SYMPATH
Publications
2023
Asmus, E., W. Karle, M. C. Brack, C. Wittig, F. Behrens, L. Reinshagen, M. Pfeiffer, S. Schulz, B. Mandzimba-Maloko, L. Erfinanda, P. L. Perret, L. Michalick, P. J. Smeele, E. H. T. Lim, C. E. van den Brom, A. B. A. Vonk, T. Kaiser, N. Suttorp, S. Hippenstiel, L. E. Sander, F. Kurth, U. Rauch, U. Landmesser, A. Haghikia, R. Preissner, H. J. Bogaard, M. Witzenrath, W. M. Kuebler, R. Szulcek, and S. Simmons (2023). "Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients." European Respiratory Journal 61(3). doi.org/10.1183/13993003.02009-2022.
Beuchel, C., J. Dittrich, S. Becker, H. Kirsten, A. Tönjes, P. Kovacs, M. Stumvoll, M. Loeffler, A. Teren, J. Thiery, B. Isermann, U. Ceglarek, and M. Scholz (2023). "An atlas of genome-wide gene expression and metabolite associations and possible mediation effects towards body mass index." Journal of Molecular Medicine 101: 1-17. doi.org/10.1007/s00109-023-02362-z.
Felten, M., C. Dame, G. Lachmann, C. Spies, K. Rubarth, F. Balzer, A. Kramer, and M. Witzenrath (2023). "Circadian Rhythm Disruption in Critically Ill Patients." Acta Physiol n/a(n/a): e13962. doi.org/10.1111/apha.13962.
Goekeri, C., P. Pennitz, W. Groenewald, U. Behrendt, H. Kirsten, C. M. Zobel, S. Berger, G. A. Heinz, M.-F. Mashreghi, S.-M. Wienhold, K. Dietert, A. Dorhoi, A. D. Gruber, M. Scholz, G. Rohde, N. Suttorp, C. S. Group, M. Witzenrath, and G. Nouailles (2023). "MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia." Cells 12(6): 959. doi.org/10.3390/cells12060959.
Kucherenko, M. M., P. C. Sang, J. Q. Yao, T. Gransar, S. Dhital, J. Grune, S. Simmons, L. Michalick, D. Wulsten, M. Thiele, O. Shomroni, F. Hennig, R. Yeter, N. Solowjowa, G. Salinas, G. N. Duda, V. Falk, N. R. Vyavahare, W. M. Kuebler, and C. Knosalla (2023). "Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease." Nature Communications 14(1). doi.org/10.1038/s41467-023-39934-z.
Nouailles, G., J. M. Adler, P. Pennitz, S. Peidli, L. G. Teixeira Alves, M. Baumgardt, J. Bushe, A. Voss, A. Langenhagen, C. Langner, R. Martin Vidal, F. Pott, J. Kazmierski, A. Ebenig, M. V. Lange, M. D. Mühlebach, C. Goekeri, S. Simmons, N. Xing, A. Abdelgawad, S. Herwig, G. Cichon, D. Niemeyer, C. Drosten, C. Goffinet, M. Landthaler, N. Blüthgen, H. Wu, M. Witzenrath, A. D. Gruber, S. D. Praktiknjo, N. Osterrieder, E. Wyler, D. Kunec, and J. Trimpert (2023). "Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters." Nat Microbiol: 1–15. doi.org/10.1038/s41564-023-01352-8.
Pennitz, P., C. Goekeri, J. Trimpert, E. Wyler, A. Ebenig, C. Weissfuss, M. D. Mühlebach, M. Witzenrath, and G. Nouailles (2023). "Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis." STAR Protocols 4(1): 101957. doi.org/10.1016/j.xpro.2022.101957.
Setiawan, D. C. B., S. Simmons, L. Michalick, and W. M. Kuebler (2023). "Implementation of Recommendations for Features and Measurements of Experimental Acute Lung Injury." American Journal of Respiratory Cell and Molecular Biology 69(4): 484-487. doi.org/10.1165/rcmb.2023-0085LE
Weissfuss, C., S.-M. Wienhold, M. Bürkle, B. Gaborieau, J. Bushe, U. Behrendt, R. Bischoff, I. H. E. Korf, S. Wienecke, A. Dannheim, H. Ziehr, C. Rohde, A. D. Gruber, J.-D. Ricard, L. Debarbieux, M. Witzenrath, and G. Nouailles (2023). "Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice." Viruses 15(2): 387. doi.org/10.3390/v15020387.
2022
Bahrs, C., M. Kesselmeier, M. Kolditz, S. Ewig, G. Rohde, G. Barten-Neiner, J. Rupp, M. Witzenrath, T. Welte, and M. W. Pletz (2022). "A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany." European Respiratory Journal 59(2): 2102432. doi.org/10.1183/13993003.02432-2021.
Beuchel, C., J. Dittrich, J. Pott, S. Henger, F. Beutner, B. Isermann, M. Loeffler, J. Thiery, U. Ceglarek, and M. Scholz (2022). "Whole Blood Metabolite Profiles Reflect Changes in Energy Metabolism in Heart Failure." Metabolites 12(3): 216. doi.org/10.3390/metabo12030216.
Dannebaum, R., P. Suwalski, H. Asgharian, G. Du Zhipei, H. Lin, J. Weiner, M. Holtgrewe, C. Thibeault, M. Müller, X. Wang, Z. Karadeniz, J. Saccomanno, J.-M. Doehn, R.-H. Hübner, B. Hinzmann, A. Blüher, S. Siemann, D. Telman, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, W. Poller, L. E. Sander, D. Beule, F. Kurth, T. Guettouche, U. Landmesser, J. Berka, K. Luong, F. Rubelt, and B. Heidecker (2022). "Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19." eClinicalMedicine 48: 101438. doi.org/10.1016/j.eclinm.2022.101438.
Gast, M., V. Nageswaran, A. W. Kuss, A. Tzvetkova, X. Wang, L. H. Mochmann, P. R. Rad, S. Weiss, S. Simm, T. Zeller, H. Voelzke, W. Hoffmann, U. Völker, S. B. Felix, M. Dörr, A. Beling, C. Skurk, D.-M. Leistner, B. H. Rauch, T. Hirose, B. Heidecker, K. Klingel, S. Nakagawa, W. C. Poller, F. K. Swirski, A. Haghikia, and W. Poller (2022). "tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions." Cells 11(24): 3970. doi.org/10.3390/cells11243970.
Graw, J. A., V. Bünger, L. A. Materne, A. Krannich, F. Balzer, R. C. E. Francis, A. Pruß, C. D. Spies, W. M. Kuebler, S. Weber-Carstens, M. Menk, and O. Hunsicker (2022). "Age of Red Cells for Transfusion and Outcomes in Patients with ARDS." J Clin Med 11(1): 245. doi.org/10.3390/jcm11010245.
Hollenhorst, M. I., R. Nandigama, S. B. Evers, I. Gamayun, N. A. Wadood, A. Salah, M. Pieper, A. Wyatt, A. Stukalov, A. Gebhardt, W. Nadolni, W. Burow, C. Herr, C. Beisswenger, S. Kusumakshi, F. Ectors, T. I. Kichko, L. Hübner, P. Reeh, A. Munder, S.-M. Wienhold, M. Witzenrath, R. Bals, V. Flockerzi, T. Gudermann, M. Bischoff, P. Lipp, S. Zierler, V. Chubanov, A. Pichlmair, P. König, U. Boehm, and G. Krasteva-Christ (2022). "Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection." J Clin Invest 132(13). doi.org/10.1172/JCI150951.
Hönzke, K., B. Obermayer, C. Mache, D. Fathykova, M. Kessler, S. Dökel, E. Wyler, M. Baumgardt, A. Löwa, K. Hoffmann, P. Graff, J. Schulze, M. Mieth, K. Hellwig, Z. Demir, B. Biere, L. Brunotte, A. Mecate-Zambrano, J. Bushe, M. Dohmen, C. Hinze, S. Elezkurtaj, M. Tönnies, T. T. Bauer, S. Eggeling, H.-L. Tran, P. Schneider, J. Neudecker, J. C. Rückert, K. M. Schmidt-Ott, J. Busch, F. Klauschen, D. Horst, H. Radbruch, J. Radke, F. Heppner, V. M. Corman, D. Niemeyer, M. A. Müller, C. Goffinet, R. Mothes, A. Pascual-Reguant, A. E. Hauser, D. Beule, M. Landthaler, S. Ludwig, N. Suttorp, M. Witzenrath, A. D. Gruber, C. Drosten, L.-E. Sander, T. Wolff, S. Hippenstiel, and A. C. Hocke (2022). "Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages." European Respiratory Journal. doi.org/10.1183/13993003.02725-2021.
Jiang, T., R. Samapati, S. Klassen, D. Lei, L. Erfinanda, V. Jankowski, S. Simmons, J. Yin, C. Arenz, A. Dietrich, T. Gudermann, D. Adam, M. Schaefer, J. Jankowski, V. Flockerzi, R. Nüsing, S. Uhlig, and W. M. Kuebler (2022). "Stimulation of the EP3 receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells." European Respiratory Journal 60(4). doi.org/10.1183/13993003.02635-2021.
Lask, A., B. Gutbier, O. Kershaw, G. Nouailles, A. D. Gruber, H. C. Müller-Redetzky, S. Chackowicz, D. A. Hamilton, P. Van Slyke, and M. Witzenrath (2022). "Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice." Sci Rep 12(15531): 1–13. doi.org/10.1038/s41598-022-19560-3.
Lingscheid, T., M. Kinzig, A. Krüger, N. Müller, G. Bölke, P. Tober-Lau, F. Münn, H. Kriedemann, M. Witzenrath, L. E. Sander, F. Sörgel, and F. Kurth (2022). "Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis." Antimicrob Agents Chemother. journals.asm.org/doi/10.1128/aac.01229-22.
Lingscheid, T., L. J. Lippert, D. Hillus, T. Kruis, C. Thibeault, E. T. Helbig, P. Tober-Lau, F. Pfäfflin, H. Müller-Redetzky, M. Witzenrath, T. Zoller, A. Uhrig, B. Opitz, N. Suttorp, T. S. Kramer, L. E. Sander, M. S. Stegemann, and F. Kurth (2022). "Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study." Infection. doi.org/10.1007/s15010-022-01796-w.
Matthias Böhme, M., M. Steffen Desch, P. Maciej Rosolowski, P. Markus Scholz, P. Knut Krohn, P. Petra Büttner, P. Michael Cross, P. Janine Kirchberg, M. Karl-Philipp Rommel, M. Janine Pöss, M. Anne Freund, M. Ronny Baber, M. Berend Isermann, P. Uta Ceglarek, M. Klaus H. Metzeler, M. Uwe Platzbecker, and M. Holger Thiele (2022). "Impact of Clonal Hematopoiesis in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction." J Am Coll Cardiol. doi.org/10.1016/j.jacc.2022.08.740.
McVey, M. J., M. Maishan, A. Foley, R. Turki, E. J. Roach, R. Deschler, S. Weidenfeld, N. M. Goldenberg, C. M. Khursigara, and W. M. Kuebler (2022). "Pseudomonas aeruginosa membrane vesicles cause endothelial barrier failure and lung injury." European Respiratory Journal 59(5). doi.org/10.1183/13993003.01500-2021.
Ni, B., S. Chen, K. A. Ryan, M. L. Maitland, J. S. Farrar, M. Witzenrath, B. Gubier, C. Serdjebi, K. Bertotti, R. Wang, F. N. Salloum, L. Marino, B. D. Mitchell, and F. S. Celi (2022). "Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome." Molecular Metabolism: 101588. doi.org/10.1016/j.molmet.2022.101588.
Pennitz, P., H. Kirsten, V. D. Friedrich, E. Wyler, C. Goekeri, B. Obermayer, G. A. Heinz, M.-F. Mashreghi, M. Büttner, J. Trimpert, M. Landthaler, N. Suttorp, A. C. Hocke, S. Hippenstiel, M. Tönnies, M. Scholz, W. M. Kuebler, M. Witzenrath, K. Hoenzke, and G. Nouailles (2022). "A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics." European Respiratory Review 31(165). doi.org/10.1183/16000617.0056-2022.
Peters, L., W. M. Kuebler, and S. Simmons (2022). "Sphingolipids in Atherosclerosis: Chimeras in Structure and Function." Int J Mol Sci 23(19): 11948. doi.org/10.3390/ijms231911948.
Rode, M., K. Nenoff, K. Wirkner, K. Horn, A. Teren, R. Regenthal, M. Loeffler, J. Thiery, A. Aigner, J. Pott, H. Kirsten, and M. Scholz (2022). "Impact of medication on blood transcriptome reveals off-target regulations of beta-blockers." PLOS ONE 17(4): e0266897. doi.org/10.1371/journal.pone.0266897.
Roessler, J., D. M. Leistner, U. Landmesser, and A. Haghikia (2022). "Modulatory role of gut microbiota in cholesterol and glucose metabolism: Potential implications for atherosclerotic cardiovascular disease." Atherosclerosis 359: 1–12. doi.org/10.1016/j.atherosclerosis.2022.08.018.
Schirm, S., A. Haghikia, M. Brack, P. Ahnert, G. Nouailles, N. Suttorp, M. Loeffler, M. Witzenrath, and M. Scholz (2022). "A biomathematical model of atherosclerosis in mice." PLoS One 17(8): e0272079. doi.org/10.1371/journal.pone.0272079.
Scholz, M., K. Horn, J. Pott, A. Gross, M. E. Kleber, G. E. Delgado, P. P. Mishra, H. Kirsten, C. Gieger, M. Muller-Nurasyid, A. Tonjes, P. Kovacs, T. Lehtimaki, O. Raitakari, M. Kahonen, H. Gylling, R. Baber, B. Isermann, M. Stumvoll, M. Loeffler, W. Marz, T. Meitinger, A. Peters, J. Thiery, D. Teupser, and U. Ceglarek (2022). "Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis." Nat Commun 13(1): 143. www.ncbi.nlm.nih.gov/pubmed/35013273.
Sinha, M., D. Zabini, D. Guntur, C. Nagaraj, P. Enyedi, H. Olschewski, W. M. Kuebler, and A. Olschewski (2022). "Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis." Pharmacol Ther 237: 108249. doi.org/10.1016/j.pharmthera.2022.108249.
Steinbeis, F., P. Knape, M. Mittermaier, E. T. Helbig, P. Tober-Lau, C. Thibeault, L. J. Lippert, W. Xiang, M. Müller-Plathe, S. Steinbrecher, H.-J. Meyer, R. M. Ring, C. Ruwwe-Glösenkamp, F. Alius, Y. Li, H. Müller-Redetzky, A. Uhrig, T. Lingscheid, D. Grund, B. Temmesfeld-Wollbrück, N. Suttorp, L. E. Sander, F. Kurth, M. Witzenrath, and T. Zoller (2022). "Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents." Respiratory Medicine: 106968. doi.org/10.1016/j.rmed.2022.106968.
Vlaar, A. P. J., M. Witzenrath, P. van Paassen, L. M. A. Heunks, B. Mourvillier, S. de Bruin, E. H. T. Lim, M. C. Brouwer, P. R. Tuinman, J. F. K. Saraiva, G. Marx, S. M. Lobo, R. Boldo, J. A. Simon-Campos, A. D. Cornet, A. Grebenyuk, J. M. Engelbrecht, M. Mukansi, P. G. Jorens, R. Zerbib, S. Rückinger, K. Pilz, R. Guo, D. van de Beek, N. C. Riedemann, A. P. J. Vlaar, M. Witzenrath, P. van Paassen, L. M. A. Heunks, B. Mourvillier, S. de Bruin, E. H. T. Lim, M. C. Brouwer, P. R. Tuinman, J. F. K. Saraiva, G. Marx, S. Lobo, R. Boldo, J. Simon-Campos, A. D. Cornet, A. Grebenyuk, J. Engelbrecht, M. Mukansi, P. G. Jorens, R. Zerbib, S. Rückinger, K. Pilz, R. Guo, D. van de Beek, N. C. Riedemann, P. Bulpa, F. S. Taccone, G. Hermans, M. Diltoer, M. Piagnerelli, N. De Neve, A. T. Freire, F. D. Pizzol, A. K. Marinho, V. H. Sato, C. Arns da Cunha, M. Neuville, J. Dellamonica, D. Annane, A. Roquilly, J. L. Diehl, F. Schneider, J. P. Mira, J. B. Lascarrou, L. Desmedt, C. Dupuis, C. Schwebel, G. Thiéry, M. Gründling, M. Berger, T. Welte, M. Bauer, U. Jaschinski, K. Matschke, R. Mercado-Longoria, B. Gomez Quintana, J. A. Zamudio-Lerma, J. Moreno Hoyos Abril, A. Aleman Marquez, P. Pickkers, L. Otterspoor, L. Hercilla Vásquez, C. R. Seas Ramos, A. Peña Villalobos, G. Gianella Malca, V. Chávez, V. Filimonov, V. Kulabukhov, P. Acharya, S. A. M. E. G. Timmermans, M. H. Busch, F. L. F. van Baarle, R. Koning, L. ter Horst, N. Chekrouni, T. M. van Soest, M. A. Slim, L. A. van Vught, R. B. E. van Amstel, S. E. Olie, I. E. van Zeggeren, M. C. G. van de Poll, C. Thielert, and D. Neukirchen (2022). "Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial." Lancet Respiratory Medicine. doi.org/10.1016/S2213-2600(22)00297-1.
Voelkel, N. F., H. J. Bogaard, and W. M. Kuebler (2022). "ARDS in the time of corona: context and perspective." American Journal of Physiology-Lung Cellular and Molecular Physiology. journals.physiology.org/doi/full/10.1152/ajplung.00432.2021.
Wyler, E., J. M. Adler, K. Eschke, G. Teixeira Alves, S. Peidli, F. Pott, J. Kazmierski, L. Michalick, O. Kershaw, J. Bushe, S. Andreotti, P. Pennitz, A. Abdelgawad, D. Postmus, C. Goffinet, J. Kreye, S. M. Reincke, H. Prüss, N. Blüthgen, A. D. Gruber, W. M. Kuebler, M. Witzenrath, M. Landthaler, G. Nouailles, and J. Trimpert (2022). "Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics." Mol Ther 30(5): 1952–1965. doi.org/10.1016/j.ymthe.2022.03.014.
2021
Catanese, S., C. F. Beuchel, T. Sawall, F. Lordick, R. Brauer, M. Scholz, U. Ceglarek and U. T. Hacker (2021). "Biomarkers related to fatty acid oxidative capacity are predictive for continued weight loss in cachectic cancer patients." J Cachexia Sarcopenia Muscle. SYMPATH_ doi.org/10.1002/jcsm.12817.
Demichev, V., P. Tober-Lau, O. Lemke, T. Nazarenko, C. Thibeault, H. Whitwell, A. Rohl, A. Freiwald, L. Szyrwiel, D. Ludwig, C. Correia-Melo, S. K. Aulakh, E. T. Helbig, P. Stubbemann, L. J. Lippert, N. M. Gruning, O. Blyuss, S. Vernardis, M. White, C. B. Messner, M. Joannidis, T. Sonnweber, S. J. Klein, A. Pizzini, Y. Wohlfarter, S. Sahanic, R. Hilbe, B. Schaefer, S. Wagner, M. Mittermaier, F. Machleidt, C. Garcia, C. Ruwwe-Glosenkamp, T. Lingscheid, L. Bosquillon de Jarcy, M. S. Stegemann, M. Pfeiffer, L. Jurgens, S. Denker, D. Zickler, P. Enghard, A. Zelezniak, A. Campbell, C. Hayward, D. J. Porteous, R. E. Marioni, A. Uhrig, H. Muller-Redetzky, H. Zoller, J. Loffler-Ragg, M. A. Keller, I. Tancevski, J. F. Timms, A. Zaikin, S. Hippenstiel, M. Ramharter, M. Witzenrath, N. Suttorp, K. Lilley, M. Mulleder, L. E. Sander, P.-C.-S. group, M. Ralser and F. Kurth (2021). "A time-resolved proteomic and prognostic map of COVID-19." Cell Syst 12(8): 780-794 e787. SYMPATH_ & CAPSyS www.ncbi.nlm.nih.gov/pubmed/34139154.
Hadzibegovic, S., A. Lena, T. W. Churchill, J. E. Ho, S. Potthoff, C. Denecke, L. Rösnick, K. M. Heim, M. Kleinschmidt, L. E. Sander, M. Witzenrath, N. Suttorp, A. Krannich, J. Porthun, T. Friede, J. Butler, U. Wilkenshoff, B. Pieske, U. Landmesser, S. D. Anker, G. D. Lewis, C. Tschöpe and M. S. Anker (2021). "Heart Failure with preserved ejection fraction according to the HFA‐PEFF score in COVID‐19 patients: clinical correlates and echocardiographic findings." European Journal of Heart Failure. CAPSyS & SYMPATH_ doi.org/10.1002/ejhf.2210.
Herta, T., A. Bhattacharyya, M. Rosolowski, C. Conrad, C. Gurtner, A. D. Gruber, P. Ahnert, B. Gutbier, D. Frey, N. Suttorp, S. Hippenstiel and J. Zahlten (2021). "Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia." Front Immunol 12: 726135. SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34589087.
Jagdmann, S., D. Berchtold, B. Gutbier, M. Witzenrath, A. Meisel, C. Meisel and C. Dames (2021). "Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections." Journal of Neuroimmunology 355: 577568. CAPSyS & SYMPATH_ doi.org/10.1016/j.jneuroim.2021.577568.
Letsiou, E., L. G. Teixeira Alves, D. Fatykhova, M. Felten, T. J. Mitchell, H. C. Müller-Redetzky, A. C. Hocke and M. Witzenrath (2021). "Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst - Scientific Reports." Sci Rep 11(9529): 1–13. CAPSyS & SYMPATH_ doi.org/10.1038/s41598-021-88897-y.
Letsiou, E., L. G. Teixeira Alves, M. Felten, T. J. Mitchell, H. C. Müller-Redetzky, S. M. Dudek and M. Witzenrath (2021). "Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure." Cells 10(12): 3581. CAPSyS & SYMPATH_ doi.org/10.3390/cells10123581.
Michalick, L., S. Weidenfeld, B. Grimmer, D. Fatykhova, P. D. Solymosi, F. Behrens, M. Dohmen, M. C. Brack, S. Schulz, E. Thomasch, S. Simmons, H. Müller-Redetzky, N. Suttorp, F. Kurth, J. Neudecker, M. Toennies, T. T. Bauer, S. Eggeling, V. M. Corman, A. C. Hocke, M. Witzenrath, S. Hippenstiel and W. M. Kuebler (2021). "Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure." European Respiratory Journal 57(3). CAPSyS & SYMPATH_ doi.org/10.1183/13993003.02384-2020.
Nouailles, G., E. Wyler, P. Pennitz, D. Postmus, D. Vladimirova, J. Kazmierski, F. Pott, K. Dietert, M. Muelleder, V. Farztdinov, B. Obermayer, S.-M. Wienhold, S. Andreotti, T. Hoefler, B. Sawitzki, C. Drosten, L. E. Sander, N. Suttorp, M. Ralser, D. Beule, A. D. Gruber, C. Goffinet, M. Landthaler, J. Trimpert and M. Witzenrath (2021). "Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19." Nat Commun 12. CAPSyS & SYMPATH_ doi.org/10.1038/s41467-021-25030-7.
Ochs, M., S. Timm, S. Elezkurtaj, D. Horst, J. Meinhardt, F. L. Heppner, S. Weber-Carstens, A. C. Hocke and M. Witzenrath (2021). "Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient." European Respiratory Journal 57(5). CAPSyS & SYMPATH_ doi.org/10.1183/13993003.04165-2020.
Pott, J., J. Gadin, E. Theusch, M. E. Kleber, G. E. Delgado, H. Kirsten, S. M. Hauck, R. Burkhardt, H. Scharnagl, R. M. Krauss, M. Loeffler, W. Marz, J. Thiery, A. Silveira, F. M. Vant Hooft and M. Scholz (2021). "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2." Hum Mol Genet. SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34590679.
Pott, J., K. Horn, R. Zeidler, H. Kirsten, P. Ahnert, J. Kratzsch, M. Loeffler, B. Isermann, U. Ceglarek and M. Scholz (2021). "Sex-Specific Causal Relations between Steroid Hormones and Obesity—A Mendelian Randomization Study." Metabolites 11(11): 738. SYMPATH_ doi.org/10.3390/metabo11110738.
Vosa, U., A. Claringbould, H. J. Westra, M. J. Bonder, P. Deelen, B. Zeng, H. Kirsten, A. Saha, R. Kreuzhuber, S. Yazar, H. Brugge, R. Oelen, D. H. de Vries, M. G. P. van der Wijst, S. Kasela, N. Pervjakova, I. Alves, M. J. Fave, M. Agbessi, M. W. Christiansen, R. Jansen, I. Seppala, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, R. Sonmez Flitman, A. Brown, V. Kukushkina, A. Kalnapenkis, S. Rueger, E. Porcu, J. Kronberg, J. Kettunen, B. Lee, F. Zhang, T. Qi, J. A. Hernandez, W. Arindrarto, F. Beutner, B. Consortium, Q. T. L. C. i, J. Dmitrieva, M. Elansary, B. P. Fairfax, M. Georges, B. T. Heijmans, A. W. Hewitt, M. Kahonen, Y. Kim, J. C. Knight, P. Kovacs, K. Krohn, S. Li, M. Loeffler, U. M. Marigorta, H. Mei, Y. Momozawa, M. Muller-Nurasyid, M. Nauck, M. G. Nivard, B. Penninx, J. K. Pritchard, O. T. Raitakari, O. Rotzschke, E. P. Slagboom, C. D. A. Stehouwer, M. Stumvoll, P. Sullivan, P. A. C. t Hoen, J. Thiery, A. Tonjes, J. van Dongen, M. van Iterson, J. H. Veldink, U. Volker, R. Warmerdam, C. Wijmenga, M. Swertz, A. Andiappan, G. W. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. van Meurs, H. Prokisch, H. Ahsan, B. L. Pierce, T. Lehtimaki, D. I. Boomsma, B. M. Psaty, S. A. Gharib, P. Awadalla, L. Milani, W. H. Ouwehand, K. Downes, O. Stegle, A. Battle, P. M. Visscher, J. Yang, M. Scholz, J. Powell, G. Gibson, T. Esko and L. Franke (2021). "Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression." Nat Genet 53(9): 1300-1310. SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34475573.
Weiner, J., P. Suwalski, M. Holtgrewe, A. Rakitko, C. Thibeault, M. Müller, D. Patriki, C. Quedenau, U. Krüger, V. Ilinsky, I. Popov, J. Balnis, A. Jaitovich, E. T. Helbig, L. J. Lippert, P. Stubbemann, L. M. Real, J. Macías, J. A. Pineda, M. Fernandez-Fuertes, X. Wang, Z. Karadeniz, J. Saccomanno, J.-M. Doehn, R.-H. Hübner, B. Hinzmann, M. Salvo, A. Blueher, S. Siemann, S. Jurisic, J. H. Beer, J. Rutishauser, B. Wiggli, H. Schmid, K. Danninger, R. Binder, V. M. Corman, B. Mühlemann, R. Arjun Arkal, G. K. Fragiadakis, E. Mick, C. COMET, C. S. Calfee, D. J. Erle, C. M. Hendrickson, K. N. Kangelaris, M. F. Krummel, P. G. Woodruff, C. R. Langelier, U. Venkataramani, F. García, J. Zyla, C. Drosten, B. Alice, T. C. Jones, N. Suttorp, M. Witzenrath, S. Hippenstiel, T. Zemojtel, C. Skurk, W. Poller, T. Borodina, S. G. Pa-COVID, S. Ripke, L. E. Sander, D. Beule, U. Landmesser, T. Guettouche, F. Kurth and B. Heidecker (2021). "Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01." EClinicalMedicine 40: 101099. CAPSyS & SYMPATH_ doi.org/10.1016/j.eclinm.2021.101099.
Wienhold, S. M., M. C. Brack, G. Nouailles, G. Krishnamoorthy, I. H. E. Korf, C. Seitz, S. Wienecke, K. Dietert, C. Gurtner, O. Kershaw, A. D. Gruber, A. Ross, H. Ziehr, M. Rohde, J. Neudecker, J. Lienau, N. Suttorp, S. Hippenstiel, A. C. Hocke, C. Rohde and M. Witzenrath (2021). "Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection." Viruses 14(1). CAPSyS & SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/35062236.
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2020
Kreye, J., Reincke, S.M., Kornau, H.-C., Sánchez-Sendin, E., Corman, V.M., Liu, H., Yuan, M., Wu, N.C., Zhu, X., Lee, C.-C.D., Trimpert, J., Höltje, M., Dietert, K., Stöffler, L., von Wardenburg, N., van Hoof, S., Homeyer, M.A., Hoffmann, J., Abdelgawad, A., Gruber, A.D., Bertzbach, L.D., Vladimirova, D., Li, L.Y., Barthel, P.C., Skriner, K., Hocke, A.C., Hippenstiel, S., Witzenrath, M., Suttorp, N., Kurth, F., Franke, C., Endres, M., Schmitz, D., Jeworowski, L.M., Richter, A., Schmidt, M.L., Schwarz, T., Müller, M.A., Drosten, C., Wendisch, D., Sander, L.E., Osterrieder, N., Wilson, I.A. and Prüss, H. (2020). "A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model." Cell 183(4): 1058–1069.e1019. doi.org/10.1016/j.cell.2020.09.049.
Messner, C.B., Demichev, V., Wendisch, D., Michalick, L., White, M., Freiwald, A., Textoris-Taube, K., Vernardis, S., Egger, A.-S., Kreidl, M., Ludwig, D., Kilian, C., Agostini, F., Zelezniak, A., Thibeault, C., Pfeiffer, M., Hippenstiel, S., Hocke, A., von Kalle, C., Campbell, A., Hayward, C., Porteous, D.J., Marioni, R.E., Langenberg, C. and Lilley, K.S. (2020). "Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection." Cell Systems 11(1): 11–+. doi.org/10.1016/j.cels.2020.05.012.
Mittermaier, M., Pickerodt, P., Kurth, F., de Jarcy, L.B., Uhrig, A., Garcia, C., Machleidt, F., Pergantis, P., Weber, S., Li, Y., Breitbart, A., Bremer, F., Knape, P., Dewey, M., Doellinger, F., Weber-Carstens, S., Slutsky, A.S., Kuebler, W.M., Suttorp, N. and Müller-Redetzky, H. (2020). "Evaluation of PEEP and prone positioning in early COVID-19 ARDS." EClinicalMedicine 28: 100579. doi.org/10.1016/j.eclinm.2020.100579.
Schirm, S., Ahnert, P., Berger, S., Nouailles, G., Wienhold, S.-M., Müller-Redetzky, H., Suttorp, N., Loeffler, M., Witzenrath, M. and Scholz, M. (2020). "A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection." PLOS ONE 15(12): e0243147. doi.org/10.1371/journal.pone.0243147.