SysINFLAME
Publikationen
2023
Schwarz, A., R. Philippsen, S. G. Piticchio, J. N. Hartmann, R. Häsler, S. Rose-John, and T. Schwarz (2023). "Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model." Front Immunol 14. doi.org/10.3389/fimmu.2023.1038689.
Vaher, H., K. Kingo, P. Kolberg, M. Pook, L. Raam, A. Laanesoo, A. Remm, T. Tenson, K. Alasoo, U. Mrowietz, S. Weidinger, K. Kingo, and A. Rebane (2023). "Skin colonization with S. aureus can lead to increased NLRP1 inflammasome activation in patients with atopic dermatitis." J Invest Dermatol. doi.org/10.1016/j.jid.2023.01.013.
2022
Brandstetter, S., T. Poulain, M. Vogel, C. Meigen, M. Melter, A. Köninger, C. Apfelbacher, W. Kiess, M. Kabesch, A. Körner, and K. K. S. Group (2022). "Families’ Worries during the First and Second COVID-19 Wave in Germany: Longitudinal Study in Two Population-Based Cohorts." Int J Environ Res Public Health 19(5): 2820. doi.org/10.3390/ijerph19052820.
Brunner, J., S. Fill Malfertheiner, S. Brandstetter, B. Seelbach-Göbel, C. Apfelbacher, M. Melter, M. Kabesch, and A. Baessler (2022). "Prevalences of cardiometabolic risk and lifestyle factors in young parents: evidence from a German birth cohort study." BMC Cardiovasc Disord 22(1): 1–10. doi.org/10.1186/s12872-022-02915-z.
Jablonski, K. P., L. Carron, J. Mozziconacci, T. Forne, M. T. Hutt, and A. Lesne (2022). "Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study." Hum Genomics 16(1): 2. www.ncbi.nlm.nih.gov/pubmed/35016721.
Mayer, J., S. Brandstetter, C. Tischer, B. Seelbach-Göbel, S. F. Malfertheiner, M. Melter, M. Kabesch, C. Apfelbacher, P. Arndt, A. Baessler, M. Berneburg, S. Böse- O’Reilly, R. Brunner, W. Buchalla, S. F. Malfertheiner, A. Franke, S. Häusler, I. Heid, C. Herr, W. Högler, S. Kerzel, M. Koller, M. Leitzmann, D. Rothfuß, W. Rösch, B. Schaub, B. H. F. Weber, S. Weidinger, S. Wellmann, and K. K. S. group (2022). "Utilisation of supplementary prenatal screening and diagnostics in Germany: cross-sectional study using data from the KUNO Kids Health Study." BMC Pregnancy and Childbirth 22(1): 436. doi.org/10.1186/s12884-022-04692-1.
Röhrl, D. V., S. Brandstetter, L. P. Siziba, D. Rothenbacher, V. D. Gaertner, S. Harner, A. Köninger, C. Apfelbacher, M. Melter, J. Genuneit, and M. Kabesch (2022). "Food allergy in infants assessed in two German birth cohorts 10 years after the EuroPrevall Study." Pediatr Allergy Immunol 33(1): e13689. doi.org/10.1111/pai.13689.
2021
Brandstetter, S., M. M. Böhmer, M. Pawellek, B. Seelbach-Göbel, M. Melter, M. Kabesch, and C. Apfelbacher (2021). "Parents’ intention to get vaccinated and to have their child vaccinated against COVID-19: cross-sectional analyses using data from the KUNO-Kids health study." Eur J Pediatr 180(11): 3405–3410. doi.org/10.1007/s00431-021-04094-z.
Frede, N., J. Rojas-Restrepo, A. Caballero Garcia de Oteyza, M. Buchta, K. Hübscher, L. Gámez-Díaz, M. Proietti, S. Saghafi, Z. Chavoshzadeh, P. Soler-Palacin, N. Galal, M. Adeli, J. C. Aldave-Becerra, M. S. Al-Ddafari, Ö. Ardenyz, T. P. Atkinson, F. B. Kut, F. Çelmeli, H. Rees, S. S. Kilic, I. Kirovski, C. Klein, R. Kobbe, A.-S. Korganow, D. Lilic, P. Lunt, N. Makwana, A. Metin, T. T. Özgür, A. A. Karakas, S. Seneviratne, R. Sherkat, A. B. Sousa, E. Unal, T. Patiroglu, V. Wahn, H. von Bernuth, M. Whiteford, R. Doffinger, Z. Jouhadi, and B. Grimbacher (2021). "Genetic Analysis of a Cohort of 275 Patients with Hyper-IgE Syndromes and/or Chronic Mucocutaneous Candidiasis." J Clin Immunol 41(8): 1804–1838. doi.org/10.1007/s10875-021-01086-4.
Graus, T. M., S. Brandstetter, B. Seelbach-Göbel, M. Melter, M. Kabesch, C. Apfelbacher, and S. Fill Malfertheiner (2021). "Breastfeeding behavior is not associated with health literacy: evidence from the German KUNO-Kids birth cohort study." Arch Gynecol Obstet 304(5): 1161–1168. doi.org/10.1007/s00404-021-06038-2.
Promm, M., A. Dittrich, S. Brandstetter, S. Fill-Malfertheiner, M. Melter, B. Seelbach-Göbel, C. Apfelbacher, M. Kabesch, W. H. Rösch, and t. K.-K. S. Group (2021). "Evaluation of Undescended Testes in Newborns: It Is Really Simple, Just Not Easy." Urologia Internationalis 105(11-12): 1034–1038. doi.org/10.1159/000517268.
Schreiber, S., K. Aden, J. P. Bernardes, C. Conrad, F. Tran, H. Höper, V. Volk, N. Mishra, J. I. Blase, S. Nikolaus, J. Bethge, T. Kühbacher, C. Röcken, M. Chen, I. Cottingham, N. Petri, B. B. Rasmussen, J. Lokau, L. Lenk, C. Garbers, F. Feuerhake, S. Rose-John, G. H. Waetzig, and P. Rosenstiel (2021). "Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease." Gastroenterology. doi.org/10.1053/j.gastro.2021.02.062.
Torres, G. G., M. Nygaard, A. Caliebe, H. Blanché, S. Chantalat, P. Galan, W. Lieb, L. Christiansen, J.-F. Deleuze, K. Christensen, K. Strauch, M. Müller-Nurasyid, A. Peters, M. M. Nöthen, P. Hoffmann, F. Flachsbart, S. Schreiber, D. Ellinghaus, A. Franke, J. Dose, and A. Nebel (2021). "Exome-wide association study identifies FN3KRP and PGP as new candidate longevity genes." J Gerontol A Biol Sci Med Sci. doi.org/10.1093/gerona/glab023.
2020
Aherrahrou, R., A. E. Kulle, N. Alenina, R. Werner, S. Vens-Cappell, M. Bader, H. Schunkert, J. Erdmann, and Z. Aherrahrou (2020). "CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development." Sci Rep 10(8792): 1–11. doi.org/10.1038/s41598-020-65601-0.
Bertolo, M., S. Baumgart, P. Durek, A. Peddinghaus, H. Mei, T. Rose, P. Enghard, and A. Grützkau (2020). "Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis." Front Immunol 11. doi.org/10.3389/fimmu.2020.00256.
Brandstetter, S., J. Atzendorf, B. Seelbach-Gobel, M. Melter, M. Kabesch, C. Apfelbacher, and K. U.-K. s. group (2020). "Sociodemographic factors associated with health literacy in a large sample of mothers of newborn children: cross-sectional findings from the KUNO-Kids birth cohort study." Eur J Pediatr 179(1): 165-169. www.ncbi.nlm.nih.gov/pubmed/31659468.
Emmert, H., H. Baurecht, F. Thielking, D. Stölzl, E. Rodriguez, I. Harder, E. Proksch, and S. Weidinger (2020). "Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome." Exp Dermatol. doi.org/10.1111/exd.14185.
Gemoll, T., S. Rozanova, C. Röder, S. Hartwig, H. Kalthoff, S. Lehr, A. ElSharawy, and J. K. Habermann (2020). "Protein Profiling of Serum Extracellular Vesicles Reveals Qualitative and Quantitative Differences After Differential Ultracentrifugation and ExoQuickTM Isolation." J Clin Med 9(5): 1429. doi.org/10.3390/jcm9051429.
Hendricks, A., A. Amallraja, T. Meißner, P. Forster, P. Rosenstiel, G. Burmeister, C. Schafmayer, A. Franke, S. Hinz, M. Forster, and C. B. Williams (2020). "Stage IV Colorectal Cancer Patients with High Risk Mutation Profiles Survived 16 Months Longer with Individualized Therapies." Cancers (Basel) 12: 2. www.ncbi.nlm.nih.gov/pubmed/32046290.
Liwinski, T., C. Casar, M. C. Ruehlemann, C. Bang, M. Sebode, S. Hohenester, G. Denk, W. Lieb, A. W. Lohse, A. Franke, and C. Schramm (2020). "A disease-specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis." Aliment Pharmacol Ther n/a(n/a). doi.org/10.1111/apt.15754.
Liwinski, T., R. Zenouzi, C. John, H. Ehlken, M. C. Ruhlemann, C. Bang, S. Groth, W. Lieb, M. Kantowski, N. Andersen, G. Schachschal, T. H. Karlsen, J. R. Hov, T. Rosch, A. W. Lohse, J. Heeren, A. Franke, and C. Schramm (2020). "Alterations of the bile microbiome in primary sclerosing cholangitis." Gut 69(4): 665-672. www.ncbi.nlm.nih.gov/pubmed/31243055.
Lorenzini, T., M. Fliegauf, N. Klammer, N. Frede, M. Proietti, A. Bulashevska, N. Camacho-Ordonez, M. Varjosalo, M. Kinnunen, E. de Vries, J. W. M. van der Meer, R. Ameratunga, C. M. Roifman, Y. D. Schejter, R. Kobbe, T. Hautala, F. Atschekzei, R. E. Schmidt, C. Schröder, P. Stepensky, B. Shadur, L. A. Pedroza, M. van der Flier, M. Martínez-Gallo, L. I. Gonzalez-Granado, L. M. Allende, A. Shcherbina, N. Kuzmenko, V. Zakharova, J. F. Neves, P. Svec, U. Fischer, W. Ip, O. Bartsch, S. Barış, C. Klein, R. Geha, J. Chou, M. Alosaimi, L. Weintraub, K. Boztug, T. Hirschmugl, M. M. Dos Santos Vilela, D. Holzinger, M. Seidl, V. Lougaris, A. Plebani, L. Alsina, M. Piquer-Gibert, A. Deyà-Martínez, C. A. Slade, A. Aghamohammadi, H. Abolhassani, L. Hammarström, O. Kuismin, M. Helminen, H. L. Allen, J. E. Thaventhiran, A. F. Freeman, M. Cook, S. Bakhtiar, M. Christiansen, C. Cunningham-Rundles, N. C. Patel, W. Rae, T. Niehues, N. Brauer, J. Syrjänen, M. R. J. Seppänen, S. O. Burns, P. Tuijnenburg, T. W. Kuijpers, K. Warnatz, B. Grimbacher, Z. Adhya, H. Alachkar, A. Anantharachagan, R. Antrobus, G. Arumugakani, S. Ashford, W. J. Astle, A. Attwood, C. Bacchelli, J. Batista, H. E. Baxendale, C. Bethune, S. Bibi, M. Bleda, B. Boardman, C. Booth, J. R. Bradley, G. Breen, M. Brown, M. J. Browning, M. Brownlie, M. S. Buckland, S. O. Burns, O. S. Burren, K. Carss, J. Chambers, A. Chandra, N. C. Brod, H. Clifford, N. Cooper, L. C. Daugherty, E. G. Davies, S. Davies, J. Davis, S. Deacock, S. V. V. Deevi, J. Dempster, L. A. Devlin, E. F. Dewhurst, K. Downes, E. Drewe, D. Duarte, J. D. M. Edgar, K. Edwards, W. Egner, T. El-Shanawany, M. Erwood, D. Fletcher, J. Fox, A. J. Frary, M. Frontini, A. Furnell, H. B. Gaspar, R. Ghurye, K. C. Gilmour, N. S. Gleadall, S. Goddard, P. Gordins, S. Gräf, L. Grassi, D. Greene, S. Grigoriadou, S. Hackett, R. Hague, M. Haimel, L. Harper, G. Hayman, A. Herwadkar, F. Hu, S. Hughes, A. P. Huissoon, R. James, S. Jolles, J. Jolley, J. Jones, Y. Karim, M. A. Kasanicki, P. Kelleher, C. Kempster, S. Kiani, N. Kingston, N. Klein, M. Kostadima, R. Kreuzhuber, T. W. Kuijpers, D. Kumararatne, J. Laffan, H. L. Allen, S. E. Lear, R. Linger, H. Longhurst, L. E. Lorenzo, P. A. Lyons, J. Maimaris, A. Manson, R. Mapeta, J. Martin, M. I. McCarthy, E. M. McDermott, H. McKinney, S. Meacham, K. Megy, H. Millar, A. Mistry, V. Morrisson, S. H. K. Murng, I. Nasir, S. Nejentsev, S. Noorani, E. Oksenhendler, W. H. Ouwehand, S. Papadia, C. J. Penkett, R. Petersen, M. J. Ponsford, W. Qasim, E. Quinn, I. Quinti, F. L. Raymond, P. J. Rayner-Matthews, A. Richter, N. Samani, C. Samarghitean, A. Sanchis-Juan, R. B. Sargur, S. Savic, S. L. Seneviratne, W. A. C. Sewell, D. Seyres, F. Shackley, O. Shamardina, I. Simeoni, M. A. Simpson, K. G. C. Smith, S. Staines, E. Staples, H. Stark, H. Stauss, C. L. Steele, J. Stephens, K. E. Stirrups, J. E. Thaventhiran, D. Thomas, M. J. Thomas, P. Thomas, A. J. Thrasher, T. Tilly, C. Titterton, P. Treadaway, S. Tuna, E. Turro, R. Urniaz, J. von Ziegenweidt, N. Walker, C. Watt, S. B. Welch, D. Whitehorn, L. Willcocks, N. Wood, Y. Wood, S. Workman, A. Worth, K. Yates, N. Yeatman, P. F. K. Yong, T. Young, P. Yu, and E. Zlamalova (2020). "Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations." Journal of Allergy and Clinical Immunology 146(4): 901–911. doi.org/10.1016/j.jaci.2019.11.051.
Mucha, S., H. Baurecht, N. Novak, E. Rodríguez, S. Bej, G. Mayr, H. Emmert, D. Stölzl, S. Gerdes, E. S. Jung, F. Degenhardt, M. Hübenthal, E. Ellinghaus, J. C. Kässens, L. Wienbrandt, W. Lieb, M. Müller-Nurasyid, M. Hotze, N. Dand, S. Grosche, I. Marenholz, A. Arnold, G. Homuth, C. O. Schmidt, U. Wehkamp, M. M. Nöthen, P. Hoffmann, L. Paternoster, M. Standl, K. Bønnelykke, T. S. Ahluwalia, H. Bisgaard, A. Peters, C. Gieger, M. Waldenberger, H. Schulz, K. Strauch, T. Werfel, Y.-A. Lee, M. Wolfien, P. Rosenstiel, O. Wolkenhauer, S. Schreiber, A. Franke, S. Weidinger, and D. Ellinghaus (2020). "Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression." Journal of Allergy and Clinical Immunology 145(4): 1208–1218. doi.org/10.1016/j.jaci.2019.10.030.
Nyczka, P., and M.-T. Hütt (2020). "Generative network model of transcriptome patterns in disease cohorts with tunable signal strength." Phys Rev Res 2(3): 033130. doi.org/10.1103/PhysRevResearch.2.033130.
Parackova, Z., I. Zentsova, P. Vrabcova, A. Klocperk, Z. Sumnik, S. Pruhova, L. Petruzelkova, R. Hasler, and A. Sediva (2020). "Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes." Front Immunol 11. doi.org/10.3389/fimmu.2020.00661.
Shadrin, A. A., S. Mucha, D. Ellinghaus, M. B. Makarious, C. Blauwendraat, A. A. K. Sreelatha, A. Heras-Garvin, J. Ding, M. Hammer, A. Foubert-Samier, W. G. Meissner, O. Rascol, A. Pavy-Le Traon, O. Frei, K. S. O'Connell, S. Bahrami, S. Schreiber, W. Lieb, M. Muller-Nurasyid, U. Schminke, G. Homuth, C. O. Schmidt, M. M. Nothen, and P. Hoffmann (2020). "Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease." MOVEMENT DISORDERS. doi.org/10.1002/mds.28338.
Thaventhiran, J. E. D., H. Lango Allen, O. S. Burren, W. Rae, D. Greene, E. Staples, Z. Zhang, J. H. R. Farmery, I. Simeoni, E. Rivers, J. Maimaris, C. J. Penkett, J. Stephens, S. V. V. Deevi, A. Sanchis-Juan, N. S. Gleadall, M. J. Thomas, R. B. Sargur, P. Gordins, H. E. Baxendale, M. Brown, P. Tuijnenburg, A. Worth, S. Hanson, R. J. Linger, M. S. Buckland, P. J. Rayner-Matthews, K. C. Gilmour, C. Samarghitean, S. L. Seneviratne, D. M. Sansom, A. G. Lynch, K. Megy, E. Ellinghaus, D. Ellinghaus, S. F. Jorgensen, T. H. Karlsen, K. E. Stirrups, A. J. Cutler, D. S. Kumararatne, A. Chandra, J. D. M. Edgar, A. Herwadkar, N. Cooper, S. Grigoriadou, A. P. Huissoon, S. Goddard, S. Jolles, C. Schuetz, F. Boschann, et al, and P. I. C. f. t. N. Bioresource (2020). "Whole-genome sequencing of a sporadic primary immunodeficiency cohort." Nature 583(7814): 90–95. doi.org/10.1038/s41586-020-2265-1.
Umbach, N., T. Beissbarth, A. Bleckmann, G. Duttge, L. Flatau, A. Konig, J. Kuhn, J. Perera-Bel, J. Roschauer, T. G. Schulze, M. Schweda, A. Urban, A. Zimmermann, and U. Sax (2020). "Clinical application of genomic high-throughput data: Infrastructural, ethical, legal and psychosocial aspects." European Neuropsychopharmacology 31: 1-15. www.ncbi.nlm.nih.gov/pubmed/31866110.
Vaher, H., A. Kivihall, T. Runnel, L. Raam, E. Prans, J. Maslovskaja, K. Abram, B. Kaldvee, U. Mrowietz, S. Weidinger, K. Kingo, and A. Rebane (2020). "SERPINB2 and miR-146a/b are coordinately regulated and act in the suppression of psoriasis-associated inflammatory responses in keratinocytes." Exp Dermatol 29(1): 51-60. www.ncbi.nlm.nih.gov/pubmed/31630447.
Wong, Y. L., L. Hummitzsch, I. Lautenschläger, K. Zitta, T. Wedel, F. Cossais, C. Schafmayer, T. Becker, R. Berndt, M. Gruenewald, N. Weiler, M. Steinfath, and M. Albrecht (2020). "Putative function of goblet cells as epithelial sealing in ischaemia/reperfusion-induced intestinal barrier dysfunction." Gut 69(10): 1888–1890. doi.org/10.1136/gutjnl-2019-319770.
2019
Aden, K., Rehman, A., Waschina, S., Pan, W. H., Walker, A., Lucio, M., Nunez, A. M., Bharti, R., Zimmerman, J., Bethge, J., Schulte, B., Schulte, D., Franke, A., Nikolaus, S., Schroeder, J. O., Vandeputte, D., Raes, J., Szymczak, S., Waetzig, G. H., Zeuner, R., Schmitt-Kopplin, P., Kaleta, C., Schreiber, S. and Rosenstiel, P. (2019). "Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases." Gastroenterology. www.ncbi.nlm.nih.gov/pubmed/31326413.
Brandstetter, S., Toncheva, A. A., Niggel, J., Wolff, C., Gran, S., Seelbach-Göbel, B., Apfelbacher, C., Melter, M., Kabesch, M. and group, K. U.-K. s. (2019). "KUNO-Kids birth cohort study: rationale, design, and cohort description." Molecular and Cellular Pediatrics 6(1): 1. www.ncbi.nlm.nih.gov/pubmed/30627823.
Budzinski, L., Schulz, A. R., Baumgart, S., Burns, T., Rose, T., Hirseland, H. and Mei, H. E. (2019). "Osmium-Labeled Microspheres for Bead-Based Assays in Mass Cytometry." J Immunol. www.ncbi.nlm.nih.gov/pubmed/30988119.
Degenhardt, F., Wendorff, M., Wittig, M., Ellinghaus, E., Datta, L. W., Schembri, J., Ng, S. C., Rosati, E., Hubenthal, M., Ellinghaus, D., Jung, E. S., Lieb, W., Abedian, S., Malekzadeh, R., Cheon, J. H., Ellul, P., Sood, A., Midha, V., Thelma, B. K., Wong, S. H., Schreiber, S., Yamazaki, K., Kubo, M., Boucher, G., Rioux, J. D., Lenz, T. L., Brant, S. R. and Franke, A. (2019). "Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles." Hum Mol Genet 28(12): 2078-2092. www.ncbi.nlm.nih.gov/pubmed/30590525.
Dorjbal, B., Stinson, J. R., Ma, C. A., Weinreich, M. A., Miraghazadeh, B., Hartberger, J. M., Frey-Jakobs, S., Weidinger, S., Moebus, L., Franke, A., Schaffer, A. A., Bulashevska, A., Fuchs, S., Ehl, S., Limaye, S., Arkwright, P. D., Briggs, T. A., Langley, C., Bethune, C., Whyte, A. F., Alachkar, H., Nejentsev, S., DiMaggio, T., Nelson, C. G., Stone, K. D., Nason, M., Brittain, E. H., Oler, A. J., Veltri, D. P., Leahy, T. R., Conlon, N., Poli, M. C., Borzutzky, A., Cohen, J. I., Davis, J., Lambert, M. P., Romberg, N., Sullivan, K. E., Paris, K., Freeman, A. F., Lucas, L., Chandrakasan, S., Savic, S., Hambleton, S., Patel, S. Y., Jordan, M. B., Theos, A., Lebensburger, J., Atkinson, T. P., Torgerson, T. R., Chinn, I. K., Milner, J. D., Grimbacher, B., Cook, M. C. and Snow, A. L. (2019). "Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease." J Allergy Clin Immunol 143(4): 1482-1495. www.ncbi.nlm.nih.gov/pubmed/30170123.
Fazio, A., Bordoni, D. and Rosenstiel, P. (2019). Inflammatory Bowel Disease and Epigenetics. Molecular Genetics of Inflammatory Bowel Diseases, J SpringerLink: 183--201. link.springer.com/chapter/10.1007/978-3-030-28703-0_9.
Flynn, C. M., Garbers, Y., Lokau, J., Wesch, D., Schulte, D. M., Laudes, M., Lieb, W., Aparicio-Siegmund, S. and Garbers, C. (2019). "Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling." Sci Rep 9(1): 7306. www.ncbi.nlm.nih.gov/pubmed/31086276.
Klemann, C., Camacho-Ordonez, N., Yang, L., Eskandarian, Z., Rojas-Restrepo, J. L., Frede, N., Bulashevska, A., Heeg, M., Al-Ddafari, M. S., Premm, J., Seidl, M., Ammann, S., Sherkat, R., Radhakrishnan, N., Warnatz, K., Unger, S., Kobbe, R., Hufner, A., Leahy, T. R., Ip, W., Burns, S. O., Fliegauf, M. and Grimbacher, B. (2019). "Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2." Front Immunol 10: 297. www.ncbi.nlm.nih.gov/pubmed/30941118.
Lipinski, S., Petersen, B. S., Barann, M., Piecyk, A., Tran, F., Mayr, G., Jentzsch, M., Aden, K., Stengel, S. T., Klostermeier, U. C., Sheth, V., Ellinghaus, D., Rausch, T., Korbel, J. O., Nothnagel, M., Krawczak, M., Gilissen, C., Veltman, J. A., Forster, M., Forster, P., Lee, C. C., Fritscher-Ravens, A., Schreiber, S., Franke, A. and Rosenstiel, P. (2019). "Missense variants in NOX1 and p22phox in a case of very-early-onset inflammatory bowel disease are functionally linked to NOD2." Cold Spring Harb Mol Case Stud 5(1). www.ncbi.nlm.nih.gov/pubmed/30709874.
Lipinski, S., Pfeuffer, S., Arnold, P., Treitz, C., Aden, K., Ebsen, H., Falk-Paulsen, M., Gisch, N., Fazio, A., Kuiper, J., Luzius, A., Billmann-Born, S., Schreiber, S., Nunez, G., Beer, H. D., Strowig, T., Lamkanfi, M., Tholey, A. and Rosenstiel, P. (2019). "Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles." EMBO J: e101266. www.ncbi.nlm.nih.gov/pubmed/31544965.
Lopez-Serrano Oliver, A., Haase, A., Peddinghaus, A., Wittke, D., Jakubowski, N., Luch, A., Grutzkau, A. and Baumgart, S. (2019). "Mass Cytometry Enabling Absolute and Fast Quantification of Silver Nanoparticle Uptake at the Single Cell Level." Anal Chem 91(18): 11514-11519. www.ncbi.nlm.nih.gov/pubmed/31429254.
Lougaris, V., Baronio, M., Moratto, D., Tampella, G., Gazzurelli, L., Facchetti, M., Martire, B., Cardinale, F., Lanzarotto, F., Bondioni, M. P., Villanacci, V., Grimbacher, B. and Plebani, A. (2019). "A novel monoallelic gain of function mutation in p110delta causing atypical activated phosphoinositide 3-kinase delta syndrome (APDS-1)." Clin Immunol 200: 31-34. www.ncbi.nlm.nih.gov/pubmed/30639166.
Mitsuiki, N., Schwab, C. and Grimbacher, B. (2019). "What did we learn from CTLA-4 insufficiency on the human immune system?" Immunological Reviews 287(1): 33-49. www.ncbi.nlm.nih.gov/pubmed/30565239.
Ruhlemann, M., Liwinski, T., Heinsen, F. A., Bang, C., Zenouzi, R., Kummen, M., Thingholm, L., Tempel, M., Lieb, W., Karlsen, T., Lohse, A., Hov, J., Denk, G., Lammert, F., Krawczyk, M., Schramm, C. and Franke, A. (2019). "Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis." Aliment Pharmacol Ther 50(5): 580-589. www.ncbi.nlm.nih.gov/pubmed/31250469.
Schlicht, K., Nyczka, P., Caliebe, A., Freitag-Wolf, S., Claringbould, A., Franke, L., Vosa, U., Consortium, B., Kardia, S. L. R., Smith, J. A., Zhao, W., Gieger, C., Peters, A., Prokisch, H., Strauch, K., Group, K. S., Baurecht, H., Weidinger, S., Rosenstiel, P., Hutt, M. T., Knecht, C., Szymczak, S. and Krawczak, M. (2019). "The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus." Hum Genet. www.ncbi.nlm.nih.gov/pubmed/30852652.
Schulz, A. R., Baumgart, S., Schulze, J., Urbicht, M., Grutzkau, A. and Mei, H. E. (2019). "Stabilizing Antibody Cocktails for Mass Cytometry." Cytometry A 95(8): 910-916. www.ncbi.nlm.nih.gov/pubmed/31058420.
Schulz, J., Knappe, C., Graetz, C., Mewes, L., Turk, K., Black, A. K., Lieb, W., Schafer, A. S., Fawzy El-Sayed, K. M., Dorfer, C. E., Schreiber, S., Laudes, M. and Schulte, D. M. (2019). "Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study." J Clin Periodontol 46(5): 522-528. www.ncbi.nlm.nih.gov/pubmed/30762911.
Thingholm, L., Rühlemann, M., Wang, J., Hübenthal, M., Lieb, W., Laudes, M., Franke, A. and D'Amato, M. (2019). "Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition." Gut 68(1): 177-178. www.ncbi.nlm.nih.gov/pubmed/29331942.
Thingholm, L. B., Ruhlemann, M. C., Koch, M., Fuqua, B., Laucke, G., Boehm, R., Bang, C., Franzosa, E. A., Hubenthal, M., Rahnavard, A., Frost, F., Lloyd-Price, J., Schirmer, M., Lusis, A. J., Vulpe, C. D., Lerch, M. M., Homuth, G., Kacprowski, T., Schmidt, C. O., Nothlings, U., Karlsen, T. H., Lieb, W., Laudes, M., Franke, A. and Huttenhower, C. (2019). "Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition." Cell Host Microbe. www.ncbi.nlm.nih.gov/pubmed/31399369.
Vandrovcova, J., Salzer, U., Grimbacher, B., Wanders, J., Rao, K., Thrasher, A., Burns, S., Gilmore, K., Bussel, J. and Cooper, N. (2019). "FAS mutations are an uncommon cause of immune thrombocytopenia in children and adults without additional features of immunodeficiency." Br J Haematol 186(6): e163-e165. www.ncbi.nlm.nih.gov/pubmed/31172514.
Wang, Y., Miller, M., Astrakhan, Y., Petersen, B. S., Schreiber, S., Franke, A. and Bromberg, Y. (2019). "Identifying Crohn's disease signal from variome analysis." Genome Med 11(1): 59. www.ncbi.nlm.nih.gov/pubmed/31564248.
Ziegler, J. F., Bottcher, C., Letizia, M., Yerinde, C., Wu, H., Freise, I., Rodriguez-Sillke, Y., Stoyanova, A. K., Kreis, M. E., Asbach, P., Kunkel, D., Priller, J., Anagnostopoulos, I., Kuhl, A. A., Miehle, K., Stumvoll, M., Tran, F., Fredrich, B., Forster, M., Franke, A., Bojarski, C., Glauben, R., Loscher, B. S., Siegmund, B. and Weidinger, C. (2019). "Leptin induces TNFalpha-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease." Nat Commun 10(1): 5629. www.ncbi.nlm.nih.gov/pubmed/31822667.
2018
Bauer, C., le Saux, O., Pomozi, V., Aherrahrou, R., Kriesen, R., Stölting, S., Liebers, A., Kessler, T., Schunkert, H., Erdmann, J. and Aherrahrou, Z. (2018). "Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation." Scientific Reports 8(1): 5812. www.ncbi.nlm.nih.gov/pubmed/29643466.
Baurecht, H., Rühlemann, M. C., Rodríguez, E., Thielking, F., Harder, I., Erkens, A.-S., Stölzl, D., Ellinghaus, E., Hotze, M., Lieb, W., Wang, S., Heinsen-Groth, F.-A., Franke, A. and Weidinger, S. (2018). "Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration." The Journal of Allergy and Clinical Immunology 141(5): 1668-1676.e1616. www.ncbi.nlm.nih.gov/pubmed/29421277.
Béziat, V., Li, J., Lin, J.-X., Ma, C. S., Li, P., Bousfiha, A., Pellier, I., Zoghi, S., Baris, S., Keles, S., Gray, P., Du, N., Wang, Y., Zerbib, Y., Lévy, R., Leclercq, T., About, F., Lim, A. I., Rao, G., Payne, K., Pelham, S. J., Avery, D. T., Deenick, E. K., Pillay, B., Chou, J., Guery, R., Belkadi, A., Guérin, A., Migaud, M., Rattina, V., Ailal, F., Benhsaien, I., Bouaziz, M., Habib, T., Chaussabel, D., Marr, N., El-Benna, J., Grimbacher, B., Wargon, O., Bustamante, J., Boisson, B., Müller-Fleckenstein, I., Fleckenstein, B., Chandesris, M.-O., Titeux, M., Fraitag, S., Alyanakian, M.-A., Leruez-Ville, M., Picard, C., Meyts, I., Di Santo, J. P., Hovnanian, A., Somer, A., Ozen, A., Rezaei, N., Chatila, T. A., Abel, L., Leonard, W. J., Tangye, S. G., Puel, A. and Casanova, J.-L. (2018). "A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity." Science Immunology 3(24). www.ncbi.nlm.nih.gov/pubmed/29907691.
Egg, D., Schwab, C., Gabrysch, A., Arkwright, P. D., Cheesman, E., Giulino-Roth, L., Neth, O., Snapper, S., Okada, S., Moutschen, M., Delvenne, P., Pecher, A.-C., Wolff, D., Kim, Y.-J., Seneviratne, S., Kim, K.-M., Kang, J.-M., Ojaimi, S., McLean, C., Warnatz, K., Seidl, M. and Grimbacher, B. (2018). "Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers." Frontiers in Immunology 9: 2012. www.ncbi.nlm.nih.gov/pubmed/30250467.
Fangmann, D., Theismann, E.-M., Türk, K., Schulte, D. M., Relling, I., Hartmann, K., Keppler, J. K., Knipp, J.-R., Rehman, A., Heinsen, F.-A., Franke, A., Lenk, L., Freitag-Wolf, S., Appel, E., Gorb, S., Brenner, C., Seegert, D., Waetzig, G. H., Rosenstiel, P., Schreiber, S., Schwarz, K. and Laudes, M. (2018). "Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans." Diabetes Care 41(3): 398-405. www.ncbi.nlm.nih.gov/pubmed/29212824.
Fliegauf, M. and Grimbacher, B. (2018). "Nuclear factor κB mutations in human subjects: The devil is in the details." The Journal of Allergy and Clinical Immunology 142(4): 1062-1065. www.ncbi.nlm.nih.gov/pubmed/30165054.
Forster, M., Mark, A., Egberts, F., Rosati, E., Rodriguez, E., Stanulla, M., Bauerschlag, D., Schem, C., Maass, N., Amallraja, A., Murphy, K. K., Prouse, B. R., Sulaiman, R. A., Young, B. M., Mathiak, M., Hemmrich-Stanisak, G., Ellinghaus, D., Weidinger, S., Rosenstiel, P., Arnold, N., Leyland-Jones, B., Williams, C. B., Franke, A. and Meissner, T. (2018). "RNA based individualized drug selection in breast cancer patients without patient-matched normal tissue." Oncotarget 9(64): 32362-32372. www.ncbi.nlm.nih.gov/pubmed/30190792.
Frey-Jakobs, S., Hartberger, J. M., Fliegauf, M., Bossen, C., Wehmeyer, M. L., Neubauer, J. C., Bulashevska, A., Proietti, M., Fröbel, P., Nöltner, C., Yang, L., Rojas-Restrepo, J., Langer, N., Winzer, S., Engelhardt, K. R., Glocker, C., Pfeifer, D., Klein, A., Schäffer, A. A., Lagovsky, I., Lachover-Roth, I., Béziat, V., Puel, A., Casanova, J.-L., Fleckenstein, B., Weidinger, S., Kilic, S. S., Garty, B.-Z., Etzioni, A. and Grimbacher, B. (2018). "ZNF341 controls STAT3 expression and thereby immunocompetence." Science Immunology 3(24). www.ncbi.nlm.nih.gov/pubmed/29907690.
Gamez-Diaz, L., Sigmund, E. C., Reiser, V., Vach, W., Jung, S. and Grimbacher, B. (2018). "Rapid Flow Cytometry-Based Test for the Diagnosis of Lipopolysaccharide Responsive Beige-Like Anchor (LRBA) Deficiency." Front Immunol 9: 720. www.ncbi.nlm.nih.gov/pubmed/29740429.
Häsler, R., Kautz, C., Rehman, A., Podschun, R., Gassling, V., Brzoska, P., Sherlock, J., Gräsner, J.-T., Hoppenstedt, G., Schubert, S., Ferlinz, A., Lieb, W., Laudes, M., Heinsen, F.-A., Scholz, J., Harmsen, D., Franke, A., Eisend, S., Kunze, T., Fickenscher, H., Ott, S., Rosenstiel, P. and Schreiber, S. (2018). "The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany." Microbiome 6(1): 37. www.ncbi.nlm.nih.gov/pubmed/29458422.
Howell, K. J., Kraiczy, J., Nayak, K. M., Gasparetto, M., Ross, A., Lee, C., Mak, T. N., Koo, B.-K., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O. and Zilbauer, M. (2018). "DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome." Gastroenterology 154(3): 585-598. www.ncbi.nlm.nih.gov/pubmed/29031501.
Jacobs, G., Wolf, A., Krawczak, M. and Lieb, W. (2018). "Biobanks in the Era of Digital Medicine." Clinical Pharmacology and Therapeutics 103(5): 761-762. www.ncbi.nlm.nih.gov/pubmed/29285753.
Jung, S., Gamez-Diaz, L., Proietti, M. and Grimbacher, B. (2018). ""Immune TOR-opathies," a Novel Disease Entity in Clinical Immunology." Frontiers in Immunology 9: 966.
Kachroo, P., Szymczak, S., Heinsen, F.-A., Forster, M., Bethune, J., Hemmrich-Stanisak, G., Baker, L., Schrappe, M., Stanulla, M. and Franke, A. (2018). "NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia." Epigenomics 10(2): 133-147. www.ncbi.nlm.nih.gov/pubmed/29334255.
Nikolaus, S., Waetzig, G. H., Butzin, S., Ziolkiewicz, M., Al-Massad, N., Thieme, F., Lövgren, U., Rasmussen, B. B., Reinheimer, T. M., Seegert, D., Rosenstiel, P., Szymczak, S. and Schreiber, S. (2018). "Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases." International Journal of Colorectal Disease 33(7): 927-936. www.ncbi.nlm.nih.gov/pubmed/29748708.
Oliver, A. L.-S., Baumgart, S., Bremser, W., Flemig, S., Wittke, D., Gruetzkau, A., Luch, A., Haase, A. and Jakubowski, N. (2018). "Quantification of silver nanoparticles taken up by single cells using inductively coupled plasma mass spectrometry in the single cell measurement mode." Journal of Analytical Atomic Spectrometry 33(7): 1256-1263.
Pigors, M., Common, J. E. A., Wong, X. F. C. C., Malik, S., Scott, C. A., Tabarra, N., Liany, H., Liu, J., Limviphuvadh, V., Maurer-Stroh, S., Tang, M. B. Y., Lench, N., Margolis, D. J., van Heel, D. A., Mein, C. A., Novak, N., Baurecht, H., Weidinger, S., McLean, W. H. I., Irvine, A. D., O’Toole, E. A., Simpson, M. A. and Kelsell, D. P. (2018). "Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes." Journal of Investigative Dermatology 138(12): 2674-2677. www.sciencedirect.com/science/article/pii/S0022202X18319900.
Schubert, D., Klein, M.-C., Hassdenteufel, S., Caballero-Oteyza, A., Yang, L., Proietti, M., Bulashevska, A., Kemming, J., Kühn, J., Winzer, S., Rusch, S., Fliegauf, M., Schäffer, A. A., Pfeffer, S., Geiger, R., Cavalié, A., Cao, H., Yang, F., Li, Y., Rizzi, M., Eibel, H., Kobbe, R., Marks, A. L., Peppers, B. P., Hostoffer, R. W., Puck, J. M., Zimmermann, R. and Grimbacher, B. (2018). "Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1)." The Journal of Allergy and Clinical Immunology 141(4): 1427-1438. www.ncbi.nlm.nih.gov/pubmed/28782633.
Schulte, D. M., Paulsen, K., Türk, K., Brandt, B., Freitag-Wolf, S., Hagen, I., Zeuner, R., Schröder, J. O., Lieb, W., Franke, A., Nikolaus, S., Mrowietz, U., Gerdes, S., Schreiber, S. and Laudes, M. (2018). "Small dense LDL cholesterol in human subjects with different chronic inflammatory diseases." Nutrition, metabolism, and cardiovascular diseases: NMCD 28(11): 1100-1105. www.ncbi.nlm.nih.gov/pubmed/30143407.
Schulte-Wrede, U., Sörensen, T., Grün, J. R., Häupl, T., Hirseland, H., Steinbrich-Zöllner, M., Wu, P., Radbruch, A., Poddubnyy, D., Sieper, J., Syrbe, U. and Grützkau, A. (2018). "An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus." Arthritis Research & Therapy 20(1): 191. www.ncbi.nlm.nih.gov/pubmed/30157966.
Schultze, J. L., consortium, S. and Rosenstiel, P. (2018). "Systems Medicine in Chronic Inflammatory Diseases." Immunity 48(4): 608-613. www.ncbi.nlm.nih.gov/pubmed/29669240.
Schwab, C., Gabrysch, A., Olbrich, P., Patiño, V., Warnatz, K., Wolff, D., Hoshino, A., Kobayashi, M., Imai, K., Takagi, M., Dybedal, I., Haddock, J. A., Sansom, D. M., Lucena, J. M., Seidl, M., Schmitt-Graeff, A., Reiser, V., Emmerich, F., Frede, N., Bulashevska, A., Salzer, U., Schubert, D., Hayakawa, S., Okada, S., Kanariou, M., Kucuk, Z. Y., Chapdelaine, H., Petruzelkova, L., Sumnik, Z., Sediva, A., Slatter, M., Arkwright, P. D., Cant, A., Lorenz, H.-M., Giese, T., Lougaris, V., Plebani, A., Price, C., Sullivan, K. E., Moutschen, M., Litzman, J., Freiberger, T., van de Veerdonk, F. L., Recher, M., Albert, M. H., Hauck, F., Seneviratne, S., Pachlopnik Schmid, J., Kolios, A., Unglik, G., Klemann, C., Speckmann, C., Ehl, S., Leichtner, A., Blumberg, R., Franke, A., Snapper, S., Zeissig, S., Cunningham-Rundles, C., Giulino-Roth, L., Elemento, O., Dückers, G., Niehues, T., Fronkova, E., Kanderová, V., Platt, C. D., Chou, J., Chatila, T. A., Geha, R., McDermott, E., Bunn, S., Kurzai, M., Schulz, A., Alsina, L., Casals, F., Deyà-Martinez, A., Hambleton, S., Kanegane, H., Taskén, K., Neth, O. and Grimbacher, B. (2018). "Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects." The Journal of Allergy and Clinical Immunology 142(6): 1932-1946. www.ncbi.nlm.nih.gov/pubmed/29729943.
Worth, L., Michel, S., Gaertner, V. D., Kabesch, M. and Schieck, M. (2018). "Asthma- and IgE-associated polymorphisms affect expression of TH 17 genes." Allergy 73(6): 1342-1347. www.ncbi.nlm.nih.gov/pubmed/29380867.
Zeissig, S., Rosati, E., Dowds, C. M., Aden, K., Bethge, J., Schulte, B., Pan, W. H., Mishra, N., Zuhayra, M., Marx, M., Paulsen, M., Strigli, A., Conrad, C., Schuldt, D., Sinha, A., Ebsen, H., Kornell, S.-C., Nikolaus, S., Arlt, A., Kabelitz, D., Ellrichmann, M., Lützen, U., Rosenstiel, P. C., Franke, A. and Schreiber, S. (2018). "Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease." Gut. www.ncbi.nlm.nih.gov/pubmed/29730603.
Zhu, C., Miller, M., Marpaka, S., Vaysberg, P., Rühlemann, M. C., Wu, G., Heinsen, F.-A., Tempel, M., Zhao, L., Lieb, W., Franke, A. and Bromberg, Y. (2018). "Functional sequencing read annotation for high precision microbiome analysis." Nucleic Acids Research 46(4): e23. www.ncbi.nlm.nih.gov/pubmed/29194524.
2017
Bauer, C. R., Knecht, C., Fretter, C., Baum, B., Jendrossek, S., Rühlemann, M., Heinsen, F.-A., Umbach, N., Grimbacher, B., Franke, A., Lieb, W., Krawczak, M., Hütt, M.-T. and Sax, U. (2017). "Interdisciplinary approach towards a systems medicine toolbox using the example of inflammatory diseases." Briefings in Bioinformatics 18(3): 479-487. www.ncbi.nlm.nih.gov/pubmed/27016392.
Baum, B., Bauer, C., Franke, T., Kusch, H., Parciak, M., Rottmann, T., Umbach, N. and Sax, U. (2017). "Opinion paper: Data provenance challenges in biomedical research." it - Information Technology. www.degruyter.com/view/j/itit.ahead-of-print/itit-2016-0031/itit-2016-0031.xml.
Baumgart, S., Peddinghaus, A., Schulte-Wrede, U., Mei, H. E. and Grützkau, A. (2017). "OMIP-034: Comprehensive immune phenotyping of human peripheral leukocytes by mass cytometry for monitoring immunomodulatory therapies." Cytometry. Part A: The Journal of the International Society for Analytical Cytology 91(1): 34-38. www.ncbi.nlm.nih.gov/pubmed/27362704.
Baumgart, S., Schulz, A. R., Peddinghaus, A., Stanislawiak, S., Gillert, S., Hirseland, H., Krauthäuser, S., Dose, C., Mei, H. E. and Grützkau, A. (2017). "Dual-labelled antibodies for flow and mass cytometry: A new tool for cross-platform comparison and enrichment of target cells for mass cytometry." European Journal of Immunology 47(8): 1377-1385. www.ncbi.nlm.nih.gov/pubmed/28654217.
Brænne, I., Zeng, L., Willenborg, C., Tragante, V., Kessler, T., Consortium, C. A., Consortium, C. A. D., Willer, C. J., Laakso, M., Wallentin, L., Franks, P. W., Salomaa, V., Dehghan, A., Meitinger, T., Samani, N. J., Asselbergs, F. W., Erdmann, J. and Schunkert, H. (2017). "Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk." PloS One 12(8): e0182999. www.ncbi.nlm.nih.gov/pubmed/28829817.
Cavallari, J. F., Fullerton, M. D., Duggan, B. M., Foley, K. P., Denou, E., Smith, B. K., Desjardins, E. M., Henriksbo, B. D., Kim, K. J., Tuinema, B. R., Stearns, J. C., Prescott, D., Rosenstiel, P., Coombes, B. K., Steinberg, G. R. and Schertzer, J. D. (2017). "Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4." Cell Metabolism 25(5): 1063-1074.e1063. www.ncbi.nlm.nih.gov/pubmed/28434881.
Claussen, J. C., Skiecevičienė, J., Wang, J., Rausch, P., Karlsen, T. H., Lieb, W., Baines, J. F., Franke, A. and Hütt, M.-T. (2017). "Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome." PLoS computational biology 13(6): e1005361. www.ncbi.nlm.nih.gov/pubmed/28640804.
Dand, N., Mucha, S., Tsoi, L. C., Mahil, S. K., Stuart, P. E., Arnold, A., Baurecht, H., Burden, A. D., Callis Duffin, K., Chandran, V., Curtis, C. J., Das, S., Ellinghaus, D., Ellinghaus, E., Enerback, C., Esko, T., Gladman, D. D., Griffiths, C. E. M., Gudjonsson, J. E., Hoffman, P., Homuth, G., Hüffmeier, U., Krueger, G. G., Laudes, M., Lee, S. H., Lieb, W., Lim, H. W., Löhr, S., Mrowietz, U., Müller-Nurayid, M., Nöthen, M., Peters, A., Rahman, P., Reis, A., Reynolds, N. J., Rodriguez, E., Schmidt, C. O., Spain, S. L., Strauch, K., Tejasvi, T., Voorhees, J. J., Warren, R. B., Weichenthal, M., Weidinger, S., Zawistowski, M., Nair, R. P., Capon, F., Smith, C. H., Trembath, R. C., Abecasis, G. R., Elder, J. T., Franke, A., Simpson, M. A. and Barker, J. N. (2017). "Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling." Human Molecular Genetics 26(21): 4301-4313. www.ncbi.nlm.nih.gov/pubmed/28973304.
Ellinghaus, E., Ellinghaus, D., Krusche, P., Greiner, A., Schreiber, C., Nikolaus, S., Gieger, C., Strauch, K., Lieb, W., Rosenstiel, P., Frings, N., Fiebig, A., Schreiber, S. and Franke, A. (2017). "Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci." Scientific Reports 7: 45652. www.ncbi.nlm.nih.gov/pubmed/28374850.
Flachsbart, F., Dose, J., Gentschew, L., Geismann, C., Caliebe, A., Knecht, C., Nygaard, M., Badarinarayan, N., ElSharawy, A., May, S., Luzius, A., Torres, G. G., Jentzsch, M., Forster, M., Häesler, R., Pallauf, K., Lieb, W., Derbois, C., Galan, P., Drichel, D., Arlt, A., Till, A., Krause-Kyora, B., Rimbach, G., Blanché, H., Deleuze, J.-F., Christiansen, L., Christensen, K., Nothnagel, M., Rosenstiel, P., Schreiber, S., Franke, A., Sebens, S. and Nebel, A. (2017). "Identification and characterization of two functional variants in the human longevity gene FOXO3." Nature Communications 8(1): 2063. www.ncbi.nlm.nih.gov/pubmed/29234056.
Gámez-Díaz, L., Neumann, J., Jäger, F., Proietti, M., Felber, F., Soulas-Sprauel, P., Perruzza, L., Grassi, F., Kögl, T., Aichele, P., Kilimann, M., Grimbacher, B. and Jung, S. (2017). "Immunological phenotype of the murine Lrba knockout." Immunology and Cell Biology 95(9): 789-802. www.ncbi.nlm.nih.gov/pubmed/28652580.
Guo, Y., Baumgart, S., Stärk, H.-J., Harms, H. and Müller, S. (2017). "Mass Cytometry for Detection of Silver at the Bacterial Single Cell Level." Frontiers in Microbiology 8: 1326. www.ncbi.nlm.nih.gov/pubmed/28769897.
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2015
Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A.D., Kabesch, M., Lee, Y.A.E., Lieb, W., Marenholz, I., McLean, W.H.I., Morris, D.W., Mrowietz, U., Nair, R., Nöthen, M.M., Novak, N., O’Regan, G.M., Psoriasis Association Genetics Extension, Schreiber, S., Smith, C., Strauch, K., Stuart, P.E., Trembath, R., Tsoi, L.C., Weichenthal, M., Barker, J., Elder, J.T., Weidinger, S., Cordell, H.J., Brown, S.J., 2015. Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am. J. Hum. Genet. 96, 104–120. doi.org/10.1016/j.ajhg.2014.12.004
Brænne, I., Civelek, M., Vilne, B., Di Narzo, A., Johnson, A.D., Zhao, Y., Reiz, B., Codoni, V., Webb, T.R., Foroughi Asl, H., Hamby, S.E., Zeng, L., Trégouët, D.-A., Hao, K., Topol, E.J., Schadt, E.E., Yang, X., Samani, N.J., Björkegren, J.L.M., Erdmann, J., Schunkert, H., Lusis, A.J., Leducq Consortium CAD Genomics‡, 2015. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler. Thromb. Vasc. Biol. 35, 2207–2217. doi.org/10.1161/ATVBAHA.115.306108
Buch, S., Stickel, F., Trépo, E., Way, M., Herrmann, A., Nischalke, H.D., Brosch, M., Rosendahl, J., Berg, T., Ridinger, M., Rietschel, M., McQuillin, A., Frank, J., Kiefer, F., Schreiber, S., Lieb, W., Soyka, M., Semmo, N., Aigner, E., Datz, C., Schmelz, R., Brückner, S., Zeissig, S., Stephan, A.-M., Wodarz, N., Devière, J., Clumeck, N., Sarrazin, C., Lammert, F., Gustot, T., Deltenre, P., Völzke, H., Lerch, M.M., Mayerle, J., Eyer, F., Schafmayer, C., Cichon, S., Nöthen, M.M., Nothnagel, M., Ellinghaus, D., Huse, K., Franke, A., Zopf, S., Hellerbrand, C., Moreno, C., Franchimont, D., Morgan, M.Y., Hampe, J., 2015. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat. Genet. 47, 1443–1448. doi.org/10.1038/ng.3417
Fischer, A., Ellinghaus, D., Nutsua, M., Hofmann, S., Montgomery, C.G., Iannuzzi, M.C., Rybicki, B.A., Petrek, M., Mrazek, F., Pabst, S., Grohé, C., Grunewald, J., Ronninger, M., Eklund, A., Padyukov, L., Mihailovic-Vucinic, V., Jovanovic, D., Sterclova, M., Homolka, J., Nöthen, M.M., Herms, S., Gieger, C., Strauch, K., Winkelmann, J., Boehm, B.O., Brand, S., Büning, C., Schürmann, M., Ellinghaus, E., Baurecht, H., Lieb, W., Nebel, A., Müller-Quernheim, J., Franke, A., Schreiber, S., GenPhenReSa Consortium, 2015. Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk. Am. J. Respir. Crit. Care Med. 192, 727–736. doi.org/10.1164/rccm.201503-0418OC
Fliegauf, M., Bryant, V.L., Frede, N., Slade, C., Woon, S.-T., Lehnert, K., Winzer, S., Bulashevska, A., Scerri, T., Leung, E., Jordan, A., Keller, B., de Vries, E., Cao, H., Yang, F., Schäffer, A.A., Warnatz, K., Browett, P., Douglass, J., Ameratunga, R.V., van der Meer, J.W.M., Grimbacher, B., 2015. Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency. Am. J. Hum. Genet. 97, 389–403. doi.org/10.1016/j.ajhg.2015.07.008
Goyette, P., Boucher, G., Mallon, D., Ellinghaus, E., Jostins, L., Huang, H., Ripke, S., Gusareva, E.S., Annese, V., Hauser, S.L., Oksenberg, J.R., Thomsen, I., Leslie, S., International Inflammatory Bowel Disease Genetics Consortium, Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium, Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium, United Kingdom IBDGC, Wellcome Trust Case Control Consortium, Quebec IBD Genetics Consortium, Daly, M.J., Van Steen, K., Duerr, R.H., Barrett, J.C., McGovern, D.P.B., Schumm, L.P., Traherne, J.A., Carrington, M.N., Kosmoliaptsis, V., Karlsen, T.H., Franke, A., Rioux, J.D., 2015. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat. Genet. 47, 172–179. doi.org/10.1038/ng.3176
Koch, M., Baurecht, H., Ried, J.S., Rodriguez, E., Schlesinger, S., Volks, N., Gieger, C., Rückert, I.-M., Heinrich, L., Willenborg, C., Smith, C., Peters, A., Thorand, B., Koenig, W., Lamina, C., Jansen, H., Kronenberg, F., Seissler, J., Thiery, J., Rathmann, W., Schunkert, H., Erdmann, J., Barker, J., Nair, R.P., Tsoi, L.C., Elder, J.T., Mrowietz, U., Weichenthal, M., Mucha, S., Schreiber, S., Franke, A., Schmitt, J., Lieb, W., Weidinger, S., 2015. Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures. J. Invest. Dermatol. 135, 1283–1293. doi.org/10.1038/jid.2015.8
Kunz, M., König, I.R., Schillert, A., Kruppa, J., Ziegler, A., Grallert, H., Müller-Nurasyid, M., Lieb, W., Franke, A., Ranki, A., Panelius, J., Koskenmies, S., Hasan, T., Kere, J., Rönn, A.-C., Simon, J.C., Schmidt, E., Wenzel, J., Tüting, T., Landsberg, J., Zeller, T., Blankenberg, S., Gläser, R., Patsinakidis, N., Kuhn, A., Ibrahim, S.M., 2015. Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus. Exp. Dermatol. 24, 510–515. doi.org/10.1111/exd.12708
Li, J., Jørgensen, S.F., Maggadottir, S.M., Bakay, M., Warnatz, K., Glessner, J., Pandey, R., Salzer, U., Schmidt, R.E., Perez, E., Resnick, E., Goldacker, S., Buchta, M., Witte, T., Padyukov, L., Videm, V., Folseraas, T., Atschekzei, F., Elder, J.T., Nair, R.P., Winkelmann, J., Gieger, C., Nöthen, M.M., Büning, C., Brand, S., Sullivan, K.E., Orange, J.S., Fevang, B., Schreiber, S., Lieb, W., Aukrust, P., Chapel, H., Cunningham-Rundles, C., Franke, A., Karlsen, T.H., Grimbacher, B., Hakonarson, H., Hammarström, L., Ellinghaus, E., 2015. Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nat Commun 6, 6804. doi.org/10.1038/ncomms7804
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Nikpay, M., Goel, A., Won, H.-H., Hall, L.M., Willenborg, C., Kanoni, S., Saleheen, D., Kyriakou, T., Nelson, C.P., Hopewell, J.C., Webb, T.R., Zeng, L., Dehghan, A., Alver, M., Armasu, S.M., Auro, K., Bjonnes, A., Chasman, D.I., Chen, S., Ford, I., Franceschini, N., Gieger, C., Grace, C., Gustafsson, S., Huang, J., Hwang, S.-J., Kim, Y.K., Kleber, M.E., Lau, K.W., Lu, X., Lu, Y., Lyytikäinen, L.-P., Mihailov, E., Morrison, A.C., Pervjakova, N., Qu, L., Rose, L.M., Salfati, E., Saxena, R., Scholz, M., Smith, A.V., Tikkanen, E., Uitterlinden, A., Yang, X., Zhang, W., Zhao, W., de Andrade, M., de Vries, P.S., van Zuydam, N.R., Anand, S.S., Bertram, L., Beutner, F., Dedoussis, G., Frossard, P., Gauguier, D., Goodall, A.H., Gottesman, O., Haber, M., Han, B.-G., Huang, J., Jalilzadeh, S., Kessler, T., König, I.R., Lannfelt, L., Lieb, W., Lind, L., Lindgren, C.M., Lokki, M.-L., Magnusson, P.K., Mallick, N.H., Mehra, N., Meitinger, T., Memon, F.-R., Morris, A.P., Nieminen, M.S., Pedersen, N.L., Peters, A., Rallidis, L.S., Rasheed, A., Samuel, M., Shah, S.H., Sinisalo, J., Stirrups, K.E., Trompet, S., Wang, L., Zaman, K.S., Ardissino, D., Boerwinkle, E., Borecki, I.B., Bottinger, E.P., Buring, J.E., Chambers, J.C., Collins, R., Cupples, L.A., Danesh, J., Demuth, I., Elosua, R., Epstein, S.E., Esko, T., Feitosa, M.F., Franco, O.H., Franzosi, M.G., Granger, C.B., Gu, D., Gudnason, V., Hall, A.S., Hamsten, A., Harris, T.B., Hazen, S.L., Hengstenberg, C., Hofman, A., Ingelsson, E., Iribarren, C., Jukema, J.W., Karhunen, P.J., Kim, B.-J., Kooner, J.S., Kullo, I.J., Lehtimäki, T., Loos, R.J.F., Melander, O., Metspalu, A., März, W., Palmer, C.N., Perola, M., Quertermous, T., Rader, D.J., Ridker, P.M., Ripatti, S., Roberts, R., Salomaa, V., Sanghera, D.K., Schwartz, S.M., Seedorf, U., Stewart, A.F., Stott, D.J., Thiery, J., Zalloua, P.A., O’Donnell, C.J., Reilly, M.P., Assimes, T.L., Thompson, J.R., Erdmann, J., Clarke, R., Watkins, H., Kathiresan, S., McPherson, R., Deloukas, P., Schunkert, H., Samani, N.J., Farrall, M., CARDIoGRAMplusC4D Consortium, 2015. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47, 1121–1130. doi.org/10.1038/ng.3396
Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D.P., Curtin, J.A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A.C., Thyssen, J.P., den Dekker, H.T., Ferreira, M.A., Altmaier, E., Sleiman, P.M.A., Xiao, F.L., Gonzalez, J.R., Marenholz, I., Kalb, B., Pino-Yanes, M., Xu, C.-J., Carstensen, L., Groen-Blokhuis, M.M., Venturini, C., Pennell, C.E., Barton, S.J., Levin, A.M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G.A., Bacelis, J., Bunyavanich, S., Myers, R.A., Matanovic, A., Kumar, A., Tung, J.Y., Hirota, T., Kubo, M., McArdle, W.L., Henderson, A.J., Kemp, J.P., Zheng, J., Smith, G.D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M.A., Arnold, A., Homuth, G., Schmidt, C.O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L.L., Grarup, N., de Jongste, J.C., Rivadeneira, F., Hofman, A., Jaddoe, V.W.V., Pasmans, S.G.M.A., Elbert, N.J., Uitterlinden, A.G., Marks, G.B., Thompson, P.J., Matheson, M.C., Robertson, C.F., Australian Asthma Genetics Consortium (AAGC), Ried, J.S., Li, J., Zuo, X.B., Zheng, X.D., Yin, X.Y., Sun, L.D., McAleer, M.A., O’Regan, G.M., Fahy, C.M.R., Campbell, L.E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D.S., Feenstra, B., Geller, F., Hottenga, J.J., Middeldorp, C.M., Hysi, P., Bataille, V., Spector, T., Tiesler, C.M.T., Thiering, E., Pahukasahasram, B., Yang, J.J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C.L., Myhre, R., Nystad, W., Custovic, A., Weiss, S.T., Meyers, D.A., Söderhäll, C., Melén, E., Ober, C., Raby, B.A., Simpson, A., Jacobsson, B., Holloway, J.W., Bisgaard, H., Sunyer, J., Probst-Hensch, N.M., Williams, L.K., Godfrey, K.M., Wang, C.A., Boomsma, D.I., Melbye, M., Koppelman, G.H., Jarvis, D., McLean, W.H.I., Irvine, A.D., Zhang, X.J., Hakonarson, H., Gieger, C., Burchard, E.G., Martin, N.G., Duijts, L., Linneberg, A., Jarvelin, M.-R., Nöthen, M.M., Lau, S., Hübner, N., Lee, Y.-A., Tamari, M., Hinds, D.A., Glass, D., Brown, S.J., Heinrich, J., Evans, D.M., Weidinger, S., EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, 2015. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat. Genet. 47, 1449–1456. doi.org/10.1038/ng.3424
Schaarschmidt, H., Ellinghaus, D., Rodríguez, E., Kretschmer, A., Baurecht, H., Lipinski, S., Meyer-Hoffert, U., Harder, J., Lieb, W., Novak, N., Fölster-Holst, R., Esparza-Gordillo, J., Marenholz, I., Ruschendorf, F., Hubner, N., Reischl, E., Waldenberger, M., Gieger, C., Illig, T., Kabesch, M., Zhang, X.-J., Xiao, F.-L., Lee, Y.-A., Franke, A., Weidinger, S., 2015. A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis. J. Allergy Clin. Immunol. 136, 802–806. doi.org/10.1016/j.jaci.2015.01.047
Seidel, M.G., Hirschmugl, T., Gamez-Diaz, L., Schwinger, W., Serwas, N., Deutschmann, A., Gorkiewicz, G., Zenz, W., Windpassinger, C., Grimbacher, B., Urban, C., Boztug, K., 2015. Long-term remission after allogeneic hematopoietic stem cell transplantation in LPS-responsive beige-like anchor (LRBA) deficiency. J. Allergy Clin. Immunol. 135, 1384-1390–8. doi.org/10.1016/j.jaci.2014.10.048
Stuart, P.E., Nair, R.P., Tsoi, L.C., Tejasvi, T., Das, S., Kang, H.M., Ellinghaus, E., Chandran, V., Callis-Duffin, K., Ike, R., Li, Y., Wen, X., Enerbäck, C., Gudjonsson, J.E., Kõks, S., Kingo, K., Esko, T., Mrowietz, U., Reis, A., Wichmann, H.E., Gieger, C., Hoffmann, P., Nöthen, M.M., Winkelmann, J., Kunz, M., Moreta, E.G., Mease, P.J., Ritchlin, C.T., Bowcock, A.M., Krueger, G.G., Lim, H.W., Weidinger, S., Weichenthal, M., Voorhees, J.J., Rahman, P., Gregersen, P.K., Franke, A., Gladman, D.D., Abecasis, G.R., Elder, J.T., 2015. Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. Am. J. Hum. Genet. 97, 816–836. doi.org/10.1016/j.ajhg.2015.10.019
Tsoi, L.C., Spain, S.L., Ellinghaus, E., Stuart, P.E., Capon, F., Knight, J., Tejasvi, T., Kang, H.M., Allen, M.H., Lambert, S., Stoll, S.W., Weidinger, S., Gudjonsson, J.E., Koks, S., Kingo, K., Esko, T., Das, S., Metspalu, A., Weichenthal, M., Enerback, C., Krueger, G.G., Voorhees, J.J., Chandran, V., Rosen, C.F., Rahman, P., Gladman, D.D., Reis, A., Nair, R.P., Franke, A., Barker, J.N.W.N., Abecasis, G.R., Trembath, R.C., Elder, J.T., 2015. Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nat Commun 6, 7001. doi.org/10.1038/ncomms8001
Wehr, C., Gennery, A.R., Lindemans, C., Schulz, A., Hoenig, M., Marks, R., Recher, M., Gruhn, B., Holbro, A., Heijnen, I., Meyer, D., Grigoleit, G., Einsele, H., Baumann, U., Witte, T., Sykora, K.-W., Goldacker, S., Regairaz, L., Aksoylar, S., Ardeniz, Ö., Zecca, M., Zdziarski, P., Meyts, I., Matthes-Martin, S., Imai, K., Kamae, C., Fielding, A., Seneviratne, S., Mahlaoui, N., Slatter, M.A., Güngör, T., Arkwright, P.D., van Montfrans, J., Sullivan, K.E., Grimbacher, B., Cant, A., Peter, H.-H., Finke, J., Gaspar, H.B., Warnatz, K., Rizzi, M., Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiency, 2015. Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency. J. Allergy Clin. Immunol. 135, 988–997.e6. doi.org/10.1016/j.jaci.2014.11.029
Yin, X., Low, H.Q., Wang, L., Li, Y., Ellinghaus, E., Han, J., Estivill, X., Sun, L., Zuo, X., Shen, C., Zhu, C., Zhang, A., Sanchez, F., Padyukov, L., Catanese, J.J., Krueger, G.G., Duffin, K.C., Mucha, S., Weichenthal, M., Weidinger, S., Lieb, W., Foo, J.N., Li, Y., Sim, K., Liany, H., Irwan, I., Teo, Y., Theng, C.T.S., Gupta, R., Bowcock, A., De Jager, P.L., Qureshi, A.A., de Bakker, P.I.W., Seielstad, M., Liao, W., Ståhle, M., Franke, A., Zhang, X., Liu, J., 2015. Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun 6, 6916. doi.org/10.1038/ncomms7916
2014
Schubert, D., Bode, C., Kenefeck, R., Hou, T.Z., Wing, J.B., Kennedy, A., Bulashevska, A., Petersen, B.-S., Schäffer, A.A., Grüning, B.A., Unger, S., Frede, N., Baumann, U., Witte, T., Schmidt, R.E., Dueckers, G., Niehues, T., Seneviratne, S., Kanariou, M., Speckmann, C., Ehl, S., Rensing-Ehl, A., Warnatz, K., Rakhmanov, M., Thimme, R., Hasselblatt, P., Emmerich, F., Cathomen, T., Backofen, R., Fisch, P., Seidl, M., May, A., Schmitt-Graeff, A., Ikemizu, S., Salzer, U., Franke, A., Sakaguchi, S., Walker, L.S.K., Sansom, D.M., Grimbacher, B., 2014. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat. Med. 20, 1410–1416. doi.org/10.1038/nm.3746
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