The e:Med Meeting 2022 will be held at the Communication Center at DKFZ Heidelberg.
The program will include exciting news from System Medicine research, outstanding keynote speakers, space for active participation of the e:Med community and plenty of time for networking.


Preliminary Program

as at 2022-11-23:

Monday, November 28, 2022

Mon Nov 28 Topic Speaker

11:45 - 01:15 pm

Welcome Supper

01:15 - 01:30 pm

Welcome Speeches

Nicola Scholz, BMBF

Michael Boutros, DKFZ

Julie George and

Rainer Spanagel,

e:Med PK Spokespersons

01:30 - 02:15 pm

Keynote Lecture:

Genomic Variation and Disease

Markus Nöthen,

University Hospital of Bonn

02:15 - 02:45 pm

Technologies in Systems Medicine

02:15 - 02:30 pm

An online knowledge base for network based mechanism exploration and drug repurposing in oncology

Michael Hartung,

University of Hamburg

02:30 - 02:45 pm

Shallow nanopore RNA sequencing enables transcriptome profiling for precision cancer medicine

Cihan Erkut,



02:45 - 03:15 pm

Coffee Break

03:15 - 03:45 pm

Technologies in Systems Medicine

03:15 - 03:30 pm

Enhancing Neoantigen Expression in Small Cell Lung Cancer via Inhibition of Nonsense-Mediated Decay

Lucia A. Torres


University of Cologne

03:30 - 03:45 pm

Stability of feature selection utilizing Graph Convolutional Neural Network and Layer-wise Relevance Propagation

Hryhorii Chereda,

University Medical

Center Göttingen

03:45 - 05:00 pm

Poster Session I


03:45 - 04:15 pm

Poster Flash Talks I

10 Talks

04:15 - 05:00 pm

Poster Discussion I


05:00 - 06:15 pm

Bioinformatic Approaches in Systems Medicine

05:00 - 05:15 pm

Machine learning for treatment optimization in personalized medicine

Stefan Schrod,

University Medical

Center Göttingen

05:15 - 05:30 pm

From black box to grey box - How to shed light on Variational Autoencoder models

Daria Doncevic,

Heidelberg University

05:30 - 05:45 pm

From alternative splicing events to mechanistic insights

Olga Tsoy,

University of Hamburg

05:45 - 06:00 pm

UnPaSt: Identification of differentially expressed biclusters for unsupervised patient stratification

Olga Zolotareva,

University of Hamburg;

Technical University of


06:00 - 06:15 pm

Personalized prediction of mortality risks in chronic kidney disease patients

Bence Oláh,

TU Braunschweig and

Hannover Medical School

06:15 - 07:00 pm

Evening Lecture Climate:

Taking Earth's Temperature

Bjorn Stevens


for Meteorology,


07:00 - open end

Mocktails Hour

Live Music and Appetizers

Tuesday, November 29, 2022

Tue Nov 29 Topic Speaker

09:00 - 09:30 am

Keynote Lecture: Individual-specific networks: wonder networks or something to wonder about?

Kristel Van Steen,

KU Leuven,

Université de Liège

09:30 - 10:15 am

Modeling in Systems Medicine

09:30 - 09:45 am

A guide to the Computational Modeling in Biology Network (COMBINE): Navigating through specifications, mailing lists and tools

Dagmar Waltemath,

University Medicine


09:45 - 10:00 am

OMIBONE: OMIcs-driven computer model of BOne regeNEration for personalized treatment

Mahdi Jaber,



10:00 - 10:15 am

Improving our Mechanistic Understanding of Cell Cycle Dynamics

Paul Lang,

University of


10:15 - 10:30 am

Company Talk

10:30 - 11:00 am

Coffee Break

11:00 - 11:45 am

Modeling in Systems Medicine

11:00 - 11:15 am

Basis of molecular-medicine based reporting in IBD therapy guidance – Experiences from the GUIDE-IBD trial

Florian Tran

University Hospital Schleswig

Holstein, Kiel

11:15 - 11:30 am

Multi-stage model facilities assessment of the spread of breast cancer metastasis

Jan Hasenauer,

University of Bonn

11:30 - 11:45 am

Elucidating the temporal regulation of IKK/ NF-kB signaling upon genotoxic stress by computational modeling

Fabian Konrath,

Jana Wolf,


Center, Berlin

11:45 - 12:15 pm

PG Networking:

- PG Data Security and Ethics

- PG Modeling of Disease Process

- PG MS- and NMR-based Omics

Project Group Members:

- Jan Baumbach, Stephanie Witt

- Jana Wolf, Sara Checa

- Stefan Kalkhof,

Helena Zacharias

12:15 - 01:30 pm

Lunch break

01:30 - 02:00 pm

Keynote Lecture: Redefining diseases for precision diagnosis and drug repurposing

Harald HHW Schmidt,



02:00 - 02:45 pm

Systems Medicine of Diseases

02:00 - 02:15 pm

Dysregulated Energy Balance Impairs Scaffold-Guided Bone Regeneration In Type 2 Diabetes

Daniela Bastos Dias,



02:15 - 02:30 pm

Early molecular signatures of therapeutic response to vedolizumab therapy in Inflammatory Bowel Disease patients identified using a longitudinal multi-omics approach

Neha Mishra,


University Kiel;

University Medical



02:30 - 02:45 pm

Network-based enrichment analysis of molecular data from large-scale disease maps

Matti Hoch,

University of Rostock

02:45 - 03:15 pm

Coffee Break

03:15 - 03:45 pm

Systems Medicine of Diseases

03:15 - 03:30 pm

Stromaless organoids of mammary ductal carcinoma in situ suggest that myoepithelial cells are an integral part of premalignant breast lesions

Stefan Florian,



03:30 - 03:45 pm

A step closer to Personalized Medicine: the application of a gnotobiotic mouse model to investigate the role of the microbiome in IBD-therapy

Martina Guggeis, Kiel University

03:45 - 4:00 pm

Olink Proteomics for systems

biology: Rise of Precision

Proteomics in Integrated Multiomics

Rutuja Patwardhan

Company Talk Olink

04:00 - 05:15 pm

Poster Session II

04:00 - 04:30 pm

Poster Flash Talks II

10 Talks

04:30 - 05:15 pm

Poster Discussion II


05:15 - 05:45 pm

Keynote: Decoding the developing human immune system

Muzlifah Haniffa,

Sanger Institute

05:45 - 06:30 pm

Systems Medicine of Diseases

05:45 - 06:00 pm

Targeting network communication to inhibit melanoma brain metastatic growth in vivo

Matthia A. Karreman,



DKFZ, Heidelberg

06:00 - 06:15 pm

Tryptophan catabolism associates with severity and long-term disease control in chronic inflammatory diseases

Danielle Harris,



06:15 - 06:30 pm

Disease stage-related cellular and molecular markers identified in patients with idiopathic pulmonary fibrosis

Jiangyan Yu,

University of Bonn

06:30 open end

Conference Dinner and Networking



Wednesday, November 30, 2022

Wed Nov 30 Topic Speaker

09:00 - 09:30 am

Keynote Lecture: Assessing

intra-tumoral heterogeneity

in genetically simple tumors -

what can we learn?

Pfister Stefan,



09:30 - 10:15 am

Translational Approaches in

Systems Medicine

09:30 - 09:45 am

Patient derived organoids

demonstrate hallmark

characteristics of small cell

lung cancer for therapeutic

screening and functional


Joshua D'Rozario,

University Hospital

of Cologne

09:45 - 10:00 am

Integration of systems, network

and machine learning modeling

to select tumor-associated

antigens for immunotherapy in

metastatic melanoma

Julio Vera,

UK Erlangen;

FAU Erlangen-


10:00 - 10:15 am

Senescence systems medicine

for individualized lymphoma


Clemens A. Schmitt,

Charité Berlin

10:15 - 10:30 am

The Use of Novel Proteograph

Technology to facilitate in-depth

exploration of the Proteome at

Scale and Speed.

Richard Broadhead

Company Talk Life & Brain

10:30 - 11:00 am

Coffee Break

11:00 - 11:45 am

Translational Approaches in

Systems Medicine

11:00 - 11:15 am

Transcriptomic signatures in

AUD - a translational approach

Marion Friske,

Central Institute of

Mental Health,


11:15 - 11:30 am

Immunogenicity of primary

tumor cell lines derived from

melanoma brain metastases

Nusrat Yasmin,

Technische Universität


11:30 - 11:45 am

Activation of metaphyseal

progenitor cells in bone marrow

fibrosis drives the fibrotic

transformation via a Wnt axis

Bella Banjanin,

Erasmus MC

11:45 - 12:00 pm

Breaking News:

Spatial cellular networks from

omics data

Michael Altenbuchinger,

University Medical Center


12:00 - 12:15 pm

Highly accurate (and affordable!)

long reads in biomedical research

Thea Ziegler

Company Talk PacBio

12:15 - 01:15 pm


01:15 - 01:45 pm

Molecular Disease Board

From neoplasms to non-clonal diseases

Daniel Huebschmann

Peter Horak

Wolfgang Merkt

Philip Rosenstiel

01:45 - 02:15 pm

Award Ceremony &

Closing Remarks

e:Med Poster and

Creative Award

02:15 - 03:15 pm

Project Committee Meeting

By invitation only

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