Comparison of central metabolic routes and signaling pathways in IDH mutant and wildtype gliomas

Malignant gliomas belong to the most feared types of cancer, due to their dismal prognosis, as well as direct consequences on cognitive function and quality of life. GlioPATH is an interdisciplinary (biomedical, theoretical, clinical) and synergistic team effort. Iterative computational-experimental approaches will establish a network structure linking signalling and metabolic pathways by integrating several existing data layers (transcriptomics, proteomics, epigenetic, clinical) with metabolomic and kinetic biochemical analyses of glioma tissues. GlioPATH will enable an improved understandingof glioma progession and provide the basis to identify possible combinatorial intervention strategies for individualized glioma therapy.