HaematoOPT

Publikationen

2020

Gottschalk, A., I. Glauche, S. Cicconi, R. E. Clark, and I. Roeder (2020). "Molecular monitoring during dose reduction predicts recurrence after TKI cessation in CML." Blood 135(10): 766–769. doi.org/10.1182/blood.2019003395.

Haehnel, T., C. Baldow, J. Guilhot, F. Guilhot, S. Saussele, S. Mustjoki, S. Jilg, P. J. Jost, S. Dulucq, F.-X. Mahon, I. Roeder, A. C. Fassoni, and I. Glauche (2020). "Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML." CANCER RESEARCH 80(11): 2394–2406. doi.org/10.1158/0008-5472.CAN-19-2175.

Hoffmann, H., C. Thiede, I. Glauche, M. Bornhaeuser, and I. Roeder (2020). "Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: insights from a mathematical modelling approach." J R Soc Interface. doi.org/10.1098/rsif.2020.0091.

Hoffmann, K., K. Cazemier, C. Baldow, S. Schuster, Y. Kheifetz, S. Schirm, M. Horn, T. Ernst, C. Volgmann, C. Thiede, A. Hochhaus, M. Bornhäuser, M. Suttorp, M. Scholz, I. Glauche, M. Loeffler, and I. Roeder (2020). "Integration of mathematical model predictions into routine workflows to support clinical decision making in haematology." BMC Med Inf Decis Making 20. doi.org/10.1186/s12911-020-1039-x.

Kheifetz, Y., and M. Scholz (2020). "Individual prediction of thrombocytopenia at next chemotherapy cycle: Evaluation of dynamic model performances." Br J Clin Pharmacol. doi.org/10.1111/bcp.14722.

Schirm, S., and M. Scholz (2020). "A biomathematical model of human erythropoiesis and iron metabolism." Sci Rep 10(8602): 1–14. doi.org/10.1038/s41598-020-65313-5.

2019

Cesar Fassoni, A., Roeder, I. and Glauche, I. (2019). "To Cure or Not to Cure: Consequences of Immunological Interactions in CML Treatment." Bull Math Biol 81(7): 2345-2395. www.ncbi.nlm.nih.gov/pubmed/31044338.

Chen, Z., Amro, E. M., Becker, F., Holzer, M., Rasa, S. M. M., Njeru, S. N., Han, B., Di Sanzo, S., Chen, Y., Tang, D., Tao, S., Haenold, R., Groth, M., Romanov, V. S., Kirkpatrick, J. M., Kraus, J. M., Kestler, H. A., Marz, M., Ori, A., Neri, F., Morita, Y. and Rudolph, K. L. (2019). "Cohesin-mediated NF-kappaB signaling limits hematopoietic stem cell self-renewal in aging and inflammation." J Exp Med 216(1): 152-175. www.ncbi.nlm.nih.gov/pubmed/30530755.

de Back, W., Zerjatke, T. and Roeder, I. (2019). "Statistical and Mathematical Modeling of Spatiotemporal Dynamics of Stem Cells." Methods Mol Biol 2017: 219-243. www.ncbi.nlm.nih.gov/pubmed/31197780.

Hoffmann, H., Thiede, C., Glauche, I., Kramer, M., Röllig, C., Ehninger, G., Bornhäuser, M. and Roeder, I. (2019). "The prognostic potential of monitoring disease dynamics in NPM1-positive acute myeloid leukemia %J Leukemia." 1. www.nature.com/articles/s41375-018-0371-y.

Kheifetz, Y. and Scholz, M. (2019). "Modeling individual time courses of thrombopoiesis during multi-cyclic chemotherapy." PLoS Comput Biol 15(3): e1006775. https://www.ncbi.nlm.nih.gov/pubmed/30840616.

2018

Fassoni, A. C., Baldow, C., Roeder, I. and Glauche, I. (2018). "Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data." Haematologica 103(11): 1825-1834. www.ncbi.nlm.nih.gov/pubmed/29954936.

Glauche, I., Kuhn, M., Baldow, C., Schulze, P., Rothe, T., Liebscher, H., Roy, A., Wang, X. and Roeder, I. (2018). "Quantitative prediction of long-term molecular response in TKI-treated CML - Lessons from an imatinib versus dasatinib comparison." Scientific Reports 8(1): 12330. www.ncbi.nlm.nih.gov/pubmed/30120281.

Gunes, C., Avila, A. I. and Rudolph, K. L. (2018). "Telomeres in cancer." Differentiation; Research in Biological Diversity 99: 41-50. www.ncbi.nlm.nih.gov/pubmed/29291448.

Schirm, S., Engel, C., Loibl, S., Loeffler, M. and Scholz, M. (2018). "Model-based optimization of G-CSF treatment during cytotoxic chemotherapy." Journal of Cancer Research and Clinical Oncology 144(2): 343-358. www.ncbi.nlm.nih.gov/pubmed/29103159.

Stasik, S., Schuster, C., Ortlepp, C., Platzbecker, U., Bornhäuser, M., Schetelig, J., Ehninger, G., Folprecht, G. and Thiede, C. (2018). "An optimized targeted Next-Generation Sequencing approach for sensitive detection of single nucleotide variants." Biomolecular Detection and Quantification 15: 6-12. www.ncbi.nlm.nih.gov/pubmed/29349042.

Suttorp, M., Schulze, P., Glauche, I., Göhring, G., von Neuhoff, N., Metzler, M., Sedlacek, P., de Bont, E. S. J. M., Balduzzi, A., Lausen, B., Aleinikova, O., Sufliarska, S., Henze, G., Strauss, G., Eggert, A., Kremens, B., Groll, A. H., Berthold, F., Klein, C., Groß-Wieltsch, U., Sykora, K. W., Borkhardt, A., Kulozik, A. E., Schrappe, M., Nowasz, C., Krumbholz, M., Tauer, J. T., Claviez, A., Harbott, J., Kreipe, H. H., Schlegelberger, B. and Thiede, C. (2018). "Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial." Leukemia. www.ncbi.nlm.nih.gov/pubmed/29925908.

2017

Baldow, C., Salentin, S., Schroeder, M., Roeder, I., Glauche, I., 2017. MAGPIE: Simplifying access and execution of computational models in the life sciences. PLoS Comput. Biol. 13, e1005898. doi.org/10.1371/journal.pcbi.1005898

Herold, S., Kuhn, M., Bonin, M.V., Stange, T., Platzbecker, U., Radke, J., Lange, T., Sockel, K., Gutsche, K., Schetelig, J., Röllig, C., Schuster, C., Roeder, I., Dahl, A., Mohr, B., Serve, H., Brandts, C., Ehninger, G., Bornhäuser, M., Thiede, C., 2017a. Donor cell leukemia-Evidence for multiple pre-leukemic clones and parallel long term clonal evolution in donor and recipient. Leukemia. doi.org/10.1038/leu.2017.104

Herold, S., Sockel, K., Sayehli, C., Herbst, R., Dührsen, U., Oelschlägel, U., Böttner, A., Hindahl, H., Kullmer, J., Helas, S., Sauer, M., Mohr, B., Mies, A., Bornhäuser, M., Ehninger, G., Röllig, C., Thiede, C., Platzbecker, U., 2017b. Evolution of NPM1-negative therapy-related myelodysplastic syndromes following curative treatment of NPM1-mutant AML. Leukemia 31, 2247–2251. doi.org/10.1038/leu.2017.217

Proschmann, R., Baldow, C., Rothe, T., Suttorp, M., Thiede, C., Tauer, J.T., Müller, M.C., Hochhaus, A., Roeder, I., Glauche, I., 2017. Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy. Haematologica 102, e39–e42. doi.org/10.3324/haematol.2016.154138

Zerjatke, T., Gak, I.A., Kirova, D., Fuhrmann, M., Daniel, K., Gonciarz, M., Mueller, D., Glauche, I., Mansfeld, J., 2017. Quantitative Cell Cycle Analysis Based on an Endogenous All-in-One Reporter for Cell Tracking and Classification. Cell Reports 19, 1953–1966. doi.org/10.1016/j.celrep.2017.05.022

2016

 

Kuhn, M., Stange, T., Herold, S., Thiede, C., Roeder, I., 2016. Finding small somatic structural variants in exome sequencing data: a machine learning approach. Comput Stat 1–14. doi.org/10.1007/s00180-016-0674-2

Schoedel, K.B., Morcos, M.N.F., Zerjatke, T., Roeder, I., Grinenko, T., Voehringer, D., Göthert, J.R., Waskow, C., Roers, A., Gerbaulet, A., 2016. The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood. doi.org/10.1182/blood-2016-03-706010

Wang, J., Morita, Y., Han, B., Niemann, S., Löffler, B., Rudolph, K.L., 2016. Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Nat. Cell Biol. 18, 480–490. doi.org/10.1038/ncb3342

 

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