Diosa-Toro, M., Troost, B., van de Pol, D., Heberle, A. M., Urcuqui-Inchima, S., Thedieck, K.Smit, J. M., 2019. Tomatidine, a novel antiviral compound towards dengue virus. Antiviral Res., 161, 90-99.

Otto, R., Rossler, J. N., Sers, C., Mamlouk, S.Leser, U., 2019. Robust in-silico identification of Cancer Cell Lines based on RNA and targeted DNA sequencing data. Sci Rep, 9(1), 367.


Dorel, M., Klinger, B., Gross, T., Sieber, A., Prahallad, A., Bosdriesz, E., Wessels, L. F. A.Blüthgen, N., 2018. Modelling signalling networks from perturbation data. Bioinformatics, 34(23), 4079-4086.

Li, Y., Finkbeiner, S., Ganner, A., Gerber, J., Klein, M., Grafe, M., Kandzia, J., Thien, A., Thedieck, K., Breves, G., Jank, T., Baumeister, R., Walz, G.Neumann-Haefelin, E., 2018. CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans. Oncotarget, 9(11), 9581-9595.

Seva, J., Wackerbauer, M. and Leser, U. (2018) Identifying Key Sentences for Precision Oncology Using Semi-Supervised Learning, BioNLP 2018 workshop. Melbouren, Australia, July 2018.

Shafiee Kamalabad, M., Heberle, A. M., Thedieck, K.Grzegorczyk, M., 2018. Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices. Bioinformatics.

Starlinger, J., Pallarz, S., Ševa, J., Rieke, D., Sers, C., Keilholz, U.Leser, U., 2018. Variant information systems for precision oncology %J BMC Med. Inf. Decis. Making. 18(1), 107.

Weise, S. C., Villarreal, A., Heidrich, S., Dehghanian, F., Schachtrup, C., Nestel, S., Schwarz, J., Thedieck, K.Vogel, T., 2018. TGFβ-Signaling and FOXG1-Expression Are a Hallmark of Astrocyte Lineage Diversity in the Murine Ventral and Dorsal Forebrain. Front Cell Neurosci, 12.

Witzel, F.Blüthgen, N., 2018. When More Is Less: Dual Phosphorylation Protects Signaling Off State against Overexpression. Biophys. J., 115(7), 1383-1392.


Klinghammer, K., Otto, R., Raguse, J.-D., Albers, A. E., Tinhofer, I., Fichtner, I., Leser, U., Keilholz, U. Hoffmann, J., 2017. Basal subtype is predictive for response to cetuximab treatment in patient-derived xenografts of squamous cell head and neck cancer, J Int. J. Cancer, 141(6), 1215--1221.

Otto, R., Sers, C., Leser, U., 2017. Robust in-silico identification of cancer cell lines based on next generation sequencing. Oncotarget 8, 34310–34320.

Razquin Navas, P., Thedieck, K., 2017. Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network. Essays Biochem. 61, 349–368.

Ruf, S., Heberle, A.M., Langelaar-Makkinje, M., Gelino, S., Wilkinson, D., Gerbeth, C., Schwarz, J.J., Holzwarth, B., Warscheid, B., Meisinger, C., van Vugt, M.A.T.M., Baumeister, R., Hansen, M., Thedieck, K., 2017. PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy 13, 486–505.

Thobe, K., Sers, C., Siebert, H., 2017. Unraveling the regulation of mTORC2 using logical modeling. Cell Commun. Signal. 15, 6.

Uhlitz, F., Sieber, A., Wyler, E., Fritsche-Guenther, R., Meisig, J., Landthaler, M., Klinger, B., Blüthgen, N., 2017. An immediate-late gene expression module decodes ERK signal duration. Mol. Syst. Biol. 13, 928.



Clark, C.A., Gupta, H.B., Sareddy, G., Pandeswara, S., Lao, S., Yuan, B., Drerup, J.M., Padron, A., Conejo-Garcia, J., Murthy, K., Liu, Y., Turk, M.J., Thedieck, K., Hurez, V., Li, R., Vadlamudi, R., Curiel, T.J., 2016. Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma. Cancer Res. 76, 6964–6974.

Pezze, P.D., Ruf, S., Sonntag, A.G., Langelaar-Makkinje, M., Hall, P., Heberle, A.M., Navas, P.R., van Eunen, K., Tölle, R.C., Schwarz, J.J., Wiese, H., Warscheid, B., Deitersen, J., Stork, B., Fäßler, E., Schäuble, S., Hahn, U., Horvatovich, P., Shanley, D.P., Thedieck, K., 2016. A systems study reveals concurrent activation of AMPK and mTOR by amino acids. Nat Commun 7, 13254.


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