CKDNapp

Altenbuchinger, M., H. Berndt, R. Kosch, I. Lang, J. Dönitz, P. J. Oefner, W. Gronwald, H. U. Zacharias and I. G. Study (2022). "Bucket Fuser: Statistical Signal Extraction for 1D 1H NMR Metabolomic Data." Metabolites 12(9): 812. CKDNapp doi.org/10.3390/metabo12090812.

Bächle, H., P. Sekula, P. Schlosser, I. Steinbrenner, Y. Cheng, F. Kotsis, H. Meiselbach, H. Stockmann, S. Schönherr, G. investigators, K.-U. Eckardt, O. Devuyst, J. Scherberich, A. Köttgen and U. T. Schultheiss (2022). "Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study." Nephrology Dialysis Transplantation. CKDNapp doi.org/10.1093/ndt/gfac187.

Ben Guebila, M., D. Weighill, C. M. Lopes-Ramos, R. Burkholz, R. T. Pop, K. Palepu, M. Shapoval, M. Fagny, D. Schlauch, K. Glass, M. Altenbuchinger, M. L. Kuijjer, J. Platig and J. Quackenbush (2022). "An online notebook resource for reproducible inference, analysis and publication of gene regulatory networks." Nature Methods 19(5): 511-513. CKDNapp doi.org/10.1038/s41592-022-01479-2.

Cheng, Y., Y. Li, N. Scherer, F. Grundner-Culemann, T. Lehtimäki, B. H. Mishra, O. T. Raitakari, M. Nauck, K.-U. Eckardt, P. Sekula, U. T. Schultheiss and G. i. on behalf of the (2022). "Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study." PLOS Genetics 18(4): e1010139. CKDNapp doi.org/10.1371/journal.pgen.1010139.

Kheirkhah, A., C. Lamina, B. Kollerits, J. F. Schachtl-Riess, U. T. Schultheiss, L. Forer, P. Sekula, F. Kotsis, K.-U. Eckardt and F. Kronenberg (2022). "PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function." CJASN 17(6): 809–818. CKDNapp doi.org/10.2215/CJN.01230122.

Li, Y., Y. Cheng, F. Consolato, G. Schiano, M. R. Chong, M. Pietzner, N. Q. H. Nguyen, N. Scherer, M. L. Biggs, M. E. Kleber, S. Haug, B. Göçmen, M. Pigeyre, P. Sekula, I. Steinbrenner, P. Schlosser, C. B. Joseph, J. A. Brody, M. E. Grams, C. Hayward, U. T. Schultheiss, B. K. Krämer, F. Kronenberg, A. Peters, J. Seissler, D. Steubl, C. Then, M. Wuttke, W. März, K.-U. Eckardt, C. Gieger, E. Boerwinkle, B. M. Psaty, J. Coresh, P. J. Oefner, G. Pare, C. Langenberg, J. E. Scherberich, B. Yu, S. Akilesh, O. Devuyst, L. Rampoldi and A. Köttgen (2022). "Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases." JCI Insight 7(10). CKDNapp doi.org/10.1172/jci.insight.157035.

Lück, N., R. Lohmayer, S. Solbrig, S. Schrod, T. Wipfler, K. H. Shutta, M. B. Guebila, A. Schäfer, T. Beißbarth, H. U. Zacharias, P. J. Oefner, J. Quackenbush and M. Altenbuchinger (2022). "SpaCeNet: Spatial Cellular Networks from omics data." bioRxiv: 2022.2009.2001.506219. CKDNapp doi.org/10.1101/2022.09.01.506219.

Mielke, J., H. Trucks-Jansen, C. Schurmann, F. Kotsis, A. Kottgen, M. P. Schneider, K. U. Eckardt, G. Investigators, D. F. Freitag, F. Eitner and M. S. Becker (2022). "Prevalence, phenotypic characteristics and prognostic role of apparent treatment resistant hypertension in the German Chronic Kidney Disease (GCKD) study." J Hum Hypertens. CKDNapp www.ncbi.nlm.nih.gov/pubmed/35534618.

Schrod, S., A. Schäfer, S. Solbrig, R. Lohmayer, W. Gronwald, P. J. Oefner, T. Beißbarth, R. Spang, H. U. Zacharias and M. Altenbuchinger (2022). "BITES: balanced individual treatment effect for survival data." Bioinformatics 38(Supplement_1): i60–i67. CKDNapp doi.org/10.1093/bioinformatics/btac221.

Schultheiss, U. T., H. Bächle, M. Altenbuchinger, H. Meiselbach, R. Kosch, S. Salloch, T. Bratan, H. U. Zacharias and F. Kotsis (2022). MO474: Expectation and Acceptance of a Clinical Decision Support Software by Nephrologist End-Users: The Ckdnapp Survey. 59th ERA Congress. Paris & Virtual, Nephrol Dial Transplant. 37.

Shutta, K. H., D. Weighill, R. Burkholz, M. B. Guebila, D. L. DeMeo, H. U. Zacharias, J. Quackenbush and M. Altenbuchinger (2022). "DRAGON: Determining Regulatory Associations using Graphical models on multi-Omic Networks." Nucleic Acids Res. CKDNapp doi.org/10.1093/nar/gkac1157.

Steinbrenner, I., P. Sekula, F. Kotsis, M. von Cube, Y. Cheng, J. Nadal, M. Schmid, M. P. Schneider, V. Krane, M. Nauck, K.-U. Eckardt, U. T. Schultheiss and t. G. investigators (2022). "Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study." Nephrology Dialysis Transplantation. CKDNapp doi.org/10.1093/ndt/gfac173.

Surendran, P., I. D. Stewart, V. P. W. Au Yeung, M. Pietzner, J. Raffler, M. A. Wörheide, C. Li, R. F. Smith, L. B. L. Wittemans, L. Bomba, C. Menni, J. Zierer, N. Rossi, P. A. Sheridan, N. A. Watkins, M. Mangino, P. G. Hysi, E. Di Angelantonio, M. Falchi, T. D. Spector, N. Soranzo, G. A. Michelotti, W. Arlt, L. A. Lotta, S. Denaxas, H. Hemingway, E. R. Gamazon, J. M. M. Howson, A. M. Wood, J. Danesh, N. J. Wareham, G. Kastenmüller, E. B. Fauman, K. Suhre, A. S. Butterworth and C. Langenberg (2022). "Rare and common genetic determinants of metabolic individuality and their effects on human health." Nat Med: 1–12. CKDNapp doi.org/10.1038/s41591-022-02046-0.

Winitzki, D., H. U. Zacharias, J. Nadal, S. Baid-Agrawal, E. Schaeffner, M. Schmid, M. Busch, M. M. Bergmann, U. Schultheiss, F. Kotsis, H. Stockmann, H. Meiselbach, G. Wolf, V. Krane, C. Sommerer, K.-U. Eckardt, M. P. Schneider, G. Schlieper, J. Floege and T. Saritas (2022). "Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort." Kidney International Reports 7(5): 1004–1015. CKDNapp doi.org/10.1016/j.ekir.2022.02.001.

Zacharias, H. U., M. Altenbuchinger, U. T. Schultheiss, J. Raffler, F. Kotsis, S. Ghasemi, I. Ali, B. Kollerits, M. Metzger, I. Steinbrenner, P. Sekula, Z. A. Massy, C. Combe, P. A. Kalra, F. Kronenberg, B. Stengel, K. U. Eckardt, A. Kottgen, M. Schmid, W. Gronwald, P. J. Oefner and G. Investigators (2022). "A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests." Am J Kidney Dis 79(2): 217-230 e211. CKDNapp www.ncbi.nlm.nih.gov/pubmed/34298143.

Zacharias, H. U., C. Kaleta, F. Cossais, E. Schaeffer, H. Berndt, L. Best, T. Dost, S. Glüsing, M. Groussin, M. Poyet, S. Heinzel, C. Bang, L. Siebert, T. Demetrowitsch, F. Leypoldt, R. Adelung, T. Bartsch, A. Bosy-Westphal, K. Schwarz and D. Berg (2022). "Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Targets." Metabolites 12(12): 1222. CKDNapp doi.org/10.3390/metabo12121222.

Kotsis, F., U. T. Schultheiss, M. Wuttke, P. Schlosser, J. Mielke, M. S. Becker, P. J. Oefner, E. D. Karoly, R. P. Mohney, K. U. Eckardt, P. Sekula, A. Kottgen and G. Investigators (2021). "Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study." J Am Soc Nephrol 32(9): 2315-2329. CKDNapp www.ncbi.nlm.nih.gov/pubmed/34140400.

Lotta, L. A., M. Pietzner, I. D. Stewart, L. B. L. Wittemans, C. Li, R. Bonelli, J. Raffler, E. K. Biggs, C. Oliver-Williams, V. P. W. Auyeung, J. a. Luan, E. Wheeler, E. Paige, P. Surendran, G. A. Michelotti, R. A. Scott, S. Burgess, V. Zuber, E. Sanderson, A. Koulman, F. Imamura, N. G. Forouhi, K.-T. Khaw, M. Bahlo, J. L. Griffin, A. M. Wood, G. Kastenmüller, J. Danesh, A. S. Butterworth, F. M. Gribble, F. Reimann, M. Bahlo, E. Fauman, N. J. Wareham, C. Langenberg and M. Consortium (2021). "A cross-platform approach identifies genetic regulators of human metabolism and health." Nat Genet 53(1): 54–64. CKDNapp doi.org/10.1038/s41588-020-00751-5.

Pammer, L. M., C. Lamina, U. T. Schultheiss, F. Kotsis, B. Kollerits, H. Stockmann, J. Lipovsek, H. Meiselbach, M. Busch, K.-U. Eckardt and F. Kronenberg (2021). "Association of the metabolic syndrome with mortality and major adverse cardiac events: A large chronic kidney disease cohort." J Intern Med 290(6): 1219–1232. CKDNapp doi.org/10.1111/joim.13355.

Pietzner, M., I. D. Stewart, J. Raffler, K.-T. Khaw, G. A. Michelotti, G. Kastenmüller, N. J. Wareham and C. Langenberg (2021). "Plasma metabolites to profile pathways in noncommunicable disease multimorbidity." Nat. Med. 27(3): 471–479. CKDNapp doi.org/10.1038/s41591-021-01266-0.

Schultheiss, U. T., R. Kosch, F. Kotsis, M. Altenbuchinger and H. U. Zacharias (2021). "Chronic Kidney Disease Cohort Studies: A Guide to Metabolome Analyses." Metabolites 11(7). CKDNapp doi.org/10.3390/metabo11070460.

Schultheiss, U. T. and P. Sekula (2021). "The Promise of Metabolomics in Decelerating CKD Progression in Children." CJASN 16(8): 1152–1154. CKDNapp doi.org/10.2215/CJN.07400521.

Schultheiss, U. T., I. Steinbrenner, M. Nauck, M. P. Schneider, F. Kotsis, S. Baid-Agrawal, E. Schaeffner, K.-U. Eckardt, A. Köttgen, P. Sekula, K.-U. Eckardt, H. Meiselbach, M. P. Schneider, M. Schiffer, H.-U. Prokosch, B. Bärthlein, A. Beck, D. Kraska, A. Reis, A. B. Ekici, S. Becker, D. Becker-Grosspitsch, U. Alberth-Schmidt, B. Hausknecht, A. Weigel, G. Walz, A. Köttgen, U. T. Schultheiß, F. Kotsis, S. Meder, G. Schlieper, E. Schaeffner, S. Baid-Agrawal, K. Theisen, H. Haller, J. Menne, M. Zeier, C. Sommerer, R. Woitke, G. Wolf, M. Busch, R. Paul, T. Sitter, C. Wanner, V. Krane, A. Börner-Klein, B. Bauer, J. Raschenberger, B. Kollerits, L. Forer, S. Schönherr, H. Weissensteiner, P. Oefner, W. Gronwald, M. Schmid and J. Nadal (2021). "Thyroid function, renal events and mortality in chronic kidney disease patients: the German Chronic Kidney Disease study." Clin Kidney J 14(3): 959-968. CKDNapp doi.org/10.1093/ckj/sfaa052.

Steinbrenner, I., U. T. Schultheiss, F. Kotsis, P. Schlosser, H. Stockmann, R. P. Mohney, M. Schmid, P. J. Oefner, K. U. Eckardt, A. Kottgen, P. Sekula and I. German Chronic Kidney Disease (2021). "Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study." Am J Kidney Dis 78(5): 669-677 e661. CKDNapp www.ncbi.nlm.nih.gov/pubmed/33839201.

Zacharias, H. U., J. Hertel, H. Johar, M. Pietzner, K. Lukaschek, S. Atasoy, S. Kunze, H. Volzke, M. Nauck, N. Friedrich, G. Kastenmuller, H. J. Grabe, C. Gieger, J. Krumsiek and K. H. Ladwig (2021). "A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression." Mol Psychiatry 26(12): 7372-7383. CKDNapp doi.org/10.1038/s41380-021-01176-0.

Bonk, S., J. Hertel, H. U. Zacharias, J. Terock, D. Janowitz, G. Homuth, M. Nauck, H. Völzke, H. Meyer zu Schwabedissen, S. Van der Auwera and H. J. Grabe (2020). "Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders." Sci Rep 10(22394): 1–9. IntegraMent & CKDNapp doi.org/10.1038/s41598-020-79388-7.

Fazzini, F., C. Lamina, J. Raschenberger, U. T. Schultheiss, F. Kotsis, S. Schönherr, H. Weissensteiner, L. Forer, I. Steinbrenner, H. Meiselbach, B. Bärthlein, C. Wanner, K.-U. Eckardt, A. Köttgen, F. Kronenberg and G. Investigators (2020). "Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease." Kidney International. CKDNapp doi.org/10.1016/j.kint.2020.02.034.

Pietzner, M., E. Wheeler, J. Carrasco-Zanini, J. Raffler, N. Kerrison, E. Oerton, V. Au Yeung, J. Luan, C. Finan, J. Casas, R. Ostroff, S. Williams, G. Kastenmüller, M. Ralser, E. Gamazon, N. Wareham, A. Hingorani and C. Langenberg (2020). "Genetic architecture of host proteins involved in SARS-CoV-2 infection." Nature Communications. CKDNapp doi.org/10.17863/CAM.59991.

Sekula, P., A. Tin, U. T. Schultheiss, S. Baid-Agrawal, R. P. Mohney, I. Steinbrenner, B. Yu, S. Luo, E. Boerwinkle, K.-U. Eckardt, J. Coresh, M. E. Grams and A. Kӧttgen (2020). "Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease." Sci Rep 10(10018): 1–11. CKDNapp doi.org/10.1038/s41598-020-66334-w.

Pressemeldung der Uni Kiel (Juni 2021)
 

Print/Web (Auswahl)

• Deutsches Ärzteblatt - Möglicher Biomarker für eine Depression
• BILD - Kommt der Bluttest für Depressionen?
• Berliner Zeitung - Forscher finden Biomarker für Depressionen – möglicher Ansatz für Therapien
• Kieler Nachrichten - Wichtige Biomarker im Blut gefunden: Neueste Forschungen zum Thema Depressionen
• e:MedIUM Newsletter - Anzeichen von Depressionen im Blut

zudem wurde bei NDR info darüber berichtet.

• Nephro News - Apps in der Betreuung von CKD-Patienten: Die Chronic Kidney Disease Nephrologist’s App
• Deutsches Ärzteblatt - Neuer Risikorechner prognostiziert Nierenversagen
• Gesundhyte.de - die chronic kidney disease nephrologist’s app - Personalisierte Systemmedizin für Patienten mit chronischem Nierenleiden
• BMBF- Niereninsuffizienz: Neuartige App für individuelle Therapie