Dopaminergic signaling and sensory prediction in genetic mouse models of schizophrenia
The goal of subproject 3 is to understand how dopamine neurons contribute to sensory prediction and how genetic mutations, that increase the risk for schizophrenia, influence dopaminergic signalling and sensory prediction. To this end, we will measure neural activity in mice while they experience predictable sensory stimuli, as in subprojects 1 and 2. Dopaminergic neurons will be identified and their activity manipulated using optogenetic methods, in order to reveal their influence on sensory areas of the brain. The neuronal measurements will be carried out both in normal wild-type mice as well as in genetically modified schizophrenia mouse models. These mice carry genetic mutations that in humans constitute risk factors for schizophrenia.