SYMBOL-HF

Publications

2020

Diofano, F., Weinmann, K., Schneider, I., Thiessen, K. D., Rottbauer, W. and Just, S. (2020). "Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency." PLoS genetics 16(11): 24. www.ncbi.nlm.nih.gov/pubmed/33137814.

Pott, A., Rottbauer, W. and Just, S. (2020). "Streamlining drug discovery assays for cardiovascular disease using zebrafish." Expert Opinion on Drug Discovery 15(1): 27-37. www.ncbi.nlm.nih.gov/pubmed/31570020.

Rangrez, A. Y., Kilian, L., Stiebeling, K., Dittmann, S., Yadav, P., Schulze-Bahr, E., Frey, N. and Frank, D. (2020). "Data on the role of cardiac α-actin (ACTC1) gene mutations on SRF-signaling." Data in Brief 28: 105071. www.sciencedirect.com/science/article/pii/S2352340919314271.

2019

Frank, D., Yusuf Rangrez, A., Friedrich, C., Dittmann, S., Stallmeyer, B., Yadav, P., Bernt, A., Schulze-Bahr, E., Borlepawar, A., Zimmermann, W. H., Peischard, S., Seebohm, G., Linke, W. A., Baba, H. A., Kruger, M., Unger, A., Usinger, P., Frey, N. and Schulze-Bahr, E. (2019). "Cardiac alpha-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy." Circ Genom Precis Med 12(8): e002491. www.ncbi.nlm.nih.gov/pubmed/31430208.

Gramlich, M., Maleck, C., Marquardt, J., Duckheim, M., Stimpfle, F., Heinzmann, D., Scheckenbach, C., Gawaz, M., Schreieck, J. and Seizer, P. (2019). "Cryoballoon ablation for persistent atrial fibrillation in patients without left atrial fibrosis." J Cardiovasc Electrophysiol. www.ncbi.nlm.nih.gov/pubmed/30938897.

Gross, A., Kracher, B., Kraus, J. M., Kuhlwein, S. D., Pfister, A. S., Wiese, S., Luckert, K., Potz, O., Joos, T., Van Daele, D., De Raedt, L., Kuhl, M. and Kestler, H. A. (2019). "Representing dynamic biological networks with multi-scale probabilistic models." Commun Biol 2: 21. www.ncbi.nlm.nih.gov/pubmed/30675519.

Hahn, J. K., Neupane, B., Pradhan, K., Zhou, Q., Testa, L., Pelzl, L., Maleck, C., Gawaz, M. and Gramlich, M. (2019). "The assembly and evaluation of antisense oligonucleotides applied in exon skipping for titin-based mutations in dilated cardiomyopathy." J Mol Cell Cardiol 131: 12-19. www.ncbi.nlm.nih.gov/pubmed/30998980.

Kluge, A., Rangrez, A. Y., Kilian, L. S., Pott, J., Bernt, A., Frauen, R., Rohrbeck, A., Frey, N. and Frank, D. (2019). "Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy." J Mol Cell Cardiol 129: 130-143. www.ncbi.nlm.nih.gov/pubmed/30797814.

Lausser, L., Schafer, L. M., Schirra, L. R., Szekely, R., Schmid, F. and Kestler, H. A. (2019). "Assessing phenotype order in molecular data." Sci Rep 9(1): 11746. www.ncbi.nlm.nih.gov/pubmed/31409831.

Rangrez, A. Y., Kilian, L., Stiebeling, K., Dittmann, S., Schulze-Bahr, E., Frey, N. and Frank, D. (2019). "A cardiac alpha-actin (ACTC1) p. Gly247Asp mutation inhibits SRF-signaling in vitro in neonatal rat cardiomyocytes." Biochem Biophys Res Commun 518(3): 500-505. www.ncbi.nlm.nih.gov/pubmed/31434612.

2018

Brockmann, S. J., Freischmidt, A., Oeckl, P., Müller, K., Ponna, S. K., Helferich, A. M., Paone, C., Reinders, J., Kojer, K., Orth, M., Jokela, M., Auranen, M., Udd, B., Hermann, A., Danzer, K. M., Lichtner, P., Walther, P., Ludolph, A. C., Andersen, P. M., Otto, M., Kursula, P., Just, S. and Weishaupt, J. H. (2018). "CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency." Human Molecular Genetics 27(4): 706-715. www.ncbi.nlm.nih.gov/pubmed/29315381.

Helferich, A. M., Brockmann, S. J., Reinders, J., Deshpande, D., Holzmann, K., Brenner, D., Andersen, P. M., Petri, S., Thal, D. R., Michaelis, J., Otto, M., Just, S., Ludolph, A. C., Danzer, K. M., Freischmidt, A. and Weishaupt, J. H. (2018). "Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS." Cellular and molecular life sciences: CMLS 75(23): 4301-4319. www.ncbi.nlm.nih.gov/pubmed/30030593.

Hühne, R., Kessler, V., Fürstberger, A., Kühlwein, S., Platzer, M., Sühnel, J., Lausser, L. and Kestler, H. A. (2018). "3D Network exploration and visualisation for lifespan data." BMC Bioinformatics 19(1): 390. doi.org/10.1186/s12859-018-2393-x

Keßler, M., Kieltsch, A., Kayvanpour, E., Katus, H. A., Schoser, B., Schessl, J., Just, S. and Rottbauer, W. (2018). "A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations." Neuromuscular disorders: NMD 28(6): 521-531. www.ncbi.nlm.nih.gov/pubmed/29735270.

Kramer, F., Just, S. and Zeller, T. (2018). "New perspectives: systems medicine in cardiovascular disease." BMC systems biology 12(1): 57. www.ncbi.nlm.nih.gov/pubmed/29699591.

Kramer, L. M., Brettschneider, J., Lennerz, J. K., Walcher, D., Fang, L., Rosenbohm, A., Balakrishnan, K., Benckendorff, J., Moller, P., Just, S., Willem, M., Ludolph, A. C. and Thal, D. R. (2018). "Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis." Sci Rep 8(1): 16594. www.ncbi.nlm.nih.gov/pubmed/30413735.

Kraus, J. M., Lausser, L., Kuhn, P., Jobst, F., Bock, M., Halanke, C., Hummel, M., Heuschmann, P. and Kestler, H. A. (2018). "Big data and precision medicine: challenges and strategies with healthcare data." International Journal of Data Science and Analytics: 1-9. link.springer.com/article/10.1007/s41060-018-0095-0

Kustermann, M., Manta, L., Paone, C., Kustermann, J., Lausser, L., Wiesner, C., Eichinger, L., Clemen, C. S., Schröder, R., Kestler, H. A., Sandri, M., Rottbauer, W. and Just, S. (2018). "Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo." Autophagy. www.ncbi.nlm.nih.gov/pubmed/30010465.

Lausser, L., Siegle, L., Rottbauer, W., Frank, D., Just, S. and Kestler, H. A. (2018). "Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species." Biomolecules 8(4). www.ncbi.nlm.nih.gov/pubmed/30486323.

Neupane, B., Zhou, Q., Gawaz, M. and Gramlich, M. (2018). "Personalized medicine in inflammatory cardiomyopathy." Personalized Medicine 15(2): 127-136. www.futuremedicine.com/doi/abs/10.2217/pme-2017-0074.

Paone, C., Diofano, F., Park, D.-D., Rottbauer, W. and Just, S. (2018). "Genetics of Cardiovascular Disease: Fishing for Causality." Frontiers in Cardiovascular Medicine 5. www.ncbi.nlm.nih.gov/pubmed/29911105.

Paone, C., Rudeck, S., Etard, C., Strähle, U., Rottbauer, W. and Just, S. (2018). "Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response." Biochemical and Biophysical Research Communications 496(2): 339-345. www.ncbi.nlm.nih.gov/pubmed/29331378.

Pott, A., Bock, S., Berger, I. M., Frese, K., Dahme, T., Keßler, M., Rinné, S., Decher, N., Just, S. and Rottbauer, W. (2018). "Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish." Journal of Molecular and Cellular Cardiology 120: 42-52. www.ncbi.nlm.nih.gov/pubmed/29750993.

Pott, A. and Just, S. (2018). "Metabolic Profiling of Glucocorticoid Deficiency: A "Fishing" Expedition." EBioMedicine 37: 27-28. www.ncbi.nlm.nih.gov/pubmed/30389507.

Pott, A., Shahid, M., Köhler, D., Pylatiuk, C., Weinmann, K., Just, S. and Rottbauer, W. (2018). "Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish." Biomolecules 8(4). www.ncbi.nlm.nih.gov/pubmed/30463267.

Schwab, J. D. and Kestler, H. A. (2018). "Automatic Screening for Perturbations in Boolean Networks." Frontiers in Physiology 9: 431. www.ncbi.nlm.nih.gov/pubmed/29740342.

Segert, J., Schneider, I., Berger, I. M., Rottbauer, W. and Just, S. (2018). "Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish." Progress in Biophysics and Molecular Biology 138: 20-31. www.ncbi.nlm.nih.gov/pubmed/30036562.

Siegle, L., Schwab, J. D., Kühlwein, S. D., Lausser, L., Tümpel, S., Pfister, A. S., Kühl, M. and Kestler, H. A. (2018). "A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells." PloS One 13(3): e0195126. www.ncbi.nlm.nih.gov/pubmed/29596489.

Silbernagel, N., Walecki, M., Schäfer, M. K. H., Kessler, M., Zobeiri, M., Rinné, S., Kiper, A. K., Komadowski, M. A., Vowinkel, K. S., Wemhöner, K., Fortmüller, L., Schewe, M., Dolga, A. M., Scekic-Zahirovic, J., Matschke, L. A., Culmsee, C., Baukrowitz, T., Monassier, L., Ullrich, N. D., Dupuis, L., Just, S., Budde, T., Fabritz, L. and Decher, N. (2018). "The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function." FASEB journal www.ncbi.nlm.nih.gov/pubmed/29879376.

Zhou, Q., Maleck, C., von Ungern-Sternberg, S. N. I., Neupane, B., Heinzmann, D., Marquardt, J., Duckheim, M., Scheckenbach, C., Stimpfle, F., Gawaz, M., Schreieck, J., Seizer, P. and Gramlich, M. (2018). "Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation." Circulation. Arrhythmia and Electrophysiology 11(6): e006242. www.ncbi.nlm.nih.gov/pubmed/29848477.

2017

Lausser, L., Szekely, R., Schirra, L.-R., Kestler, H.A., 2017. The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes. Neural Process Lett 1–18. doi.org/10.1007/s11063-017-9706-3

Meyer, P., Maity, P., Burkovski, A., Schwab, J., Müssel, C., Singh, K., Ferreira, F.F., Krug, L., Maier, H.J., Wlaschek, M., Wirth, T., Kestler, H.A., Scharffetter-Kochanek, K., 2017. A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence. PLoS Comput. Biol. 13, e1005741. doi.org/10.1371/journal.pcbi.1005741

Rangrez, A.Y., Hoppe, P., Kuhn, C., Zille, E., Frank, J., Frey, N., Frank, D., 2017a. MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2. PLoS ONE 12, e0183901. doi.org/10.1371/journal.pone.0183901

Rangrez, A.Y., Pott, J., Kluge, A., Frauen, R., Stiebeling, K., Hoppe, P., Sossalla, S., Frey, N., Frank, D., 2017b. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochim. Biophys. Acta 1864, 634–644. doi.org/10.1016/j.bbamcr.2017.01.004

Schwab, J., Burkovski, A., Siegle, L., Müssel, C., Kestler, H.A., 2017. ViSiBooL-visualization and simulation of Boolean networks with temporal constraints. Bioinformatics 33, 601–604. doi.org/10.1093/bioinformatics/btw661

Zhou, Q., Schötterl, S., Backes, D., Brunner, E., Hahn, J.K., Ionesi, E., Aidery, P., Sticht, C., Labeit, S., Kandolf, R., Gawaz, M., Gramlich, M., 2017. Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy. Int. J. Cardiol. 230, 634–641. doi.org/10.1016/j.ijcard.2016.12.171

2016

Bühler, A., Kustermann, M., Bummer, T., Rottbauer, W., Sandri, M., Just, S., 2016. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci 17. doi.org/10.3390/ijms17020187

Hirth, S., Bühler, A., Bührdel, J.B., Rudeck, S., Dahme, T., Rottbauer, W., Just, S., 2016. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE 11, e0150323. doi.org/10.1371/journal.pone.0150323

Hoffmann, S., Clauss, S., Berger, I.M., Weiß, B., Montalbano, A., Röth, R., Bucher, M., Klier, I., Wakili, R., Seitz, H., Schulze-Bahr, E., Katus, H.A., Flachsbart, F., Nebel, A., Guenther, S.P., Bagaev, E., Rottbauer, W., Kääb, S., Just, S., Rappold, G.A., 2016. Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. Basic Res. Cardiol. 111, 36. doi.org/10.1007/s00395-016-0557-2

Just, S., Hirth, S., Berger, I.M., Fishman, M.C., Rottbauer, W., 2016a. The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation. Biochem. Biophys. Res. Commun. 477, 581–588. doi.org/10.1016/j.bbrc.2016.06.088

Just, S., Raphel, L., Berger, I.M., Bühler, A., Keßler, M., Rottbauer, W., 2016b. Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. PLoS ONE 11, e0167306. doi.org/10.1371/journal.pone.0167306

Lausser, L., Schmid, F., Schirra, L.-R., Wilhelm, A.F.X., Kestler, H.A., 2016. Rank-based classifiers for extremely high-dimensional gene expression data. Adv Data Anal Classif 1–20. doi.org/10.1007/s11634-016-0277-3


2015

Keßler, M., Rottbauer, W., Just, S., 2015. Recent progress in the use of zebrafish for novel cardiac drug discovery. Expert Opin Drug Discov 10, 1231–1241. https://doi.org/10.1517/17460441.2015.1078788

 

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