Multiscale HCC



Kuhn Cuellar, L., A. Friedrich, G. Gabernet, L. de la Garza, S. Fillinger, A. Seyboldt, T. Koch, S. Zur Oven-Krockhaus, F. Wanke, S. Richter, W. M. Thaiss, M. Horger, N. Malek, K. Harter, M. Bitzer, and S. Nahnsen (2022). "A data management infrastructure for the integration of imaging and omics data in life sciences." BMC Bioinformatics 23(1): 61.


Ruschil, C., C. L. Kemmerer, L. Beller, G. Gabernet, and M. C. Kowarik (2021). "Next Generation Sequencing of Cerebrospinal Fluid B Cell Repertoires in Multiple Sclerosis and Other Neuro-Inflammatory Diseases—A Comprehensive Review." Diagnostics 11(10): 1871.


Perfahl, H., H. V. Jain, T. Joshi, M. Horger, N. Malek, M. Bitzer, and M. Reuss (2020). "Hybrid Modelling of Transarterial Chemoembolisation Therapies (TACE) for Hepatocellular Carcinoma (HCC)." Sci Rep 10(10571): 1–13.

Ruschil, C., G. Gabernet, G. Lepennetier, S. Heumos, M. Kaminski, Z. Hracsko, M. Irmler, J. Beckers, U. Ziemann, S. Nahnsen, G. P. Owens, J. L. Bennett, B. Hemmer, and M. C. Kowarik (2020). "Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses." Front Immunol 11.

Spahn, S., D. Roessler, R. Pompilia, G. Gabernet, B. P. Gladstone, M. Horger, S. Biskup, M. Feldhahn, S. Nahnsen, F. J. Hilke, B. Scheiner, J.-F. Dufour, E. N. De Toni, M. Pinter, N. P. Malek, and M. Bitzer (2020). "Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma." Cancers 12(12): 3830.

Sueruen, B., C. P. Schaerfe, M. R. Divine, J. Heinrich, N. C. Toussaint, L. Zimmermann, J. Beha, and O. Kohlbacher (2020). "ClinVAP: a reporting strategy from variants to therapeutic options." Bioinformatics (Oxford, England) 36(7): 2316–2317.


Griessinger, C. M., Schmid, A. M., Sonanini, D., Schorg, B. F., Jarboui, M. A., Bukala, D., Mucha, N., Fehrenbacher, B., Steinhilber, J., Martella, M., Kohlhofer, U., Schaller, M., Zender, L., Rammensee, H. G., Quintanilla-Martinez, L., Rocken, M., Kneilling, M. and Pichler, B. J. (2019). "The administration route of tumor-antigen-specific T-helper cells differentially modulates the tumor microenvironment and senescence." Carcinogenesis.

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., Ali, A., Wolf, M. J., Drescher, H., Healy, M. E., Dauch, D., Kroy, D., Krenkel, O., Kohlhepp, M., Engleitner, T., Olkus, A., Sijmonsma, T., Volz, J., Deppermann, C., Stegner, D., Helbling, P., Nombela-Arrieta, C., Rafiei, A., Hinterleitner, M., Rall, M., Baku, F., Borst, O., Wilson, C. L., Leslie, J., O'Connor, T., Weston, C. J., Adams, D. H., Sheriff, L., Teijeiro, A., Prinz, M., Bogeska, R., Anstee, N., Bongers, M. N., Notohamiprodjo, M., Geisler, T., Withers, D. J., Ware, J., Mann, D. A., Augustin, H. G., Vegiopoulos, A., Milsom, M. D., Rose, A. J., Lalor, P. F., Llovet, J. M., Pinyol, R., Tacke, F., Rad, R., Matter, M., Djouder, N., Kubes, P., Knolle, P. A., Unger, K., Zender, L., Nieswandt, B., Gawaz, M., Weber, A. and Heikenwalder, M. (2019). "Platelet GPIbalpha is a mediator and potential interventional target for NASH and subsequent liver cancer." Nat Med 25(4): 641-655.

Thaiss, W. M., Haberland, U., Kaufmann, S., Hepp, T., Schulze, M., Blum, A. C., Ketelsen, D., Nikolaou, K., Horger, M. and Sauter, A. W. (2019). "Dose Optimization of Perfusion-derived Response Assessment in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: Comparison of Volume Perfusion CT and Iodine Concentration." Academic Radiology 26(9): 1154-1163.


Frey, N., Venturelli, S., Zender, L. and Bitzer, M. (2018). "Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics." Nature Reviews. Gastroenterology & Hepatology 15(2): 81-95.

Mohr, C., Friedrich, A., Wojnar, D., Kenar, E., Polatkan, A. C., Codrea, M. C., Czemmel, S., Kohlbacher, O. and Nahnsen, S. (2018). "qPortal: A platform for data-driven biomedical research." PloS One 13(1): e0191603.

Seehawer, M., Heinzmann, F., D'Artista, L., Harbig, J., Roux, P.-F., Hoenicke, L., Dang, H., Klotz, S., Robinson, L., Doré, G., Rozenblum, N., Kang, T.-W., Chawla, R., Buch, T., Vucur, M., Roth, M., Zuber, J., Luedde, T., Sipos, B., Longerich, T., Heikenwälder, M., Wang, X. W., Bischof, O. and Zender, L. (2018). "Necroptosis microenvironment directs lineage commitment in liver cancer." Nature.


Kurucay, M., Kloth, C., Kaufmann, S., Nikolaou, K., Bösmüller, H., Horger, M., Thaiss, W.M., 2017. Multiparametric imaging for detection and characterization of hepatocellular carcinoma using gadoxetic acid-enhanced MRI and perfusion-CT: which parameters work best? Cancer Imaging 17, 18.

Perfahl, H., Hughes, B.D., Alarcón, T., Maini, P.K., Lloyd, M.C., Reuss, M., Byrne, H.M., 2017. 3D hybrid modelling of vascular network formation. Journal of Theoretical Biology 414, 254–268.

Schroeder, C.M., Hilke, F.J., Löffler, M.W., Bitzer, M., Lenz, F., Sturm, M., 2017. A comprehensive quality control workflow for paired tumor-normal NGS experiments. Bioinformatics 33, 1721–1722.


Dauch, D., Rudalska, R., Cossa, G., Nault, J.-C., Kang, T.-W., Wuestefeld, T., Hohmeyer, A., Imbeaud, S., Yevsa, T., Hoenicke, L., Pantsar, T., Bozko, P., Malek, N. P., Longerich, T., Laufer, S., Poso, A., Zucman-Rossi, J., Eilers, M. and Zender, L. (2016). "A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer." Nature Medicine 22(7): 744-753.

Eggert, T., Wolter, K., Ji, J., Ma, C., Yevsa, T., Klotz, S., Medina-Echeverz, J., Longerich, T., Forgues, M., Reisinger, F., Heikenwalder, M., Wang, X. W., Zender, L. and Greten, T. F. (2016). "Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression." Cancer Cell 30(4): 533-547.

Grözinger, G., Bitzer, M., Syha, R., Ketelsen, D., Nikolaou, K., Lauer, U. and Horger, M. (2016). "Correlation of magnetic resonance signal characteristics and perfusion parameters assessed by volume perfusion computed tomography in hepatocellular carcinoma: Impact on lesion characterization." World Journal of Radiology 8(7): 683-692.

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M. P., Matheson, N. J., Patten, D. A., Shetty, S., Parry, A. J., Menon, S., Salama, R., Antrobus, R., Tomimatsu, K., Howat, W., Lehner, P. J., Zender, L. and Narita, M. (2016). "NOTCH1 mediates a switch between two distinct secretomes during senescence." Nature Cell Biology 18(9): 979-992.

Syha, R., Grözinger, G., Grosse, U., Maurer, M., Zender, L., Horger, M., Nikolaou, K. and Ketelsen, D. (2016). "Parenchymal Blood Volume Assessed by C-Arm-Based Computed Tomography in Immediate Posttreatment Evaluation of Drug-Eluting Bead Transarterial Chemoembolization in Hepatocellular Carcinoma." Investigative Radiology 51(2): 121-126.

Thaiss, W. M., Kaufmann, S., Kloth, C., Nikolaou, K., Bösmüller, H. and Horger, M. (2016). "VEGFR-2 expression in HCC, dysplastic and regenerative liver nodules, and correlation with pre-biopsy Dynamic Contrast Enhanced CT." European Journal of Radiology 85(11): 2036-2041.


Kaufmann, S., Horger, T., Oelker, A., Beck, S., Schulze, M., Nikolaou, K., Ketelsen, D., Horger, M., 2015a. Volume perfusion computed tomography (VPCT)-based evaluation of response to TACE using two different sized drug eluting beads in patients with nonresectable hepatocellular carcinoma: Impact on tumor and liver parenchymal vascularisation. Eur J Radiol 84, 2548–2554.

Kaufmann, S., Horger, T., Oelker, A., Kloth, C., Nikolaou, K., Schulze, M., Horger, M., 2015b. Characterization of hepatocellular carcinoma (HCC) lesions using a novel CT-based volume perfusion (VPCT) technique. Eur J Radiol 84, 1029–1035.

Schneeweiß, S., Horger, M., Ketelsen, D., Ioanoviciu, S.D., 2015. [Complications after TACE in HCC]. Rofo 36, 79–82.


Dengel, B.-S., Perfahl, H., Galliani, S., Reuss, M., 2015. The VasCan Project: Simulation of Vascular Tumour Growth and Angiogenesis Using a Multiscale Model, in: High Performance Computing in Science and Engineering ‘14. Springer, Cham, pp. 683–691.


Multiscale HCC-Projekte in den Medien:

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