CAPSyS

Publikationen

2020

Regier, Y., Komma, K., Weigel, M., Kraiczy, P., Laisi, A., Pulliainen, A. T., Hain, T.Kempf, V. A. J., 2019. Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany. Parasit Vectors, 12(1), 11. doi.org/10.1186/s13071-018-3240-7

Schulte, L. N., Bertrams, W., Stielow, C.Schmeck, B., 2019. ncRNAs in Inflammatory and Infectious Diseases. Methods Mol Biol, 1912, 3-32. doi.org/10.1007/978-1-4939-8982-9_1

2019

Blankenburg, S., Hentschker, C., Nagel, A., Hildebrandt, P., Michalik, S., Dittmar, D., Surmann, K. and Volker, U. (2019). "Improving Proteome Coverage for Small Sample Amounts: An Advanced Method for Proteomics Approaches with Low Bacterial Cell Numbers." Proteomics 19(23): e1900192. www.ncbi.nlm.nih.gov/pubmed/31532911.

Brack, M. C., Lienau, J., Kuebler, W. M. and Witzenrath, M. (2019). "Cardiovascular sequelae of pneumonia." Curr Opin Pulm Med 25(3): 257-262. www.ncbi.nlm.nih.gov/pubmed/30893107.

Dabrowski, A. N., Shrivastav, A., Conrad, C., Komma, K., Weigel, M., Dietert, K., Gruber, A. D., Bertrams, W., Wilhelm, J., Schmeck, B., Reppe, K., N'Guessan, P. D., Aly, S., Suttorp, N., Hain, T. and Zahlten, J. (2019). "Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and Inflammation in Lungs by Control of the Gut Microbiota." Front Immunol 10: 2106. www.ncbi.nlm.nih.gov/pubmed/31616404.

Franssen, F. M., Alter, P., Bar, N., Benedikter, B. J., Iurato, S., Maier, D., Maxheim, M., Roessler, F. K., Spruit, M. A., Vogelmeier, C. F., Wouters, E. F. and Schmeck, B. (2019). "Personalized medicine for patients with COPD: where are we?" Int J Chron Obstruct Pulmon Dis 14: 1465-1484. www.ncbi.nlm.nih.gov/pubmed/31371934.

Jensen, A. V., Baunbaek Egelund, G., Bang Andersen, S., Petersen, P. T., Benfield, T., Witzenrath, M., Rohde, G., Ravn, P., Faurholt-Jepsen, D. and Members of the, C. s. g. e. t. a. (2019). "The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia. A Prospective Cohort Study." Ann Am Thorac Soc 16(12): 1518-1526. www.ncbi.nlm.nih.gov/pubmed/31437014.

Limburg, H., Harbig, A., Bestle, D., Stein, D. A., Moulton, H. M., Jaeger, J., Janga, H., Hardes, K., Koepke, J., Schulte, L., Koczulla, A. R., Schmeck, B., Klenk, H. D. and Bottcher-Friebertshauser, E. (2019). "TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes." J Virol. www.ncbi.nlm.nih.gov/pubmed/31391268.

Lindhauer, N. S., Bertrams, W., Poppel, A., Herkt, C. E., Wesener, A., Hoffmann, K., Greene, B., Van Der Linden, M., Vilcinskas, A., Seidel, K. and Schmeck, B. (2019). "Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae." Virulence 10(1): 902-909. www.ncbi.nlm.nih.gov/pubmed/31657264.

Loeffler-Wirth, H., Kreuz, M., Hopp, L., Arakelyan, A., Haake, A., Cogliatti, S. B., Feller, A. C., Hansmann, M. L., Lenze, D., Moller, P., Muller-Hermelink, H. K., Fortenbacher, E., Willscher, E., Ott, G., Rosenwald, A., Pott, C., Schwaenen, C., Trautmann, H., Wessendorf, S., Stein, H., Szczepanowski, M., Trumper, L., Hummel, M., Klapper, W., Siebert, R., Loeffler, M., Binder, H. and German Cancer Aid consortium Molecular Mechanisms for Malignant, L. (2019). "A modular transcriptome map of mature B cell lymphomas." Genome Med 11(1): 27. www.ncbi.nlm.nih.gov/pubmed/31039827.

Lückel, C., Picard, F., Raifer, H., Carrascosa, L. C., Guralnik, A., Zhang, Y., Klein, M., Bittner, S., Steffen, F., Moos, S., Marini, F., Gloury, R., Kurschus, F. C., Chao, Y.-Y., Bertrams, W., Sexl, V., Schmeck, B., Bonetti, L., Grusdat, M., Lohoff, M., Zielinski, C. E., Zipp, F., Kallies, A., Brenner, D., Berger, M., Bopp, T., Tackenberg, B. and Huber, M. (2019). "IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis." Nat Commun 10(1): 1--15. www.nature.com/articles/s41467-019-13731-z.

Nikoghosyan, M., Hakobyan, S., Hovhannisyan, A., Loeffler-Wirth, H., Binder, H. and Arakelyan, A. (2019). "Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians - A Machine Learning Approach." Front Genet 10: 394. www.ncbi.nlm.nih.gov/pubmed/31105750.

Regier, Y., Komma, K., Weigel, M., Kraiczy, P., Laisi, A., Pulliainen, A. T., Hain, T. and Kempf, V. A. J. (2019). "Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany." Parasites & Vectors 12(1): 11. www.ncbi.nlm.nih.gov/pubmed/30616666.

Scheller, N., Herold, S., Kellner, R., Bertrams, W., Jung, A. L., Janga, H., Greulich, T., Schulte, L. N., Vogelmeier, C. F., Lohmeyer, J. and Schmeck, B. (2019). "Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome." J Infect Dis 219(4): 540-543. www.ncbi.nlm.nih.gov/pubmed/30239899.

Schulte, L. N., Bertrams, W., Stielow, C. and Schmeck, B. (2019). "ncRNAs in Inflammatory and Infectious Diseases." Methods Mol Biol 1912: 3-32. www.ncbi.nlm.nih.gov/pubmed/30635888.

Wienhold, S. M., Lienau, J. and Witzenrath, M. (2019). "Towards Inhaled Phage Therapy in Western Europe." Viruses 11(3). www.ncbi.nlm.nih.gov/pubmed/30909579.

2018

Berger, S., Goekeri, C., Gupta, S. K., Vera, J., Dietert, K., Behrendt, U., Lienau, J., Wienhold, S.-M., Gruber, A. D., Suttorp, N., Witzenrath, M. and Nouailles, G. (2018). "Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia." Critical Care (London, England) 22(1): 287. www.ncbi.nlm.nih.gov/pubmed/30382866.

Dietert, K., Nouailles, G., Gutbier, B., Reppe, K., Berger, S., Jiang, X., Schauer, A. E., Hocke, A. C., Herold, S., Slevogt, H., Witzenrath, M., Suttorp, N. and Gruber, A. D. (2018). "Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia." American Journal of Respiratory Cell and Molecular Biology 58(4): 440-448. www.ncbi.nlm.nih.gov/pubmed/29361238.

Gutbier, B., Neuhauß, A.-K., Reppe, K., Ehrler, C., Santel, A., Kaufmann, J., Scholz, M., Weissmann, N., Morawietz, L., Mitchell, T. J., Aliberti, S., Hippenstiel, S., Suttorp, N., Witzenrath, M., Capnetz and ‡, P. S. G. (2018). "Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia." American Journal of Respiratory and Critical Care Medicine 198(2): 220-231. www.ncbi.nlm.nih.gov/pubmed/29447449.

Gutbier, B., Schönrock, S. M., Ehrler, C., Haberberger, R., Dietert, K., Gruber, A. D., Kummer, W., Michalick, L., Kuebler, W. M., Hocke, A. C., Szymanski, K., Letsiou, E., Lüth, A., Schumacher, F., Kleuser, B., Mitchell, T. J., Bertrams, W., Schmeck, B., Treue, D., Klauschen, F., Bauer, T. T., Tönnies, M., Weissmann, N., Hippenstiel, S., Suttorp, N., Witzenrath, M. and Group, C. S. (2018). "Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2." Critical Care Medicine. www.ncbi.nlm.nih.gov/pubmed/29298188.

Hopp, L., Loeffler-Wirth, H., Nersisyan, L., Arakelyan, A. and Binder, H. (2018). "Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome." Frontiers in Immunology 9: 1620. www.ncbi.nlm.nih.gov/pubmed/30065722.

Kaplonek, P., Khan, N., Reppe, K., Schumann, B., Emmadi, M., Lisboa, M. P., Xu, F.-F., Calow, A. D. J., Parameswarappa, S. G., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2018). "Improving vaccines against Streptococcus pneumoniae using synthetic glycans." Proceedings of the National Academy of Sciences of the United States of America 115(52): 13353-13358. www.ncbi.nlm.nih.gov/pubmed/30530654.

Marin-Sanguino, A., Vera, J. and Alves, R. (2018). "Editorial: Foundations of Theoretical Approaches in Systems Biology." Frontiers in Genetics 9: 290.

Regier, Y., Komma, K., Weigel, M., Pulliainen, A. T., Goettig, S., Hein, T. and Kempf, V. A. J. (2018). "Microbiome Analysis Reveals the Presence of Bartonella spp. and Acinetobacter spp. in Deer Keds (Lipoptena cervi)." Frontiers in Microbiology 9: 3100. www.ncbi.nlm.nih.gov/pubmed/30619179.

Ruiz-Moreno, J. S., Hamann, L., Jin, L., Sander, L. E., Puzianowska-Kuznicka, M., Cambier, J., Witzenrath, M., Schumann, R. R., Suttorp, N. and Opitz, B. (2018). "The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans." Infection and Immunity 86(3). www.ncbi.nlm.nih.gov/pubmed/29263110.

Ruiz-Moreno, J. S., Hamann, L., Shah, J. A., Verbon, A., Mockenhaupt, F. P., Puzianowska-Kuznicka, M., Naujoks, J., Sander, L. E., Witzenrath, M., Cambier, J. C., Suttorp, N., Schumann, R. R., Jin, L., Hawn, T. R., Opitz, B. and Group, C. S. (2018). "The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans." PLoS pathogens 14(1): e1006829. www.ncbi.nlm.nih.gov/pubmed/29298342.

Santos, G., Lai, X., Eberhardt, M. and Vera, J. (2018). "Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling." Frontiers in Cellular and Infection Microbiology 8. www.ncbi.nlm.nih.gov/pubmed/29868515.

Schumann, B., Reppe, K., Kaplonek, P., Wahlbrink, A., Anish, C., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2018). "Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1." ACS central science 4(3): 357-361. www.ncbi.nlm.nih.gov/pubmed/29632881.

Vera, J. and Santos, G. (2018). "Can Gamification Contribute to Computer Modeling-Driven Biomedical Research?" Frontiers in Physiology 9: 908. www.ncbi.nlm.nih.gov/pubmed/30072911.

Wienhold, S.-M., Macrì, M., Nouailles, G., Dietert, K., Gurtner, C., Gruber, A. D., Heimesaat, M. M., Lienau, J., Schumacher, F., Kleuser, B., Opitz, B., Suttorp, N., Witzenrath, M. and Müller-Redetzky, H. C. (2018). "Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice." Critical Care (London, England) 22(1): 282. www.ncbi.nlm.nih.gov/pubmed/30373626.

2017

Arakelyan, A., Nersisyan, L., Poghosyan, D., Khondkaryan, L., Hakobyan, A., Löffler-Wirth, H., Melanitou, E. and Binder, H. (2017). "Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles." PloS One 12(11): e0187572. www.ncbi.nlm.nih.gov/pubmed/29099860.

Cantone, M., Santos, G., Wentker, P., Lai, X. and Vera, J. (2017). "Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection." Frontiers in Physiology 8: 645. www.ncbi.nlm.nih.gov/pubmed/28912729.

Emmadi, M., Khan, N., Lykke, L., Reppe, K., G Parameswarappa, S., Lisboa, M. P., Wienhold, S.-M., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2017). "A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease." Journal of the American Chemical Society 139(41): 14783-14791. www.ncbi.nlm.nih.gov/pubmed/28945368.

Gutbier, B., Jiang, X., Dietert, K., Ehrler, C., Lienau, J., Van Slyke, P., Kim, H., Hoang, V. C., Maynes, J. T., Dumont, D. J., Gruber, A. D., Weissmann, N., Mitchell, T. J., Suttorp, N. and Witzenrath, M. (2017). "Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia." Critical Care (London, England) 21(1): 274. www.ncbi.nlm.nih.gov/pubmed/29132435.

Jensen, A. V., Faurholt-Jepsen, D., Egelund, G. B., Andersen, S. B., Petersen, P. T., Benfield, T., Witzenrath, M., Rohde, G., Ravn, P., German Community-Acquired Pneumonia Competence, N. and German Community-Acquired Pneumonia Competence, N. (2017). "Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study." Clinical Infectious Diseases 65(12): 2091-2098. www.ncbi.nlm.nih.gov/pubmed/29095981.

Jentho, E., Bodden, M., Schulz, C., Jung, A.-L., Seidel, K., Schmeck, B. and Bertrams, W. (2017). "microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1." PloS One 12(4): e0176204. www.ncbi.nlm.nih.gov/pubmed/28445535.

Jung, A. L., Herkt, C. E., Schulz, C., Bolte, K., Seidel, K., Scheller, N., Sittka-Stark, A., Bertrams, W. and Schmeck, B. (2017). "Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles." Scientific Reports 7(1): 6301. www.ncbi.nlm.nih.gov/pubmed/28740179.

Jung, A. L., Hoffmann, K., Herkt, C. E., Schulz, C., Bertrams, W. and Schmeck, B. (2017). "Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages." Journal of Visualized Experiments: JoVE(120). www.ncbi.nlm.nih.gov/pubmed/28287548.

Lisboa, M. P., Khan, N., Martin, C., Xu, F.-F., Reppe, K., Geissner, A., Govindan, S., Witzenrath, M., Pereira, C. L. and Seeberger, P. H. (2017). "Semisynthetic glycoconjugate vaccine candidate againstStreptococcus pneumoniaeserotype 5." Proceedings of the National Academy of Sciences of the United States of America 114(42): 11063-11068. www.ncbi.nlm.nih.gov/pubmed/28973947.

Schulz, C., Lai, X., Bertrams, W., Jung, A. L., Sittka-Stark, A., Herkt, C. E., Janga, H., Zscheppang, K., Stielow, C., Schulte, L., Hippenstiel, S., Vera, J. and Schmeck, B. (2017). "THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study." Scientific Reports 7(1): 11988. www.ncbi.nlm.nih.gov/pubmed/28931863.

Schumann, B., Hahm, H. S., Parameswarappa, S. G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L.-A., Witzenrath, M., Anish, C., Pereira, C. L. and Seeberger, P. H. (2017). "A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine." Science Translational Medicine 9(380). www.ncbi.nlm.nih.gov/pubmed/28275152.

Seeberger, P. H., Pereira, C. L., Khan, N., Xiao, G., Diago-Navarro, E., Reppe, K., Opitz, B., Fries, B. C. and Witzenrath, M. (2017). "A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae." Angewandte Chemie (International Ed. in English) 56(45): 13973-13978. www.ncbi.nlm.nih.gov/pubmed/28815890.

Wentker, P., Eberhardt, M., Dreyer, F. S., Bertrams, W., Cantone, M., Griss, K., Schmeck, B. and Vera, J. (2017). "An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data." Journal of Immunology (Baltimore, Md.: 1950) 198(5): 2191-2201. www.ncbi.nlm.nih.gov/pubmed/28137890.

2016

Arakelyan, A., Nersisyan, L., Petrek, M., Löffler-Wirth, H., Binder, H., 2016. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet 7, 79. doi.org/10.3389/fgene.2016.00079

Du Bois, I., Marsico, A., Bertrams, W., Schweiger, M.R., Caffrey, B.E., Sittka-Stark, A., Eberhardt, M., Vera, J., Vingron, M., Schmeck, B.T., 2016. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J. Infect. Dis. 214, 454–463. doi.org/10.1093/infdis/jiw171

Eberhardt, M., Lai, X., Tomar, N., Gupta, S., Schmeck, B., Steinkasserer, A., Schuler, G., Vera, J., 2016. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol. Biol. 1386, 135–179. doi.org/10.1007/978-1-4939-3283-2_9

Garn, H., Bahn, S., Baune, B.T., Binder, E.B., Bisgaard, H., Chatila, T.A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Müller-Ladner, U., Neurath, M.F., Preissner, K.T., Reinhardt, C., Rook, G., Russell, S., Schmeck, B., Stappenbeck, T., Steinhoff, U., van Os, J., Weiss, S., Zemlin, M., Renz, H., 2016. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J. Allergy Clin. Immunol. 138, 47–56. doi.org/10.1016/j.jaci.2016.02.046

Griss, K., Bertrams, W., Sittka-Stark, A., Seidel, K., Stielow, C., Hippenstiel, S., Suttorp, N., Eberhardt, M., Wilhelm, J., Vera, J., Schmeck, B., 2016. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J. Infect. Dis. 214, 288–299. doi.org/10.1093/infdis/jiw109

Jung, A.L., Stoiber, C., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2016. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 12, e1005592. doi.org/10.1371/journal.ppat.1005592

Kirschner, F., Reppe, K., Andresen, N., Witzenrath, M., Ebstein, F., Kloetzel, P.-M., 2016. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS ONE 11, e0153847. https://doi.org/10.1371/journal.pone.0153847

Lienau, J., Müller-Redetzky, H., Suttorp, N., Witzenrath, M., 2016. [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia]. Pneumologie 70, 372–378. doi.org/10.1055/s-0035-1563788

Lai, X., Wolkenhauer, O., Vera, J., 2016. Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res. 44, 6019–6035. doi.org/10.1093/nar/gkw550

Parameswarappa, S.G., Reppe, K., Geissner, A., Ménová, P., Govindan, S., Calow, A.D.J., Wahlbrink, A., Weishaupt, M.W., Monnanda, B.P., Bell, R.L., Pirofski, L.-A., Suttorp, N., Sander, L.E., Witzenrath, M., Pereira, C.L., Anish, C., Seeberger, P.H., 2016. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection. Cell Chem Biol 23, 1407–1416. doi.org/10.1016/j.chembiol.2016.09.016

Santos, G., Nikolov, S., Lai, X., Eberhardt, M., Dreyer, F.S., Paul, S., Schuler, G., Vera, J., 2016. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis. Sci Rep 6, 24967. doi.org/10.1038/srep24967

Schirm, S., Ahnert, P., Wienhold, S., Mueller-Redetzky, H., Nouailles-Kursar, G., Loeffler, M., Witzenrath, M., Scholz, M., 2016. A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice. PLoS ONE 11, e0156047. doi.org/10.1371/journal.pone.0156047

Schmeck, B., Bertrams, W., Lai, X., Vera, J., 2016. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol. Biol. 1386, 119–133. https://doi.org/10.1007/978-1-4939-3283-2_8

2015

Müller-Redetzky, H., Lienau, J., Suttorp, N., Witzenrath, M., 2015. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev 24, 516–524. doi.org/10.1183/16000617.0034-2015

Reppe, K., Radünzel, P., Dietert, K., Tschernig, T., Wolff, T., Hammerschmidt, S., Gruber, A.D., Suttorp, N., Witzenrath, M., 2015. Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. Infect. Immun. 83, 4617–4629. https://doi.org/10.1128/IAI.00948-15

2014

Witzenrath, M., 2014. Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff! Am. J. Respir. Crit. Care Med. 189, 1452–1455. doi.org/10.1164/rccm.201405-0827ED

 

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