SysMedSUDs

Publications

2023

Domanegg, K., W. H. Sommer, and M. W. Meinhardt (2023). "Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism." Cells 12(6): 963. SysMedSUDs  doi.org/10.3390/cells12060963.

Foo, J. C., I. Skorodumov, R. Spanagel, and M. W. Meinhardt (2023). "Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats." Biol. Sex Differ. 14(1): 1–15. SysMedSUDs & Target-OXY  doi.org/10.1186/s13293-023-00529-4.

Friske, M. M., F. Giannone, M. Senger, R. Seitz, A. C. Hansson, and R. Spanagel (2023). "Chronic alcohol intake regulates expression of SARS-CoV2 infection-relevant genes in an organ-specific manner." Alcohol Clin Exp Res 47(1): 76–86. SysMedSUDs  doi.org/10.1111/acer.14981.

Friske, M. M., and R. Spanagel (2023). "Chronic alcohol consumption and COVID-19 infection risk: A narrative review." Alcohol Clin Exp Res 47(4). SysMedSUDs  doi.org/10.1111/acer.15041.

Li, W., H. Zhou, J. H. Thygesen, M. Heydtmann, I. Smith, F. Degenhardt, M. Nöthen, M. Y. Morgan, H. R. Kranzler, J. Gelernter, N. Bass, and A. McQuillin (2023). "Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders." Psychiatric Genetics 33(6): 233. SysMedAlcoholism & SysMedSUDs  doi.org/10.1097/ypg.0000000000000352.

Patel, K. H., G. B. Walters, H. Stefánsson, K. Stefánsson, F. Degenhardt, M. Nothen, T. Van Der Veen, D. Demontis, A. Borglum, M. Kristiansen, N. J. Bass, and A. McQuillin (2023). "Predicting ADHD in alcohol dependence using polygenic risk scores for ADHD." American Journal of Medical Genetics Part B: Neuropsychiatric Genetics: e32967. SysMedAlcoholism & SysMedSUDs  doi.org/10.1002/ajmg.b.32967.

Poisel, E., L. Zillich, F. Streit, J. Frank, M. M. Friske, J. C. Foo, N. Mechawar, G. Turecki, A. C. Hansson, M. M. Nöthen, M. Rietschel, R. Spanagel, and S. H. Witt (2023). "DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex." Frontiers in Psychiatry 14: 1075250. SysMedSUDs & Target-OXY  doi.org/10.3389/fpsyt.2023.1075250.

Reinwald, J. R., C. N. Schmitz, I. Skorodumov, M. Kuchar, W. Weber-Fahr, R. Spanagel, and M. W. Meinhardt (2023). "Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats." Translational Psychiatry 13(1). SysMedSUDs  doi.org/10.1038/s41398-023-02690-1.

Ruiz-España, S., R. Ortiz-Ramón, Ú. Pérez-Ramírez, A. Díaz-Parra, R. Ciccocioppo, P. Bach, S. Vollstädt-Klein, F. Kiefer, W. H. Sommer, S. Canals, and D. Moratal (2023). "MRI texture-based radiomics analysis for the identification of altered functional networks in alcoholic patients and animal models." Computerized Medical Imaging and Graphics 104: 102187. Target-OXY & SysMedSUDs  doi.org/10.1016/j.compmedimag.2023.102187.

2022

Bilbao, A., and R. Spanagel (2022). "Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications." BMC Med 20(1): 1–29. SysMedSUDs  doi.org/10.1186/s12916-022-02459-1.

Foo, J. C., M. W. Meinhardt, I. Skorodumov, and R. Spanagel (2022). "Alcohol solution strength preference predicts compulsive-like drinking behaviour in rats." Alcohol.: Clin Exp Res n/a(n/a). Target-OXY & SysMedSUDs  doi.org/10.1111/acer.14910.

Knabbe, J., J. Protzmann, N. Schneider, M. Berger, D. Dannehl, S. Wei, C. Strahle, M. Tegtmeier, A. Jaiswal, H. Zheng, M. Krüger, K. Rohr, R. Spanagel, A. Bilbao, M. Engelhardt, H. Scholz, and S. B. Cambridge (2022). "Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain." Proceedings of the National Academy of Sciences 119(25). SysMedSUDs  https://doi.org/10.1073/pnas.2122477119.

Meinhardt, M. W., F. Giannone, N. Hirth, D. Bartsch, S. M. Spampinato, W. Kelsch, R. Spanagel, W. H. Sommer, and A. C. Hansson (2022). "Disrupted circadian expression of β-arrestin 2 affects reward-related µ-opioid receptor function in alcohol dependence." J. Neurochem. 160(4): 454–468. SysMedSUDs  doi.org/10.1111/jnc.15559.

Meinhardt, M. W., and W. H. Sommer (2022). "Schrooms against booze: Potential of mycotherapy for the treatment of AUD." Neuropsychopharmacology: 1–2. SysMedSUDs  doi.org/10.1038/s41386-022-01446-7.

Morella, I., V. Pohořalá, C. Calpe-López, R. Brambilla, R. Spanagel, and R. E. Bernardi (2022). "Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice." Front Pharmacol 0. SysMedSUDs  doi.org/10.3389/fphar.2022.986566.

Tan, H., S. Hubertus, S. Thomas, A. M. Lee, S. Gerhardt, M. F. Gerchen, W. H. Sommer, F. Kiefer, L. Schad, and S. Vollstädt-Klein (2022). "Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder." Psychopharmacology: 1–9. SysMedSUDs  doi.org/10.1007/s00213-022-06301-7.

Vengeliene, V., and R. Spanagel (2022). "mGlu2 mechanism-based interventions to treat alcohol relapse." Front Pharmacol 0. SysMedSUDs  doi.org/10.3389/fphar.2022.985954.

Zillich, L., J. Frank, F. Streit, M. M. Friske, J. C. Foo, L. Sirignano, S. Heilmann-Heimbach, H. Dukal, F. Degenhardt, P. Hoffmann, A. C. Hansson, M. M. Nöthen, M. Rietschel, R. Spanagel, and S. H. Witt (2022). "Epigenome-wide association study of alcohol use disorder in five brain regions." Neuropsychopharmacology 47(4): 832. SysMedSUDs, Target-OXY  doi.org/10.1038/s41386-021-01228-7.

Zillich, L., E. Poisel, J. Frank, J. C. Foo, M. M. Friske, F. Streit, L. Sirignano, S. Heilmann-Heimbach, A. Heimbach, P. Hoffmann, F. Degenhardt, A. C. Hansson, G. Bakalkin, M. M. Nöthen, M. Rietschel, R. Spanagel, and S. H. Witt (2022). "Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum." Translational Psychiatry 12(190): 1–9. SysMedSUDs & Target-OXY  doi.org/10.1038/s41398-022-01959-1.

Zillich, L., E. Poisel, F. Streit, J. Frank, G. R. Fries, J. C. Foo, M. M. Friske, L. Sirignano, A. C. Hansson, M. M. Nöthen, S. H. Witt, C. Walss-Bass, R. Spanagel, and M. Rietschel (2022). "Epigenetic Signatures of Smoking in Five Brain Regions." Journal of Personalized Medicine 12(4): 566. SysMedSUDs & Target-OXY  doi.org/10.3390/jpm12040566.

2021

Biernacka, J. M., B. J. Coombes, A. Batzler, A. M.-C. Ho, J. R. Geske, J. Frank, C. Hodgkinson, M. Skime, C. Colby, L. Zillich, S. Pozsonyiova, M.-F. Ho, F. Kiefer, M. Rietschel, R. Weinshilboum, S. S. O’Malley, K. Mann, R. Anton, D. Goldman and V. M. Karpyak (2021). "Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study." Neuropsychopharmacol 46: 2132–2139. SysMedSUDs doi.org/10.1038/s41386-021-01097-0.

Hansson, A. C. and R. Spanagel (2021). "No changes in the oxytocin system in alcohol-dependent female rodents and humans: Towards a sex-specific psychopharmacology in alcoholism." Addict Biol 26(2). Target-OXY & SysMedSUDs doi.org/10.1111/adb.12945.

Hasanpour, M., E. Mitricheva, N. Logothetis and H. R. Noori (2021). "Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats." Cell Reports 35(2): 108987. NeuroCon & SysMedSUDs doi.org/10.1016/j.celrep.2021.108987.

Li, W., J. H. Thygesen, N. L. O’Brien, M. Heydtmann, I. Smith, F. Degenhardt, M. M. Nöthen, M. Y. Morgan, N. J. Bass and A. McQuillin (2021). "The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses." Psychiatric Genetics 31(1): 13-20. SysMedAlcoholism & SysMedSUDs journals.lww.com/psychgenetics/Fulltext/2021/02000/The_influence_of_regression_models_on_genome_wide.2.aspx.

Meinhardt, M. W., S. Pfarr, G. Fouquet, C. Rohleder, M. L. Meinhardt, J. Barroso-Flores, R. Hoffmann, J. Jeanblanc, E. Paul, K. Wagner, A. C. Hansson, G. Köhr, N. Meier, O. von Bohlen und Halbach, R. L. Bell, H. Endepols, B. Neumaier, K. Schönig, D. Bartsch, M. Naassila, R. Spanagel and W. H. Sommer (2021). "Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism." Sci Adv. SysMedSUDs www.science.org/doi/10.1126/sciadv.abh2399.

Russo, E., T. Ma, R. Spanagel, D. Durstewitz, H. Toutounji and G. Köhr (2021). "Coordinated Prefrontal State Transition Leads Extinction of Reward-Seeking Behaviors." J. Neurosci. 41(11): 2406–2419. SysMedAlcoholism, SysMedSUDs doi.org/10.1523/JNEUROSCI.2588-20.2021.

Scherrer, B., J. Guiraud, G. Addolorato, H. J. Aubin, A. de Bejczy, A. Benyamina, W. van den Brink, F. Caputo, M. Dematteis, A. E. Goudriaan, A. Gual, F. Kiefer, L. Leggio, O. M. Lesch, I. Maremmani, D. J. Nutt, F. Paille, P. Perney, R. Poulnais, Q. Raffaillac, J. Rehm, B. Rolland, N. Simon, B. Soderpalm, W. H. Sommer, H. Walter and R. Spanagel (2021). "Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta-regression analysis to develop an enrichment strategy." Alcohol Clin Exp Res 45(9): 1722-1734. SysMedSUDs www.ncbi.nlm.nih.gov/pubmed/34418121.

Schuster, R., M. Winkler, A. Koopmann, P. Bach, S. Hoffmann, I. Reinhard, R. Spanagel, J. M. Bumb, W. H. Sommer and F. Kiefer (2021). "Calcium Carbonate Attenuates Withdrawal and Reduces Craving: A Randomized Controlled Trial in Alcohol-Dependent Patients." Eur. Addict. Res.: 1–9. SysMEDSUDs doi.org/10.1159/000512763.

Smigielski, L., S. Papiol, A. Theodoridou, K. Heekeren, M. Gerstenberg, D. Wotruba, R. Buechler, P. Hoffmann, S. Herms, K. Adorjan, H. Anderson-Schmidt, M. Budde, A. L. Comes, K. Gade, M. Heilbronner, U. Heilbronner, J. L. Kalman, F. Klöhn-Saghatolislam, D. Reich-Erkelenz, S. K. Schaupp, E. C. Schulte, F. Senner, I.-G. Anghelescu, V. Arolt, B. T. Baune, U. Dannlowski, D. E. Dietrich, A. J. Fallgatter, C. Figge, M. Jäger, G. Juckel, C. Konrad, V. Nieratschker, J. Reimer, E. Reininghaus, M. Schmauß, C. Spitzer, M. von Hagen, J. Wiltfang, J. Zimmermann, A. Gryaznova, L. Flatau-Nagel, M. Reitt, M. Meyers, B. Emons, I. S. Haußleiter, F. U. Lang, T. Becker, M. E. Wigand, S. H. Witt, F. Degenhardt, A. J. Forstner, M. Rietschel, M. M. Nöthen, T. F. M. Andlauer, W. Rössler, S. Walitza, P. Falkai, T. G. Schulze and E. Grünblatt (2021). "Polygenic risk scores across the extended psychosis spectrum." Transl Psychiatry 11(600): 1–11. IntegraMent & SysMedSUDs & Target-OXY doi.org/10.1038/s41398-021-01720-0.

Spanagel, R. and A. Bilbao (2021). "Approved cannabinoids for medical purposes – Comparative systematic review and meta-analysis for sleep and appetite." Neuropharmacology 196: 108680. SysMedSUDs doi.org/10.1016/j.neuropharm.2021.108680.

Surakka, A., V. Vengeliene, I. Skorodumov, M. Meinhardt, A. C. Hansson and R. Spanagel (2021). "Adverse social experiences in adolescent rats result in persistent sex-dependent effects on alcohol-seeking behavior." Alcohol Clin Exp Res 45(7): 1468-1478. SysMedSUDs www.ncbi.nlm.nih.gov/pubmed/34273113.

Velo Escarcena, L., M. Neufeld, M. Rietschel, R. Spanagel and H. Scholz (2021). "ERR and dPECR Suggest a Link Between Neuroprotection and the Regulation of Ethanol Consumption Preference." Frontiers in Psychiatry 12. SysMedAlcoholism & SysMedSUDs www.frontiersin.org/article/10.3389/fpsyt.2021.655816.

Wei, S., S. Hertle, R. Spanagel and A. Bilbao (2021). "NMDA Receptors in Accumbal D1 Neurons Influence Chronic Sugar Consumption and Relapse." eNeuro 8(3). SysMedSUDs doi.org/10.1523/ENEURO.0029-21.2021.

2020

Bilbao, A., D. Neuhofer, M. Sepers, S.-p. Wei, M. Eisenhardt, S. Hertle, O. Lassalle, A. Ramos-Uriarte, N. Puente, R. Lerner, A. Thomazeau, P. Grandes, B. Lutz, O. J. Manzoni and R. Spanagel (2020). "Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior." ISCIENCE 23(3). SysMedAlcoholism & SysMedSUDs doi.org/10.1016/j.isci.2020.100951.

Cannella, N., A. Cosa-Linan, T. Takahashi, W. Weber-Fahr and R. Spanagel (2020). "Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI." Sci Rep 10(19353): 1–14. SysMedSUDs doi.org/10.1038/s41598-020-76182-3.

De Santis, S., A. Cosa-Linan, R. Garcia-Hernandez, L. Dmytrenko, L. Vargova, I. Vorisek, S. Stopponi, P. Bach, P. Kirsch, F. Kiefer, R. Ciccocioppo, E. Sykova, D. Moratal, W. H. Sommer and S. Canals (2020). "Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain." Sci Adv 6(26): eaba0154. Target-OXY, SysMedSUDs doi.org/10.1126/sciadv.aba0154.

Domi, E., L. Xu, M. Paetz, A. Nordeman, G. Augier, L. Holm, S. Toivainen, E. Augier, A. C. Hansson and M. Heilig (2020). "Nicotine increases alcohol self-administration in male rats via a mu-opioid mechanism within the mesolimbic pathway." Br J Pharmacol 177(19): 4516-4531. SysMedSUDs doi.org/10.1111/bph.15210.

Egenrieder, L., E. Mitricheva, R. Spanagel and H. R. Noori (2020). "No basal or drug-induced sex differences in striatal dopaminergic levels: a cluster and meta-analysis of rat microdialysis studies." J Neurochem. SysMedSUDs & NeuroCon doi.org/10.1111/jnc.14911.

Meinhardt, M. W., C. Guengoer, I. Skorodumov, L. J. Mertens and R. Spanagel (2020). "Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse." Neuropsychopharmacology 45(8): 1316-1322. SysMedSUDs doi.org/10.1038/s41386-020-0694-z.

Spanagel, R. (2020). "Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions." Dialogues Clin Neurosci 22(3): 241. SysMedSUDs doi.org/10.31887/DCNS.2020.22.3/rspanagel.

Vengeliene, V., J. C. Foo and J. Kim (2020). "Translational approach to understanding momentary factors associated with alcohol consumption." Br J Pharmacol 177(17): 3878–3897. SysMedSUDs & Target-OXY doi.org/10.1111/bph.15180.

Witt, S. H., J. Frank, U. Frischknecht, J. Treutlein, F. Streit, J. C. Foo, L. Sirignano, H. Dukal, F. Degenhardt, A. Koopmann, S. Hoffmann, G. Koller, O. Pogarell, U. W. Preuss, P. Zill, K. Adorjan, T. G. Schulze, M. Nöthen, R. Spanagel, F. Kiefer and M. Rietschel (2020). "Acute alcohol withdrawal and recovery in men lead to profound changes in DNA methylation profiles – a longitudinal clinical study." Addiction 115(11): 2034-2044. SysMedAlcoholism & SysMedSUDs & IntegraMent doi.org/10.1111/add.15020.

2019

Bernardi, R. F., A. Olevska, I. Morella, S. Fasano, E. Santos, R. Brambilla and R. Spanagel (2019). "The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice." Journal of Neuroscience 39(32): 6325-6338. SysMedSUDs www.ncbi.nlm.nih.gov/pubmed/31182637.

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