Speaker

Please note, all speakers are to be re-confirmed for the virtual event.

Welcome Talks:

Eva Nourney, MinR'in

© Eva Nourney

Welcome Talk

Eva Nourney heads the Unit New Methods and Technologies in the Life Sciences at the German Federal Ministry for Education and Research in Berlin.
Ms Nourney is a lawyer by training, originally specialising in International and EU-Law. She joined the German Federal Civil Service in 2000, starting at the Ministry for Consumer Protection and Agriculture. In 2002, she was appointed to the Federal Chancellery (Bundeskanzleramt), specializing in strategic development of education and research policy. In 2008, Ms Nourney transferred to the Federal Ministry for Education and Research, where she has since headed various units in the area of research and innovation policy. Since 2017 her work within the Ministry concentrates on Digitalisation and the Life Sciences.
www.bmbf.de

Talk: Sunday, March 8, Session: Welcome Speech, 03:30 - 04:00 pm

Keynote Talks:

Julie George

© Julie George

Keynote Speaker

Department of Translational Genomics, University of Cologne

Talk: Tuesday, March 10, Session: Translational Systems Medicine, 2:00 - 02:30 pm

Martin Hirst

© Hirst

Keynote Speaker

Dr. Hirst is an Associate Professor in the Department of Microbiology and Immunology, Associate Director of the Michael Smith Laboratories at the University of British Columbia (UBC) and Head of Epigenomics at Canada’s Michael Smith Genome Sciences Centre. Dr. Hirst was one of the first in the world to successfully complete ChIP-seq, RNA-seq and miRNA-seq experiments on the nascent Solexa 1G platform and for the last 10 years he has led the development of an internationally recognized epigenomic research program at UBC and BC Cancer. As a member of the NIH Human Reference Epigenomic Mapping Consortium, he led the development of epigenomic analysis tools for comprehensive molecular profiling of human tissues and cells. He currently leads the Centre of Epigenomic Mapping Technologies (CEMT) that represents one of two Canadian epigenomic mapping centres funded as part of the CIHR signature initiative; the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC). Dr. Hirst currently chairs the Scientific Steering Committee of the International Human Epigenome Consortium (IHEC; ihec.org) and leads the Canadian Epigenetics, Environment and Health Research Consortium Network (epigenomes.ca) with a mandate to drive epigenetic research in Canada and internationally.

Dr. Hirst is a highly cited researcher (2019) whose work focuses on understanding the role of epigenetic deregulation in cancer. To enable tracking and epigenomic profiling of rare subsets of normal and transformed cell types he recently developed a genomic barcoding strategy, a native ChIP-seq protocol, and a PBAT methodology for profiling DNA methylation genome wide down to a single cell level. He has applied these and other tools to explore the epigenomic states of highly-purified and functionally defined normal and transformed cell types including the characterization of vitamin C induced epigenomic reprograming in leukemic models.

Visionary Talk: Epigenetically driven enhanceropathies in cancer genomes,
Sunday, March 08, 4:00 - 4:45 pm

Peter Krawitz

© Krawitz

Keynote Speaker

Peter Krawitz studied medicine and physics in Munich, Germany. After theoretical work on Boolean networks at the institute of Systemsbiology in Seattle, he continued with a postdoc at the Max Planck Institute for Molecular Genetics in Berlin. Also in Berlin, he got board certified for Medical Genetics at Charité University medicine. In 2017 he established the Institute for Genomic Statistics and Bioinformatics at University Bonn, where he develops phenotype driven approaches for variant interpretation.

Talk: Monday, March 09, Session: Molecular Medicine Board, 10:45 - 11:45 am

Dagmar Kulms

© Kulms

Keynote Speaker

Dr. Kulms studied Biology at the University of Gießen, Germany and became a PhD in the field of protein biochemistry at the Medical University of Lübeck, Germany. Changing subjects as a postdoc she moved to the Laboratory of Cell Biology, Department of Dermatology, University of Münster, Germany, staring to investigate the adverse effects of UVB radiation on human skin. She received the Venia Legendi for „Molecular and Cellular Biology“ in 2003. In 2004 she became an Assistant Professor and Group Leader of „Molecular and Cellular Biology“ at the Institute of Cell Biology and Immunology at the University of Stuttgart, Germany, and continued her work on skin cancer shifting the focus on melanoma. In 2006 she started first collaborations with Systems Biology groups. In 2012 she founded the research group of „Experimental Dermatology“ at the Department of Dermatology, Technical University of Dresden, Germany, and was assigned a Professor of Experimental Dermatology in 2015. Her collaborative work with Systems Biology Groups focusses on the identification of new therapeutic targets and in the development of advanced patients stratification tools.

Talk: Monday, March 09, 2:15 - 2:45 pm

Joachim Schultze

© Schultze

Keynote Speaker

Dr. Schultze is Professor for Genomics & Immunoregulation at the Life and Medical Sciences (LIMES)-Institute since 2007 and Founding Director of the PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn since 2016. He went to Medical School at the University of Tübingen, spent almost 10 years at Dana-Farber Cancer Institute, Harvard Medical School, in Boston before he returned to Germany with a Sofia Kovalevskaya Award of the Humboldt Foundation in 2001. Since 2019, he is the coordinator of the German DFG-funded NGS competence centers in Germany, one of the speakers of the West German Genome Center, and one of the speakers of the only German Excellence Cluster in Immunology: ImmunoSensation2. He contributes his expertise to several EU consortia, amongst them SYSCID. He is a highly cited researcher (2019) and an expert in macrophage biology working at the interphase between immunology, genomics and the computational sciences. With his team he was the first to apply memory driven computing to genomics research. With his own research group and the PRECISE platform, his goal is to bring single cell technologies and machine learning approaches to the clinical arena. He is leading several programs on applying single cell technologies and memory driven computing to patients with Alzheimer’s disease, chronic obstructive pulmonary disease, lung cancer or HIV. He has established research collaborations with HPE, AstraZeneca, Boehringer Ingelheim, Becton Dickinson and other companies.

Talk: Tuesday, March 10, Session: Systems Medicine of Diseases, 8:30 - 9:00 am

Heribert Schunkert

© Schunkert

Keynote Speaker

Heribert Schunkert, MD is Professor of Cardiology of the Technische Universität München and Director of the Cardiology Department, German Heart Centre Munich since 2012. He completed a research fellowship at Brigham and Women’s Hospital, Boston, USA and clinical fellowships at Beth Israel Hospital, Universitätsklinikum Regensburg, and the Massachusetts General Hospital, Boston, USA, before he became assistant and associate professor in Regensburg. From 2002-2012 Prof. Schunkert was Director of Internal Medicine and Cardiology at the University of Luebeck. He conducts research in the molecular genetics of multifactorial cardiovascular disease, coordinates several EU- and BMBF-sponsored projects as well as the European-American Leducq network CADgenomics to identify the genetic roots of myocardial infarction. He is the author of more than 600 publications in international journals.

Talk: Monday, March 09, 8:30 - 9:00 am

Fabian Theis

© Fabian Theis

Keynote Speaker

Fabian Theis is director of the Institute of Computational Biology at the Helmholtz Center Munich and coordinates the Helmholtz Artificial Intelligence Cooperation Unit (HAICU) which was launched in 2019. He is full professor at the Technical University of Munich, holding the chair ‘Mathematical Modelling of Biological Systems’. During his academic career Fabian Theis obtained MSc degrees in Mathematics and Physics at the University of Regensburg in 2000. He received a PhD degree in Physics from the same university in 2002 and a PhD in Computer Science from the University of Granada in 2003. He worked as visiting researcher at the department of Architecture and Computer Technology (University of Granada, Spain), at the RIKEN Brain Science Institute (Wako, Japan), at FAMU-FSU (Florida State University, USA) and at TUAT’s Laboratory for Signal and Image Processing (Tokyo, Japan), and headed the ‘signal processing & information theory’ group at the Institute of Biophysics (Regensburg, Germany). In 2006, he started working as Bernstein fellow leading a junior research group at the Bernstein Center for Computational Neuroscience, located at the Max Planck Institute for Dynamics and Self-Organisation at Göttingen. In summer 2007, Fabian Theis became working group head of CMB at the Institute of Bioinformatics at the Helmholtz Center Munich. In spring 2009, he became associate Professor for Mathematics in Systems Biology at the Math Department of the TU Munich. 2009-2014 he was member of the ‘Young Academy’ (founded by the Berlin-Brandenburg Academy of Sciences and Humanities and the German Academy of Natural Scientists Leopoldina) and was awarded an ERC starting grant in 2010.
In 2017 he was awarded the Erwin Schrödinger prize together within an interdisciplinary team at the ETH Zürich. Fabian Theis is part of and also coordinates various consortia (i.e. sparse2big involving 8 Helmholtz Centers) and founded the network SingleCellOmics Germany (SCOG). Furthermore he coordinates the recently launched Munich School for Data Science (MUDS). Since 2019 he is associate faculty at the Wellcome Trust Sanger Institute, Hinxton, UK and member of the European Laboratory for Learning and Intelligent Systems (ELLIS). His research interests include development of computational methods for analyzing and modelling single cell heterogeneities as well as machine and deep learning for prediction in biology and biomedicine.

Talk: Tuesday, March 10, Session: Modelling & Technologies in Systems Medicine, 10:45 - 11:15 am

Selected Abstracts:

Saikat Banerjee

© Banerjee

Saikat is currently a PostDoc in Quantitative and Computational Biology group at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany working with Dr. Johannes Söding since 2015. He completed his PhD at the Indian Institute of Science, Bengaluru working on statistical physics. His main focus is to develop novel statistical methodology, often with Bayesian approach and non-trivial computational component, for elucidating and understanding the pathway of complex diseases using data from genetic association studies, RNA-seq and gene expression analyses. Along with his colleagues, he has developed a Bayesian method for finemapping genetic variants from multiple GWAS datasets. He is currently in the process of authoring a publication for large-scale discovery of trans-eQTLs from the GTEx data, linking several GWAS-associated non-coding variants to known and novel disease mechanisms.

Talk: Tuesday, March 10, Session: Modeling & Technologies in Systems Medicine, 11:30 - 11:45 am

Joana P Bernardes

© Bernardes

I am currently a Postdoc in Systems Immunology Group at Institute of Clinical Molecular Biology (Kiel) lead by Prof. MD Philip Rosenstiel. My main focus area is in precision therapy in IBD where I use high-throughput technology to predict disease progression and treatment in patients affected by Crohn’s disease and ulcerative colitis. In my daily work I use our longitudinal human cohorts to disentangle disease patterns by comparing the patient’s molecular states before and after treatment with biologic drugs. Our aim is be analyzing and integrating OMIC layers from a variety of tissues (e.g. whole blood and ileum or sigmoid mucosal biopsies) can lead to the identification of a biomarker set that can be use within the clinical context. Our goal is to delineate drug-specific, together with shared mechanisms of mucosal healing in order to identify early signs of disease remission that could potentially be used in determining which treatment path is best suited for each patient.

Talk: Tuesday, March 10, Session: Systems Medicine of Diseases, 9:00 - 9:15 am

Sara Checa

© Checa

Sara achieved her degree in Mechanical Engineering at the University of Malaga (Spain) in 2003.  She then completed her PhD at the University of Southampton in finite element modeling of knee replacement devices. She has conducted post-doctoral research at the Trinity Center for Bioengineering in Ireland, at the Julius Wolff Institute in Germany and at Stanford University in the USA. She is currently Junior Professor and group leader at the Julius Wolff Institute, specializing in computer modeling of mechano-biological processes with a focus on bone regeneration and adaptation at the tissue and cellular scales. She is an author of more than 40 publications in peer-reviewed journals, several book chapters and more than 70 contributions to International and National Conferences.

Talk: Tuesday, March 10, Session: Modelling & Technologies in Systems Medicine, 11:45 - 12:00 pm

Arkadiusz Komorowski

© Komorowski

After finishing his medical studies in Austria, Dr.med. Arkadiusz Komorowski simultaneously engaged in research activities and gained first-hand clinical experiences as a resident doctor. Ever since, he is working at the research team “NeuroImaging Labs (NIL)” at the Department of Psychiatry and Psychotherapy of the Medical University of Vienna. In 2018, Dr.med. Komorowski visited the “Laboratory of Systems Neuroscience and Imaging in Psychiatry” at the Department of Psychiatry and Psychotherapy of the University Medical Center, Göttingen in order to extend his knowledge about neuroimaging research in depressive disorders. As a consequence, Dr.med. Komorowski is currently in the process of authoring a publication of the work that was realized during his research term in Germany to finalize his PhD project. Besides his interest in clinical neurosciences, he recently engaged in preventive human rights monitoring at the Austrian Ombudsman Board.

Talk: Tuesday, March 10, Session: Translational Systems Medicine, 2:45 - 3:00 pm

Mathias Reuss

© Reuss

Retired Professor, University of Stuttgart. 1976-1987 Professor for Biochemical Engineering and Director of the Institute of Biochemical Engineering, University Stuttgart, 2006-2014 Director of the Centre Systems Biology, University Stuttgart.

Talk: Tuesday, March 10, Session: Modelling & Technologies in Systems Medicine, 12:00 - 12:15 pm

Apurva Shrivastava

© Shrivastava

Second Year PhD student, Molecular Cardiology, Genomics and Systems Medicine at University Clinic, Hamburg under the supervision of Prof Dr Tanja Zeller. She received her Master's degree after studying Pharmaceutical Biotechnology at the Hamburg University. Her Master thesis focused on establishing a technological pipeline to study the role of microRNAs in atrial
fibrillation. This translational approach was part of the eMed symAtrial consortium and was carried out in the laboratory of Prof Zeller. Her Doctoral research investigates on iron metabolism, in particular, the molecular mechanisms underlying the improvement of symptoms upon iron supplementation in iron-deficient heart failure patients.

Talk: Tuesday, March 10, Session: Systems Medicine of Diseases, 9:15 - 9:30 am

Lucia Trastulla

© Trastulla

Lucia Trastulla is currently a PhD candidate at the Max Planck Institute of Psychiatry in Munich enrolled at the TUM (technische universität münchen) Medical Graduate Center in the Experimental Medicine Program. Since September 2016 she is working as a PhD student in the lab for Genomics of Complex Diseases of the research group leader Dr. Michael Ziller.
Her research project mainly focuses on understanding how genetics and epigenetics mechanism contribute to the etiology of complex diseases such as schizophrenia and coronary artery disease using machine learning techniques.
From 2014 to 2016 she pursued her master degree in Applied Mathematics for Data Science at the University of Trento. Her master thesis was conducted during an internship at Fondazione Bruno Kessler in Trento in the research unit "Predictive Models for Biomedicine and Environment” focusing on integration techniques for high-throughput omics data.
From 2011 to 2014 she completed her bachelor degree in Mathematics at the University of Perugia with final dissertation on “Fujita and Louville results for parabolic problems”.

Talk: Tuesday, March 10, Session: Modelling & Technologies in Systems Medicine, 11:15 - 11:30 am

Olga Vvedenskaya

© Vvedenskaya

Dr. Olga Vvedenskaya, a clinical researcher, focuses her research on translational medicine and multi-omics approaches in disease research. She studied medicine in Moscow, majoring in medical biophysics. As a predoctoral fellow at the University of Pittsburgh, USA, she investigated the role of oxidized lipids in the development of traumatic brain injury. During her PhD in Berlin she worked on proteomic, metabolomic, and genomic analysis of human liver cancer, comparing samples of cancer conditions with mult-iomics data integration and visualization. Currently Olga is a postdoctoral researcher at the Max Planck Institute of Molecular Cell Biology (MPI-CBG), Dresden, and a member of Liver Systems Medicine Network, working on clinical lipidomics of NAFLD and NASH.

Talk: Tuesday, March 10, Session: Systems Medicine of Diseases, 9:30 - 9:45 am

Stefan Wiemann

© Wiemann

Professor and Head
Division Molecular Genome Analysis
Genomics and Proteomics Core Facility
German Cancer Research Center
Heidelberg, Germany

Stefan Wiemann earned his PhD in molecular biology from the University of Kaiserslautern. He was visiting scientist at the European Molecular Biology Laboratory, where he contributed to the genome sequencing of the first eukaryote (S.cerevisiae) as well as to the development of automated sequencing technologies. He then joined the DKFZ to set up a pipeline for the systematic identification and analysis of human genes. He coordinated the German cDNA Consortium, the largest initiative in Europe for the cloning of human genes. Since 2008 he has been head of the division Molecular Genome Analysis and as of 2010 also of the Genomics and Proteomics Core Facility of the DKFZ. He has led large research networks in national programs of the Federal Ministry of Education and Research (BMBF), and is partner in national and international consortia. He has co-authored more than 170 scientific publications, is section editor for BMC Genomics, and associate editor for Scientific Data.

Talk: Tuesday, March 10, Session: Translational Approaches in Systems Medicine, 2:30 - 2:45 pm

New e:Med Projects:

Konrad Aden

© Aden

Dr. med. Konrad Aden is heading the junior research group “Immunometabolism of intestinal inflammation” at the Institute of Clinical Molecular Biology and works as a senior clinician scientist at the Department of Gastroenterology at the University Hospital Schleswig Holstein, Campus Kiel. He studies medicine in Kiel, Bern and St. Louis and obtained his MD degree in 2010 (University of Kiel) and his board certificate for “internal medicine and gastroenterology” in 2018. His research focuses on the pathophysiology of inflammatory bowel disease (IBD) and combines basic science and translational multi-omics analysis of patient cohorts. He main interest lays in the understanding of therapy response prediction towards multiple targeted therapies in IBD. Within e:MED he contributes to the clinical demonstrator “GUIDE-IBD”, focusing on individualized therapy guidance of IBD patients. He further coordinates the Junior Research Alliance “Try-IBD”, aiming to provide a multi-dimensional resolution on the role of tryptophan metabolism in the pathogenesis of IBD. 

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 3:15 - 3:25 pm

Katarzyna Bozek

© Bozek

Trained as a computer scientist, my research is in computational biology. I completed my PhD at the Max Planck Institute for Computer Science in Saarbrücken in the group of Thomas Lengauer. In my thesis I used machine learning, statistical, and algorithmic methods to study HIV drug resistance and host adaptation mechanisms. I spent my postdoc time at the MPGCAS Partner Institute for Computational Biology in Shanghai in the group of Philipp Khaitovitch where I worked on human evolution. I implemented methods to search for uniquely human molecular features within large and heterogenous biological datasets. Most recently I worked at the Okinawa Institute of Science and Technology in Japan where I became interested in deep learning methods for image analysis. In my future research I aim to adopt this new set of machine learning methods to allow for broader, systems biology use of image data in biomedical research.

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 02:55 - 03:05 pm

Ivan Costa

© Costa

Ivan G. Costa is Professor for Computational Genomics at the RWTH Aachen Medical Faculty. After graduating in computer science in 2003 at the Federal University of Pernambuco (Brazil), he joined the Max Planck Institute for Molecular Genetics (Germany) to pursue doctoral studies in bioinformatics. His research interest involves statistical machine learning approaches to dissect transcriptional and regulatory programs controlling cellular changes in cell differentiation and in the onset of diseases as fibrosis and type II diabetes. He currently emphasis on computational methods to understand how cellular microenvironment changes cause or support disease processes by integrative analysis of transcriptional, chromatin and spatial status of single cells.

Talk: Monday, March 09, Session: New Projects in Systems Medicine II, 9:10 - 9:20 am

Stefan Florian

© Florian

I am currently a resident in pathology and group leader at the Institute of Pathology of Charité University Hospital in Berlin. I studied medicine at the Medical Universities of Vienna and Innsbruck, Austria. My thesis with Peter Valent in the Department of Hematology and Hemostaseology at the Vienna General Hospital (AKH) focused on leukemic stem cells and the biological mechanisms behind the development of mastocytosis. Then, for my PhD, I moved to Germany to join the lab of Thomas U. Mayer at the MPI of Biochemistry, Martinsried, and then University of Konstanz. Here I used small molecules and RNAi to understand how molecular motors and microtubules interact to form the mitotic spindle. During my postdoc in the lab of Tim Mitchison in the Department of Systems Biology at Harvard Medical School, I developed new hypotheses that might explain the mechanism of action microtubule binding drugs like taxol against tumor cells and developed an organoid system that emulates the formation of benign human breast lesions in vitro. Since 2017, I have been a resident in pathology at Charité in Berlin. In my current research, l aim to combine my experience in medicine, systems biology and cell biology to develop new therapeutic strategies in solid tumors.

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 2:55 - 3:05 pm

Georg Fuellen

© Fuellen

Prof. Dr. Georg Fuellen, Dipl.-Inform., MSc (MIT), is the director of the Institute for Biostatistics and Informatics in Medicine and Aging Research at the Rostock University Medical Center since 2008.
The research group of Fuellen focuses on the bioinformatics analyses of aging processes, based on laboratory and expression data of humans, mice and nematodes. Ongoing EU / DFG projects are concerned with transcriptome and proteomic data of these species, for healthspan and embryonic development. Earlier and recently acquired BMBF projects are concerned with the aging of mitochondria (ROSAge), antifibrotic and antileukemic drugs (Mechanisms of Life, Antifibrotix), biomarkers for senotherapeutics (HeLiXbyS) and the comorbidity of ischemic stroke, pancreatic cancer and cellular senescence (SASKit). In collaboration with the Faculty of Arts we developed a generic definition of health and biological age (Aging & Disease, 2019).

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 3:05 - 3:15 pm

Simon Haas

© Haas

Cell Technology and Experimental Medicine (HI-STEM)
German Cancer Research Center (DKFZ)

Simon studied Molecular Cell Biology, Biochemistry and Molecular Biosciences at Heidelberg University, Imperial College London and the German Cancer Research Center (DKFZ). He received his PhD from DKFZ and Heidelberg University in 2016. Simon performed research at DKFZ, Massachusetts Institute of Technology (MIT) and Harvard. Since 2016, he is heading a research group at HI-STEM focusing on single-cell systems analyses of stem cells at the interface of hematopoiesis, immunology and cancer.

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 02:45 - 02:55 pm

Marcus Meinhardt

© Meinhardt

Marcus Meinhardt received his Diploma in Biotechnology with a specialization in neuropharmacology from the University of Applied Sciences Mannheim, Germany. He then completed his PhD at the Central Institute of Mental Health Mannheim, Germany, focusing on the glutamatergic system in alcohol dependence and its implications in different addiction rat models. For his Post-doc, Marcus gained experience in the pharmaceutical industry at AbbVie, Ludwigshafen, Germany in the neuroscience drug discovery and DMPK department. Marcus recently returned to the Central Institute of Mental Health to investigate the neurobiological basis of alcohol dependence on both a pre-clinical and clinical level within the Department of Molecular Neuroimaging and at the Institute of Psychopharmacology. His main research interests lie in the development of new treatment targets for alcohol use disorder.

Talk: Sunday, March 08, Session: New Projects in Systems Medicine, 4:45 - 4:55 pm

Patrina S.P. Poh

© Poh

Dr. Patrina S. P. Poh received her PhD in 2014 from the Queensland University of Technology, Australia. She is a biomedical engineer trained at the intersection of additive biomanufacturing technologies and bone tissue engineering. Between 2015 to 2018, she was a research fellow at the Technical University of Munich, partially funded by the Bavaria Research Foundation. Since 2019, she is an independent principal investigator at the Julius Wolff Institute, Charité-Universitätsmedizin Berlin. Currently, her research focuses on personalisation of scaffold-aided bone regenerative therapy driven by structural and mechanobiological principals while deciphering the underlying molecular mechanism. Dr Poh has been awarded numerous public funding and leads a global network of universities and industrial partners.

Talk: Monday, March 09, Session: New Projects in Systems Medicine II, 09:20 - 09:30 am

Agustin Rodriguez-Gonzalez

© Rodriguez-Gonzalez

I studied Biochemistry at University of Basque Country (1992–1997) and obtained my PhD (1998-2002) in the Spanish National Research Council (IIB-CSIC). I was employed as a Junior Scientist at the Department of R&D at Pharmamar Inc. (2003-2004). During 2004 I worked at the Pharmacy School of the University of Southern California (USC). In 2005 I was invited as scientist to the California Institute of Technology (Caltech), and during the following years I was a postdoctoral researcher (2005-2007) and later on an associate researcher (2007-2008) at Jonsson Comprehensive Cancer Center (JCCC) at University of California Los Angeles (UCLA). In 2009, I joined to DKFZ in a mixed position of postdoctoral researcher and project manager for LungSys consortium (2009-2015). In 2016-2017 I was employed by German Center for Lung Research (DZL), in the multidisciplinary group of Lung Carcinoma and later on by Institute of Physics of the University of Freiburg (2018-2019). Currently I am employed by DKFZ in a mixed position of postdoctoral researcher and project manager for NephrESA.

Talk: Sunday, March 08, Session: New Projects in Systems Medicine I, 5:15 - 5:25 pm

Philip Rosenstiel

© Rosenstiel

Philip Rosenstiel studied medicine in Kiel and Boston and graduated from Medical School in 2001. During his studies was awarded a research scholarship from the BMEP/Studienstiftung.  He spent this time at the laboratories of Patsy Nishina (Jackson Lab, Maine) and Jeffrey Isner (St. Elisabeth Medical Center, Tufts University) working on mouse genetics and gene therapy. His thesis focused on Angiotensin II as a novel neurotrophic factor in the CNS. After graduating he went to the Dept. of Internal Medicine in Kiel for training in Internal Medicine/Mucosal Immunology with Ulrich Fölsch and Stefan Schreiber. After a postdoc at the MPI of Molecular Genetics in Berlin, he became Associate Professor of Molecular Medicine in Kiel in 2007. Since 2016, he is Full Professor and Chair of Clinical Molecular Biology and Medicine at the Institute of Clinical Molecular Biology at the University Hospital Schleswig-Holstein.
His group focuses on mucosal immunology of inflammatory bowel disease (IBD with its two subentities Crohn´s disease and Ulcerative colitis). An impaired interaction of the immune system with the resident microbiome at the gut epithelial barrier has emerged as an explanatory model of how the environment shapes detrimental immune responses. Intestinal epithelial cells, which are a pivotal intermediate layer transmitting and licensing luminal information to the underlying migratory immune cells, are in the centre of the research questions. His research uses systems-oriented approaches and a wide range of technologies including single cell-based transcriptomics and epigenomics as well as bacterial functional genomic profiling.

 

Talk: Monday, March 09, Session: New Projects in Systems Medicine II, 9:40 - 9:50 am

Clemens Schmitt

© Schmitt

Clemens A. Schmitt, M.D., is a hematologist/oncologist (especially a lymphoma specialist) at the Charité – University Medical Center and the Max-Delbrück-Center for Molecular Medicine in Berlin, Germany, and directs the medical department of hematology/oncology at Kepler University, Linz, Austria. He has a long-standing record as a clinician scientist with a strong translational research background in lymphoma, cellular senescence and stem cell biology, for which he exploits transgenic and patient-derived xenograft mouse lymphoma models as well as multi-organ lymphoma biochips. His work has been published in journals like Nature, Cell, Nature Medicine and Cancer Cell. Moreover, he serves as the principal investigator in numerous clinical trials, including a multi-center 1st-line lymphoma trial that explores four different treatment modalities by obtaining re-biopsies acutely under and in the later course of therapy to determine molecular signatures of response. Clemens Schmitt also coordinates several collaborative research projects and is a member of numerous scientific steering committees and advisory boards.

Talk: Monday, March 09, Session: New Projects in Systems Medicine IV, 5:00 - 5:10 pm

Markus Scholz

© Scholz

Markus Scholz is Professor for Genetical Statistics and Biomathematical Modelling at the Institute of Medical Informatics, Statistics and Epidemiology of the Medical Faculty of the University of Leipzig. He is mathematician by training and received his PhD in 2002. Since then he worked in the field of biomathematical modelling of disease and therapy processes in cancer and infectious diseases and is already involved in a number of systems-medical research projects of the e:Med line of funding (HaematoSys, HaematoOPT, CAPSyS). Since 2008, he also works in the field of Genetical Statistics, multi-omics data analysis and causal inference and is responsible for the molecular-genetic research programs of several large epidemiologic and clinical cohorts such as LIFE and PROGRESS with atherosclerosis and infectious diseases as main foci. He is Co-PI of the LIFE-Heart study and responsible for the vascular research program in LIFE-Adult. Website: www.genstat.imise.uni-leipzig.de

Talk: Monday, March 09, Session: New Projects in Systems Medicine IV, 4:30 - 04:40 pm

Emanuel Schwarz

© Schwarz

Emanuel Schwarz is a research group leader for translational bioinformatics in psychiatry at the Central Institute of Mental Health in Mannheim, Germany. His work focusses on the development and application of advanced computational methods for integrative analysis of high-dimensional, multimodal data, in order to identify clinically-relevant biological signatures of mental illness. He has co-coordinated the FP7 project IMAging GEnetics for MENtal Disorders (IMAGEMEND), focused on the application of machine learning for identification of diagnostic and prognostic biomarkers of schizophrenia, bipolar disorder and ADHD. A particular research focus is the exploration of potentially transdiagnostic markers of patient subgroups, which may aid in predicting response to conventional and novel therapeutic interventions, and give insight into the biology underlying comorbidity. The latter objective is the core aim of the interdisciplinary e:Med project  COMMITMENT (COMorbidity Modeling via Integrative Transfer machine-learning in MENTal illness).

Talk: Sunday, March 09, Session: New Projects in Systems Medicine I, 4:55 - 5:05 pm

Michael Seifert

© Seifert

Dr. Seifert studied bioinformatics from 2001 to 2006 at the Martin Luther University Halle-Wittenberg (MLU) and did a diploma thesis at the Max Planck Institute for Molecular Genetics in Berlin. He continued his work on extensions of Hidden Markov Models for omics data analysis at the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) in Gatersleben from 2006 to 2012 and received a doctoral degree in bioinformatics in 2010 from the MLU. He worked as a visiting scientist at the École Normale Supérieure in Paris from 2011 to 2013 on computational epigenetics and moved to the Biotechnology Center (BIOTEC) of the TU Dresden in 2012 to work on network-based approaches for cancer data analysis. After a short postdoc in Cologne, he became head of the Bioinformatics Core Unit at the Institute for Medical Informatics and Biometry of the TU Dresden at the end of 2015. We support omics data analysis and perform own research projects in close collaboration with wet lab partners.

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 3:35 - 3:45 pm

Rainer Spanagel

© Spanagel

Rainer Spanagel studied biology at the Universities of Tübingen and Munich and pursued his early training in behavioural pharmacology and neurochemistry at the Max Planck Institute (MPI) in Martinsried. In 1990, he moved to the MPI of Psychiatry in Munich and became head of the addiction research group and was awarded a lectureship in Pharmacology and Toxicology. In 2000, he relocated to the Central Institute of Mental Health in Mannheim, a leading European institution for biological psychiatry, to become scientific director of the Institute of Psychopharmacology. Professor Spanagel has been awarded many scientific prizes, most notably the Sir Hans Krebs Award for his seminal gene x environment studies in rodents, the James B. Isaacson Award and the European Alcohol Research Award he received for his continuing achievements in alcohol research, and the Reinhardt Koselleck Award for innovation in neuroscience. He has published more than 315 articles, is Editor-in-Chief of Addiction Biology and coordinated several national and European activities on electronic medicine for addictions.

Talk: Monday, March 09, Session: New Projects in Systems Medicine II, 9:00 - 9:10 am

Roman Thomas

© Thomas

Roman Thomas has received his M.D. degree from the University of Cologne, Germany, in 2000. He has worked as a physician scientist with Jürgen Wolf and Volker Diehl at the University Hospital of Cologne. In 2004, he joined the Cancer Genome Project at the Broad Institute of M.I.T. and Harvard as a Postdoctoral Fellow with Matthew Meyerson, funded by a fellowship of the Deutsche Krebshilfe. In 2007 Roman Thomas returned to Cologne as a Principal Investigator at the Max-Planck Institute for Neurological Research in Cologne Germany. In 2012 Roman Thomas was appointed Full Professor of Translational Genomics at the University of Cologne. His scientific focus is on the characterization of cancer genome alterations in lung cancer and on the cell biology implications of such alterations. He has furthermore spearheaded efforts aimed at the translation of cancer genome findings into diagnostic as well as therapeutic applications.

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 3:25 - 3:35 pm

Florian Tran

© Tran

Since 2017, I am working as a physician in the Department for Internal Medicine I and a basic science researcher in the Systems Immunology Group at the Institute of Clinical Molecular Biology (IKMB), both at the University Medical Center Schleswig-Holstein (UKSH), Campus Kiel. In 2019, the new Clinician Scientist Program of the DFG Cluster of Excellence “Precision Medicine in Chronic Inflammation” (PMI) launched and allows me on one side to advance my clinical training; on the other side, I am able to work in depth on wet lab during protected periods, providing the optimal clinical research environment for me. My current research interests are (i) molecular guidance strategies in IBD therapy, (ii) rare and genetic gastrointestinal disorder like veoIBD and immunodeficiency syndromes, (iii) stem cell based IBD models and (iv) autophagy processes in epithelial homeostasis. Within eMed, I am together with Prof. Stefan Schreiber coordinating the demonstrator alliance “GUIDE-IBD”.

Talk: Monday, March 09, Session: New Projects in Systems Medicine II, 9:50 - 10:00 am

Julio Vera-González

© Vera-González

Julio Vera-González is Professor of Systems Tumor Immunology at the Department of Dermatology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg. His background is in Physics and his PhD was in the computational modelling of metabolic networks. He was post-doc in the first EU-funded project on computational systems biology. His expertise is in reconstruction, analysis and modeling of biochemical and cell-to-cell networks in human diseases. He develops methodologies to integrate database knowledge, bioinformatics algorithms and high throughput data into ncRNA enriched regulatory networks. His team is currently developing 2D and 3D hybrid, multi-level (molecular + cell-to-cell) models accounting for the interplay between immune, epithelial and other types of cells. He applies systems approaches to determine mechanisms of therapy in cancer, autoimmunity and neurodegeneration. Webpage: www.jveralab.net

Talk: Monday, March 09, Session: New Projects in Systems Medicine II, 9:30 - 9:40 am

Uwe Voelker

© Voelker

Uwe Völker is Professor for Functional Genomics at University Medicine Greifswald. He earned his PhD in Microbiology. After work as PostDoc in Germany and San Antonio, TX, he returned to Germany to become group leader at the Max-Planck-Institute for terrestrial Microbiology and the University Marburg, where he used functional genomics technologies, particularly proteomics, to study bacterial adaptation reactions to environmental insults. In 2002 he joined University Medicine Greifswald as Associated Professor and since 2008 as Full Professor. His group applies genomics, transcriptomics and proteomics technologies for the analysis of cellular adaptation reactions and clinical outcomes, with the following major topics: analysis of stress adaptation reactions and regulatory networks of low-GC Gram-positive bacteria and integration of the complex data in systems biology approaches, characterization of host-pathogen interactions using the Gram-positive pathogen S. aureus as model, utilization of proteomic and transcriptomics technologies for the development of diagnostic and therapeutic signatures, determination of the association of genetic factors with clinical and subclinical phenotypes and analysis of the pathophysiology of cardiovascular diseases using a combination of omics and cell biology approaches.

Talk: Monday, March 09, Session: New Projects in Systems Medicine IV, 4:40 - 4:50 pm

Daniel Weindl

© Weindl

Daniel Weindl studied general biology at the University of Würzburg, Germany. After graduating in 2012, he started his doctoral studies at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg. In 2015 he obtained his PhD degree for the development and application of methods for non-targeted analysis of stable isotope labeling metabolomics data in the context of cancer research. After a short post-doc period at the LCSB, he joined the Institute of Computational Biology (ICB) at the Helmholtz Zentrum Munich in 2016. As postdoctoral fellow, he was developing and applying software tools for efficient simulation and parameter estimation of large dynamical models of signalling networks. Since 2019 he is coordinator/contributor of the BMBF-funded Junior Research Alliance PeriNAA, a joint project with clinical and experimental partners, focusing on the integrative analysis of peripheral N-acetylaspartate (NAA) metabolism. Within PeriNAA, he applies dynamical modelling of cellular metabolism to better understand the role of NAA in health and disease.

Talk: Monday, March 09, Session: New Projects in Systems Medicine IV, 4:50 - 5:00 pm

Dana Westphal

© Westphal

Dr. Dana Westphal obtained her diplom (Master’s equivalent) in biology in 2003 at the Technical University Dresden. She continued her studies at the Otago University in New Zealand and received her PhD in Microbiology in 2008. From 2009-2014, she worked at the Walter and Eliza Hall Institute in Melbourne Australia as a postdoc in molecular biology, researching on the mitochondrial pathway of apoptosis. She currently holds a postdoctoral/junior group leader position at the experimental dermato-oncology lab of the Department of Dermatology, University Hospital Dresden. Her main research focus is on subgroups of melanoma with medical need such as melanoma brain metastases and BRAF wildtype melanoma.

Talk: Monday, March 09, Session: New Projects in Systems Medicine III, 3:35 - 3:45 pm

Helena Zacharias

© Zacharias

Dr. rer. nat. Helena U. Zacharias is heading the junior research group “Computational biomarker discovery” at the Department of Psychiatry and Psychotherapy, University Medicine Greifswald. After finishing her B.Sc. and M.Sc. in physics at the University of Regensburg, she acquired her Ph.D. in biology at the Institute of Functional Genomics, University of Regensburg. She conducted her postdoctoral studies at the chemistry department of the Ohio State University and at the Institute of Computational Biology, Helmholtz Center Munich. Since 2019, she coordinates the e:Med junior research alliance CKDNapp, which develops a clinical decision support software to help the practicing nephrologist in personalized chronic kidney disease patient care. Helena’s research focusses on the improved prediction of adverse events in chronic kidney disease patients, and on obtaining a comprehensive understanding of metabolic pathomechanisms underlying this complex disease.

Talk: Sunday, March 08, Session: New Projects in Systems Medicine I, 5:05 - 5:15 pm

Focus Talks:

Yuanyuan Chen

© Chen

Yuanyuan Chen, PhD for Novogen Europe.

Sponsored Talk for Novogen:
Monday, March 09, Session: Focus Talks, 12:15 - 12:30 pm

Peter Krawitz

© Krawitz

Peter Krawitz studied medicine and physics in Munich, Germany. After theoretical work on Boolean networks at the institute of Systemsbiology in Seattle, he continued with a postdoc at the Max Planck Institute for Molecular Genetics in Berlin. Also in Berlin, he got board certified for Medical Genetics at Charité University medicine. In 2017 he established the Institute for Genomic Statistics and Bioinformatics at University Bonn, where he develops phenotype driven approaches for variant interpretation.

Sponsored Talk for Illumina:
Monday, March 09, Session: Focus Talks, 12:00 - 12:15 pm

Herna Muñoz-Galeano

© Muñoz-Galeano

Herna Muñoz-Galeano is founder and managing director of HMG Systems Engineering (HMG) in Fuerth, Germany. She has over 25 years of international experience in design, development, management of complex engineering systems and innovations. She holds master’s degrees in Electronics Engineering and in Computer Science. In 2016 Herna Muñoz-Galeano has been awarded the “Engineer PowerWoman 2016” by “Hannover Messe” for her accomplishments as an entrepreneur as well as successful electronics and computer science engineer. In 2018 she has been selected for the “EY Entrepreneurial Winning Women™” DACH program and represents Germany in the European program. The IHK Mittelfranken awarded her with the “IHK Gründerpreis 2019” for her outstanding entrepreneurial achievements.

Sponsored Talk for HMG-Systems-Engineering:
Monday, March 09, Session: Focus Talks, 11:45 - 12:00 pm

e:Med Talks:

Maria Fedorova

© Federova

Maria Fedorova studied Biochemistry at Saint-Petersburg State University, Russia and obtained her PhD at Faculty of Chemistry and Mineralogy, Leipzig University, Germany. Now she is a group leader at the Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, at the University of Leipzig. Her research is focused on development and optimization of chromatography and mass spectrometry methods for analysis of lipids and their modified forms. Dr Fedorova group works on implementation of high throughput LC-MS methods in discovery lipidomics targeting in-depth identification and quantification of human lipidome in variety of tissues. By combining lipidomics data with investigation of related proteins and protein post-translational modifications via systems medicine approach, Dr Fedorova aims for a deeper understanding of pathophysiology of obesity, insulin resistance, type II diabetes and cardiovascular disorders.

Talk: Tuesday, March 10, Session: e:Med Project Groups, 9:45 - 10:15 pm

Christoph Schickhardt

© Schickhardt

Dr. phil. Christoph Schickhardt is a philosopher and post-doc researcher in biomedical ethics with a focus on genomics, data sharing and privacy in data driven biomedical research. Christoph is senior scientist at the Translational Medical Ethics Section at the National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ). He was/is leader/coordinator of a number of bioethical research projects focusing on ELSA (ethical, legal and social) aspects of genomics, systems medicine and digitalization in the clinical and research sector. Christoph studied philosophy at the universities of Pavia, Italy, and Lausanne, Switzerland, and was awarded a PhD degree in Philosophy (Ethics) with a thesis on Child Ethics by the University of Düsseldorf, Germany, in 2011. Christoph teaches ethics and philosophy at the University of Heidelberg.

Talk: Tuesday, March 10, Session: e:Med Project Groups, 9:45 - 10:15 pm