SP6 - InCa

Interaction between tumor evolution and its microenvironment

Cancer genomes are characterized by accumulating more and more genomic changes (mutations, copy number changes, and translocations) over time. From this it follows that cancer genomes are in a constant evolutionary process, which in turn can lead to resistance to therapy. The overall goal of this subproject is to decipher the interplay between tumor evolution and its tumor microenvironment (TME) in non-small cell lung cancer (NSCLC). For this purpose, single-cell sequencing data are integrated with conventional bulk tumor analysis data. The data integration includes data from the other sub-projects in order to link them to a comprehensive model. Therefore we will create a platform for all data analysis and in-silico modelling, which is available to the whole consortium.