Gross, A., Kracher, B., Kraus, J. M., Kuhlwein, S. D., Pfister, A. S., Wiese, S., Luckert, K., Potz, O., Joos, T., Van Daele, D., De Raedt, L., Kuhl, M.Kestler, H. A., 2019. Representing dynamic biological networks with multi-scale probabilistic models. Commun Biol, 2, 21.


Brockmann, S. J., Freischmidt, A., Oeckl, P., Müller, K., Ponna, S. K., Helferich, A. M., Paone, C., Reinders, J., Kojer, K., Orth, M., Jokela, M., Auranen, M., Udd, B., Hermann, A., Danzer, K. M., Lichtner, P., Walther, P., Ludolph, A. C., Andersen, P. M., Otto, M., Kursula, P., Just, S.Weishaupt, J. H., 2018. CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum. Mol. Genet., 27(4), 706-715.

Helferich, A. M., Brockmann, S. J., Reinders, J., Deshpande, D., Holzmann, K., Brenner, D., Andersen, P. M., Petri, S., Thal, D. R., Michaelis, J., Otto, M., Just, S., Ludolph, A. C., Danzer, K. M., Freischmidt, A.Weishaupt, J. H., 2018. Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS. Cell. Mol. Life Sci., 75(23), 4301-4319.

Hühne, R., Kessler, V., Fürstberger, A., Kühlwein, S., Platzer, M., Sühnel, J., Lausser, L.Kestler, H. A., 2018. 3D Network exploration and visualisation for lifespan data. BMC Bioinformatics, 19(1), 390.

Keßler, M., Kieltsch, A., Kayvanpour, E., Katus, H. A., Schoser, B., Schessl, J., Just, S.Rottbauer, W., 2018. A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations. Neuromuscul. Disord., 28(6), 521-531.

Kramer, F., Just, S.Zeller, T., 2018. New perspectives: systems medicine in cardiovascular disease. BMC Syst Biol, 12(1), 57.

Kramer, L. M., Brettschneider, J., Lennerz, J. K., Walcher, D., Fang, L., Rosenbohm, A., Balakrishnan, K., Benckendorff, J., Moller, P., Just, S., Willem, M., Ludolph, A. C.Thal, D. R., 2018. Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis. Sci Rep, 8(1), 16594.

Kraus, J. M., Lausser, L., Kuhn, P., Jobst, F., Bock, M., Halanke, C., Hummel, M., Heuschmann, P.Kestler, H. A., 2018. Big data and precision medicine: challenges and strategies with healthcare data. Int J Data Sci Anal, 1-9.

Kustermann, M., Manta, L., Paone, C., Kustermann, J., Lausser, L., Wiesner, C., Eichinger, L., Clemen, C. S., Schröder, R., Kestler, H. A., Sandri, M., Rottbauer, W.Just, S., 2018. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy.

Lausser, L., Siegle, L., Rottbauer, W., Frank, D., Just, S.Kestler, H. A., 2018. Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species. Biomolecules, 8(4).

Neupane, B., Zhou, Q., Gawaz, M.Gramlich, M., 2018. Personalized medicine in inflammatory cardiomyopathy. Pers. Med., 15(2), 127-136.

Paone, C., Diofano, F., Park, D.-D., Rottbauer, W.Just, S., 2018. Genetics of Cardiovascular Disease: Fishing for Causality. Front. Cardiovasc. Med., 5.

Paone, C., Rudeck, S., Etard, C., Strähle, U., Rottbauer, W.Just, S., 2018. Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response. Biochem. Biophys. Res. Commun., 496(2), 339-345.

Pott, A., Bock, S., Berger, I. M., Frese, K., Dahme, T., Keßler, M., Rinné, S., Decher, N., Just, S.Rottbauer, W., 2018. Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish. J. Mol. Cell. Cardiol., 120, 42-52.

Pott, A.Just, S., 2018. Metabolic Profiling of Glucocorticoid Deficiency: A "Fishing" Expedition. EBioMedicine, 37, 27-28.

Pott, A., Shahid, M., Köhler, D., Pylatiuk, C., Weinmann, K., Just, S.Rottbauer, W., 2018. Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish. Biomolecules, 8(4).

Schwab, J. D.Kestler, H. A., 2018. Automatic Screening for Perturbations in Boolean Networks. Front Physiol, 9, 431.

Segert, J., Schneider, I., Berger, I. M., Rottbauer, W.Just, S., 2018. Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish. Prog. Biophys. Mol. Biol., 138, 20-31.

Siegle, L., Schwab, J. D., Kühlwein, S. D., Lausser, L., Tümpel, S., Pfister, A. S., Kühl, M.Kestler, H. A., 2018. A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells. PLoS ONE, 13(3), e0195126.

Silbernagel, N., Walecki, M., Schäfer, M. K. H., Kessler, M., Zobeiri, M., Rinné, S., Kiper, A. K., Komadowski, M. A., Vowinkel, K. S., Wemhöner, K., Fortmüller, L., Schewe, M., Dolga, A. M., Scekic-Zahirovic, J., Matschke, L. A., Culmsee, C., Baukrowitz, T., Monassier, L., Ullrich, N. D., Dupuis, L., Just, S., Budde, T., Fabritz, L.Decher, N., 2018. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J., fj201800246R.

Zhou, Q., Maleck, C., von Ungern-Sternberg, S. N. I., Neupane, B., Heinzmann, D., Marquardt, J., Duckheim, M., Scheckenbach, C., Stimpfle, F., Gawaz, M., Schreieck, J., Seizer, P.Gramlich, M., 2018. Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation. Circ Arrhythm Electrophysiol, 11(6), e006242.


Lausser, L., Szekely, R., Schirra, L.-R., Kestler, H.A., 2017. The Influence of Multi-class Feature Selection on the Prediction of Diagnostic Phenotypes. Neural Process Lett 1–18.

Meyer, P., Maity, P., Burkovski, A., Schwab, J., Müssel, C., Singh, K., Ferreira, F.F., Krug, L., Maier, H.J., Wlaschek, M., Wirth, T., Kestler, H.A., Scharffetter-Kochanek, K., 2017. A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence. PLoS Comput. Biol. 13, e1005741.

Rangrez, A.Y., Hoppe, P., Kuhn, C., Zille, E., Frank, J., Frey, N., Frank, D., 2017a. MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2. PLoS ONE 12, e0183901.

Rangrez, A.Y., Pott, J., Kluge, A., Frauen, R., Stiebeling, K., Hoppe, P., Sossalla, S., Frey, N., Frank, D., 2017b. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochim. Biophys. Acta 1864, 634–644.

Schwab, J., Burkovski, A., Siegle, L., Müssel, C., Kestler, H.A., 2017. ViSiBooL-visualization and simulation of Boolean networks with temporal constraints. Bioinformatics 33, 601–604.

Zhou, Q., Schötterl, S., Backes, D., Brunner, E., Hahn, J.K., Ionesi, E., Aidery, P., Sticht, C., Labeit, S., Kandolf, R., Gawaz, M., Gramlich, M., 2017. Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy. Int. J. Cardiol. 230, 634–641.



Bühler, A., Kustermann, M., Bummer, T., Rottbauer, W., Sandri, M., Just, S., 2016. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci 17.

Hirth, S., Bühler, A., Bührdel, J.B., Rudeck, S., Dahme, T., Rottbauer, W., Just, S., 2016. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE 11, e0150323.

Hoffmann, S., Clauss, S., Berger, I.M., Weiß, B., Montalbano, A., Röth, R., Bucher, M., Klier, I., Wakili, R., Seitz, H., Schulze-Bahr, E., Katus, H.A., Flachsbart, F., Nebel, A., Guenther, S.P., Bagaev, E., Rottbauer, W., Kääb, S., Just, S., Rappold, G.A., 2016. Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. Basic Res. Cardiol. 111, 36.

Just, S., Hirth, S., Berger, I.M., Fishman, M.C., Rottbauer, W., 2016a. The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation. Biochem. Biophys. Res. Commun. 477, 581–588.

Just, S., Raphel, L., Berger, I.M., Bühler, A., Keßler, M., Rottbauer, W., 2016b. Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. PLoS ONE 11, e0167306.

Lausser, L., Schmid, F., Schirra, L.-R., Wilhelm, A.F.X., Kestler, H.A., 2016. Rank-based classifiers for extremely high-dimensional gene expression data. Adv Data Anal Classif 1–20.


Keßler, M., Rottbauer, W., Just, S., 2015. Recent progress in the use of zebrafish for novel cardiac drug discovery. Expert Opin Drug Discov 10, 1231–1241.



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