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Tadic, A., Dahmen, N., Schott, B.H., Cichon, S., Nöthen, M.M., Ripke, S., Mobascher, A., Rujescu, D., Lieb, K., Roepke, S., Schmahl, C., Bohus, M., Rietschel, M., 2017. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Transl Psychiatry 7, e1155. doi.org/10.1038/tp.2017.115

Wolk, K., Wenzel, J., Tsaousi, A., Witte-Händel, E., Babel, N., Zelenak, C., Volk, H.-D., Sterry, W., Schneider-Burrus, S., Sabat, R., 2017. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Br. J. Dermatol. 177, 1385–1393. doi.org/10.1111/bjd.15424

Xiao, X., Wang, L., Wang, C., Yuan, T.-F., Zhou, D., Zheng, F., Li, L., Grigoroiu-Serbanescu, M., Ikeda, M., Iwata, N., Takahashi, A., Kamatani, Y., Kubo, M., Preisig, M., Kutalik, Z., Castelao, E., Pistis, G., Amin, N., van Duijn, C.M., Forstner, A.J., Strohmaier, J., Hecker, J., Schulze, T.G., Müller-Myhsok, B., Reif, A., Mitchell, P.B., Martin, N.G., Schofield, P.R., Cichon, S., Nöthen, M.M., Chang, H., Luo, X.-J., Fang, Y., Yao, Y.-G., Zhang, C., Rietschel, M., Li, M., Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium, 2017. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. Transl Psychiatry 7, 1273. doi.org/10.1038/s41398-017-0019-0

Xiao, X., Zhang, C., Grigoroiu-Serbanescu, M., Wang, L., Li, L., Zhou, D., Yuan, T.-F., Wang, C., Chang, H., Wu, Y., Li, Y., Wu, D.-D., Yao, Y.-G., Li, M., 2017. The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. Mol. Psychiatry. doi.org/10.1038/mp.2017.243

Yadav, P., Ellinghaus, D., Rémy, G., Freitag-Wolf, S., Cesaro, A., Degenhardt, F., Boucher, G., Delacre, M., International IBD Genetics Consortium, Peyrin-Biroulet, L., Pichavant, M., Rioux, J.D., Gosset, P., Franke, A., Schumm, L.P., Krawczak, M., Chamaillard, M., Dempfle, A., Andersen, V., 2017. Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice. Gastroenterology 153, 550–565. doi.org/10.1053/j.gastro.2017.05.010

Yüksel, D., Dietsche, B., Forstner, A.J., Witt, S.H., Maier, R., Rietschel, M., Konrad, C., Nöthen, M.M., Dannlowski, U., Baune, B.T., Kircher, T., Krug, A., 2017. Polygenic risk for depression and the neural correlates of working memory in healthy subjects. Prog. Neuropsychopharmacol. Biol. Psychiatry 79, 67–76. doi.org/10.1016/j.pnpbp.2017.06.010

Zacharias, H.U., Rehberg, T., Mehrl, S., Richtmann, D., Wettig, T., Oefner, P.J., Spang, R., Gronwald, W., Altenbuchinger, M., 2017. Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints. J. Proteome Res. 16, 3596–3605. doi.org/10.1021/acs.jproteome.7b00325

Zacher, B., Michel, M., Schwalb, B., Cramer, P., Tresch, A., Gagneur, J., 2017. Accurate Promoter and Enhancer Identification in 127 ENCODE and Roadmap Epigenomics Cell Types and Tissues by GenoSTAN. PLoS ONE 12, e0169249. doi.org/10.1371/journal.pone.0169249

Zanon, A., Kalvakuri, S., Rakovic, A., Foco, L., Guida, M., Schwienbacher, C., Serafin, A., Rudolph, F., Trilck, M., Gruenewald, A., Stanslowsky, N., Wegner, F., Giorgio, V., Lavdas, A.A., Bodmer, R., Pramstaller, P.P., Klein, C., Hicks, A.A., Pichler, I., Seibler, P., 2017. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum. Mol. Genet. 26, 2412–2425. doi.org/10.1093/hmg/ddx132

Zerjatke, T., Gak, I.A., Kirova, D., Fuhrmann, M., Daniel, K., Gonciarz, M., Mueller, D., Glauche, I., Mansfeld, J., 2017. Quantitative Cell Cycle Analysis Based on an Endogenous All-in-One Reporter for Cell Tracking and Classification. Cell Reports 19, 1953–1966. doi.org/10.1016/j.celrep.2017.05.022

Zhou, Q., Schötterl, S., Backes, D., Brunner, E., Hahn, J.K., Ionesi, E., Aidery, P., Sticht, C., Labeit, S., Kandolf, R., Gawaz, M., Gramlich, M., 2017. Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy. Int. J. Cardiol. 230, 634–641. doi.org/10.1016/j.ijcard.2016.12.171

Zimprich, A., Östereicher, M.A., Becker, L., Dirscherl, P., Ernst, L., Fuchs, H., Gailus-Durner, V., Garrett, L., Giesert, F., Glasl, L., Hummel, A., Rozman, J., de Angelis, M.H., Vogt-Weisenhorn, D., Wurst, W., Hölter, S.M., 2017. Analysis of locomotor behavior in the German Mouse Clinic. J. Neurosci. Methods. doi.org/10.1016/j.jneumeth.2017.05.005

Zois, E., Vollstädt-Klein, S., Hoffmann, S., Reinhard, I., Charlet, K., Beck, A., Jorde, A., Kirsch, M., Walter, H., Heinz, A., Kiefer, F., 2017. Orbitofrontal structural markers of negative affect in alcohol dependence and their associations with heavy relapse-risk at 6 months post-treatment. Eur. Psychiatry 46, 16–22. doi.org/10.1016/j.eurpsy.2017.07.013

2016

Adams, H.H.H., Hibar, D.P., [...] , Schumann, G., Fornage, M., Franke, B., Debette, S., Medland, S.E., Ikram, M.A., Thompson, P.M., 2016. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat. Neurosci. 19, 1569–1582. doi.org/10.1038/nn.4398

Aherrahrou, Z., Schlossarek, S., Stoelting, S., Klinger, M., Geertz, B., Weinberger, F., Kessler, T., Aherrahrou, R., Moreth, K., Bekeredjian, R., Hrabě de Angelis, M., Just, S., Rottbauer, W., Eschenhagen, T., Schunkert, H., Carrier, L., Erdmann, J., 2016. Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis. Basic Res. Cardiol. 111, 6. doi.org/10.1007/s00395-015-0522-5

Albrecht, M., Sciumè, G., Lucarelli, P., Sauter, T., 2016. Thermodynamically constrained averaging theory for cancer growth modelling*. IFAC-PapersOnLine, Foundations of Systems Biology in Engineering - FOSBE 2016Magdeburg, Germany, 9—12 October 2016 49, 289–294. doi.org/10.1016/j.ifacol.2016.12.141

Alfonso, J.C.L., Köhn-Luque, A., Stylianopoulos, T., Feuerhake, F., Deutsch, A., Hatzikirou, H., 2016a. Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights. Sci Rep 6, 37283. doi.org/10.1038/srep37283

Alfonso, J.C.L., Schaadt, N.S., Schönmeyer, R., Brieu, N., Forestier, G., Wemmert, C., Feuerhake, F., Hatzikirou, H., 2016b. In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium. Sci Rep 6, 33322. doi.org/10.1038/srep33322

Althoff, K., Schulte, J.H., Schramm, A., 2016. Towards diagnostic application of non-coding RNAs in neuroblastoma. Expert Rev. Mol. Diagn. 16, 1307–1313. doi.org/10.1080/14737159.2016.1256207

Altmaier, E., Menni, C., Heier, M., Meisinger, C., Thorand, B., Quell, J., Kobl, M., Römisch-Margl, W., Valdes, A.M., Mangino, M., Waldenberger, M., Strauch, K., Illig, T., Adamski, J., Spector, T., Gieger, C., Suhre, K., Kastenmüller, G., 2016. The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study. PLoS ONE 11, e0153163. doi.org/10.1371/journal.pone.0153163

Alva, V., Nam, S.-Z., Söding, J., Lupas, A.N., 2016. The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis. Nucleic Acids Res. 44, W410–W415. doi.org/10.1093/nar/gkw348

Aprile-Garcia, F., Metzger, M.W., Paez-Pereda, M., Stadler, H., Acuña, M., Liberman, A.C., Senin, S.A., Gerez, J., Hoijman, E., Refojo, D., Mitkovski, M., Panhuysen, M., Stühmer, W., Holsboer, F., Deussing, J.M., Arzt, E., 2016. Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function. PLoS ONE 11, e0151862. doi.org/10.1371/journal.pone.0151862

Arakelyan, A., Nersisyan, L., Petrek, M., Löffler-Wirth, H., Binder, H., 2016. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet 7, 79. doi.org/10.3389/fgene.2016.00079

Bacher, P., Heinrich, F., Stervbo, U., Nienen, M., Vahldieck, M., Iwert, C., Vogt, K., Kollet, J., Babel, N., Sawitzki, B., Schwarz, C., Bereswill, S., Heimesaat, M.M., Heine, G., Gadermaier, G., Asam, C., Assenmacher, M., Kniemeyer, O., Brakhage, A.A., Ferreira, F., Wallner, M., Worm, M., Scheffold, A., 2016. Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 167, 1067–1078.e16. doi.org/10.1016/j.cell.2016.09.050

Bauer, C.R.K.D., Ganslandt, T., Baum, B., Christoph, J., Engel, I., Löbe, M., Mate, S., Stäubert, S., Drepper, J., Prokosch, H.-U., Winter, A., Sax, U., 2016. Integrated Data Repository Toolkit (IDRT). A Suite of Programs to Facilitate Health Analytics on Heterogeneous Medical Data. Methods Inf Med 55, 125–135. doi.org/10.3414/ME15-01-0082

Bauer, T., Trump, S., Ishaque, N., Thürmann, L., Gu, L., Bauer, M., Bieg, M., Gu, Z., Weichenhan, D., Mallm, J.-P., Röder, S., Herberth, G., Takada, E., Mücke, O., Winter, M., Junge, K.M., Grützmann, K., Rolle-Kampczyk, U., Wang, Q., Lawerenz, C., Borte, M., Polte, T., Schlesner, M., Schanne, M., Wiemann, S., Geörg, C., Stunnenberg, H.G., Plass, C., Rippe, K., Mizuguchi, J., Herrmann, C., Eils, R., Lehmann, I., 2016. Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol. Syst. Biol. 12, 861. doi.org/10.15252/msb.20156520

Baurecht, H., Hotze, M., Rodríguez, E., Manz, J., Weidinger, S., Cordell, H.J., Augustin, T., Strauch, K., 2016. Compare and Contrast Meta Analysis (CCMA): A Method for Identification of Pleiotropic Loci in Genome-Wide Association Studies. PLoS ONE 11, e0154872. doi.org/10.1371/journal.pone.0154872

Beber, M.E., Muskhelishvili, G., Hütt, M.-T., 2016. Effect of database drift on network topology and enrichment analyses: a case study for RegulonDB. Database (Oxford) 2016. doi.org/10.1093/database/baw003

Becker, C., Öcal, S., Nguyen, H.D., Phan, T., Keul, M., Simard, J.R., Rauh, D., 2016. Monitoring Conformational Changes in the Receptor Tyrosine Kinase EGFR. ChemBioChem 17, 990–994. doi.org/10.1002/cbic.201600115

Becker, R., Braun, U., Schwarz, A.J., Gass, N., Schweiger, J.I., Weber-Fahr, W., Schenker, E., Spedding, M., Clemm von Hohenberg, C., Risterucci, C., Zang, Z., Grimm, O., Tost, H., Sartorius, A., Meyer-Lindenberg, A., 2016. Species-conserved reconfigurations of brain network topology induced by ketamine. Transl Psychiatry 6, e786. doi.org/10.1038/tp.2016.53

Beckmann, B.M., Castello, A., Medenbach, J., 2016. The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions. Pflugers Arch. 468, 1029–1040. doi.org/10.1007/s00424-016-1819-4

Benz, A., Kossack, M., Auth, D., Seyler, C., Zitron, E., Juergensen, L., Katus, H.A., Hassel, D., 2016. miR-19b Regulates Ventricular Action Potential Duration in Zebrafish. Sci Rep 6, 36033. doi.org/10.1038/srep36033

Bernardi, R.E., Zohsel, K., Hirth, N., Treutlein, J., Heilig, M., Laucht, M., Spanagel, R., Sommer, W.H., 2016. A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology. Transl Psychiatry 6, e861. doi.org/10.1038/tp.2016.132

Binder, S.C., Eckweiler, D., Schulz, S., Bielecka, A., Nicolai, T., Franke, R., Häussler, S., Meyer-Hermann, M., 2016. Functional modules of sigma factor regulons guarantee adaptability and evolvability. Sci Rep 6, 22212. doi.org/10.1038/srep22212

Boecker-Schlier, R., Holz, N.E., Buchmann, A.F., Blomeyer, D., Plichta, M.M., Jennen-Steinmetz, C., Wolf, I., Baumeister, S., Treutlein, J., Rietschel, M., Meyer-Lindenberg, A., Banaschewski, T., Brandeis, D., Laucht, M., 2016. Interaction between COMT Val(158)Met polymorphism and childhood adversity affects reward processing in adulthood. Neuroimage 132, 556–570. doi.org/10.1016/j.neuroimage.2016.02.006

Boianelli, A., Sharma-Chawla, N., Bruder, D., Hernandez-Vargas, E.A., 2016. Oseltamivir PK/PD Modeling and Simulation to Evaluate Treatment Strategies against Influenza-Pneumococcus Coinfection. Front Cell Infect Microbiol 6, 60. doi.org/10.3389/fcimb.2016.00060

Braun, U., Schäfer, A., Bassett, D.S., Rausch, F., Schweiger, J.I., Bilek, E., Erk, S., Romanczuk-Seiferth, N., Grimm, O., Geiger, L.S., Haddad, L., Otto, K., Mohnke, S., Heinz, A., Zink, M., Walter, H., Schwarz, E., Meyer-Lindenberg, A., Tost, H., 2016. Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function. Proc. Natl. Acad. Sci. U.S.A. 113, 12568–12573. doi.org/10.1073/pnas.1608819113

Buck, A., Balluff, B., Voss, A., Langer, R., Zitzelsberger, H., Aichler, M., Walch, A., 2016. How Suitable is Matrix-Assisted Laser Desorption/Ionization-Time-of-Flight for Metabolite Imaging from Clinical Formalin-Fixed and Paraffin-Embedded Tissue Samples in Comparison to Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry? Anal. Chem. 88, 5281–5289. doi.org/10.1021/acs.analchem.6b00460

Budach, S., Heinig, M., Marsico, A., 2016. Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci. Genetics 203, 1629–1640. doi.org/10.1534/genetics.116.187153

Bühler, A., Kustermann, M., Bummer, T., Rottbauer, W., Sandri, M., Just, S., 2016. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci 17. doi.org/10.3390/ijms17020187

Bunn, P.A., Minna, J.D., Augustyn, A., Gazdar, A.F., Ouadah, Y., Krasnow, M.A., Berns, A., Brambilla, E., Rekhtman, N., Massion, P.P., Niederst, M., Peifer, M., Yokota, J., Govindan, R., Poirier, J.T., Byers, L.A., Wynes, M.W., McFadden, D.G., MacPherson, D., Hann, C.L., Farago, A.F., Dive, C., Teicher, B.A., Peacock, C.D., Johnson, J.E., Cobb, M.H., Wendel, H.-G., Spigel, D., Sage, J., Yang, P., Pietanza, M.C., Krug, L.M., Heymach, J., Ujhazy, P., Zhou, C., Goto, K., Dowlati, A., Christensen, C.L., Park, K., Einhorn, L.H., Edelman, M.J., Giaccone, G., Gerber, D.E., Salgia, R., Owonikoko, T., Malik, S., Karachaliou, N., Gandara, D.R., Slotman, B.J., Blackhall, F., Goss, G., Thomas, R., Rudin, C.M., Hirsch, F.R., 2016. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol 11, 453–474. doi.org/10.1016/j.jtho.2016.01.012

Cao, H., Bertolino, A., Walter, H., Schneider, M., Schäfer, A., Taurisano, P., Blasi, G., Haddad, L., Grimm, O., Otto, K., Dixson, L., Erk, S., Mohnke, S., Heinz, A., Romanczuk-Seiferth, N., Mühleisen, T.W., Mattheisen, M., Witt, S.H., Cichon, S., Noethen, M., Rietschel, M., Tost, H., Meyer-Lindenberg, A., 2016. Altered Functional Subnetwork During Emotional Face Processing: A Potential Intermediate Phenotype for Schizophrenia. JAMA Psychiatry 73, 598–605. doi.org/10.1001/jamapsychiatry.2016.0161

Charlet, K., 2016. Resilienz gegen Rückfall – protektive neuronale Mechanismen in der Alkoholabhängigkeit. Klinische Neurophysiologie. doi.org/10.1055/s-0042-104607

Clark, C.A., Gupta, H.B., Sareddy, G., Pandeswara, S., Lao, S., Yuan, B., Drerup, J.M., Padron, A., Conejo-Garcia, J., Murthy, K., Liu, Y., Turk, M.J., Thedieck, K., Hurez, V., Li, R., Vadlamudi, R., Curiel, T.J., 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. Cancer Res. 76, 6964–6974. doi.org/10.1158/0008-5472.CAN-16-0258

Coman, C., Solari, F.A., Hentschel, A., Sickmann, A., Zahedi, R.P., Ahrends, R., 2016. Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology. Mol. Cell Proteomics 15, 1453–1466. doi.org/10.1074/mcp.M115.053702

Dalle Pezze, P., Ruf, S., Sonntag, A.G., Langelaar-Makkinje, M., Hall, P., Heberle, A.M., Navas, P.R., van Eunen, K., Tölle, R.C., Schwarz, J.J., Wiese, H., Warscheid, B., Deitersen, J., Stork, B., Fäßler, E., Schäuble, S., Hahn, U., Horvatovich, P., Shanley, D.P., Thedieck, K., 2016. A systems study reveals concurrent activation of AMPK and mTOR by amino acids. Nat Commun 7, 13254. doi.org/10.1038/ncomms13254

Danhauser, K., Haack, T.B., Alhaddad, B., Melcher, M., Seibt, A., Strom, T.M., Meitinger, T., Klee, D., Mayatepek, E., Prokisch, H., Distelmaier, F., 2016a. EARS2 mutations cause fatal neonatal lactic acidosis, recurrent hypoglycemia and agenesis of corpus callosum. Metab Brain Dis. doi.org/10.1007/s11011-016-9793-2

Danhauser, K., Herebian, D., Haack, T.B., Rodenburg, R.J., Strom, T.M., Meitinger, T., Klee, D., Mayatepek, E., Prokisch, H., Distelmaier, F., 2016b. Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9. Eur. J. Hum. Genet. 24, 450–454. doi.org/10.1038/ejhg.2015.133

Dauch, D., Rudalska, R., Cossa, G., Nault, J.-C., Kang, T.-W., Wuestefeld, T., Hohmeyer, A., Imbeaud, S., Yevsa, T., Hoenicke, L., Pantsar, T., Bozko, P., Malek, N.P., Longerich, T., Laufer, S., Poso, A., Zucman-Rossi, J., Eilers, M., Zender, L., 2016. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat. Med. 22, 744–753. doi.org/10.1038/nm.4107

Dayan, P., Durstewitz, D., 2016. Editorial overview: Computational modeling: After the Middle Ages of computational neuroscience. Current Opinion in Behavioral Sciences. doi.org/10.1016/j.cobeha.2016.07.008

Deeg, K.I., Chung, I., Bauer, C., Rippe, K., 2016. Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition. Front Oncol 6, 186. doi.org/10.3389/fonc.2016.00186

Degenhardt, F., Heinemann, B., Strohmaier, J., Pfohl, M.A., Giegling, I., Hofmann, A., Ludwig, K.U., Witt, S.H., Ludwig, M., Forstner, A.J., Albus, M., Schwab, S.G., Borrmann-Hassenbach, M., Lennertz, L., Wagner, M., Hoffmann, P., Rujescu, D., Maier, W., Cichon, S., Rietschel, M., Nöthen, M.M., 2016a. Identification of rare variants in KCTD13 at the schizophrenia risk locus 16p11.2. Psychiatr. Genet. 26, 293–296. doi.org/10.1097/YPG.0000000000000145

Degenhardt, F., Krämer, L., Frank, J., Treutlein, J., Heilmann-Heimbach, S., Hecker, J., Fier, H.L., Lang, M., Witt, S.H., Koller, A.C., Mann, K., Hoffmann, S., Kiefer, F., Spanagel, R., Rietschel, M., Nöthen, M.M., 2016b. Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4. Alcohol. Clin. Exp. Res. 40, 1627–1632. doi.org/10.1111/acer.13125

Depner, M., Fuchs, S., Raabe, J., Frede, N., Glocker, C., Doffinger, R., Gkrania-Klotsas, E., Kumararatne, D., Atkinson, T.P., Schroeder, H.W., Niehues, T., Dückers, G., Stray-Pedersen, A., Baumann, U., Schmidt, R., Franco, J.L., Orrego, J., Ben-Shoshan, M., McCusker, C., Jacob, C.M.A., Carneiro-Sampaio, M., Devlin, L.A., Edgar, J.D.M., Henderson, P., Russell, R.K., Skytte, A.-B., Seneviratne, S.L., Wanders, J., Stauss, H., Meyts, I., Moens, L., Jesenak, M., Kobbe, R., Borte, S., Borte, M., Wright, D.A., Hagin, D., Torgerson, T.R., Grimbacher, B., 2016. The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1. J. Clin. Immunol. 36, 73–84. doi.org/10.1007/s10875-015-0214-9

Dieckmann, A.K., Babin, V., Harari, Y., Eils, R., König, R., Luke, B., Kupiec, M., 2016. Role of the ESCRT Complexes in Telomere Biology. MBio 7. doi.org/10.1128/mBio.01793-16

Du Bois, I., Marsico, A., Bertrams, W., Schweiger, M.R., Caffrey, B.E., Sittka-Stark, A., Eberhardt, M., Vera, J., Vingron, M., Schmeck, B.T., 2016. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J. Infect. Dis. 214, 454–463. doi.org/10.1093/infdis/jiw171

Dufner, M.C., Andre, F., Stiepak, J., Zelniker, T., Chorianopoulos, E., Preusch, M., Katus, H.A., Leuschner, F., 2016. Therapeutic hypothermia impacts leukocyte kinetics after cardiac arrest. Cardiovasc Diagn Ther 6, 199–207. doi.org/10.21037/cdt.2016.02.06

Durstewitz, D., Koppe, G., Toutounji, H., 2016. Computational models as statistical tools. Current Opinion in Behavioral Sciences, Computational modelling 11, 93–99. doi.org/10.1016/j.cobeha.2016.07.004

Eberhardt, M., Lai, X., Tomar, N., Gupta, S., Schmeck, B., Steinkasserer, A., Schuler, G., Vera, J., 2016. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol. Biol. 1386, 135–179. doi.org/10.1007/978-1-4939-3283-2_9

Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S., Rocks, O., 2016. Bimodal antagonism of PKA signalling by ARHGAP36. Nat Commun 7, 12963. doi.org/10.1038/ncomms12963

Eck, S., Wörz, S., Müller-Ott, K., Hahn, M., Biesdorf, A., Schotta, G., Rippe, K., Rohr, K., 2016. A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci. Med Image Anal 32, 18–31. doi.org/10.1016/j.media.2016.03.001

Eggert, T., Wolter, K., Ji, J., Ma, C., Yevsa, T., Klotz, S., Medina-Echeverz, J., Longerich, T., Forgues, M., Reisinger, F., Heikenwalder, M., Wang, X.W., Zender, L., Greten, T.F., 2016. Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. Cancer Cell 30, 533–547. doi.org/10.1016/j.ccell.2016.09.003

Ellinghaus, D., Jostins, L., Spain, S.L., Cortes, A., Bethune, J., Han, B., Park, Y.R., Raychaudhuri, S., Pouget, J.G., Hübenthal, M., Folseraas, T., Wang, Y., Esko, T., Metspalu, A., Westra, H.-J., Franke, L., Pers, T.H., Weersma, R.K., Collij, V., D’Amato, M., Halfvarson, J., Jensen, A.B., Lieb, W., Degenhardt, F., Forstner, A.J., Hofmann, A., International IBD Genetics Consortium (IIBDGC), International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Genetic Analysis of Psoriasis Consortium (GAPC), Psoriasis Association Genetics Extension (PAGE), Schreiber, S., Mrowietz, U., Juran, B.D., Lazaridis, K.N., Brunak, S., Dale, A.M., Trembath, R.C., Weidinger, S., Weichenthal, M., Ellinghaus, E., Elder, J.T., Barker, J.N.W.N., Andreassen, O.A., McGovern, D.P., Karlsen, T.H., Barrett, J.C., Parkes, M., Brown, M.A., Franke, A., 2016. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat. Genet. 48, 510–518. doi.org/10.1038/ng.3528

Emdin, C.A., Khera, A.V., Natarajan, P., Klarin, D., Won, H.-H., Peloso, G.M., Stitziel, N.O., Nomura, A., Zekavat, S.M., Bick, A.G., Gupta, N., Asselta, R., Duga, S., Merlini, P.A., Correa, A., Kessler, T., Wilson, J.G., Bown, M.J., Hall, A.S., Braund, P.S., Samani, N.J., Schunkert, H., Marrugat, J., Elosua, R., McPherson, R., Farrall, M., Watkins, H., Willer, C., Abecasis, G.R., Felix, J.F., Vasan, R.S., Lander, E., Rader, D.J., Danesh, J., Ardissino, D., Gabriel, S., Saleheen, D., Kathiresan, S., CHARGE–Heart Failure Consortium, CARDIoGRAM Exome Consortium, 2016. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J. Am. Coll. Cardiol. 68, 2761–2772. doi.org/10.1016/j.jacc.2016.10.033

Engel, J., Becker, C., Lategahn, J., Keul, M., Ketzer, J., Mühlenberg, T., Kollipara, L., Schultz-Fademrecht, C., Zahedi, R.P., Bauer, S., Rauh, D., 2016a. Inhibition wirkstoffresistenter Mutationsvarianten der Rezeptortyrosinkinase EGFR. Angew. Chem. n/a-n/a. doi.org/10.1002/ange.201605011

Engel, J., Lategahn, J., Rauh, D., 2016b. Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer. ACS Med Chem Lett 7, 2–5. doi.org/10.1021/acsmedchemlett.5b00475

Ernst, A., Jones, D.T.W., Maass, K.K., Rode, A., Deeg, K.I., Jebaraj, B.M.C., Korshunov, A., Hovestadt, V., Tainsky, M.A., Pajtler, K.W., Bender, S., Brabetz, S., Gröbner, S., Kool, M., Devens, F., Edelmann, J., Zhang, C., Castelo-Branco, P., Tabori, U., Malkin, D., Rippe, K., Stilgenbauer, S., Pfister, S.M., Zapatka, M., Lichter, P., 2016. Telomere dysfunction and chromothripsis. Int. J. Cancer 138, 2905–2914. doi.org/10.1002/ijc.30033

Eser, P., Wachutka, L., Maier, K.C., Demel, C., Boroni, M., Iyer, S., Cramer, P., Gagneur, J., 2016. Determinants of RNA metabolism in the Schizosaccharomyces pombe genome. Molecular Systems Biology 12, 857. doi.org/10.15252/msb.20156526

Falk, A., Heine, V.M., Harwood, A.J., Sullivan, P.F., Peitz, M., Brüstle, O., Shen, S., Sun, Y.-M., Glover, J.C., Posthuma, D., Djurovic, S., 2016. Modeling psychiatric disorders: from genomic findings to cellular phenotypes. Mol. Psychiatry 21, 1167–1179. doi.org/10.1038/mp.2016.89

Falkai, P., Malchow, B., Wetzestein, K., Nowastowski, V., Bernstein, H.-G., Steiner, J., Schneider-Axmann, T., Kraus, T., Hasan, A., Bogerts, B., Schmitz, C., Schmitt, A., 2016a. Decreased Oligodendrocyte and Neuron Number in Anterior Hippocampal Areas and the Entire Hippocampus in Schizophrenia: A Stereological Postmortem Study. Schizophr Bull 42 Suppl 1, S4–S12. doi.org/10.1093/schbul/sbv157

Falkai, P., Steiner, J., Malchow, B., Shariati, J., Knaus, A., Bernstein, H.-G., Schneider-Axmann, T., Kraus, T., Hasan, A., Bogerts, B., Schmitt, A., 2016b. Oligodendrocyte and Interneuron Density in Hippocampal Subfields in Schizophrenia and Association of Oligodendrocyte Number with Cognitive Deficits. Front Cell Neurosci 10, 78. doi.org/10.3389/fncel.2016.00078

Fauth-Bühler, M., Kiefer, F., 2016. Alcohol and the Human Brain: a Systematic Review of Recent Functional Neuroimaging and Imaging Genetics Findings. Current Addiction Reports 3, 109–124. doi.org/10.1007/s40429-016-0082-2

Fernández-Majada, V., Welz, P.-S., Ermolaeva, M.A., Schell, M., Adam, A., Dietlein, F., Komander, D., Büttner, R., Thomas, R.K., Schumacher, B., Pasparakis, M., 2016. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun 7, 12508. doi.org/10.1038/ncomms12508

Fiedler, A., Raeth, S., Theis, F.J., Hausser, A., Hasenauer, J., 2016. Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints. BMC Syst Biol 10, 80. doi.org/10.1186/s12918-016-0319-7

Fischer, T., Brothers, K.B., Erdmann, P., Langanke, M., 2016. Clinical decision-making and secondary findings in systems medicine. BMC Med Ethics 17, 32. doi.org/10.1186/s12910-016-0113-5

Flachsbart, F., Ellinghaus, D., Gentschew, L., Heinsen, F.-A., Caliebe, A., Christiansen, L., Nygaard, M., Christensen, K., Blanché, H., Deleuze, J.-F., Derbois, C., Galan, P., Büning, C., Brand, S., Peters, A., Strauch, K., Müller-Nurasyid, M., Hoffmann, P., Nöthen, M.M., Lieb, W., Franke, A., Schreiber, S., Nebel, A., 2016. Immunochip analysis identifies association of the RAD50/IL13 region with human longevity. Aging Cell 15, 585–588. doi.org/10.1111/acel.12471

Formicola, D., Petrosino, G., Lasorsa, V.A., Pignataro, P., Cimmino, F., Vetrella, S., Longo, L., Tonini, G.P., Oberthuer, A., Iolascon, A., Fischer, M., Capasso, M., 2016. An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma. J Transl Med 14, 142. doi.org/10.1186/s12967-016-0896-7

Frank, C., Fallah, M., Chen, T., Mai, E.K., Sundquist, J., Försti, A., Hemminki, K., 2016. Search for familial clustering of multiple myeloma with any cancer. Leukemia 30, 627–632. doi.org/10.1038/leu.2015.279

Franke, B., Stein, J.L., Ripke, S., Anttila, V., Hibar, D.P., van Hulzen, K.J.E., Arias-Vasquez, A., Smoller, J.W., Nichols, T.E., Neale, M.C., McIntosh, A.M., Lee, P., McMahon, F.J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O.A., Gruber, O., Sachdev, P.S., Roiz-Santiañez, R., Saykin, A.J., Ehrlich, S., Mather, K.A., Turner, J.A., Schwarz, E., Thalamuthu, A., Yao, Y., Ho, Y.Y.W., Martin, N.G., Wright, M.J., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, Enigma Consortium, O’Donovan, M.C., Thompson, P.M., Neale, B.M., Medland, S.E., Sullivan, P.F., 2016. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat. Neurosci. 19, 420–431. doi.org/10.1038/nn.4228

Fröhlich, F., Thomas, P., Kazeroonian, A., Theis, F.J., Grima, R., Hasenauer, J., 2016. Inference for Stochastic Chemical Kinetics Using Moment Equations and System Size Expansion. PLoS Comput. Biol. 12, e1005030. doi.org/10.1371/journal.pcbi.1005030

Gámez-Díaz, L., August, D., Stepensky, P., Revel-Vilk, S., Seidel, M.G., Noriko, M., Morio, T., Worth, A.J.J., Blessing, J., Van de Veerdonk, F., Feuchtinger, T., Kanariou, M., Schmitt-Graeff, A., Jung, S., Seneviratne, S., Burns, S., Belohradsky, B.H., Rezaei, N., Bakhtiar, S., Speckmann, C., Jordan, M., Grimbacher, B., 2016. The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency. J. Allergy Clin. Immunol. 137, 223–230. doi.org/10.1016/j.jaci.2015.09.025

Garn, H., Bahn, S., Baune, B.T., Binder, E.B., Bisgaard, H., Chatila, T.A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Müller-Ladner, U., Neurath, M.F., Preissner, K.T., Reinhardt, C., Rook, G., Russell, S., Schmeck, B., Stappenbeck, T., Steinhoff, U., van Os, J., Weiss, S., Zemlin, M., Renz, H., 2016. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J. Allergy Clin. Immunol. 138, 47–56. doi.org/10.1016/j.jaci.2016.02.046

Geissen, E.-M., Hasenauer, J., Heinrich, S., Hauf, S., Theis, F.J., Radde, N.E., 2016. MEMO: multi-experiment mixture model analysis of censored data. Bioinformatics 32, 2464–2472. doi.org/10.1093/bioinformatics/btw190

Ghanbari, A., Dehghany, J., Schwebs, T., Müsken, M., Häussler, S., Meyer-Hermann, M., 2016. Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms. Sci Rep 6, 32097. doi.org/10.1038/srep32097

Gietzelt, M., Höfer, T., Knaup-Gregori, P., König, R., Löpprich, M., Poos, A., Ganzinger, M., 2016. The Use of Tools, Modelling Methods, Data Types, and Endpoints in Systems Medicine: A Survey on Projects of the German e:Med-Programme. Stud Health Technol Inform 228, 670–674. doi.org/10.3233/978-1-61499-678-1-670

Gietzelt, M., Löpprich, M., Karmen, C., Knaup, P., Ganzinger, M., 2016. Models and Data Sources Used in Systems Medicine. A Systematic Literature Review. Methods Inf Med 55, 107–113. doi.org/10.3414/ME15-01-0151

Gola, D., Mahachie John, J.M., van Steen, K., König, I.R., 2016. A roadmap to multifactor dimensionality reduction methods. Brief. Bioinformatics 17, 293–308. doi.org/10.1093/bib/bbv038

Grabe, H.J., Wittfeld, K., Van der Auwera, S., Janowitz, D., Hegenscheid, K., Habes, M., Homuth, G., Barnow, S., John, U., Nauck, M., Völzke, H., Meyer Zu Schwabedissen, H., Freyberger, H.J., Hosten, N., 2016. Effect of the interaction between childhood abuse and rs1360780 of the FKBP5 gene on gray matter volume in a general population sample. Hum Brain Mapp 37, 1602–1613. doi.org/10.1002/hbm.23123

Griss, K., Bertrams, W., Sittka-Stark, A., Seidel, K., Stielow, C., Hippenstiel, S., Suttorp, N., Eberhardt, M., Wilhelm, J., Vera, J., Schmeck, B., 2016. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J. Infect. Dis. 214, 288–299. doi.org/10.1093/infdis/jiw109

Grözinger, G., Bitzer, M., Syha, R., Ketelsen, D., Nikolaou, K., Lauer, U., Horger, M., 2016. Correlation of magnetic resonance signal characteristics and perfusion parameters assessed by volume perfusion computed tomography in hepatocellular carcinoma: Impact on lesion characterization. World J Radiol 8, 683–692. doi.org/10.4329/wjr.v8.i7.683

Gu, C., Yang, Y., Sompallae, R., Xu, H., Tompkins, V.S., Holman, C., Hose, D., Goldschmidt, H., Tricot, G., Zhan, F., Janz, S., 2016. FOXM1 is a therapeutic target for high-risk multiple myeloma. Leukemia 30, 873–882. doi.org/10.1038/leu.2015.334

Gupta, S., Radhakrishnan, A., Nitin, R., Raharja-Liu, P., Lin, G., Steinmetz, L.M., Gagneur, J., Sinha, H., 2016. Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant. G3 (Bethesda) 6, 2255–2263. doi.org/10.1534/g3.116.029900

Haack, T.B., Ignatius, E., Calvo-Garrido, J., Iuso, A., Isohanni, P., Maffezzini, C., Lönnqvist, T., Suomalainen, A., Gorza, M., Kremer, L.S., Graf, E., Hartig, M., Berutti, R., Paucar, M., Svenningsson, P., Stranneheim, H., Brandberg, G., Wedell, A., Kurian, M.A., Hayflick, S.A., Venco, P., Tiranti, V., Strom, T.M., Dichgans, M., Horvath, R., Holinski-Feder, E., Freyer, C., Meitinger, T., Prokisch, H., Senderek, J., Wredenberg, A., Carroll, C.J., Klopstock, T., 2016. Absence of the Autophagy Adaptor SQSTM1/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy. Am. J. Hum. Genet. 99, 735–743. doi.org/10.1016/j.ajhg.2016.06.026

Habes, M., Erus, G., Toledo, J.B., Zhang, T., Bryan, N., Launer, L.J., Rosseel, Y., Janowitz, D., Doshi, J., Van der Auwera, S., von Sarnowski, B., Hegenscheid, K., Hosten, N., Homuth, G., Völzke, H., Schminke, U., Hoffmann, W., Grabe, H.J., Davatzikos, C., 2016. White matter hyperintensities and imaging patterns of brain ageing in the general population. Brain 139, 1164–1179. doi.org/10.1093/brain/aww008

Hadar, R., Vengeliene, V., Barroeta Hlusicke, E., Canals, S., Noori, H.R., Wieske, F., Rummel, J., Harnack, D., Heinz, A., Spanagel, R., Winter, C., 2016. Paradoxical augmented relapse in alcohol-dependent rats during deep-brain stimulation in the nucleus accumbens. Transl Psychiatry 6, e840. doi.org/10.1038/tp.2016.100

Hägele, C., Friedel, E., Schlagenhauf, F., Sterzer, P., Beck, A., Bermpohl, F., Stoy, M., Held-Poschardt, D., Wittmann, A., Ströhle, A., Heinz, A., 2016. Affective responses across psychiatric disorders-A dimensional approach. Neurosci. Lett. 623, 71–78. doi.org/10.1016/j.neulet.2016.04.037

Hasan, A., Guse, B., Cordes, J., Wölwer, W., Winterer, G., Gaebel, W., Langguth, B., Landgrebe, M., Eichhammer, P., Frank, E., Hajak, G., Ohmann, C., Verde, P.E., Rietschel, M., Ahmed, R., Honer, W.G., Malchow, B., Karch, S., Schneider-Axmann, T., Falkai, P., Wobrock, T., 2016. Cognitive Effects of High-Frequency rTMS in Schizophrenia Patients With Predominant Negative Symptoms: Results From a Multicenter Randomized Sham-Controlled Trial. Schizophr Bull 42, 608–618. doi.org/10.1093/schbul/sbv142

Häsler, R., Sheibani-Tezerji, R., Sinha, A., Barann, M., Rehman, A., Esser, D., Aden, K., Knecht, C., Brandt, B., Nikolaus, S., Schäuble, S., Kaleta, C., Franke, A., Fretter, C., Müller, W., Hütt, M.-T., Krawczak, M., Schreiber, S., Rosenstiel, P., 2016. Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease. Gut. doi.org/10.1136/gutjnl-2016-311651

Hass, J., Hertäg, L., Durstewitz, D., 2016. A Detailed Data-Driven Network Model of Prefrontal Cortex Reproduces Key Features of In Vivo Activity. PLoS Comput. Biol. 12, e1004930. doi.org/10.1371/journal.pcbi.1004930

Hauser, M., Steinegger, M., Söding, J., 2016. MMseqs software suite for fast and deep clustering and searching of large protein sequence sets. Bioinformatics 32, 1323–1330. doi.org/10.1093/bioinformatics/btw006

Heilbronner, U., Gade, K., Herms, S., Strohmaier, J., Lang, M., Nöthen, M.M., Rietschel, M., Schulze, T.G., Degenhardt, F., 2016. Effect of copy number variant burden on Global Assessment of Functioning in schizophrenia. Psychiatr. Genet. 26, 184–185. doi.org/10.1097/YPG.0000000000000135

Heinsen, F.-A., Fangmann, D., Müller, N., Schulte, D.M., Rühlemann, M.C., Türk, K., Settgast, U., Lieb, W., Baines, J.F., Schreiber, S., Franke, A., Laudes, M., 2016. Beneficial Effects of a Dietary Weight Loss Intervention on Human Gut Microbiome Diversity and Metabolism Are Not Sustained during Weight Maintenance. Obes Facts 9, 379–391. doi.org/10.1159/000449506

Heinz, A., Beck, A., Rapp, M.A., 2016a. Alcohol as an Environmental Mortality Hazard. JAMA Psychiatry 73, 549–550. doi.org/10.1001/jamapsychiatry.2016.0399

Heinz, A., Schlagenhauf, F., Beck, A., Wackerhagen, C., 2016b. Dimensional psychiatry: mental disorders as dysfunctions of basic learning mechanisms. J Neural Transm (Vienna) 123, 809–821. doi.org/10.1007/s00702-016-1561-2

Henckens, M.J.A.G., Deussing, J.M., Chen, A., 2016. Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat. Rev. Neurosci. 17, 636–651. doi.org/10.1038/nrn.2016.94

Henssen, A., Althoff, K., Odersky, A., Beckers, A., Koche, R., Speleman, F., Schäfers, S., Bell, E., Nortmeyer, M., Westermann, F., De Preter, K., Florin, A., Heukamp, L., Spruessel, A., Astrahanseff, K., Lindner, S., Sadowski, N., Schramm, A., Astorgues-Xerri, L., Riveiro, M.E., Eggert, A., Cvitkovic, E., Schulte, J.H., 2016. Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition. Clin. Cancer Res. 22, 2470–2481. doi.org/10.1158/1078-0432.CCR-15-1449

Hinds, D.A., Buil, A., Ziemek, D., Martinez-Perez, A., Malik, R., Folkersen, L., Germain, M., Mälarstig, A., Brown, A., Soria, J.M., Dichgans, M., Bing, N., Franco-Cereceda, A., Souto, J.C., Dermitzakis, E.T., Hamsten, A., Worrall, B.B., Tung, J.Y., METASTROKE Consortium, INVENT Consortium, Sabater-Lleal, M., 2016. Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. Hum. Mol. Genet. 25, 1867–1874. doi.org/10.1093/hmg/ddw037

Hirth, N., Meinhardt, M.W., Noori, H.R., Salgado, H., Torres-Ramirez, O., Uhrig, S., Broccoli, L., Vengeliene, V., Roßmanith, M., Perreau-Lenz, S., Köhr, G., Sommer, W.H., Spanagel, R., Hansson, A.C., 2016. Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence. Proc. Natl. Acad. Sci. U.S.A. doi.org/10.1073/pnas.1506012113

Hirth, S., Bühler, A., Bührdel, J.B., Rudeck, S., Dahme, T., Rottbauer, W., Just, S., 2016. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE 11, e0150323. doi.org/10.1371/journal.pone.0150323

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M.P., Matheson, N.J., Patten, D.A., Shetty, S., Parry, A.J., Menon, S., Salama, R., Antrobus, R., Tomimatsu, K., Howat, W., Lehner, P.J., Zender, L., Narita, M., 2016. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat. Cell Biol. 18, 979–992. doi.org/10.1038/ncb3397

Höfer, T., Barile, M., Flossdorf, M., 2016. Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system. Curr. Opin. Biotechnol. 39, 150–156. doi.org/10.1016/j.copbio.2016.04.001

Hoffmann, A., Ziller, M., Spengler, D., 2016. The Future is The Past: Methylation QTLs in Schizophrenia. Genes (Basel) 7. doi.org/10.3390/genes7120104

Hoffmann, S., Clauss, S., Berger, I.M., Weiß, B., Montalbano, A., Röth, R., Bucher, M., Klier, I., Wakili, R., Seitz, H., Schulze-Bahr, E., Katus, H.A., Flachsbart, F., Nebel, A., Guenther, S.P., Bagaev, E., Rottbauer, W., Kääb, S., Just, S., Rappold, G.A., 2016. Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. Basic Res. Cardiol. 111, 36. doi.org/10.1007/s00395-016-0557-2

Holzerova, E., Danhauser, K., Haack, T.B., Kremer, L.S., Melcher, M., Ingold, I., Kobayashi, S., Terrile, C., Wolf, P., Schaper, J., Mayatepek, E., Baertling, F., Friedmann Angeli, J.P., Conrad, M., Strom, T.M., Meitinger, T., Prokisch, H., Distelmaier, F., 2016. Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration. Brain 139, 346–354. doi.org/10.1093/brain/awv350

Hou, L., Bergen, S.E., Akula, N., Song, J., Hultman, C.M., Landén, M., Adli, M., Alda, M., Ardau, R., Arias, B., Aubry, J.-M., Backlund, L., Badner, J.A., Barrett, T.B., Bauer, M., Baune, B.T., Bellivier, F., Benabarre, A., Bengesser, S., Berrettini, W.H., Bhattacharjee, A.K., Biernacka, J.M., Birner, A., Bloss, C.S., Brichant-Petitjean, C., Bui, E.T., Byerley, W., Cervantes, P., Chillotti, C., Cichon, S., Colom, F., Coryell, W., Craig, D.W., Cruceanu, C., Czerski, P.M., Davis, T., Dayer, A., Degenhardt, F., Del Zompo, M., DePaulo, J.R., Edenberg, H.J., Étain, B., Falkai, P., Foroud, T., Forstner, A.J., Frisén, L., Frye, M.A., Fullerton, J.M., Gard, S., Garnham, J.S., Gershon, E.S., Goes, F.S., Greenwood, T.A., Grigoroiu-Serbanescu, M., Hauser, J., Heilbronner, U., Heilmann-Heimbach, S., Herms, S., Hipolito, M., Hitturlingappa, S., Hoffmann, P., Hofmann, A., Jamain, S., Jiménez, E., Kahn, J.-P., Kassem, L., Kelsoe, J.R., Kittel-Schneider, S., Kliwicki, S., Koller, D.L., König, B., Lackner, N., Laje, G., Lang, M., Lavebratt, C., Lawson, W.B., Leboyer, M., Leckband, S.G., Liu, C., Maaser, A., Mahon, P.B., Maier, W., Maj, M., Manchia, M., Martinsson, L., McCarthy, M.J., McElroy, S.L., McInnis, M.G., McKinney, R., Mitchell, P.B., Mitjans, M., Mondimore, F.M., Monteleone, P., Mühleisen, T.W., Nievergelt, C.M., Nöthen, M.M., Novák, T., Nurnberger, J.I., Nwulia, E.A., Ösby, U., Pfennig, A., Potash, J.B., Propping, P., Reif, A., Reininghaus, E., Rice, J., Rietschel, M., Rouleau, G.A., Rybakowski, J.K., Schalling, M., Scheftner, W.A., Schofield, P.R., Schork, N.J., Schulze, T.G., Schumacher, J., Schweizer, B.W., Severino, G., Shekhtman, T., Shilling, P.D., Simhandl, C., Slaney, C.M., Smith, E.N., Squassina, A., Stamm, T., Stopkova, P., Streit, F., Strohmaier, J., Szelinger, S., Tighe, S.K., Tortorella, A., Turecki, G., Vieta, E., Volkert, J., Witt, S.H., Wright, A., Zandi, P.P., Zhang, P., Zollner, S., McMahon, F.J., 2016a. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder. Hum. Mol. Genet. 25, 3383–3394. doi.org/10.1093/hmg/ddw181

Hou, L., Heilbronner, U., Degenhardt, F., Adli, M., Akiyama, K., Akula, N., Ardau, R., Arias, B., Backlund, L., Banzato, C.E.M., Benabarre, A., Bengesser, S., Bhattacharjee, A.K., Biernacka, J.M., Birner, A., Brichant-Petitjean, C., Bui, E.T., Cervantes, P., Chen, G.-B., Chen, H.-C., Chillotti, C., Cichon, S., Clark, S.R., Colom, F., Cousins, D.A., Cruceanu, C., Czerski, P.M., Dantas, C.R., Dayer, A., Étain, B., Falkai, P., Forstner, A.J., Frisén, L., Fullerton, J.M., Gard, S., Garnham, J.S., Goes, F.S., Grof, P., Gruber, O., Hashimoto, R., Hauser, J., Herms, S., Hoffmann, P., Hofmann, A., Jamain, S., Jiménez, E., Kahn, J.-P., Kassem, L., Kittel-Schneider, S., Kliwicki, S., König, B., Kusumi, I., Lackner, N., Laje, G., Landén, M., Lavebratt, C., Leboyer, M., Leckband, S.G., Jaramillo, C.A.L., MacQueen, G., Manchia, M., Martinsson, L., Mattheisen, M., McCarthy, M.J., McElroy, S.L., Mitjans, M., Mondimore, F.M., Monteleone, P., Nievergelt, C.M., Nöthen, M.M., Ösby, U., Ozaki, N., Perlis, R.H., Pfennig, A., Reich-Erkelenz, D., Rouleau, G.A., Schofield, P.R., Schubert, K.O., Schweizer, B.W., Seemüller, F., Severino, G., Shekhtman, T., Shilling, P.D., Shimoda, K., Simhandl, C., Slaney, C.M., Smoller, J.W., Squassina, A., Stamm, T., Stopkova, P., Tighe, S.K., Tortorella, A., Turecki, G., Volkert, J., Witt, S., Wright, A., Young, L.T., Zandi, P.P., Potash, J.B., DePaulo, J.R., Bauer, M., Reininghaus, E.Z., Novák, T., Aubry, J.-M., Maj, M., Baune, B.T., Mitchell, P.B., Vieta, E., Frye, M.A., Rybakowski, J.K., Kuo, P.-H., Kato, T., Grigoroiu-Serbanescu, M., Reif, A., Del Zompo, M., Bellivier, F., Schalling, M., Wray, N.R., Kelsoe, J.R., Alda, M., Rietschel, M., McMahon, F.J., Schulze, T.G., 2016b. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet 387, 1085–1093. doi.org/10.1016/S0140-6736(16)00143-4

Hross, S., Hasenauer, J., 2016. Analysis of CFSE time-series data using division-, age- and label-structured population models. Bioinformatics 32, 2321–2329. doi.org/10.1093/bioinformatics/btw131

Ikram, F., Ackermann, S., Kahlert, Y., Volland, R., Roels, F., Engesser, A., Hertwig, F., Kocak, H., Hero, B., Dreidax, D., Henrich, K.-O., Berthold, F., Nürnberg, P., Westermann, F., Fischer, M., 2016. Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma. Mol Oncol 10, 344–359. doi.org/10.1016/j.molonc.2015.10.020

International Cancer Genome Consortium PedBrain Tumor Project, 2016. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. Nat. Med. 22, 1314–1320. doi.org/10.1038/nm.4204

Isles, A.R., Ingason, A., Lowther, C., Walters, J., Gawlick, M., Stöber, G., Rees, E., Martin, J., Little, R.B., Potter, H., Georgieva, L., Pizzo, L., Ozaki, N., Aleksic, B., Kushima, I., Ikeda, M., Iwata, N., Levinson, D.F., Gejman, P.V., Shi, J., Sanders, A.R., Duan, J., Willis, J., Sisodiya, S., Costain, G., Werge, T.M., Degenhardt, F., Giegling, I., Rujescu, D., Hreidarsson, S.J., Saemundsen, E., Ahn, J.W., Ogilvie, C., Girirajan, S.D., Stefansson, H., Stefansson, K., O’Donovan, M.C., Owen, M.J., Bassett, A., Kirov, G., 2016. Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders. PLoS Genet. 12, e1005993. doi.org/10.1371/journal.pgen.1005993

Jia, T., Macare, C., Desrivières, S., Gonzalez, D.A., Tao, C., Ji, X., Ruggeri, B., Nees, F., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Bromberg, U., Büchel, C., Conrod, P.J., Dove, R., Frouin, V., Gallinat, J., Garavan, H., Gowland, P.A., Heinz, A., Ittermann, B., Lathrop, M., Lemaitre, H., Martinot, J.-L., Paus, T., Pausova, Z., Poline, J.-B., Rietschel, M., Robbins, T., Smolka, M.N., Müller, C.P., Feng, J., Rothenfluh, A., Flor, H., Schumann, G., IMAGEN Consortium, 2016. Neural basis of reward anticipation and its genetic determinants. Proc. Natl. Acad. Sci. U.S.A. doi.org/10.1073/pnas.1503252113

Johnson, D.C., Weinhold, N., Mitchell, J., Chen, B., Stephens, O.W., Försti, A., Nickel, J., Kaiser, M., Gregory, W.A., Cairns, D., Jackson, G.H., Hoffmann, P., Noethen, M.M., Hillengass, J., Bertsch, U., Barlogie, B., Davis, F.E., Hemminki, K., Goldschmidt, H., Houlston, R.S., Morgan, G.J., 2016. Genetic factors influencing the risk of multiple myeloma bone disease. Leukemia 30, 883–888. doi.org/10.1038/leu.2015.342

Johnson, D.C., Weinhold, N., Mitchell, J.S., Chen, B., Kaiser, M., Begum, D.B., Hillengass, J., Bertsch, U., Gregory, W.A., Cairns, D., Jackson, G.H., Försti, A., Nickel, J., Hoffmann, P., Nöethen, M.M., Stephens, O.W., Barlogie, B., Davis, F.E., Hemminki, K., Goldschmidt, H., Houlston, R.S., Morgan, G.J., 2016. Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma. Nat Commun 7, 10290. doi.org/10.1038/ncomms10290

Jollans, L., Zhipeng, C., Icke, I., Greene, C., Kelly, C., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P.J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Paus, T., Smolka, M.N., Walter, H., Schumann, G., Whelan, R., 2016. Ventral Striatum Connectivity During Reward Anticipation in Adolescent Smokers. Dev Neuropsychol 41, 6–21. doi.org/10.1080/87565641.2016.1164172

Jung, A.L., Stoiber, C., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2016. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 12, e1005592. doi.org/10.1371/journal.ppat.1005592

Jünger, E., Gan, G., Mick, I., Seipt, C., Markovic, A., Sommer, C., Plawecki, M.H., O’Connor, S., Smolka, M.N., Zimmermann, U.S., 2016. Adolescent Women Induce Lower Blood Alcohol Levels Than Men in a Laboratory Alcohol Self-Administration Experiment. Alcohol. Clin. Exp. Res. 40, 1769–1778. doi.org/10.1111/acer.13122

Jürchott, K., Schulz, A.R., Bozzetti, C., Pohlmann, D., Stervbo, U., Warth, S., Mälzer, J.N., Waldner, J., Schweiger, B., Olek, S., Grützkau, A., Babel, N., Thiel, A., Neumann, A.U., 2016. Highly Predictive Model for a Protective Immune Response to the A(H1N1)pdm2009 Influenza Strain after Seasonal Vaccination. PLoS ONE 11, e0150812. doi.org/10.1371/journal.pone.0150812

Just, S., Hirth, S., Berger, I.M., Fishman, M.C., Rottbauer, W., 2016a. The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation. Biochem. Biophys. Res. Commun. 477, 581–588. doi.org/10.1016/j.bbrc.2016.06.088

Just, S., Raphel, L., Berger, I.M., Bühler, A., Keßler, M., Rottbauer, W., 2016b. Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. PLoS ONE 11, e0167306. doi.org/10.1371/journal.pone.0167306

Kessler, T., Erdmann, J., Vilne, B., Bruse, P., Kurowski, V., Diemert, P., Schunkert, H., Sager, H.B., 2016a. Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism. J Transl Med 14, 120. doi.org/10.1186/s12967-016-0886-9

Kessler, T., Vilne, B., Schunkert, H., 2016b. The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease. EMBO Mol Med 8, 688–701. doi.org/10.15252/emmm.201506174

Khera, A.V., Won, H.-H., Peloso, G.M., Lawson, K.S., Bartz, T.M., Deng, X., van Leeuwen, E.M., Natarajan, P., Emdin, C.A., Bick, A.G., Morrison, A.C., Brody, J.A., Gupta, N., Nomura, A., Kessler, T., Duga, S., Bis, J.C., van Duijn, C.M., Cupples, L.A., Psaty, B., Rader, D.J., Danesh, J., Schunkert, H., McPherson, R., Farrall, M., Watkins, H., Lander, E., Wilson, J.G., Correa, A., Boerwinkle, E., Merlini, P.A., Ardissino, D., Saleheen, D., Gabriel, S., Kathiresan, S., 2016. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J. Am. Coll. Cardiol. 67, 2578–2589. doi.org/10.1016/j.jacc.2016.03.520

Kirschner, F., Reppe, K., Andresen, N., Witzenrath, M., Ebstein, F., Kloetzel, P.-M., 2016. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS ONE 11, e0153847. doi.org/10.1371/journal.pone.0153847

Kirsten, H., Scholz, M., Kovacs, P., Grallert, H., Peters, A., Strauch, K., Frank, J., Rietschel, M., Nöthen, M.M., Witt, H., Rosendahl, J., 2016. Genetic variants of lipase activity in chronic pancreatitis. Gut 65, 184–185. doi.org/10.1136/gutjnl-2015-309521

Knacke, H., Pietzner, M., Do, K.T., Römisch-Margl, W., Kastenmüller, G., Völker, U., Völzke, H., Krumsiek, J., Artati, A., Wallaschofski, H., Nauck, M., Suhre, K., Adamski, J., Friedrich, N., 2016. Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study. J. Clin. Endocrinol. Metab. 101, 4730–4742. doi.org/10.1210/jc.2016-2588

Knecht, C., Fretter, C., Rosenstiel, P., Krawczak, M., Hütt, M.-T., 2016. Distinct metabolic network states manifest in the gene expression profiles of pediatric inflammatory bowel disease patients and controls. Sci Rep 6, 32584. doi.org/10.1038/srep32584

Koch, J., Feichtinger, R.G., Freisinger, P., Pies, M., Schrödl, F., Iuso, A., Sperl, W., Mayr, J.A., Prokisch, H., Haack, T.B., 2016. Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy. J. Med. Genet. 53, 270–278. doi.org/10.1136/jmedgenet-2015-103500

König, I.R., Auerbach, J., Gola, D., Held, E., Holzinger, E.R., Legault, M.-A., Sun, R., Tintle, N., Yang, H.-C., 2016. Machine learning and data mining in complex genomic data--a review on the lessons learned in Genetic Analysis Workshop 19. BMC Genet. 17 Suppl 2, 1. doi.org/10.1186/s12863-015-0315-8

Kopajtich, R., Murayama, K., Janecke, A.R., Haack, T.B., Breuer, M., Knisely, A.S., Harting, I., Ohashi, T., Okazaki, Y., Watanabe, D., Tokuzawa, Y., Kotzaeridou, U., Kölker, S., Sauer, S., Carl, M., Straub, S., Entenmann, A., Gizewski, E., Feichtinger, R.G., Mayr, J.A., Lackner, K., Strom, T.M., Meitinger, T., Müller, T., Ohtake, A., Hoffmann, G.F., Prokisch, H., Staufner, C., 2016. Biallelic IARS Mutations Cause Growth Retardation with Prenatal Onset, Intellectual Disability, Muscular Hypotonia, and Infantile Hepatopathy. Am. J. Hum. Genet. 99, 414–422. doi.org/10.1016/j.ajhg.2016.05.027

Kordaß, T., Weber, C.E.M., Oswald, M., Ast, V., Bernhardt, M., Novak, D., Utikal, J., Eichmüller, S.B., König, R., 2016. SOX5 is involved in balanced MITF regulation in human melanoma cells. BMC Med Genomics 9, 10. doi.org/10.1186/s12920-016-0170-0

Kremer, L.S., Distelmaier, F., Alhaddad, B., Hempel, M., Iuso, A., Küpper, C., Mühlhausen, C., Kovacs-Nagy, R., Satanovskij, R., Graf, E., Berutti, R., Eckstein, G., Durbin, R., Sauer, S., Hoffmann, G.F., Strom, T.M., Santer, R., Meitinger, T., Klopstock, T., Prokisch, H., Haack, T.B., 2016. Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy. Am. J. Hum. Genet. 98, 358–362. doi.org/10.1016/j.ajhg.2015.12.009

Krumsiek, J., Bartel, J., Theis, F.J., 2016. Computational approaches for systems metabolomics. Curr. Opin. Biotechnol. 39, 198–206. doi.org/10.1016/j.copbio.2016.04.009

Kuhn, M., Stange, T., Herold, S., Thiede, C., Roeder, I., 2016. Finding small somatic structural variants in exome sequencing data: a machine learning approach. Comput Stat 1–14. doi.org/10.1007/s00180-016-0674-2

La Piana, R., Cayami, F.K., Tran, L.T., Guerrero, K., van Spaendonk, R., Õunap, K., Pajusalu, S., Haack, T., Wassmer, E., Timmann, D., Mierzewska, H., Poll-Thé, B.T., Patel, C., Cox, H., Atik, T., Onay, H., Ozkınay, F., Vanderver, A., van der Knaap, M.S., Wolf, N.I., Bernard, G., 2016. Diffuse hypomyelination is not obligate for POLR3-related disorders. Neurology 86, 1622–1626. doi.org/10.1212/WNL.0000000000002612

Lacour, A., Ellinghaus, D., Schreiber, S., Franke, A., Becker, T., 2016. Haplotype synthesis analysis reveals functional variants underlying known genome-wide associated susceptibility loci. Bioinformatics 32, 2136–2142. doi.org/10.1093/bioinformatics/btw125

Lai, X., Wolkenhauer, O., Vera, J., 2016. Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res. 44, 6019–6035. doi.org/10.1093/nar/gkw550

Laimighofer, M., Krumsiek, J., Buettner, F., Theis, F.J., 2016. Unbiased Prediction and Feature Selection in High-Dimensional Survival Regression. J. Comput. Biol. 23, 279–290. doi.org/10.1089/cmb.2015.0192

Lang, M., Leménager, T., Streit, F., Fauth-Bühler, M., Frank, J., Juraeva, D., Witt, S.H., Degenhardt, F., Hofmann, A., Heilmann-Heimbach, S., Kiefer, F., Brors, B., Grabe, H.-J., John, U., Bischof, A., Bischof, G., Völker, U., Homuth, G., Beutel, M., Lind, P.A., Medland, S.E., Slutske, W.S., Martin, N.G., Völzke, H., Nöthen, M.M., Meyer, C., Rumpf, H.-J., Wurst, F.M., Rietschel, M., Mann, K.F., 2016. Genome-wide association study of pathological gambling. Eur. Psychiatry 36, 38–46. doi.org/10.1016/j.eurpsy.2016.04.001

Lausser, L., Schmid, F., Schirra, L.-R., Wilhelm, A.F.X., Kestler, H.A., 2016. Rank-based classifiers for extremely high-dimensional gene expression data. Adv Data Anal Classif 1–20. doi.org/10.1007/s11634-016-0277-3

Li, M., Huang, L., Grigoroiu-Serbanescu, M., Bergen, S.E., Landén, M., Hultman, C.M., Forstner, A.J., Strohmaier, J., Hecker, J., Schulze, T.G., Müller-Myhsok, B., Reif, A., Mitchell, P.B., Martin, N.G., Cichon, S., Nöthen, M.M., Alkelai, A., Lerer, B., Jamain, S., Leboyer, M., Bellivier, F., Etain, B., Kahn, J.-P., Henry, C., Rietschel, M., MooDS Consortium, Swedish Bipolar Study Group, 2016. Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis. Mol. Neurobiol. 53, 6608–6619. doi.org/10.1007/s12035-015-9559-6

Lienau, J., Müller-Redetzky, H., Suttorp, N., Witzenrath, M., 2016. [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia]. Pneumologie 70, 372–378. doi.org/10.1055/s-0035-1563788

Ligthart, S., Marzi, C., Aslibekyan, S., Mendelson, M.M., Conneely, K.N., Tanaka, T., Colicino, E., Waite, L.L., Joehanes, R., Guan, W., Brody, J.A., Elks, C., Marioni, R., Jhun, M.A., Agha, G., Bressler, J., Ward-Caviness, C.K., Chen, B.H., Huan, T., Bakulski, K., Salfati, E.L., WHI-EMPC Investigators, Fiorito, G., CHARGE epigenetics of Coronary Heart Disease, Wahl, S., Schramm, K., Sha, J., Hernandez, D.G., Just, A.C., Smith, J.A., Sotoodehnia, N., Pilling, L.C., Pankow, J.S., Tsao, P.S., Liu, C., Zhao, W., Guarrera, S., Michopoulos, V.J., Smith, A.K., Peters, M.J., Melzer, D., Vokonas, P., Fornage, M., Prokisch, H., Bis, J.C., Chu, A.Y., Herder, C., Grallert, H., Yao, C., Shah, S., McRae, A.F., Lin, H., Horvath, S., Fallin, D., Hofman, A., Wareham, N.J., Wiggins, K.L., Feinberg, A.P., Starr, J.M., Visscher, P.M., Murabito, J.M., Kardia, S.L.R., Absher, D.M., Binder, E.B., Singleton, A.B., Bandinelli, S., Peters, A., Waldenberger, M., Matullo, G., Schwartz, J.D., Demerath, E.W., Uitterlinden, A.G., van Meurs, J.B.J., Franco, O.H., Chen, Y.-D.I., Levy, D., Turner, S.T., Deary, I.J., Ressler, K.J., Dupuis, J., Ferrucci, L., Ong, K.K., Assimes, T.L., Boerwinkle, E., Koenig, W., Arnett, D.K., Baccarelli, A.A., Benjamin, E.J., Dehghan, A., 2016. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 17, 255. doi.org/10.1186/s13059-016-1119-5

Lodrini, M., Poschmann, G., Schmidt, V., Wünschel, J., Dreidax, D., Witt, O., Höfer, T., Meyer, H.E., Stühler, K., Eggert, A., Deubzer, H.E., 2016. Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells. J. Proteome Res. 15, 2178–2186. doi.org/10.1021/acs.jproteome.6b00134

Loley, C., Alver, M., Assimes, T.L., Bjonnes, A., Goel, A., Gustafsson, S., Hernesniemi, J., Hopewell, J.C., Kanoni, S., Kleber, M.E., Lau, K.W., Lu, Y., Lyytikäinen, L.-P., Nelson, C.P., Nikpay, M., Qu, L., Salfati, E., Scholz, M., Tukiainen, T., Willenborg, C., Won, H.-H., Zeng, L., Zhang, W., Anand, S.S., Beutner, F., Bottinger, E.P., Clarke, R., Dedoussis, G., Do, R., Esko, T., Eskola, M., Farrall, M., Gauguier, D., Giedraitis, V., Granger, C.B., Hall, A.S., Hamsten, A., Hazen, S.L., Huang, J., Kähönen, M., Kyriakou, T., Laaksonen, R., Lind, L., Lindgren, C., Magnusson, P.K.E., Marouli, E., Mihailov, E., Morris, A.P., Nikus, K., Pedersen, N., Rallidis, L., Salomaa, V., Shah, S.H., Stewart, A.F.R., Thompson, J.R., Zalloua, P.A., Chambers, J.C., Collins, R., Ingelsson, E., Iribarren, C., Karhunen, P.J., Kooner, J.S., Lehtimäki, T., Loos, R.J.F., März, W., McPherson, R., Metspalu, A., Reilly, M.P., Ripatti, S., Sanghera, D.K., Thiery, J., Watkins, H., Deloukas, P., Kathiresan, S., Samani, N.J., Schunkert, H., Erdmann, J., König, I.R., 2016. No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Sci Rep 6, 35278. doi.org/10.1038/srep35278

Lorenzin, F., Benary, U., Baluapuri, A., Walz, S., Jung, L.A., Eyss, B. von, Kisker, C., Wolf, J., Eilers, M., Wolf, E., 2016. Different promoter affinities account for specificity in MYC-dependent gene regulation. eLife 5, e15161. doi.org/10.7554/eLife.15161

Ly, A., Buck, A., Balluff, B., Sun, N., Gorzolka, K., Feuchtinger, A., Janssen, K.-P., Kuppen, P.J.K., van de Velde, C.J.H., Weirich, G., Erlmeier, F., Langer, R., Aubele, M., Zitzelsberger, H., McDonnell, L., Aichler, M., Walch, A., 2016. High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue. Nat Protoc 11, 1428–1443. doi.org/10.1038/nprot.2016.081

Malik, R., Traylor, M., Pulit, S.L., Bevan, S., Hopewell, J.C., Holliday, E.G., Zhao, W., Abrantes, P., Amouyel, P., Attia, J.R., Battey, T.W.K., Berger, K., Boncoraglio, G.B., Chauhan, G., Cheng, Y.-C., Chen, W.-M., Clarke, R., Cotlarciuc, I., Debette, S., Falcone, G.J., Ferro, J.M., Gamble, D.M., Ilinca, A., Kittner, S.J., Kourkoulis, C.E., Lemmens, R., Levi, C.R., Lichtner, P., Lindgren, A., Liu, J., Meschia, J.F., Mitchell, B.D., Oliveira, S.A., Pera, J., Reiner, A.P., Rothwell, P.M., Sharma, P., Slowik, A., Sudlow, C.L.M., Tatlisumak, T., Thijs, V., Vicente, A.M., Woo, D., Seshadri, S., Saleheen, D., Rosand, J., Markus, H.S., Worrall, B.B., Dichgans, M., ISGC Analysis Group, METASTROKE collaboration, Wellcome Trust Case Control Consortium 2 (WTCCC2), NINDS Stroke Genetics Network (SiGN), 2016. Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology 86, 1217–1226. doi.org/10.1212/WNL.0000000000002528

Manz, J., Rodríguez, E., ElSharawy, A., Oesau, E.-M., Petersen, B.-S., Baurecht, H., Mayr, G., Weber, S., Harder, J., Reischl, E., Schwarz, A., Novak, N., Franke, A., Weidinger, S., 2016. Targeted Resequencing and Functional Testing Identifies Low-Frequency Missense Variants in the Gene Encoding GARP as Significant Contributors to Atopic Dermatitis Risk. J. Invest. Dermatol. 136, 2380–2386. doi.org/10.1016/j.jid.2016.07.009

Marzi, C., Holdt, L.M., Fiorito, G., Tsai, P.-C., Kretschmer, A., Wahl, S., Guarrera, S., Teupser, D., Spector, T.D., Iacoviello, L., Sacerdote, C., Strauch, K., Lee, S., Thasler, W.E., Peters, A., Thorand, B., Wolf, P., Prokisch, H., Tumino, R., Gieger, C., Krogh, V., Panico, S., Bell, J.T., Matullo, G., Waldenberger, M., Grallert, H., Koenig, W., 2016. Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues. PLoS ONE 11, e0166015. doi.org/10.1371/journal.pone.0166015

Meder, L., König, K., Ozretić, L., Schultheis, A.M., Ueckeroth, F., Ade, C.P., Albus, K., Boehm, D., Rommerscheidt-Fuss, U., Florin, A., Buhl, T., Hartmann, W., Wolf, J., Merkelbach-Bruse, S., Eilers, M., Perner, S., Heukamp, L.C., Buettner, R., 2016. NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas. Int. J. Cancer 138, 927–938. doi.org/10.1002/ijc.29835

Meier, S.M., Agerbo, E., Maier, R., Pedersen, C.B., Lang, M., Grove, J., Hollegaard, M.V., Demontis, D., Trabjerg, B.B., Hjorthøj, C., Ripke, S., Degenhardt, F., Nöthen, M.M., Rujescu, D., Maier, W., MooDS SCZ Consortium, Werge, T., Mors, O., Hougaard, D.M., Børglum, A.D., Wray, N.R., Rietschel, M., Nordentoft, M., Mortensen, P.B., Mattheisen, M., 2016. High loading of polygenic risk in cases with chronic schizophrenia. Mol. Psychiatry 21, 969–974. doi.org/10.1038/mp.2015.130

Messer, M., Schneider, G., 2016. The shark fin function: asymptotic behavior of the filtered derivative for point processes in case of change points. Stat Inference Stoch Process 1–20. doi.org/10.1007/s11203-016-9138-0

Mitchell, J.S., Li, N., Weinhold, N., Försti, A., Ali, M., van Duin, M., Thorleifsson, G., Johnson, D.C., Chen, B., Halvarsson, B.-M., Gudbjartsson, D.F., Kuiper, R., Stephens, O.W., Bertsch, U., Broderick, P., Campo, C., Einsele, H., Gregory, W.A., Gullberg, U., Henrion, M., Hillengass, J., Hoffmann, P., Jackson, G.H., Johnsson, E., Jöud, M., Kristinsson, S.Y., Lenhoff, S., Lenive, O., Mellqvist, U.-H., Migliorini, G., Nahi, H., Nelander, S., Nickel, J., Nöthen, M.M., Rafnar, T., Ross, F.M., da Silva Filho, M.I., Swaminathan, B., Thomsen, H., Turesson, I., Vangsted, A., Vogel, U., Waage, A., Walker, B.A., Wihlborg, A.-K., Broyl, A., Davies, F.E., Thorsteinsdottir, U., Langer, C., Hansson, M., Kaiser, M., Sonneveld, P., Stefansson, K., Morgan, G.J., Goldschmidt, H., Hemminki, K., Nilsson, B., Houlston, R.S., 2016. Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Nat Commun 7, 12050. doi.org/10.1038/ncomms12050

Mohnke, S., Erk, S., Schnell, K., Romanczuk-Seiferth, N., Schmierer, P., Romund, L., Garbusow, M., Wackerhagen, C., Ripke, S., Grimm, O., Haller, L., Witt, S.H., Degenhardt, F., Tost, H., Heinz, A., Meyer-Lindenberg, A., Walter, H., 2016. Theory of mind network activity is altered in subjects with familial liability for schizophrenia. Soc Cogn Affect Neurosci 11, 299–307. doi.org/10.1093/scan/nsv111

Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, 2016. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N. Engl. J. Med. 374, 1134–1144. doi.org/10.1056/NEJMoa1507652

Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC), 2016. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol 15, 695–707. doi.org/10.1016/S1474-4422(16)00102-2

Niessner, H., Schmitz, J., Tabatabai, G., Schmid, A.M., Calaminus, C., Sinnberg, T., Weide, B., Eigentler, T.K., Garbe, C., Schittek, B., Quintanilla-Fend, L., Bender, B., Mai, M., Praetorius, C., Beissert, S., Schackert, G., Muders, M.H., Meinhardt, M., Baretton, G.B., Dummer, R., Flaherty, K., Pichler, B.J., Kulms, D., Westphal, D., Meier, F., 2016. PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo. Clin. Cancer Res. 22, 5818–5828. doi.org/10.1158/1078-0432.CCR-16-0064

NINDS Stroke Genetics Network (SiGN, International Stroke Genetics Consortium (ISGC), 2016. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. The Lancet Neurology 15, 174–184. doi.org/10.1016/S1474-4422(15)00338-5

Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel, V., Klaus, B., Nadler, W., Rösli, C., Lutz, C., Kulke, M., Engelhardt, J., Zickgraf, F.M., Espinosa, O., Schlesner, M., Jiang, X., Kopp-Schneider, A., Neuhaus, P., Bahra, M., Sinn, B.V., Eils, R., Giese, N.A., Hackert, T., Strobel, O., Werner, J., Büchler, M.W., Weichert, W., Trumpp, A., Sprick, M.R., 2016. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nat. Med. 22, 278–287. doi.org/10.1038/nm.4038

Noori, H.R., Cosa Linan, A., Spanagel, R., 2016. Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis. Eur Neuropsychopharmacol 26, 1419–1430. doi.org/10.1016/j.euroneuro.2016.06.013

Ojeda, F.M., Müller, C., Börnigen, D., Trégouët, D.-A., Schillert, A., Heinig, M., Zeller, T., Schnabel, R.B., 2016. Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events. Genomics Proteomics Bioinformatics 14, 235–243. doi.org/10.1016/j.gpb.2016.03.006

Ortiz-Cuaran, S., Scheffler, M., Plenker, D., Dahmen, L., Scheel, A.H., Fernandez-Cuesta, L., Meder, L., Lovly, C.M., Persigehl, T., Merkelbach-Bruse, S., Bos, M., Michels, S., Fischer, R., Albus, K., König, K., Schildhaus, H.-U., Fassunke, J., Ihle, M.A., Pasternack, H., Heydt, C., Becker, C., Altmüller, J., Ji, H., Müller, C., Florin, A., Heuckmann, J.M., Nuernberg, P., Ansén, S., Heukamp, L.C., Berg, J., Pao, W., Peifer, M., Buettner, R., Wolf, J., Thomas, R.K., Sos, M.L., 2016. Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors. Clin. Cancer Res. 22, 4837–4847. doi.org/10.1158/1078-0432.CCR-15-1915

Parameswarappa, S.G., Reppe, K., Geissner, A., Ménová, P., Govindan, S., Calow, A.D.J., Wahlbrink, A., Weishaupt, M.W., Monnanda, B.P., Bell, R.L., Pirofski, L.-A., Suttorp, N., Sander, L.E., Witzenrath, M., Pereira, C.L., Anish, C., Seeberger, P.H., 2016. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection. Cell Chem Biol 23, 1407–1416. doi.org/10.1016/j.chembiol.2016.09.016

Poos, A.M., Maicher, A., Dieckmann, A.K., Oswald, M., Eils, R., Kupiec, M., Luke, B., König, R., 2016. Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast. Nucleic Acids Res. doi.org/10.1093/nar/gkw111

Poschke, I., Faryna, M., Bergmann, F., Flossdorf, M., Lauenstein, C., Hermes, J., Hinz, U., Hank, T., Ehrenberg, R., Volkmar, M., Loewer, M., Glimm, H., Hackert, T., Sprick, M.R., Höfer, T., Trumpp, A., Halama, N., Hassel, J.C., Strobel, O., Büchler, M., Sahin, U., Offringa, R., 2016a. Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma. OncoImmunology 5, e1240859. doi.org/10.1080/2162402X.2016.1240859

Poschke, I., Flossdorf, M., Offringa, R., 2016b. Next-generation TCR sequencing - a tool to understand T-cell infiltration in human cancers. J. Pathol. 240, 384–386. doi.org/10.1002/path.4800

Qin, W.-J., Wang, Y.-T., Li, P.-M., Wang, X.-X., Li, J.-X., Noori, H.R., Bernardi, R.E., Liang, J.-H., Zhang, X.-L., 2016. Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice. Psychopharmacology (Berl.) 233, 1147–1155. doi.org/10.1007/s00213-015-4197-2

Radi, M., Schneider, R., Fallacara, A.L., Botta, L., Crespan, E., Tintori, C., Maga, G., Kissova, M., Calgani, A., Richters, A., Musumeci, F., Rauh, D., Schenone, S., 2016. A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. Bioorg. Med. Chem. Lett. 26, 3436–3440. doi.org/10.1016/j.bmcl.2016.06.051

Ranganath, A., Jacob, S.N., 2016. Doping the Mind: Dopaminergic Modulation of Prefrontal Cortical Cognition. Neuroscientist 22, 593–603. doi.org/10.1177/1073858415602850

Rehimi, R., Nikolic, M., Cruz-Molina, S., Tebartz, C., Frommolt, P., Mahabir, E., Clément-Ziza, M., Rada-Iglesias, A., 2016. Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations. Cell Rep 17, 3062–3076. doi.org/10.1016/j.celrep.2016.11.046

Ribeiro, D., Klarqvist, M.D.R., Westermark, U.K., Oliynyk, G., Dzieran, J., Kock, A., Savatier Banares, C., Hertwig, F., Johnsen, J.I., Fischer, M., Kogner, P., Lovén, J., Arsenian Henriksson, M., 2016. Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients. Cell Rep 16, 979–993. doi.org/10.1016/j.celrep.2016.06.052

Rietschel, L., Streit, F., Zhu, G., McAloney, K., Kirschbaum, C., Frank, J., Hansell, N.K., Wright, M.J., McGrath, J.J., Witt, S.H., Rietschel, M., Martin, N.G., 2016. Hair Cortisol and Its Association With Psychological Risk Factors for Psychiatric Disorders: A Pilot Study in Adolescent Twins. Twin Res Hum Genet 19, 438–446. doi.org/10.1017/thg.2016.50

Rivera, N.V., Ronninger, M., Shchetynsky, K., Franke, A., Nöthen, M.M., Müller-Quernheim, J., Schreiber, S., Adrianto, I., Karakaya, B., van Moorsel, C.H.M., Navratilova, Z., Kolek, V., Rybicki, B.A., Iannuzzi, M.C., Petrek, M., Grutters, J.C., Montgomery, C., Fischer, A., Eklund, A., Padyukov, L., Grunewald, J., 2016. High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences. Am. J. Respir. Crit. Care Med. 193, 1008–1022. doi.org/10.1164/rccm.201507-1372OC

Santos, G., Nikolov, S., Lai, X., Eberhardt, M., Dreyer, F.S., Paul, S., Schuler, G., Vera, J., 2016. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis. Sci Rep 6, 24967. doi.org/10.1038/srep24967

Scheid, L.-M., Mosqueira, M., Hein, S., Kossack, M., Juergensen, L., Mueller, M., Meder, B., Fink, R.H.A., Katus, H.A., Hassel, D., 2016. Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress. Cardiovasc. Res. 111, 44–55. doi.org/10.1093/cvr/cvw066

Schepp, J., Bulashevska, A., Mannhardt-Laakmann, W., Cao, H., Yang, F., Seidl, M., Kelly, S., Hershfield, M., Grimbacher, B., 2016. Deficiency of Adenosine Deaminase 2 Causes Antibody Deficiency. J. Clin. Immunol. 36, 179–186. doi.org/10.1007/s10875-016-0245-x

Schirm, S., Ahnert, P., Wienhold, S., Mueller-Redetzky, H., Nouailles-Kursar, G., Loeffler, M., Witzenrath, M., Scholz, M., 2016. A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice. PLoS ONE 11, e0156047. doi.org/10.1371/journal.pone.0156047

Schmack, K., Burk, J., Haynes, J.-D., Sterzer, P., 2016a. Predicting Subjective Affective Salience from Cortical Responses to Invisible Object Stimuli. Cereb. Cortex 26, 3453–3460. doi.org/10.1093/cercor/bhv174

Schmack, K., Weilnhammer, V., Heinzle, J., Stephan, K.E., Sterzer, P., 2016b. Learning What to See in a Changing World. Front Hum Neurosci 10, 263. doi.org/10.3389/fnhum.2016.00263

Schmeck, B., Bertrams, W., Lai, X., Vera, J., 2016. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol. Biol. 1386, 119–133. doi.org/10.1007/978-1-4939-3283-2_8

Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Fölster-Holst, R., Rodríguez, E., Lee, Y.A.E., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nöthen, M.M., Irvine, A.D., McLean, W.H.I., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N., Weidinger, S., 2016. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J. Allergy Clin. Immunol. 137, 130–136. doi.org/10.1016/j.jaci.2015.06.029

Schneider, T., Hung, L.-H., Schreiner, S., Starke, S., Eckhof, H., Rossbach, O., Reich, S., Medenbach, J., Bindereif, A., 2016. CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Sci Rep 6, 31313. doi.org/10.1038/srep31313

Schoedel, K.B., Morcos, M.N.F., Zerjatke, T., Roeder, I., Grinenko, T., Voehringer, D., Göthert, J.R., Waskow, C., Roers, A., Gerbaulet, A., 2016. The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood. doi.org/10.1182/blood-2016-03-706010

Schreiner, F., Plamper, M., Dueker, G., Schoenberger, S., Gámez-Díaz, L., Grimbacher, B., Hilger, A.C., Gohlke, B., Reutter, H., Woelfle, J., 2016. Infancy-Onset T1DM, Short Stature, and Severe Immunodysregulation in Two Siblings With a Homozygous LRBA Mutation. J. Clin. Endocrinol. Metab. 101, 898–904. doi.org/10.1210/jc.2015-3382

Schwalb, B., Michel, M., Zacher, B., Frühauf, K., Demel, C., Tresch, A., Gagneur, J., Cramer, P., 2016. TT-seq maps the human transient transcriptome. Science 352, 1225–1228. doi.org/10.1126/science.aad9841

Schwantes-An, T.-H., Zhang, J., Chen, L.-S., Hartz, S.M., Culverhouse, R.C., Chen, X., Coon, H., Frank, J., Kamens, H.M., Konte, B., Kovanen, L., Latvala, A., Legrand, L.N., Maher, B.S., Melroy, W.E., Nelson, E.C., Reid, M.W., Robinson, J.D., Shen, P.-H., Yang, B.-Z., Andrews, J.A., Aveyard, P., Beltcheva, O., Brown, S.A., Cannon, D.S., Cichon, S., Corley, R.P., Dahmen, N., Degenhardt, L., Foroud, T., Gaebel, W., Giegling, I., Glatt, S.J., Grucza, R.A., Hardin, J., Hartmann, A.M., Heath, A.C., Herms, S., Hodgkinson, C.A., Hoffmann, P., Hops, H., Huizinga, D., Ising, M., Johnson, E.O., Johnstone, E., Kaneva, R.P., Kendler, K.S., Kiefer, F., Kranzler, H.R., Krauter, K.S., Levran, O., Lucae, S., Lynskey, M.T., Maier, W., Mann, K., Martin, N.G., Mattheisen, M., Montgomery, G.W., Müller-Myhsok, B., Murphy, M.F., Neale, M.C., Nikolov, M.A., Nishita, D., Nöthen, M.M., Nurnberger, J., Partonen, T., Pergadia, M.L., Reynolds, M., Ridinger, M., Rose, R.J., Rouvinen-Lagerström, N., Scherbaum, N., Schmäl, C., Soyka, M., Stallings, M.C., Steffens, M., Treutlein, J., Tsuang, M., Wall, T.L., Wodarz, N., Yuferov, V., Zill, P., Bergen, A.W., Chen, J., Cinciripini, P.M., Edenberg, H.J., Ehringer, M.A., Ferrell, R.E., Gelernter, J., Goldman, D., Hewitt, J.K., Hopfer, C.J., Iacono, W.G., Kaprio, J., Kreek, M.J., Kremensky, I.M., Madden, P.A.F., McGue, M., Munafò, M.R., Philibert, R.A., Rietschel, M., Roy, A., Rujescu, D., Saarikoski, S.T., Swan, G.E., Todorov, A.A., Vanyukov, M.M., Weiss, R.B., Bierut, L.J., Saccone, N.L., 2016. Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav. Genet. 46, 151–169. doi.org/10.1007/s10519-015-9737-3

Sharma, A.K., Eils, R., König, R., 2016. Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism. Cancer Res. 76, 4058–4067. doi.org/10.1158/0008-5472.CAN-15-2350

Siebert, M., Söding, J., 2016. Bayesian Markov models consistently outperform PWMs at predicting motifs in nucleotide sequences. Nucleic Acids Res. 44, 6055–6069. doi.org/10.1093/nar/gkw521

Simpkin, A.J., Hemani, G., Suderman, M., Gaunt, T.R., Lyttleton, O., Mcardle, W.L., Ring, S.M., Sharp, G.C., Tilling, K., Horvath, S., Kunze, S., Peters, A., Waldenberger, M., Ward-Caviness, C., Nohr, E.A., Sørensen, T.I.A., Relton, C.L., Smith, G.D., 2016. Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies. Hum. Mol. Genet. 25, 191–201. doi.org/10.1093/hmg/ddv456

Stacey, D., Lourdusamy, A., Ruggeri, B., Maroteaux, M., Jia, T., Cattrell, A., Nymberg, C., Banaschewski, T., Bhattacharyya, S., Band, H., Barker, G., Bokde, A., Buchel, C., Carvalho, F., Conrod, P., Desrivieres, S., Easton, A., Fauth-Buehler, M., Fernandez-Medarde, A., Flor, H., Frouin, V., Gallinat, J., Garavanh, H., Heinz, A., Ittermann, B., Lathrop, M., Lawrence, C., Loth, E., Mann, K., Martinot, J.-L., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Rotter, A., Santos, E., Smolka, M., Sommer, W., Mameli, M., Spanagel, R., Girault, J.-A., Mueller, C., Schumann, G., IMAGEN consortium, 2016. A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males. J Psychiatry Neurosci 41, 192–202. doi.org/10.1503/jpn.150138

Staufner, C., Haack, T.B., Köpke, M.G., Straub, B.K., Kölker, S., Thiel, C., Freisinger, P., Baric, I., McKiernan, P.J., Dikow, N., Harting, I., Beisse, F., Burgard, P., Kotzaeridou, U., Lenz, D., Kühr, J., Himbert, U., Taylor, R.W., Distelmaier, F., Vockley, J., Ghaloul-Gonzalez, L., Ozolek, J.A., Zschocke, J., Kuster, A., Dick, A., Das, A.M., Wieland, T., Terrile, C., Strom, T.M., Meitinger, T., Prokisch, H., Hoffmann, G.F., 2016. Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts. J. Inherit. Metab. Dis. 39, 3–16. doi.org/10.1007/s10545-015-9896-7

Streit, F., Memic, A., Hasandedić, L., Rietschel, L., Frank, J., Lang, M., Witt, S.H., Forstner, A.J., Degenhardt, F., Wüst, S., Nöthen, M.M., Kirschbaum, C., Strohmaier, J., Oruc, L., Rietschel, M., 2016. Perceived stress and hair cortisol: Differences in bipolar disorder and schizophrenia. Psychoneuroendocrinology 69, 26–34. doi.org/10.1016/j.psyneuen.2016.03.010

Stützer, A., Liokatis, S., Kiesel, A., Schwarzer, D., Sprangers, R., Söding, J., Selenko, P., Fischle, W., 2016. Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails. Mol. Cell 61, 247–259. doi.org/10.1016/j.molcel.2015.12.015

Syha, R., Grözinger, G., Grosse, U., Maurer, M., Zender, L., Horger, M., Nikolaou, K., Ketelsen, D., 2016. Parenchymal Blood Volume Assessed by C-Arm-Based Computed Tomography in Immediate Posttreatment Evaluation of Drug-Eluting Bead Transarterial Chemoembolization in Hepatocellular Carcinoma. Invest Radiol 51, 121–126. doi.org/10.1097/RLI.0000000000000215

Szczepanowski, M., Masqué-Soler, N., Schlesner, M., Haake, A., Richter, J., Wagener, R., Burkhardt, B., Kreuz, M., Siebert, R., ICGC MMML-Seq Consortium, Klapper, W., 2016. Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma. Haematologica 101, e259-261. doi.org/10.3324/haematol.2015.138701

Thaiss, W.M., Kaufmann, S., Kloth, C., Nikolaou, K., Bösmüller, H., Horger, M., 2016. VEGFR-2 expression in HCC, dysplastic and regenerative liver nodules, and correlation with pre-biopsy Dynamic Contrast Enhanced CT. Eur J Radiol 85, 2036–2041. doi.org/10.1016/j.ejrad.2016.09.012

Thiebes, S., Dehling, T., Sunyaev, A., 2016. One Size Does Not Fit All: Information Security and Information Privacy for Genomic Cloud Services (SSRN Scholarly Paper No. ID 2770946). Social Science Research Network, Rochester, NY.

Thompson, D., Vo, K.T., London, W.B., Fischer, M., Ambros, P.F., Nakagawara, A., Brodeur, G.M., Matthay, K.K., DuBois, S.G., 2016. Identification of patient subgroups with markedly disparate rates of MYCN amplification in neuroblastoma: A report from the International Neuroblastoma Risk Group project. Cancer 122, 935–945. doi.org/10.1002/cncr.29848

Uhrig, S., Hirth, N., Broccoli, L., von Wilmsdorff, M., Bauer, M., Sommer, C., Zink, M., Steiner, J., Frodl, T., Malchow, B., Falkai, P., Spanagel, R., Hansson, A.C., Schmitt, A., 2016. Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study. Schizophr. Res. 177, 59–66. doi.org/10.1016/j.schres.2016.04.019

Uribe-Mariño, A., Gassen, N.C., Wiesbeck, M.F., Balsevich, G., Santarelli, S., Solfrank, B., Dournes, C., Fries, G.R., Masana, M., Labermeier, C., Wang, X.-D., Hafner, K., Schmid, B., Rein, T., Chen, A., Deussing, J.M., Schmidt, M.V., 2016. Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 Conveys Acute Stress-Induced Executive Dysfunction. Biol. Psychiatry 80, 743–753. doi.org/10.1016/j.biopsych.2016.03.2106

Van der Auwera, S., Teumer, A., Hertel, J., Homuth, G., Völker, U., Lucht, M.J., Degenhardt, F., Schulze, T., Rietschel, M., Nöthen, M.M., John, U., Nauck, M., Grabe, H.J., 2016. The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl-D-aspartate) receptor activation via D-serine. Eur Neuropsychopharmacol 26, 1507–1515. doi.org/10.1016/j.euroneuro.2016.03.019

Vengeliene, V., Cannella, N., Takahashi, T., Spanagel, R., 2016a. Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse. Psychopharmacology (Berl.) 233, 3449–3459. doi.org/10.1007/s00213-016-4384-9

Vengeliene, V., Moeller, A., Meinhardt, M.W., Beardsley, P.M., Sommer, W.H., Spanagel, R., Bespalov, A., 2016b. The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile. Neuropsychopharmacology 41, 979–988. doi.org/10.1038/npp.2015.225

Vogt Weisenhorn, D.M., Giesert, F., Wurst, W., 2016. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson’s Disease. J. Neurochem. 139 Suppl 1, 8–26. doi.org/10.1111/jnc.13670

von der Heyde, S., Sonntag, J., Kramer, F., Bender, C., Korf, U., Beißbarth, T., 2016. Reconstruction of Protein Networks Using Reverse-Phase Protein Array Data. Methods Mol. Biol. 1362, 227–246. doi.org/10.1007/978-1-4939-3106-4_15

Wachter, A., Beißbarth, T., 2016. Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data. Front Genet 6, 351. doi.org/10.3389/fgene.2015.00351

Wallwiener, S., Strohmaier, J., Wallwiener, L.-M., Schönfisch, B., Zipfel, S., Brucker, S.Y., Rietschel, M., Wallwiener, C.W., 2016. Sexual Function Is Correlated With Body Image and Partnership Quality in Female University Students. J Sex Med 13, 1530–1538. doi.org/10.1016/j.jsxm.2016.07.020

Wang, J., Morita, Y., Han, B., Niemann, S., Löffler, B., Rudolph, K.L., 2016. Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Nat. Cell Biol. 18, 480–490. doi.org/10.1038/ncb3342

Wang, J., Thingholm, L.B., Skiecevičienė, J., Rausch, P., Kummen, M., Hov, J.R., Degenhardt, F., Heinsen, F.-A., Rühlemann, M.C., Szymczak, S., Holm, K., Esko, T., Sun, J., Pricop-Jeckstadt, M., Al-Dury, S., Bohov, P., Bethune, J., Sommer, F., Ellinghaus, D., Berge, R.K., Hübenthal, M., Koch, M., Schwarz, K., Rimbach, G., Hübbe, P., Pan, W.-H., Sheibani-Tezerji, R., Häsler, R., Rosenstiel, P., D’Amato, M., Cloppenborg-Schmidt, K., Künzel, S., Laudes, M., Marschall, H.-U., Lieb, W., Nöthlings, U., Karlsen, T.H., Baines, J.F., Franke, A., 2016. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nat. Genet. 48, 1396–1406. doi.org/10.1038/ng.3695

Weidinger, S., Rodríguez, E., Kabesch, M., 2016. Genetik und Epigenetik von allergischen Erkrankungen und Asthma, in: Biedermann, T., Heppt, W., Renz, H., Röcken, M. (Eds.), Allergologie. Springer Berlin Heidelberg, pp. 23–36. doi.org/10.1007/978-3-642-37203-2_3

Weinhold, N., Kirn, D., Seckinger, A., Hielscher, T., Granzow, M., Bertsch, U., Egerer, G., Salwender, H., Blau, I.W., Weisel, K., Hillengass, J., Raab, M.S., Hose, D., Goldschmidt, H., Jauch, A., 2016. Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma. Haematologica 101, e116-119. doi.org/10.3324/haematol.2015.136929

Weiskopf, K., Jahchan, N.S., Schnorr, P.J., Cristea, S., Ring, A.M., Maute, R.L., Volkmer, A.K., Volkmer, J.-P., Liu, J., Lim, J.S., Yang, D., Seitz, G., Nguyen, T., Wu, D., Jude, K., Guerston, H., Barkal, A., Trapani, F., George, J., Poirier, J.T., Gardner, E.E., Miles, L.A., de Stanchina, E., Lofgren, S.M., Vogel, H., Winslow, M.M., Dive, C., Thomas, R.K., Rudin, C.M., van de Rijn, M., Majeti, R., Garcia, K.C., Weissman, I.L., Sage, J., 2016. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J. Clin. Invest. 126, 2610–2620. doi.org/10.1172/JCI81603

Westerlind, H., Bonfiglio, F., Mellander, M.-R., Hìbenthal, M., Brynedal, B., Björk, J., Törkvist, L., Padyukov, L., Ohlsson, B., Löfberg, R., Hultcrantz, R., Franke, A., Bresso, F., D’Amato, M., 2016. HLA Associations Distinguish Collagenous From Lymphocytic Colitis. Am. J. Gastroenterol. 111, 1211–1213. doi.org/10.1038/ajg.2016.215

Wright, M.N., Ziegler, A., König, I.R., 2016. Do little interactions get lost in dark random forests? BMC Bioinformatics 17, 145. doi.org/10.1186/s12859-016-0995-8

Wüst, R., Maurer, B., Hauser, K., Woitalla, D., Sharma, M., Krüger, R., 2016. Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson’s disease. Neurobiol. Aging 39, 217.e13-15. doi.org/10.1016/j.neurobiolaging.2015.11.025

Zech, M., Boesch, S., Maier, E.M., Borggraefe, I., Vill, K., Laccone, F., Pilshofer, V., Ceballos-Baumann, A., Alhaddad, B., Berutti, R., Poewe, W., Haack, T.B., Haslinger, B., Strom, T.M., Winkelmann, J., 2016. Haploinsufficiency of KMT2B, Encoding the Lysine-Specific Histone Methyltransferase 2B, Results in Early-Onset Generalized Dystonia. Am. J. Hum. Genet. 99, 1377–1387. doi.org/10.1016/j.ajhg.2016.10.010

Zois, E., Vollstädt-Klein, S., Hoffmann, S., Reinhard, I., Bach, P., Charlet, K., Beck, A., Treutlein, J., Frank, J., Jorde, A., Kirsch, M., Degenhardt, F., Walter, H., Heinz, A., Kiefer, F., 2016. GATA4 variant interaction with brain limbic structure and relapse risk: A voxel-based morphometry study. Eur Neuropsychopharmacol 26, 1431–1437. doi.org/10.1016/j.euroneuro.2016.06.011

2015

Ahting, U., Mayr, J.A., Vanlander, A.V., Hardy, S.A., Santra, S., Makowski, C., Alston, C.L., Zimmermann, F.A., Abela, L., Plecko, B., Rohrbach, M., Spranger, S., Seneca, S., Rolinski, B., Hagendorff, A., Hempel, M., Sperl, W., Meitinger, T., Smet, J., Taylor, R.W., Van Coster, R., Freisinger, P., Prokisch, H., Haack, T.B., 2015. Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency. Front Genet 6, 123. doi.org/10.3389/fgene.2015.00123

Alva, V., Söding, J., Lupas, A.N., 2015. A vocabulary of ancient peptides at the origin of folded proteins. Elife 4, e09410. doi.org/10.7554/eLife.09410

Apou, G., Feuerhake, F., Forestier, G., Naegel, B., Wemmert, C., 2015. Synthesizing whole slide images, in: 2015 9th International Symposium on Image and Signal Processing and Analysis (ISPA). Presented at the 2015 9th International Symposium on Image and Signal Processing and Analysis (ISPA), pp. 154–159. doi.org/10.1109/ISPA.2015.7306050

Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K.V., Balsevich, G., Schmidt, M.V., Karbalai, N., Czamara, D., Altmann, A., Trümbach, D., Wurst, W., Mehta, D., Uhr, M., Klengel, T., Erhardt, A., Carey, C.E., Conley, E.D., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp, A., Müller-Myhsok, B., Hariri, A.R., Binder, E.B., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC, 2015. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron 86, 1189–1202. doi.org/10.1016/j.neuron.2015.05.034

Bach, P., Kirsch, M., Hoffmann, S., Jorde, A., Mann, K., Frank, J., Charlet, K., Beck, A., Heinz, A., Walter, H., Rietschel, M., Kiefer, F., Vollstädt-Klein, S., 2015a. The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving. Addict Biol 20, 1022–1032. doi.org/10.1111/adb.12291

Bach, P., Vollsta Dt-Klein, S., Kirsch, M., Hoffmann, S., Jorde, A., Frank, J., Charlet, K., Beck, A., Heinz, A., Walter, H., Sommer, W.H., Spanagel, R., Rietschel, M., Kiefer, F., 2015b. Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: a functional imaging study in alcohol dependent subjects. Eur Neuropsychopharmacol 25, 1128–1135. doi.org/10.1016/j.euroneuro.2015.04.013

Balluff, B., Frese, C.K., Maier, S.K., Schöne, C., Kuster, B., Schmitt, M., Aubele, M., Höfler, H., Deelder, A.M., Heck, A., Hogendoorn, P.C.W., Morreau, J., Maarten Altelaar, A.F., Walch, A., McDonnell, L.A., 2015. De novo discovery of phenotypic intratumour heterogeneity using imaging mass spectrometry. J. Pathol. 235, 3–13. doi.org/10.1002/path.4436

Basmanav, F.B., Forstner, A.J., Fier, H., Herms, S., Meier, S., Degenhardt, F., Hoffmann, P., Barth, S., Fricker, N., Strohmaier, J., Witt, S.H., Ludwig, M., Schmael, C., Moebus, S., Maier, W., Mössner, R., Rujescu, D., Rietschel, M., Lange, C., Nöthen, M.M., Cichon, S., 2015. Investigation of the role of TCF4 rare sequence variants in schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 168B, 354–362. doi.org/10.1002/ajmg.b.32318

Basu, D., Richters, A., Rauh, D., 2015. Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR. Bioorg. Med. Chem. 23, 2767–2780. doi.org/10.1016/j.bmc.2015.04.038

Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A.D., Kabesch, M., Lee, Y.A.E., Lieb, W., Marenholz, I., McLean, W.H.I., Morris, D.W., Mrowietz, U., Nair, R., Nöthen, M.M., Novak, N., O’Regan, G.M., Psoriasis Association Genetics Extension, Schreiber, S., Smith, C., Strauch, K., Stuart, P.E., Trembath, R., Tsoi, L.C., Weichenthal, M., Barker, J., Elder, J.T., Weidinger, S., Cordell, H.J., Brown, S.J., 2015. Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am. J. Hum. Genet. 96, 104–120. doi.org/10.1016/j.ajhg.2014.12.004

Bayerlová, M., Klemm, F., Kramer, F., Pukrop, T., Beißbarth, T., Bleckmann, A., 2015. Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. PLoS ONE 10, e0144014. doi.org/10.1371/journal.pone.0144014

Bender, J., Engeholm, M., Ederer, M.S., Breu, J., Møller, T.C., Michalakis, S., Rasko, T., Wanker, E.E., Biel, M., Martinez, K.L., Wurst, W., Deussing, J.M., 2015. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PLoS ONE 10, e0136768. doi.org/10.1371/journal.pone.0136768

Bernardi, R.E., Broccoli, L., Spanagel, R., Hansson, A.C., 2015. Sex differences in dopamine binding and modafinil conditioned place preference in mice. Drug Alcohol Depend 155, 37–44. doi.org/10.1016/j.drugalcdep.2015.08.016

Bilbao, A., Robinson, J.E., Heilig, M., Malanga, C.J., Spanagel, R., Sommer, W.H., Thorsell, A., 2015. A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. Biol. Psychiatry 77, 850–858. doi.org/10.1016/j.biopsych.2014.08.021

Binder, S.C., Hernandez-Vargas, E.A., Meyer-Hermann, M., 2015. Reducing complexity: An iterative strategy for parameter determination in biological networks. Computer Physics Communications 190, 15–22. doi.org/10.1016/j.cpc.2015.01.001

Boianelli, A., Nguyen, V.K., Ebensen, T., Schulze, K., Wilk, E., Sharma, N., Stegemann-Koniszewski, S., Bruder, D., Toapanta, F.R., Guzmán, C.A., Meyer-Hermann, M., Hernandez-Vargas, E.A., 2015. Modeling Influenza Virus Infection: A Roadmap for Influenza Research. Viruses 7, 5274–5304. doi.org/10.3390/v7102875

Bolomsky, A., Hose, D., Schreder, M., Seckinger, A., Lipp, S., Klein, B., Heintel, D., Ludwig, H., Zojer, N., 2015. Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma. J Hematol Oncol 8, 10. doi.org/10.1186/s13045-014-0105-1

Brænne, I., Civelek, M., Vilne, B., Di Narzo, A., Johnson, A.D., Zhao, Y., Reiz, B., Codoni, V., Webb, T.R., Foroughi Asl, H., Hamby, S.E., Zeng, L., Trégouët, D.-A., Hao, K., Topol, E.J., Schadt, E.E., Yang, X., Samani, N.J., Björkegren, J.L.M., Erdmann, J., Schunkert, H., Lusis, A.J., Leducq Consortium CAD Genomics‡, 2015. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler. Thromb. Vasc. Biol. 35, 2207–2217. doi.org/10.1161/ATVBAHA.115.306108

Brandenburg, V.M., Kleber, M.E., Vervloet, M.G., Larsson, T.E., Tomaschitz, A., Pilz, S., Stojakovic, T., Delgado, G., Grammer, T.B., Marx, N., März, W., Scharnagl, H., 2015. Soluble klotho and mortality: the Ludwigshafen Risk and Cardiovascular Health Study. Atherosclerosis 242, 483–489. doi.org/10.1016/j.atherosclerosis.2015.08.017

Brennand, K.J., Marchetto, M.C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J.C., Kaykas, A., Lancaster, M.A., Livesey, F.J., McConnell, M.J., McKay, R.D., Morrow, E.M., Muotri, A.R., Panchision, D.M., Rubin, L.L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, F.M., Wu, J., Vanderhaeghen, P., Gage, F.H., Jaenisch, R., 2015. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports 5, 933–945. doi.org/10.1016/j.stemcr.2015.10.011

Buch, S., Stickel, F., Trépo, E., Way, M., Herrmann, A., Nischalke, H.D., Brosch, M., Rosendahl, J., Berg, T., Ridinger, M., Rietschel, M., McQuillin, A., Frank, J., Kiefer, F., Schreiber, S., Lieb, W., Soyka, M., Semmo, N., Aigner, E., Datz, C., Schmelz, R., Brückner, S., Zeissig, S., Stephan, A.-M., Wodarz, N., Devière, J., Clumeck, N., Sarrazin, C., Lammert, F., Gustot, T., Deltenre, P., Völzke, H., Lerch, M.M., Mayerle, J., Eyer, F., Schafmayer, C., Cichon, S., Nöthen, M.M., Nothnagel, M., Ellinghaus, D., Huse, K., Franke, A., Zopf, S., Hellerbrand, C., Moreno, C., Franchimont, D., Morgan, M.Y., Hampe, J., 2015. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat. Genet. 47, 1443–1448. doi.org/10.1038/ng.3417

Buck, A., Ly, A., Balluff, B., Sun, N., Gorzolka, K., Feuchtinger, A., Janssen, K.-P., Kuppen, P.J.K., van de Velde, C.J.H., Weirich, G., Erlmeier, F., Langer, R., Aubele, M., Zitzelsberger, H., Aichler, M., Walch, A., 2015. High-resolution MALDI-FT-ICR MS imaging for the analysis of metabolites from formalin-fixed, paraffin-embedded clinical tissue samples. J. Pathol. 237, 123–132. doi.org/10.1002/path.4560

Carter, D.R., Murray, J., Cheung, B.B., Gamble, L., Koach, J., Tsang, J., Sutton, S., Kalla, H., Syed, S., Gifford, A.J., Issaeva, N., Biktasova, A., Atmadibrata, B., Sun, Y., Sokolowski, N., Ling, D., Kim, P.Y., Webber, H., Clark, A., Ruhle, M., Liu, B., Oberthuer, A., Fischer, M., Byrne, J., Saletta, F., Thwe, L.M., Purmal, A., Haderski, G., Burkhart, C., Speleman, F., De Preter, K., Beckers, A., Ziegler, D.S., Liu, T., Gurova, K.V., Gudkov, A.V., Norris, M.D., Haber, M., Marshall, G.M., 2015. Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma. Sci Transl Med 7, 312ra176. doi.org/10.1126/scitranslmed.aab1803

Cowan, G., Weston-Bell, N.J., Bryant, D., Seckinger, A., Hose, D., Zojer, N., Sahota, S.S., 2015. Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma. Oncotarget 6, 13229–13240. doi.org/10.18632/oncotarget.3644

Cury, C., Toro, R., Cohen, F., Fischer, C., Mhaya, A., Samper-González, J., Hasboun, D., Mangin, J.-F., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Buechel, C., Cattrell, A., Conrod, P., Flor, H., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaitre, H., Martinot, J.-L., Nees, F., Paillère Martinot, M.-L., Orfanos, D.P., Paus, T., Poustka, L., Smolka, M.N., Walter, H., Whelan, R., Frouin, V., Schumann, G., Glaunès, J.A., Colliot, O., IMAGEN Consortium, 2015. Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects. Front Neuroanat 9, 160. doi.org/10.3389/fnana.2015.00160

Dannlowski, U., Kugel, H., Grotegerd, D., Redlich, R., Suchy, J., Opel, N., Suslow, T., Konrad, C., Ohrmann, P., Bauer, J., Kircher, T., Krug, A., Jansen, A., Baune, B.T., Heindel, W., Domschke, K., Forstner, A.J., Nöthen, M.M., Treutlein, J., Arolt, V., Hohoff, C., Rietschel, M., Witt, S.H., 2015. NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray Matter Deficits in Healthy Subjects and Major Depression. Neuropsychopharmacology 40, 2510–2516. doi.org/10.1038/npp.2015.86

Dehling, T., Gao, F., Schneider, S., Sunyaev, A., 2015. Exploring the Far Side of Mobile Health: Information Security and Privacy of Mobile Health Apps on iOS and Android. JMIR mHealth and uHealth 3, e8. doi.org/10.2196/mhealth.3672

Desrivières, S., Lourdusamy, A., Tao, C., Toro, R., Jia, T., Loth, E., Medina, L.M., Kepa, A., Fernandes, A., Ruggeri, B., Carvalho, F.M., Cocks, G., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Büchel, C., Conrod, P.J., Flor, H., Heinz, A., Gallinat, J., Garavan, H., Gowland, P., Brühl, R., Lawrence, C., Mann, K., Martinot, M.L.P., Nees, F., Lathrop, M., Poline, J.-B., Rietschel, M., Thompson, P., Fauth-Bühler, M., Smolka, M.N., Pausova, Z., Paus, T., Feng, J., Schumann, G., IMAGEN Consortium, 2015. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Mol. Psychiatry 20, 263–274. doi.org/10.1038/mp.2013.197

Dietlein, F., Kalb, B., Jokic, M., Noll, E.M., Strong, A., Tharun, L., Ozretić, L., Künstlinger, H., Kambartel, K., Randerath, W.J., Jüngst, C., Schmitt, A., Torgovnick, A., Richters, A., Rauh, D., Siedek, F., Persigehl, T., Mauch, C., Bartkova, J., Bradley, A., Sprick, M.R., Trumpp, A., Rad, R., Saur, D., Bartek, J., Wolf, J., Büttner, R., Thomas, R.K., Reinhardt, H.C., 2015. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Cell 162, 146–159. doi.org/10.1016/j.cell.2015.05.053

Do, K.T., Kastenmüller, G., Mook-Kanamori, D.O., Yousri, N.A., Theis, F.J., Suhre, K., Krumsiek, J., 2015. Network-based approach for analyzing intra- and interfluid metabolite associations in human blood, urine, and saliva. J. Proteome Res. 14, 1183–1194. doi.org/10.1021/pr501130a

Eisenhardt, M., Hansson, A.C., Spanagel, R., Bilbao, A., 2015a. Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling. Alcohol. Clin. Exp. Res. 39, 752–762. doi.org/10.1111/acer.12686

Eisenhardt, M., Leixner, S., Luján, R., Spanagel, R., Bilbao, A., 2015b. Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior. J. Neurosci. 35, 15523–15538. doi.org/10.1523/JNEUROSCI.2970-15.2015

Eisenhardt, M., Leixner, S., Spanagel, R., Bilbao, A., 2015c. Quantification of alcohol drinking patterns in mice. Addict Biol 20, 1001–1011. doi.org/10.1111/adb.12325

Engel, J., Richters, A., Getlik, M., Tomassi, S., Keul, M., Termathe, M., Lategahn, J., Becker, C., Mayer-Wrangowski, S., Grütter, C., Uhlenbrock, N., Krüll, J., Schaumann, N., Eppmann, S., Kibies, P., Hoffgaard, F., Heil, J., Menninger, S., Ortiz-Cuaran, S., Heuckmann, J.M., Tinnefeld, V., Zahedi, R.P., Sos, M.L., Schultz-Fademrecht, C., Thomas, R.K., Kast, S.M., Rauh, D., 2015. Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J. Med. Chem. 58, 6844–6863. doi.org/10.1021/acs.jmedchem.5b01082

Engelhardt, S., Sassi, Y., 2015. MicroRNA Augmentation of Bone Marrow-Derived Cell Therapy. J. Am. Coll. Cardiol. 66, 2227–2229. doi.org/10.1016/j.jacc.2015.09.053

Fang, Z., Simard, J.R., Plenker, D., Nguyen, H.D., Phan, T., Wolle, P., Baumeister, S., Rauh, D., 2015. Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. ACS Chem. Biol. 10, 279–288. doi.org/10.1021/cb500355c

Fernandez-Cuesta, L., Sun, R., Menon, R., George, J., Lorenz, S., Meza-Zepeda, L.A., Peifer, M., Plenker, D., Heuckmann, J.M., Leenders, F., Zander, T., Dahmen, I., Koker, M., Schöttle, J., Ullrich, R.T., Altmüller, J., Becker, C., Nürnberg, P., Seidel, H., Böhm, D., Göke, F., Ansén, S., Russell, P.A., Wright, G.M., Wainer, Z., Solomon, B., Petersen, I., Clement, J.H., Sänger, J., Brustugun, O.-T., Helland, Å., Solberg, S., Lund-Iversen, M., Buettner, R., Wolf, J., Brambilla, E., Vingron, M., Perner, S., Haas, S.A., Thomas, R.K., 2015. Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biol. 16, 7. doi.org/10.1186/s13059-014-0558-0

Feuchtinger, A., Stiehler, T., Jütting, U., Marjanovic, G., Luber, B., Langer, R., Walch, A., 2015. Image analysis of immunohistochemistry is superior to visual scoring as shown for patient outcome of esophageal adenocarcinoma. Histochem. Cell Biol. 143, 1–9. doi.org/10.1007/s00418-014-1258-2

Fey, D., Halasz, M., Dreidax, D., Kennedy, S.P., Hastings, J.F., Rauch, N., Munoz, A.G., Pilkington, R., Fischer, M., Westermann, F., Kolch, W., Kholodenko, B.N., Croucher, D.R., 2015. Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients. Sci Signal 8, ra130. doi.org/10.1126/scisignal.aab0990

Fichtner, S., Hose, D., Engelhardt, M., Meißner, T., Neuber, B., Krasniqi, F., Raab, M., Schönland, S., Ho, A.D., Goldschmidt, H., Hundemer, M., 2015. Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma. Clin. Cancer Res. 21, 1712–1721. doi.org/10.1158/1078-0432.CCR-14-1618

Fischer, A., Ellinghaus, D., Nutsua, M., Hofmann, S., Montgomery, C.G., Iannuzzi, M.C., Rybicki, B.A., Petrek, M., Mrazek, F., Pabst, S., Grohé, C., Grunewald, J., Ronninger, M., Eklund, A., Padyukov, L., Mihailovic-Vucinic, V., Jovanovic, D., Sterclova, M., Homolka, J., Nöthen, M.M., Herms, S., Gieger, C., Strauch, K., Winkelmann, J., Boehm, B.O., Brand, S., Büning, C., Schürmann, M., Ellinghaus, E., Baurecht, H., Lieb, W., Nebel, A., Müller-Quernheim, J., Franke, A., Schreiber, S., GenPhenReSa Consortium, 2015. Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk. Am. J. Respir. Crit. Care Med. 192, 727–736. doi.org/10.1164/rccm.201503-0418OC

Fliegauf, M., Bryant, V.L., Frede, N., Slade, C., Woon, S.-T., Lehnert, K., Winzer, S., Bulashevska, A., Scerri, T., Leung, E., Jordan, A., Keller, B., de Vries, E., Cao, H., Yang, F., Schäffer, A.A., Warnatz, K., Browett, P., Douglass, J., Ameratunga, R.V., van der Meer, J.W.M., Grimbacher, B., 2015. Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency. Am. J. Hum. Genet. 97, 389–403. doi.org/10.1016/j.ajhg.2015.07.008

Flossdorf, M., Rössler, J., Buchholz, V.R., Busch, D.H., Höfer, T., 2015. CD8(+) T cell diversification by asymmetric cell division. Nat. Immunol. 16, 891–893. doi.org/10.1038/ni.3235

Forstner, A.J., Hofmann, A., Maaser, A., Sumer, S., Khudayberdiev, S., Mühleisen, T.W., Leber, M., Schulze, T.G., Strohmaier, J., Degenhardt, F., Treutlein, J., Mattheisen, M., Schumacher, J., Breuer, R., Meier, S., Herms, S., Hoffmann, P., Lacour, A., Witt, S.H., Reif, A., Müller-Myhsok, B., Lucae, S., Maier, W., Schwarz, M., Vedder, H., Kammerer-Ciernioch, J., Pfennig, A., Bauer, M., Hautzinger, M., Moebus, S., Priebe, L., Sivalingam, S., Verhaert, A., Schulz, H., Czerski, P.M., Hauser, J., Lissowska, J., Szeszenia-Dabrowska, N., Brennan, P., McKay, J.D., Wright, A., Mitchell, P.B., Fullerton, J.M., Schofield, P.R., Montgomery, G.W., Medland, S.E., Gordon, S.D., Martin, N.G., Krasnov, V., Chuchalin, A., Babadjanova, G., Pantelejeva, G., Abramova, L.I., Tiganov, A.S., Polonikov, A., Khusnutdinova, E., Alda, M., Cruceanu, C., Rouleau, G.A., Turecki, G., Laprise, C., Rivas, F., Mayoral, F., Kogevinas, M., Grigoroiu-Serbanescu, M., Propping, P., Becker, T., Rietschel, M., Cichon, S., Schratt, G., Nöthen, M.M., 2015. Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder. Transl Psychiatry 5, e678. doi.org/10.1038/tp.2015.159

Frank, J., Lang, M., Witt, S.H., Strohmaier, J., Rujescu, D., Cichon, S., Degenhardt, F., Nöthen, M.M., Collier, D.A., Ripke, S., Naber, D., Rietschel, M., 2015. Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients. Mol. Psychiatry 20, 150–151. doi.org/10.1038/mp.2014.56

French, L., Gray, C., Leonard, G., Perron, M., Pike, G.B., Richer, L., Séguin, J.R., Veillette, S., Evans, C.J., Artiges, E., Banaschewski, T., Bokde, A.W.L., Bromberg, U., Bruehl, R., Buchel, C., Cattrell, A., Conrod, P.J., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Lemaitre, H., Martinot, J.-L., Nees, F., Orfanos, D.P., Pangelinan, M.M., Poustka, L., Rietschel, M., Smolka, M.N., Walter, H., Whelan, R., Timpson, N.J., Schumann, G., Smith, G.D., Pausova, Z., Paus, T., 2015. Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence. JAMA Psychiatry 72, 1002–1011. doi.org/10.1001/jamapsychiatry.2015.1131

Fritsch, V., Da Mota, B., Loth, E., Varoquaux, G., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Brühl, R., Butzek, B., Conrod, P., Flor, H., Garavan, H., Lemaitre, H., Mann, K., Nees, F., Paus, T., Schad, D.J., Schümann, G., Frouin, V., Poline, J.-B., Thirion, B., IMAGEN consortium, 2015. Robust regression for large-scale neuroimaging studies. Neuroimage 111, 431–441. doi.org/10.1016/j.neuroimage.2015.02.048

Gade, K., Malzahn, D., Anderson-Schmidt, H., Strohmaier, J., Meier, S., Frank, J., Falkai, P.G., Rietschel, M., Schulze, T.G., 2015. Functional outcome in major psychiatric disorders and associated clinical and psychosocial variables: A potential cross-diagnostic phenotype for further genetic investigations? World J. Biol. Psychiatry 16, 237–248. doi.org/10.3109/15622975.2014.995221

Gandara, D.R., Hammerman, P.S., Sos, M.L., Lara, P.N., Hirsch, F.R., 2015. Squamous cell lung cancer: from tumor genomics to cancer therapeutics. Clin. Cancer Res. 21, 2236–2243. doi.org/10.1158/1078-0432.CCR-14-3039

Ganzinger, M., Gietzelt, M., Karmen, C., Firnkorn, D., Knaup, P., 2015a. An IT Architecture for Systems Medicine. Stud Health Technol Inform 210, 185–189. doi.org/10.3233/978-1-61499-512-8-185

Ganzinger, M., Haux, C., Karmen, C., Wetter, T., Knaup, P., 2015b. Systems Medicine for Multiple Myeloma: A Review on Decision Support Systems. Stud Health Technol Inform 216, 951. doi.org/10.3233/978-1-61499-564-7-951

George, J., Lim, J.S., Jang, S.J., Cun, Y., Ozretić, L., Kong, G., Leenders, F., Lu, X., Fernández-Cuesta, L., Bosco, G., Müller, C., Dahmen, I., Jahchan, N.S., Park, K.-S., Yang, D., Karnezis, A.N., Vaka, D., Torres, A., Wang, M.S., Korbel, J.O., Menon, R., Chun, S.-M., Kim, D., Wilkerson, M., Hayes, N., Engelmann, D., Pützer, B., Bos, M., Michels, S., Vlasic, I., Seidel, D., Pinther, B., Schaub, P., Becker, C., Altmüller, J., Yokota, J., Kohno, T., Iwakawa, R., Tsuta, K., Noguchi, M., Muley, T., Hoffmann, H., Schnabel, P.A., Petersen, I., Chen, Y., Soltermann, A., Tischler, V., Choi, C., Kim, Y.-H., Massion, P.P., Zou, Y., Jovanovic, D., Kontic, M., Wright, G.M., Russell, P.A., Solomon, B., Koch, I., Lindner, M., Muscarella, L.A., la Torre, A., Field, J.K., Jakopovic, M., Knezevic, J., Castaños-Vélez, E., Roz, L., Pastorino, U., Brustugun, O.-T., Lund-Iversen, M., Thunnissen, E., Köhler, J., Schuler, M., Botling, J., Sandelin, M., Sanchez-Cespedes, M., Salvesen, H.B., Achter, V., Lang, U., Bogus, M., Schneider, P.M., Zander, T., Ansén, S., Hallek, M., Wolf, J., Vingron, M., Yatabe, Y., Travis, W.D., Nürnberg, P., Reinhardt, C., Perner, S., Heukamp, L., Büttner, R., Haas, S.A., Brambilla, E., Peifer, M., Sage, J., Thomas, R.K., 2015. Comprehensive genomic profiles of small cell lung cancer. Nature 524, 47–53. doi.org/10.1038/nature14664

Gorochov, G., Larsen, M., Parizot, C., Brisson, H., Nienen, M., Kuchenbecker, L., Babel, N., Neumann, A.U., 2015. Comment on “Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients.” Sci Transl Med 7, 297le1. doi.org/10.1126/scitranslmed.aab1994

Gorris, R., Fischer, J., Erwes, K.L., Kesavan, J., Peterson, D.A., Alexander, M., Nöthen, M.M., Peitz, M., Quandel, T., Karus, M., Brüstle, O., 2015. Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia 63, 2152–2167. doi.org/10.1002/glia.22882

Goyette, P., Boucher, G., Mallon, D., Ellinghaus, E., Jostins, L., Huang, H., Ripke, S., Gusareva, E.S., Annese, V., Hauser, S.L., Oksenberg, J.R., Thomsen, I., Leslie, S., International Inflammatory Bowel Disease Genetics Consortium, Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium, Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium, United Kingdom IBDGC, Wellcome Trust Case Control Consortium, Quebec IBD Genetics Consortium, Daly, M.J., Van Steen, K., Duerr, R.H., Barrett, J.C., McGovern, D.P.B., Schumm, L.P., Traherne, J.A., Carrington, M.N., Kosmoliaptsis, V., Karlsen, T.H., Franke, A., Rioux, J.D., 2015. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat. Genet. 47, 172–179. doi.org/10.1038/ng.3176

Haack, T.B., Jackson, C.B., Murayama, K., Kremer, L.S., Schaller, A., Kotzaeridou, U., de Vries, M.C., Schottmann, G., Santra, S., Büchner, B., Wieland, T., Graf, E., Freisinger, P., Eggimann, S., Ohtake, A., Okazaki, Y., Kohda, M., Kishita, Y., Tokuzawa, Y., Sauer, S., Memari, Y., Kolb-Kokocinski, A., Durbin, R., Hasselmann, O., Cremer, K., Albrecht, B., Wieczorek, D., Engels, H., Hahn, D., Zink, A.M., Alston, C.L., Taylor, R.W., Rodenburg, R.J., Trollmann, R., Sperl, W., Strom, T.M., Hoffmann, G.F., Mayr, J.A., Meitinger, T., Bolognini, R., Schuelke, M., Nuoffer, J.-M., Kölker, S., Prokisch, H., Klopstock, T., 2015a. Deficiency of ECHS1 causes mitochondrial encephalopathy with cardiac involvement. Ann Clin Transl Neurol 2, 492–509. doi.org/10.1002/acn3.189

Haack, T.B., Staufner, C., Köpke, M.G., Straub, B.K., Kölker, S., Thiel, C., Freisinger, P., Baric, I., McKiernan, P.J., Dikow, N., Harting, I., Beisse, F., Burgard, P., Kotzaeridou, U., Kühr, J., Himbert, U., Taylor, R.W., Distelmaier, F., Vockley, J., Ghaloul-Gonzalez, L., Zschocke, J., Kremer, L.S., Graf, E., Schwarzmayr, T., Bader, D.M., Gagneur, J., Wieland, T., Terrile, C., Strom, T.M., Meitinger, T., Hoffmann, G.F., Prokisch, H., 2015b. Biallelic Mutations in NBAS Cause Recurrent Acute Liver Failure with Onset in Infancy. Am. J. Hum. Genet. 97, 163–169. doi.org/10.1016/j.ajhg.2015.05.009

Hasenauer, J., Jagiella, N., Hross, S., Theis, F.J., 2015. Data-Driven Modelling of Biological Multi-Scale Processes. Journal of Coupled Systems and Multiscale Dynamics 3, 101–121. doi.org/10.1166/jcsmd.2015.1069

Hatzikirou, H., Alfonso, J.C.L., Mühle, S., Stern, C., Weiss, S., Meyer-Hermann, M., 2015. Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions. J R Soc Interface 12. doi.org/10.1098/rsif.2015.0439

Heilbronner, U., Malzahn, D., Strohmaier, J., Maier, S., Frank, J., Treutlein, J., Mühleisen, T.W., Forstner, A.J., Witt, S.H., Cichon, S., Falkai, P., Nöthen, M.M., Rietschel, M., Schulze, T.G., 2015. A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder. Eur Neuropsychopharmacol 25, 2262–2270. doi.org/10.1016/j.euroneuro.2015.09.012

Hein, S.J., Lehmann, L.H., Kossack, M., Juergensen, L., Fuchs, D., Katus, H.A., Hassel, D., 2015. Advanced echocardiography in adult zebrafish reveals delayed recovery of heart function after myocardial cryoinjury. PLoS ONE 10, e0122665. doi.org/10.1371/journal.pone.0122665

Heinz, A., Charlet, K., Rapp, M.A., 2015. Public mental health: a call to action. World Psychiatry 14, 49–50. doi.org/10.1002/wps.20182

Hempel, M., Cremer, K., Ockeloen, C.W., Lichtenbelt, K.D., Herkert, J.C., Denecke, J., Haack, T.B., Zink, A.M., Becker, J., Wohlleber, E., Johannsen, J., Alhaddad, B., Pfundt, R., Fuchs, S., Wieczorek, D., Strom, T.M., van Gassen, K.L.I., Kleefstra, T., Kubisch, C., Engels, H., Lessel, D., 2015. De Novo Mutations in CHAMP1 Cause Intellectual Disability with Severe Speech Impairment. Am. J. Hum. Genet. 97, 493–500. doi.org/10.1016/j.ajhg.2015.08.003

Hibar, D.P., Stein, J.L., Renteria, M.E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B.S., Armstrong, N.J., Bernard, M., Bohlken, M.M., Boks, M.P., Bralten, J., Brown, A.A., Chakravarty, M.M., Chen, Q., Ching, C.R.K., Cuellar-Partida, G., den Braber, A., Giddaluru, S., Goldman, A.L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A.J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P.H., Olde Loohuis, L.M., Luciano, M., Macare, C., Mather, K.A., Mattheisen, M., Milaneschi, Y., Nho, K., Papmeyer, M., Ramasamy, A., Risacher, S.L., Roiz-Santiañez, R., Rose, E.J., Salami, A., Sämann, P.G., Schmaal, L., Schork, A.J., Shin, J., Strike, L.T., Teumer, A., van Donkelaar, M.M.J., van Eijk, K.R., Walters, R.K., Westlye, L.T., Whelan, C.D., Winkler, A.M., Zwiers, M.P., Alhusaini, S., Athanasiu, L., Ehrlich, S., Hakobjan, M.M.H., Hartberg, C.B., Haukvik, U.K., Heister, A.J.G.A.M., Hoehn, D., Kasperaviciute, D., Liewald, D.C.M., Lopez, L.M., Makkinje, R.R.R., Matarin, M., Naber, M.A.M., McKay, D.R., Needham, M., Nugent, A.C., Pütz, B., Royle, N.A., Shen, L., Sprooten, E., Trabzuni, D., van der Marel, S.S.L., van Hulzen, K.J.E., Walton, E., Wolf, C., Almasy, L., Ames, D., Arepalli, S., Assareh, A.A., Bastin, M.E., Brodaty, H., Bulayeva, K.B., Carless, M.A., Cichon, S., Corvin, A., Curran, J.E., Czisch, M., de Zubicaray, G.I., Dillman, A., Duggirala, R., Dyer, T.D., Erk, S., Fedko, I.O., Ferrucci, L., Foroud, T.M., Fox, P.T., Fukunaga, M., Gibbs, J.R., Göring, H.H.H., Green, R.C., Guelfi, S., Hansell, N.K., Hartman, C.A., Hegenscheid, K., Heinz, A., Hernandez, D.G., Heslenfeld, D.J., Hoekstra, P.J., Holsboer, F., Homuth, G., Hottenga, J.-J., Ikeda, M., Jack, C.R., Jenkinson, M., Johnson, R., Kanai, R., Keil, M., Kent, J.W., Kochunov, P., Kwok, J.B., Lawrie, S.M., Liu, X., Longo, D.L., McMahon, K.L., Meisenzahl, E., Melle, I., Mohnke, S., Montgomery, G.W., Mostert, J.C., Mühleisen, T.W., Nalls, M.A., Nichols, T.E., Nilsson, L.G., Nöthen, M.M., Ohi, K., Olvera, R.L., Perez-Iglesias, R., Pike, G.B., Potkin, S.G., Reinvang, I., Reppermund, S., Rietschel, M., Romanczuk-Seiferth, N., Rosen, G.D., Rujescu, D., Schnell, K., Schofield, P.R., Smith, C., Steen, V.M., Sussmann, J.E., Thalamuthu, A., Toga, A.W., Traynor, B.J., Troncoso, J., Turner, J.A., Valdés Hernández, M.C., van ’t Ent, D., van der Brug, M., van der Wee, N.J.A., van Tol, M.-J., Veltman, D.J., Wassink, T.H., Westman, E., Zielke, R.H., Zonderman, A.B., Ashbrook, D.G., Hager, R., Lu, L., McMahon, F.J., Morris, D.W., Williams, R.W., Brunner, H.G., Buckner, R.L., Buitelaar, J.K., Cahn, W., Calhoun, V.D., Cavalleri, G.L., Crespo-Facorro, B., Dale, A.M., Davies, G.E., Delanty, N., Depondt, C., Djurovic, S., Drevets, W.C., Espeseth, T., Gollub, R.L., Ho, B.-C., Hoffmann, W., Hosten, N., Kahn, R.S., Le Hellard, S., Meyer-Lindenberg, A., Müller-Myhsok, B., Nauck, M., Nyberg, L., Pandolfo, M., Penninx, B.W.J.H., Roffman, J.L., Sisodiya, S.M., Smoller, J.W., van Bokhoven, H., van Haren, N.E.M., Völzke, H., Walter, H., Weiner, M.W., Wen, W., White, T., Agartz, I., Andreassen, O.A., Blangero, J., Boomsma, D.I., Brouwer, R.M., Cannon, D.M., Cookson, M.R., de Geus, E.J.C., Deary, I.J., Donohoe, G., Fernández, G., Fisher, S.E., Francks, C., Glahn, D.C., Grabe, H.J., Gruber, O., Hardy, J., Hashimoto, R., Hulshoff Pol, H.E., Jönsson, E.G., Kloszewska, I., Lovestone, S., Mattay, V.S., Mecocci, P., McDonald, C., McIntosh, A.M., Ophoff, R.A., Paus, T., Pausova, Z., Ryten, M., Sachdev, P.S., Saykin, A.J., Simmons, A., Singleton, A., Soininen, H., Wardlaw, J.M., Weale, M.E., Weinberger, D.R., Adams, H.H.H., Launer, L.J., Seiler, S., Schmidt, R., Chauhan, G., Satizabal, C.L., Becker, J.T., Yanek, L., van der Lee, S.J., Ebling, M., Fischl, B., Longstreth, W.T., Greve, D., Schmidt, H., Nyquist, P., Vinke, L.N., van Duijn, C.M., Xue, L., Mazoyer, B., Bis, J.C., Gudnason, V., Seshadri, S., Ikram, M.A., Alzheimer’s Disease Neuroimaging Initiative, CHARGE Consortium, EPIGEN, IMAGEN, SYS, Martin, N.G., Wright, M.J., Schumann, G., Franke, B., Thompson, P.M., Medland, S.E., 2015. Common genetic variants influence human subcortical brain structures. Nature 520, 224–229. doi.org/10.1038/nature14101

Hug, S., Schwarzfischer, M., Hasenauer, J., Marr, C., Theis, F.J., 2015. An adaptive scheduling scheme for calculating Bayes factors with thermodynamic integration using Simpson’s rule. Stat Comput 26, 663–677. doi.org/10.1007/s11222-015-9550-0

Ingold, I., Aichler, M., Yefremova, E., Roveri, A., Buday, K., Doll, S., Tasdemir, A., Hoffard, N., Wurst, W., Walch, A., Ursini, F., Friedmann Angeli, J.P., Conrad, M., 2015. Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility. J. Biol. Chem. 290, 14668–14678. doi.org/10.1074/jbc.M115.656363

Jansen, H., Loley, C., Lieb, W., Pencina, M.J., Nelson, C.P., Kathiresan, S., Peloso, G.M., Voight, B.F., Reilly, M.P., Assimes, T.L., Boerwinkle, E., Hengstenberg, C., Laaksonen, R., McPherson, R., Roberts, R., Thorsteinsdottir, U., Peters, A., Gieger, C., Rawal, R., Thompson, J.R., König, I.R., CARDIoGRAM consortium, Vasan, R.S., Erdmann, J., Samani, N.J., Schunkert, H., 2015a. Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis 241, 419–426. doi.org/10.1016/j.atherosclerosis.2015.05.033

Jansen, H., Willenborg, C., Schlesinger, S., Ferrario, P.G., König, I.R., Erdmann, J., Samani, N.J., Lieb, W., Schunkert, H., 2015b. Genetic variants associated with celiac disease and the risk for coronary artery disease. Mol. Genet. Genomics 290, 1911–1917. doi.org/10.1007/s00438-015-1045-3

Juraeva, D., Treutlein, J., Scholz, H., Frank, J., Degenhardt, F., Cichon, S., Ridinger, M., Mattheisen, M., Witt, S.H., Lang, M., Sommer, W.H., Hoffmann, P., Herms, S., Wodarz, N., Soyka, M., Zill, P., Maier, W., Jünger, E., Gaebel, W., Dahmen, N., Scherbaum, N., Schmäl, C., Steffens, M., Lucae, S., Ising, M., Smolka, M.N., Zimmermann, U.S., Müller-Myhsok, B., Nöthen, M.M., Mann, K., Kiefer, F., Spanagel, R., Brors, B., Rietschel, M., 2015. XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. Neuropsychopharmacology 40, 361–371. doi.org/10.1038/npp.2014.178

Kastenmüller, G., Raffler, J., Gieger, C., Suhre, K., 2015. Genetics of human metabolism: an update. Hum. Mol. Genet. 24, R93–R101. doi.org/10.1093/hmg/ddv263

Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., Kelly, T.N., Saleheen, D., Lehne, B., Mateo Leach, I., Drong, A.W., Abbott, J., Wahl, S., Tan, S.-T., Scott, W.R., Campanella, G., Chadeau-Hyam, M., Afzal, U., Ahluwalia, T.S., Bonder, M.J., Chen, P., Dehghan, A., Edwards, T.L., Esko, T., Go, M.J., Harris, S.E., Hartiala, J., Kasela, S., Kasturiratne, A., Khor, C.-C., Kleber, M.E., Li, H., Mok, Z.Y., Nakatochi, M., Sapari, N.S., Saxena, R., Stewart, A.F.R., Stolk, L., Tabara, Y., Teh, A.L., Wu, Y., Wu, J.-Y., Zhang, Y., Aits, I., Da Silva Couto Alves, A., Das, S., Dorajoo, R., Hopewell, J.C., Kim, Y.K., Koivula, R.W., Luan, J. ’an, Lyytikäinen, L.-P., Nguyen, Q.N., Pereira, M.A., Postmus, I., Raitakari, O.T., Bryan, M.S., Scott, R.A., Sorice, R., Tragante, V., Traglia, M., White, J., Yamamoto, K., Zhang, Y., Adair, L.S., Ahmed, A., Akiyama, K., Asif, R., Aung, T., Barroso, I., Bjonnes, A., Braun, T.R., Cai, H., Chang, L.-C., Chen, C.-H., Cheng, C.-Y., Chong, Y.-S., Collins, R., Courtney, R., Davies, G., Delgado, G., Do, L.D., Doevendans, P.A., Gansevoort, R.T., Gao, Y.-T., Grammer, T.B., Grarup, N., Grewal, J., Gu, D., Wander, G.S., Hartikainen, A.-L., Hazen, S.L., He, J., Heng, C.-K., Hixson, J.E., Hofman, A., Hsu, C., Huang, W., Husemoen, L.L.N., Hwang, J.-Y., Ichihara, S., Igase, M., Isono, M., Justesen, J.M., Katsuya, T., Kibriya, M.G., Kim, Y.J., Kishimoto, M., Koh, W.-P., Kohara, K., Kumari, M., Kwek, K., Lee, N.R., Lee, J., Liao, J., Lieb, W., Liewald, D.C.M., Matsubara, T., Matsushita, Y., Meitinger, T., Mihailov, E., Milani, L., Mills, R., Mononen, N., Müller-Nurasyid, M., Nabika, T., Nakashima, E., Ng, H.K., Nikus, K., Nutile, T., Ohkubo, T., Ohnaka, K., Parish, S., Paternoster, L., Peng, H., Peters, A., Pham, S.T., Pinidiyapathirage, M.J., Rahman, M., Rakugi, H., Rolandsson, O., Rozario, M.A., Ruggiero, D., Sala, C.F., Sarju, R., Shimokawa, K., Snieder, H., Sparsø, T., Spiering, W., Starr, J.M., Stott, D.J., Stram, D.O., Sugiyama, T., Szymczak, S., Tang, W.H.W., Tong, L., Trompet, S., Turjanmaa, V., Ueshima, H., Uitterlinden, A.G., Umemura, S., Vaarasmaki, M., van Dam, R.M., van Gilst, W.H., van Veldhuisen, D.J., Viikari, J.S., Waldenberger, M., Wang, Y., Wang, A., Wilson, R., Wong, T.-Y., Xiang, Y.-B., Yamaguchi, S., Ye, X., Young, R.D., Young, T.L., Yuan, J.-M., Zhou, X., Asselbergs, F.W., Ciullo, M., Clarke, R., Deloukas, P., Franke, A., Franks, P.W., Franks, S., Friedlander, Y., Gross, M.D., Guo, Z., Hansen, T., Jarvelin, M.-R., Jørgensen, T., Jukema, J.W., Kähönen, M., Kajio, H., Kivimaki, M., Lee, J.-Y., Lehtimäki, T., Linneberg, A., Miki, T., Pedersen, O., Samani, N.J., Sørensen, T.I.A., Takayanagi, R., Toniolo, D., BIOS-consortium, CARDIo GRAMplusCD, LifeLines Cohort Study, InterAct Consortium, Ahsan, H., Allayee, H., Chen, Y.-T., Danesh, J., Deary, I.J., Franco, O.H., Franke, L., Heijman, B.T., Holbrook, J.D., Isaacs, A., Kim, B.-J., Lin, X., Liu, J., März, W., Metspalu, A., Mohlke, K.L., Sanghera, D.K., Shu, X.-O., van Meurs, J.B.J., Vithana, E., Wickremasinghe, A.R., Wijmenga, C., Wolffenbuttel, B.H.W., Yokota, M., Zheng, W., Zhu, D., Vineis, P., Kyrtopoulos, S.A., Kleinjans, J.C.S., McCarthy, M.I., Soong, R., Gieger, C., Scott, J., Teo, Y.-Y., He, J., Elliott, P., Tai, E.S., van der Harst, P., Kooner, J.S., Chambers, J.C., 2015. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat. Genet. 47, 1282–1293. doi.org/10.1038/ng.3405

Kaufmann, S., Horger, T., Oelker, A., Beck, S., Schulze, M., Nikolaou, K., Ketelsen, D., Horger, M., 2015a. Volume perfusion computed tomography (VPCT)-based evaluation of response to TACE using two different sized drug eluting beads in patients with nonresectable hepatocellular carcinoma: Impact on tumor and liver parenchymal vascularisation. Eur J Radiol 84, 2548–2554. doi.org/10.1016/j.ejrad.2015.09.009

Kaufmann, S., Horger, T., Oelker, A., Kloth, C., Nikolaou, K., Schulze, M., Horger, M., 2015b. Characterization of hepatocellular carcinoma (HCC) lesions using a novel CT-based volume perfusion (VPCT) technique. Eur J Radiol 84, 1029–1035. doi.org/10.1016/j.ejrad.2015.02.020

Kempf, H., Bleicher, M., Meyer-Hermann, M., 2015. Spatio-Temporal Dynamics of Hypoxia during Radiotherapy. PLoS ONE 10, e0133357. doi.org/10.1371/journal.pone.0133357

Keßler, M., Rottbauer, W., Just, S., 2015. Recent progress in the use of zebrafish for novel cardiac drug discovery. Expert Opin Drug Discov 10, 1231–1241. doi.org/10.1517/17460441.2015.1078788

Kessler, T., Zhang, L., Liu, Z., Yin, X., Huang, Y., Wang, Y., Fu, Y., Mayr, M., Ge, Q., Xu, Q., Zhu, Y., Wang, X., Schmidt, K., de Wit, C., Erdmann, J., Schunkert, H., Aherrahrou, Z., Kong, W., 2015. ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1. Circulation 131, 1191–1201. doi.org/10.1161/CIRCULATIONAHA.114.014072

Koch, J., Freisinger, P., Feichtinger, R.G., Zimmermann, F.A., Rauscher, C., Wagentristl, H.P., Konstantopoulou, V., Seidl, R., Haack, T.B., Prokisch, H., Ahting, U., Sperl, W., Mayr, J.A., Maier, E.M., 2015. Mutations in TTC19: expanding the molecular, clinical and biochemical phenotype. Orphanet J Rare Dis 10, 40. doi.org/10.1186/s13023-015-0254-5

Koch, M., Baurecht, H., Ried, J.S., Rodriguez, E., Schlesinger, S., Volks, N., Gieger, C., Rückert, I.-M., Heinrich, L., Willenborg, C., Smith, C., Peters, A., Thorand, B., Koenig, W., Lamina, C., Jansen, H., Kronenberg, F., Seissler, J., Thiery, J., Rathmann, W., Schunkert, H., Erdmann, J., Barker, J., Nair, R.P., Tsoi, L.C., Elder, J.T., Mrowietz, U., Weichenthal, M., Mucha, S., Schreiber, S., Franke, A., Schmitt, J., Lieb, W., Weidinger, S., 2015. Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures. J. Invest. Dermatol. 135, 1283–1293. doi.org/10.1038/jid.2015.8

Kuiper, R., van Duin, M., van Vliet, M.H., Broijl, A., van der Holt, B., El Jarari, L., van Beers, E.H., Mulligan, G., Avet-Loiseau, H., Gregory, W.M., Morgan, G., Goldschmidt, H., Lokhorst, H.M., Sonneveld, P., 2015. Prediction of high- and low-risk multiple myeloma based on gene expression and the International Staging System. Blood 126, 1996–2004. doi.org/10.1182/blood-2015-05-644039

Kumar, D., Dedic, N., Flachskamm, C., Voulé, S., Deussing, J.M., Kimura, M., 2015. Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery. Sleep 38, 1371–1380. doi.org/10.5665/sleep.4972

Kunz, M., König, I.R., Schillert, A., Kruppa, J., Ziegler, A., Grallert, H., Müller-Nurasyid, M., Lieb, W., Franke, A., Ranki, A., Panelius, J., Koskenmies, S., Hasan, T., Kere, J., Rönn, A.-C., Simon, J.C., Schmidt, E., Wenzel, J., Tüting, T., Landsberg, J., Zeller, T., Blankenberg, S., Gläser, R., Patsinakidis, N., Kuhn, A., Ibrahim, S.M., 2015. Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus. Exp. Dermatol. 24, 510–515. doi.org/10.1111/exd.12708

Li, J., Jørgensen, S.F., Maggadottir, S.M., Bakay, M., Warnatz, K., Glessner, J., Pandey, R., Salzer, U., Schmidt, R.E., Perez, E., Resnick, E., Goldacker, S., Buchta, M., Witte, T., Padyukov, L., Videm, V., Folseraas, T., Atschekzei, F., Elder, J.T., Nair, R.P., Winkelmann, J., Gieger, C., Nöthen, M.M., Büning, C., Brand, S., Sullivan, K.E., Orange, J.S., Fevang, B., Schreiber, S., Lieb, W., Aukrust, P., Chapel, H., Cunningham-Rundles, C., Franke, A., Karlsen, T.H., Grimbacher, B., Hakonarson, H., Hammarström, L., Ellinghaus, E., 2015. Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nat Commun 6, 6804. doi.org/10.1038/ncomms7804

Lindner, C., Thomsen, I., Wahl, B., Ugur, M., Sethi, M.K., Friedrichsen, M., Smoczek, A., Ott, S., Baumann, U., Suerbaum, S., Schreiber, S., Bleich, A., Gaboriau-Routhiau, V., Cerf-Bensussan, N., Hazanov, H., Mehr, R., Boysen, P., Rosenstiel, P., Pabst, O., 2015. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat. Immunol. 16, 880–888. doi.org/10.1038/ni.3213

Lindner, S., Bachmann, H.S., Odersky, A., Schaefers, S., Klein-Hitpass, L., Hero, B., Fischer, M., Eggert, A., Schramm, A., Schulte, J.H., 2015. Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma. Biomed Rep 3, 443–446. doi.org/10.3892/br.2015.463

Luo, X.-J., Mattheisen, M., Li, M., Huang, L., Rietschel, M., Børglum, A.D., Als, T.D., van den Oord, E.J., Aberg, K.A., Mors, O., Mortensen, P.B., Luo, Z., Degenhardt, F., Cichon, S., Schulze, T.G., Nöthen, M.M., iPSYCH-GEMS SCZ working group, MooDS SCZ Consortium, Su, B., Zhao, Z., Gan, L., Yao, Y.-G., 2015. Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function. Schizophr Bull 41, 1294–1308. doi.org/10.1093/schbul/sbv017

Maes, K., De Smedt, E., Kassambara, A., Hose, D., Seckinger, A., Van Valckenborgh, E., Menu, E., Klein, B., Vanderkerken, K., Moreaux, J., De Bruyne, E., 2015. In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma. Oncotarget 6, 3319–3334. doi.org/10.18632/oncotarget.3207

Mai, E.K., Hielscher, T., Kloth, J.K., Merz, M., Shah, S., Raab, M.S., Hillengass, M., Wagner, B., Jauch, A., Hose, D., Weber, M.-A., Delorme, S., Goldschmidt, H., Hillengass, J., 2015. A magnetic resonance imaging-based prognostic scoring system to predict outcome in transplant-eligible patients with multiple myeloma. Haematologica 100, 818–825. doi.org/10.3324/haematol.2015.124115

Mallm, J.-P., Rippe, K., 2015. Aurora Kinase B Regulates Telomerase Activity via a Centromeric RNA in Stem Cells. Cell Rep 11, 1667–1678. doi.org/10.1016/j.celrep.2015.05.015

Masqué-Soler, N., Szczepanowski, M., Kohler, C.W., Aukema, S.M., Nagel, I., Richter, J., Siebert, R., Spang, R., Burkhardt, B., Klapper, W., 2015. Clinical and pathological features of Burkitt lymphoma showing expression of BCL2--an analysis including gene expression in formalin-fixed paraffin-embedded tissue. Br. J. Haematol. 171, 501–508. doi.org/10.1111/bjh.13624

Mayer-Wrangowski, S.C., Rauh, D., 2015. Monitoring ligand-induced conformational changes for the identification of estrogen receptor agonists and antagonists. Angew. Chem. Int. Ed. Engl. 54, 4379–4382. doi.org/10.1002/anie.201410148

Meier, A., Söding, J., 2015. Automatic Prediction of Protein 3D Structures by Probabilistic Multi-template Homology Modeling. PLoS Comput. Biol. 11, e1004343. doi.org/10.1371/journal.pcbi.1004343

Meißner, T., Seckinger, A., Hemminki, K., Bertsch, U., Foersti, A., Haenel, M., Duering, J., Salwender, H., Goldschmidt, H., Morgan, G.J., Hose, D., Weinhold, N., 2015. Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells. BMC Med Genomics 8, 85. doi.org/10.1186/s12920-015-0161-6

Melling, N., Thomsen, E., Tsourlakis, M.C., Kluth, M., Hube-Magg, C., Minner, S., Koop, C., Graefen, M., Heinzer, H., Wittmer, C., Sauter, G., Wilczak, W., Huland, H., Simon, R., Schlomm, T., Steurer, S., Krech, T., 2015. Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters. Carcinogenesis 36, 1333–1340. doi.org/10.1093/carcin/bgv137

Müller-Redetzky, H., Lienau, J., Suttorp, N., Witzenrath, M., 2015. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev 24, 516–524. doi.org/10.1183/16000617.0034-2015

Nguyen, V.K., Binder, S.C., Boianelli, A., Meyer-Hermann, M., Hernandez-Vargas, E.A., 2015. Ebola virus infection modeling and identifiability problems. Front Microbiol 6, 257. doi.org/10.3389/fmicb.2015.00257

Nikpay, M., Goel, A., Won, H.-H., Hall, L.M., Willenborg, C., Kanoni, S., Saleheen, D., Kyriakou, T., Nelson, C.P., Hopewell, J.C., Webb, T.R., Zeng, L., Dehghan, A., Alver, M., Armasu, S.M., Auro, K., Bjonnes, A., Chasman, D.I., Chen, S., Ford, I., Franceschini, N., Gieger, C., Grace, C., Gustafsson, S., Huang, J., Hwang, S.-J., Kim, Y.K., Kleber, M.E., Lau, K.W., Lu, X., Lu, Y., Lyytikäinen, L.-P., Mihailov, E., Morrison, A.C., Pervjakova, N., Qu, L., Rose, L.M., Salfati, E., Saxena, R., Scholz, M., Smith, A.V., Tikkanen, E., Uitterlinden, A., Yang, X., Zhang, W., Zhao, W., de Andrade, M., de Vries, P.S., van Zuydam, N.R., Anand, S.S., Bertram, L., Beutner, F., Dedoussis, G., Frossard, P., Gauguier, D., Goodall, A.H., Gottesman, O., Haber, M., Han, B.-G., Huang, J., Jalilzadeh, S., Kessler, T., König, I.R., Lannfelt, L., Lieb, W., Lind, L., Lindgren, C.M., Lokki, M.-L., Magnusson, P.K., Mallick, N.H., Mehra, N., Meitinger, T., Memon, F.-R., Morris, A.P., Nieminen, M.S., Pedersen, N.L., Peters, A., Rallidis, L.S., Rasheed, A., Samuel, M., Shah, S.H., Sinisalo, J., Stirrups, K.E., Trompet, S., Wang, L., Zaman, K.S., Ardissino, D., Boerwinkle, E., Borecki, I.B., Bottinger, E.P., Buring, J.E., Chambers, J.C., Collins, R., Cupples, L.A., Danesh, J., Demuth, I., Elosua, R., Epstein, S.E., Esko, T., Feitosa, M.F., Franco, O.H., Franzosi, M.G., Granger, C.B., Gu, D., Gudnason, V., Hall, A.S., Hamsten, A., Harris, T.B., Hazen, S.L., Hengstenberg, C., Hofman, A., Ingelsson, E., Iribarren, C., Jukema, J.W., Karhunen, P.J., Kim, B.-J., Kooner, J.S., Kullo, I.J., Lehtimäki, T., Loos, R.J.F., Melander, O., Metspalu, A., März, W., Palmer, C.N., Perola, M., Quertermous, T., Rader, D.J., Ridker, P.M., Ripatti, S., Roberts, R., Salomaa, V., Sanghera, D.K., Schwartz, S.M., Seedorf, U., Stewart, A.F., Stott, D.J., Thiery, J., Zalloua, P.A., O’Donnell, C.J., Reilly, M.P., Assimes, T.L., Thompson, J.R., Erdmann, J., Clarke, R., Watkins, H., Kathiresan, S., McPherson, R., Deloukas, P., Schunkert, H., Samani, N.J., Farrall, M., CARDIoGRAMplusC4D Consortium, 2015. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47, 1121–1130. doi.org/10.1038/ng.3396

Ojelade, S.A., Jia, T., Rodan, A.R., Chenyang, T., Kadrmas, J.L., Cattrell, A., Ruggeri, B., Charoen, P., Lemaitre, H., Banaschewski, T., Büchel, C., Bokde, A.L.W., Carvalho, F., Conrod, P.J., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P.A., Heinz, A., Ittermann, B., Lathrop, M., Lubbe, S., Martinot, J.-L., Paus, T., Smolka, M.N., Spanagel, R., O’Reilly, P.F., Laitinen, J., Veijola, J.M., Feng, J., Desrivières, S., Jarvelin, M.-R., IMAGEN Consortium, Schumann, G., Rothenfluh, A., 2015. Rsu1 regulates ethanol consumption in Drosophila and humans. Proc. Natl. Acad. Sci. U.S.A. 112, E4085-4093. doi.org/10.1073/pnas.1417222112

Oláhová, M., Hardy, S.A., Hall, J., Yarham, J.W., Haack, T.B., Wilson, W.C., Alston, C.L., He, L., Aznauryan, E., Brown, R.M., Brown, G.K., Morris, A.A.M., Mundy, H., Broomfield, A., Barbosa, I.A., Simpson, M.A., Deshpande, C., Moeslinger, D., Koch, J., Stettner, G.M., Bonnen, P.E., Prokisch, H., Lightowlers, R.N., McFarland, R., Chrzanowska-Lightowlers, Z.M.A., Taylor, R.W., 2015. LRPPRC mutations cause early-onset multisystem mitochondrial disease outside of the French-Canadian population. Brain 138, 3503–3519. doi.org/10.1093/brain/awv291

Ortuño-Sierra, J., Fonseca-Pedrero, E., Aritio-Solana, R., Velasco, A.M., de Luis, E.C., Schumann, G., Cattrell, A., Flor, H., Nees, F., Banaschewski, T., Bokde, A., Whelan, R., Buechel, C., Bromberg, U., Conrod, P., Frouin, V., Papadopoulos, D., Gallinat, J., Garavan, H., Heinz, A., Walter, H., Struve, M., Gowland, P., Paus, T., Poustka, L., Martinot, J.-L., Paillère-Martinot, M.-L., Vetter, N.C., Smolka, M.N., Lawrence, C., IMAGEN consortium, 2015. New evidence of factor structure and measurement invariance of the SDQ across five European nations. Eur Child Adolesc Psychiatry 24, 1523–1534. doi.org/10.1007/s00787-015-0729-x

Osterwald, S., Deeg, K.I., Chung, I., Parisotto, D., Wörz, S., Rohr, K., Erfle, H., Rippe, K., 2015. PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening. J. Cell. Sci. 128, 1887–1900. doi.org/10.1242/jcs.148296

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D.P., Curtin, J.A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A.C., Thyssen, J.P., den Dekker, H.T., Ferreira, M.A., Altmaier, E., Sleiman, P.M.A., Xiao, F.L., Gonzalez, J.R., Marenholz, I., Kalb, B., Pino-Yanes, M., Xu, C.-J., Carstensen, L., Groen-Blokhuis, M.M., Venturini, C., Pennell, C.E., Barton, S.J., Levin, A.M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G.A., Bacelis, J., Bunyavanich, S., Myers, R.A., Matanovic, A., Kumar, A., Tung, J.Y., Hirota, T., Kubo, M., McArdle, W.L., Henderson, A.J., Kemp, J.P., Zheng, J., Smith, G.D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M.A., Arnold, A., Homuth, G., Schmidt, C.O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L.L., Grarup, N., de Jongste, J.C., Rivadeneira, F., Hofman, A., Jaddoe, V.W.V., Pasmans, S.G.M.A., Elbert, N.J., Uitterlinden, A.G., Marks, G.B., Thompson, P.J., Matheson, M.C., Robertson, C.F., Australian Asthma Genetics Consortium (AAGC), Ried, J.S., Li, J., Zuo, X.B., Zheng, X.D., Yin, X.Y., Sun, L.D., McAleer, M.A., O’Regan, G.M., Fahy, C.M.R., Campbell, L.E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D.S., Feenstra, B., Geller, F., Hottenga, J.J., Middeldorp, C.M., Hysi, P., Bataille, V., Spector, T., Tiesler, C.M.T., Thiering, E., Pahukasahasram, B., Yang, J.J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C.L., Myhre, R., Nystad, W., Custovic, A., Weiss, S.T., Meyers, D.A., Söderhäll, C., Melén, E., Ober, C., Raby, B.A., Simpson, A., Jacobsson, B., Holloway, J.W., Bisgaard, H., Sunyer, J., Probst-Hensch, N.M., Williams, L.K., Godfrey, K.M., Wang, C.A., Boomsma, D.I., Melbye, M., Koppelman, G.H., Jarvis, D., McLean, W.H.I., Irvine, A.D., Zhang, X.J., Hakonarson, H., Gieger, C., Burchard, E.G., Martin, N.G., Duijts, L., Linneberg, A., Jarvelin, M.-R., Nöthen, M.M., Lau, S., Hübner, N., Lee, Y.-A., Tamari, M., Hinds, D.A., Glass, D., Brown, S.J., Heinrich, J., Evans, D.M., Weidinger, S., EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, 2015. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat. Genet. 47, 1449–1456. doi.org/10.1038/ng.3424

Peifer, M., Hertwig, F., Roels, F., Dreidax, D., Gartlgruber, M., Menon, R., Krämer, A., Roncaioli, J.L., Sand, F., Heuckmann, J.M., Ikram, F., Schmidt, R., Ackermann, S., Engesser, A., Kahlert, Y., Vogel, W., Altmüller, J., Nürnberg, P., Thierry-Mieg, J., Thierry-Mieg, D., Mariappan, A., Heynck, S., Mariotti, E., Henrich, K.-O., Gloeckner, C., Bosco, G., Leuschner, I., Schweiger, M.R., Savelyeva, L., Watkins, S.C., Shao, C., Bell, E., Höfer, T., Achter, V., Lang, U., Theissen, J., Volland, R., Saadati, M., Eggert, A., de Wilde, B., Berthold, F., Peng, Z., Zhao, C., Shi, L., Ortmann, M., Büttner, R., Perner, S., Hero, B., Schramm, A., Schulte, J.H., Herrmann, C., O’Sullivan, R.J., Westermann, F., Thomas, R.K., Fischer, M., 2015. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature 526, 700–704. doi.org/10.1038/nature14980

Peters, M.J., Joehanes, R., Pilling, L.C., Schurmann, C., Conneely, K.N., Powell, J., Reinmaa, E., Sutphin, G.L., Zhernakova, A., Schramm, K., Wilson, Y.A., Kobes, S., Tukiainen, T., NABEC/UKBEC Consortium, Ramos, Y.F., Göring, H.H.H., Fornage, M., Liu, Y., Gharib, S.A., Stranger, B.E., De Jager, P.L., Aviv, A., Levy, D., Murabito, J.M., Munson, P.J., Huan, T., Hofman, A., Uitterlinden, A.G., Rivadeneira, F., van Rooij, J., Stolk, L., Broer, L., Verbiest, M.M.P.J., Jhamai, M., Arp, P., Metspalu, A., Tserel, L., Milani, L., Samani, N.J., Peterson, P., Kasela, S., Codd, V., Peters, A., Ward-Caviness, C.K., Herder, C., Waldenberger, M., Roden, M., Singmann, P., Zeilinger, S., Illig, T., Homuth, G., Grabe, H.-J., Völzke, H., Steil, L., Kocher, T., Murray, A., Melzer, D., Yaghootkar, H., Bandinelli, S., Moses, E.K., Kent, J.W., Curran, J.E., Johnson, M.P., Williams-Blangero, S., Westra, H.-J., McRae, A.F., Smith, J.A., Kardia, S.L.R., Hovatta, I., Perola, M., Ripatti, S., Salomaa, V., Henders, A.K., Martin, N.G., Smith, A.K., Mehta, D., Binder, E.B., Nylocks, K.M., Kennedy, E.M., Klengel, T., Ding, J., Suchy-Dicey, A.M., Enquobahrie, D.A., Brody, J., Rotter, J.I., Chen, Y.-D.I., Houwing-Duistermaat, J., Kloppenburg, M., Slagboom, P.E., Helmer, Q., den Hollander, W., Bean, S., Raj, T., Bakhshi, N., Wang, Q.P., Oyston, L.J., Psaty, B.M., Tracy, R.P., Montgomery, G.W., Turner, S.T., Blangero, J., Meulenbelt, I., Ressler, K.J., Yang, J., Franke, L., Kettunen, J., Visscher, P.M., Neely, G.G., Korstanje, R., Hanson, R.L., Prokisch, H., Ferrucci, L., Esko, T., Teumer, A., van Meurs, J.B.J., Johnson, A.D., 2015. The transcriptional landscape of age in human peripheral blood. Nat Commun 6, 8570. doi.org/10.1038/ncomms9570

Peykov, S., Berkel, S., Schoen, M., Weiss, K., Degenhardt, F., Strohmaier, J., Weiss, B., Proepper, C., Schratt, G., Nöthen, M.M., Boeckers, T.M., Rietschel, M., Rappold, G.A., 2015. Identification and functional characterization of rare SHANK2 variants in schizophrenia. Mol. Psychiatry 20, 1489–1498. doi.org/10.1038/mp.2014.172

Pfarr, S., Meinhardt, M.W., Klee, M.L., Hansson, A.C., Vengeliene, V., Schönig, K., Bartsch, D., Hope, B.T., Spanagel, R., Sommer, W.H., 2015. Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex. J. Neurosci. 35, 10750–10761. doi.org/10.1523/JNEUROSCI.0684-15.2015

Powell, C.A., Kopajtich, R., D’Souza, A.R., Rorbach, J., Kremer, L.S., Husain, R.A., Dallabona, C., Donnini, C., Alston, C.L., Griffin, H., Pyle, A., Chinnery, P.F., Strom, T.M., Meitinger, T., Rodenburg, R.J., Schottmann, G., Schuelke, M., Romain, N., Haller, R.G., Ferrero, I., Haack, T.B., Taylor, R.W., Prokisch, H., Minczuk, M., 2015. TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies. Am. J. Hum. Genet. 97, 319–328. doi.org/10.1016/j.ajhg.2015.06.011

Reppe, K., Radünzel, P., Dietert, K., Tschernig, T., Wolff, T., Hammerschmidt, S., Gruber, A.D., Suttorp, N., Witzenrath, M., 2015. Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. Infect. Immun. 83, 4617–4629. doi.org/10.1128/IAI.00948-15

Richiardi, J., Altmann, A., Milazzo, A.-C., Chang, C., Chakravarty, M.M., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Bromberg, U., Büchel, C., Conrod, P., Fauth-Bühler, M., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Lemaître, H., Mann, K.F., Martinot, J.-L., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Robbins, T.W., Smolka, M.N., Spanagel, R., Ströhle, A., Schumann, G., Hawrylycz, M., Poline, J.-B., Greicius, M.D., IMAGEN consortium, 2015. BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. Science 348, 1241–1244. doi.org/10.1126/science.1255905

Richters, A., Basu, D., Engel, J., Ercanoglu, M.S., Balke-Want, H., Tesch, R., Thomas, R.K., Rauh, D., 2015. Identification and further development of potent TBK1 inhibitors. ACS Chem. Biol. 10, 289–298. doi.org/10.1021/cb500908d

Rippe, K., Luke, B., 2015. TERRA and the state of the telomere. Nat. Struct. Mol. Biol. 22, 853–858. doi.org/10.1038/nsmb.3078

Ruggeri, B., Nymberg, C., Vuoksimaa, E., Lourdusamy, A., Wong, C.P., Carvalho, F.M., Jia, T., Cattrell, A., Macare, C., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Bromberg, U., Büchel, C., Conrod, P.J., Fauth-Bühler, M., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Nees, F., Pausova, Z., Paus, T., Rietschel, M., Robbins, T., Smolka, M.N., Spanagel, R., Bakalkin, G., Mill, J., Sommer, W.H., Rose, R.J., Yan, J., Aliev, F., Dick, D., Kaprio, J., Desrivières, S., Schumann, G., IMAGEN Consortium, 2015. Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. Am J Psychiatry 172, 543–552. doi.org/10.1176/appi.ajp.2014.14030382

Sass, S., Pitea, A., Unger, K., Hess, J., Mueller, N.S., Theis, F.J., 2015. MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci 16, 30204–30222. doi.org/10.3390/ijms161226230

Schaarschmidt, H., Ellinghaus, D., Rodríguez, E., Kretschmer, A., Baurecht, H., Lipinski, S., Meyer-Hoffert, U., Harder, J., Lieb, W., Novak, N., Fölster-Holst, R., Esparza-Gordillo, J., Marenholz, I., Ruschendorf, F., Hubner, N., Reischl, E., Waldenberger, M., Gieger, C., Illig, T., Kabesch, M., Zhang, X.-J., Xiao, F.-L., Lee, Y.-A., Franke, A., Weidinger, S., 2015. A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis. J. Allergy Clin. Immunol. 136, 802–806. doi.org/10.1016/j.jaci.2015.01.047

Scheffler, M., Merkelbach-Bruse, S., Bos, M., Fassunke, J., Gardizi, M., Michels, S., Groneck, L., Schultheis, A.M., Malchers, F., Leenders, F., Kobe, C., König, K., Heukamp, L.C., Sos, M.L., Thomas, R.K., Büttner, R., Wolf, J., 2015. Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient. J Thorac Oncol 10, e40-43. doi.org/10.1097/JTO.0000000000000503

Schmack, K., Rössler, H., Sekutowicz, M., Brandl, E.J., Müller, D.J., Petrovic, P., Sterzer, P., 2015. Linking unfounded beliefs to genetic dopamine availability. Front Hum Neurosci 9, 521. doi.org/10.3389/fnhum.2015.00521

Schneeweiß, S., Horger, M., Ketelsen, D., Ioanoviciu, S.D., 2015. [Complications after TACE in HCC]. Rofo 36, 79–82. doi.org/10.1055/s-0034-1369532

Schramm, A., Köster, J., Assenov, Y., Althoff, K., Peifer, M., Mahlow, E., Odersky, A., Beisser, D., Ernst, C., Henssen, A.G., Stephan, H., Schröder, C., Heukamp, L., Engesser, A., Kahlert, Y., Theissen, J., Hero, B., Roels, F., Altmüller, J., Nürnberg, P., Astrahantseff, K., Gloeckner, C., De Preter, K., Plass, C., Lee, S., Lode, H.N., Henrich, K.-O., Gartlgruber, M., Speleman, F., Schmezer, P., Westermann, F., Rahmann, S., Fischer, M., Eggert, A., Schulte, J.H., 2015. Mutational dynamics between primary and relapse neuroblastomas. Nat. Genet. 47, 872–877. doi.org/10.1038/ng.3349

Schultheis, A.M., Scheel, A.H., Ozretić, L., George, J., Thomas, R.K., Hagemann, T., Zander, T., Wolf, J., Buettner, R., 2015. PD-L1 expression in small cell neuroendocrine carcinomas. Eur. J. Cancer 51, 421–426. doi.org/10.1016/j.ejca.2014.12.006

Seidel, M.G., Hirschmugl, T., Gamez-Diaz, L., Schwinger, W., Serwas, N., Deutschmann, A., Gorkiewicz, G., Zenz, W., Windpassinger, C., Grimbacher, B., Urban, C., Boztug, K., 2015. Long-term remission after allogeneic hematopoietic stem cell transplantation in LPS-responsive beige-like anchor (LRBA) deficiency. J. Allergy Clin. Immunol. 135, 1384-1390–8. doi.org/10.1016/j.jaci.2014.10.048

Seo, S., Mohr, J., Beck, A., Wüstenberg, T., Heinz, A., Obermayer, K., 2015. Predicting the future relapse of alcohol-dependent patients from structural and functional brain images. Addict Biol 20, 1042–1055. doi.org/10.1111/adb.12302

Seo, S., Mohr, J., Li, N., Horn, A., Obermayer, K., 2015. Incremental pairwise clustering for large proximity matrices, in: 2015 International Joint Conference on Neural Networks (IJCNN). Presented at the 2015 International Joint Conference on Neural Networks (IJCNN), pp. 1–8. doi.org/10.1109/IJCNN.2015.7280637

Spechler, P.A., Orr, C.A., Chaarani, B., Kan, K.-J., Mackey, S., Morton, A., Snowe, M.P., Hudson, K.E., Althoff, R.R., Higgins, S.T., Cattrell, A., Flor, H., Nees, F., Banaschewski, T., Bokde, A.L.W., Whelan, R., Büchel, C., Bromberg, U., Conrod, P., Frouin, V., Papadopoulos, D., Gallinat, J., Heinz, A., Walter, H., Ittermann, B., Gowland, P., Paus, T., Poustka, L., Martinot, J.-L., Artiges, E., Smolka, M.N., Schumann, G., Garavan, H., IMAGEN Consortium, 2015. Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat. Dev Cogn Neurosci 16, 63–70. doi.org/10.1016/j.dcn.2015.08.007

Spyroglou, A., Riester, A., Mueller-Peltzer, K., Lu, A., Rohde, J., Hantel, C., Kuehne, C., Kulle, A., Riepe, F., Deussing, J.M., Beuschlein, F., 2015. Adrenal and Ovarian Phenotype of a Tissue-Specific Urocortin 2-Overexpressing Mouse Model. Endocrinology 156, 2646–2656. doi.org/10.1210/en.2014-1971

Stappert, L., Roese-Koerner, B., Brüstle, O., 2015. The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification. Cell Tissue Res. 359, 47–64. doi.org/10.1007/s00441-014-1981-y

Stepniak, B., Kästner, A., Poggi, G., Mitjans, M., Begemann, M., Hartmann, A., Van der Auwera, S., Sananbenesi, F., Krueger-Burg, D., Matuszko, G., Brosi, C., Homuth, G., Völzke, H., Benseler, F., Bagni, C., Fischer, U., Dityatev, A., Grabe, H.-J., Rujescu, D., Fischer, A., Ehrenreich, H., 2015. Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes. EMBO Mol Med 7, 1565–1579. doi.org/10.15252/emmm.201505696

Stringaris, A., Vidal-Ribas Belil, P., Artiges, E., Lemaitre, H., Gollier-Briant, F., Wolke, S., Vulser, H., Miranda, R., Penttilä, J., Struve, M., Fadai, T., Kappel, V., Grimmer, Y., Goodman, R., Poustka, L., Conrod, P., Cattrell, A., Banaschewski, T., Bokde, A.L.W., Bromberg, U., Büchel, C., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Nees, F., Papadopoulos, D., Paus, T., Smolka, M.N., Walter, H., Whelan, R., Martinot, J.-L., Schumann, G., Paillère-Martinot, M.-L., IMAGEN Consortium, 2015. The Brain’s Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample. Am J Psychiatry 172, 1215–1223. doi.org/10.1176/appi.ajp.2015.14101298

Stuart, P.E., Nair, R.P., Tsoi, L.C., Tejasvi, T., Das, S., Kang, H.M., Ellinghaus, E., Chandran, V., Callis-Duffin, K., Ike, R., Li, Y., Wen, X., Enerbäck, C., Gudjonsson, J.E., Kõks, S., Kingo, K., Esko, T., Mrowietz, U., Reis, A., Wichmann, H.E., Gieger, C., Hoffmann, P., Nöthen, M.M., Winkelmann, J., Kunz, M., Moreta, E.G., Mease, P.J., Ritchlin, C.T., Bowcock, A.M., Krueger, G.G., Lim, H.W., Weidinger, S., Weichenthal, M., Voorhees, J.J., Rahman, P., Gregersen, P.K., Franke, A., Gladman, D.D., Abecasis, G.R., Elder, J.T., 2015. Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. Am. J. Hum. Genet. 97, 816–836. doi.org/10.1016/j.ajhg.2015.10.019

Sukhorukov, V.M., Meyer-Hermann, M., 2015. Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton. Sci Rep 5, 13924. doi.org/10.1038/srep13924

Tomaschitz, A., Pilz, S., Rus-Machan, J., Meinitzer, A., Brandenburg, V.M., Scharnagl, H., Kapl, M., Grammer, T., Ritz, E., Horina, J.H., Kleber, M.E., Pieske, B., Kraigher-Krainer, E., Hartaigh, B.Ó., Toplak, H., van Ballegooijen, A.J., Amrein, K., Fahrleitner-Pammer, A., März, W., 2015. Interrelated aldosterone and parathyroid hormone mutually modify cardiovascular mortality risk. Int. J. Cardiol. 184, 710–716. doi.org/10.1016/j.ijcard.2015.03.062

Tsoi, L.C., Spain, S.L., Ellinghaus, E., Stuart, P.E., Capon, F., Knight, J., Tejasvi, T., Kang, H.M., Allen, M.H., Lambert, S., Stoll, S.W., Weidinger, S., Gudjonsson, J.E., Koks, S., Kingo, K., Esko, T., Das, S., Metspalu, A., Weichenthal, M., Enerback, C., Krueger, G.G., Voorhees, J.J., Chandran, V., Rosen, C.F., Rahman, P., Gladman, D.D., Reis, A., Nair, R.P., Franke, A., Barker, J.N.W.N., Abecasis, G.R., Trembath, R.C., Elder, J.T., 2015. Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nat Commun 6, 7001. doi.org/10.1038/ncomms8001

Van der Auwera, S., Wittfeld, K., Homuth, G., Teumer, A., Hegenscheid, K., Grabe, H.J., 2015. No association between polygenic risk for schizophrenia and brain volume in the general population. Biol. Psychiatry 78, e41-42. doi.org/10.1016/j.biopsych.2015.02.038

Vengeliene, V., Noori, H.R., Spanagel, R., 2015a. Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption. Neuropsychopharmacology 40, 2897–2906. doi.org/10.1038/npp.2015.143

Vengeliene, V., Olevska, A., Spanagel, R., 2015b. Long-lasting effect of NMDA receptor antagonist memantine on ethanol-cue association and relapse. J. Neurochem. 135, 1080–1085. doi.org/10.1111/jnc.13350

Vierheller, J., Neubert, W., Falcke, M., Gilbert, S.H., Chamakuri, N., 2015. A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles. Front Physiol 6, 255. doi.org/10.3389/fphys.2015.00255

von der Heyde, S., Wagner, S., Czerny, A., Nietert, M., Ludewig, F., Salinas-Riester, G., Arlt, D., Beißbarth, T., 2015. mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer. PLoS ONE 10, e0117818. doi.org/10.1371/journal.pone.0117818

Vulser, H., Lemaitre, H., Artiges, E., Miranda, R., Penttilä, J., Struve, M., Fadai, T., Kappel, V., Grimmer, Y., Goodman, R., Stringaris, A., Poustka, L., Conrod, P., Frouin, V., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Bromberg, U., Büchel, C., Flor, H., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lawrence, C., Loth, E., Mann, K., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Robbins, T.W., Smolka, M.N., Schumann, G., Martinot, J.-L., Paillère-Martinot, M.-L., IMAGEN Consortium (www.imagen-europe.com), IMAGEN Consortium www imagen-europe com, 2015. Subthreshold depression and regional brain volumes in young community adolescents. J Am Acad Child Adolesc Psychiatry 54, 832–840. doi.org/10.1016/j.jaac.2015.07.006

Wachter, A., Beißbarth, T., 2015. pwOmics: an R package for pathway-based integration of time-series omics data using public database knowledge. Bioinformatics 31, 3072–3074. doi.org/10.1093/bioinformatics/btv323

Wachter, A., Bernhardt, S., Beissbarth, T., Korf, U., 2015. Analysis of Reverse Phase Protein Array Data: From Experimental Design towards Targeted Biomarker Discovery. Microarrays 4, 520–539. doi.org/10.3390/microarrays4040520

Wehr, C., Gennery, A.R., Lindemans, C., Schulz, A., Hoenig, M., Marks, R., Recher, M., Gruhn, B., Holbro, A., Heijnen, I., Meyer, D., Grigoleit, G., Einsele, H., Baumann, U., Witte, T., Sykora, K.-W., Goldacker, S., Regairaz, L., Aksoylar, S., Ardeniz, Ö., Zecca, M., Zdziarski, P., Meyts, I., Matthes-Martin, S., Imai, K., Kamae, C., Fielding, A., Seneviratne, S., Mahlaoui, N., Slatter, M.A., Güngör, T., Arkwright, P.D., van Montfrans, J., Sullivan, K.E., Grimbacher, B., Cant, A., Peter, H.-H., Finke, J., Gaspar, H.B., Warnatz, K., Rizzi, M., Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiency, 2015. Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency. J. Allergy Clin. Immunol. 135, 988–997.e6. doi.org/10.1016/j.jaci.2014.11.029

Weinhold, N., Meissner, T., Johnson, D.C., Seckinger, A., Moreaux, J., Försti, A., Chen, B., Nickel, J., Chubb, D., Rawstron, A.C., Doughty, C., Dahir, N.B., Begum, D.B., Young, K., Walker, B.A., Hoffmann, P., Nöthen, M.M., Davies, F.E., Klein, B., Goldschmidt, H., Morgan, G.J., Houlston, R.S., Hose, D., Hemminki, K., 2015. The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells. Haematologica 100, e110-113. doi.org/10.3324/haematol.2014.118786

Weisner, J., Gontla, R., van der Westhuizen, L., Oeck, S., Ketzer, J., Janning, P., Richters, A., Mühlenberg, T., Fang, Z., Taher, A., Jendrossek, V., Pelly, S.C., Bauer, S., van Otterlo, W.A.L., Rauh, D., 2015. Covalent-Allosteric Kinase Inhibitors. Angew. Chem. Int. Ed. Engl. 54, 10313–10316. doi.org/10.1002/anie.201502142

Weist, B.J.D., Wehler, P., El Ahmad, L., Schmueck-Henneresse, M., Millward, J.M., Nienen, M., Neumann, A.U., Reinke, P., Babel, N., 2015. A revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients. Kidney Int. 88, 1293–1303. doi.org/10.1038/ki.2015.215

Willert, A., Mohnke, S., Erk, S., Schnell, K., Romanczuk-Seiferth, N., Quinlivan, E., Schreiter, S., Spengler, S., Herold, D., Wackerhagen, C., Romund, L., Garbusow, M., Lett, T., Stamm, T., Adli, M., Heinz, A., Bermpohl, F., Walter, H., 2015. Alterations in neural Theory of Mind processing in euthymic patients with bipolar disorder and unaffected relatives. Bipolar Disord 17, 880–891. doi.org/10.1111/bdi.12352

Yin, X., Low, H.Q., Wang, L., Li, Y., Ellinghaus, E., Han, J., Estivill, X., Sun, L., Zuo, X., Shen, C., Zhu, C., Zhang, A., Sanchez, F., Padyukov, L., Catanese, J.J., Krueger, G.G., Duffin, K.C., Mucha, S., Weichenthal, M., Weidinger, S., Lieb, W., Foo, J.N., Li, Y., Sim, K., Liany, H., Irwan, I., Teo, Y., Theng, C.T.S., Gupta, R., Bowcock, A., De Jager, P.L., Qureshi, A.A., de Bakker, P.I.W., Seielstad, M., Liao, W., Ståhle, M., Franke, A., Zhang, X., Liu, J., 2015. Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun 6, 6916. doi.org/10.1038/ncomms7916

Yousri, N.A., Mook-Kanamori, D.O., Selim, M.M.E.-D., Takiddin, A.H., Al-Homsi, H., Al-Mahmoud, K.A.S., Karoly, E.D., Krumsiek, J., Do, K.T., Do, K.T., Neumaier, U., Mook-Kanamori, M.J., Rowe, J., Chidiac, O.M., McKeon, C., Al Muftah, W.A., Kader, S.A., Kastenmüller, G., Suhre, K., 2015. A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control. Diabetologia 58, 1855–1867. doi.org/10.1007/s00125-015-3636-2

2014

Aichler, M., Luber, B., Lordick, F., Walch, A., 2014a. Proteomic and metabolic prediction of response to therapy in gastric cancer. World J. Gastroenterol. 20, 13648–13657. http://doi.org/10.3748/wjg.v20.i38.13648

Aichler, M., Motschmann, M., Jütting, U., Luber, B., Becker, K., Ott, K., Lordick, F., Langer, R., Feith, M., Siewert, J.R., Walch, A., 2014b. Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy. Oncotarget 5, 6620–6632. http://doi.org/10.18632/oncotarget.2268

Ganzinger, M., Gietzelt, M., Karmen, C., Firnkorn, D., Knaup, P., 2015. An IT Architecture for Systems Medicine. Stud Health Technol Inform 210, 185–189. http://doi.org/10.3233/978-1-61499-512-8-185

Giusti, S.A., Vercelli, C.A., Vogl, A.M., Kolarz, A.W., Pino, N.S., Deussing, J.M., Refojo, D., 2014. Behavioral phenotyping of Nestin-Cre mice: implications for genetic mouse models of psychiatric disorders. J Psychiatr Res 55, 87–95. http://doi.org/10.1016/j.jpsychires.2014.04.002

Grammer, T.B., Kleber, M.E., Silbernagel, G., Pilz, S., Scharnagl, H., Tomaschitz, A., König, W., März, W., 2014. Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study). Atherosclerosis 236, 292–300. http://doi.org/10.1016/j.atherosclerosis.2014.07.002

Haering, M., Hördt, A., Meyer-Hermann, M., Hernandez-Vargas, E.A., 2014. Computational study to determine when to initiate and alternate therapy in HIV infection. Biomed Res Int 2014, 472869. http://doi.org/10.1155/2014/472869

Hertäg, L., Durstewitz, D., Brunel, N., 2014. Analytical approximations of the firing rate of an adaptive exponential integrate-and-fire neuron in the presence of synaptic noise. Front Comput Neurosci 8, 116. http://doi.org/10.3389/fncom.2014.00116

Karmen, C., Ganzinger, M., Kohl, C.D., Firnkorn, D., Knaup-Gregori, P., 2014. A framework for integrating heterogeneous clinical data for a disease area into a central data warehouse. Stud Health Technol Inform 205, 1060–1064. http://doi.org/10.3233/978-1-61499-432-9-1060

Karus, M., Blaess, S., Brüstle, O., 2014. Self-organization of neural tissue architectures from pluripotent stem cells. J. Comp. Neurol. 522, 2831–2844. http://doi.org/10.1002/cne.23608

Loth, E., Poline, J.-B., Thyreau, B., Jia, T., Tao, C., Lourdusamy, A., Stacey, D., Cattrell, A., Desrivières, S., Ruggeri, B., Fritsch, V., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Büchel, C., Carvalho, F.M., Conrod, P.J., Fauth-Buehler, M., Flor, H., Gallinat, J., Garavan, H., Heinz, A., Bruehl, R., Lawrence, C., Mann, K., Martinot, J.-L., Nees, F., Paus, T., Pausova, Z., Poustka, L., Rietschel, M., Smolka, M., Struve, M., Feng, J., Schumann, G., IMAGEN Consortium, 2014. Oxytocin receptor genotype modulates ventral striatal activity to social cues and response to stressful life events. Biol. Psychiatry 76, 367–376. http://doi.org/10.1016/j.biopsych.2013.07.043

Meyer-Hermann, M., 2014. Overcoming the dichotomy of quantity and quality in antibody responses. J. Immunol. 193, 5414–5419. http://doi.org/10.4049/jimmunol.1401828

Miller, C.L., Haas, U., Diaz, R., Leeper, N.J., Kundu, R.K., Patlolla, B., Assimes, T.L., Kaiser, F.J., Perisic, L., Hedin, U., Maegdefessel, L., Schunkert, H., Erdmann, J., Quertermous, T., Sczakiel, G., 2014. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genet. 10, e1004263. http://doi.org/10.1371/journal.pgen.1004263

Mohr, J., Seo, S., Obermayer, K., 2014. A classifier-based association test for imbalanced data derived from prediction theory, in: 2014 International Joint Conference on Neural Networks (IJCNN). Presented at the 2014 International Joint Conference on Neural Networks (IJCNN), pp. 487–493. http://doi.org/10.1109/IJCNN.2014.6889547

Morgan, G.J., Johnson, D.C., Weinhold, N., Goldschmidt, H., Landgren, O., Lynch, H.T., Hemminki, K., Houlston, R.S., 2014. Inherited genetic susceptibility to multiple myeloma. Leukemia 28, 518–524. http://doi.org/10.1038/leu.2013.344

Mühleisen, T.W., Leber, M., Schulze, T.G., Strohmaier, J., Degenhardt, F., Treutlein, J., Mattheisen, M., Forstner, A.J., Schumacher, J., Breuer, R., Meier, S., Herms, S., Hoffmann, P., Lacour, A., Witt, S.H., Reif, A., Müller-Myhsok, B., Lucae, S., Maier, W., Schwarz, M., Vedder, H., Kammerer-Ciernioch, J., Pfennig, A., Bauer, M., Hautzinger, M., Moebus, S., Priebe, L., Czerski, P.M., Hauser, J., Lissowska, J., Szeszenia-Dabrowska, N., Brennan, P., McKay, J.D., Wright, A., Mitchell, P.B., Fullerton, J.M., Schofield, P.R., Montgomery, G.W., Medland, S.E., Gordon, S.D., Martin, N.G., Krasnow, V., Chuchalin, A., Babadjanova, G., Pantelejeva, G., Abramova, L.I., Tiganov, A.S., Polonikov, A., Khusnutdinova, E., Alda, M., Grof, P., Rouleau, G.A., Turecki, G., Laprise, C., Rivas, F., Mayoral, F., Kogevinas, M., Grigoroiu-Serbanescu, M., Propping, P., Becker, T., Rietschel, M., Nöthen, M.M., Cichon, S., 2014. Genome-wide association study reveals two new risk loci for bipolar disorder. Nat Commun 5, 3339. http://doi.org/10.1038/ncomms4339

Murr, C., Grammer, T.B., Meinitzer, A., Kleber, M.E., März, W., Fuchs, D., 2014. Immune activation and inflammation in patients with cardiovascular disease are associated with higher phenylalanine to tyrosine ratios: the ludwigshafen risk and cardiovascular health study. J Amino Acids 2014, 783730. http://doi.org/10.1155/2014/783730

Myocardial Infarction Genetics Consortium Investigators, 2014. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N. Engl. J. Med. 371, 2072–2082. http://doi.org/10.1056/NEJMoa1405386

Noori, H.R., Helinski, S., Spanagel, R., 2014a. Cluster and meta-analyses on factors influencing stress-induced alcohol drinking and relapse in rodents. Addict Biol 19, 225–232. http://doi.org/10.1111/adb.12125

Noori, H.R., Mucksch, C., Urbassek, H.M., 2014b. A structural feature of the non-peptide ligand interactions with mice mu-opioid receptors. Curr Comput Aided Drug Des 10, 354–360. http://doi.org/10.2174/1573409910666141031093504

Richters, A., Nguyen, H.D., Phan, T., Simard, J.R., Grütter, C., Engel, J., Rauh, D., 2014. Identification of type II and III DDR2 inhibitors. J. Med. Chem. 57, 4252–4262. http://doi.org/10.1021/jm500167q

Schacht, T., Oswald, M., Eils, R., Eichmüller, S.B., König, R., 2014. Estimating the activity of transcription factors by the effect on their target genes. Bioinformatics 30, i401-407. http://doi.org/10.1093/bioinformatics/btu446

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427. http://doi.org/10.1038/nature13595

Schubert, D., Bode, C., Kenefeck, R., Hou, T.Z., Wing, J.B., Kennedy, A., Bulashevska, A., Petersen, B.-S., Schäffer, A.A., Grüning, B.A., Unger, S., Frede, N., Baumann, U., Witte, T., Schmidt, R.E., Dueckers, G., Niehues, T., Seneviratne, S., Kanariou, M., Speckmann, C., Ehl, S., Rensing-Ehl, A., Warnatz, K., Rakhmanov, M., Thimme, R., Hasselblatt, P., Emmerich, F., Cathomen, T., Backofen, R., Fisch, P., Seidl, M., May, A., Schmitt-Graeff, A., Ikemizu, S., Salzer, U., Franke, A., Sakaguchi, S., Walker, L.S.K., Sansom, D.M., Grimbacher, B., 2014. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat. Med. 20, 1410–1416. http://doi.org/10.1038/nm.3746

Siebert, M., Söding, J., 2014. Universality of core promoter elements? Nature 511, E11-12. http://doi.org/10.1038/nature13587

Sommer, W.H., Costa, R.M., Hansson, A.C., 2014. Dopamine systems adaptation during acquisition and consolidation of a skill. Front Integr Neurosci 8, 87. http://doi.org/10.3389/fnint.2014.00087

Spanagel, R., Noori, H.R., Heilig, M., 2014. Stress and alcohol interactions: animal studies and clinical significance. Trends Neurosci. 37, 219–227. http://doi.org/10.1016/j.tins.2014.02.006

Traylor, M., Mäkelä, K.-M., Kilarski, L.L., Holliday, E.G., Devan, W.J., Nalls, M.A., Wiggins, K.L., Zhao, W., Cheng, Y.-C., Achterberg, S., Malik, R., Sudlow, C., Bevan, S., Raitoharju, E., METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2), Oksala, N., Thijs, V., Lemmens, R., Lindgren, A., Slowik, A., Maguire, J.M., Walters, M., Algra, A., Sharma, P., Attia, J.R., Boncoraglio, G.B., Rothwell, P.M., de Bakker, P.I.W., Bis, J.C., Saleheen, D., Kittner, S.J., Mitchell, B.D., Rosand, J., Meschia, J.F., Levi, C., Dichgans, M., Lehtimäki, T., Lewis, C.M., Markus, H.S., 2014. A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. PLoS Genet. 10, e1004469. http://doi.org/10.1371/journal.pgen.1004469

Treutlein, J., Strohmaier, J., Frank, J., Mühleisen, T.W., Degenhardt, F., Witt, S.H., Schulze, T.G., Cichon, S., Nöthen, M.M., Rietschel, M., 2014. Smoking behaviour: investigation of the coaction of environmental and genetic risk factors. Psychiatr. Genet. 24, 279–280. http://doi.org/10.1097/YPG.0000000000000051

Vengeliene, V., Bilbao, A., Spanagel, R., 2014. The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice. Alcohol 48, 313–320. http://doi.org/10.1016/j.alcohol.2014.03.002

Weinhold, N., Försti, A., da Silva Filho, M.I., Nickel, J., Campo, C., Hoffmann, P., Nöthen, M.M., Hose, D., Goldschmidt, H., Jauch, A., Langer, C., Hegenbart, U., Schönland, S.O., Hemminki, K., 2014. Immunoglobulin light-chain amyloidosis shares genetic susceptibility with multiple myeloma. Leukemia 28, 2254–2256. http://doi.org/10.1038/leu.2014.208

Weinhold, N., Johnson, D.C., Rawstron, A.C., Försti, A., Doughty, C., Vijayakrishnan, J., Broderick, P., Dahir, N.B., Begum, D.B., Hosking, F.J., Yong, K., Walker, B.A., Hoffmann, P., Mühleisen, T.W., Langer, C., Dörner, E., Jöckel, K.-H., Eisele, L., Nöthen, M.M., Hose, D., Davies, F.E., Goldschmidt, H., Morgan, G.J., Hemminki, K., Houlston, R.S., 2014. Inherited genetic susceptibility to monoclonal gammopathy of unknown significance. Blood 123, 2513–2517; quiz 2593. http://doi.org/10.1182/blood-2013-10-532283

Whelan, R., Watts, R., Orr, C.A., Althoff, R.R., Artiges, E., Banaschewski, T., Barker, G.J., Bokde, A.L.W., Büchel, C., Carvalho, F.M., Conrod, P.J., Flor, H., Fauth-Bühler, M., Frouin, V., Gallinat, J., Gan, G., Gowland, P., Heinz, A., Ittermann, B., Lawrence, C., Mann, K., Martinot, J.-L., Nees, F., Ortiz, N., Paillère-Martinot, M.-L., Paus, T., Pausova, Z., Rietschel, M., Robbins, T.W., Smolka, M.N., Ströhle, A., Schumann, G., Garavan, H., IMAGEN Consortium, 2014. Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature 512, 185–189. http://doi.org/10.1038/nature13402

Witzenrath, M., 2014. Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff! Am. J. Respir. Crit. Care Med. 189, 1452–1455. http://doi.org/10.1164/rccm.201405-0827ED

Zhao, G., Dharmadhikari, G., Maedler, K., Meyer-Hermann, M., 2014. Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies. PLoS Comput. Biol. 10, e1003798. http://doi.org/10.1371/journal.pcbi.1003798

 

2013

Chubb, D., Weinhold, N., Broderick, P., Chen, B., Johnson, D.C., Försti, A., Vijayakrishnan, J., Migliorini, G., Dobbins, S.E., Holroyd, A., Hose, D., Walker, B.A., Davies, F.E., Gregory, W.A., Jackson, G.H., Irving, J.A., Pratt, G., Fegan, C., Fenton, J.A.L., Neben, K., Hoffmann, P., Nöthen, M.M., Mühleisen, T.W., Eisele, L., Ross, F.M., Straka, C., Einsele, H., Langer, C., Dörner, E., Allan, J.M., Jauch, A., Morgan, G.J., Hemminki, K., Houlston, R.S., Goldschmidt, H., 2013. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat. Genet. 45, 1221–1225. https://doi.org/10.1038/ng.2733

Kempf, H., Hatzikirou, H., Bleicher, M., Meyer-Hermann, M., 2013. In silico analysis of cell cycle synchronisation effects in radiotherapy of tumour spheroids. PLoS Comput. Biol. 9, e1003295. https://doi.org/10.1371/journal.pcbi.1003295

Moehler, T.M., Seckinger, A., Hose, D., Andrulis, M., Moreaux, J., Hielscher, T., Willhauck-Fleckenstein, M., Merling, A., Bertsch, U., Jauch, A., Goldschmidt, H., Klein, B., Schwartz-Albiez, R., 2013. The glycome of normal and malignant plasma cells. PLoS ONE 8, e83719. https://doi.org/10.1371/journal.pone.0083719

Spanagel, R., Durstewitz, D., Hansson, A., Heinz, A., Kiefer, F., Köhr, G., Matthäus, F., Nöthen, M.M., Noori, H.R., Obermayer, K., Rietschel, M., Schloss, P., Scholz, H., Schumann, G., Smolka, M., Sommer, W., Vengeliene, V., Walter, H., Wurst, W., Zimmermann, U.S., Addiction GWAS Resource Group, Stringer, S., Smits, Y., Derks, E.M., 2013. A systems medicine research approach for studying alcohol addiction. Addict Biol 18, 883–896. https://doi.org/10.1111/adb.12109

Publications of the individual e:Med research alliances can be found directly on their project pages:
Consortia - Demonstrators - Young Investigators