Omics analyses and longitudinal gene expression analysis
Within this subproject we will investigate the association between atrial fibrillation and the genotype data and gene expression data. Prior to the analysis the genotype data will be imputed against the latest reference panel to fill in missing genotype data and gain information about more markers through haplotype estimation. This is followed by an association analysis between atrial fibrillation related phenotypes and the genotype data.
For the gene expression data some extended preprocessing is necessary. Measurements for two time points are available and in order to analyse them jointly, differences caused by technical variation need to be removed. This harmonisation and the subsequent statistical analysis are part of this subproject.