Program

as at 2017-11-17

Tuesday, November 21, 2017

Tue Nov 21 Topic Speaker

10:00 - 11:00 am

Breakout project group

Informatics & Modelling

Chair PG 1: Matthias Ganzinger

11:00-01:00 pm

Satellite Symposium:

Technological Innovations

Organized by

PG Epigenetics & Sequencing.

Chairs:

Friedrich Feuerhake

Karsten Rippe

Philip Rosenstiel

11:00 - 11:30 am

Unraveling the tumor microenvironment architecture by multispectral imaging

Angela Vasaturo, INSERM, Paris

(sponsored by Perkin Elmer)

11:30 - 12:00 pm

Follow response to treatment by single-cell sequencing

Philipp Mallm, DKFZ Heidelberg

(sponsored by 10x Genomics)

12:00 - 12:30 pm

Unravelling cellular heterogeneity - a single cell biology approach

Andreas Schlitzer,

University of Bonn

12:30 - 01:00 pm

High resolution single cell analysis in complex adult tissues

Stefan Günther, MPI Bad Nauheim

(sponsored by WaferGen)

01:00 - 01:45 pm

Registration & welcome supper

01:45 - 02:00 pm

Welcome speech

Tanja Zeller, Speaker e:Med PK

Blanche Schwappach,

UMG/Uni Göttingen

Johannes Mohr, BMBF

02:00 - 02:45 pm

Visionary Talk:

Design principles of circuits for tissue homeostasis

Uri Alon,

Weizmann Institute, Israel

02:45 - 04:00 pm

Session 1:

Technologies in systems medicine

Chairs: Philip Rosenstiel,

Frank Kramer

02:45 - 03:15 pm

Keynote lecture: LEAN analysis biological network hot spots in the age of Big Data

Benno Schwikowski

Institut Pasteur, Paris

03:15 - 03:30 pm

Metabolomic changes in lymphoma in response to stromal stimuli

Wolfram Gronwald

University of Regensburg

03:30 - 03:45 pm

Spatial organization of B cells and T cells predicts loss of renal transplant function

Katharina Nekolla

Definiens AG, Munich

03:45 - 04:00 pm

Introducing the de.NBI Cloud – the novel compute and storage infrastructure for life sciences

Chris Lawerenz

DKFZ Heidelberg

04:00 - 04:30 pm

Coffee break

04:30 - 06:30 pm

Poster session 1

04:30 - 05:00 pm

Poster flash talks

(11 talks à 3 min)

Chair: Ingo Röder

05:00 - 06:30 pm

Poster exhibition

06:30 - 07:30 pm

Public event:

Karriere in der Systemmedizin

Roberto Goya-Maldonado

Frank Kramer

Antje Walz

Markus Nöthen

Uri Alon

07:45 - 10:00 pm

Get together with wine & snacks

networking at the venue

Wednesday, November 22, 2017

Wed Nov 22 Topic Speaker

08:30 - 09:00 am

Welcome coffee

09:00 - 10:30 am

Session 2:

Systems Medicine in the European context

Chair: Peter Lichter,

Karsten Rippe

09:00 - 09:30 am

SYSCID – A Systems medicine approach to chronic inflammatory diseases

Philip Rosenstiel

Kiel University

09:30 - 10:00 am

German imaging science in European context

Bernd Pichler

University Hospital Tübingen

10:00 - 10:30 am

Medical Informatics Initiative and Systems Medicine Initiative – An opportunity not to miss –

Markus Löffler

University of Leipzig

10:30 - 11:00 am

Coffee break

11:00 - 12:30 pm

Session 3:

Systems medicine of diseases

Chair: Roberto Goya-Maldonado,

Dagmar Kulms

11:00 - 11:30 am

Keynote lecture: Frontostriatal mechanisms of anhedonia in novel neurophysiological subtypes of depression

Conor Liston,

Weill Cornell Medicine,

New York

11:30 - 11:45 am

Metabolomics in Translational Medicine – A Link between Acylcarnitines and Atrial Fibrillation

Julia Krause

University Medical Center

Hamburg-Eppendorf, DZHK

11:45 - 12:00 pm

Reconstruction of tumor evolution from massively parallel sequencing data

Nima Abedpour

University of Cologne

12:00 - 12:15 pm

Transcriptomic landscape of Pancreatic Cancer and normal Epithelial and Stromal cells directly isolated from human samples reveals common and cell-type specific deregulated nodes

Elisa Espinet

HI-STEM & DKFZ Heidelberg

12:15 - 12:30 pm

Multi-omics analysis methods for the genetic diagnosis of rare diseases

Vicente Yépez

Technical University of Munich

12:30 - 02:30 pm

Lunch break

01:00 - 01:30 pm

Company session:

Olink: A precision proteomics solution for targeted human protein biomarker discovery

Martin Lundberg, Olink Proteomics

01:40 - 02:10 pm

Company Session: HMG Systems Engineering

Clinical Implementation of Pharmacogenetics

Ingolf Cascorbi, UKSH

for HMG Systems Engineering

02:30 - 04:00 pm

Session 4:

Modelling in systems medicine

Chairs:Friedrich Feuerhake,

Markus Löffler

02:30 - 03:00 pm

Keynote lecture

From Ideas to Medicine – with Modelling and Simulation

Antje Walz,

Quantitative systems

pharmacology Roche, Basel

03:00 - 03:15 pm

Predicting sensitivity of malignant melanoma to combination therapies by network modeling

Dagmar Kulms

TU Dresden

03:15 - 03:30 pm

A drug - cytokine interaction map for lympho-proliferative disorders

Peter-Martin Bruch

University Hospital Heidelberg

03:30 - 03:45 pm

Computational modelling of amino acid signaling to kinase networks

Kathrin Thedieck

University Medical Center

Groningen & University Oldenburg

03:45 - 04:00 pm

Clonal evolution in adult glioblastoma

Verena Körber

DKFZ Heidelberg

04:00 - 04:15 pm

Coffee break

04:15 - 05:00 pm

Der neue EU-Datenschutz: Folgen für die Forschung

Boris Reibach,

University of Oldenburg

PG Data Security & Ethics

05:00 - 07:00 pm

Poster session 2

Even numbers

05:00 - 05:30 pm

Poster flash talks

(10 talks à 3 min)

Chair: Tanja Zeller

05:30 - 07:00 pm

Poster discussion

06:45 - 07:30 pm

Breakout Project Groups

PG 3: Image Processing

PG 4: Data security & Ethics

Chair PG 3: Bernd Pichler

Chair PG 4:

Christoph Schickhardt

07:30 - open end

e:Med dinner & party

Restaurant Bullerjahn

Music by Maewan Forest

Thursday, November 23, 2017

Wed Nov 23 Topic Speaker

08:30 - 09:00 am

Welcome coffee

09:00 - 10:30 am

Session 5:

Systems medicine impulse talks

Chair: Ingo Röder, Michael Ziller

09:00 - 09:30 am

Closing the translational gap – integration of high-throughput data for personalized cancer treatments into clinical processes

Oliver Kohlbacher,

University of Tuebingen

iD:Sem

09:30 - 10:00 am

Progressive fibrosis as driving force behind liver cirrhosis, liver failure and hepatocellular carcinoma

Peter Jansen

AMC Amsterdam

LiSyM

10:00 - 10:30 am

The de.NBI network – a Bioinformatics Infrastructure in Germany for Handling Big Data in Life Sciences

Alfred Pühler,

University of Bielefeld

de.NBI

10:30 - 11:00 am

Coffee break

11:00 - 12:30 pm

Session 6:

Systems medicine approaches in clinics 1

Chair: Markus Nöthen, nn

11:00 - 11:30 am

Keynote lecture

Erwin Böttinger,

Hasso-Plattner Institute &

University of Potsdam

11:30 - 11:45 am

Updates on the ENIGMA-Epigenetics Working Group

Sylvane Desrivières

King’s College London,

United Kingdom

11:45 - 12:00 pm

Integrating multi-omics and multi-modality medical imaging to assess hepatocellular carcinoma patient outcome under Sorafenib treatment: A progress report of the Multiscale HCC project

Mathew Divine

University of Tübingen

12:00 - 12:15 pm

Multi-omics based strategy to predict graft function and personalize immunosuppressive therapy in kidney transplantation

Nina Babel

Charité Berlin

12:15 - 02:15 pm

Lunch break

12:45 - 01:15 pm

Company session: illumina

Experiences from the 2017 e:Med Summer School

How advancements in Next Generation Sequencing support Functional Genomics Research

Karsten Rippe, DKFZ

Matthias Prucha, Illumina

01:30 - 02:00 pm

Company session: Lexogen

Gene Expression Profiling of Blood Samples: QuantSeq 3’ mRNA-Seq Library Preparation with Globin Reduction

Lukas Paul,

Lexogen GmbH

02:15 - 03:30 pm

Session 6:

Systems medicine approaches in clinics 2

Chairs: Tanja Zeller, Nina Babel

02:15 - 02:45 pm

Pharmacogenomics: from translational research to next generation benefit-risk evaluation

Julia Stingl,

Federal Institute for Drugs

and Medical Devices

02:45 - 03:00 pm

Anti-TNFα restores disrupted metabolic interaction of the intestinal microbiome in IBD

Ateequr Rehman

Christian-Albrechts-

University, Kiel

03:00 - 03:15 pm

“Systems hematology” – Opportunities, benefits, and limitations

Ingo Roeder

TU Dresden

03:15 - 03:30 pm

How to report somatic variants in molecular tumor boards

Tim Beissbarth

University Medical Center

Göttingen

03:30 - 03:45 pm

Poster award ceremony

Closing remarks

03:45 - 04:30 pm

Coffee & snacks

04:15 - 05:15 pm

Meeting e:Med Project Committee (by invitation)

 

Poster FlashTalks:

Poster FlashTalks I - Tuesday, Nov 21, 4:30 - 5:00 pm

# Topic Speaker

1

Spatial Gene Expression in Liver – Regulation by Autocrine and Paracrine Wnt/β-Catenin Signalling

Uwe Benary,

MDC Berlin

2

Long-Term Conservation of Bioinformatics Pipelines for Systems Medicine

Matthias Ganzinger,

Heidelberg University

3

ndexr – an R package to interface with the Network Data Exchange

Florian Auer,

University Medical Center

Göttingen

4

Comparing characteristic genomic variants allows reliable in-silico identification of Next-Generation sequenced Cancer Cell Line samples

Raik Otto

HU & Charité Berlin

5

Implementing a multilayer framework for pathway data integration, analysis and visualization

Zaynab Hammoud

University Medical Center

Göttingen

6

A hierarchical stochastic model for bistable perception

Stefan Albert,

Goethe-University

Frankfurt

7

Establishment of Multi-OMICs Pathway Analysis in Human Atrial Fibrillation

Ines Assum,

Helmholtz Zentrum

Munich

8

Oxytocin reduces alcohol cue-reactivity in alcohol dependent rats and humans

Anita Hansson,

ZI Mannheim

9

Central validation of HER2 status to determine heterogeneity of marker expression in HER2 positive gastric cancer (GC)

Ivonne Haffner,

University Hospital Leipzig

10

Longitudinal analysis of cytokine profiles in community-acquired pneumonia

Maciej Rosolowski,

University Leipzig

11

Cytokine X* is a component of a pathway leading to allograft damage and an early indicator of poor graft function in patients after kidney transplantation (* Patent application in preparation)

Ellen Witte,

Charité Berlin

Poster FlashTalks I - Wednesday, Nov 22, 5:00 - 5:30 pm

# Topic Speaker

1

Multiscale analysis by acquisition of image and molecular fingerprints for patients under systemic treatment of hepatocellular carcinoma

Michael Bitzer

University of Tuebingen

2

Harnessing the predictive potential of tumor heterogeneity via the integration of MALDI imaging data and dynamic modeling

Haralampos Hatzikirou

Helmholtz Centre for

Infection Research Braunschweig

3

Pre-mapping Networks for Brain Stimulation (PreNeSt)

Tracy Erwin-Grabner

University Medical Center

Göttingen

4

BKV clearance time correlates with the exhaustion state and T-cell receptor repertoire shape of BKV-specific T-cells in renal transplant patients with severe BKV infection

Ulrik Stervbo

University Hospital

Ruhr University &

Charité Berlin

5

Exome sequencing of multiply affected bipolar disorder families and follow-up resequencing implicate rare variants in neuronal genes contributing to disease etiology

Anna Maaser

University of Bonn

6

Metformin reverses TRAP1 mutation- associated alterations in mitochondrial function in Parkinson’s disease

Julia Fitzgerald

Hertie Institute

University of Tuebingen

7

Inflammatory bowel disease progression is associated to epigenetic regulators and their target genes

Robert Häsler

Christian-Albrechts-

University, Kiel

8

Genetic determinants of aberrant splicing events in coronary artery disease

Baiba Vilne

TU Munich

9

Using Mixed Integer Linear Programming to identify regulators of telomerase expression

Alexandra Poos,

Jena University Hospital,

Hans Knöll Institute Jena,

DKFZ

10

Common genetic variants associated with personality dimensions in the Heidelberg Cohort Study of the Elderly (HeiDE): an update

Urs Heilbronner,

University Hospital,

LMU Munich