Preliminary Digital Program

The program is spread over three days with many starting points for lively interaction.

Preliminary program as at 2021-09-17:

Monday, September 20, 2021

Mon Sep 20 Topic Speaker

01:00 - 01:15 pm

Welcome Address

BMBF

Spokesperson

e:Med Project Committee

01:15 - 02:45 pm

Technologies in Systems Medicine

01:15 - 01:45 pm

Keynote: Systems Medicine of

Chronic Inflammatory Diseases

– from cellular trajectories

Philip Rosenstiel

Universitätsklinikum

Schleswig-Holstein, Kiel

01:45 - 02:00 pm

Single-cell proteo-

genomic reference maps of the

hematopoietic system enable the

purification and massive profiling

of precisely defined cell states

Dominik Vonficht

DKFZ,

Heidelberg

02:00 - 02:15 pm

Translating the Spatial Inflammatory

Microenvironment in Digital Biopsy

Nadine Sarah Schaadt,

Institute for Pathology,

Hannover Medical School

02:15 - 02:30 pm

Personalized Treatment

of Anemia Associated to Chronic

Kidney Disease

Agustin Rodriguez,

DKFZ, Heidelberg

02:30 - 02:45 pm

Panel discussion

02:45 - 03:00 pm

Coffee Break

Networking Tables

03:00 - 04:15 pm

Bioinformatic Approaches and

Machine Learning in Systems

Medicine

03:00 - 03:15 pm

Predicting correlated outcomes

from molecular data

Armin Rauschenberger,

University of Luxembourg

03:15 - 03:30 pm

Enrichment of Alternative

Splicing Events Identifies Biomarkers

for Multiple Sclerosis and Dilated

Cardiomyopathy

Zakaria Louadi,

Technical University Munich

and University of Hamburg

03:30 - 03:45 pm

ENIGMA MDD: Basic benchmark classification of MDD and HC using FreeSurfer’s output of structural MRI information

Vladimir Belov,

UMG Göttingen

03:45 - 04:00 pm

Genetic regulation of

cytokine response in patients with

acute community-acquired

pneumonia

Andreas Kühnapfel,

University Leipzig

04:00 - 04:15 pm

Panel discussion

04:15 - 04:30 pm

virtual Break

Networking Tables

04:30 - 05:15 pm

Networking Fonds Alliances

04:30 - 04:40 pm

INCOME - Integrative, collaborative modelling in systems medizin

Jan Hasenauer,

University Bonn

04:40 - 04:50 pm

MultiCellML - Networking through exchange of multicellular computational models

Lutz Brusch

TU Dresden

04:50 - 05:00 pm

AbCD-Net - Aberrant transcriptome influencing risk of common diseases

Julien Gagneur

TU Munich

05:15 - 15:45 pm

Open-ended Networking

Interact and meet

with your peers

Tuesday, September 21, 2021

Tue 21, Sept Topic Speakers

11:00 - 12:15 pm

Poster Session A

11:00 - 11:30 am

Poster Flash Talks A

10 talks à 2 min

11:30 - 12:15 pm

Poster Exhibition

12:15 - 01:00 pm

Lunch with Sponsor

Sham Naal

Illumina

01:00 - 02:30 pm

Multi Omics in Systems Medicine

01:00 - 01:30 pm

Keynote

Integrating genetics in the assessment

for coronary disease

Heribert Schunkert,

Deutsches Herzzentrum,

München

01:30 - 01:45 pm

Longitudinal multi-omics

analysis identifies early blood-based

predictors of anti-TNF therapy

response in inflammatory bowel

disease

Neha Mishra,

University Hospital

Schleswig-Holstein,

Campus Kiel

01:45 - 02:00 pm

A senescence-focused multi-omics

approach unravels complexities

of treatment resistance in B-cell

lymphomas

Paulina Richter-Pechanska,

Charité Berlin

02:00 - 02:15 pm

Tissue-specific multi-omics

analysis of atrial fibrillation

Matthias Heinig,

Helmholtz Zentrum

München

02:15 - 02:30 pm

Panel Discussion

02:30 - 02:45 pm

Break

02:45 - 3:45 pm

Modelling in Systems Medicine

2:45 - 03:00 pm

Simulating and parameterizating

computational models

of multi-cellular processes

Emad Alamoudi,

University of Bonn

03:00 - 03:15 pm

In silico-guided optimisation of

a CNS-targeted TNFR2-agonist

for treatment of

neurodegenerative diseases

Gavin Fullstone,

University of Stuttgart

03:15 - 03:30 pm

A systematic approach to

decipher crosstalk in the p53 signaling

pathway using single cell dynamics

Fabian Konrath,

Max-Delbrueck-Center,

Berlin

03:30 - 03:45 pm

Panel Discussion

03:45 - 04:00 pm

Break

04:00 - 04:45 pm

Systems Medicine of COVID-19

04:00 - 04:15 pm

Chronic ethanol intake

influences gene expression of

SARS-CoV2 infection relevant genes in

an organ-specific manner

Marion M. Friske,

CIMH Mannheim

04:15 - 04:30 pm

Systematic Analysis of

Alternative Splicing in Time Course Data

of SARS-Cov2 infection development

using Spycone

Chit Tong Lio,

Technical University,

Munich

04:30 - 04:45 pm

Panel Discussion

04:45 - 05:00 pm

Break

05:00 - 05:15 pm

PG Impulse

05:15 - 05:45 pm

PG Parallel Meetings

05:45 pm

Open-ended Networking

Wednesday, September 22, 2021

Wed Sept 22 Topic Speaker

11:00 - 12:15 pm

Poster Session B

11:00 - 11:30 am

Poster Flash Talks B

10 talks à 2 min

11:30 - 12:15 pm

Poster Exhibition

12:15 - 1:00 pm

Lunch with Sponsors

Peter Krawitz

Life & Brain

1:00 - 2:15 pm

Systems Medicine of Tumor Heterogeneity

01:00 - 01:30 pm

Keynote

Molecular Landscape of Lung Tumors

Julie George,

University of Cologne

01:30 -01:45 pm

Patient-specific modeling

of diffuse-large B cell lymphoma

allows individualised target predictions

Jana Wolf,

MDC, Berlin

01:45 - 02:00 pm

Mapping changes in Triple

Negative Breast Cancer in response

to neoadjuvant chemotherapy at

protein, transcriptome and

genomic level

Dražen Papić,

Charité, Berlin

02:00 - 02:15 pm

Panel Discussion

02:15 - 02:30 pm

Break

02:30 - 03:30 pm

Translational Systems Medicine

02:30 - 02:45 pm

A novel senolytic compound

preventing Ras-driven tumorigenesis

Maurice Reimann,

Charité, Berlin

02:45 - 03:00 pm

In vivo validation of

therapeutic targets that inhibit

melanoma brain metastatic growth

Matthia A. Karreman,

DKFZ, NCT,

University Hospital,

Heidelberg

03:00 - 03:15 pm

Multi-omics analysis

identifies JAK-STAT pathway as

crucial regulator tryptophan

metabolism in IBD

Konrad Aden,

UKSH Kiel

03:15 - 03:30 pm

Panel Discussion

03:30 - 03:45 pm

Break

03:45 - 04:30 pm

Symposium Future of Systems Medicine

04:30 - 04:45 pm

Break

04:45 - 05:00 pm

Closing Remarks & Poster Award Ceremony

05:00 pm

Open-ended Networking

 

Poster Flash Talks:

Poster Flash Talks A: Tuesday, September 21, 11:00 - 11:30 AM

# Topic Speaker

1

Comprehensive Evaluation of Alternative Splicing Analysis Tools

Amit Fenn,

TUM

2

The German Human Genome-Phenome

Archive (GHGA) – A national infrastructure

for secure archival and community-driven

analysis of omics data

Ulrike Träger,

DKFZ Heidelberg

3

Automated annotation of rare-cell types from single-cell1RNA-sequencing data through synthetic oversampling

Saptarshi Bej,

Technical University of Munich

4

dsMTL - a computational framework for privacy-

preserving, distributed multi-task machine

learning

Han Cao,

ZI Mannheim

5

Selecting defined tumor antigens

for peptide-based treatments in

uveal melanoma with machine

learning

Martin Eberhardt,

Universitätsklinikum Erlangen

und FAU Erlangen-Nürnberg

6

Interlinking pathway and network

analysis in systems biomedicine

Enrico Glaab,

University of Luxembourg

7

Chromatin-accessibility estimation from single-cell ATAC data with scOpen

Zhijian Li

RWTH Aachen University

Erasmus Medical Center, Rotterdam

8

Effect of NAT8L overexpression on

cancer cell metabolism

Tobias Ludwig,

TU Braunschweig

9

DNA methylation-based assessment

of smoking status in the brain

Lea Zillich,

ZI Mannheim

10

Association between clinical data and microbiome samples in AD patients

Jan Hartmann,

University Hospital

Kiel

Poster Flash Talks B: Wednesday, September 22, 11:00 - 11:30 AM

# Topic Speaker

20

Gene and pathway signatures of

cancer immunotherapy related

autoimmunity elucidated by gene

expression profiling, network analysis

and computational modeling

Julio Vera,

FAU Erlangen-Nürnberg

12

Integration of transcriptomics data into hybrid,

agent-based models of cancer and autoimmunity

Jimmy Retzlaff,

Universitätsklinikum

Erlangen

13

NaviCenta - Navigate Data in a Placenta Specific Disease Map

Julia Scheel,

Universität Rostock

14

A biomathematical model of

atherosclerosis in mice

Sibylle Schirm,

IMISE,

University of Leipzig

15

Understanding crosstalk between tumor

and autoimmune diseases using disease

map approaches

Krishna P Singh

University of Rostock

16

SysMEDSUDs - Comparative Measures

of Cocaine and Nicotine Self-Administration:

The Role of Ras-ERK

Rick E. Bernardi,

ZI, Mannheim

17

Reprogramming the melanoma-immune

cell interface by tumor-intrinsic E2F1

and its implications for autoimmunity

upon cancer immunotherapy

Stella Logotheti,

University Medical Center,

Rostock

18

Towards Targeted Oxytocin Treatment

in Alcohol Addiction

Marcus Meinhardt,

ZI-Mannheim

19

Working memory correlates with

clinical improvement in patients

with major depressive disorder

undergoing intermittent theta

burst stimulation treatment

Asude Tura,

University Medical Center Göttingen

11

A user-friendly software framework

for multi-scale and multicellular modeling

in systems medicine

Robert Müller,

TU Dresden

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