High-Through-Put Data Generation and Integrated Data Analysis
The obtained and pathologically evaluated tumor material in TP1 is then analyzed by various high-throughput analysis. In particular all tumors and control tissues (blood) will undergo genome sequencing. Likewise, the genomes of xenograft models of TP3 are sequenced. Additionally, we will carry out transcriptome and methylome analysis of primary tumors and xenograft-models
These results are then put into context with available clinical data and the results of the other TPs in order to develop subtype-specific, prognostic biomarkers, which can then be checked in the other subprojects. Here, the in-depth characterization of the genome, transcriptome and methylome of the tumors will be the foundation for the network analysis and dynamic modeling within TP4.