Preliminary Program

Session 1:

Systems Medicine of Diseases I

Spot Light Talk: Application of CRISPR Screening in Cancer Systems Medicine

Hippo-YAP pathway activation favors neuroblastoma progression

The influence of the bone marrow niche on drug response phenotypes of blood cancers

Session 2:

Technologies in Systems Medicine

Keynote talk

VIS – an Integrated Knowledge Base for Precision Oncology

A data-driven approach to discover novel biomarkers by investigating complex immune cell patterns in multiple tissue sections stained for immuno-oncology markers

Assessment of donor-reactive T-cell immunity by the novel urine cell-derived alloantigen assay allows prediction of acute rejection in renal transplant patients

Pinpointing disease-causing regulatory genetic variants by multi-omics and machine learning

Session 3:

Systems medicine of diseases II

Keynote lecture

Syphad Database:

a pharmacological big data approach

Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

Identification of novel smoking-regulated DNA methylation sites – the GPR15 locus as a marker for cigarette smoking?

Disease progression in Crohn’s disease is linked to early patterns in the transcriptome, epigenome and microbiome

Session 4:

Modelling in Systems Medicine

Keynote lecture

A mathematical approach towards immunological control of minimal residual disease in CML patients

Quantification of cell cycle speed in fast dividing cells in vivo

Modelling TERT regulation in prostate cancer leads to new prognostic markers

Treatment of metastatic uveal melanoma directed by a comprehensive genomic and transcriptomic tumour analysis and mechanistic computational modelling of drug response predictions.

Session 5:

Translational Approaches in Systems Medicine

Keynote Lecture

Genomic High-throughput Sequencing in Precision Medicine: A Survey on Public Knowledge, Attitudes, Expectations, and Fears

Heterogeneity and dynamics of the tumor-infiltrating lymphocyte repertoire in melanoma and pancreatic cancer patients

Adaptation of cancer cells to nutritional stress induced by Trp degrading enzymes via GCN2-peIF2a-ATF4-mediated upregulation of tryptophanyl-tRNA-synthetase

Multi-region sequencing dissects intratumor heterogeneity in neuroblastoma

1

P1: Delineating the dynamic transcriptome

response of mRNA and microRNA during

zebrafish heart regeneration

2

P19: Using bayesian MTMK-learning to predict

drug efficacy in colorectal cancer

3

P27: Microbiota changes in individuals at high risk

for the development of inflammatory bowel

disease

4

P53: Personalized treatment planning in Aortic

Valve Disease

5

P55: Long-QT induced bradycardia in zebrafish

hiphop mutant – Na+/K+-ATPase as a key

regulator of myocardial repolarization?

6

P59: Prediction of therapeutic drug response by

proteomic activation profiling of HER2 low

breast cancer

7

P61: Implementing a multilayer framework for

pathway data integration, analysis and

visualization

8

P71: Surrogate minimal depth as an importance

measure for variables in random forests

9

P81: Cooperative STAT/NF-κB signaling regulates

lymphoma metabolic reprogramming and

aberrant GOT2 expression

10

P95: Data-independent acquisition analysis of the

mitochondrial proteome to identify

quantitative, disease-specific signatures

11

P79: Systematic identification of human aryl

hydrocarbon receptor (AHR) targets to

determine AHR activation in diverse

physiological and pathophysiological

conditions

1

P74: INCOME – Improving collaborative research by

model re-use, extension and integration

2

P16: Circular RNAs contribute to the pathogenesis of

neuroblastoma

3

P18: Gene expression analysis of anti-HER

therapeutics in gastric cancer cell lines

4

P32: Whole exome sequencing of multiplex bipolar

disorder families and follow-up resequencing

implicate rare variants in cell adhesion genes

contributing to disease etiology

5

P42: Automated targeted multi-scale imaging of

tissue microarrays for telomere analysis in

prostate cancer

6

P48: Methylation based classifier for brain tumors

substantially improves diagnostic precision

7

P56: Integrating lipidomics and proteomics data in

metabolic model of adipose tissue

8

P58: Multi-level mathematical model simulations

used to predict key host and pathogen

determinants of successful early lung

pneumococcal infection

9

P68: Unraveling the prognostic potential of

inflammatory patterns in the breast tumor

microenvironment: a modeling framework

10

P94: High-throughput antibody-based profiling of

serum in psychiatric patients: implications for

the prediction of clinical outcome

11

P96: Resting state fMRI based target selection for

personalized rTMS: stimulation over the left

DLPFC temporarily alters the default mode

network in healthy subjects