LeukoSyStem
Publikationen
2024
Bouman, B. J., Y. Demerdash, S. Sood, F. Grünschläger, F. Pilz, A. R. Itani, A. Kuck, V. Marot-Lassauzaie, S. Haas, L. Haghverdi, and M. A. G. Essers (2024). "Single-cell time series analysis reveals the dynamics of HSPC response to inflammation." Life Science Alliance 7(3). LeukoSyStem doi.org/10.26508/lsa.202302309.
2023
Chatziioannou, E., J. Roßner, T. N. Aung, D. L. Rimm, H. Niessner, U. Keim, L. M. Serna-Higuita, I. Bonzheim, L. Kuhn Cuellar, D. Westphal, J. Steininger, F. Meier, O. T. Pop, S. Forchhammer, L. Flatz, T. Eigentler, C. Garbe, M. Röcken, T. Amaral, and T. Sinnberg (2023). "Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases." eBioMedicine 93: 104644. MelBrainSys doi.org/10.1016/j.ebiom.2023.104644.
Dinter, L., P. C. Karitzky, A. Schulz, A. A. Wurm, M. C. Mehnert, M. Sergon, A. Tunger, M. Lesche, R. Wehner, A. Müller, T. Käubler, H. Niessner, A. Dahl, S. Beissert, M. Schmitz, F. Meier, B. Seliger, and D. Westphal (2023). "BRAF and MEK inhibitor combinations induce potent molecular and immunological effects in NRAS-mutant melanoma cells: Insights into mode of action and resistance mechanisms." International Journal of Cancer: 1-16. MelBrainSys doi.org/10.1002/ijc.34807.
Hausmann, D., D. C. Hoffmann, V. Venkataramani, E. Jung, S. Horschitz, S. K. Tetzlaff, A. Jabali, L. Hai, T. Kessler, D. D. Azoŕin, S. Weil, A. Kourtesakis, P. Sievers, A. Habel, M. O. Breckwoldt, M. A. Karreman, M. Ratliff, J. M. Messmer, Y. Yang, E. Reyhan, S. Wendler, C. Löb, C. Mayer, K. Figarella, M. Osswald, G. Solecki, F. Sahm, O. Garaschuk, T. Kuner, P. Koch, M. Schlesner, W. Wick, and F. Winkler (2023). "Autonomous rhythmic activity in glioma networks drives brain tumour growth." Nature 613: 179–186. MelBrainSys doi.org/10.1038/s41586-022-05520-4.
Karreman, M. A., A. T. Bauer, G. Solecki, A. S. Berghoff, C. D. Mayer, K. Frey, N. Hebach, M. J. Feinauer, N. L. Schieber, C. Tehranian, L. Mercier, M. Singhal, V. Venkataramani, M. C. Schubert, D. Hinze, M. Hölzel, I. Helfrich, D. Schadendorf, S. W. Schneider, D. Westphal, H. G. Augustin, J. G. Goetz, Y. Schwab, W. Wick, and F. Winkler (2023). "Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization." Cancer Res. MelBrainSys doi.org/10.1158/0008-5472.CAN-22-3964.
Kraft, T., K. Grützmann, M. Meinhardt, F. Meier, D. Westphal, and M. Seifert (2023). "Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases." Sci Rep 13(444): 1–18. MelBrainSys doi.org/10.1038/s41598-022-24940-w.
Steininger, J., F. F. Gellrich, K. Engellandt, M. Meinhardt, D. Westphal, S. Beissert, F. Meier, and I. C. Glitza Oliva (2023). "Leptomeningeal Metastases in Melanoma Patients: An Update on and Future Perspectives for Diagnosis and Treatment." International Journal of Molecular Sciences 24(14): 11443. MelBrainSys doi.org/10.3390/ijms241411443.
Westphal, D., M. Meinhardt, K. Grützmann, L. Schöne, J. Steininger, L. T. Neuhaus, M. Wiegel, D. Schrimpf, D. E. Aust, E. Schröck, G. B. Baretton, S. Beissert, T. A. Juratli, G. G. Schackert, J. Gravemeyer, J. C. Becker, A. von Deimling, C. Koelsche, B. Klink, F. Meier, A. Schulz, M. H. Muders, and M. Seifert (2023). "Identification of epigenetically regulated genes distinguishing intracranial from extracranial melanoma metastases." J Invest Dermatol. MelBrainSys doi.org/10.1016/j.jid.2023.01.011.
2022
Hernandez-Malmierca, P., D. Vonficht, A. Schnell, H. J. Uckelmann, A. Bollhagen, M. A. A. Mahmoud, S. L. Landua, E. van der Salm, C. L. Trautmann, S. Raffel, F. Grunschlager, R. Lutz, M. Ghosh, S. Renders, N. Correia, E. Donato, K. O. Dixon, C. Hirche, C. Andresen, C. Robens, P. S. Werner, T. Boch, D. Eisel, W. Osen, F. Pilz, A. Przybylla, C. Klein, F. Buchholz, M. D. Milsom, M. A. G. Essers, S. B. Eichmuller, W. K. Hofmann, D. Nowak, D. Hubschmann, M. Hundemer, C. Thiede, L. Bullinger, C. Muller-Tidow, S. A. Armstrong, A. Trumpp, V. K. Kuchroo, and S. Haas (2022). "Antigen presentation safeguards the integrity of the hematopoietic stem cell pool." Cell Stem Cell 29(5): 760-775 e710. LeukoSyStem www.ncbi.nlm.nih.gov/pubmed/35523139.
Marot-Lassauzaie, V., B. J. Bouman, F. D. Donaghy, Y. Demerdash, M. A. G. Essers, and L. Haghverdi (2022). "Towards reliable quantification of cell state velocities." PLoS Comput Biol 18(9): e1010031. LeukoSyStem doi.org/10.1371/journal.pcbi.1010031.
2021
Triana, S., D. Vonficht, L. Jopp-Saile, S. Raffel, R. Lutz, D. Leonce, M. Antes, P. Hernandez-Malmierca, D. Ordonez-Rueda, B. Ramasz, T. Boch, J. C. Jann, D. Nowak, W. K. Hofmann, C. Muller-Tidow, D. Hubschmann, T. Alexandrov, V. Benes, A. Trumpp, M. Paulsen, L. Velten and S. Haas (2021). "Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states." Nat Immunol 22(12): 1577-1589. LeukoSyStem www.ncbi.nlm.nih.gov/pubmed/34811546.
Velten, L., B. A. Story, P. Hernández-Malmierca, S. Raffel, D. R. Leonce, J. Milbank, M. Paulsen, A. Demir, C. Szu-Tu, R. Frömel, C. Lutz, D. Nowak, J.-C. Jann, C. Pabst, T. Boch, W.-K. Hofmann, C. Müller-Tidow, A. Trumpp, S. Haas and L. M. Steinmetz (2021). "Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics." Nat. Commun. 12(1366): 1–13. LeukoSyStem doi.org/10.1038/s41467-021-21650-1.
2020
Raffel, S., D. Klimmeck, M. Falcone, A. Demir, A. Pouya, P. Zeisberger, C. Lutz, M. Tinelli, O. Bischel, L. Bullinger, C. Thiede, A. Flocken, J. Westermann, G. Ehninger, A. D. Ho, C. Muller-Tidow, Z. Gu, C. Herrmann, J. Krijgsveld, A. Trumpp, and J. Hansson (2020). "Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells." BLOOD 136(13): 1507–1519. doi.org/10.1182/blood.2019003654.
In den Medien
Neuartiger Schutzmechanismus für Blutstammzellen (LeukoSyStem)
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BIH Charité Berlin - Pressemeldung (Mai 2022)
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Gesundhyte.de - Interview mit Simon Haas