Meinhardt, M. W., F. Giannone, N. Hirth, D. Bartsch, S. M. Spampinato, W. Kelsch, R. Spanagel, W. H. Sommer and A. C. Hansson (2022). "Disrupted circadian expression of beta-arrestin 2 affects reward-related micro-opioid receptor function in alcohol dependence." J Neurochem 160(4): 454-468. SysMedSUD

Zillich, L., J. Frank, F. Streit, M. M. Friske, J. C. Foo, L. Sirignano, S. Heilmann-Heimbach, H. Dukal, F. Degenhardt, P. Hoffmann, A. C. Hansson, M. M. Nöthen, M. Rietschel, R. Spanagel and S. H. Witt (2022). "Epigenome-wide association study of alcohol use disorder in five brain regions." Neuropsychopharmacology 47(4): 832. SysMedSUDs, Target-OXY


Biernacka, J. M., B. J. Coombes, A. Batzler, A. M.-C. Ho, J. R. Geske, J. Frank, C. Hodgkinson, M. Skime, C. Colby, L. Zillich, S. Pozsonyiova, M.-F. Ho, F. Kiefer, M. Rietschel, R. Weinshilboum, S. S. O’Malley, K. Mann, R. Anton, D. Goldman and V. M. Karpyak (2021). "Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study." Neuropsychopharmacol 46: 2132–2139. SysMedSUDs

Hansson, A. C. and R. Spanagel (2021). "No changes in the oxytocin system in alcohol-dependent female rodents and humans: Towards a sex-specific psychopharmacology in alcoholism." Addict Biol 26(2). Target-OXY & SysMedSUDs

Hasanpour, M., E. Mitricheva, N. Logothetis and H. R. Noori (2021). "Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats." Cell Reports 35(2): 108987. NeuroCon & SysMedSUDs

Li, W., J. H. Thygesen, N. L. O’Brien, M. Heydtmann, I. Smith, F. Degenhardt, M. M. Nöthen, M. Y. Morgan, N. J. Bass and A. McQuillin (2021). "The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses." Psychiatric Genetics 31(1): 13-20. SysMedAlcoholism & SysMedSUDs

Meinhardt, M. W., S. Pfarr, G. Fouquet, C. Rohleder, M. L. Meinhardt, J. Barroso-Flores, R. Hoffmann, J. Jeanblanc, E. Paul, K. Wagner, A. C. Hansson, G. Köhr, N. Meier, O. von Bohlen und Halbach, R. L. Bell, H. Endepols, B. Neumaier, K. Schönig, D. Bartsch, M. Naassila, R. Spanagel and W. H. Sommer (2021). "Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism." Sci Adv. SysMedSUDs

Russo, E., T. Ma, R. Spanagel, D. Durstewitz, H. Toutounji and G. Köhr (2021). "Coordinated Prefrontal State Transition Leads Extinction of Reward-Seeking Behaviors." J. Neurosci. 41(11): 2406–2419. SysMedAlcoholism, SysMedSUDs

Scherrer, B., J. Guiraud, G. Addolorato, H. J. Aubin, A. de Bejczy, A. Benyamina, W. van den Brink, F. Caputo, M. Dematteis, A. E. Goudriaan, A. Gual, F. Kiefer, L. Leggio, O. M. Lesch, I. Maremmani, D. J. Nutt, F. Paille, P. Perney, R. Poulnais, Q. Raffaillac, J. Rehm, B. Rolland, N. Simon, B. Soderpalm, W. H. Sommer, H. Walter and R. Spanagel (2021). "Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta-regression analysis to develop an enrichment strategy." Alcohol Clin Exp Res 45(9): 1722-1734. SysMedSUDs

Schuster, R., M. Winkler, A. Koopmann, P. Bach, S. Hoffmann, I. Reinhard, R. Spanagel, J. M. Bumb, W. H. Sommer and F. Kiefer (2021). "Calcium Carbonate Attenuates Withdrawal and Reduces Craving: A Randomized Controlled Trial in Alcohol-Dependent Patients." Eur. Addict. Res.: 1–9. SysMEDSUDs

Smigielski, L., S. Papiol, A. Theodoridou, K. Heekeren, M. Gerstenberg, D. Wotruba, R. Buechler, P. Hoffmann, S. Herms, K. Adorjan, H. Anderson-Schmidt, M. Budde, A. L. Comes, K. Gade, M. Heilbronner, U. Heilbronner, J. L. Kalman, F. Klöhn-Saghatolislam, D. Reich-Erkelenz, S. K. Schaupp, E. C. Schulte, F. Senner, I.-G. Anghelescu, V. Arolt, B. T. Baune, U. Dannlowski, D. E. Dietrich, A. J. Fallgatter, C. Figge, M. Jäger, G. Juckel, C. Konrad, V. Nieratschker, J. Reimer, E. Reininghaus, M. Schmauß, C. Spitzer, M. von Hagen, J. Wiltfang, J. Zimmermann, A. Gryaznova, L. Flatau-Nagel, M. Reitt, M. Meyers, B. Emons, I. S. Haußleiter, F. U. Lang, T. Becker, M. E. Wigand, S. H. Witt, F. Degenhardt, A. J. Forstner, M. Rietschel, M. M. Nöthen, T. F. M. Andlauer, W. Rössler, S. Walitza, P. Falkai, T. G. Schulze and E. Grünblatt (2021). "Polygenic risk scores across the extended psychosis spectrum." Transl Psychiatry 11(600): 1–11. IntegraMent & SysMedSUDs & Target-OXY

Spanagel, R. and A. Bilbao (2021). "Approved cannabinoids for medical purposes – Comparative systematic review and meta-analysis for sleep and appetite." Neuropharmacology 196: 108680. SysMedSUDs

Surakka, A., V. Vengeliene, I. Skorodumov, M. Meinhardt, A. C. Hansson and R. Spanagel (2021). "Adverse social experiences in adolescent rats result in persistent sex-dependent effects on alcohol-seeking behavior." Alcohol Clin Exp Res 45(7): 1468-1478. SysMedSUDs

Velo Escarcena, L., M. Neufeld, M. Rietschel, R. Spanagel and H. Scholz (2021). "ERR and dPECR Suggest a Link Between Neuroprotection and the Regulation of Ethanol Consumption Preference." Frontiers in Psychiatry 12. SysMedAlcoholism & SysMedSUDs

Wei, S., S. Hertle, R. Spanagel and A. Bilbao (2021). "NMDA Receptors in Accumbal D1 Neurons Influence Chronic Sugar Consumption and Relapse." eNeuro 8(3). SysMedSUDs


Bilbao, A., D. Neuhofer, M. Sepers, S.-p. Wei, M. Eisenhardt, S. Hertle, O. Lassalle, A. Ramos-Uriarte, N. Puente, R. Lerner, A. Thomazeau, P. Grandes, B. Lutz, O. J. Manzoni and R. Spanagel (2020). "Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior." ISCIENCE 23(3). SysMedAlcoholism & SysMedSUDs

Cannella, N., A. Cosa-Linan, T. Takahashi, W. Weber-Fahr and R. Spanagel (2020). "Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI." Sci Rep 10(19353): 1–14. SysMedSUDs

De Santis, S., A. Cosa-Linan, R. Garcia-Hernandez, L. Dmytrenko, L. Vargova, I. Vorisek, S. Stopponi, P. Bach, P. Kirsch, F. Kiefer, R. Ciccocioppo, E. Sykova, D. Moratal, W. H. Sommer and S. Canals (2020). "Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain." Sci Adv 6(26): eaba0154. Target-OXY, SysMedSUDs

Domi, E., L. Xu, M. Paetz, A. Nordeman, G. Augier, L. Holm, S. Toivainen, E. Augier, A. C. Hansson and M. Heilig (2020). "Nicotine increases alcohol self-administration in male rats via a mu-opioid mechanism within the mesolimbic pathway." Br J Pharmacol 177(19): 4516-4531. SysMedSUDs

Egenrieder, L., E. Mitricheva, R. Spanagel and H. R. Noori (2020). "No basal or drug-induced sex differences in striatal dopaminergic levels: a cluster and meta-analysis of rat microdialysis studies." J Neurochem. SysMedSUDs & NeuroCon

Meinhardt, M. W., C. Guengoer, I. Skorodumov, L. J. Mertens and R. Spanagel (2020). "Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse." Neuropsychopharmacology 45(8): 1316-1322. SysMedSUDs

Spanagel, R. (2020). "Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions." Dialogues Clin Neurosci 22(3): 241. SysMedSUDs

Vengeliene, V., J. C. Foo and J. Kim (2020). "Translational approach to understanding momentary factors associated with alcohol consumption." Br J Pharmacol 177(17): 3878–3897. SysMedSUDs & Target-OXY

Witt, S. H., J. Frank, U. Frischknecht, J. Treutlein, F. Streit, J. C. Foo, L. Sirignano, H. Dukal, F. Degenhardt, A. Koopmann, S. Hoffmann, G. Koller, O. Pogarell, U. W. Preuss, P. Zill, K. Adorjan, T. G. Schulze, M. Nöthen, R. Spanagel, F. Kiefer and M. Rietschel (2020). "Acute alcohol withdrawal and recovery in men lead to profound changes in DNA methylation profiles – a longitudinal clinical study." Addiction 115(11): 2034-2044. SysMedAlcoholism & SysMedSUDs & IntegraMent


Bernardi, R. F., A. Olevska, I. Morella, S. Fasano, E. Santos, R. Brambilla and R. Spanagel (2019). "The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice." Journal of Neuroscience 39(32): 6325-6338. SysMedSUDs

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