open Menu
Search icon

MitoPD

Publikationen

2023

Schmidt, S., C. Stautner, D. T. Vu, A. Heinz, M. Regensburger, O. Karayel, D. Trümbach, A. Artati, S. Kaltenhäuser, M. Z. Nassef, S. Hembach, L. Steinert, B. Winner, W. Jürgen, M. Jastroch, M. D. Luecken, F. J. Theis, G. G. Westmeyer, J. Adamski, M. Mann, K. Hiller, F. Giesert, D. M. Vogt Weisenhorn, and W. Wurst (2023). "A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease." Nature Communications 14(1): 7674. doi.org/10.1038/s41467-023-42862-7.

2022

Danileviciute, E., N. Zeng, C. M. Capelle, N. Paczia, M. A. Gillespie, H. Kurniawan, M. Benzarti, M. P. Merz, D. Coowar, S. Fritah, D. M. Vogt Weisenhorn, G. Gomez Giro, M. Grusdat, A. Baron, C. Guerin, D. G. Franchina, C. Léonard, O. Domingues, S. Delhalle, W. Wurst, J. D. Turner, J. C. Schwamborn, J. Meiser, R. Krüger, J. Ranish, D. Brenner, C. L. Linster, R. Balling, M. Ollert, and F. Q. Hefeng (2022). "PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing." Nature Metabolism 4(5): 589-607. doi.org/10.1038/s42255-022-00576-y.

Schmidt, S., M. D. Luecken, D. Trümbach, S. Hembach, K. M. Niedermeier, N. Wenck, K. Pflügler, C. Stautner, A. Böttcher, H. Lickert, C. Ramirez-Suastegui, R. Ahmad, M. J. Ziller, J. C. Fitzgerald, V. Ruf, W. D. J. van de Berg, A. J. Jonker, T. Gasser, B. Winner, J. Winkler, D. M. Vogt Weisenhorn, F. Giesert, F. J. Theis, and W. Wurst (2022). "Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease." Nat Commun 13(4819): 1–25. doi.org/10.1038/s41467-022-32229-9.

2021

Blauwendraat, C., H. Iwaki, M. B. Makarious, S. Bandres-Ciga, H. L. Leonard, F. P. Grenn, J. Lake, L. Krohn, M. Tan, J. J. Kim, J. R. Gibbs, D. G. Hernandez, J. A. Ruskey, L. Pihlstrøm, M. Toft, J. J. van Hilten, J. Marinus, C. Schulte, K. Brockmann, M. Sharma, A. Siitonen, K. Majamaa, J. Eerola-Rautio, P. J. Tienari, D. G. Grosset, S. Lesage, J.-C. Corvol, A. Brice, N. Wood, J. Hardy, Z. Gan-Or, P. Heutink, T. Gasser, H. R. Morris, A. J. Noyce, M. A. Nalls and A. B. Singleton (2021). "Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease." Ann Neurol 90(1): 35–42. MitoPD doi.org/10.1002/ana.26090.

Brown, S. J., I. Boussaad, J. Jarazo, J. C. Fitzgerald, P. Antony, M. Keatinge, J. Blechman, J. C. Schwamborn, R. Krüger, M. Placzek and O. Bandmann (2021). "PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons." Sci. Rep. 11(6617): 1–14. MitoPD https://doi.org/10.1038/s41598-021-84278-7.

Kia, D. A., D. Zhang and S. Guelfi (2021). "Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression." JAMA Neurol. 78(4): 464–472. MitoPD doi.org/10.1001/jamaneurol.2020.5257.

2020

Boussaad, I., C. D. Obermaier, Z. Hanss, D. R. Bobbili, S. Bolognin, E. Glaab, K. Wołyńska, N. Weisschuh, L. De Conti, C. May, F. Giesert, D. Grossmann, A. Lambert, S. Kirchen, M. Biryukov, L. F. Burbulla, F. Massart, J. Bohler, G. Cruciani, B. Schmid, A. Kurz-Drexler, P. May, S. Duga, C. Klein, J. C. Schwamborn, K. Marcus, D. Woitalla, D. M. Vogt Weisenhorn, W. Wurst, M. Baralle, D. Krainc, T. Gasser, B. Wissinger, and R. Krüger (2020). "A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease." Sci Transl Med 12(560): eaau3960. doi.org/10.1126/scitranslmed.aau3960.

Bus, C., L. Zizmare, M. Feldkaemper, S. Geisler, M. Zarani, A. Schaedler, F. Klose, J. Admard, C. J. Mageean, G. Arena, P. Fallier-Becker, A. Ugun-Klusek, K. K. Maruszczak, K. Kapolou, B. Schmid, D. Rapaport, M. Ueffing, N. Casadei, R. Krüger, T. Gasser, D. M. Vogt Weisenhorn, P. J. Kahle, C. Trautwein, C. J. Gloeckner, and J. C. Fitzgerald (2020). "Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors." iScience 23(12): 101797. doi.org/10.1016/j.isci.2020.101797.

Garrett, L., Y. J. Chang, K. M. Niedermeier, T. Heermann, W. Enard, H. Fuchs, V. Gailus-Durner, M. H. de Angelis, W. B. Huttner, W. Wurst, and S. M. Hölter (2020). "A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons." Transl Psychiatry 10(1): 1--14. www.nature.com/articles/s41398-020-0686-0.

Nothias, L.-F., D. Petras, R. Schmid, K. Dührkop, J. Rainer, A. Sarvepalli, I. Protsyuk, M. Ernst, H. Tsugawa, M. Fleischauer, F. Aicheler, A. A. Aksenov, O. Alka, P.-M. Allard, A. Barsch, X. Cachet, A. M. Caraballo-Rodriguez, R. R. Da Silva, T. Dang, N. Garg, J. M. Gauglitz, A. Gurevich, G. Isaac, A. K. Jarmusch, Z. Kameník, K. B. Kang, N. Kessler, I. Koester, A. Korf, A. Le Gouellec, M. Ludwig, C. Martin H., L.-I. McCall, J. McSayles, S. W. Meyer, H. Mohimani, M. Morsy, O. Moyne, S. Neumann, H. Neuweger, N. H. Nguyen, M. Nothias-Esposito, J. Paolini, V. V. Phelan, T. Pluskal, R. A. Quinn, S. Rogers, B. Shrestha, A. Tripathi, J. J. J. van der Hooft, F. Vargas, K. C. Weldon, M. Witting, H. Yang, Z. Zhang, F. Zubeil, O. Kohlbacher, S. Böcker, T. Alexandrov, N. Bandeira, M. Wang, and P. C. Dorrestein (2020). "Feature-based molecular networking in the GNPS analysis environment." Nat Methods 17(9): 905–908. doi.org/10.1038/s41592-020-0933-6.

2019

Blauwendraat, C., Heilbron, K., Vallerga, C. L., Bandres-Ciga, S., von Coelln, R., Pihlstrom, L., Simon-Sanchez, J., Schulte, C., Sharma, M., Krohn, L., Siitonen, A., Iwaki, H., Leonard, H., Noyce, A. J., Tan, M., Gibbs, J. R., Hernandez, D. G., Scholz, S. W., Jankovic, J., Shulman, L. M., Lesage, S., Corvol, J. C., Brice, A., van Hilten, J. J., Marinus, J., andMe Research, T., Eerola-Rautio, J., Tienari, P., Majamaa, K., Toft, M., Grosset, D. G., Gasser, T., Heutink, P., Shulman, J. M., Wood, N., Hardy, J., Morris, H. R., Hinds, D. A., Gratten, J., Visscher, P. M., Gan-Or, Z., Nalls, M. A., Singleton, A. B. and International Parkinson's Disease Genomics, C. (2019). "Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and alpha-synuclein mechanisms." Mov Disord 34(6): 866-875. www.ncbi.nlm.nih.gov/pubmed/30957308.

Fecher, C., Trovo, L., Muller, S. A., Snaidero, N., Wettmarshausen, J., Heink, S., Ortiz, O., Wagner, I., Kuhn, R., Hartmann, J., Karl, R. M., Konnerth, A., Korn, T., Wurst, W., Merkler, D., Lichtenthaler, S. F., Perocchi, F. and Misgeld, T. (2019). "Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity." Nat Neurosci 22(10): 1731-1742. www.ncbi.nlm.nih.gov/pubmed/31501572.

Glaab, E., Trezzi, J. P., Greuel, A., Jager, C., Hodak, Z., Drzezga, A., Timmermann, L., Tittgemeyer, M., Diederich, N. J. and Eggers, C. (2019). "Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease." Neurobiol Dis 124: 555-562. www.ncbi.nlm.nih.gov/pubmed/30639291.

Grossmann, D., Berenguer-Escuder, C., Bellet, M. E., Scheibner, D., Bohler, J., Massart, F., Rapaport, D., Skupin, A., Fouquier d'Herouel, A., Sharma, M., Ghelfi, J., Rakovic, A., Lichtner, P., Antony, P., Glaab, E., May, P., Dimmer, K. S., Fitzgerald, J. C., Gruenewald, A. and Kruger, R. (2019). "Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease." Antioxid Redox Signal. www.ncbi.nlm.nih.gov/pubmed/31303019.

Heermann, T., Garrett, L., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Graw, J. and Hölter, S. M. (2019). "Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice." Molecular Neurobiology 56(6): 4215-4230. www.ncbi.nlm.nih.gov/pubmed/30291584.

Hollerhage, M., Fussi, N., Rosler, T. W., Wurst, W., Behrends, C. and Hoglinger, G. U. (2019). "Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons." Neuropharmacology 149: 13-26. www.ncbi.nlm.nih.gov/pubmed/30731136.

van Well, E. M., Bader, V., Patra, M., Sanchez-Vicente, A., Meschede, J., Furthmann, N., Schnack, C., Blusch, A., Longworth, J., Petrasch-Parwez, E., Mori, K., Arzberger, T., Trumbach, D., Angersbach, L., Showkat, C., Sehr, D. A., Berlemann, L. A., Goldmann, P., Clement, A. M., Behl, C., Woerner, A. C., Saft, C., Wurst, W., Haass, C., Ellrichmann, G., Gold, R., Dittmar, G., Hipp, M. S., Hartl, F. U., Tatzelt, J. and Winklhofer, K. F. (2019). "A protein quality control pathway regulated by linear ubiquitination." EMBO J 38(9). www.ncbi.nlm.nih.gov/pubmed/30886048.

2018

Fussi, N., Höllerhage, M., Chakroun, T., Nykänen, N.-P., Rösler, T. W., Koeglsperger, T., Wurst, W., Behrends, C. and Höglinger, G. U. (2018). "Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy." Cell Death & Disease 9(7): 757. www.ncbi.nlm.nih.gov/pubmed/29988147.

Garrett, L., Becker, L., Rozman, J., Puk, O., Stoeger, T., Yildirim, A. Ö., Bohla, A., Eickelberg, O., Hans, W., Prehn, C., Adamski, J., Klopstock, T., Rácz, I., Zimmer, A., Klingenspor, M., Fuchs, H., Gailus-Durner, V., Wurst, W., Hrabě de Angelis, M., Graw, J. and Hölter, S. M. (2018). "Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice." Molecular Neurobiology 55(6): 4580-4595. www.ncbi.nlm.nih.gov/pubmed/28695538.

Glaab, E. (2018). "Computational systems biology approaches for Parkinson's disease." Cell and Tissue Research 373(1): 91-109. www.ncbi.nlm.nih.gov/pubmed/29185073.

Jung, P. P., Zhang, Z., Paczia, N., Jaeger, C., Ignac, T., May, P. and Linster, C. L. (2018). "Natural variation of chronological aging in theSaccharomyces cerevisiaespecies reveals diet-dependent mechanisms of life span control." NPJ aging and mechanisms of disease 4: 3. www.ncbi.nlm.nih.gov/pubmed/29560271.

Rotermund, C., Machetanz, G. and Fitzgerald, J. C. (2018). "The Therapeutic Potential of Metformin in Neurodegenerative Diseases." Frontiers in Endocrinology 9. www.frontiersin.org/articles/10.3389/fendo.2018.00400/full.

Zimprich, A., Östereicher, M. A., Becker, L., Dirscherl, P., Ernst, L., Fuchs, H., Gailus-Durner, V., Garrett, L., Giesert, F., Glasl, L., Hummel, A., Rozman, J., de Angelis, M. H., Vogt-Weisenhorn, D., Wurst, W. and Hölter, S. M. (2018). "Analysis of locomotor behavior in the German Mouse Clinic." Journal of Neuroscience Methods 300: 77-91. www.ncbi.nlm.nih.gov/pubmed/28483715.

2017

Ashrafi, A., Garcia, P., Kollmus, H., Schughart, K., Del Sol, A., Buttini, M., Glaab, E., 2017. Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson’s disease. Neurobiol. Aging 58, 30–33. doi.org/10.1016/j.neurobiolaging.2017.06.008

Garrett, L., Becker, L., Rozman, J., Puk, O., Stoeger, T., Yildirim, A.Ö., Bohla, A., Eickelberg, O., Hans, W., Prehn, C., Adamski, J., Klopstock, T., Rácz, I., Zimmer, A., Klingenspor, M., Fuchs, H., Gailus-Durner, V., Wurst, W., Hrabě de Angelis, M., Graw, J., Hölter, S.M., 2017. Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice. Mol. Neurobiol. doi.org/10.1007/s12035-017-0659-3

Giesert, F., Glasl, L., Zimprich, A., Ernst, L., Piccoli, G., Stautner, C., Zerle, J., Hölter, S.M., Vogt Weisenhorn, D.M., Wurst, W., 2017. The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson’s disease in the mouse. Neurobiol. Dis. 105, 179–193. doi.org/10.1016/j.nbd.2017.05.013

Jansen, I.E., Gibbs, J.R., Nalls, M.A., Price, T.R., Lubbe, S., van Rooij, J., Uitterlinden, A.G., Kraaij, R., Williams, N.M., Brice, A., Hardy, J., Wood, N.W., Morris, H.R., Gasser, T., Singleton, A.B., Heutink, P., Sharma, M., 2017a. Establishing the role of rare coding variants in known Parkinson’s disease risk loci. Neurobiology of Aging. doi.org/10.1016/j.neurobiolaging.2017.07.009

Jansen, I.E., Ye, H., Heetveld, S., Lechler, M.C., Michels, H., Seinstra, R.I., Lubbe, S.J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J.R., Nalls, M.A., Ryten, M., Botia, J.A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., Chouhan, A.K., Li, Y., Yogi, P., Amin, N., van Duijn, C.M., International Parkinson’s Disease Genetics Consortium (IPGDC), Morris, H.R., Brice, A., Singleton, A.B., David, D.C., Nollen, E.A., Jain, S., Shulman, J.M., Heutink, P., 2017b. Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing. Genome Biol. 18, 22. doi.org/10.1186/s13059-017-1147-9

Pfeuffer, J., Sachsenberg, T., Alka, O., Walzer, M., Fillbrunn, A., Nilse, L., Schilling, O., Reinert, K., Kohlbacher, O., 2017. OpenMS - A platform for reproducible analysis of mass spectrometry data. J. Biotechnol. 261, 142–148. doi.org/10.1016/j.jbiotec.2017.05.016

Salminen, A.V., Garrett, L., Schormair, B., Rozman, J., Giesert, F., Niedermeier, K.M., Becker, L., Rathkolb, B., Rácz, I., German Mouse Clinic Consortium, Klingenspor, M., Klopstock, T., Wolf, E., Zimmer, A., Gailus-Durner, V., Torres, M., Fuchs, H., Hrabě de Angelis, M., Wurst, W., Hölter, S.M., Winkelmann, J., 2017. Meis1: effects on motor phenotypes and the sensorimotor system in mice. Dis Model Mech 10, 981–991. doi.org/10.1242/dmm.030080

Zanon, A., Kalvakuri, S., Rakovic, A., Foco, L., Guida, M., Schwienbacher, C., Serafin, A., Rudolph, F., Trilck, M., Gruenewald, A., Stanslowsky, N., Wegner, F., Giorgio, V., Lavdas, A.A., Bodmer, R., Pramstaller, P.P., Klein, C., Hicks, A.A., Pichler, I., Seibler, P., 2017. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum. Mol. Genet. 26, 2412–2425. doi.org/10.1093/hmg/ddx132

 

2016

Vogt Weisenhorn, D.M., Giesert, F., Wurst, W., 2016. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson’s Disease. J. Neurochem. 139 Suppl 1, 8–26. doi.org/10.1111/jnc.13670

Wüst, R., Maurer, B., Hauser, K., Woitalla, D., Sharma, M., Krüger, R., 2016. Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson’s disease. Neurobiol. Aging 39, 217.e13-15. doi.org/10.1016/j.neurobiolaging.2015.11.025

MitoPD-Projekte in den Medien: