SYMPATH

Bahrs, C., M. Kesselmeier, M. Kolditz, S. Ewig, G. Rohde, G. Barten-Neiner, J. Rupp, M. Witzenrath, T. Welte and M. W. Pletz (2022). "A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany." European Respiratory Journal 59(2): 2102432. CAPSyS & SYMPATH_ doi.org/10.1183/13993003.02432-2021.

Beuchel, C., J. Dittrich, J. Pott, S. Henger, F. Beutner, B. Isermann, M. Loeffler, J. Thiery, U. Ceglarek and M. Scholz (2022). "Whole Blood Metabolite Profiles Reflect Changes in Energy Metabolism in Heart Failure." Metabolites 12(3): 216. SYMPATH_ doi.org/10.3390/metabo12030216.

Dannebaum, R., P. Suwalski, H. Asgharian, G. Du Zhipei, H. Lin, J. Weiner, M. Holtgrewe, C. Thibeault, M. Müller, X. Wang, Z. Karadeniz, J. Saccomanno, J.-M. Doehn, R.-H. Hübner, B. Hinzmann, A. Blüher, S. Siemann, D. Telman, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, W. Poller, L. E. Sander, D. Beule, F. Kurth, T. Guettouche, U. Landmesser, J. Berka, K. Luong, F. Rubelt and B. Heidecker (2022). "Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19." eClinicalMedicine 48: 101438. CAPSyS & SYMPATH_ doi.org/10.1016/j.eclinm.2022.101438.

Graw, J. A., V. Bünger, L. A. Materne, A. Krannich, F. Balzer, R. C. E. Francis, A. Pruß, C. D. Spies, W. M. Kuebler, S. Weber-Carstens, M. Menk and O. Hunsicker (2022). "Age of Red Cells for Transfusion and Outcomes in Patients with ARDS." J Clin Med 11(1): 245. SYMPATH_ doi.org/10.3390/jcm11010245.

Hollenhorst, M. I., R. Nandigama, S. B. Evers, I. Gamayun, N. A. Wadood, A. Salah, M. Pieper, A. Wyatt, A. Stukalov, A. Gebhardt, W. Nadolni, W. Burow, C. Herr, C. Beisswenger, S. Kusumakshi, F. Ectors, T. I. Kichko, L. Hübner, P. Reeh, A. Munder, S.-M. Wienhold, M. Witzenrath, R. Bals, V. Flockerzi, T. Gudermann, M. Bischoff, P. Lipp, S. Zierler, V. Chubanov, A. Pichlmair, P. König, U. Boehm and G. Krasteva-Christ (2022). "Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection." J Clin Invest 132(13). CAPSyS & SYMPATH_ doi.org/10.1172/JCI150951.

Hönzke, K., B. Obermayer, C. Mache, D. Fathykova, M. Kessler, S. Dökel, E. Wyler, M. Baumgardt, A. Löwa, K. Hoffmann, P. Graff, J. Schulze, M. Mieth, K. Hellwig, Z. Demir, B. Biere, L. Brunotte, A. Mecate-Zambrano, J. Bushe, M. Dohmen, C. Hinze, S. Elezkurtaj, M. Tönnies, T. T. Bauer, S. Eggeling, H.-L. Tran, P. Schneider, J. Neudecker, J. C. Rückert, K. M. Schmidt-Ott, J. Busch, F. Klauschen, D. Horst, H. Radbruch, J. Radke, F. Heppner, V. M. Corman, D. Niemeyer, M. A. Müller, C. Goffinet, R. Mothes, A. Pascual-Reguant, A. E. Hauser, D. Beule, M. Landthaler, S. Ludwig, N. Suttorp, M. Witzenrath, A. D. Gruber, C. Drosten, L.-E. Sander, T. Wolff, S. Hippenstiel and A. C. Hocke (2022). "Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages." European Respiratory Journal. SYMPATH_ doi.org/10.1183/13993003.02725-2021.

Lingscheid, T., L. J. Lippert, D. Hillus, T. Kruis, C. Thibeault, E. T. Helbig, P. Tober-Lau, F. Pfäfflin, H. Müller-Redetzky, M. Witzenrath, T. Zoller, A. Uhrig, B. Opitz, N. Suttorp, T. S. Kramer, L. E. Sander, M. S. Stegemann and F. Kurth (2022). "Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study." Infection. CAPSyS & SYMPATH_ doi.org/10.1007/s15010-022-01796-w.

Pennitz, P., H. Kirsten, V. D. Friedrich, E. Wyler, C. Goekeri, B. Obermayer, G. A. Heinz, M.-F. Mashreghi, M. Büttner, J. Trimpert, M. Landthaler, N. Suttorp, A. C. Hocke, S. Hippenstiel, M. Tönnies, M. Scholz, W. M. Kuebler, M. Witzenrath, K. Hoenzke and G. Nouailles (2022). "A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics." European Respiratory Review 31(165). CAPSyS & SYMPATH_ doi.org/10.1183/16000617.0056-2022.

Rode, M., K. Nenoff, K. Wirkner, K. Horn, A. Teren, R. Regenthal, M. Loeffler, J. Thiery, A. Aigner, J. Pott, H. Kirsten and M. Scholz (2022). "Impact of medication on blood transcriptome reveals off-target regulations of beta-blockers." PLOS ONE 17(4): e0266897. SYMPATH_ doi.org/10.1371/journal.pone.0266897.

Scholz, M., K. Horn, J. Pott, A. Gross, M. E. Kleber, G. E. Delgado, P. P. Mishra, H. Kirsten, C. Gieger, M. Muller-Nurasyid, A. Tonjes, P. Kovacs, T. Lehtimaki, O. Raitakari, M. Kahonen, H. Gylling, R. Baber, B. Isermann, M. Stumvoll, M. Loeffler, W. Marz, T. Meitinger, A. Peters, J. Thiery, D. Teupser and U. Ceglarek (2022). "Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis." Nat Commun 13(1): 143. SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/35013273.

Wyler, E., J. M. Adler, K. Eschke, G. Teixeira Alves, S. Peidli, F. Pott, J. Kazmierski, L. Michalick, O. Kershaw, J. Bushe, S. Andreotti, P. Pennitz, A. Abdelgawad, D. Postmus, C. Goffinet, J. Kreye, S. M. Reincke, H. Prüss, N. Blüthgen, A. D. Gruber, W. M. Kuebler, M. Witzenrath, M. Landthaler, G. Nouailles and J. Trimpert (2022). "Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics." Mol Ther 30(5): 1952–1965. CAPSyS & SYMPATH_ doi.org/10.1016/j.ymthe.2022.03.014.

Catanese, S., C. F. Beuchel, T. Sawall, F. Lordick, R. Brauer, M. Scholz, U. Ceglarek and U. T. Hacker (2021). "Biomarkers related to fatty acid oxidative capacity are predictive for continued weight loss in cachectic cancer patients." J Cachexia Sarcopenia Muscle. SYMPATH_ doi.org/10.1002/jcsm.12817.

Demichev, V., P. Tober-Lau, O. Lemke, T. Nazarenko, C. Thibeault, H. Whitwell, A. Rohl, A. Freiwald, L. Szyrwiel, D. Ludwig, C. Correia-Melo, S. K. Aulakh, E. T. Helbig, P. Stubbemann, L. J. Lippert, N. M. Gruning, O. Blyuss, S. Vernardis, M. White, C. B. Messner, M. Joannidis, T. Sonnweber, S. J. Klein, A. Pizzini, Y. Wohlfarter, S. Sahanic, R. Hilbe, B. Schaefer, S. Wagner, M. Mittermaier, F. Machleidt, C. Garcia, C. Ruwwe-Glosenkamp, T. Lingscheid, L. Bosquillon de Jarcy, M. S. Stegemann, M. Pfeiffer, L. Jurgens, S. Denker, D. Zickler, P. Enghard, A. Zelezniak, A. Campbell, C. Hayward, D. J. Porteous, R. E. Marioni, A. Uhrig, H. Muller-Redetzky, H. Zoller, J. Loffler-Ragg, M. A. Keller, I. Tancevski, J. F. Timms, A. Zaikin, S. Hippenstiel, M. Ramharter, M. Witzenrath, N. Suttorp, K. Lilley, M. Mulleder, L. E. Sander, P.-C.-S. group, M. Ralser and F. Kurth (2021). "A time-resolved proteomic and prognostic map of COVID-19." Cell Syst 12(8): 780-794 e787. SYMPATH_ & CAPSyS www.ncbi.nlm.nih.gov/pubmed/34139154.

Hadzibegovic, S., A. Lena, T. W. Churchill, J. E. Ho, S. Potthoff, C. Denecke, L. Rösnick, K. M. Heim, M. Kleinschmidt, L. E. Sander, M. Witzenrath, N. Suttorp, A. Krannich, J. Porthun, T. Friede, J. Butler, U. Wilkenshoff, B. Pieske, U. Landmesser, S. D. Anker, G. D. Lewis, C. Tschöpe and M. S. Anker (2021). "Heart Failure with preserved ejection fraction according to the HFA‐PEFF score in COVID‐19 patients: clinical correlates and echocardiographic findings." European Journal of Heart Failure. CAPSyS & SYMPATH_ doi.org/10.1002/ejhf.2210.

Herta, T., A. Bhattacharyya, M. Rosolowski, C. Conrad, C. Gurtner, A. D. Gruber, P. Ahnert, B. Gutbier, D. Frey, N. Suttorp, S. Hippenstiel and J. Zahlten (2021). "Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia." Front Immunol 12: 726135. SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34589087.

Jagdmann, S., D. Berchtold, B. Gutbier, M. Witzenrath, A. Meisel, C. Meisel and C. Dames (2021). "Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections." Journal of Neuroimmunology 355: 577568. CAPSyS & SYMPATH_ doi.org/10.1016/j.jneuroim.2021.577568.

Letsiou, E., L. G. Teixeira Alves, D. Fatykhova, M. Felten, T. J. Mitchell, H. C. Müller-Redetzky, A. C. Hocke and M. Witzenrath (2021). "Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst - Scientific Reports." Sci Rep 11(9529): 1–13. CAPSyS & SYMPATH_ doi.org/10.1038/s41598-021-88897-y.

Letsiou, E., L. G. Teixeira Alves, M. Felten, T. J. Mitchell, H. C. Müller-Redetzky, S. M. Dudek and M. Witzenrath (2021). "Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure." Cells 10(12): 3581. CAPSyS & SYMPATH_ doi.org/10.3390/cells10123581.

Michalick, L., S. Weidenfeld, B. Grimmer, D. Fatykhova, P. D. Solymosi, F. Behrens, M. Dohmen, M. C. Brack, S. Schulz, E. Thomasch, S. Simmons, H. Müller-Redetzky, N. Suttorp, F. Kurth, J. Neudecker, M. Toennies, T. T. Bauer, S. Eggeling, V. M. Corman, A. C. Hocke, M. Witzenrath, S. Hippenstiel and W. M. Kuebler (2021). "Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure." European Respiratory Journal 57(3). CAPSyS & SYMPATH_ doi.org/10.1183/13993003.02384-2020.

Nouailles, G., E. Wyler, P. Pennitz, D. Postmus, D. Vladimirova, J. Kazmierski, F. Pott, K. Dietert, M. Muelleder, V. Farztdinov, B. Obermayer, S.-M. Wienhold, S. Andreotti, T. Hoefler, B. Sawitzki, C. Drosten, L. E. Sander, N. Suttorp, M. Ralser, D. Beule, A. D. Gruber, C. Goffinet, M. Landthaler, J. Trimpert and M. Witzenrath (2021). "Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19." Nat Commun 12. CAPSyS & SYMPATH_ doi.org/10.1038/s41467-021-25030-7.

Ochs, M., S. Timm, S. Elezkurtaj, D. Horst, J. Meinhardt, F. L. Heppner, S. Weber-Carstens, A. C. Hocke and M. Witzenrath (2021). "Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient." European Respiratory Journal 57(5). CAPSyS & SYMPATH_ doi.org/10.1183/13993003.04165-2020.

Pott, J., J. Gadin, E. Theusch, M. E. Kleber, G. E. Delgado, H. Kirsten, S. M. Hauck, R. Burkhardt, H. Scharnagl, R. M. Krauss, M. Loeffler, W. Marz, J. Thiery, A. Silveira, F. M. Vant Hooft and M. Scholz (2021). "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2." Hum Mol Genet. SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34590679.

Pott, J., K. Horn, R. Zeidler, H. Kirsten, P. Ahnert, J. Kratzsch, M. Loeffler, B. Isermann, U. Ceglarek and M. Scholz (2021). "Sex-Specific Causal Relations between Steroid Hormones and Obesity—A Mendelian Randomization Study." Metabolites 11(11): 738. SYMPATH_ doi.org/10.3390/metabo11110738.

Vosa, U., A. Claringbould, H. J. Westra, M. J. Bonder, P. Deelen, B. Zeng, H. Kirsten, A. Saha, R. Kreuzhuber, S. Yazar, H. Brugge, R. Oelen, D. H. de Vries, M. G. P. van der Wijst, S. Kasela, N. Pervjakova, I. Alves, M. J. Fave, M. Agbessi, M. W. Christiansen, R. Jansen, I. Seppala, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, R. Sonmez Flitman, A. Brown, V. Kukushkina, A. Kalnapenkis, S. Rueger, E. Porcu, J. Kronberg, J. Kettunen, B. Lee, F. Zhang, T. Qi, J. A. Hernandez, W. Arindrarto, F. Beutner, B. Consortium, Q. T. L. C. i, J. Dmitrieva, M. Elansary, B. P. Fairfax, M. Georges, B. T. Heijmans, A. W. Hewitt, M. Kahonen, Y. Kim, J. C. Knight, P. Kovacs, K. Krohn, S. Li, M. Loeffler, U. M. Marigorta, H. Mei, Y. Momozawa, M. Muller-Nurasyid, M. Nauck, M. G. Nivard, B. Penninx, J. K. Pritchard, O. T. Raitakari, O. Rotzschke, E. P. Slagboom, C. D. A. Stehouwer, M. Stumvoll, P. Sullivan, P. A. C. t Hoen, J. Thiery, A. Tonjes, J. van Dongen, M. van Iterson, J. H. Veldink, U. Volker, R. Warmerdam, C. Wijmenga, M. Swertz, A. Andiappan, G. W. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. van Meurs, H. Prokisch, H. Ahsan, B. L. Pierce, T. Lehtimaki, D. I. Boomsma, B. M. Psaty, S. A. Gharib, P. Awadalla, L. Milani, W. H. Ouwehand, K. Downes, O. Stegle, A. Battle, P. M. Visscher, J. Yang, M. Scholz, J. Powell, G. Gibson, T. Esko and L. Franke (2021). "Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression." Nat Genet 53(9): 1300-1310. SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34475573.

Weiner, J., P. Suwalski, M. Holtgrewe, A. Rakitko, C. Thibeault, M. Müller, D. Patriki, C. Quedenau, U. Krüger, V. Ilinsky, I. Popov, J. Balnis, A. Jaitovich, E. T. Helbig, L. J. Lippert, P. Stubbemann, L. M. Real, J. Macías, J. A. Pineda, M. Fernandez-Fuertes, X. Wang, Z. Karadeniz, J. Saccomanno, J.-M. Doehn, R.-H. Hübner, B. Hinzmann, M. Salvo, A. Blueher, S. Siemann, S. Jurisic, J. H. Beer, J. Rutishauser, B. Wiggli, H. Schmid, K. Danninger, R. Binder, V. M. Corman, B. Mühlemann, R. Arjun Arkal, G. K. Fragiadakis, E. Mick, C. COMET, C. S. Calfee, D. J. Erle, C. M. Hendrickson, K. N. Kangelaris, M. F. Krummel, P. G. Woodruff, C. R. Langelier, U. Venkataramani, F. García, J. Zyla, C. Drosten, B. Alice, T. C. Jones, N. Suttorp, M. Witzenrath, S. Hippenstiel, T. Zemojtel, C. Skurk, W. Poller, T. Borodina, S. G. Pa-COVID, S. Ripke, L. E. Sander, D. Beule, U. Landmesser, T. Guettouche, F. Kurth and B. Heidecker (2021). "Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01." EClinicalMedicine 40: 101099. CAPSyS & SYMPATH_ doi.org/10.1016/j.eclinm.2021.101099.

Wienhold, S. M., M. C. Brack, G. Nouailles, G. Krishnamoorthy, I. H. E. Korf, C. Seitz, S. Wienecke, K. Dietert, C. Gurtner, O. Kershaw, A. D. Gruber, A. Ross, H. Ziehr, M. Rohde, J. Neudecker, J. Lienau, N. Suttorp, S. Hippenstiel, A. C. Hocke, C. Rohde and M. Witzenrath (2021). "Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection." Viruses 14(1). CAPSyS & SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/35062236.

Witzenrath, M. and W. M. Kuebler (2021). "The CypA-netics of Ventilator-induced Lung Injury." Am J Respir Crit Care Med 204(4): 385-387. CAPSyS & SYMPATH_ www.ncbi.nlm.nih.gov/pubmed/34033522.

Kreye, J., Reincke, S.M., Kornau, H.-C., Sánchez-Sendin, E., Corman, V.M., Liu, H., Yuan, M., Wu, N.C., Zhu, X., Lee, C.-C.D., Trimpert, J., Höltje, M., Dietert, K., Stöffler, L., von Wardenburg, N., van Hoof, S., Homeyer, M.A., Hoffmann, J., Abdelgawad, A., Gruber, A.D., Bertzbach, L.D., Vladimirova, D., Li, L.Y., Barthel, P.C., Skriner, K., Hocke, A.C., Hippenstiel, S., Witzenrath, M., Suttorp, N., Kurth, F., Franke, C., Endres, M., Schmitz, D., Jeworowski, L.M., Richter, A., Schmidt, M.L., Schwarz, T., Müller, M.A., Drosten, C., Wendisch, D., Sander, L.E., Osterrieder, N., Wilson, I.A. and Prüss, H. (2020). "A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model." Cell 183(4): 1058–1069.e1019. doi.org/10.1016/j.cell.2020.09.049.

Messner, C.B., Demichev, V., Wendisch, D., Michalick, L., White, M., Freiwald, A., Textoris-Taube, K., Vernardis, S., Egger, A.-S., Kreidl, M., Ludwig, D., Kilian, C., Agostini, F., Zelezniak, A., Thibeault, C., Pfeiffer, M., Hippenstiel, S., Hocke, A., von Kalle, C., Campbell, A., Hayward, C., Porteous, D.J., Marioni, R.E., Langenberg, C. and Lilley, K.S. (2020). "Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection." Cell Systems 11(1): 11–+. doi.org/10.1016/j.cels.2020.05.012.

Mittermaier, M., Pickerodt, P., Kurth, F., de Jarcy, L.B., Uhrig, A., Garcia, C., Machleidt, F., Pergantis, P., Weber, S., Li, Y., Breitbart, A., Bremer, F., Knape, P., Dewey, M., Doellinger, F., Weber-Carstens, S., Slutsky, A.S., Kuebler, W.M., Suttorp, N. and Müller-Redetzky, H. (2020). "Evaluation of PEEP and prone positioning in early COVID-19 ARDS." EClinicalMedicine 28: 100579. doi.org/10.1016/j.eclinm.2020.100579.

Schirm, S., Ahnert, P., Berger, S., Nouailles, G., Wienhold, S.-M., Müller-Redetzky, H., Suttorp, N., Loeffler, M., Witzenrath, M. and Scholz, M. (2020). "A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection." PLOS ONE 15(12): e0243147. doi.org/10.1371/journal.pone.0243147.